TEPSIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.55292475
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.55292475
3positive regulation of gamma-delta T cell activation (GO:0046645)5.22689358
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.21366949
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.10358827
6antigen processing and presentation of endogenous antigen (GO:0019883)5.08633519
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.83658067
8negative regulation of erythrocyte differentiation (GO:0045647)4.61620146
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48841709
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.48841709
11modulation by symbiont of host immune response (GO:0052553)4.48841709
12positive regulation by symbiont of host defense response (GO:0052509)4.48841709
13modulation by symbiont of host defense response (GO:0052031)4.48841709
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48841709
15detection of bacterium (GO:0016045)4.42989749
16detection of other organism (GO:0098543)4.42384703
17response to peptidoglycan (GO:0032494)4.22307280
18leukocyte aggregation (GO:0070486)4.16282618
19neutrophil activation involved in immune response (GO:0002283)3.96357637
20regulation of gamma-delta T cell activation (GO:0046643)3.96193869
21macrophage activation involved in immune response (GO:0002281)3.92733950
22regulation of B cell receptor signaling pathway (GO:0050855)3.84606038
23response to muramyl dipeptide (GO:0032495)3.84260675
24positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.79324266
25positive thymic T cell selection (GO:0045059)3.77629799
26regulation of T-helper 2 cell differentiation (GO:0045628)3.77284076
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.73719887
28mannose metabolic process (GO:0006013)3.72092186
29thymic T cell selection (GO:0045061)3.62235619
30detection of external biotic stimulus (GO:0098581)3.61542974
31negative regulation of interleukin-12 production (GO:0032695)3.57148502
32regulation of gamma-delta T cell differentiation (GO:0045586)3.55172276
33immunoglobulin mediated immune response (GO:0016064)3.54475617
34regulation of interferon-beta biosynthetic process (GO:0045357)3.53519654
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.52439602
36germinal center formation (GO:0002467)3.47523826
37NIK/NF-kappaB signaling (GO:0038061)3.45012322
38negative thymic T cell selection (GO:0045060)3.38735803
39T cell selection (GO:0045058)3.37406659
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.36150668
41cellular extravasation (GO:0045123)3.33567501
42regulation of mast cell degranulation (GO:0043304)3.31880190
43B cell receptor signaling pathway (GO:0050853)3.30879708
44negative regulation of T-helper cell differentiation (GO:0045623)3.29053228
45negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.29053228
46detection of biotic stimulus (GO:0009595)3.19359600
47negative regulation of type 2 immune response (GO:0002829)3.19137277
48negative T cell selection (GO:0043383)3.18650756
49antigen processing and presentation via MHC class Ib (GO:0002475)3.17795615
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.17066981
51regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16442011
52negative regulation of leukocyte mediated immunity (GO:0002704)3.14882076
53regulation of leukocyte degranulation (GO:0043300)3.12916712
54regulation of T cell tolerance induction (GO:0002664)3.12378382
55response to type I interferon (GO:0034340)3.11675845
56cellular response to type I interferon (GO:0071357)3.10117118
57type I interferon signaling pathway (GO:0060337)3.10117118
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07973818
59response to interleukin-15 (GO:0070672)3.07871241
60detection of molecule of bacterial origin (GO:0032490)3.05560830
61defense response to protozoan (GO:0042832)3.03668056
62positive regulation of B cell differentiation (GO:0045579)3.01892116
63regulation of B cell differentiation (GO:0045577)3.01583089
64negative regulation of T cell mediated immunity (GO:0002710)2.99067773
65neutrophil activation (GO:0042119)2.98839404
66positive T cell selection (GO:0043368)2.97328556
