TEPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.55272567
2intra-S DNA damage checkpoint (GO:0031573)8.95426088
3sperm-egg recognition (GO:0035036)8.86946569
4acrosome assembly (GO:0001675)8.65101946
5regulation of DNA endoreduplication (GO:0032875)8.51837866
6multicellular organism reproduction (GO:0032504)8.17412568
7binding of sperm to zona pellucida (GO:0007339)8.06435208
8synapsis (GO:0007129)8.02782565
9cell-cell recognition (GO:0009988)8.02252638
10spermatid development (GO:0007286)7.55218042
11epithelial cilium movement (GO:0003351)7.53702237
12reproduction (GO:0000003)7.22735777
13plasma membrane fusion (GO:0045026)7.20122049
14axonemal dynein complex assembly (GO:0070286)7.12027751
15motile cilium assembly (GO:0044458)7.01119229
16piRNA metabolic process (GO:0034587)6.60264515
17regulation of cilium movement (GO:0003352)6.25814118
18cilium movement (GO:0003341)5.77066863
19cilium or flagellum-dependent cell motility (GO:0001539)5.72826679
20negative regulation of inclusion body assembly (GO:0090084)5.72648409
21single fertilization (GO:0007338)5.68714956
22behavioral response to nicotine (GO:0035095)5.63044414
23meiotic cell cycle (GO:0051321)5.46530626
24chromosome organization involved in meiosis (GO:0070192)5.40937200
25spermatogenesis (GO:0007283)5.30808247
26male gamete generation (GO:0048232)5.28023349
27positive regulation of protein autophosphorylation (GO:0031954)5.21658252
28telomere maintenance via telomerase (GO:0007004)5.19646977
29male meiosis (GO:0007140)5.06257687
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.95848304
31sperm capacitation (GO:0048240)4.90893643
32synaptonemal complex organization (GO:0070193)4.87795019
33organic cation transport (GO:0015695)4.86466657
34gamete generation (GO:0007276)4.85377181
35fertilization (GO:0009566)4.72676881
36synaptonemal complex assembly (GO:0007130)4.69718423
37regulation of inclusion body assembly (GO:0090083)4.57603592
38DNA methylation involved in gamete generation (GO:0043046)4.45724652
39ventricular system development (GO:0021591)4.42568104
40microtubule severing (GO:0051013)4.39994163
41chromosome condensation (GO:0030261)4.33178079
42calcium ion-dependent exocytosis (GO:0017156)4.30266970
43sister chromatid cohesion (GO:0007062)4.25636266
44cell recognition (GO:0008037)4.22339952
45microtubule depolymerization (GO:0007019)4.17539232
46purine deoxyribonucleotide catabolic process (GO:0009155)4.12380237
47RNA-dependent DNA replication (GO:0006278)4.11952850
48platelet formation (GO:0030220)4.07122585
49mitotic G2 DNA damage checkpoint (GO:0007095)4.06216194
50cellular ketone body metabolic process (GO:0046950)4.03288433
51DNA packaging (GO:0006323)4.00754217
52fucose catabolic process (GO:0019317)4.00173764
53L-fucose metabolic process (GO:0042354)4.00173764
54L-fucose catabolic process (GO:0042355)4.00173764
55germ cell development (GO:0007281)4.00062050
56response to pheromone (GO:0019236)3.97248344
57sexual reproduction (GO:0019953)3.91367009
58cellular process involved in reproduction in multicellular organism (GO:0022412)3.90207507
59spermatid nucleus differentiation (GO:0007289)3.89358518
60multicellular organismal reproductive process (GO:0048609)3.79089564
61hydrogen peroxide biosynthetic process (GO:0050665)3.72019589
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.71805217
63NADH dehydrogenase complex assembly (GO:0010257)3.71805217
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71805217
65regulation of microtubule-based movement (GO:0060632)3.70404578
66cellular response to cadmium ion (GO:0071276)3.66508419
67protein complex biogenesis (GO:0070271)3.62457758
68left/right pattern formation (GO:0060972)3.62080896
69sequestering of actin monomers (GO:0042989)3.60890440
70ketone body metabolic process (GO:1902224)3.60853378
71DNA deamination (GO:0045006)3.60847763
72glycerol ether metabolic process (GO:0006662)3.60447080
73kidney morphogenesis (GO:0060993)3.49643173
74negative regulation of telomere maintenance (GO:0032205)3.45229456
75detection of light stimulus involved in sensory perception (GO:0050962)3.44351338
76detection of light stimulus involved in visual perception (GO:0050908)3.44351338
77negative regulation of DNA-dependent DNA replication (GO:2000104)3.43583843
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43442194
79reciprocal DNA recombination (GO:0035825)3.40269230
80reciprocal meiotic recombination (GO:0007131)3.40269230
81seminiferous tubule development (GO:0072520)3.38432042
82protein neddylation (GO:0045116)3.38341804
83water-soluble vitamin biosynthetic process (GO:0042364)3.37782971
84mitochondrial respiratory chain complex assembly (GO:0033108)3.37339471
85energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36015127
86ATP synthesis coupled proton transport (GO:0015986)3.36015127
87platelet dense granule organization (GO:0060155)3.35710127
88reactive oxygen species biosynthetic process (GO:1903409)3.31167142
89nonmotile primary cilium assembly (GO:0035058)3.30069804
90ether metabolic process (GO:0018904)3.27870578
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.26015466
92respiratory chain complex IV assembly (GO:0008535)3.25777136
93negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.21000371
94natural killer cell mediated immunity (GO:0002228)3.14656502
95natural killer cell mediated cytotoxicity (GO:0042267)3.14656502
96pyrimidine nucleobase catabolic process (GO:0006208)3.14636737
97respiratory burst (GO:0045730)3.14278777
98non-recombinational repair (GO:0000726)3.07567087
99double-strand break repair via nonhomologous end joining (GO:0006303)3.07567087
100multicellular organismal development (GO:0007275)3.06444344
101male meiosis I (GO:0007141)3.05702337
102regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.03071626
103protein-cofactor linkage (GO:0018065)2.98475929
104tryptophan catabolic process (GO:0006569)2.97682259
105indole-containing compound catabolic process (GO:0042436)2.97682259
106indolalkylamine catabolic process (GO:0046218)2.97682259
107positive regulation of CREB transcription factor activity (GO:0032793)2.94513271
108indolalkylamine metabolic process (GO:0006586)2.94256333
109kynurenine metabolic process (GO:0070189)2.92414536
110gamma-aminobutyric acid transport (GO:0015812)2.91810249
111mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88759964
112somite development (GO:0061053)2.87424095
113synaptic transmission, cholinergic (GO:0007271)2.86596332
114base-excision repair, AP site formation (GO:0006285)2.86001356
