TERF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.44291379
2mitotic metaphase plate congression (GO:0007080)4.96700746
3L-serine metabolic process (GO:0006563)4.60825963
4kinetochore organization (GO:0051383)4.59470567
5IMP biosynthetic process (GO:0006188)4.56803634
6CENP-A containing nucleosome assembly (GO:0034080)4.46601004
7chromatin remodeling at centromere (GO:0031055)4.44615868
8kinetochore assembly (GO:0051382)4.41297237
9metaphase plate congression (GO:0051310)4.37452777
10DNA replication checkpoint (GO:0000076)4.29799594
11protein localization to kinetochore (GO:0034501)4.15816357
12telomere maintenance via semi-conservative replication (GO:0032201)4.12668691
13pre-miRNA processing (GO:0031054)4.11699092
14IMP metabolic process (GO:0046040)4.09922576
15DNA strand elongation involved in DNA replication (GO:0006271)4.06966589
16DNA replication initiation (GO:0006270)4.06785977
17establishment of viral latency (GO:0019043)4.04658547
18establishment of chromosome localization (GO:0051303)3.95805396
19attachment of spindle microtubules to kinetochore (GO:0008608)3.95617942
20mitotic sister chromatid segregation (GO:0000070)3.92456577
21DNA strand elongation (GO:0022616)3.92369208
22DNA replication-independent nucleosome organization (GO:0034724)3.91692433
23DNA replication-independent nucleosome assembly (GO:0006336)3.91692433
24meiotic chromosome segregation (GO:0045132)3.91097368
25telomere maintenance via recombination (GO:0000722)3.85478511
26protein localization to chromosome, centromeric region (GO:0071459)3.80194930
27protein K6-linked ubiquitination (GO:0085020)3.79600697
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.78775370
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.78775370
30regulation of translation, ncRNA-mediated (GO:0045974)3.78775370
31heterochromatin organization (GO:0070828)3.76988830
32histone exchange (GO:0043486)3.76222352
33microtubule depolymerization (GO:0007019)3.72858747
34ribosome assembly (GO:0042255)3.72271449
35protein complex localization (GO:0031503)3.71562269
36DNA deamination (GO:0045006)3.70722168
37mitotic recombination (GO:0006312)3.69707842
38maturation of SSU-rRNA (GO:0030490)3.67421297
39* regulation of nuclear cell cycle DNA replication (GO:0033262)3.65672831
40DNA damage response, detection of DNA damage (GO:0042769)3.63209714
41nuclear pore organization (GO:0006999)3.57736468
42nucleobase biosynthetic process (GO:0046112)3.56574374
43purine nucleobase biosynthetic process (GO:0009113)3.55947091
44negative regulation of DNA recombination (GO:0045910)3.53050191
45response to X-ray (GO:0010165)3.52978510
46regulation of double-strand break repair via homologous recombination (GO:0010569)3.52125295
47regulation of spindle organization (GO:0090224)3.50719690
48ribosome biogenesis (GO:0042254)3.49967860
49rRNA modification (GO:0000154)3.46038479
50* telomere maintenance via telomere lengthening (GO:0010833)3.45831343
51nuclear pore complex assembly (GO:0051292)3.42658902
52* spindle checkpoint (GO:0031577)3.41208542
53maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.40069706
54sister chromatid segregation (GO:0000819)3.39906503
55mitotic nuclear envelope disassembly (GO:0007077)3.39586140
56ribosomal large subunit biogenesis (GO:0042273)3.36451594
57mitotic G2/M transition checkpoint (GO:0044818)3.32683528
58maturation of 5.8S rRNA (GO:0000460)3.32551564
59chaperone-mediated protein transport (GO:0072321)3.31952909
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31137048
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29174585
62DNA replication-dependent nucleosome organization (GO:0034723)3.28636115
63DNA replication-dependent nucleosome assembly (GO:0006335)3.28636115
64regulation of helicase activity (GO:0051095)3.28576497
65ribonucleoprotein complex biogenesis (GO:0022613)3.28575025
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27615636
67ATP-dependent chromatin remodeling (GO:0043044)3.27516084
68* negative regulation of chromosome segregation (GO:0051985)3.26649955
69* negative regulation of sister chromatid segregation (GO:0033046)3.25108657
70* negative regulation of mitotic sister chromatid separation (GO:2000816)3.25108657
71* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25108657
72* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25108657
73* spindle assembly checkpoint (GO:0071173)3.23773113
74DNA catabolic process, exonucleolytic (GO:0000738)3.22830673
75lysine catabolic process (GO:0006554)3.20264247
76lysine metabolic process (GO:0006553)3.20264247
77establishment of protein localization to mitochondrial membrane (GO:0090151)3.19711035
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18760206
79DNA double-strand break processing (GO:0000729)3.18732510
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.17079775
81* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16500456
82rRNA processing (GO:0006364)3.16392864
83* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.16128192
84double-strand break repair via nonhomologous end joining (GO:0006303)3.15754672
85non-recombinational repair (GO:0000726)3.15754672
86transcription-coupled nucleotide-excision repair (GO:0006283)3.15497153
87* mitotic spindle checkpoint (GO:0071174)3.15096258
