TERF1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.87820967
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.97707507
3chaperone-mediated protein transport (GO:0072321)4.55345867
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.53191533
5regulation of mitotic spindle checkpoint (GO:1903504)4.49087436
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.49087436
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.27280904
8ATP synthesis coupled proton transport (GO:0015986)4.27280904
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.17423967
10protein neddylation (GO:0045116)4.09679417
11chromatin remodeling at centromere (GO:0031055)4.08414091
12proteasome assembly (GO:0043248)4.06518267
13transcription elongation from RNA polymerase III promoter (GO:0006385)4.04661867
14termination of RNA polymerase III transcription (GO:0006386)4.04661867
15respiratory electron transport chain (GO:0022904)4.04264959
16electron transport chain (GO:0022900)3.98243211
17CENP-A containing nucleosome assembly (GO:0034080)3.88037647
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.85231411
19negative regulation of telomere maintenance (GO:0032205)3.84070089
20respiratory chain complex IV assembly (GO:0008535)3.66954511
21DNA damage response, detection of DNA damage (GO:0042769)3.64036309
22histone exchange (GO:0043486)3.54891015
23behavioral response to nicotine (GO:0035095)3.53700793
24DNA double-strand break processing (GO:0000729)3.50795132
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.48344553
26regulation of translation, ncRNA-mediated (GO:0045974)3.48344553
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.48344553
28attachment of spindle microtubules to kinetochore (GO:0008608)3.47138121
29cullin deneddylation (GO:0010388)3.45791406
30rRNA modification (GO:0000154)3.43443496
31telomere maintenance via telomerase (GO:0007004)3.41598015
32rRNA methylation (GO:0031167)3.38960733
33female gonad development (GO:0008585)3.38127269
34DNA replication checkpoint (GO:0000076)3.30500725
35lysine catabolic process (GO:0006554)3.26862368
36lysine metabolic process (GO:0006553)3.26862368
37oxidative phosphorylation (GO:0006119)3.20484142
38protein-cofactor linkage (GO:0018065)3.20466354
39negative regulation of telomerase activity (GO:0051974)3.18361819
40negative regulation of activin receptor signaling pathway (GO:0032926)3.18054307
41neurofilament cytoskeleton organization (GO:0060052)3.14825627
42fucose catabolic process (GO:0019317)3.13088248
43L-fucose metabolic process (GO:0042354)3.13088248
44L-fucose catabolic process (GO:0042355)3.13088248
45negative regulation of DNA recombination (GO:0045910)3.11329359
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08342918
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.08342918
48protein deneddylation (GO:0000338)3.05518462
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03112469
50protein complex biogenesis (GO:0070271)3.02748618
51negative regulation of membrane potential (GO:0045837)3.01878976
52mitochondrial respiratory chain complex assembly (GO:0033108)3.01092274
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99470340
54cytochrome complex assembly (GO:0017004)2.99433457
55DNA replication-dependent nucleosome assembly (GO:0006335)2.96611469
56DNA replication-dependent nucleosome organization (GO:0034723)2.96611469
57platelet dense granule organization (GO:0060155)2.96074875
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94331622
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.94331622
60NADH dehydrogenase complex assembly (GO:0010257)2.94331622
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90170182
62DNA replication-independent nucleosome organization (GO:0034724)2.86519733
63DNA replication-independent nucleosome assembly (GO:0006336)2.86519733
64presynaptic membrane assembly (GO:0097105)2.76571038
65nucleobase biosynthetic process (GO:0046112)2.74765512
66presynaptic membrane organization (GO:0097090)2.73177565
67regulation of nuclear cell cycle DNA replication (GO:0033262)2.72137383
68nonmotile primary cilium assembly (GO:0035058)2.64562588
69regulation of telomerase activity (GO:0051972)2.64117469