115photoreceptor cell maintenance (GO:0045494)2.85093203
116necroptotic process (GO:0070266)2.84833054
117axoneme assembly (GO:0035082)2.83778681
118superoxide anion generation (GO:0042554)2.83245470
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82992177
120regulation of action potential (GO:0098900)2.82545191
121nucleobase catabolic process (GO:0046113)2.82191556
122cytochrome complex assembly (GO:0017004)2.82145162
123regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80827360
124chaperone-mediated protein transport (GO:0072321)2.80441565
125cilium organization (GO:0044782)2.80415556
126neuronal action potential (GO:0019228)2.79505114
127establishment of protein localization to mitochondrial membrane (GO:0090151)2.79302667
128protein targeting to Golgi (GO:0000042)2.79194440
129protein refolding (GO:0042026)2.78601036
130regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.74391428
131cilium morphogenesis (GO:0060271)2.72918175
132mitotic G2/M transition checkpoint (GO:0044818)2.72866474
133preassembly of GPI anchor in ER membrane (GO:0016254)2.72618541
134ubiquinone biosynthetic process (GO:0006744)2.70989866
135cilium assembly (GO:0042384)2.70141318
136positive regulation of respiratory burst (GO:0060267)2.68980780
137response to acidic pH (GO:0010447)2.68470321
138mitotic sister chromatid cohesion (GO:0007064)2.67772002
139establishment of protein localization to Golgi (GO:0072600)2.66491011
140neuronal action potential propagation (GO:0019227)2.66365873
141retrograde transport, vesicle recycling within Golgi (GO:0000301)2.66200534
142protein polyglutamylation (GO:0018095)2.64992971
143negative regulation of mast cell activation (GO:0033004)2.62165283
144ubiquinone metabolic process (GO:0006743)2.61924777
145cAMP catabolic process (GO:0006198)2.60465551
146neural tube formation (GO:0001841)2.60435476
147mannosylation (GO:0097502)2.59762445
148regulation of rhodopsin mediated signaling pathway (GO:0022400)2.59261894
149nephron epithelium morphogenesis (GO:0072088)2.57734796
150nephron tubule morphogenesis (GO:0072078)2.57734796
151primary amino compound metabolic process (GO:1901160)2.56599279
152regulation of cilium assembly (GO:1902017)2.55883793
153protein localization to cilium (GO:0061512)2.54063814
154behavioral response to ethanol (GO:0048149)2.53684264
155rhodopsin mediated signaling pathway (GO:0016056)2.53678353
156response to muramyl dipeptide (GO:0032495)2.53048769
157tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52566954
158RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52566954
159transmission of nerve impulse (GO:0019226)2.51686273
160negative regulation of necroptotic process (GO:0060546)2.51448048
161glycerophospholipid catabolic process (GO:0046475)2.51189355
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49365806
163meiotic nuclear division (GO:0007126)2.48840321
164dendritic spine morphogenesis (GO:0060997)2.48689164
165nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48684434
166single strand break repair (GO:0000012)2.48501767
167retinal cone cell development (GO:0046549)2.47775352
168electron transport chain (GO:0022900)2.47694531
169cornea development in camera-type eye (GO:0061303)2.47268799
170nucleoside diphosphate phosphorylation (GO:0006165)2.47261391
171reflex (GO:0060004)2.46523428
172replication fork processing (GO:0031297)2.46167005
173tryptophan metabolic process (GO:0006568)2.44038768
174dopamine transport (GO:0015872)2.43603629
175spinal cord motor neuron differentiation (GO:0021522)2.42452749
176phosphatidylinositol acyl-chain remodeling (GO:0036149)2.40807896
177recombinational repair (GO:0000725)2.40731568
178exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.40698073
179sperm motility (GO:0030317)11.4090714
180cell wall macromolecule catabolic process (GO:0016998)11.1283959
181cell wall macromolecule metabolic process (GO:0044036)11.1283959
182acrosome reaction (GO:0007340)10.3877118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.31546489
2EZH2_22144423_ChIP-Seq_EOC_Human4.56156840
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.29856206
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17738216
5GBX2_23144817_ChIP-Seq_PC3_Human2.87732979
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66897195
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.53036954
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.37364174
9FUS_26573619_Chip-Seq_HEK293_Human2.27229184
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.25935677
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.16203550
12EWS_26573619_Chip-Seq_HEK293_Human2.15361028
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14239254
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10749793
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08508743
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02853184
17PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.99881057
18NFIB_24661679_ChIP-Seq_LUNG_Mouse1.99475900
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97060516
20P300_19829295_ChIP-Seq_ESCs_Human1.96225528
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92800293
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84723850
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77396310
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76118216
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.73582597
26ER_23166858_ChIP-Seq_MCF-7_Human1.73344573
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73329969
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68978238
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67967763
30IRF1_19129219_ChIP-ChIP_H3396_Human1.67373838
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.65505102
32CBP_20019798_ChIP-Seq_JUKART_Human1.62001176
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62001176
34IGF1R_20145208_ChIP-Seq_DFB_Human1.60560225
35TP53_22573176_ChIP-Seq_HFKS_Human1.55853956
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55002273
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54563050
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53443596
39GATA3_21867929_ChIP-Seq_CD8_Mouse1.52026844
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51153896
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50219271
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50219271
43CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49817177
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48144332