88* mitotic spindle assembly checkpoint (GO:0007094)3.14273336
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13717010
90termination of RNA polymerase I transcription (GO:0006363)3.11827029
91replication fork processing (GO:0031297)3.11646659
92DNA strand renaturation (GO:0000733)3.11574887
93termination of RNA polymerase III transcription (GO:0006386)3.11363546
94transcription elongation from RNA polymerase III promoter (GO:0006385)3.11363546
95spliceosomal snRNP assembly (GO:0000387)3.10823879
96* regulation of chromosome segregation (GO:0051983)3.10436595
97mitotic sister chromatid cohesion (GO:0007064)3.10000769
98* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.09808662
99mismatch repair (GO:0006298)3.09086521
100nuclear envelope disassembly (GO:0051081)3.08745317
101membrane disassembly (GO:0030397)3.08745317
102protein neddylation (GO:0045116)3.08618144
103rRNA metabolic process (GO:0016072)3.07490161
104formation of translation preinitiation complex (GO:0001731)3.07342877
105regulation of centriole replication (GO:0046599)3.07299694
106DNA ligation (GO:0006266)3.07020527
107transcription elongation from RNA polymerase I promoter (GO:0006362)3.05251278
108* regulation of sister chromatid segregation (GO:0033045)3.04867980
109* regulation of mitotic sister chromatid separation (GO:0010965)3.04867980
110* regulation of mitotic sister chromatid segregation (GO:0033047)3.04867980
111somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.04370054
112isotype switching (GO:0045190)3.04370054
113somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.04370054
114serine family amino acid biosynthetic process (GO:0009070)3.04037665
115mitotic chromosome condensation (GO:0007076)3.03991264
116regulation of mitotic spindle organization (GO:0060236)3.03857793
117chromosome segregation (GO:0007059)3.03664710
118proteasome assembly (GO:0043248)3.03114811
119* negative regulation of mitosis (GO:0045839)3.02210871
120histone mRNA metabolic process (GO:0008334)3.02121380
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02017835
122pseudouridine synthesis (GO:0001522)3.01386947
123transcription from RNA polymerase I promoter (GO:0006360)3.01140989
124somatic hypermutation of immunoglobulin genes (GO:0016446)3.01036794
125somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01036794
126negative regulation of ligase activity (GO:0051352)3.00498923
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00498923
128rRNA methylation (GO:0031167)2.99830925
129* negative regulation of DNA-dependent DNA replication (GO:2000104)2.99778859
130chromatin assembly or disassembly (GO:0006333)2.99685236
131regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98219196
132regulation of mitotic spindle checkpoint (GO:1903504)2.98219196
133ribosomal small subunit assembly (GO:0000028)2.97318668
134regulation of histone H3-K9 methylation (GO:0051570)2.97023371
135anterior/posterior axis specification, embryo (GO:0008595)2.96451156
136DNA unwinding involved in DNA replication (GO:0006268)2.96051048
137protein localization to chromosome (GO:0034502)2.95532565
138regulation of centrosome cycle (GO:0046605)2.95132124
139regulation of spindle checkpoint (GO:0090231)2.94899171
140positive regulation of chromosome segregation (GO:0051984)2.94574074
141DNA-dependent DNA replication (GO:0006261)2.92434039
1427-methylguanosine mRNA capping (GO:0006370)2.91945836
143regulation of gene silencing by RNA (GO:0060966)2.90683603
144regulation of posttranscriptional gene silencing (GO:0060147)2.90683603
145regulation of gene silencing by miRNA (GO:0060964)2.90683603
146intra-S DNA damage checkpoint (GO:0031573)2.89443141
147cell fate commitment involved in formation of primary germ layer (GO:0060795)2.89010884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55400413
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.99273218
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.18054848
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.03611591
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.72708939
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.46999715
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.94841706
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93512035
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.83665416
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81258276
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80511250
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74936636
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.62990134
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61336043
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45709828
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41113720
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39566902
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35437905
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33967763
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28736205
21VDR_23849224_ChIP-Seq_CD4+_Human2.26966567
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26403353
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14361530
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13467753