67tolerance induction (GO:0002507)2.96743905
68regulation of mast cell activation involved in immune response (GO:0033006)2.93985211
69respiratory burst (GO:0045730)2.93532601
70regulation of tolerance induction (GO:0002643)2.90926115
71negative regulation of alpha-beta T cell activation (GO:0046636)2.88524513
72negative regulation of innate immune response (GO:0045824)2.86405128
73response to protozoan (GO:0001562)2.85012891
74response to host immune response (GO:0052572)2.84718152
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84718152
76myeloid cell activation involved in immune response (GO:0002275)2.84559134
77granulocyte activation (GO:0036230)2.82242123
78T cell migration (GO:0072678)2.80349945
79lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78086061
80regulation of T-helper 1 cell differentiation (GO:0045625)2.78037792
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77449040
82response to host (GO:0075136)2.77449040
83response to host defenses (GO:0052200)2.77449040
84positive regulation of Cdc42 GTPase activity (GO:0043089)2.76736388
85negative regulation of phagocytosis (GO:0050765)2.76720162
86leukocyte migration involved in inflammatory response (GO:0002523)2.76672889
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75782083
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73560169
89interferon-gamma-mediated signaling pathway (GO:0060333)2.73477428
90regulation of antigen processing and presentation (GO:0002577)2.72367571
91response to laminar fluid shear stress (GO:0034616)2.72366782
92negative regulation of interleukin-6 production (GO:0032715)2.70647127
93negative regulation of cytokine production involved in immune response (GO:0002719)2.70376836
94production of molecular mediator involved in inflammatory response (GO:0002532)2.68405226
95regulation of type 2 immune response (GO:0002828)2.65930050
96regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.65075415
97regulation of natural killer cell mediated immunity (GO:0002715)2.65075415
98signal complex assembly (GO:0007172)2.65031826
99negative regulation of toll-like receptor signaling pathway (GO:0034122)2.61501649
100negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.61212219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.45692364
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.36923791
3MYC_22102868_ChIP-Seq_BL_Human3.05768672
4KDM2B_26808549_Chip-Seq_SUP-B15_Human2.75887837
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.63486375
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.57956394
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55190526
8LXR_22292898_ChIP-Seq_THP-1_Human2.51428843
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.50578845
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49492498
11VDR_24763502_ChIP-Seq_THP-1_Human2.48402618
12TCF7_22412390_ChIP-Seq_EML_Mouse2.44324833
13KDM2B_26808549_Chip-Seq_DND41_Human2.41768309
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38747405
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.34336308
16MAF_26560356_Chip-Seq_TH1_Human2.32208532
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.32154803
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25294184
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20457610
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15517138
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11294665
22UTX_26944678_Chip-Seq_JUKART_Human2.10072652
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08010081
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07392475
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05217092
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.04944660
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01276436
28IRF8_21731497_ChIP-ChIP_J774_Mouse2.00580345
29MAF_26560356_Chip-Seq_TH2_Human1.98097872
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88744613
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.88088846
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83856602
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80973281
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77868260
