TERF1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.57340911
2DNA double-strand break processing (GO:0000729)5.32770214
3protein neddylation (GO:0045116)5.15396781
4chaperone-mediated protein transport (GO:0072321)5.10033970
5DNA strand renaturation (GO:0000733)4.81708773
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.65977787
7ATP synthesis coupled proton transport (GO:0015986)4.64427271
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.64427271
9chromatin remodeling at centromere (GO:0031055)4.58258342
10DNA replication checkpoint (GO:0000076)4.32994014
11regulation of double-strand break repair via homologous recombination (GO:0010569)4.29742099
12respiratory electron transport chain (GO:0022904)4.29443684
13electron transport chain (GO:0022900)4.16985081
14signal peptide processing (GO:0006465)4.12235331
15DNA deamination (GO:0045006)4.11279215
16pseudouridine synthesis (GO:0001522)4.11153746
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.02324319
18CENP-A containing nucleosome assembly (GO:0034080)3.94764867
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.92956519
20cullin deneddylation (GO:0010388)3.92571991
21DNA catabolic process, exonucleolytic (GO:0000738)3.86789908
22histone mRNA metabolic process (GO:0008334)3.85718754
23respiratory chain complex IV assembly (GO:0008535)3.85613754
24fatty acid elongation (GO:0030497)3.83974428
25proteasome assembly (GO:0043248)3.83657883
26protein complex biogenesis (GO:0070271)3.78459046
27termination of RNA polymerase III transcription (GO:0006386)3.75671619
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.75671619
29mitochondrial respiratory chain complex assembly (GO:0033108)3.72666940
30cytochrome complex assembly (GO:0017004)3.63655678
31DNA damage response, detection of DNA damage (GO:0042769)3.63000361
32mismatch repair (GO:0006298)3.62439649
33meiotic chromosome segregation (GO:0045132)3.52305242
34rRNA modification (GO:0000154)3.51022785
35histone exchange (GO:0043486)3.50537454
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49798079
37transcription from mitochondrial promoter (GO:0006390)3.47738364
38protein deneddylation (GO:0000338)3.45725162
39regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41713559
40regulation of mitotic spindle checkpoint (GO:1903504)3.41713559
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.39179826
42NADH dehydrogenase complex assembly (GO:0010257)3.39179826
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39179826
44pteridine-containing compound biosynthetic process (GO:0042559)3.38390080
45regulation of mitochondrial translation (GO:0070129)3.33731603
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.29991498
47nucleobase biosynthetic process (GO:0046112)3.26941531
48purine nucleobase biosynthetic process (GO:0009113)3.25935582
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.25413238
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25413238
51replication fork processing (GO:0031297)3.24033682
52mitochondrial RNA metabolic process (GO:0000959)3.18841504
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15646891
54negative regulation of ligase activity (GO:0051352)3.15646891
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15587512
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.14918405
57cytidine deamination (GO:0009972)3.13983595
58cytidine metabolic process (GO:0046087)3.13983595
59cytidine catabolic process (GO:0006216)3.13983595
60spliceosomal snRNP assembly (GO:0000387)3.02880518
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99837672
62double-strand break repair via homologous recombination (GO:0000724)2.97892778
63positive regulation of mRNA processing (GO:0050685)2.96039358
64recombinational repair (GO:0000725)2.95919046
65ubiquinone biosynthetic process (GO:0006744)2.95253439
66histone H2A acetylation (GO:0043968)2.89515757
67regulation of cellular amino acid metabolic process (GO:0006521)2.89056134
68regulation of translational termination (GO:0006449)2.86542954
69protein K6-linked ubiquitination (GO:0085020)2.84899987
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83361274
71behavioral response to nicotine (GO:0035095)2.82557462
72water-soluble vitamin biosynthetic process (GO:0042364)2.81972646
73hydrogen ion transmembrane transport (GO:1902600)2.81678156
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80250930
75positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.79279954
76regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.79279954
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78162712
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78162712
79signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78162712
80adenosine metabolic process (GO:0046085)2.76491015
81intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74874470
82signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74874470
83rRNA processing (GO:0006364)2.74165784
84ubiquinone metabolic process (GO:0006743)2.72211820
85regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71204163
86rRNA methylation (GO:0031167)2.70453032
87platelet dense granule organization (GO:0060155)2.69472069
88DNA-templated transcription, termination (GO:0006353)2.69453046
89termination of RNA polymerase II transcription (GO:0006369)2.67453501
90IMP biosynthetic process (GO:0006188)2.67249102
917-methylguanosine mRNA capping (GO:0006370)2.67095818
92pre-miRNA processing (GO:0031054)2.66059423
93DNA replication-independent nucleosome assembly (GO:0006336)2.65767725
94DNA replication-independent nucleosome organization (GO:0034724)2.65767725
95regulation of helicase activity (GO:0051095)2.65168015
96tricarboxylic acid cycle (GO:0006099)2.65105577
97ribosome assembly (GO:0042255)2.64159316
98rRNA metabolic process (GO:0016072)2.64138027
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.63823758
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63219221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.41492531
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.61887210
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.05324965
4E2F7_22180533_ChIP-Seq_HELA_Human3.93646642
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.86767592
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34152225
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20777335
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89181298
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86279259