25XRN2_22483619_ChIP-Seq_HELA_Human2.09041667
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08030079
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.04678463
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03847192
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.99681342
30AR_21909140_ChIP-Seq_LNCAP_Human1.99392128
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.97697077
32* E2F1_21310950_ChIP-Seq_MCF-7_Human1.97157710
33SOX2_16153702_ChIP-ChIP_HESCs_Human1.96766610
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95861520
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94269089
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.86345421
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.86345421
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.86345421
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85800466
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85319994
41ELK1_19687146_ChIP-ChIP_HELA_Human1.81838794
42DCP1A_22483619_ChIP-Seq_HELA_Human1.79963334
43EWS_26573619_Chip-Seq_HEK293_Human1.78935085
44TTF2_22483619_ChIP-Seq_HELA_Human1.76342792
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72721436
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70838146
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66417510
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.63687404
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63597306
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63237925
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.62612754
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61534961
53GABP_19822575_ChIP-Seq_HepG2_Human1.59930728
54ZNF274_21170338_ChIP-Seq_K562_Hela1.59264672
55FUS_26573619_Chip-Seq_HEK293_Human1.57185082
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54803491
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.54304454
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.53438228
59* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51171903
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49230202
61* FLI1_27457419_Chip-Seq_LIVER_Mouse1.48801916
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48149201
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.45437358
64VDR_22108803_ChIP-Seq_LS180_Human1.40243672
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.37956497
66CIITA_25753668_ChIP-Seq_RAJI_Human1.35354840
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33875839
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31477488
69P300_19829295_ChIP-Seq_ESCs_Human1.30345557
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28398161
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27012398
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25394984
73KDM5A_27292631_Chip-Seq_BREAST_Human1.25023342
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21908008
75NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.20380711
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17101887
77* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14640901
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14080016
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11168115
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10286964
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10253975
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08336370
83MYC_18940864_ChIP-ChIP_HL60_Human1.08216919
84* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06746886
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06630980
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05783310
87* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05486239
88TAF15_26573619_Chip-Seq_HEK293_Human1.03425496
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03197110
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01111700
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.00190272
92TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00175903
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97454053
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96678175
95IGF1R_20145208_ChIP-Seq_DFB_Human0.95086670
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93526710
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93298403
98* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92576255
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92401595
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90072001
101* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90023953
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89090693
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88679910
104IRF1_19129219_ChIP-ChIP_H3396_Human0.87353204
105TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87223209
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86462045
107TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85938757
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85723366
109TFEB_21752829_ChIP-Seq_HELA_Human0.85320791
110PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83611857
111SPI1_23547873_ChIP-Seq_NB4_Human0.81754845
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.79646438
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79333343
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78646006
115* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78501197
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78395114
117ELK1_22589737_ChIP-Seq_MCF10A_Human0.78141060
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78089227
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.77841738
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77759376
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77441552
122* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76142501
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76031452
124* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74969207
125* NANOG_16153702_ChIP-ChIP_HESCs_Human0.74430752
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.73653779
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72797069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.20123754
2MP0010094_abnormal_chromosome_stability4.80614673
3* MP0003111_abnormal_nucleus_morphology4.61283127
4MP0008057_abnormal_DNA_replication4.43737279
5MP0002254_reproductive_system_inflammat4.05420235
6MP0008058_abnormal_DNA_repair3.99157378
7MP0003077_abnormal_cell_cycle3.94593893
8MP0004957_abnormal_blastocyst_morpholog3.92788749
9MP0008877_abnormal_DNA_methylation2.79315801
10MP0003786_premature_aging2.64814767
11MP0006292_abnormal_olfactory_placode2.62860774
12MP0000566_synostosis2.60414782
13* MP0008932_abnormal_embryonic_tissue2.56166222
14* MP0008007_abnormal_cellular_replicative2.52164786
15MP0009672_abnormal_birth_weight2.51615070
16MP0003718_maternal_effect2.36057514
17MP0002396_abnormal_hematopoietic_system2.17383643
18* MP0000350_abnormal_cell_proliferation1.93164716
19MP0003136_yellow_coat_color1.87293586
20MP0003123_paternal_imprinting1.84968335
21* MP0003941_abnormal_skin_development1.77819373
22MP0001730_embryonic_growth_arrest1.69915788
23MP0010030_abnormal_orbit_morphology1.62581706
24MP0002210_abnormal_sex_determination1.62312355
25MP0005380_embryogenesis_phenotype1.53538007
26MP0001672_abnormal_embryogenesis/_devel1.53538007
27MP0009703_decreased_birth_body1.53014848
28MP0001293_anophthalmia1.43933628
29MP0000490_abnormal_crypts_of1.41933302
30MP0001177_atelectasis1.41888837
31MP0001697_abnormal_embryo_size1.39869993
32MP0001485_abnormal_pinna_reflex1.38537989
33MP0006072_abnormal_retinal_apoptosis1.38415320
34MP0000313_abnormal_cell_death1.38174698
35MP0002736_abnormal_nociception_after1.36576537
36MP0002085_abnormal_embryonic_tissue1.36558294
37MP0001145_abnormal_male_reproductive1.35403417
38MP0006035_abnormal_mitochondrial_morpho1.34991744
39MP0003122_maternal_imprinting1.34702216
40MP0001929_abnormal_gametogenesis1.34458601
41MP0002697_abnormal_eye_size1.33929672
42MP0010307_abnormal_tumor_latency1.32167458
43MP0001529_abnormal_vocalization1.28274347
44MP0003890_abnormal_embryonic-extraembry1.27946091
45MP0003984_embryonic_growth_retardation1.26844088
46MP0003315_abnormal_perineum_morphology1.25976069
47MP0000653_abnormal_sex_gland1.23229074
48MP0003121_genomic_imprinting1.22934549
49MP0002088_abnormal_embryonic_growth/wei1.22800095
50MP0001119_abnormal_female_reproductive1.22736727
51MP0002132_abnormal_respiratory_system1.20195774
52MP0002160_abnormal_reproductive_system1.18790165
53* MP0002019_abnormal_tumor_incidence1.18393760
54* MP0002080_prenatal_lethality1.18308476
55MP0002102_abnormal_ear_morphology1.16471254
56MP0002084_abnormal_developmental_patter1.15188737
57MP0004808_abnormal_hematopoietic_stem1.13107864
58MP0004381_abnormal_hair_follicle1.10980286
59* MP0002086_abnormal_extraembryonic_tissu1.09901341
60MP0004133_heterotaxia1.09446518
61MP0001986_abnormal_taste_sensitivity1.08766516
62MP0005389_reproductive_system_phenotype1.06899093
63MP0008995_early_reproductive_senescence1.06245239
64MP0002277_abnormal_respiratory_mucosa1.06216253
65MP0001299_abnormal_eye_distance/1.05441548
66MP0002090_abnormal_vision1.03562827
67MP0002233_abnormal_nose_morphology1.03206914
68MP0008789_abnormal_olfactory_epithelium1.01406847
69MP0000015_abnormal_ear_pigmentation1.00729548
70MP0003937_abnormal_limbs/digits/tail_de1.00502681
71MP0005075_abnormal_melanosome_morpholog0.98587984
72MP0010352_gastrointestinal_tract_polyps0.97442454
73MP0001286_abnormal_eye_development0.97219832
74MP0003787_abnormal_imprinting0.95263849
75MP0003011_delayed_dark_adaptation0.94527753
76MP0009333_abnormal_splenocyte_physiolog0.94011484
77MP0003763_abnormal_thymus_physiology0.92914789
78MP0000703_abnormal_thymus_morphology0.92668714
79MP0001984_abnormal_olfaction0.92174634
80MP0009697_abnormal_copulation0.91261682
81MP0004197_abnormal_fetal_growth/weight/0.91141094
82MP0009379_abnormal_foot_pigmentation0.90553289
83MP0003861_abnormal_nervous_system0.88216673
84MP0003878_abnormal_ear_physiology0.87921795
85MP0005377_hearing/vestibular/ear_phenot0.87921795
86MP0001919_abnormal_reproductive_system0.86465162
87MP0002653_abnormal_ependyma_morphology0.84882983
88MP0002095_abnormal_skin_pigmentation0.84536187
89MP0003567_abnormal_fetal_cardiomyocyte0.82734267
90MP0003806_abnormal_nucleotide_metabolis0.82650854
91MP0003938_abnormal_ear_development0.81053137
92MP0000049_abnormal_middle_ear0.81021799
93MP0002398_abnormal_bone_marrow0.80950398
94MP0002722_abnormal_immune_system0.79481508
