ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.27326826
2	piRNA metabolic process (GO:0034587)	5.11431656
3	behavioral response to nicotine (GO:0035095)	4.59423599
4	platelet dense granule organization (GO:0060155)	3.99043672
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.85890664
6	male meiosis I (GO:0007141)	3.79618637
7	regulation of cilium movement (GO:0003352)	3.79550549
8	DNA methylation involved in gamete generation (GO:0043046)	3.79280475
9	fucose catabolic process (GO:0019317)	3.78057760
10	L-fucose metabolic process (GO:0042354)	3.78057760
11	L-fucose catabolic process (GO:0042355)	3.78057760
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.67462071
13	detection of light stimulus involved in visual perception (GO:0050908)	3.67462071
14	synapsis (GO:0007129)	3.63420207
15	regulation of meiosis I (GO:0060631)	3.59492407
16	epithelial cilium movement (GO:0003351)	3.56577943
17	DNA deamination (GO:0045006)	3.52944855
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.50905313
19	protein K11-linked deubiquitination (GO:0035871)	3.50193562
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.47847984
21	pyrimidine nucleobase catabolic process (GO:0006208)	3.47201363
22	neural tube formation (GO:0001841)	3.36116250
23	male meiosis (GO:0007140)	3.32260578
24	protein complex biogenesis (GO:0070271)	3.27931475
25	regulation of glucokinase activity (GO:0033131)	3.23620756
26	regulation of hexokinase activity (GO:1903299)	3.23620756
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.16397034
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.16397034
29	NADH dehydrogenase complex assembly (GO:0010257)	3.16397034
30	tryptophan catabolic process (GO:0006569)	3.14550290
31	indole-containing compound catabolic process (GO:0042436)	3.14550290
32	indolalkylamine catabolic process (GO:0046218)	3.14550290
33	nucleobase catabolic process (GO:0046113)	3.14082636
34	indolalkylamine metabolic process (GO:0006586)	3.12897832
35	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.11035312
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.09383948
37	negative regulation of telomere maintenance (GO:0032205)	3.02233386
38	ketone body metabolic process (GO:1902224)	3.00596500
39	reciprocal DNA recombination (GO:0035825)	2.97031743
40	reciprocal meiotic recombination (GO:0007131)	2.97031743
41	cellular ketone body metabolic process (GO:0046950)	2.93867198
42	cilium morphogenesis (GO:0060271)	2.92595489
43	protein localization to cilium (GO:0061512)	2.91691324
44	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.89757562
45	intraciliary transport (GO:0042073)	2.89558337
46	kynurenine metabolic process (GO:0070189)	2.89444613
47	axoneme assembly (GO:0035082)	2.89283581
48	meiosis I (GO:0007127)	2.89012591
49	sperm motility (GO:0030317)	2.87318286
50	dopamine transport (GO:0015872)	2.86462840
51	cilium movement (GO:0003341)	2.86318678
52	multicellular organism reproduction (GO:0032504)	2.85740032
53	cornea development in camera-type eye (GO:0061303)	2.84386038
54	respiratory chain complex IV assembly (GO:0008535)	2.84200679
55	nonmotile primary cilium assembly (GO:0035058)	2.82785788
56	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.81331040
57	positive regulation of meiosis (GO:0045836)	2.80433307
58	protein polyglutamylation (GO:0018095)	2.80128949
59	retinal cone cell development (GO:0046549)	2.80050041
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.79458596
61	negative regulation of mast cell activation (GO:0033004)	2.78579144
62	replication fork processing (GO:0031297)	2.76981550
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75425853
64	cilium organization (GO:0044782)	2.73676320
65	behavioral response to ethanol (GO:0048149)	2.73353886
66	cilium or flagellum-dependent cell motility (GO:0001539)	2.70442608
67	cytochrome complex assembly (GO:0017004)	2.68287702
68	cilium assembly (GO:0042384)	2.67735098
69	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.67459908
70	ubiquinone biosynthetic process (GO:0006744)	2.66582664
71	recombinational repair (GO:0000725)	2.66244105
72	tryptophan metabolic process (GO:0006568)	2.65499149
73	mannosylation (GO:0097502)	2.64938257
74	double-strand break repair via homologous recombination (GO:0000724)	2.63611344