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76364092
36SPI1_23127762_ChIP-Seq_K562_Human1.75335393
37RACK7_27058665_Chip-Seq_MCF-7_Human1.75003182
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70260399
39SCL_19346495_ChIP-Seq_HPC-7_Human1.70082062
40SPI1_23547873_ChIP-Seq_NB4_Human1.69077400
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67254340
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.65087114
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61000720
44RUNX_20019798_ChIP-Seq_JUKART_Human1.60730258
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57546485
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57372515
47MYB_26560356_Chip-Seq_TH1_Human1.56795801
48MYB_26560356_Chip-Seq_TH2_Human1.55248135
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53667335
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.52203987
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50011448
52KDM2B_26808549_Chip-Seq_K562_Human1.49922216
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47971138
54P68_20966046_ChIP-Seq_HELA_Human1.46168552
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.43195339
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.42877072
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41383023
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39670522
59BCOR_27268052_Chip-Seq_Bcells_Human1.37539838
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36630016
61BCL6_27268052_Chip-Seq_Bcells_Human1.36294823
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36274313
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34374127
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30991634
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29700807
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.28680831
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27756782
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27211773
69NCOR1_26117541_ChIP-Seq_K562_Human1.24744570
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20411184
71SMC4_20622854_ChIP-Seq_HELA_Human1.19124600
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17665009
73GATA1_19941826_ChIP-Seq_K562_Human1.17661581
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16795764
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.16066508
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15859863
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15481412
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14980904
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12106493
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11962326
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11464959
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.10634046
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06003072
84CREB1_26743006_Chip-Seq_LNCaP_Human1.05702157
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05299516
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04938794
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04631110
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04358648
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03597382
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03585272
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02402417
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.01971615
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01017100
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00152442
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97769338
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97584175
97GATA3_27048872_Chip-Seq_THYMUS_Human0.97129524
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96869993
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95148404
100E2F1_20622854_ChIP-Seq_HELA_Human0.94702887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.19321814
2MP0003303_peritoneal_inflammation3.45755920
3MP0003724_increased_susceptibility_to3.36316098
4MP0001835_abnormal_antigen_presentation3.09337956
5MP0001790_abnormal_immune_system2.71864823
6MP0005387_immune_system_phenotype2.71864823