95MP0000858_altered_metastatic_potential0.78465531
96MP0002111_abnormal_tail_morphology0.77655937
97MP0003698_abnormal_male_reproductive0.77338040
98MP0005174_abnormal_tail_pigmentation0.76939344
99MP0000689_abnormal_spleen_morphology0.76768311
100MP0008260_abnormal_autophagy0.75821402
101MP0002075_abnormal_coat/hair_pigmentati0.75538357
102MP0006036_abnormal_mitochondrial_physio0.74208863
103MP0005397_hematopoietic_system_phenotyp0.74064352
104MP0001545_abnormal_hematopoietic_system0.74064352
105MP0003195_calcinosis0.72197786
106MP0000631_abnormal_neuroendocrine_gland0.71908017
107MP0008770_decreased_survivor_rate0.71620893
108MP0005394_taste/olfaction_phenotype0.71369260
109MP0005499_abnormal_olfactory_system0.71369260
110MP0003119_abnormal_digestive_system0.71109687
111MP0002751_abnormal_autonomic_nervous0.70990054
112MP0002938_white_spotting0.70756212
113MP0000428_abnormal_craniofacial_morphol0.70652355
114MP0002249_abnormal_larynx_morphology0.70339742
115* MP0001186_pigmentation_phenotype0.69348461
116MP0002009_preneoplasia0.69123165
117MP0003699_abnormal_female_reproductive0.68239979
118MP0005395_other_phenotype0.68094965
119MP0004215_abnormal_myocardial_fiber0.67780121
120MP0005384_cellular_phenotype0.66089150
121MP0000371_diluted_coat_color0.64894738
122MP0002092_abnormal_eye_morphology0.64677161
123MP0000432_abnormal_head_morphology0.64522717
124MP0003137_abnormal_impulse_conducting0.63967673
125MP0005391_vision/eye_phenotype0.63879709
126MP0000613_abnormal_salivary_gland0.63439044
127MP0003186_abnormal_redox_activity0.63413922
128MP0005621_abnormal_cell_physiology0.63067257
129MP0000358_abnormal_cell_content/0.62435400
130MP0003936_abnormal_reproductive_system0.61174978
131MP0002429_abnormal_blood_cell0.60966420
132MP0004264_abnormal_extraembryonic_tissu0.60516032
133* MP0003755_abnormal_palate_morphology0.60371094
134MP0005253_abnormal_eye_physiology0.59568090
135MP0001968_abnormal_touch/_nociception0.56472511
136MP0005551_abnormal_eye_electrophysiolog0.53235106
137MP0002161_abnormal_fertility/fecundity0.52251456
138* MP0002081_perinatal_lethality0.51815275
139MP0001324_abnormal_eye_pigmentation0.49609995

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.85176513
2Chromsome breakage (HP:0040012)5.68789440
3Birth length less than 3rd percentile (HP:0003561)4.63641826
4Breast hypoplasia (HP:0003187)3.99705312
5Meckel diverticulum (HP:0002245)3.95730179
6Abnormality of the preputium (HP:0100587)3.87228882
7Abnormality of the ileum (HP:0001549)3.77582159
8Reticulocytopenia (HP:0001896)3.75476699
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.74661754
10Abnormality of chromosome stability (HP:0003220)3.73339175
11Duplicated collecting system (HP:0000081)3.71373759
12Septo-optic dysplasia (HP:0100842)3.67697177
13Absent radius (HP:0003974)3.64274500
14Aplasia involving forearm bones (HP:0009822)3.43043853
15Absent forearm bone (HP:0003953)3.43043853
16Abnormality of the renal collecting system (HP:0004742)3.40901815
17Patellar aplasia (HP:0006443)3.21953983
18Impulsivity (HP:0100710)3.21551520
19Absent thumb (HP:0009777)3.05761361
20Aplasia/Hypoplasia of the patella (HP:0006498)3.00436038
21Small intestinal stenosis (HP:0012848)2.99405186
22Duodenal stenosis (HP:0100867)2.99405186
23Abnormality of the labia minora (HP:0012880)2.96576295
24Supernumerary spleens (HP:0009799)2.94769816
25Ectopic kidney (HP:0000086)2.91171814
26Abnormality of serum amino acid levels (HP:0003112)2.85972185
27Multiple enchondromatosis (HP:0005701)2.85780208
28Carpal bone hypoplasia (HP:0001498)2.79995789
29Myelodysplasia (HP:0002863)2.79905953
30Clubbing of toes (HP:0100760)2.78129997
31Pancreatic islet-cell hyperplasia (HP:0004510)2.77242081
32Oral leukoplakia (HP:0002745)2.72106753
33Medulloblastoma (HP:0002885)2.71953004
34Bone marrow hypocellularity (HP:0005528)2.71239101
35Hyperglycinemia (HP:0002154)2.70388476
36Triphalangeal thumb (HP:0001199)2.68322480
37Spastic diplegia (HP:0001264)2.68177579
38Hypoglycemic seizures (HP:0002173)2.65565026
39Abnormal hair whorl (HP:0010721)2.59298533
40Abnormality of homocysteine metabolism (HP:0010919)2.57985898
41Homocystinuria (HP:0002156)2.57985898
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.57853959
43Colon cancer (HP:0003003)2.57303420
44Abnormality of DNA repair (HP:0003254)2.56416925
45Aplastic anemia (HP:0001915)2.55265007
46Bilateral microphthalmos (HP:0007633)2.54015062
47Rough bone trabeculation (HP:0100670)2.53598322
48Abnormality of methionine metabolism (HP:0010901)2.51407980
49Abnormality of serine family amino acid metabolism (HP:0010894)2.51013411
50Abnormality of glycine metabolism (HP:0010895)2.51013411
51Horseshoe kidney (HP:0000085)2.48747659
52Sloping forehead (HP:0000340)2.44208538
53Abnormality of the duodenum (HP:0002246)2.42916591
54Absent septum pellucidum (HP:0001331)2.41443803
55Glioma (HP:0009733)2.37324683
56Hyperglycinuria (HP:0003108)2.37316720
57Chronic bronchitis (HP:0004469)2.34270833
58Agnosia (HP:0010524)2.34122123
59Methylmalonic acidemia (HP:0002912)2.33746309
60Abnormal lung lobation (HP:0002101)2.32452037
61Abnormality of the septum pellucidum (HP:0007375)2.29689919
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29156856
63Duplication of thumb phalanx (HP:0009942)2.28810983