75	positive regulation of fatty acid transport (GO:2000193)	2.63235571
76	regulation of action potential (GO:0098900)	2.61675936
77	protein-cofactor linkage (GO:0018065)	2.61432201
78	positive regulation of meiotic cell cycle (GO:0051446)	2.60668379
79	nephron epithelium morphogenesis (GO:0072088)	2.59080248
80	nephron tubule morphogenesis (GO:0072078)	2.59080248
81	photoreceptor cell development (GO:0042461)	2.57693314
82	transmission of nerve impulse (GO:0019226)	2.55884501
83	rhodopsin mediated signaling pathway (GO:0016056)	2.55571858
84	chromosome organization involved in meiosis (GO:0070192)	2.55407665
85	seminiferous tubule development (GO:0072520)	2.52284801
86	ubiquinone metabolic process (GO:0006743)	2.52018000
87	regulation of microtubule-based movement (GO:0060632)	2.51286718
88	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.50916507
89	proline transport (GO:0015824)	2.48325033
90	cell proliferation in forebrain (GO:0021846)	2.48135562
91	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.47761178
92	photoreceptor cell maintenance (GO:0045494)	2.47491569
93	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.46791882
94	synaptic transmission, cholinergic (GO:0007271)	2.45382062
95	centriole replication (GO:0007099)	2.45093247
96	C4-dicarboxylate transport (GO:0015740)	2.44527714
97	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.43061632
98	embryonic epithelial tube formation (GO:0001838)	2.42103968
99	resolution of meiotic recombination intermediates (GO:0000712)	2.41664282
100	meiotic chromosome segregation (GO:0045132)	2.41485683

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.40224471
2	VDR_22108803_ChIP-Seq_LS180_Human	3.00295648
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.69902801
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61192154
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.60727895
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.52103991
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.47422535
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.44273841
9	FUS_26573619_Chip-Seq_HEK293_Human	2.28682809
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.19318916
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.16633451
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.15899946
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15258329
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12250402
15	P300_19829295_ChIP-Seq_ESCs_Human	2.08093680
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06945242
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.04822188
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02078512
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.97597664
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.95988123
21	EWS_26573619_Chip-Seq_HEK293_Human	1.88026405
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.85999426
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82486226
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.74439300
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.72967346
26	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.72774771
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70270936
28	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68231942
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.66414346
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65180304
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.64802632
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57410639
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.56432025
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56286577
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55398242
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.54191101
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53432116
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.53351295
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53351295
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48077515
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47824349
42	STAT3_23295773_ChIP-Seq_U87_Human	1.46479399
43	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45546090
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44523715
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44523715