7MP0001800_abnormal_humoral_immune2.69836833
8MP0002419_abnormal_innate_immunity2.69691889
9MP0000685_abnormal_immune_system2.66421250
10MP0005000_abnormal_immune_tolerance2.62512956
11MP0003763_abnormal_thymus_physiology2.58598818
12MP0005025_abnormal_response_to2.58141036
13MP0005671_abnormal_response_to2.57991865
14MP0005058_abnormal_lysosome_morphology2.43463039
15MP0003172_abnormal_lysosome_physiology2.42968398
16MP0003300_gastrointestinal_ulcer2.42635282
17MP0002723_abnormal_immune_serum2.33834639
18MP0002420_abnormal_adaptive_immunity2.29425844
19MP0002452_abnormal_antigen_presenting2.28671339
20MP0001819_abnormal_immune_cell2.27599663
21MP0009785_altered_susceptibility_to2.27440337
22MP0008260_abnormal_autophagy2.24311228
23MP0009278_abnormal_bone_marrow2.17548723
24MP0003191_abnormal_cellular_cholesterol2.11335291
25MP0004947_skin_inflammation2.09497776
26MP0006082_CNS_inflammation2.04119272
27MP0001533_abnormal_skeleton_physiology2.02620709
28MP0005451_abnormal_body_composition1.98867729
29MP0002405_respiratory_system_inflammati1.95781745
30MP0009333_abnormal_splenocyte_physiolog1.95179122
31MP0010155_abnormal_intestine_physiology1.90364014
32MP0002398_abnormal_bone_marrow1.86059894
33MP0002148_abnormal_hypersensitivity_rea1.84313936
34MP0000716_abnormal_immune_system1.79933754
35MP0005464_abnormal_platelet_physiology1.74236702
36MP0002396_abnormal_hematopoietic_system1.67563028
37MP0004510_myositis1.66803584
38MP0009840_abnormal_foam_cell1.58968323
39MP0001845_abnormal_inflammatory_respons1.57964447
40MP0001873_stomach_inflammation1.55089490
41MP0003705_abnormal_hypodermis_morpholog1.53595204
42MP0000858_altered_metastatic_potential1.53472582
43MP0002722_abnormal_immune_system1.52487538
44MP0000703_abnormal_thymus_morphology1.51098300
45MP0002429_abnormal_blood_cell1.47577384
46MP0004381_abnormal_hair_follicle1.47297004
47MP0002998_abnormal_bone_remodeling1.47292763
48MP0000689_abnormal_spleen_morphology1.46698419
49MP0003866_abnormal_defecation1.45046531
50MP0003828_pulmonary_edema1.40905618
51MP0002132_abnormal_respiratory_system1.36528011
52MP0008469_abnormal_protein_level1.33370913
53MP0000465_gastrointestinal_hemorrhage1.32258876
54MP0005076_abnormal_cell_differentiation1.31541366
55MP0001545_abnormal_hematopoietic_system1.27502974
56MP0005397_hematopoietic_system_phenotyp1.27502974
57MP0003183_abnormal_peptide_metabolism1.27185370
58MP0002933_joint_inflammation1.24911324
59MP0001849_ear_inflammation1.24515119
60MP0002138_abnormal_hepatobiliary_system1.24466500
61MP0001851_eye_inflammation1.22528261
62MP0005310_abnormal_salivary_gland1.17560858
63MP0001853_heart_inflammation1.15957447
64MP0003091_abnormal_cell_migration1.09246843
65MP0009764_decreased_sensitivity_to1.08364715
66MP0003453_abnormal_keratinocyte_physiol1.05098988
67MP0000490_abnormal_crypts_of0.97748787
68MP0005390_skeleton_phenotype0.96586372
69MP0001663_abnormal_digestive_system0.95274007
70MP0003075_altered_response_to0.95267750
71MP0004808_abnormal_hematopoietic_stem0.94319561
72MP0004858_abnormal_nervous_system0.90743827
73MP0004264_abnormal_extraembryonic_tissu0.90167701
74MP0005166_decreased_susceptibility_to0.89116638
75MP0002254_reproductive_system_inflammat0.88503444
76MP0005360_urolithiasis0.86946860
77MP0004883_abnormal_blood_vessel0.86896481
78MP0000604_amyloidosis0.84841912
79MP0003448_altered_tumor_morphology0.84309897
80MP0002166_altered_tumor_susceptibility0.82911226
81MP0008961_abnormal_basal_metabolism0.82845320
82MP0003690_abnormal_glial_cell0.82760855
83MP0003279_aneurysm0.80542060
84MP0005164_abnormal_response_to0.79667467
85MP0001348_abnormal_lacrimal_gland0.78663377
86MP0008004_abnormal_stomach_pH0.78439902
87MP0000678_abnormal_parathyroid_gland0.77630311
88MP0004185_abnormal_adipocyte_glucose0.76030436
89MP0003566_abnormal_cell_adhesion0.74545453
90MP0003795_abnormal_bone_structure0.74442105
91MP0004130_abnormal_muscle_cell0.71401291
92MP0000249_abnormal_blood_vessel0.71278950
93MP0001958_emphysema0.71119038
94MP0005666_abnormal_adipose_tissue0.68001810
95MP0000343_altered_response_to0.66229972
96MP0005023_abnormal_wound_healing0.65519814
97MP0000767_abnormal_smooth_muscle0.65333837