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61988496
71regulation of telomere maintenance (GO:0032204)2.61750981
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60003633
73establishment of integrated proviral latency (GO:0075713)2.58437202
74hydrogen ion transmembrane transport (GO:1902600)2.57177712
75tachykinin receptor signaling pathway (GO:0007217)2.54899899
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52874841
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52874841
78vocalization behavior (GO:0071625)2.52279694
79purine nucleobase biosynthetic process (GO:0009113)2.50192276
80ATP biosynthetic process (GO:0006754)2.48889408
81DNA catabolic process, exonucleolytic (GO:0000738)2.47126889
82otic vesicle formation (GO:0030916)2.47125186
83pseudouridine synthesis (GO:0001522)2.46416112
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.46358948
85L-serine metabolic process (GO:0006563)2.46318301
86RNA-dependent DNA replication (GO:0006278)2.46192413
87indolalkylamine metabolic process (GO:0006586)2.45043213
88serotonin receptor signaling pathway (GO:0007210)2.44667429
89replication fork processing (GO:0031297)2.43637959
90short-term memory (GO:0007614)2.41017336
91neural tube formation (GO:0001841)2.40418313
92purine nucleoside triphosphate biosynthetic process (GO:0009145)2.40015897
93ubiquinone biosynthetic process (GO:0006744)2.39845226
94transmission of nerve impulse (GO:0019226)2.39603792
95regulation of synapse structural plasticity (GO:0051823)2.39037942
96negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38809612
97spliceosomal snRNP assembly (GO:0000387)2.37774926
98mitochondrial RNA metabolic process (GO:0000959)2.36463573
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.35485122
100organelle disassembly (GO:1903008)2.34877260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85312123
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.41928756
3ZNF274_21170338_ChIP-Seq_K562_Hela3.38625589
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.30855750
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.87079251
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73546406
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69000735
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.66063178
9EZH2_22144423_ChIP-Seq_EOC_Human2.43730629
10FUS_26573619_Chip-Seq_HEK293_Human2.40073272
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29843767
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29162718
13EWS_26573619_Chip-Seq_HEK293_Human2.25247355
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.23782792
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.17733874
16MYC_18940864_ChIP-ChIP_HL60_Human2.16519815
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13245322
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.08118826
19VDR_22108803_ChIP-Seq_LS180_Human2.03789096
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98849833
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94674063
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94120523
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93962206
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90173399
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89489799
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86410801
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.84176304
28TAF15_26573619_Chip-Seq_HEK293_Human1.82398346
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81865875
30P300_19829295_ChIP-Seq_ESCs_Human1.81088287
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80245988
32ELK1_19687146_ChIP-ChIP_HELA_Human1.74825198
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74133287
34GBX2_23144817_ChIP-Seq_PC3_Human1.69898631
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68778827
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68434498
37VDR_23849224_ChIP-Seq_CD4+_Human1.60547384
38IRF1_19129219_ChIP-ChIP_H3396_Human1.54236918
39FOXP3_21729870_ChIP-Seq_TREG_Human1.49108412
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47244853
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.47018405