46	AR_25329375_ChIP-Seq_VCAP_Human	1.44113744
47	TCF4_23295773_ChIP-Seq_U87_Human	1.42774223
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41033420
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40286679
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40286679
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36721603
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33644036
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33644036
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32852089
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32751746
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32598255
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31904586
58	NCOR_22424771_ChIP-Seq_293T_Human	1.31398041
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29537856
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29358387
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.28165455
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27381608
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26274360
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.26141751
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26097961
66	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25735719
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25357936
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24253017
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23492465
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23275515
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23004629
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22692553
73	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22103846
74	VDR_23849224_ChIP-Seq_CD4+_Human	1.20309213
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20122045
76	AR_20517297_ChIP-Seq_VCAP_Human	1.20057035
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.18882405
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17615617
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15271893
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15262269
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13874534
82	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11726097
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11212715
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09619723
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08364807
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02988143
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01503855
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99681902
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99557504
90	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99454145
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99353637
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98917062
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98243926
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97293412
95	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95996620
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95952102
97	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95438344
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93937869
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93811455
100	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.92390014

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.99985753
2	MP0003195_calcinosis	2.94722832
3	MP0002102_abnormal_ear_morphology	2.76595459
4	MP0000569_abnormal_digit_pigmentation	2.71602063
5	MP0000372_irregular_coat_pigmentation	2.54883383
6	MP0005551_abnormal_eye_electrophysiolog	2.51752449
7	MP0001986_abnormal_taste_sensitivity	2.46335840
8	MP0002876_abnormal_thyroid_physiology	2.28460208
9	MP0003880_abnormal_central_pattern	2.26089840
10	MP0003136_yellow_coat_color	2.17989923
11	MP0005645_abnormal_hypothalamus_physiol	2.04859646
12	MP0000015_abnormal_ear_pigmentation	2.04338258
13	MP0004133_heterotaxia	2.03252237
14	MP0006072_abnormal_retinal_apoptosis	1.98862044
15	MP0002638_abnormal_pupillary_reflex	1.92496920
16	MP0005646_abnormal_pituitary_gland	1.89322894
17	MP0001501_abnormal_sleep_pattern	1.88377224
18	MP0009046_muscle_twitch	1.88201181
19	MP0005253_abnormal_eye_physiology	1.87664401