64Abnormality of the carotid arteries (HP:0005344)2.26541292
65Abnormal spermatogenesis (HP:0008669)2.26469667
66Hyperinsulinemic hypoglycemia (HP:0000825)2.26240578
67Nephroblastoma (Wilms tumor) (HP:0002667)2.25816112
68Cortical dysplasia (HP:0002539)2.25633934
69Short thumb (HP:0009778)2.24985243
7011 pairs of ribs (HP:0000878)2.24459231
71Choanal stenosis (HP:0000452)2.21610069
72Hepatoblastoma (HP:0002884)2.20931118
73Neoplasm of the colon (HP:0100273)2.20605512
74Premature graying of hair (HP:0002216)2.19263770
75Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19206734
76Ureteral duplication (HP:0000073)2.18599409
77Megaloblastic anemia (HP:0001889)2.17982635
78Selective tooth agenesis (HP:0001592)2.17812971
79Increased hepatocellular lipid droplets (HP:0006565)2.17379689
80Acute encephalopathy (HP:0006846)2.17315843
81Tracheoesophageal fistula (HP:0002575)2.16195032
82Abnormality of the anterior horn cell (HP:0006802)2.15418776
83Degeneration of anterior horn cells (HP:0002398)2.15418776
84Abnormality of cells of the erythroid lineage (HP:0012130)2.13320125
85Biliary tract neoplasm (HP:0100574)2.12918795
86Acute necrotizing encephalopathy (HP:0006965)2.11335825
87Embryonal renal neoplasm (HP:0011794)2.10575286
88Aplasia/Hypoplasia of the earlobes (HP:0009906)2.09213688
89Neoplasm of the adrenal gland (HP:0100631)2.05974994
90Cleft eyelid (HP:0000625)2.05404729
91Abnormal number of erythroid precursors (HP:0012131)2.04988278
92Hypoplastic female external genitalia (HP:0012815)2.04911235
93Abolished electroretinogram (ERG) (HP:0000550)2.04320616
94Hypoplasia of the radius (HP:0002984)2.02884735
95Type I transferrin isoform profile (HP:0003642)2.00385247
96Neoplasm of the adrenal cortex (HP:0100641)2.00103982
97Rhabdomyosarcoma (HP:0002859)1.99032750
98Maternal diabetes (HP:0009800)1.98892902
99Abnormality of the clitoris (HP:0000056)1.97556727
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97294048
101Bifid tongue (HP:0010297)1.96996772
102Methylmalonic aciduria (HP:0012120)1.96310660
103Abdominal situs inversus (HP:0003363)1.96167208
104Abnormality of abdominal situs (HP:0011620)1.96167208
105Abnormality of the astrocytes (HP:0100707)1.94520467
106Astrocytoma (HP:0009592)1.94520467
107Optic nerve hypoplasia (HP:0000609)1.94467127
108Abnormality of pyrimidine metabolism (HP:0004353)1.94327328
109Neoplasm of the pancreas (HP:0002894)1.93835540
110Symptomatic seizures (HP:0011145)1.92771014
111Abnormal trabecular bone morphology (HP:0100671)1.90123762
112Lipid accumulation in hepatocytes (HP:0006561)1.89329733
113Pallor (HP:0000980)1.89187772
114Embryonal neoplasm (HP:0002898)1.88916385
115Increased nuchal translucency (HP:0010880)1.88292580
116Abnormal number of incisors (HP:0011064)1.87735549
117Esophageal atresia (HP:0002032)1.86493944
118Pendular nystagmus (HP:0012043)1.85919648
119Labial hypoplasia (HP:0000066)1.85765636
120Facial hemangioma (HP:0000329)1.83017766
121Macrocytic anemia (HP:0001972)1.82364515
122Hypoplasia of the pons (HP:0012110)1.82198256
123Scrotal hypoplasia (HP:0000046)1.80930024
124Premature ovarian failure (HP:0008209)1.80354467
125Neoplasm of striated muscle (HP:0009728)1.80078377
126Cellular immunodeficiency (HP:0005374)1.79610455
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.79415354
128Cerebral hypomyelination (HP:0006808)1.79351492
129Facial cleft (HP:0002006)1.78375351
130Atresia of the external auditory canal (HP:0000413)1.78142213
131Microvesicular hepatic steatosis (HP:0001414)1.78005999
132Intestinal atresia (HP:0011100)1.77946636
133Breast aplasia (HP:0100783)1.77419827
134Shawl scrotum (HP:0000049)1.77417796
135Gonadotropin excess (HP:0000837)1.77154065
136Breast carcinoma (HP:0003002)1.76327957
137Azoospermia (HP:0000027)1.75994398
138Ependymoma (HP:0002888)1.75363103
139Clitoromegaly (HP:0000057)1.74019322
140Abnormality of sulfur amino acid metabolism (HP:0004339)1.73805922
141Type 2 muscle fiber atrophy (HP:0003554)1.73595286
142Neoplasm of the oral cavity (HP:0100649)1.73591818
143Lymphoma (HP:0002665)1.73207504
144Sparse eyelashes (HP:0000653)1.73182486
145Dandy-Walker malformation (HP:0001305)1.73075543
146Pancytopenia (HP:0001876)1.72009524
147Squamous cell carcinoma (HP:0002860)1.71448851
148Acute lymphatic leukemia (HP:0006721)1.69845295
149Oligodactyly (HP:0012165)1.69549242
150Aplasia/Hypoplasia of the breasts (HP:0010311)1.69343651
151Capillary hemangiomas (HP:0005306)1.66419175
152Rib fusion (HP:0000902)1.65708746
153Leukopenia (HP:0001882)1.65352094
154Volvulus (HP:0002580)1.65162999
155Choanal atresia (HP:0000453)1.64587345
156Muscle fiber atrophy (HP:0100295)1.62445567
157Supernumerary bones of the axial skeleton (HP:0009144)1.59520401
158Abnormality of cochlea (HP:0000375)1.58391226
159Stenosis of the external auditory canal (HP:0000402)1.58094343
160Pancreatic cysts (HP:0001737)1.57747226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.32576914
2WEE14.04886756
3TNIK3.21772286
4CDC73.09305017
5PLK42.95505864
6VRK22.93454490
7EIF2AK12.89580510
8TTK2.80408933
9SRPK12.79896137
10TAF12.69201349
11STK162.68564472
12NEK22.60279737
13BRSK22.41405163
14ZAK2.39519258
15MKNK22.27454295
16WNK32.20782725
17TRIM282.15324474
18* PLK12.08476903
19MKNK11.98194940
20EIF2AK31.97046060
21AKT31.96298584