42NANOG_16153702_ChIP-ChIP_HESCs_Human1.45601094
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.43834145
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42538019
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40712874
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38970292
47RNF2_27304074_Chip-Seq_NSC_Mouse1.36159430
48E2F7_22180533_ChIP-Seq_HELA_Human1.32048344
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30730214
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30666266
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30320747
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.28713241
53ER_23166858_ChIP-Seq_MCF-7_Human1.28352450
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27872147
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26351447
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21445715
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21009923
58IGF1R_20145208_ChIP-Seq_DFB_Human1.20267739
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16756590
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.16266707
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16202618
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15491590
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13693862
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.12208613
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08084522
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06858521
67TCF4_22108803_ChIP-Seq_LS180_Human1.06220497
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05280847
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.05004290
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04061255
71REST_21632747_ChIP-Seq_MESCs_Mouse1.03718115
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.03529499
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03171761
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03171761
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.02505680
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02077838
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01955053
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01843814
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01843814
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01843814
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00852557
82HTT_18923047_ChIP-ChIP_STHdh_Human1.00746672
83BCAT_22108803_ChIP-Seq_LS180_Human0.99428142
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.99239340
85TTF2_22483619_ChIP-Seq_HELA_Human0.96821313
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96397934
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.96060839
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96026517
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.96026517
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95555172
91SOX2_19829295_ChIP-Seq_ESCs_Human0.95511425
92NANOG_19829295_ChIP-Seq_ESCs_Human0.95511425
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94944174
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94752424
95XRN2_22483619_ChIP-Seq_HELA_Human0.94717594
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93618432
97JUN_21703547_ChIP-Seq_K562_Human0.93546164
98CBP_20019798_ChIP-Seq_JUKART_Human0.92950724
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92950724
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90367588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.73243183
2MP0003787_abnormal_imprinting3.34860155
3MP0003136_yellow_coat_color3.19387514
4MP0004742_abnormal_vestibular_system2.99835319
5MP0008877_abnormal_DNA_methylation2.78211878
6MP0001485_abnormal_pinna_reflex2.54764054
7MP0006072_abnormal_retinal_apoptosis2.38321081
8MP0002653_abnormal_ependyma_morphology2.33585221
9MP0003890_abnormal_embryonic-extraembry2.33209956
10MP0008058_abnormal_DNA_repair2.22321617
11MP0006292_abnormal_olfactory_placode2.21166342
12MP0003693_abnormal_embryo_hatching2.20119919
13MP0003121_genomic_imprinting2.20090042
14MP0004885_abnormal_endolymph2.09800764
15MP0002938_white_spotting2.08425282
16MP0001293_anophthalmia2.02420687
