TEP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.67542680
2modulation by symbiont of host defense response (GO:0052031)4.77219747
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.77219747
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.77219747
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.77219747
6modulation by symbiont of host immune response (GO:0052553)4.77219747
7positive regulation by symbiont of host defense response (GO:0052509)4.77219747
8neutrophil activation involved in immune response (GO:0002283)4.61998503
9regulation of interferon-beta biosynthetic process (GO:0045357)4.56440359
10positive regulation of gamma-delta T cell activation (GO:0046645)4.27976740
11antigen processing and presentation of endogenous antigen (GO:0019883)4.17840048
12immunoglobulin mediated immune response (GO:0016064)4.12153654
13positive regulation of interferon-alpha production (GO:0032727)4.10790686
14detection of other organism (GO:0098543)4.02504096
15positive regulation of antigen processing and presentation (GO:0002579)3.96121245
16regulation of interferon-alpha production (GO:0032647)3.86811345
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.86362052
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.86362052
19macrophage activation involved in immune response (GO:0002281)3.84365226
20detection of bacterium (GO:0016045)3.83765148
21response to peptidoglycan (GO:0032494)3.63035704
22regulation of B cell receptor signaling pathway (GO:0050855)3.55507533
23detection of external biotic stimulus (GO:0098581)3.54977937
24neutrophil activation (GO:0042119)3.51478924
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.50481639
26positive regulation of B cell differentiation (GO:0045579)3.49370590
27natural killer cell mediated cytotoxicity (GO:0042267)3.49358533
28natural killer cell mediated immunity (GO:0002228)3.49358533
29granulocyte activation (GO:0036230)3.43690278
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.42484883
31negative thymic T cell selection (GO:0045060)3.41047053
32response to muramyl dipeptide (GO:0032495)3.40332676
33respiratory burst (GO:0045730)3.38387116
34negative regulation of erythrocyte differentiation (GO:0045647)3.35097075
35production of molecular mediator involved in inflammatory response (GO:0002532)3.28955051
36regulation of cholesterol storage (GO:0010885)3.28691773
37regulation of antigen processing and presentation (GO:0002577)3.27682711
38negative T cell selection (GO:0043383)3.26541553
39pinocytosis (GO:0006907)3.24970055
40regulation of B cell differentiation (GO:0045577)3.18574508
41myeloid cell activation involved in immune response (GO:0002275)3.18408041
42negative regulation of granulocyte differentiation (GO:0030853)3.17832618
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.14391825
44response to type I interferon (GO:0034340)3.12667315
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.11397763
46regulation of gamma-delta T cell activation (GO:0046643)3.10295476
47detection of biotic stimulus (GO:0009595)3.09260386
48cellular response to type I interferon (GO:0071357)3.07965101
49type I interferon signaling pathway (GO:0060337)3.07965101
50negative regulation of T cell mediated immunity (GO:0002710)3.06925590
51leukocyte aggregation (GO:0070486)3.06386107
52cellular extravasation (GO:0045123)3.04456315
53defense response to protozoan (GO:0042832)3.04299431
54regulation of gamma-delta T cell differentiation (GO:0045586)3.03502899
55interferon-gamma-mediated signaling pathway (GO:0060333)3.03394595
56B cell mediated immunity (GO:0019724)3.02858174
57positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.01784525
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00381445
59positive regulation of interferon-beta production (GO:0032728)2.99518182
60response to host immune response (GO:0052572)2.99446882
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99446882
62myeloid dendritic cell activation (GO:0001773)2.99268210
63T cell selection (GO:0045058)2.99038942
64response to interleukin-15 (GO:0070672)2.92110735
65neutrophil mediated immunity (GO:0002446)2.91711793
66thymic T cell selection (GO:0045061)2.90954621
67regulation of T cell tolerance induction (GO:0002664)2.88672401
68negative regulation of leukocyte mediated immunity (GO:0002704)2.87094764
69lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87023872
70negative regulation of lipid storage (GO:0010888)2.86673810
71positive regulation of natural killer cell differentiation (GO:0032825)2.84582039
72antigen processing and presentation via MHC class Ib (GO:0002475)2.84181306