98MP0008874_decreased_physiological_sensi0.62736397
99MP0005409_darkened_coat_color0.62347200
100MP0000609_abnormal_liver_physiology0.61017300

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.75028555
2Recurrent bacterial skin infections (HP:0005406)4.57671697
3Recurrent abscess formation (HP:0002722)4.54674394
4Abnormality of macrophages (HP:0004311)4.39918505
5Myositis (HP:0100614)4.30349040
6Orchitis (HP:0100796)3.85328731
7Recurrent gram-negative bacterial infections (HP:0005420)3.61154360
8Increased IgE level (HP:0003212)3.60599746
9Recurrent fungal infections (HP:0002841)3.52035569
10Mediastinal lymphadenopathy (HP:0100721)3.46163489
11Elevated erythrocyte sedimentation rate (HP:0003565)3.40925511
12Obstructive lung disease (HP:0006536)3.39726492
13Chronic obstructive pulmonary disease (HP:0006510)3.39726492
14Optic neuritis (HP:0100653)3.39465362
15Retrobulbar optic neuritis (HP:0100654)3.39465362
16Meningitis (HP:0001287)3.38093106
17Gastrointestinal infarctions (HP:0005244)3.31530713
18Cellulitis (HP:0100658)3.23861000
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.21195517
20Colitis (HP:0002583)3.16619327
21Gingivitis (HP:0000230)3.13107002
22Recurrent skin infections (HP:0001581)3.08690773
23Gastrointestinal inflammation (HP:0004386)3.03266512
24Spontaneous hematomas (HP:0007420)3.01083103
25Stomatitis (HP:0010280)3.00949662
26Pustule (HP:0200039)3.00875335
27Inflammation of the large intestine (HP:0002037)2.94699518
28Prolonged bleeding time (HP:0003010)2.91536222
29Vasculitis (HP:0002633)2.90599295
30Recurrent cutaneous fungal infections (HP:0011370)2.87677206
31Chronic mucocutaneous candidiasis (HP:0002728)2.87677206
32Recurrent viral infections (HP:0004429)2.87518517
33Panhypogammaglobulinemia (HP:0003139)2.85778285
34Encephalitis (HP:0002383)2.72979659
35Dysostosis multiplex (HP:0000943)2.68136273
36Chest pain (HP:0100749)2.58261570
37Gastrointestinal stroma tumor (HP:0100723)2.51227866
38Keratoconjunctivitis sicca (HP:0001097)2.48430880
39Epistaxis (HP:0000421)2.45592648
40Urticaria (HP:0001025)2.42946027
41Agammaglobulinemia (HP:0004432)2.41531173
42Pulmonary infiltrates (HP:0002113)2.41037901
43Hypochromic anemia (HP:0001931)2.39304217
44Hemoptysis (HP:0002105)2.37012763
45Obstructive sleep apnea (HP:0002870)2.32745132
46Petechiae (HP:0000967)2.32052931
47Lymphopenia (HP:0001888)2.31609366
48Increased serum ferritin (HP:0003281)2.30867082
49Systemic lupus erythematosus (HP:0002725)2.29680488
50Emphysema (HP:0002097)2.29581928
51Purpura (HP:0000979)2.28834059
52Thin bony cortex (HP:0002753)2.23620335
53Osteomyelitis (HP:0002754)2.21631109
54Malnutrition (HP:0004395)2.20205130
55Slow saccadic eye movements (HP:0000514)2.18167696
56Keratoconjunctivitis (HP:0001096)2.18142783
57Abnormality of the fingertips (HP:0001211)2.17595292
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.14558266
59Granulocytopenia (HP:0001913)2.13820585
60Broad face (HP:0000283)2.11843076
61Hemorrhage of the eye (HP:0011885)2.10798057
62Premature loss of primary teeth (HP:0006323)2.08988885
63Loss of speech (HP:0002371)2.08594697
64Increased cerebral lipofuscin (HP:0011813)2.08370040
65Urinary glycosaminoglycan excretion (HP:0003541)2.07629610
66Mucopolysacchariduria (HP:0008155)2.07629610
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07299784
68Abnormality of polysaccharide metabolism (HP:0011012)2.07299784
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07299784
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06822138
71Restrictive lung disease (HP:0002091)2.04985313
72Amyloidosis (HP:0011034)2.04843181
73T lymphocytopenia (HP:0005403)2.04723210
74Gingival bleeding (HP:0000225)2.01401438
75Leukocytosis (HP:0001974)1.98885930
76Arterial thrombosis (HP:0004420)1.97729674
77Hepatosplenomegaly (HP:0001433)1.97721423
78Cerebral aneurysm (HP:0004944)1.97409556
79Peritonitis (HP:0002586)1.97216641
80Abnormality of glycolipid metabolism (HP:0010969)1.96992992
81Abnormality of liposaccharide metabolism (HP:0010968)1.96992992
82Abnormality of glycosphingolipid metabolism (HP:0004343)1.96992992
83Metaphyseal cupping (HP:0003021)1.96296133
84Polygenic inheritance (HP:0010982)1.96277639