17MP0002102_abnormal_ear_morphology2.01420116
18MP0004133_heterotaxia1.98485388
19MP0001486_abnormal_startle_reflex1.84833075
20MP0003718_maternal_effect1.84413675
21MP0010094_abnormal_chromosome_stability1.83114398
22MP0005187_abnormal_penis_morphology1.80464505
23MP0003122_maternal_imprinting1.79736757
24MP0003878_abnormal_ear_physiology1.78798160
25MP0005377_hearing/vestibular/ear_phenot1.78798160
26MP0003111_abnormal_nucleus_morphology1.66109154
27MP0006276_abnormal_autonomic_nervous1.63938193
28MP0003315_abnormal_perineum_morphology1.59890908
29MP0002736_abnormal_nociception_after1.57591390
30MP0004957_abnormal_blastocyst_morpholog1.57360303
31MP0001188_hyperpigmentation1.53622374
32MP0000372_irregular_coat_pigmentation1.50788343
33MP0003567_abnormal_fetal_cardiomyocyte1.49783873
34MP0002272_abnormal_nervous_system1.45528829
35MP0003119_abnormal_digestive_system1.42903250
36MP0000647_abnormal_sebaceous_gland1.42021819
37MP0003195_calcinosis1.36723510
38MP0004215_abnormal_myocardial_fiber1.35271490
39MP0003806_abnormal_nucleotide_metabolis1.34761950
40MP0004142_abnormal_muscle_tone1.30023893
41MP0009046_muscle_twitch1.28947935
42MP0002735_abnormal_chemical_nociception1.28757162
43MP0008932_abnormal_embryonic_tissue1.28418865
44MP0002638_abnormal_pupillary_reflex1.27026733
45MP0005551_abnormal_eye_electrophysiolog1.25815569
46MP0005253_abnormal_eye_physiology1.22074905
47MP0000537_abnormal_urethra_morphology1.21004211
48MP0009745_abnormal_behavioral_response1.19418751
49MP0004185_abnormal_adipocyte_glucose1.19093544
50MP0003646_muscle_fatigue1.19031591
51MP0005084_abnormal_gallbladder_morpholo1.17672678
52MP0002277_abnormal_respiratory_mucosa1.16818205
53MP0001905_abnormal_dopamine_level1.13918422
54MP0001286_abnormal_eye_development1.12184015
55MP0003937_abnormal_limbs/digits/tail_de1.11956521
56MP0008057_abnormal_DNA_replication1.08292703
57MP0002067_abnormal_sensory_capabilities1.07374015
58MP0005408_hypopigmentation1.04749151
59MP0000049_abnormal_middle_ear1.04077328
60MP0002752_abnormal_somatic_nervous1.03921723
61MP0002254_reproductive_system_inflammat1.02641778
62MP0002572_abnormal_emotion/affect_behav1.01578581
63MP0003635_abnormal_synaptic_transmissio1.01062596
64MP0008872_abnormal_physiological_respon1.00612647
65MP0002697_abnormal_eye_size1.00367163
66MP0002064_seizures0.98182699
67MP0002734_abnormal_mechanical_nocicepti0.98075363
68MP0010386_abnormal_urinary_bladder0.97405824
69MP0002751_abnormal_autonomic_nervous0.97268489
70MP0001529_abnormal_vocalization0.95651982
71MP0003011_delayed_dark_adaptation0.94645137
72MP0001963_abnormal_hearing_physiology0.93648717
73MP0005195_abnormal_posterior_eye0.91065180
74MP0002557_abnormal_social/conspecific_i0.89818113
75MP0003283_abnormal_digestive_organ0.89481768
76MP0002837_dystrophic_cardiac_calcinosis0.87214705
77MP0002184_abnormal_innervation0.87171709
78MP0003880_abnormal_central_pattern0.86073733
79MP0000579_abnormal_nail_morphology0.86072362
80MP0002063_abnormal_learning/memory/cond0.84878948
81MP0000026_abnormal_inner_ear0.84726034
82MP0005391_vision/eye_phenotype0.84710435
83MP0001984_abnormal_olfaction0.84706305
84MP0000955_abnormal_spinal_cord0.84501417
85MP0004019_abnormal_vitamin_homeostasis0.84383535
86MP0005386_behavior/neurological_phenoty0.83908402
87MP0004924_abnormal_behavior0.83908402
88MP0001970_abnormal_pain_threshold0.80876688
89MP0000631_abnormal_neuroendocrine_gland0.80507243
90MP0001968_abnormal_touch/_nociception0.80053664
91MP0004134_abnormal_chest_morphology0.79207926
92MP0002733_abnormal_thermal_nociception0.78584113
93MP0003861_abnormal_nervous_system0.78015639
94MP0004145_abnormal_muscle_electrophysio0.77989835
95MP0006036_abnormal_mitochondrial_physio0.75706562
96MP0003077_abnormal_cell_cycle0.75462360
97MP0001324_abnormal_eye_pigmentation0.73771320
98MP0001299_abnormal_eye_distance/0.72499167
99MP0002210_abnormal_sex_determination0.72082678
100MP0009672_abnormal_birth_weight0.71527991

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.24628768
2Colon cancer (HP:0003003)4.09747323
3Increased hepatocellular lipid droplets (HP:0006565)3.69230744
4Acute necrotizing encephalopathy (HP:0006965)3.66200130