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47506918
46KDM2B_26808549_Chip-Seq_REH_Human1.46161408
47GATA1_26923725_Chip-Seq_HPCs_Mouse1.46010711
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.45346472
49ZNF274_21170338_ChIP-Seq_K562_Hela1.44242564
50VDR_24787735_ChIP-Seq_THP-1_Human1.44232284
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43920343
52MYC_18940864_ChIP-ChIP_HL60_Human1.42222122
53SOX2_19829295_ChIP-Seq_ESCs_Human1.41661849
54NANOG_19829295_ChIP-Seq_ESCs_Human1.41661849
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41596261
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.40709528
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40583501
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38551869
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.38551869
60AR_25329375_ChIP-Seq_VCAP_Human1.38417084
61BCAT_22108803_ChIP-Seq_LS180_Human1.36574931
62RNF2_27304074_Chip-Seq_NSC_Mouse1.33903605
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33525311
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33361402
65STAT1_17558387_ChIP-Seq_HELA_Human1.33169849
66ELK4_26923725_Chip-Seq_MESODERM_Mouse1.32099059
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.31644299
68SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31234083
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31121344
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30807083
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30793084
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30723604
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29652233
74GF1_26923725_Chip-Seq_HPCs_Mouse1.29583918
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28874761
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.28838945
77STAT3_23295773_ChIP-Seq_U87_Human1.28812994
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28605493
79TCF4_23295773_ChIP-Seq_U87_Human1.28311812
80SMAD4_21799915_ChIP-Seq_A2780_Human1.28057440
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.27562896
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27426842
83TCF4_22108803_ChIP-Seq_LS180_Human1.27407418
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.27164952
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26172464
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25315397
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22184796
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21849801
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.21793256
90VDR_22108803_ChIP-Seq_LS180_Human1.21658926
91RUNX2_22187159_ChIP-Seq_PCA_Human1.21458106
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20349365
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19833063
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19675143
95KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19313815
96REST_21632747_ChIP-Seq_MESCs_Mouse1.19074369
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18608879
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.18299475
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17742900
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.17412542
101SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17396821
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17176551
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16785648
104FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16651372
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16419156
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14979254
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14464360
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13744790
109P53_21459846_ChIP-Seq_SAOS-2_Human1.13652163
110CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13032249
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.12257431
112FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12131034
113* NCOR_22424771_ChIP-Seq_293T_Human1.11699145
114GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11641734
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.10618414
116* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09870980
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.09778460
118ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08796702
119SCL_19346495_ChIP-Seq_HPC-7_Human1.08630776
120AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08614832
121AR_20517297_ChIP-Seq_VCAP_Human1.07566595
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06689066
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06565855
124STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05363270
125SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05215354
126HOXB7_26014856_ChIP-Seq_BT474_Human1.05203426
127SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05168183
128REST_18959480_ChIP-ChIP_MESCs_Mouse1.04966704
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04768221
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.04726829
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04086574
132ERG_20517297_ChIP-Seq_VCAP_Human1.03839608
133MYB_26560356_Chip-Seq_TH2_Human1.03603884
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.03374390
135GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.01621289
136VDR_23849224_ChIP-Seq_CD4+_Human1.00649798
137EED_16625203_ChIP-ChIP_MESCs_Mouse1.00447846
138POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00365258
139GF1B_26923725_Chip-Seq_HPCs_Mouse0.99699503
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99320059
141* MYC_19829295_ChIP-Seq_ESCs_Human0.99207704
142VDR_24763502_ChIP-Seq_THP-1_Human0.98786562
143SMRT_27268052_Chip-Seq_Bcells_Human0.98218813
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.98189825
145RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97848350
146OCT1_27270436_Chip-Seq_PROSTATE_Human0.97742086
147JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97355122
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97204871
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97192510
150ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96985795
151JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96801867
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96407230
153ELK1_19687146_ChIP-ChIP_HELA_Human0.96348661
154ERA_21632823_ChIP-Seq_H3396_Human0.96318410
155TAF15_26573619_Chip-Seq_HEK293_Human0.96228105
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95668429
157SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95481226
158TAF2_19829295_ChIP-Seq_ESCs_Human0.95350708
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95277091
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95219635
161NANOG_20526341_ChIP-Seq_ESCs_Human0.94831216
162CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93761502
163FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93631400
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.93252786
165CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93108356
166GATA3_21867929_ChIP-Seq_TH1_Mouse0.92858888
167FLI1_27457419_Chip-Seq_LIVER_Mouse0.91192755
168NANOG_18555785_Chip-Seq_ESCs_Mouse0.91063195
169SPI1_20517297_ChIP-Seq_HL60_Human0.90263965
170FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89944692
171SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89919139
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89865385
173TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88800371
174CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88049519
175NFYB_21822215_ChIP-Seq_K562_Human0.87968092
176MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87795544
177LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82871760
178ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82570604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001879_abnormal_lymphatic_vessel4.15618640
2MP0002396_abnormal_hematopoietic_system4.03830068
3MP0003698_abnormal_male_reproductive3.90422549
4MP0004510_myositis3.84855093
5MP0001929_abnormal_gametogenesis3.50281630
6MP0002102_abnormal_ear_morphology3.19952328
7MP0005058_abnormal_lysosome_morphology2.80947309
8MP0008058_abnormal_DNA_repair2.74713578
9MP0000015_abnormal_ear_pigmentation2.59497497
10MP0002653_abnormal_ependyma_morphology2.49708407
11MP0005464_abnormal_platelet_physiology2.41143533
12MP0003303_peritoneal_inflammation2.40497509
13MP0005646_abnormal_pituitary_gland2.37101538
14MP0003195_calcinosis2.30322947
15MP0003880_abnormal_central_pattern2.28333621
16MP0002161_abnormal_fertility/fecundity2.22393606
17MP0003172_abnormal_lysosome_physiology2.05953555
18MP0005174_abnormal_tail_pigmentation2.03354015
19MP0001529_abnormal_vocalization2.01638427
20MP0005410_abnormal_fertilization11.6324948
21MP0003136_yellow_coat_color1.99430871
22MP0002638_abnormal_pupillary_reflex1.99377166
23MP0003436_decreased_susceptibility_to1.98826488
24MP0002837_dystrophic_cardiac_calcinosis1.98019464
25MP0001835_abnormal_antigen_presentation1.88281937
26MP0009745_abnormal_behavioral_response1.86174946
27MP0008872_abnormal_physiological_respon1.83709373
28MP0003787_abnormal_imprinting1.82591412
29MP0005645_abnormal_hypothalamus_physiol1.79375932
30MP0006072_abnormal_retinal_apoptosis1.76640745
31MP0002210_abnormal_sex_determination1.76624867
32MP0004142_abnormal_muscle_tone1.75973086
33MP0001485_abnormal_pinna_reflex1.75949643
34MP0001986_abnormal_taste_sensitivity1.74417663
35MP0000372_irregular_coat_pigmentation1.72842120
36MP0008877_abnormal_DNA_methylation1.71581040
37MP0004885_abnormal_endolymph1.69477424
38MP0002272_abnormal_nervous_system1.67576101
39MP0008875_abnormal_xenobiotic_pharmacok1.67404443
40MP0001486_abnormal_startle_reflex1.66964851
41MP0009785_altered_susceptibility_to1.64396038
42MP0004742_abnormal_vestibular_system1.62265003
43MP0002419_abnormal_innate_immunity1.61180603
44MP0002938_white_spotting1.59713810
45MP0000631_abnormal_neuroendocrine_gland1.59130816
46MP0004147_increased_porphyrin_level1.58205749
47MP0006082_CNS_inflammation1.57158419
48MP0008569_lethality_at_weaning1.56497850
49MP0006276_abnormal_autonomic_nervous1.52438052
50MP0004133_heterotaxia1.51699118
51MP0001984_abnormal_olfaction1.51542327
52MP0002735_abnormal_chemical_nociception1.49688439
53MP0001145_abnormal_male_reproductive1.48738048
54MP0002876_abnormal_thyroid_physiology1.45339792
55MP0003724_increased_susceptibility_to1.44800928
56MP0002572_abnormal_emotion/affect_behav1.42378289
57MP0002234_abnormal_pharynx_morphology1.41790289
58MP0005025_abnormal_response_to1.35312419
59MP0003646_muscle_fatigue1.35170102
60MP0000569_abnormal_digit_pigmentation1.34845150
61MP0000778_abnormal_nervous_system1.34465401
62MP0002452_abnormal_antigen_presenting1.33186494
63MP0002064_seizures1.32848365
64MP0003718_maternal_effect1.31447847
65MP0005423_abnormal_somatic_nervous1.31434032
66MP0005000_abnormal_immune_tolerance1.29463995
67MP0004043_abnormal_pH_regulation1.28548831
68MP0002733_abnormal_thermal_nociception1.28027152
69MP0003878_abnormal_ear_physiology1.26650825
70MP0005377_hearing/vestibular/ear_phenot1.26650825
71MP0002723_abnormal_immune_serum1.25876787
72MP0002928_abnormal_bile_duct1.25175455
73MP0001970_abnormal_pain_threshold1.24206229
74MP0000427_abnormal_hair_cycle1.23631588
75MP0000653_abnormal_sex_gland1.20592381
76MP0002693_abnormal_pancreas_physiology1.18366676
77MP0004924_abnormal_behavior1.15949321
78MP0005386_behavior/neurological_phenoty1.15949321
79MP0001819_abnormal_immune_cell1.15035532
80MP0002420_abnormal_adaptive_immunity1.13557032
81MP0002067_abnormal_sensory_capabilities1.13230331
82MP0002148_abnormal_hypersensitivity_rea1.12805921
83MP0001501_abnormal_sleep_pattern1.12547122
84MP0001905_abnormal_dopamine_level1.10879367
85MP0001293_anophthalmia1.10186604
86MP0010386_abnormal_urinary_bladder1.09775112
87MP0005671_abnormal_response_to1.09013410
88MP0000026_abnormal_inner_ear1.08548380
89MP0003448_altered_tumor_morphology1.08023975
90MP0001919_abnormal_reproductive_system1.07594072
91MP0008789_abnormal_olfactory_epithelium1.05946905
92MP0003635_abnormal_synaptic_transmissio1.05558879
93MP0005389_reproductive_system_phenotype1.04860776
94MP0005195_abnormal_posterior_eye1.04711155
95MP0010155_abnormal_intestine_physiology1.04547449
96MP0001800_abnormal_humoral_immune1.04448857
97MP0002752_abnormal_somatic_nervous1.01743057
98MP0000249_abnormal_blood_vessel1.01565490
99MP0001502_abnormal_circadian_rhythm1.00745072
100MP0002282_abnormal_trachea_morphology0.99029488
101MP0002063_abnormal_learning/memory/cond0.98445908
102MP0001963_abnormal_hearing_physiology0.94887156
103MP0006292_abnormal_olfactory_placode0.94722851
104MP0002405_respiratory_system_inflammati0.90775429
105MP0005409_darkened_coat_color0.89973979
106MP0002734_abnormal_mechanical_nocicepti0.89245009
107MP0003121_genomic_imprinting0.88707750
108MP0005387_immune_system_phenotype0.88535483
109MP0001790_abnormal_immune_system0.88535483
110MP0001324_abnormal_eye_pigmentation0.86774723