20	MP0008872_abnormal_physiological_respon	1.79939584
21	MP0009745_abnormal_behavioral_response	1.75175456
22	MP0006292_abnormal_olfactory_placode	1.72527343
23	MP0005174_abnormal_tail_pigmentation	1.71044088
24	MP0008995_early_reproductive_senescence	1.70348604
25	MP0006276_abnormal_autonomic_nervous	1.68299997
26	MP0004885_abnormal_endolymph	1.66842476
27	MP0003787_abnormal_imprinting	1.60620812
28	MP0002653_abnormal_ependyma_morphology	1.60120891
29	MP0004142_abnormal_muscle_tone	1.58915488
30	MP0002163_abnormal_gland_morphology	1.54631455
31	MP0002272_abnormal_nervous_system	1.50368501
32	MP0005075_abnormal_melanosome_morpholog	1.48409806
33	MP0005410_abnormal_fertilization	1.47928161
34	MP0001529_abnormal_vocalization	1.47121914
35	MP0002909_abnormal_adrenal_gland	1.44760526
36	MP0002837_dystrophic_cardiac_calcinosis	1.44506693
37	MP0000631_abnormal_neuroendocrine_gland	1.43829570
38	MP0002938_white_spotting	1.43673658
39	MP0003646_muscle_fatigue	1.42676290
40	MP0002095_abnormal_skin_pigmentation	1.39654259
41	MP0005379_endocrine/exocrine_gland_phen	1.38486033
42	MP0002160_abnormal_reproductive_system	1.37542394
43	MP0000427_abnormal_hair_cycle	1.34166552
44	MP0001968_abnormal_touch/_nociception	1.33721541
45	MP0001486_abnormal_startle_reflex	1.31574919
46	MP0001984_abnormal_olfaction	1.28478533
47	MP0003011_delayed_dark_adaptation	1.27341209
48	MP0004147_increased_porphyrin_level	1.25904692
49	MP0008875_abnormal_xenobiotic_pharmacok	1.24550767
50	MP0001485_abnormal_pinna_reflex	1.23982315
51	MP0003698_abnormal_male_reproductive	1.22524044
52	MP0005084_abnormal_gallbladder_morpholo	1.20307420
53	MP0005389_reproductive_system_phenotype	1.20081407
54	MP0002928_abnormal_bile_duct	1.20056063
55	MP0008058_abnormal_DNA_repair	1.18468612
56	MP0001929_abnormal_gametogenesis	1.16767142
57	MP0002210_abnormal_sex_determination	1.16134144
58	MP0005423_abnormal_somatic_nervous	1.15293586
59	MP0002572_abnormal_emotion/affect_behav	1.14935611
60	MP0002064_seizures	1.14706816
61	MP0003950_abnormal_plasma_membrane	1.14323532
62	MP0001324_abnormal_eye_pigmentation	1.11936880
63	MP0004043_abnormal_pH_regulation	1.11134254
64	MP0003718_maternal_effect	1.07691398
65	MP0004924_abnormal_behavior	1.07469284
66	MP0005386_behavior/neurological_phenoty	1.07469284
67	MP0002735_abnormal_chemical_nociception	1.05140926
68	MP0002557_abnormal_social/conspecific_i	1.03908598
69	MP0001764_abnormal_homeostasis	1.02709053
70	MP0005167_abnormal_blood-brain_barrier	1.02551128
71	MP0002277_abnormal_respiratory_mucosa	1.02078461
72	MP0001919_abnormal_reproductive_system	1.01992466
73	MP0000013_abnormal_adipose_tissue	0.99835857
74	MP0000653_abnormal_sex_gland	0.99514003
75	MP0000383_abnormal_hair_follicle	0.99122735
76	MP0008789_abnormal_olfactory_epithelium	0.98938984
77	MP0004215_abnormal_myocardial_fiber	0.98572947
78	MP0005195_abnormal_posterior_eye	0.98236132
79	MP0002234_abnormal_pharynx_morphology	0.96566059
80	MP0001145_abnormal_male_reproductive	0.92501730
81	MP0004742_abnormal_vestibular_system	0.91934695
82	MP0002751_abnormal_autonomic_nervous	0.91816825
83	MP0002063_abnormal_learning/memory/cond	0.90965511
84	MP0003635_abnormal_synaptic_transmissio	0.90623010
85	MP0001905_abnormal_dopamine_level	0.90481512
86	MP0010386_abnormal_urinary_bladder	0.89534649
87	MP0002733_abnormal_thermal_nociception	0.88929275
88	MP0001502_abnormal_circadian_rhythm	0.88117030
89	MP0000647_abnormal_sebaceous_gland	0.86472381
90	MP0002067_abnormal_sensory_capabilities	0.86281169
91	MP0001970_abnormal_pain_threshold	0.86242989
92	MP0002736_abnormal_nociception_after	0.85418050
93	MP0002229_neurodegeneration	0.85200216
94	MP0002752_abnormal_somatic_nervous	0.82489779
95	MP0005332_abnormal_amino_acid	0.80596042
96	MP0003121_genomic_imprinting	0.80423736
97	MP0004085_abnormal_heartbeat	0.78754524
98	MP0002822_catalepsy	0.77767817
99	MP0002184_abnormal_innervation	0.76024559
100	MP0010329_abnormal_lipoprotein_level	0.75487151

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.52321902
2	Pancreatic fibrosis (HP:0100732)	4.14388364
3	Nephronophthisis (HP:0000090)	3.95111568
4	True hermaphroditism (HP:0010459)	3.90425500
5	Molar tooth sign on MRI (HP:0002419)	3.78599090
6	Abnormality of midbrain morphology (HP:0002418)	3.78599090
7	Abnormality of the renal medulla (HP:0100957)	3.47672620