5Acute encephalopathy (HP:0006846)3.63104112
6Mitochondrial inheritance (HP:0001427)3.55367075
7Lipid accumulation in hepatocytes (HP:0006561)3.27146651
8Abnormal mitochondria in muscle tissue (HP:0008316)3.21293313
9Hepatocellular necrosis (HP:0001404)3.16308526
10Birth length less than 3rd percentile (HP:0003561)3.13141875
11Increased CSF lactate (HP:0002490)3.10293029
12Abnormality of midbrain morphology (HP:0002418)3.02756018
13Molar tooth sign on MRI (HP:0002419)3.02756018
14Progressive macrocephaly (HP:0004481)2.96087442
15Limb dystonia (HP:0002451)2.88131930
16Septo-optic dysplasia (HP:0100842)2.85609529
17Hepatic necrosis (HP:0002605)2.65188180
18Esophageal atresia (HP:0002032)2.64856501
19True hermaphroditism (HP:0010459)2.59989508
20Abnormality of cochlea (HP:0000375)2.57550658
21Chronic hepatic failure (HP:0100626)2.57114825
22Congenital, generalized hypertrichosis (HP:0004540)2.55795201
23Renal Fanconi syndrome (HP:0001994)2.55169047
24Cerebral edema (HP:0002181)2.53933727
25Bilateral microphthalmos (HP:0007633)2.52531311
26Pancreatic cysts (HP:0001737)2.44122016
27Nephronophthisis (HP:0000090)2.41170322
28Methylmalonic acidemia (HP:0002912)2.38100652
29Pancreatic fibrosis (HP:0100732)2.32349505
30Myokymia (HP:0002411)2.29893129
31Abnormality of the ileum (HP:0001549)2.29250486
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27894877
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27894877
34Anencephaly (HP:0002323)2.27574158
35Meckel diverticulum (HP:0002245)2.27136340
36Abnormal number of erythroid precursors (HP:0012131)2.26800219
37Increased intramyocellular lipid droplets (HP:0012240)2.26662720
38Methylmalonic aciduria (HP:0012120)2.24930660
39Exertional dyspnea (HP:0002875)2.24036625
40Increased serum lactate (HP:0002151)2.21055761
41Gastrointestinal atresia (HP:0002589)2.18124641
42Oligodactyly (hands) (HP:0001180)2.14943552
43Abnormal respiratory motile cilium morphology (HP:0005938)2.13828362
44Abnormal respiratory epithelium morphology (HP:0012253)2.13828362
45Congenital stationary night blindness (HP:0007642)2.13368402
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10048299
47Hyperglycinemia (HP:0002154)2.09899485
48Intestinal atresia (HP:0011100)2.08184760
49Sclerocornea (HP:0000647)2.07453780
50Abnormal lung lobation (HP:0002101)2.07138903
51Hypogonadotrophic hypogonadism (HP:0000044)2.06917500
52Reticulocytopenia (HP:0001896)2.05072618
53Tinnitus (HP:0000360)2.04651553
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.02755732
55Poor suck (HP:0002033)2.02512317
56Anophthalmia (HP:0000528)1.99878971
57Abnormality of chromosome stability (HP:0003220)1.99132454
58Oral leukoplakia (HP:0002745)1.97882771
59Hyperglycinuria (HP:0003108)1.95099087
60Lactic acidosis (HP:0003128)1.94320050
61Leukodystrophy (HP:0002415)1.94024530
62Abnormality of serum amino acid levels (HP:0003112)1.93603019
63Breast aplasia (HP:0100783)1.93599775
64Absent septum pellucidum (HP:0001331)1.91936872
65Polyphagia (HP:0002591)1.90187087
66Morphological abnormality of the inner ear (HP:0011390)1.89841109
67Abnormality of renal resorption (HP:0011038)1.89302948
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.88549375
69Absent/shortened dynein arms (HP:0200106)1.88549375
70Abnormality of cells of the erythroid lineage (HP:0012130)1.88104893
71Lethargy (HP:0001254)1.87998442
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87310580
73Abolished electroretinogram (ERG) (HP:0000550)1.87280198
74Respiratory failure (HP:0002878)1.86814106
75Aplastic anemia (HP:0001915)1.86079819
76Neoplasm of the adrenal gland (HP:0100631)1.85920193
77Hypoplasia of the pons (HP:0012110)1.85651580
78Macrocytic anemia (HP:0001972)1.85057755
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84941281
80Abnormality of alanine metabolism (HP:0010916)1.84941281
81Hyperalaninemia (HP:0003348)1.84941281
82Abnormality of the preputium (HP:0100587)1.84842217
83Abnormal ciliary motility (HP:0012262)1.84372160
84Abnormality of the renal medulla (HP:0100957)1.84037936
85Hypothermia (HP:0002045)1.82912607
86Abnormality of the pons (HP:0007361)1.82897908
87Optic disc pallor (HP:0000543)1.82327488