22ACVR1B1.93240932
23EPHA21.89432894
24VRK11.86511775
25TSSK61.80653455
26IRAK31.76697452
27PLK31.73356684
28ATR1.64565217
29CDK71.64225383
30AURKB1.63633062
31CHEK21.61696251
32TLK11.59199672
33CDK121.57355056
34DYRK31.52807827
35EIF2AK21.46499123
36NEK11.43446268
37NME21.36065425
38RPS6KB21.35907598
39NME11.33880473
40CDK191.26384779
41AURKA1.23344509
42CDK81.22814756
43IRAK41.19466496
44BRD41.15476195
45CHEK11.15261965
46STK38L1.14167627
47BRSK11.11590902
48STK41.10820751
49CCNB11.00549235
50PASK0.99474646
51TESK20.99211764
52CDK40.98409045
53CASK0.98327958
54CSNK1G10.94328135
55STK100.93463482
56BRAF0.93019324
57* ATM0.90761736
58OXSR10.87281525
59RPS6KA40.86806970
60FGFR10.86597478
61PBK0.81199499
62MAP3K100.80139488
63PIM10.79939579
64PNCK0.79866629
65TXK0.79333557
66MAP3K80.79069354
67YES10.78334802
68CDK20.74308576
69MST40.73924614
70MELK0.71425483
71PRKCI0.67281603
72PLK20.64351564
73CDK30.62885284
74FGFR20.62521072
75TIE10.61919353
76MAP4K20.59395896
77* CDK10.59294667
78STK240.59133199
79CSNK1G20.59058750
80* CSNK2A10.58775298
81BCR0.58293266
82NUAK10.58270701
83PIM20.57501964
84CSNK2A20.56985777
85CLK10.55082093
86FLT30.54885874
87STK30.54842352
88NLK0.52021143
89ERBB40.51900316
90DMPK0.51001099
91TEC0.50865255
92PRKCG0.49077124
93SMG10.48783491
94RPS6KA50.48700847
95NEK60.46342840
96CSNK1G30.45722990
97DAPK10.42316088
98IRAK10.40497013
99TGFBR10.40440710
100BMPR1B0.40394572
101INSRR0.39611386
102FRK0.37943415
103MARK30.37310574
104IKBKB0.35681483
105PAK10.34995301
106CDK90.32605062
107IRAK20.31837890
108CSNK1A1L0.31354750
109MAP3K40.31242524
110ADRBK20.31170509
111MAPKAPK30.31041568
112PAK40.30571894
113DYRK20.30315574
114GRK10.29531049
115ALK0.29507853
116CDK60.28910299
117TAOK20.28886383
118CAMK1G0.27626283
119DYRK1A0.27082015
120LATS10.26825924
121CSNK1A10.26334564
122PRKCE0.25777141
123NEK90.24450148
124MAPK140.23899549
125AKT20.23834385
126ERBB30.23524922
127PDK20.22662085
128CHUK0.22524684
129CSNK1E0.22361429
130EGFR0.21620502
131* PRKDC0.21406613
132MAP3K60.21142138
133PINK10.20912891
134MAP2K30.20769654
135MINK10.20048831
136CAMK1D0.18640250
137MAP3K140.18292661
138CSNK1D0.18085980

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47306058
2Mismatch repair_Homo sapiens_hsa034304.08914170
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.87672291
4Homologous recombination_Homo sapiens_hsa034403.57288067
5RNA polymerase_Homo sapiens_hsa030203.54706938
6Fanconi anemia pathway_Homo sapiens_hsa034603.19195820
7Spliceosome_Homo sapiens_hsa030403.15528090
8Base excision repair_Homo sapiens_hsa034103.02064280
9RNA transport_Homo sapiens_hsa030132.93626110
10Nucleotide excision repair_Homo sapiens_hsa034202.88420094
11Ribosome_Homo sapiens_hsa030102.86741185
12Cell cycle_Homo sapiens_hsa041102.76844630
13Proteasome_Homo sapiens_hsa030502.70444785
14Basal transcription factors_Homo sapiens_hsa030222.60496332
15Pyrimidine metabolism_Homo sapiens_hsa002402.47126731
16Non-homologous end-joining_Homo sapiens_hsa034502.38205804
17One carbon pool by folate_Homo sapiens_hsa006702.31723868
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13023568
19RNA degradation_Homo sapiens_hsa030182.08360182
20p53 signaling pathway_Homo sapiens_hsa041151.80434821
21mRNA surveillance pathway_Homo sapiens_hsa030151.78730595
22Propanoate metabolism_Homo sapiens_hsa006401.67948419
23Steroid biosynthesis_Homo sapiens_hsa001001.58058240
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56155311
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55989215
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49081262
27Pyruvate metabolism_Homo sapiens_hsa006201.47837896
28Parkinsons disease_Homo sapiens_hsa050121.45820183
29Oxidative phosphorylation_Homo sapiens_hsa001901.45500443
30Purine metabolism_Homo sapiens_hsa002301.44920369
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43297652
32Vitamin B6 metabolism_Homo sapiens_hsa007501.39405953
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33414588
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30473744
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20676362
36Epstein-Barr virus infection_Homo sapiens_hsa051691.19583488
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10415105
38Fatty acid elongation_Homo sapiens_hsa000621.07958959
39Herpes simplex infection_Homo sapiens_hsa051681.03192692
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98971925
41Systemic lupus erythematosus_Homo sapiens_hsa053220.96151109
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91740873
43Oocyte meiosis_Homo sapiens_hsa041140.90051890
44Carbon metabolism_Homo sapiens_hsa012000.86481129
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83251749
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81562029
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79038640
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77710430
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77625142
50Alzheimers disease_Homo sapiens_hsa050100.76540910
51Folate biosynthesis_Homo sapiens_hsa007900.75318708
52Protein export_Homo sapiens_hsa030600.74048028
53Primary immunodeficiency_Homo sapiens_hsa053400.73679432
54Antigen processing and presentation_Homo sapiens_hsa046120.72869948
55Viral carcinogenesis_Homo sapiens_hsa052030.71986675