8	Abnormality of the renal cortex (HP:0011035)	3.32759483
9	Congenital stationary night blindness (HP:0007642)	3.29914290
10	Medial flaring of the eyebrow (HP:0010747)	3.14858624
11	Type II lissencephaly (HP:0007260)	3.01015934
12	Chronic hepatic failure (HP:0100626)	2.96939547
13	Abnormal rod and cone electroretinograms (HP:0008323)	2.87543346
14	Pendular nystagmus (HP:0012043)	2.79127672
15	Tubular atrophy (HP:0000092)	2.75548485
16	Cystic liver disease (HP:0006706)	2.74931946
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.70456587
18	Absent/shortened dynein arms (HP:0200106)	2.70456587
19	Abnormal drinking behavior (HP:0030082)	2.67775451
20	Polydipsia (HP:0001959)	2.67775451
21	Renal cortical cysts (HP:0000803)	2.64411157
22	Sclerocornea (HP:0000647)	2.60585352
23	Intestinal atresia (HP:0011100)	2.57418207
24	Inability to walk (HP:0002540)	2.56044916
25	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.55893000
26	Gait imbalance (HP:0002141)	2.55763850
27	Nephrogenic diabetes insipidus (HP:0009806)	2.53748440
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.51031268
29	Congenital primary aphakia (HP:0007707)	2.50043124
30	Tubulointerstitial nephritis (HP:0001970)	2.49771653
31	Lissencephaly (HP:0001339)	2.46775046
32	Attenuation of retinal blood vessels (HP:0007843)	2.40787391
33	Acute necrotizing encephalopathy (HP:0006965)	2.40686876
34	Gaze-evoked nystagmus (HP:0000640)	2.39714208
35	Progressive inability to walk (HP:0002505)	2.37515142
36	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36633736
37	Postaxial foot polydactyly (HP:0001830)	2.31645729
38	Anencephaly (HP:0002323)	2.29784811
39	Bile duct proliferation (HP:0001408)	2.28527593
40	Abnormal biliary tract physiology (HP:0012439)	2.28527593
41	Methylmalonic acidemia (HP:0002912)	2.28424763
42	Abolished electroretinogram (ERG) (HP:0000550)	2.25436443
43	Broad-based gait (HP:0002136)	2.25243493
44	Short tibia (HP:0005736)	2.25012711
45	Hyperventilation (HP:0002883)	2.23130457
46	Abnormal respiratory motile cilium morphology (HP:0005938)	2.22756990
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.22756990
48	Progressive macrocephaly (HP:0004481)	2.21631553
49	Cerebellar dysplasia (HP:0007033)	2.20265005
50	Volvulus (HP:0002580)	2.18858685
51	Acute encephalopathy (HP:0006846)	2.14842555
52	Congenital hepatic fibrosis (HP:0002612)	2.14290408
53	Bony spicule pigmentary retinopathy (HP:0007737)	2.13717709
54	Polyuria (HP:0000103)	2.13423382
55	Hypothermia (HP:0002045)	2.12836285
56	Supernumerary spleens (HP:0009799)	2.09573366
57	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.08515288
58	Hypoplasia of the fovea (HP:0007750)	2.08515288
59	Abnormal ciliary motility (HP:0012262)	2.08475088
60	Furrowed tongue (HP:0000221)	2.07819932
61	Constricted visual fields (HP:0001133)	2.05518102
62	Mitochondrial inheritance (HP:0001427)	2.05150874
63	Stomach cancer (HP:0012126)	2.04997732
64	Abnormality of the fovea (HP:0000493)	2.04012558
65	Keratoconus (HP:0000563)	2.02888141
66	Increased corneal curvature (HP:0100692)	2.02888141
67	Abnormality of the ileum (HP:0001549)	2.00626518
68	Decreased central vision (HP:0007663)	2.00489343
69	Tubulointerstitial abnormality (HP:0001969)	1.97565769
70	Hyperglycinemia (HP:0002154)	1.95275014
71	Occipital encephalocele (HP:0002085)	1.94163186
72	Optic disc pallor (HP:0000543)	1.92874368
73	Genital tract atresia (HP:0001827)	1.92189175
74	Progressive cerebellar ataxia (HP:0002073)	1.92054664
75	Abnormal mitochondria in muscle tissue (HP:0008316)	1.90400775
76	Male pseudohermaphroditism (HP:0000037)	1.89503198
77	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89457183
78	Disproportionate short-trunk short stature (HP:0003521)	1.88783575
79	Increased CSF lactate (HP:0002490)	1.88290412
80	Methylmalonic aciduria (HP:0012120)	1.88125943
81	Meckel diverticulum (HP:0002245)	1.87554471
82	Postaxial hand polydactyly (HP:0001162)	1.86858161
83	Hyperglycinuria (HP:0003108)	1.86432124
84	3-Methylglutaconic aciduria (HP:0003535)	1.85053159
85	Severe muscular hypotonia (HP:0006829)	1.84636000
86	Thyroid-stimulating hormone excess (HP:0002925)	1.84359314
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.82708209
88	Large for gestational age (HP:0001520)	1.82418260
89	Abnormality of macular pigmentation (HP:0008002)	1.80838578