88Triphalangeal thumb (HP:0001199)1.79395811
89Abnormality of glycine metabolism (HP:0010895)1.78212101
90Abnormality of serine family amino acid metabolism (HP:0010894)1.78212101
91Chronic bronchitis (HP:0004469)1.77938995
92Abnormal number of incisors (HP:0011064)1.75611331
93Maternal diabetes (HP:0009800)1.75163430
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74557388
95Abnormal protein N-linked glycosylation (HP:0012347)1.74557388
96Abnormal protein glycosylation (HP:0012346)1.74557388
97Abnormal glycosylation (HP:0012345)1.74557388
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74156130
99Neoplasm of the colon (HP:0100273)1.73938571
100Hypoplastic female external genitalia (HP:0012815)1.73856136

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.74441275
2BMPR1B3.57571016
3ACVR1B3.22227752
4MST43.16848446
5BUB13.09229588
6CAMK1D2.71831014
7CAMKK22.49333046
8TAF12.41290170
9GRK12.39643098
10ADRBK22.34356436
11CDC72.33065115
12TRIM282.18832415
13TSSK62.12384924
14WEE12.07825723
15NUAK12.03243035
16TXK2.00532824
17MKNK21.97067579
18CAMK1G1.97009009
19TNIK1.88214764
20ZAK1.84134143
21NEK11.80480085
22STK161.73725784
23MARK11.69391417
24PNCK1.69296253
25OXSR11.64511316
26VRK21.60224053
27DYRK21.59309568
28PLK41.54993528
29TGFBR11.53487018
30PLK31.50461559
31NLK1.38089119
32MKNK11.34220794
33MAP3K41.33512548
34TTK1.26677350
35WNK41.19611541
36PBK1.17003204
37TLK11.13145521
38MAP3K121.09373177
39SRPK11.09315461
40INSRR1.06021624
41VRK11.03890538
42PLK11.00778293
43PRKCG0.95860374
44MAP2K70.95534295
45GRK70.92038860
46STK240.91361060
47CSNK1G10.90473412
48SIK30.89124513
49MINK10.87929393
50MAPK130.84780645
51NME10.81646307
52STK390.77453289
53NEK20.77003395
54CDK30.74241843
55PLK20.72679183
56ATR0.71880890
57ALK0.70247873
58CASK0.69432278
59ADRBK10.68768885
60BRD40.65238232
61NTRK10.61759010
62CHEK20.61215760
63CSNK1G20.59670724
64BCR0.59136715
65PASK0.58088625
66CSNK1G30.52487909
67EIF2AK20.49915376
68DYRK30.47245571
69CAMK2A0.46271335
70CDK90.46112256
71TIE10.44197600
72STK30.42168179
73AURKB0.41971233
74BRSK10.40759123
75PAK30.40310018
76CAMK10.39695373
77MAP4K20.38515552
78PRKCE0.38124228
79ATM0.36975140
80RPS6KA50.36252997
81CSNK1E0.36043384
82PDK20.35950117
83CAMKK10.34945135
84CSNK2A10.34881494
85EPHA30.32943854
86MAPKAPK50.32615489
87STK38L0.31185705
88NTRK20.30988245
89PRKACA0.27097600
90CSNK2A20.27045235
91EPHA40.26848240
92DYRK1A0.26750761
93GRK50.26010134
94CSNK1A10.25171676
95PRKDC0.24952499
96MATK0.24380965
97UHMK10.24172746
98CSNK1A1L0.23768413
99PINK10.23226865
100MAP2K40.23093412

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.90637774
2Parkinsons disease_Homo sapiens_hsa050123.42062142
3RNA polymerase_Homo sapiens_hsa030203.32851855
4Proteasome_Homo sapiens_hsa030503.11409818
5Protein export_Homo sapiens_hsa030602.90544413
6Ribosome_Homo sapiens_hsa030102.59753217
7Mismatch repair_Homo sapiens_hsa034302.57878499
8Selenocompound metabolism_Homo sapiens_hsa004502.51289997
9Huntingtons disease_Homo sapiens_hsa050162.38063207
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26316219
11Alzheimers disease_Homo sapiens_hsa050102.19203715
12DNA replication_Homo sapiens_hsa030302.04205748
13Homologous recombination_Homo sapiens_hsa034401.89822063
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88959722
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.88944627
16Cardiac muscle contraction_Homo sapiens_hsa042601.76404758
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75887147
18Propanoate metabolism_Homo sapiens_hsa006401.74562735
19Fanconi anemia pathway_Homo sapiens_hsa034601.72758581
20Non-homologous end-joining_Homo sapiens_hsa034501.68150892
21Butanoate metabolism_Homo sapiens_hsa006501.60391377
22Basal transcription factors_Homo sapiens_hsa030221.57321331
23Base excision repair_Homo sapiens_hsa034101.51600934
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.45001429
25RNA degradation_Homo sapiens_hsa030181.44038849
26Nicotine addiction_Homo sapiens_hsa050331.41346437
27Tryptophan metabolism_Homo sapiens_hsa003801.37464985
28Spliceosome_Homo sapiens_hsa030401.33742205
29Pyrimidine metabolism_Homo sapiens_hsa002401.32153466