111MP0000685_abnormal_immune_system0.86220764
112MP0003137_abnormal_impulse_conducting0.85973448
113MP0004808_abnormal_hematopoietic_stem0.85652693
114MP0001845_abnormal_inflammatory_respons0.84991719
115MP0005085_abnormal_gallbladder_physiolo0.84912157
116MP0002177_abnormal_outer_ear0.84474562
117MP0005167_abnormal_blood-brain_barrier0.84329813
118MP0009046_muscle_twitch0.84294793
119MP0003122_maternal_imprinting0.83719444
120MP0002184_abnormal_innervation0.83695226
121MP0005391_vision/eye_phenotype0.83399429
122MP0002398_abnormal_bone_marrow0.82643368
123MP0002751_abnormal_autonomic_nervous0.82277977
124MP0005394_taste/olfaction_phenotype0.82177272
125MP0005499_abnormal_olfactory_system0.82177272
126MP0000716_abnormal_immune_system0.82090479
127MP0000647_abnormal_sebaceous_gland0.81492351
128MP0002736_abnormal_nociception_after0.81200161
129MP0000049_abnormal_middle_ear0.80290201
130MP0002229_neurodegeneration0.80190259
131MP0005075_abnormal_melanosome_morpholog0.79956405
132MP0000566_synostosis0.78885652
133MP0002882_abnormal_neuron_morphology0.75925890
134MP0010094_abnormal_chromosome_stability0.75287370
135MP0002095_abnormal_skin_pigmentation0.74327192
136MP0005253_abnormal_eye_physiology0.73410397
137MP0003119_abnormal_digestive_system0.73141017
138MP0008469_abnormal_protein_level0.72918988
139MP0001533_abnormal_skeleton_physiology0.71927176
140MP0005076_abnormal_cell_differentiation0.71753095
141MP0002998_abnormal_bone_remodeling0.71614166
142MP0003300_gastrointestinal_ulcer0.68964277
143MP0001851_eye_inflammation0.68665639
144MP0009278_abnormal_bone_marrow0.68400091
145MP0002429_abnormal_blood_cell0.68045151
146MP0003011_delayed_dark_adaptation0.64781415
147MP0003075_altered_response_to0.64014998
148MP0000230_abnormal_systemic_arterial0.63042908
149MP0001545_abnormal_hematopoietic_system0.61665732
150MP0005397_hematopoietic_system_phenotyp0.61665732
151MP0005551_abnormal_eye_electrophysiolog0.61369004
152MP0001968_abnormal_touch/_nociception0.59457145
153MP0000920_abnormal_myelination0.58467092
154MP0001765_abnormal_ion_homeostasis0.57189850
155MP0009333_abnormal_splenocyte_physiolog0.54422402
156MP0001944_abnormal_pancreas_morphology0.53399248
157MP0005670_abnormal_white_adipose0.52321699
158MP0005084_abnormal_gallbladder_morpholo0.51725514
159MP0000689_abnormal_spleen_morphology0.47600921
160MP0005395_other_phenotype0.45990516
161MP0001727_abnormal_embryo_implantation0.45483880
162MP0003890_abnormal_embryonic-extraembry0.45311946
163MP0002722_abnormal_immune_system0.44808255
164MP0005164_abnormal_response_to0.44648611
165MP0003690_abnormal_glial_cell0.43795542
166MP0005623_abnormal_meninges_morphology0.43612850
167MP0002160_abnormal_reproductive_system0.43448626
168MP0003183_abnormal_peptide_metabolism0.43168116
169MP0004883_abnormal_blood_vessel0.42884860
170MP0005166_decreased_susceptibility_to0.42172367
171MP0000750_abnormal_muscle_regeneration0.41587898
172MP0002090_abnormal_vision0.41004565
173MP0003634_abnormal_glial_cell0.40352069
174MP0001299_abnormal_eye_distance/0.38171429
175MP0002557_abnormal_social/conspecific_i0.38158388

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.15974982
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.14008592
3Absent/shortened dynein arms (HP:0200106)9.14008592
4Frequent falls (HP:0002359)6.62310218
5Abnormal respiratory motile cilium physiology (HP:0012261)6.39844750
6Abnormal respiratory epithelium morphology (HP:0012253)6.26811561
7Abnormal respiratory motile cilium morphology (HP:0005938)6.26811561
8Rhinitis (HP:0012384)5.71498252
9Chronic bronchitis (HP:0004469)5.46549078
10Nasal polyposis (HP:0100582)5.34465795
11Eczematoid dermatitis (HP:0000976)5.31320290
12Infertility (HP:0000789)5.20536368
13Recurrent gram-negative bacterial infections (HP:0005420)4.96528066
14Abnormality of the nasal mucosa (HP:0000433)4.61586792
15Abnormal ciliary motility (HP:0012262)4.48624146
16Pancreatic cysts (HP:0001737)4.41634595
17Pancreatic fibrosis (HP:0100732)4.39354613
18True hermaphroditism (HP:0010459)4.20977648
19Impaired smooth pursuit (HP:0007772)4.08044660
20Bronchitis (HP:0012387)3.97856228
21Recurrent abscess formation (HP:0002722)3.88823637
22Congenital stationary night blindness (HP:0007642)3.75305720
23Dysdiadochokinesis (HP:0002075)3.67678713
24Recurrent bacterial skin infections (HP:0005406)3.51267543
25Vacuolated lymphocytes (HP:0001922)3.50980878
26Bronchiectasis (HP:0002110)3.50642346
27Abnormality of ocular smooth pursuit (HP:0000617)3.41557408
28Chronic hepatic failure (HP:0100626)3.36677605
29Gaze-evoked nystagmus (HP:0000640)3.35816914
30J-shaped sella turcica (HP:0002680)3.35456682
31Nephronophthisis (HP:0000090)3.32328037
32Abnormality of saccadic eye movements (HP:0000570)3.25804349
33Hyperventilation (HP:0002883)3.15367137
34Male infertility (HP:0003251)3.14744577
35Recurrent bronchitis (HP:0002837)2.98727661
36Abnormality of the renal cortex (HP:0011035)2.97514945
37Mediastinal lymphadenopathy (HP:0100721)2.96644431
38Spondylolisthesis (HP:0003302)2.91643279
39Cystic liver disease (HP:0006706)2.91075903
40Recurrent sinusitis (HP:0011108)2.88844467
41Oculomotor apraxia (HP:0000657)2.85022265
42Decreased central vision (HP:0007663)2.82785114
43Acute necrotizing encephalopathy (HP:0006965)2.81936717
44Sclerocornea (HP:0000647)2.80128588
45Chronic obstructive pulmonary disease (HP:0006510)2.74655625
46Obstructive lung disease (HP:0006536)2.74655625
47Inability to walk (HP:0002540)2.74609331
48Recurrent otitis media (HP:0000403)2.68741741
49Abnormal spermatogenesis (HP:0008669)2.60535419
50Severe visual impairment (HP:0001141)2.59589451
51Mitochondrial inheritance (HP:0001427)2.58118998
52Abnormality of macrophages (HP:0004311)2.56815483
53Anencephaly (HP:0002323)2.55817808
54Congenital, generalized hypertrichosis (HP:0004540)2.53669367
55Dysostosis multiplex (HP:0000943)2.52750542
56Tubular atrophy (HP:0000092)2.51536277
57Elevated erythrocyte sedimentation rate (HP:0003565)2.49996959
58Progressive macrocephaly (HP:0004481)2.48872055
59Lissencephaly (HP:0001339)2.46950497
60Abnormality of the renal medulla (HP:0100957)2.46074916
61Pendular nystagmus (HP:0012043)2.46037820
62Acute encephalopathy (HP:0006846)2.45577819
63Tubulointerstitial fibrosis (HP:0005576)2.43437183
64Gait imbalance (HP:0002141)2.42910413
65Abnormal mitochondria in muscle tissue (HP:0008316)2.41990139
66Orchitis (HP:0100796)2.39258285
67Recurrent skin infections (HP:0001581)2.38976726
68Broad-based gait (HP:0002136)2.37862510