85Viral hepatitis (HP:0006562)1.96025242
86Papilloma (HP:0012740)1.95829115
87Verrucae (HP:0200043)1.95829115
88Easy fatigability (HP:0003388)1.95153351
89Pulmonary embolism (HP:0002204)1.94080311
90Episodic fever (HP:0001954)1.93844197
91Sepsis (HP:0100806)1.92623184
92Abnormality of the peritoneum (HP:0002585)1.90395738
93Segmental peripheral demyelination/remyelination (HP:0003481)1.89431616
94Hypergammaglobulinemia (HP:0010702)1.88648400
95Abnormality of iron homeostasis (HP:0011031)1.88451567
96Abnormality of the pleura (HP:0002103)1.87582648
97Increased IgM level (HP:0003496)1.87309949
98Interstitial pulmonary disease (HP:0006530)1.86279169
99Hypertriglyceridemia (HP:0002155)1.86202733
100Skin ulcer (HP:0200042)1.85374746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.92511399
2ERN13.53932655
3RIPK43.36140105
4PRPF4B3.23932094
5TRIB33.05302943
6MAP2K32.64600781
7SIK12.49566970
8TYK22.36069939
9BLK2.33054320
10IRAK42.26416698
11TNK22.09124653
12SMG11.91202231
13SIK31.88871467
14ZAP701.86571115
15MAP3K131.80996394
16GRK61.79662055
17CSK1.79239947
18MAP3K31.78197866
19MAP3K141.63845907
20FES1.61375539
21EPHB11.61362801
22SIK21.60380589
23MAP3K111.56508339
24TBK11.50779799
25BTK1.49533548
26TAOK11.49239183
27JAK31.43353387
28MARK21.40483259
29MAP3K101.39085562
30FGFR41.37257788
31CDC42BPA1.32496057
32HCK1.25828618
33ICK1.24744818
34IKBKE1.24276197
35MAP3K11.23461975
36RIPK11.20289271
37IRAK31.20256671
38PRKD21.15995193
39CDK121.15346386
40FGR1.14172587
41MARK31.11073892
42SYK1.10716582
43TAOK21.10570377
44PTK61.04049226
45MAP3K71.02648776
46CSF1R1.01246391
47JAK11.00473043
48TXK0.99856327
49MAP3K60.97072542
50HIPK20.91675047
51IKBKB0.88510893
52LYN0.86868940
53LCK0.86625610
54ITK0.85223469
55JAK20.82484398
56PDPK10.79060476
57KSR20.78963317
58IRAK20.78028038
59MAPK70.76277673
60NME20.76056942
61MAPK120.74337037
62PKN20.74223176
63PDK10.73790341
64RPS6KL10.71939683
65RPS6KC10.71939683
66MAP2K60.70115503
67KIT0.68421603
68TTN0.66317459
69MATK0.65554437
70DYRK1B0.64824137
71EEF2K0.63850944
72IRAK10.62535075
73FGFR30.61240095
74CDK40.60801226
75TGFBR20.59980396
76RPS6KA20.58478773
77BMX0.56874603
78RPS6KA60.56342634
79CAMKK10.55646266
80TESK20.55572745
81LRRK20.53951386
82TYRO30.51959609
83STK100.51573180
84MAP2K20.51191856
85MAPK110.47052483
86CHUK0.45791012
87RET0.45164898
88FYN0.43898958
89MTOR0.42867451
90YES10.38650376
91MAPKAPK20.38424297
92PDGFRB0.37208804
93MAP3K80.34053186
94STK380.33201554
95MAP3K20.33009957
96PAK40.32847083
97MAPK40.32394388
98PDGFRA0.31962497
99PRKCQ0.31401745
100TEC0.30837716

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.59936395
2Other glycan degradation_Homo sapiens_hsa005112.56306873
3Leishmaniasis_Homo sapiens_hsa051402.46738631
4B cell receptor signaling pathway_Homo sapiens_hsa046622.34748927
5Staphylococcus aureus infection_Homo sapiens_hsa051502.19788937
6Allograft rejection_Homo sapiens_hsa053301.97253105
7Acute myeloid leukemia_Homo sapiens_hsa052211.97125512
8Primary immunodeficiency_Homo sapiens_hsa053401.96583787
9Graft-versus-host disease_Homo sapiens_hsa053321.92232311
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83963662
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82723185
12Autoimmune thyroid disease_Homo sapiens_hsa053201.82672847
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.72356275
14Tuberculosis_Homo sapiens_hsa051521.70523459
15T cell receptor signaling pathway_Homo sapiens_hsa046601.69405272
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68662358
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62518264
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56528464
19Toxoplasmosis_Homo sapiens_hsa051451.53406088
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51896598
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49670565
22Influenza A_Homo sapiens_hsa051641.44559755
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42666668
24Measles_Homo sapiens_hsa051621.42661699
25TNF signaling pathway_Homo sapiens_hsa046681.38719091
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.38248905
27Chemokine signaling pathway_Homo sapiens_hsa040621.37733013