30Phototransduction_Homo sapiens_hsa047441.30768109
31Sulfur relay system_Homo sapiens_hsa041221.30244753
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26967906
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23368321
34One carbon pool by folate_Homo sapiens_hsa006701.22393871
35Nucleotide excision repair_Homo sapiens_hsa034201.18771844
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16923031
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15960445
38Pyruvate metabolism_Homo sapiens_hsa006201.15352375
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13685789
40RNA transport_Homo sapiens_hsa030131.10551303
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09669068
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07878304
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05891995
44Purine metabolism_Homo sapiens_hsa002301.03830841
45Vitamin digestion and absorption_Homo sapiens_hsa049771.00954290
46Cell cycle_Homo sapiens_hsa041100.99853763
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98737340
48Fatty acid elongation_Homo sapiens_hsa000620.97760499
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96503261
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92822847
51Taste transduction_Homo sapiens_hsa047420.89715547
52Steroid biosynthesis_Homo sapiens_hsa001000.89330405
53Glutathione metabolism_Homo sapiens_hsa004800.89222159
54Vitamin B6 metabolism_Homo sapiens_hsa007500.89098897
55Linoleic acid metabolism_Homo sapiens_hsa005910.87921484
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82619199
57Chemical carcinogenesis_Homo sapiens_hsa052040.81488580
58Caffeine metabolism_Homo sapiens_hsa002320.79808905
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76649964
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75950772
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73642297
62Metabolic pathways_Homo sapiens_hsa011000.73136078
63Morphine addiction_Homo sapiens_hsa050320.72031237
64Peroxisome_Homo sapiens_hsa041460.71599813
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69061567
66Retinol metabolism_Homo sapiens_hsa008300.68430261
67Serotonergic synapse_Homo sapiens_hsa047260.65343385
68Hedgehog signaling pathway_Homo sapiens_hsa043400.64890321
69Collecting duct acid secretion_Homo sapiens_hsa049660.64595603
70beta-Alanine metabolism_Homo sapiens_hsa004100.63851669
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.62133972
72GABAergic synapse_Homo sapiens_hsa047270.59126509
73Nitrogen metabolism_Homo sapiens_hsa009100.57829765
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55372447
75Basal cell carcinoma_Homo sapiens_hsa052170.54225138
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52366921
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50875056
78Tyrosine metabolism_Homo sapiens_hsa003500.49631422
79Fat digestion and absorption_Homo sapiens_hsa049750.49548005
80Glutamatergic synapse_Homo sapiens_hsa047240.48748219
81Histidine metabolism_Homo sapiens_hsa003400.46906272
82Olfactory transduction_Homo sapiens_hsa047400.46495895
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44665963
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43787187
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41683077
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.41490727
87Oocyte meiosis_Homo sapiens_hsa041140.38978656
88Fatty acid degradation_Homo sapiens_hsa000710.38954717
89Circadian entrainment_Homo sapiens_hsa047130.38306925
90TGF-beta signaling pathway_Homo sapiens_hsa043500.35922899
91Biosynthesis of amino acids_Homo sapiens_hsa012300.32505988
92Carbon metabolism_Homo sapiens_hsa012000.32295384
93Cocaine addiction_Homo sapiens_hsa050300.31290167
94Dopaminergic synapse_Homo sapiens_hsa047280.30105982
95mRNA surveillance pathway_Homo sapiens_hsa030150.29669034
96Amphetamine addiction_Homo sapiens_hsa050310.29100351
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25555599
98Arachidonic acid metabolism_Homo sapiens_hsa005900.22862182
99Wnt signaling pathway_Homo sapiens_hsa043100.22243949
100Ether lipid metabolism_Homo sapiens_hsa005650.21860349

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