73positive T cell selection (GO:0043368)2.83830083
74lipoprotein transport (GO:0042953)2.82904162
75regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82874150
76positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82386909
77regulation of tolerance induction (GO:0002643)2.82156715
78B cell receptor signaling pathway (GO:0050853)2.79513875
79cellular response to ethanol (GO:0071361)2.79053718
80T cell migration (GO:0072678)2.78140220
81negative regulation of interleukin-12 production (GO:0032695)2.78136904
82negative regulation of cell killing (GO:0031342)2.77748106
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77748106
84myeloid dendritic cell differentiation (GO:0043011)2.74698323
85regulation of leukocyte degranulation (GO:0043300)2.74320498
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72459018
87response to host (GO:0075136)2.72459018
88response to host defenses (GO:0052200)2.72459018
89regulation of mast cell degranulation (GO:0043304)2.71130843
90regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.70096785
91NIK/NF-kappaB signaling (GO:0038061)2.69016034
92response to protozoan (GO:0001562)2.68191288
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67972577
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67840119
95positive regulation of cellular amide metabolic process (GO:0034250)2.67548997
96regulation of necroptotic process (GO:0060544)2.67493584
97apoptotic cell clearance (GO:0043277)2.66939234
98regulation of integrin activation (GO:0033623)2.65833448
99low-density lipoprotein particle clearance (GO:0034383)2.65046980
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.64580663
101histone H3-K36 demethylation (GO:0070544)2.63903373
102positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.62699644
103leukocyte mediated cytotoxicity (GO:0001909)2.62377171
104positive regulation of Cdc42 GTPase activity (GO:0043089)2.62084275
105germinal center formation (GO:0002467)2.60975593
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60652514
107positive thymic T cell selection (GO:0045059)2.59616110
108dendritic cell migration (GO:0036336)2.59424126
109hydrogen peroxide biosynthetic process (GO:0050665)2.58613712
110T-helper 1 type immune response (GO:0042088)2.57946602
111cytokine secretion (GO:0050663)2.57239589
112dendritic cell differentiation (GO:0097028)2.57096459
113detection of molecule of bacterial origin (GO:0032490)2.55901351
114phospholipid homeostasis (GO:0055091)2.55267589
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54944256
116positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.54664089
117mature B cell differentiation (GO:0002335)2.53518104
118negative regulation of innate immune response (GO:0045824)2.53081477
119myeloid leukocyte activation (GO:0002274)2.52653835
120macrophage activation (GO:0042116)2.52527043
121regulation of mast cell activation (GO:0033003)2.52309702
122regulation of mast cell activation involved in immune response (GO:0033006)2.52153177
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49889514
124regulation of T-helper 2 cell differentiation (GO:0045628)2.49842211
125leukocyte cell-cell adhesion (GO:0007159)2.49522334
126microglial cell activation (GO:0001774)2.49486319
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49418009
128positive regulation of tolerance induction (GO:0002645)2.49082596
129dendritic cell chemotaxis (GO:0002407)2.48782530
130mannose metabolic process (GO:0006013)2.47731326
131interferon-gamma secretion (GO:0072643)2.47235473
132I-kappaB phosphorylation (GO:0007252)2.47095790
133positive regulation of mast cell activation (GO:0033005)2.46802145
134tolerance induction (GO:0002507)2.46552062
135leukotriene metabolic process (GO:0006691)2.46360714
136cytidine catabolic process (GO:0006216)2.45603157
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.44465685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.86904203
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.93615866
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.21879783
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.74219264
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.66906875
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22608301
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16448589
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14383192
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.13485548
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10726192
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.08904844
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97838696