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69237997
57HTLV-I infection_Homo sapiens_hsa051660.67294517
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65762246
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.65033485
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64599813
61MicroRNAs in cancer_Homo sapiens_hsa052060.62104161
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61920184
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.58999812
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.58623264
65beta-Alanine metabolism_Homo sapiens_hsa004100.55959249
66Basal cell carcinoma_Homo sapiens_hsa052170.55420478
67Pentose phosphate pathway_Homo sapiens_hsa000300.55039218
68Retinol metabolism_Homo sapiens_hsa008300.54651936
69Lysine degradation_Homo sapiens_hsa003100.54625650
70Regulation of autophagy_Homo sapiens_hsa041400.54293072
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53101643
72Arachidonic acid metabolism_Homo sapiens_hsa005900.51792311
73Nicotine addiction_Homo sapiens_hsa050330.51766834
74Tight junction_Homo sapiens_hsa045300.51251573
75Fatty acid degradation_Homo sapiens_hsa000710.50244763
76Arginine and proline metabolism_Homo sapiens_hsa003300.48327564
77Allograft rejection_Homo sapiens_hsa053300.48156833
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47960678
79Tryptophan metabolism_Homo sapiens_hsa003800.47762035
80Notch signaling pathway_Homo sapiens_hsa043300.47115057
81Thyroid cancer_Homo sapiens_hsa052160.46460984
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.46460294
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46100437
84Measles_Homo sapiens_hsa051620.45813936
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45318514
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45106495
87TGF-beta signaling pathway_Homo sapiens_hsa043500.44758127
88Fatty acid metabolism_Homo sapiens_hsa012120.44100477
89Cardiac muscle contraction_Homo sapiens_hsa042600.43311100
90Hippo signaling pathway_Homo sapiens_hsa043900.41798438
91Autoimmune thyroid disease_Homo sapiens_hsa053200.41698265
92Hematopoietic cell lineage_Homo sapiens_hsa046400.41450541
93Selenocompound metabolism_Homo sapiens_hsa004500.41033652
94Apoptosis_Homo sapiens_hsa042100.39783280
95Caffeine metabolism_Homo sapiens_hsa002320.39151159
96Huntingtons disease_Homo sapiens_hsa050160.38676765
97Butanoate metabolism_Homo sapiens_hsa006500.36429328
98Graft-versus-host disease_Homo sapiens_hsa053320.36167322
99Legionellosis_Homo sapiens_hsa051340.36134289
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35543541
101Glutathione metabolism_Homo sapiens_hsa004800.35061676
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32849885
103Asthma_Homo sapiens_hsa053100.32776157
104Peroxisome_Homo sapiens_hsa041460.32220059
105Hedgehog signaling pathway_Homo sapiens_hsa043400.32124650
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31769235
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31763680
108Influenza A_Homo sapiens_hsa051640.31073960
109Small cell lung cancer_Homo sapiens_hsa052220.31001510
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30892130
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29708135
112Taste transduction_Homo sapiens_hsa047420.29623288
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.27132834
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26209424
115Pathways in cancer_Homo sapiens_hsa052000.26029410
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24310204
117Phototransduction_Homo sapiens_hsa047440.23717151
118Wnt signaling pathway_Homo sapiens_hsa043100.22659324
119Ether lipid metabolism_Homo sapiens_hsa005650.22510998
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.21878400
121Alcoholism_Homo sapiens_hsa050340.21775305
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21578245
123Linoleic acid metabolism_Homo sapiens_hsa005910.21560657
124Hepatitis B_Homo sapiens_hsa051610.21436158
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21039629
126Fat digestion and absorption_Homo sapiens_hsa049750.20778400
127Metabolic pathways_Homo sapiens_hsa011000.20613245
128Colorectal cancer_Homo sapiens_hsa052100.20028002
129Vitamin digestion and absorption_Homo sapiens_hsa049770.19926577
130Sphingolipid metabolism_Homo sapiens_hsa006000.19769359
131Other glycan degradation_Homo sapiens_hsa005110.19409289
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17963213
133Starch and sucrose metabolism_Homo sapiens_hsa005000.16136713
134Adherens junction_Homo sapiens_hsa045200.16089533
135Shigellosis_Homo sapiens_hsa051310.15776950
136FoxO signaling pathway_Homo sapiens_hsa040680.15662327
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15275005
138Fructose and mannose metabolism_Homo sapiens_hsa000510.14200114
139Prostate cancer_Homo sapiens_hsa052150.14176619
140Renin-angiotensin system_Homo sapiens_hsa046140.13592709
141Sulfur relay system_Homo sapiens_hsa041220.12589053
142Biosynthesis of amino acids_Homo sapiens_hsa012300.11440232
143Bladder cancer_Homo sapiens_hsa052190.10746244
144Melanoma_Homo sapiens_hsa052180.10420663
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.09465488

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