90	Pachygyria (HP:0001302)	1.79761687
91	Preaxial hand polydactyly (HP:0001177)	1.79630463
92	Vaginal atresia (HP:0000148)	1.79468097
93	Concave nail (HP:0001598)	1.78402111
94	Astigmatism (HP:0000483)	1.78146387
95	Abnormality of the pons (HP:0007361)	1.76943413
96	Albinism (HP:0001022)	1.76284827
97	Absent speech (HP:0001344)	1.75736051
98	Abnormality of vitamin B metabolism (HP:0004340)	1.75540557
99	Poor coordination (HP:0002370)	1.74247233
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73197329

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.65090714
2	ADRBK2	2.95900303
3	MAP4K2	2.74408481
4	ZAK	2.65680804
5	PINK1	2.58539365
6	TAOK3	2.47009836
7	WNK3	2.41146421
8	MAPK13	2.26298615
9	BMPR1B	2.15435312
10	WNK4	2.13556985
11	GRK1	1.97868827
12	CASK	1.96657873
13	TRIM28	1.90682219
14	INSRR	1.90415943
15	STK16	1.89223722
16	NUAK1	1.87216007
17	STK39	1.62467256
18	TLK1	1.61347645
19	ACVR1B	1.57937367
20	PNCK	1.51331914
21	OXSR1	1.40853862
22	PLK2	1.39282478
23	MAP3K4	1.38701097
24	NTRK3	1.36963746
25	BCR	1.36561867
26	CAMKK2	1.35401521
27	MARK1	1.34871427
28	PAK3	1.31570153
29	STK38L	1.24441745
30	PLK4	1.17751660
31	CSNK1G1	1.16409158
32	CSNK1G2	1.15245129
33	EIF2AK3	1.14988877
34	CSNK1G3	1.14635509
35	MAPKAPK3	1.14623865
36	PTK2B	1.13771026
37	TNIK	1.13336457
38	SRPK1	1.12615507
39	DYRK2	1.12411282
40	MAP2K7	1.09738468
41	TXK	1.05768701
42	ERBB3	1.03876745
43	MKNK2	1.03403204
44	ADRBK1	0.99339930
45	PHKG2	0.93299633
46	PHKG1	0.93299633
47	VRK1	0.91347440
48	PRKCE	0.91213702
49	CSNK1A1L	0.88966529
50	DAPK2	0.86995040
51	PLK3	0.86291744
52	BRSK2	0.83224549
53	EPHA4	0.80848177
54	PRKCG	0.78326752
55	PRKCI	0.72842497
56	MUSK	0.71087786
57	SIK2	0.70265964
58	SIK3	0.66740962
59	MARK3	0.66076704
60	MINK1	0.63393467
61	BCKDK	0.62616903
62	CCNB1	0.62121419
63	WEE1	0.62015581
64	TNK2	0.60256922
65	IRAK1	0.57026841
66	MST4	0.56880918
67	MKNK1	0.54541901
68	PRKCQ	0.53641689
69	FER	0.52992402
70	KSR1	0.52434483
71	CSNK1A1	0.51930708
72	PRKCZ	0.50381870
73	NEK1	0.49616803
74	NEK2	0.49387932
75	CSNK1D	0.46992632
76	DYRK3	0.46319971
77	IKBKB	0.46129040
78	TEC	0.45522455
79	CAMK2A	0.43599354
80	PRKACA	0.43498590
81	PLK1	0.41972114
82	STK3	0.40727955
83	SGK2	0.40592017
84	CHUK	0.40186233
85	PRKG1	0.39702809
86	PIK3CA	0.39297681
87	GRK5	0.38933194
88	KIT	0.38717193
89	ATM	0.38286659
90	FGFR2	0.38156610
91	MAP2K1	0.38127398
92	DYRK1A	0.37153900
93	CAMK1	0.36043814
94	PRKAA1	0.33776760
95	IGF1R	0.33150846
96	PRKACB	0.33094830
97	ATR	0.33033369
98	ABL1	0.32582310
99	MAP2K6	0.32259869
100	CHEK2	0.31453050

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.68342208
2	Phototransduction_Homo sapiens_hsa04744	2.68304957
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.62451106
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.49749469
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.35518757
6	Butanoate metabolism_Homo sapiens_hsa00650	2.33846831
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.29158242
8	Protein export_Homo sapiens_hsa03060	2.27927760
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.27280781
10	Homologous recombination_Homo sapiens_hsa03440	2.14460047
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.11575768
12	Basal transcription factors_Homo sapiens_hsa03022	2.04719556
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.99335480
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.92200180
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.91398065
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90961932
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.86032021
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.80385714
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75418241
20	Nicotine addiction_Homo sapiens_hsa05033	1.70723513
21	Parkinsons disease_Homo sapiens_hsa05012	1.68557940
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.61852622
23	Regulation of autophagy_Homo sapiens_hsa04140	1.58438028
24	Caffeine metabolism_Homo sapiens_hsa00232	1.49779193
25	RNA polymerase_Homo sapiens_hsa03020	1.46723567
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.39633002
27	RNA degradation_Homo sapiens_hsa03018	1.35746921
28	Proteasome_Homo sapiens_hsa03050	1.27189474
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.27048463