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84159402
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43429150
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.41603004
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41355302
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.36966885
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30232066
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.27382040
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.26788825
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07750221
22SCL_19346495_ChIP-Seq_HPC-7_Human2.06784142
23* SPI1_23547873_ChIP-Seq_NB4_Human2.03427280
24SPI1_23127762_ChIP-Seq_K562_Human2.02640703
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01467599
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.97342189
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94361476
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91953671
29VDR_21846776_ChIP-Seq_THP-1_Human1.90583980
30VDR_24763502_ChIP-Seq_THP-1_Human1.90230716
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87143784
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.81157481
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78947355
34E2F7_22180533_ChIP-Seq_HELA_Human1.76220213
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.75940050
36GATA1_22025678_ChIP-Seq_K562_Human1.74972103
37MYB_26560356_Chip-Seq_TH2_Human1.73452892
38RUNX_20019798_ChIP-Seq_JUKART_Human1.71210928
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70171227
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68079681
41MAF_26560356_Chip-Seq_TH1_Human1.66459509
42MYB_26560356_Chip-Seq_TH1_Human1.65931293
43PU_27001747_Chip-Seq_BMDM_Mouse1.65315450
44KDM2B_26808549_Chip-Seq_DND41_Human1.57753099
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51012724
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50391273
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47642841
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47497742
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46235442
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45783543
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.45645421
52VDR_24787735_ChIP-Seq_THP-1_Human1.43045346
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42951094
54PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40193382
55TCF7_22412390_ChIP-Seq_EML_Mouse1.40140687
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38112007
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37796595
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35309990
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.35109283
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.33628942
61GATA1_19941826_ChIP-Seq_K562_Human1.32865653
62LXR_22292898_ChIP-Seq_THP-1_Human1.28058768
63MYC_22102868_ChIP-Seq_BL_Human1.26769978
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26768391
65UTX_26944678_Chip-Seq_JUKART_Human1.22440819
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21096590
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20419144
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18549170
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17872432
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16852028
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16699321
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15814795
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14645297
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12777482
75GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12033406
76GATA3_27048872_Chip-Seq_THYMUS_Human1.11811224
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.11183102
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09875675
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.08585571
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08352341
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.07515561
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03717667
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.03452413
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03264976
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03218063
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02978084
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01845255
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01402765
89CDX2_20551321_ChIP-Seq_CACO-2_Human1.00659807
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.00524251
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99800118
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.99777976