28Malaria_Homo sapiens_hsa051441.37456569
29Non-small cell lung cancer_Homo sapiens_hsa052231.35797146
30Notch signaling pathway_Homo sapiens_hsa043301.35738871
31Hematopoietic cell lineage_Homo sapiens_hsa046401.35098288
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35010093
33Chronic myeloid leukemia_Homo sapiens_hsa052201.34319465
34Antigen processing and presentation_Homo sapiens_hsa046121.33370551
35Viral myocarditis_Homo sapiens_hsa054161.32991283
36Herpes simplex infection_Homo sapiens_hsa051681.32868779
37Type I diabetes mellitus_Homo sapiens_hsa049401.28714289
38VEGF signaling pathway_Homo sapiens_hsa043701.28321777
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27575666
40Hepatitis B_Homo sapiens_hsa051611.20185487
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.17966106
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.13626190
43Hepatitis C_Homo sapiens_hsa051601.12749880
44Asthma_Homo sapiens_hsa053101.10778952
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.10305261
46Pancreatic cancer_Homo sapiens_hsa052121.07526658
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.04009891
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03731261
49Pertussis_Homo sapiens_hsa051331.03181910
50Platelet activation_Homo sapiens_hsa046111.01971944
51Apoptosis_Homo sapiens_hsa042100.97200479
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.95037581
53Phagosome_Homo sapiens_hsa041450.93699816
54Lysosome_Homo sapiens_hsa041420.92383861
55GnRH signaling pathway_Homo sapiens_hsa049120.91430780
56Legionellosis_Homo sapiens_hsa051340.90251507
57HTLV-I infection_Homo sapiens_hsa051660.89038272
58Shigellosis_Homo sapiens_hsa051310.86890284
59Prolactin signaling pathway_Homo sapiens_hsa049170.86410508
60African trypanosomiasis_Homo sapiens_hsa051430.85156972
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.84813877
62Viral carcinogenesis_Homo sapiens_hsa052030.84042298
63Choline metabolism in cancer_Homo sapiens_hsa052310.83154931
64Renal cell carcinoma_Homo sapiens_hsa052110.83119721
65Salmonella infection_Homo sapiens_hsa051320.79221540
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78079108
67mTOR signaling pathway_Homo sapiens_hsa041500.77839715
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77466816
69Rheumatoid arthritis_Homo sapiens_hsa053230.75200063
70Endocytosis_Homo sapiens_hsa041440.74135778
71Epstein-Barr virus infection_Homo sapiens_hsa051690.73935998
72Endometrial cancer_Homo sapiens_hsa052130.73514210
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71843040
74Bladder cancer_Homo sapiens_hsa052190.71496577
75Insulin resistance_Homo sapiens_hsa049310.71467378
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69714739
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.67873830
78Amoebiasis_Homo sapiens_hsa051460.67322797
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67236141
80FoxO signaling pathway_Homo sapiens_hsa040680.65638025
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.62936896
82Inositol phosphate metabolism_Homo sapiens_hsa005620.59707614
83Estrogen signaling pathway_Homo sapiens_hsa049150.58648969
84Colorectal cancer_Homo sapiens_hsa052100.58522459
85MAPK signaling pathway_Homo sapiens_hsa040100.58481884
86Insulin signaling pathway_Homo sapiens_hsa049100.57155461
87ErbB signaling pathway_Homo sapiens_hsa040120.55876422
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55508804
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55258005
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54391250
91Prostate cancer_Homo sapiens_hsa052150.52913998
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52286568
93Prion diseases_Homo sapiens_hsa050200.51920631
94Glioma_Homo sapiens_hsa052140.51436726
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51280867
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49766260
97Small cell lung cancer_Homo sapiens_hsa052220.48276627
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47941918
99Rap1 signaling pathway_Homo sapiens_hsa040150.47901399
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47887208

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