69Increased CSF lactate (HP:0002490)2.37651792
70Cellulitis (HP:0100658)2.36182053
71Abnormal biliary tract physiology (HP:0012439)2.36060386
72Bile duct proliferation (HP:0001408)2.36060386
73Recurrent fungal infections (HP:0002841)2.35640678
74Deformed sella turcica (HP:0002681)2.31548354
75Retinal dysplasia (HP:0007973)2.31217321
76Congenital hepatic fibrosis (HP:0002612)2.29811810
773-Methylglutaconic aciduria (HP:0003535)2.29571884
78Congenital primary aphakia (HP:0007707)2.28441938
79Polyuria (HP:0000103)2.27683856
80Gingivitis (HP:0000230)2.26570071
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.25240219
82Furrowed tongue (HP:0000221)2.24622237
83Optic nerve hypoplasia (HP:0000609)2.24171863
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24075909
85Abnormality of midbrain morphology (HP:0002418)2.24042450
86Molar tooth sign on MRI (HP:0002419)2.24042450
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.22682961
88Nephrogenic diabetes insipidus (HP:0009806)2.19851631
89Increased corneal curvature (HP:0100692)2.19234836
90Keratoconus (HP:0000563)2.19234836
91Optic neuritis (HP:0100653)2.19097227
92Retrobulbar optic neuritis (HP:0100654)2.19097227
93Hemiparesis (HP:0001269)2.18239825
94Myositis (HP:0100614)2.17308851
95Male pseudohermaphroditism (HP:0000037)2.17137403
96Optic disc pallor (HP:0000543)2.16571635
97Dyschromatopsia (HP:0007641)2.16130619
98Abnormality of the sella turcica (HP:0002679)2.16116253
99Bony spicule pigmentary retinopathy (HP:0007737)2.16041051
100Lipid accumulation in hepatocytes (HP:0006561)2.15682135
101Increased cerebral lipofuscin (HP:0011813)2.15566121
102Abnormality of alanine metabolism (HP:0010916)2.11905199
103Hyperalaninemia (HP:0003348)2.11905199
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11905199
105Cerebellar dysplasia (HP:0007033)2.10998116
106Disinhibition (HP:0000734)2.10689438
107Tubulointerstitial abnormality (HP:0001969)2.10023181
108Recurrent cutaneous fungal infections (HP:0011370)2.09761356
109Chronic mucocutaneous candidiasis (HP:0002728)2.09761356
110Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09348065
111Postaxial foot polydactyly (HP:0001830)2.07783007
112Increased hepatocellular lipid droplets (HP:0006565)2.06342559
113Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05202492
114Abnormality of the labia minora (HP:0012880)2.04329222
115Stomach cancer (HP:0012126)2.02971244
116Renal cortical cysts (HP:0000803)2.02496765
117Progressive inability to walk (HP:0002505)2.01350970
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01094490
119Hepatocellular necrosis (HP:0001404)2.00370773
120Large for gestational age (HP:0001520)1.99100842
121Occipital encephalocele (HP:0002085)1.98441826
122Loss of speech (HP:0002371)1.97834958
123Hypoplasia of the fovea (HP:0007750)1.93692178
124Aplasia/Hypoplasia of the fovea (HP:0008060)1.93692178
125Genital tract atresia (HP:0001827)1.93490976
126Progressive cerebellar ataxia (HP:0002073)1.93198366
127Focal motor seizures (HP:0011153)1.92974669
128Abolished electroretinogram (ERG) (HP:0000550)1.92639106
129Mutism (HP:0002300)1.91073645
130Hepatic necrosis (HP:0002605)1.90913183
131Stomatitis (HP:0010280)1.90538738
132Abnormal urine output (HP:0012590)1.89959668
133Broad face (HP:0000283)1.89898466
134Meningitis (HP:0001287)1.89347803
135Postaxial hand polydactyly (HP:0001162)1.88693900
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.85635871
137Osteomyelitis (HP:0002754)1.84970739
138Methylmalonic aciduria (HP:0012120)1.84562615
139Vaginal atresia (HP:0000148)1.84532531
140Chronic sinusitis (HP:0011109)1.84317114
141Concave nail (HP:0001598)1.83868474
142Pachygyria (HP:0001302)1.83793932
143Attenuation of retinal blood vessels (HP:0007843)1.82149737
144Double outlet right ventricle (HP:0001719)1.81437725
145Congenital malformation of the right heart (HP:0011723)1.81437725
146Decreased circulating renin level (HP:0003351)1.80310383
147Abnormal rod and cone electroretinograms (HP:0008323)1.77189227
148Polyphagia (HP:0002591)1.76029650
149Severe muscular hypotonia (HP:0006829)1.75742646
150Aplasia/hypoplasia of the uterus (HP:0008684)1.75573691
151Thyroid-stimulating hormone excess (HP:0002925)1.74704872
152Patellar aplasia (HP:0006443)1.74327363
153Renal Fanconi syndrome (HP:0001994)1.72640788
154Abnormality of macular pigmentation (HP:0008002)1.71850169
155Fair hair (HP:0002286)1.71486215
156Azoospermia (HP:0000027)1.71415567
157Limb dystonia (HP:0002451)1.70935156
158Prominent metopic ridge (HP:0005487)1.70397772
159Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68721772
160Beaking of vertebral bodies (HP:0004568)1.61862085
161Truncal obesity (HP:0001956)1.60297822
162Porencephaly (HP:0002132)1.59997164
163Type II lissencephaly (HP:0007260)1.57838881
164Recurrent viral infections (HP:0004429)1.57123219
165Abnormality of the frontal sinuses (HP:0002687)1.53576670
166Constricted visual fields (HP:0001133)1.52830828
167Stage 5 chronic kidney disease (HP:0003774)1.52169545
168Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.50950484
169Hepatosplenomegaly (HP:0001433)1.50883582
170Polydipsia (HP:0001959)1.49303821
171Abnormal drinking behavior (HP:0030082)1.49303821
172Recurrent pneumonia (HP:0006532)1.47629973
173Medial flaring of the eyebrow (HP:0010747)1.47325371
174Retinal atrophy (HP:0001105)1.46925059
175Abnormality of the metopic suture (HP:0005556)1.43803919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.42409515
2PDK45.42409515
3TESK15.40572034
4FRK4.10050117
5PDK23.66913118
6PRKD33.38948529
7ICK2.95204085
8MAP4K22.91925042
9ADRBK22.84493208
10MAP3K132.83177365
11MAP3K142.77361619
12WNK32.76308807
13BMPR1B2.65142656
14TLK12.61845816
15CAMKK12.53754191
16ZAK2.44066540
17TNIK2.26755840
18MAP3K102.24404665
19NUAK12.22828880
20RIPK42.22451522
21STK382.20009846
22GRK12.19768704
23BLK2.11000789
24CASK1.96866053
25PASK1.95842284
26INSRR1.94625722
27PINK11.94598630
28DYRK1B1.87030025
29MAPK131.79194802
30ACVR1B1.74966617
31PBK1.71453624
32DYRK21.68798753
33ABL21.66969526
34MAP3K41.63490318
35DAPK21.61980406
36MARK11.60071387
37IKBKE1.57220110
38PTK2B1.56821637
39PAK31.55911732
40FES1.51933993
41TAOK31.46707234
42TIE11.43950579
43DYRK31.39621894
44TBK11.39530879
45OXSR11.37512242
46CSNK1G21.35468172
47KIT1.32626400
48STK161.32443585
49KSR21.28835181
50TRIM281.26545065
51ERBB31.25964517
52TGFBR21.25528229
53CSNK1G31.23184698
54PLK41.22292383
55CSNK1G11.21204818
56CDK191.15236360
57MAPK151.15048583
58TSSK61.13135808
59VRK11.11651103
60PLK21.11470889