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99727481
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99715496
95GATA3_26560356_Chip-Seq_TH2_Human0.98552772
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98387903
97GATA2_19941826_ChIP-Seq_K562_Human0.98377082
98RACK7_27058665_Chip-Seq_MCF-7_Human0.98098875
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97765645
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96897637
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96897637
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96481111
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96411998
104GATA6_25053715_ChIP-Seq_YYC3_Human0.95986049
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95772632
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93996079
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93453490
108TFEB_21752829_ChIP-Seq_HELA_Human0.92889022
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91160087
110MAF_26560356_Chip-Seq_TH2_Human0.90498398
111* GATA4_25053715_ChIP-Seq_YYC3_Human0.90199546
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89713237
113RUNX1_27514584_Chip-Seq_MCF-7_Human0.89670699
114FOXM1_23109430_ChIP-Seq_U2OS_Human0.88171515
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87947004
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86575924
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86449307
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86335900
119KDM2B_26808549_Chip-Seq_K562_Human0.83223479
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81845768
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81562386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.94097426
2MP0000569_abnormal_digit_pigmentation3.65162522
3MP0003436_decreased_susceptibility_to3.21818180
4MP0005058_abnormal_lysosome_morphology2.78796412
5MP0002419_abnormal_innate_immunity2.60335718
6MP0000685_abnormal_immune_system2.50586633
7MP0009785_altered_susceptibility_to2.47491944
8MP0002148_abnormal_hypersensitivity_rea2.41827264
9MP0005387_immune_system_phenotype2.41806687
10MP0001790_abnormal_immune_system2.41806687
11MP0005025_abnormal_response_to2.37880365
12MP0005000_abnormal_immune_tolerance2.37202772
13MP0001800_abnormal_humoral_immune2.33391253
14MP0002452_abnormal_antigen_presenting2.33197032
15MP0005671_abnormal_response_to2.16769720
16MP0003303_peritoneal_inflammation2.13307394
17MP0003191_abnormal_cellular_cholesterol2.12811563
18MP0006082_CNS_inflammation2.12736369
19MP0003300_gastrointestinal_ulcer2.11983232
20MP0005464_abnormal_platelet_physiology2.11917697
21MP0005451_abnormal_body_composition2.11615265
22MP0002166_altered_tumor_susceptibility2.11193144
23MP0002723_abnormal_immune_serum2.07417610
24MP0003172_abnormal_lysosome_physiology2.03847029
25MP0001819_abnormal_immune_cell1.94300011
26MP0002420_abnormal_adaptive_immunity1.91973448
27MP0009840_abnormal_foam_cell1.91426173
28MP0004510_myositis1.91289705
29MP0008260_abnormal_autophagy1.87587662
30MP0002006_tumorigenesis1.85945656
31MP0005174_abnormal_tail_pigmentation1.83668493
32MP0010155_abnormal_intestine_physiology1.79404891
33MP0003183_abnormal_peptide_metabolism1.77525007
34MP0004947_skin_inflammation1.76679407
35MP0001533_abnormal_skeleton_physiology1.65534010
36MP0009278_abnormal_bone_marrow1.64821295
37MP0001873_stomach_inflammation1.64172646
38MP0003724_increased_susceptibility_to1.62790626
39MP0002405_respiratory_system_inflammati1.62078838
40MP0001845_abnormal_inflammatory_respons1.61002663
41MP0005360_urolithiasis1.54936340
42MP0001853_heart_inflammation1.50556727
43MP0010352_gastrointestinal_tract_polyps1.49712306
44MP0003705_abnormal_hypodermis_morpholog1.49708721
45MP0000716_abnormal_immune_system1.44536899
46MP0002398_abnormal_bone_marrow1.41394707
47MP0010307_abnormal_tumor_latency1.40597803
48MP0008469_abnormal_protein_level1.40049790
49MP0001545_abnormal_hematopoietic_system1.37741056
50MP0005397_hematopoietic_system_phenotyp1.37741056
51MP0003566_abnormal_cell_adhesion1.34729291
52MP0002396_abnormal_hematopoietic_system1.33477175
53MP0004883_abnormal_blood_vessel1.33166852
54MP0003448_altered_tumor_morphology1.30420674
55MP0005310_abnormal_salivary_gland1.29495424
56MP0000689_abnormal_spleen_morphology1.26227782
57MP0003866_abnormal_defecation1.23248684
58MP0009333_abnormal_splenocyte_physiolog1.21643600
59MP0008438_abnormal_cutaneous_collagen1.20864379
60MP0000858_altered_metastatic_potential1.20521583
61MP0002429_abnormal_blood_cell1.19083073
62MP0005076_abnormal_cell_differentiation1.18123893
63MP0000371_diluted_coat_color1.17371825
64MP0002998_abnormal_bone_remodeling1.16354046