30	Olfactory transduction_Homo sapiens_hsa04740	1.25470777
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.24783558
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24238379
33	Propanoate metabolism_Homo sapiens_hsa00640	1.23048489
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.22173827
35	Peroxisome_Homo sapiens_hsa04146	1.19540530
36	Morphine addiction_Homo sapiens_hsa05032	1.19422164
37	Taste transduction_Homo sapiens_hsa04742	1.15601860
38	Huntingtons disease_Homo sapiens_hsa05016	1.12454317
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08888870
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05861744
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05514836
42	GABAergic synapse_Homo sapiens_hsa04727	1.03185216
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.02471139
44	Insulin secretion_Homo sapiens_hsa04911	1.01273684
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01156582
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00973956
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99901317
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.99728807
49	ABC transporters_Homo sapiens_hsa02010	0.99230458
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99078363
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97327497
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.91647851
53	Retinol metabolism_Homo sapiens_hsa00830	0.90929794
54	Alzheimers disease_Homo sapiens_hsa05010	0.88823127
55	Serotonergic synapse_Homo sapiens_hsa04726	0.88004328
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87556437
57	Circadian rhythm_Homo sapiens_hsa04710	0.87249559
58	Circadian entrainment_Homo sapiens_hsa04713	0.80954700
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79811547
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78025338
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77463230
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77414944
63	One carbon pool by folate_Homo sapiens_hsa00670	0.76592219
64	Purine metabolism_Homo sapiens_hsa00230	0.76107310
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.76018909
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.75589415
67	Fatty acid elongation_Homo sapiens_hsa00062	0.75393811
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.74705972
69	Sulfur metabolism_Homo sapiens_hsa00920	0.74645326
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.67405114
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67233477
72	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.65651413
73	Metabolic pathways_Homo sapiens_hsa01100	0.65224536
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63026402
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62784674
76	Cocaine addiction_Homo sapiens_hsa05030	0.61133853
77	Fatty acid degradation_Homo sapiens_hsa00071	0.60237390
78	Dopaminergic synapse_Homo sapiens_hsa04728	0.60057808
79	RNA transport_Homo sapiens_hsa03013	0.59278218
80	Mineral absorption_Homo sapiens_hsa04978	0.58086885
81	Asthma_Homo sapiens_hsa05310	0.57457018
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.56412452
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56211503
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56033383
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.55583745
86	Histidine metabolism_Homo sapiens_hsa00340	0.54832033
87	Type I diabetes mellitus_Homo sapiens_hsa04940	0.52928907
88	Salivary secretion_Homo sapiens_hsa04970	0.52680874
89	Amphetamine addiction_Homo sapiens_hsa05031	0.49096886
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48873724
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.48286586
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47237780
93	Base excision repair_Homo sapiens_hsa03410	0.45215163
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44424646
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.42608834
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42105957
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38377127
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34882624
99	p53 signaling pathway_Homo sapiens_hsa04115	0.34051009
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33262428

TERB2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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