61PRKCG1.10337410
62BCKDK1.09740593
63EPHA41.06247815
64ADRBK11.04329573
65MAP2K71.04119409
66TYK21.03931240
67FGFR21.02800188
68MAP4K11.02153101
69CSNK1A1L1.00603791
70BCR1.00465903
71MKNK20.99033901
72PDK10.98024060
73IKBKB0.95925945
74WNK40.94294456
75MST40.93887888
76PRKCE0.93727242
77STK38L0.87430659
78NTRK30.82891973
79ERN10.82867795
80GRK70.78547872
81ZAP700.77852223
82PHKG10.77679354
83PHKG20.77679354
84UHMK10.77385488
85STK100.77136643
86PLK30.74920107
87TGFBR10.73523640
88MAPKAPK50.73174555
89YES10.69316755
90MAP3K110.69103286
91CAMKK20.67877819
92IRAK10.67317932
93CSNK1D0.66033310
94PDGFRB0.65733564
95VRK20.65319102
96CAMK2A0.65167967
97MAPK40.64984040
98STK390.64369105
99RPS6KA50.63977101
100SYK0.63286196
101LCK0.62217295
102NLK0.61353215
103PRKCQ0.61228876
104TAF10.60738604
105STK30.59747513
106STK110.59393146
107CDK80.58691623
108HCK0.57573899
109PKN10.57347569
110CCNB10.57061081
111MOS0.56303848
112EEF2K0.55826055
113NEK20.55376606
114KDR0.54755652
115CSNK1A10.54025658
116WNK10.53152143
117PRKACA0.52196003
118MKNK10.51374046
119WEE10.50784763
120PIK3CA0.50611617
121DYRK1A0.46806567
122ERBB20.45149785
123MAP2K60.44432521
124EGFR0.43781286
125PRKCD0.42766186
126MAP3K120.42426359
127MAPKAPK30.41531985
128MAP3K10.41526013
129PLK10.41518087
130PRKCZ0.40675995
131PDPK10.39928499
132JAK20.39431622
133PRKCA0.38057723
134MAP3K50.37364668
135RPS6KC10.37255713
136RPS6KL10.37255713
137PRKG10.36202045
138LYN0.35933905
139MAP3K20.35546556
140TYRO30.35333151
141CDK90.35156170
142PRKCI0.34725120
143BUB10.33151642
144TXK0.33103456
145CAMK10.32807633
146GRK50.32387477
147EPHA30.32332900
148CHUK0.31959268
149SGK20.31804807
150RPS6KA60.31504178
151MAP3K70.30512401
152SGK4940.30329275
153SGK2230.30329275
154ITK0.29053518
155CSNK2A20.28680279
156MUSK0.28155175
157MAPK70.27557874
158HIPK20.27430602
159CSK0.24932895
160ABL10.24570880
161KSR10.23071234
162ATM0.21563736
163CSF1R0.21321247
164PNCK0.21040040
165PIM10.19492428
166ARAF0.18525957
167RPS6KA10.18203007
168PRKDC0.17855705
169PAK60.17551327
170BRSK20.16798525
171NTRK20.16604585
172EPHB20.15099177
173MARK20.14989769
174CAMK1G0.14599058
175INSR0.13850657
176MINK10.12660511
177PRKACG0.12493429
178TEC0.11985080

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034505.54408480
2Oxidative phosphorylation_Homo sapiens_hsa001903.14237707
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91617544
4Dorso-ventral axis formation_Homo sapiens_hsa043202.57300338
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54438539
6Homologous recombination_Homo sapiens_hsa034402.52659123
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.51373763
8Parkinsons disease_Homo sapiens_hsa050122.41089656
9Nitrogen metabolism_Homo sapiens_hsa009102.39719148
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28452614
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23193200
12Protein export_Homo sapiens_hsa030602.21227219
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.18268882
14B cell receptor signaling pathway_Homo sapiens_hsa046622.16212125
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.08673682
16Osteoclast differentiation_Homo sapiens_hsa043802.05804831
17Butanoate metabolism_Homo sapiens_hsa006502.04744524
18Leishmaniasis_Homo sapiens_hsa051402.02104343
19Nicotine addiction_Homo sapiens_hsa050331.93943048
20Other glycan degradation_Homo sapiens_hsa005111.93695925
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77631290
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74593237
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70379064
24Caffeine metabolism_Homo sapiens_hsa002321.70331359
25RNA polymerase_Homo sapiens_hsa030201.63901955
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62252184
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.60186185
28Alzheimers disease_Homo sapiens_hsa050101.57204361
29Selenocompound metabolism_Homo sapiens_hsa004501.56428237
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49035584
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.46315623
32Tryptophan metabolism_Homo sapiens_hsa003801.46311951
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45822299
34Propanoate metabolism_Homo sapiens_hsa006401.45068308
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38024222
36Basal transcription factors_Homo sapiens_hsa030221.37000605
37Morphine addiction_Homo sapiens_hsa050321.36871572
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34544744
39Phagosome_Homo sapiens_hsa041451.31553316
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29002911
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28675514
42T cell receptor signaling pathway_Homo sapiens_hsa046601.27900101
43Estrogen signaling pathway_Homo sapiens_hsa049151.27031373
44TNF signaling pathway_Homo sapiens_hsa046681.26050004
45Fanconi anemia pathway_Homo sapiens_hsa034601.25062582
46Antigen processing and presentation_Homo sapiens_hsa046121.23608321
47Type II diabetes mellitus_Homo sapiens_hsa049301.23598175
48Taste transduction_Homo sapiens_hsa047421.22530623
49Toxoplasmosis_Homo sapiens_hsa051451.22127128
50RNA degradation_Homo sapiens_hsa030181.20512874
51Cardiac muscle contraction_Homo sapiens_hsa042601.20367022
52Ribosome_Homo sapiens_hsa030101.16748117
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16205162
54Legionellosis_Homo sapiens_hsa051341.15301525
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14513230
56Regulation of autophagy_Homo sapiens_hsa041401.14220966
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13324005
58Peroxisome_Homo sapiens_hsa041461.11611678
59Glucagon signaling pathway_Homo sapiens_hsa049221.09845576
60Proteasome_Homo sapiens_hsa030501.09653361
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08648746
62Intestinal immune network for IgA production_Homo sapiens_hsa046721.08380808
63Central carbon metabolism in cancer_Homo sapiens_hsa052301.07826969
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06417556
65Rheumatoid arthritis_Homo sapiens_hsa053231.05188572
66One carbon pool by folate_Homo sapiens_hsa006701.05107263
67Measles_Homo sapiens_hsa051621.04324319
68Fatty acid biosynthesis_Homo sapiens_hsa000611.02813125
69Collecting duct acid secretion_Homo sapiens_hsa049661.02105800
70Acute myeloid leukemia_Homo sapiens_hsa052211.02009882
71Steroid biosynthesis_Homo sapiens_hsa001001.01575039
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99699945
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99660881
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99235614