65MP0002722_abnormal_immune_system1.15670624
66MP0005164_abnormal_response_to1.15459114
67MP0009764_decreased_sensitivity_to1.14167330
68MP0004381_abnormal_hair_follicle1.13162469
69MP0000015_abnormal_ear_pigmentation1.12782537
70MP0005257_abnormal_intraocular_pressure1.11723683
71MP0000465_gastrointestinal_hemorrhage1.08434168
72MP0002009_preneoplasia1.06767951
73MP0000490_abnormal_crypts_of1.05415022
74MP0000703_abnormal_thymus_morphology1.04065288
75MP0002254_reproductive_system_inflammat1.04039554
76MP0003763_abnormal_thymus_physiology0.99562192
77MP0003690_abnormal_glial_cell0.96892246
78MP0002933_joint_inflammation0.95754346
79MP0006054_spinal_hemorrhage0.94291153
80MP0009763_increased_sensitivity_to0.93317127
81MP0005409_darkened_coat_color0.92618888
82MP0002138_abnormal_hepatobiliary_system0.92013518
83MP0004264_abnormal_extraembryonic_tissu0.91504091
84MP0008004_abnormal_stomach_pH0.91269743
85MP0000609_abnormal_liver_physiology0.88536462
86MP0000343_altered_response_to0.88334163
87MP0010329_abnormal_lipoprotein_level0.87256860
88MP0002139_abnormal_hepatobiliary_system0.87227913
89MP0003279_aneurysm0.87210612
90MP0001666_abnormal_nutrient_absorption0.87059875
91MP0003453_abnormal_keratinocyte_physiol0.86933311
92MP0003828_pulmonary_edema0.85947189
93MP0004808_abnormal_hematopoietic_stem0.85896934
94MP0005166_decreased_susceptibility_to0.85672228
95MP0005670_abnormal_white_adipose0.84402976
96MP0001958_emphysema0.82639375
97MP0002060_abnormal_skin_morphology0.81414365
98MP0003656_abnormal_erythrocyte_physiolo0.80385911
99MP0002132_abnormal_respiratory_system0.78619423
100MP0005390_skeleton_phenotype0.76714979
101MP0002136_abnormal_kidney_physiology0.76422217
102MP0005023_abnormal_wound_healing0.76149538
103MP0003075_altered_response_to0.75629617
104MP0003045_fibrosis0.75541864
105MP0001663_abnormal_digestive_system0.75261072
106MP0003252_abnormal_bile_duct0.74050850
107MP0005365_abnormal_bile_salt0.73627172
108MP0002877_abnormal_melanocyte_morpholog0.73067461
109MP0003091_abnormal_cell_migration0.72823215
110MP0000604_amyloidosis0.71841762
111MP0004185_abnormal_adipocyte_glucose0.71780831
112MP0004782_abnormal_surfactant_physiolog0.71462690
113MP0001851_eye_inflammation0.70607050
114MP0010234_abnormal_vibrissa_follicle0.70277892
115MP0009115_abnormal_fat_cell0.69300953
116MP0000249_abnormal_blood_vessel0.68984590
117MP0003795_abnormal_bone_structure0.68620126

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.21189213
2Recurrent bacterial skin infections (HP:0005406)5.91021761
3Eczematoid dermatitis (HP:0000976)5.42321501
4Recurrent gram-negative bacterial infections (HP:0005420)4.82372231
5Autoimmune thrombocytopenia (HP:0001973)4.11355380
6Vacuolated lymphocytes (HP:0001922)3.96396697
7Elevated erythrocyte sedimentation rate (HP:0003565)3.93644454
8Myositis (HP:0100614)3.84991781
9Gingivitis (HP:0000230)3.82655882
10Abnormality of macrophages (HP:0004311)3.73845248
11Periodontitis (HP:0000704)3.72939051
12Recurrent fungal infections (HP:0002841)3.72383036
13Recurrent skin infections (HP:0001581)3.66032259
14Systemic lupus erythematosus (HP:0002725)3.63007818
15Orchitis (HP:0100796)3.45423281
16Pustule (HP:0200039)3.44294323
17Increased cerebral lipofuscin (HP:0011813)3.39484835
18Recurrent viral infections (HP:0004429)3.23607125
19Retrobulbar optic neuritis (HP:0100654)3.22138431
20Optic neuritis (HP:0100653)3.22138431
21Mediastinal lymphadenopathy (HP:0100721)3.18579977
22Myocardial infarction (HP:0001658)3.02757437
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.91376050
24T lymphocytopenia (HP:0005403)2.90465593
25Abnormality of T cell number (HP:0011839)2.78751184
26Dysostosis multiplex (HP:0000943)2.78053150
27Cellulitis (HP:0100658)2.77570191
28Colitis (HP:0002583)2.76653918
29Malnutrition (HP:0004395)2.75976381
30Vasculitis (HP:0002633)2.75302412
31Disinhibition (HP:0000734)2.73748925
32Abnormality of glycolipid metabolism (HP:0010969)2.73699293
33Abnormality of liposaccharide metabolism (HP:0010968)2.73699293
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.73699293
35Hematochezia (HP:0002573)2.72895964
36Encephalitis (HP:0002383)2.69185059
37Chronic mucocutaneous candidiasis (HP:0002728)2.68061272
38Recurrent cutaneous fungal infections (HP:0011370)2.68061272
39Osteomyelitis (HP:0002754)2.65799822
40Inflammation of the large intestine (HP:0002037)2.61768983
41Axonal loss (HP:0003447)2.58541059
42Prostate neoplasm (HP:0100787)2.56953184
43Gingival bleeding (HP:0000225)2.56631029
44Arterial thrombosis (HP:0004420)2.52943736
45Osteolytic defects of the hand bones (HP:0009699)2.52386145
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.52386145
47Thick nail (HP:0001805)2.52023764
48Chest pain (HP:0100749)2.51735194
49Urinary glycosaminoglycan excretion (HP:0003541)2.51525799
50Mucopolysacchariduria (HP:0008155)2.51525799
51Interstitial pulmonary disease (HP:0006530)2.50349142
52Abnormality of polysaccharide metabolism (HP:0011012)2.46811779
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46811779
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46811779
55Gastrointestinal inflammation (HP:0004386)2.43354587
56Agammaglobulinemia (HP:0004432)2.41766213
57Obstructive lung disease (HP:0006536)2.41646125
58Chronic obstructive pulmonary disease (HP:0006510)2.41646125
59Premature loss of primary teeth (HP:0006323)2.41438441
60Glomerulonephritis (HP:0000099)2.37517348
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36419248
62Panhypogammaglobulinemia (HP:0003139)2.31415585
63Leukocytosis (HP:0001974)2.29168822
64Meningitis (HP:0001287)2.27504044
65Viral hepatitis (HP:0006562)2.24939752
66Pulmonary infiltrates (HP:0002113)2.22685724
67Gastrointestinal stroma tumor (HP:0100723)2.22495969
68Abnormality of T cells (HP:0002843)2.22195161
69Basal ganglia calcification (HP:0002135)2.18622858
70Thin bony cortex (HP:0002753)2.13042390
71Urticaria (HP:0001025)2.12765848
72Chronic diarrhea (HP:0002028)2.12635412
73Keratoconjunctivitis sicca (HP:0001097)2.11912799
74Loss of speech (HP:0002371)2.11181220
75Stomatitis (HP:0010280)2.10444128
76Pulmonary embolism (HP:0002204)2.10261628
77Nephritis (HP:0000123)2.08732538
78Chronic otitis media (HP:0000389)2.07492058
79IgM deficiency (HP:0002850)2.07022288
80Recurrent pneumonia (HP:0006532)2.06751726
81Abnormality of the fingertips (HP:0001211)2.06515414
82Increased IgE level (HP:0003212)2.05184509
83Recurrent bronchitis (HP:0002837)2.05163972
84Spontaneous hematomas (HP:0007420)2.05100450
85Gastrointestinal infarctions (HP:0005244)2.04880817
86Peritonitis (HP:0002586)2.04003619
87Abnormality of complement system (HP:0005339)2.03988940
88Cheilitis (HP:0100825)2.03526898
89Abnormality of the peritoneum (HP:0002585)2.01227640
90Pathologic fracture (HP:0002756)2.00375354
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99379437
92Keratoconjunctivitis (HP:0001096)1.98786545
93Lymphopenia (HP:0001888)1.98619826
94Agnosia (HP:0010524)1.98574001
95Hemorrhage of the eye (HP:0011885)1.97170795
96Petechiae (HP:0000967)1.97010238
97Epistaxis (HP:0000421)1.96770858
98Autoimmune hemolytic anemia (HP:0001890)1.96248294
99Restrictive lung disease (HP:0002091)1.95972836
100Emphysema (HP:0002097)1.95599790
101Granulocytopenia (HP:0001913)1.95374329
102Thoracic kyphosis (HP:0002942)1.95117542
103Amyloidosis (HP:0011034)1.95039030
104Hemoptysis (HP:0002105)1.93939988
105Spondylolisthesis (HP:0003302)1.93697185
106Subacute progressive viral hepatitis (HP:0006572)1.93451210
107Prolonged bleeding time (HP:0003010)1.93385568
108Eosinophilia (HP:0001880)1.93268127
109Bone pain (HP:0002653)1.92338654
110Abnormality of cells of the lymphoid lineage (HP:0012140)1.90623983
111Thrombocytosis (HP:0001894)1.89895655
112Cerebral aneurysm (HP:0004944)1.89733251
113Joint hemorrhage (HP:0005261)1.88351807
114Abnormality of T cell physiology (HP:0011840)1.87720236
115Abnormal platelet function (HP:0011869)1.87600735
116Impaired platelet aggregation (HP:0003540)1.87600735
117Thyroiditis (HP:0100646)1.85992409
118Recurrent lower respiratory tract infections (HP:0002783)1.83995677
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83029444
120Abnormality of the thoracic spine (HP:0100711)1.82793201
121Abnormality of the pleura (HP:0002103)1.82613837
122Skin ulcer (HP:0200042)1.82057849
123Segmental peripheral demyelination/remyelination (HP:0003481)1.81942603
124Abnormal platelet volume (HP:0011876)1.80807981
125Hypergammaglobulinemia (HP:0010702)1.78251932
126Verrucae (HP:0200043)1.77683338
127Papilloma (HP:0012740)1.77683338
128Abnormality of the endocardium (HP:0004306)1.77349578
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.76939861
130Frequent falls (HP:0002359)1.74883916
131Complement deficiency (HP:0004431)1.73812500
132Hypercholesterolemia (HP:0003124)1.73624564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.54040933
2MAP3K143.06941082
3TYK23.05363757
4IRAK32.72275900
5RIPK42.69876157
6IRAK42.69664682
7TBK12.68235971
8KIT2.65326176
9PRPF4B2.64130728
10TAOK32.62637545
11ERN12.40054963
12BLK2.37609084
13JAK32.11924029
14IKBKE1.96262018
15JAK11.93433295
16IKBKB1.84566581
17NEK91.81693754
18CAMK1D1.78441764
19TTN1.74191385
20TGFBR21.73441809
21CSF1R1.68064235
22ZAP701.61476425
23FRK1.53348236