75VEGF signaling pathway_Homo sapiens_hsa043700.99193860
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.98138016
77GABAergic synapse_Homo sapiens_hsa047270.98099294
78Serotonergic synapse_Homo sapiens_hsa047260.96194584
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96112752
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93523473
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.92700042
82Pentose phosphate pathway_Homo sapiens_hsa000300.92567289
83Influenza A_Homo sapiens_hsa051640.92252389
84Lysosome_Homo sapiens_hsa041420.90921856
85Renal cell carcinoma_Homo sapiens_hsa052110.90836070
86Salmonella infection_Homo sapiens_hsa051320.90102061
87Retinol metabolism_Homo sapiens_hsa008300.89445207
88Shigellosis_Homo sapiens_hsa051310.88964490
89Glutamatergic synapse_Homo sapiens_hsa047240.88693488
90Synaptic vesicle cycle_Homo sapiens_hsa047210.88604385
91Arachidonic acid metabolism_Homo sapiens_hsa005900.87289501
92Purine metabolism_Homo sapiens_hsa002300.86053724
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84882210
94Tuberculosis_Homo sapiens_hsa051520.84479316
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83573565
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.83299877
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82989680
98Apoptosis_Homo sapiens_hsa042100.82751592
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81685134
100Asthma_Homo sapiens_hsa053100.81407702
101Renin secretion_Homo sapiens_hsa049240.80592898
102Chemical carcinogenesis_Homo sapiens_hsa052040.79708935
103Chronic myeloid leukemia_Homo sapiens_hsa052200.78923044
104Cholinergic synapse_Homo sapiens_hsa047250.78371935
105Thyroid hormone synthesis_Homo sapiens_hsa049180.77837170
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.77647944
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77555921
108Insulin secretion_Homo sapiens_hsa049110.77531583
109Endocytosis_Homo sapiens_hsa041440.76748760
110Ether lipid metabolism_Homo sapiens_hsa005650.75480601
111Colorectal cancer_Homo sapiens_hsa052100.74437598
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72703846
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72349218
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71965307
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71627327
116Platelet activation_Homo sapiens_hsa046110.71478310
117Linoleic acid metabolism_Homo sapiens_hsa005910.69792243
118Sulfur relay system_Homo sapiens_hsa041220.69422861
119Metabolic pathways_Homo sapiens_hsa011000.68391250
120Olfactory transduction_Homo sapiens_hsa047400.67558362
121Amphetamine addiction_Homo sapiens_hsa050310.67319855
122Inositol phosphate metabolism_Homo sapiens_hsa005620.66784544
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65876122
124HIF-1 signaling pathway_Homo sapiens_hsa040660.65548618
125Endometrial cancer_Homo sapiens_hsa052130.65435294
126Staphylococcus aureus infection_Homo sapiens_hsa051500.64735964
127Hepatitis B_Homo sapiens_hsa051610.64422486
128Renin-angiotensin system_Homo sapiens_hsa046140.64020116
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63986881
130Fat digestion and absorption_Homo sapiens_hsa049750.63794950
131Type I diabetes mellitus_Homo sapiens_hsa049400.62363555
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60149123
133Pyrimidine metabolism_Homo sapiens_hsa002400.59916515
134Chemokine signaling pathway_Homo sapiens_hsa040620.59686103
135Dopaminergic synapse_Homo sapiens_hsa047280.59481547
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59287309
137Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58857388
138beta-Alanine metabolism_Homo sapiens_hsa004100.58230945
139Folate biosynthesis_Homo sapiens_hsa007900.57679956
140Prolactin signaling pathway_Homo sapiens_hsa049170.57546053
141Vibrio cholerae infection_Homo sapiens_hsa051100.57357971
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56816348
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56460662
144ABC transporters_Homo sapiens_hsa020100.55910319
145Pertussis_Homo sapiens_hsa051330.54757726
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.54323818
147Oxytocin signaling pathway_Homo sapiens_hsa049210.53613880
148Ovarian steroidogenesis_Homo sapiens_hsa049130.53410975
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52803649
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.50551233
151Vitamin digestion and absorption_Homo sapiens_hsa049770.50050575
152Prostate cancer_Homo sapiens_hsa052150.49895160
153Primary immunodeficiency_Homo sapiens_hsa053400.49134650
154cAMP signaling pathway_Homo sapiens_hsa040240.46811205
155Hematopoietic cell lineage_Homo sapiens_hsa046400.46583150
156Glioma_Homo sapiens_hsa052140.46390892
157Glycerolipid metabolism_Homo sapiens_hsa005610.45847474
158Pancreatic cancer_Homo sapiens_hsa052120.43522195
159Hedgehog signaling pathway_Homo sapiens_hsa043400.43293213
160Cocaine addiction_Homo sapiens_hsa050300.42736593
161Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41988448
162Calcium signaling pathway_Homo sapiens_hsa040200.41737064
163Neurotrophin signaling pathway_Homo sapiens_hsa047220.41508736
164Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40990554
165Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40828509
166Nucleotide excision repair_Homo sapiens_hsa034200.40627568
167Phototransduction_Homo sapiens_hsa047440.39775248
168Base excision repair_Homo sapiens_hsa034100.39765365
169Circadian rhythm_Homo sapiens_hsa047100.39261310
170Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38662968
171Huntingtons disease_Homo sapiens_hsa050160.38647698
172Fatty acid degradation_Homo sapiens_hsa000710.38407084
173Phospholipase D signaling pathway_Homo sapiens_hsa040720.38366983
174Circadian entrainment_Homo sapiens_hsa047130.38346771
175Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37389135
176Salivary secretion_Homo sapiens_hsa049700.37171740
177Long-term depression_Homo sapiens_hsa047300.36598607
178Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35816228
179Graft-versus-host disease_Homo sapiens_hsa053320.35803434
180Arginine and proline metabolism_Homo sapiens_hsa003300.35308887
181Autoimmune thyroid disease_Homo sapiens_hsa053200.33983434
182Allograft rejection_Homo sapiens_hsa053300.33550724
183Basal cell carcinoma_Homo sapiens_hsa052170.32896189
184Cysteine and methionine metabolism_Homo sapiens_hsa002700.32775914

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