24RIPK11.46009253
25CDC42BPA1.44864755
26CSK1.44557908
27MAP2K31.41663911
28STK101.38359633
29CDK121.37883131
30BTK1.36780339
31CHUK1.34423561
32TXK1.33700837
33EPHB11.32346440
34SYK1.31467859
35HCK1.29583402
36CAMK1G1.25364946
37FGFR41.23848572
38TEC1.23619318
39TRIB31.22750990
40TNK21.22265850
41PTK61.20841618
42NME21.19625920
43MAP3K101.18037846
44FGFR31.16717600
45PIM11.15730796
46MAP3K131.14025122
47FLT31.13877357
48MAP3K11.08122574
49MAP3K71.07571627
50TRPM71.06865696
51MARK21.06381358
52PIM21.05450367
53LCK1.04971985
54TAOK11.03941685
55CDK61.03858987
56RPS6KA41.03292066
57ITK1.00385174
58MST1R1.00099727
59MAP3K30.99494903
60JAK20.98769552
61SMG10.98493835
62PKN20.95413893
63LYN0.92810831
64IRAK10.90624266
65BMPR20.88904600
66GRK60.87279568
67PDPK10.85915984
68PRKD20.85558350
69MST40.84873430
70MARK30.83867271
71FES0.81107575
72KSR20.80513824
73STK40.79834495
74SIK10.79554970
75MAPK70.79306699
76MAP3K20.78033355
77ICK0.78005841
78LRRK20.77796654
79PIK3CG0.76712739
80MATK0.76560471
81CLK10.72584665
82NUAK10.71501044
83HIPK20.70596594
84MAP3K60.70434035
85MAP3K110.68921526
86MAPK120.68107658
87RET0.67589160
88SGK30.66697320
89ACVR1B0.65619598
90SIK30.59973736
91PAK40.58601160
92STK30.57598826
93CDK90.56878490
94ABL10.55464477
95MELK0.55181238
96MAP2K60.54426972
97EPHA30.53291029
98BMX0.53161020
99MAPK110.53129260
100DMPK0.52277964
101EEF2K0.51464974
102PRKG20.50840534
103EGFR0.50823872
104CDK40.50639082
105WNK10.50189778
106SIK20.49613129
107SCYL20.48514977
108SGK20.48173665
109FYN0.47077232
110IRAK20.44938494
111YES10.44327024
112CAMKK10.44057045
113RPS6KA60.43164198
114MAPKAPK20.41576752
115PDGFRB0.41320039
116PRKCD0.39846201
117PRKAA20.37424618
118FGR0.36850002
119STK240.36708044
120NLK0.35495132
121PRKCQ0.34841376
122NEK20.34006639
123RPS6KL10.33920878
124RPS6KC10.33920878
125DYRK1B0.33101599
126MTOR0.32294909
127BRD40.31123183
128PTK20.30192540
129MAP3K80.29742132
130PDK10.29284292
131RPS6KA20.28101465

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.00093145
2Staphylococcus aureus infection_Homo sapiens_hsa051502.88174975
3Caffeine metabolism_Homo sapiens_hsa002322.50288952
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.43500638
5Osteoclast differentiation_Homo sapiens_hsa043802.39570530
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37029367
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28937068
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09022786
9Pertussis_Homo sapiens_hsa051332.06448272
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.05030422
11Tuberculosis_Homo sapiens_hsa051521.99805334
12B cell receptor signaling pathway_Homo sapiens_hsa046621.98110074
13Lysosome_Homo sapiens_hsa041421.97224592
14Other glycan degradation_Homo sapiens_hsa005111.96187695
15Legionellosis_Homo sapiens_hsa051341.93227519
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.91671764
17Measles_Homo sapiens_hsa051621.89357953
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78881021
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74514133
20Influenza A_Homo sapiens_hsa051641.67380176
21Toxoplasmosis_Homo sapiens_hsa051451.64401356
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63975353
23Malaria_Homo sapiens_hsa051441.63065812
24Graft-versus-host disease_Homo sapiens_hsa053321.56822738
25Primary immunodeficiency_Homo sapiens_hsa053401.49342072
26Antigen processing and presentation_Homo sapiens_hsa046121.47987815
27Hematopoietic cell lineage_Homo sapiens_hsa046401.47692989
28TNF signaling pathway_Homo sapiens_hsa046681.36708996
29Apoptosis_Homo sapiens_hsa042101.36136738
30Salmonella infection_Homo sapiens_hsa051321.31987531
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31161831
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.29393086
33Herpes simplex infection_Homo sapiens_hsa051681.28784295
34Allograft rejection_Homo sapiens_hsa053301.28593064
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27063238
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23756117
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.23355074
38Renin-angiotensin system_Homo sapiens_hsa046141.21991362
39Phagosome_Homo sapiens_hsa041451.19926911
40Rheumatoid arthritis_Homo sapiens_hsa053231.15038095
41Viral myocarditis_Homo sapiens_hsa054161.11842396
42Non-small cell lung cancer_Homo sapiens_hsa052231.11013724
43Complement and coagulation cascades_Homo sapiens_hsa046101.10569854
44Chemokine signaling pathway_Homo sapiens_hsa040621.08892958
45Shigellosis_Homo sapiens_hsa051311.07730768
46Hepatitis C_Homo sapiens_hsa051601.04046453
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99560955
48Acute myeloid leukemia_Homo sapiens_hsa052210.98230484
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97789003
50Hepatitis B_Homo sapiens_hsa051610.97572895
51ABC transporters_Homo sapiens_hsa020100.94679620
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93527102
53VEGF signaling pathway_Homo sapiens_hsa043700.93038529
54Chronic myeloid leukemia_Homo sapiens_hsa052200.92801338
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92695720
56Fat digestion and absorption_Homo sapiens_hsa049750.88344545
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88330372
58African trypanosomiasis_Homo sapiens_hsa051430.86015741
59Renal cell carcinoma_Homo sapiens_hsa052110.84644182
60Amoebiasis_Homo sapiens_hsa051460.84086096
61PPAR signaling pathway_Homo sapiens_hsa033200.83468049
62Pancreatic cancer_Homo sapiens_hsa052120.82482544
63Dorso-ventral axis formation_Homo sapiens_hsa043200.82377193
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81895478
65Platelet activation_Homo sapiens_hsa046110.81408492
66Starch and sucrose metabolism_Homo sapiens_hsa005000.80067022
67Insulin resistance_Homo sapiens_hsa049310.79154037
68Notch signaling pathway_Homo sapiens_hsa043300.78659433
69T cell receptor signaling pathway_Homo sapiens_hsa046600.77974191
70GnRH signaling pathway_Homo sapiens_hsa049120.75917446
71Lysine degradation_Homo sapiens_hsa003100.74882243
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74656150
73Mineral absorption_Homo sapiens_hsa049780.74088847
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.72825604
75Small cell lung cancer_Homo sapiens_hsa052220.72689891
76Asthma_Homo sapiens_hsa053100.71680478
77Galactose metabolism_Homo sapiens_hsa000520.71401511
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71374757
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.69094505
80FoxO signaling pathway_Homo sapiens_hsa040680.68548767
81Choline metabolism in cancer_Homo sapiens_hsa052310.66877079
82Endometrial cancer_Homo sapiens_hsa052130.64672382
83mTOR signaling pathway_Homo sapiens_hsa041500.64373252
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63099873
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.60156692
86Histidine metabolism_Homo sapiens_hsa003400.59580092
87Vitamin digestion and absorption_Homo sapiens_hsa049770.58045204
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56771227
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54970052
90Prostate cancer_Homo sapiens_hsa052150.53087760
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50757558
92HTLV-I infection_Homo sapiens_hsa051660.50685809
93Sphingolipid metabolism_Homo sapiens_hsa006000.50597671
94Type II diabetes mellitus_Homo sapiens_hsa049300.49491555
95Endocytosis_Homo sapiens_hsa041440.48907271
96Prolactin signaling pathway_Homo sapiens_hsa049170.48897057
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48549695
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.47914672
99Glycerolipid metabolism_Homo sapiens_hsa005610.47497359
100Inositol phosphate metabolism_Homo sapiens_hsa005620.47198098
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46941098
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46312485
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.45721595
104ErbB signaling pathway_Homo sapiens_hsa040120.44990127
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44523992
106Estrogen signaling pathway_Homo sapiens_hsa049150.43858154
107Fatty acid degradation_Homo sapiens_hsa000710.43715394
108Viral carcinogenesis_Homo sapiens_hsa052030.42578516
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42463092
110HIF-1 signaling pathway_Homo sapiens_hsa040660.41797987
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.40618409
112Bladder cancer_Homo sapiens_hsa052190.40423508
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40160254
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39715761
115Proteoglycans in cancer_Homo sapiens_hsa052050.39441238
116Insulin signaling pathway_Homo sapiens_hsa049100.39406115
117Type I diabetes mellitus_Homo sapiens_hsa049400.38710914
118Adherens junction_Homo sapiens_hsa045200.36785928
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35953667
120Epstein-Barr virus infection_Homo sapiens_hsa051690.34664058
121Autoimmune thyroid disease_Homo sapiens_hsa053200.34056870
122Fructose and mannose metabolism_Homo sapiens_hsa000510.32623053
123Tryptophan metabolism_Homo sapiens_hsa003800.32097945
124Focal adhesion_Homo sapiens_hsa045100.30679903
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30227256

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