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84539638
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76224964
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72100174
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69220900
14ELK1_19687146_ChIP-ChIP_HELA_Human2.56551081
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.55700616
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.36404796
17VDR_23849224_ChIP-Seq_CD4+_Human2.21822917
18IGF1R_20145208_ChIP-Seq_DFB_Human2.21045436
19FOXP3_21729870_ChIP-Seq_TREG_Human1.99572775
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98441468
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.95322308
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95171245
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.89385092
24PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78904951
25FUS_26573619_Chip-Seq_HEK293_Human1.78730510
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78545104
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72285214
28EWS_26573619_Chip-Seq_HEK293_Human1.71481305
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63049123
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61686297
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58961425
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.57989603
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57107075
34VDR_22108803_ChIP-Seq_LS180_Human1.55273998
35MYC_18940864_ChIP-ChIP_HL60_Human1.49036524
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47597248
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40443140
38P300_19829295_ChIP-Seq_ESCs_Human1.37679725
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37560568
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35664435
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35352031
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33782916
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33477733
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.30893384
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30082170
46NANOG_16153702_ChIP-ChIP_HESCs_Human1.28089548
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27820936
48ZNF274_21170338_ChIP-Seq_K562_Hela1.27644247
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25854636
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25707186
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21558320
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.21558320
53SOX2_16153702_ChIP-ChIP_HESCs_Human1.19172970
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19100183
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18962984
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16810064
57BCAT_22108803_ChIP-Seq_LS180_Human1.16434783
58DCP1A_22483619_ChIP-Seq_HELA_Human1.14323450
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13307855
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.12710164
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.10143921
62TAF15_26573619_Chip-Seq_HEK293_Human1.09558659
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08890536
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08767189
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08613443
66GABP_19822575_ChIP-Seq_HepG2_Human1.08042157
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07616105
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06975812
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06770741
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06576153
71TTF2_22483619_ChIP-Seq_HELA_Human1.06526588
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05432684
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04525312
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.04460602
75TP53_22573176_ChIP-Seq_HFKS_Human1.02544325
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02111902
77AR_21909140_ChIP-Seq_LNCAP_Human1.00532008
78NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99837196
79CBP_20019798_ChIP-Seq_JUKART_Human0.99317971
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99317971
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98821940
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98801814
83NOTCH1_21737748_ChIP-Seq_TLL_Human0.97619293
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96094305
85AR_20517297_ChIP-Seq_VCAP_Human0.95862564
86NANOG_19829295_ChIP-Seq_ESCs_Human0.95583937
87SOX2_19829295_ChIP-Seq_ESCs_Human0.95583937
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94502854
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93340506
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93166757
91MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93025170
92XRN2_22483619_ChIP-Seq_HELA_Human0.92934376
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91844826
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.91292283
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.91192570
96HOXB7_26014856_ChIP-Seq_BT474_Human0.90345849
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87226907
98TCF4_22108803_ChIP-Seq_LS180_Human0.84735596
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.84205301
100RBPJ_21746931_ChIP-Seq_IB4_Human0.81880493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.18063086
2MP0001188_hyperpigmentation4.02716197
3MP0003693_abnormal_embryo_hatching3.81302893
4MP0004957_abnormal_blastocyst_morpholog3.01675738
5MP0006072_abnormal_retinal_apoptosis2.93000724
6MP0008877_abnormal_DNA_methylation2.75051251
7MP0006292_abnormal_olfactory_placode2.74022580
8MP0009697_abnormal_copulation2.64070506
9MP0005423_abnormal_somatic_nervous2.56861152
10MP0000579_abnormal_nail_morphology2.56566511
11MP0003880_abnormal_central_pattern2.54598865
12MP0003123_paternal_imprinting2.33109970
13MP0003111_abnormal_nucleus_morphology2.23242463
14MP0004043_abnormal_pH_regulation2.18561665
15MP0005551_abnormal_eye_electrophysiolog2.13628565
16MP0008007_abnormal_cellular_replicative2.05930089
17MP0003786_premature_aging2.05064955
18MP0008932_abnormal_embryonic_tissue1.96652138
19MP0008058_abnormal_DNA_repair1.95161813
20MP0003195_calcinosis1.91792598
21MP0002090_abnormal_vision1.91316130
22MP0005253_abnormal_eye_physiology1.87934695
23MP0003787_abnormal_imprinting1.81763342
24MP0003121_genomic_imprinting1.81622972
25MP0001984_abnormal_olfaction1.77538369
26MP0006035_abnormal_mitochondrial_morpho1.77445203
27MP0010094_abnormal_chromosome_stability1.73598490
28MP0003136_yellow_coat_color1.70753846
29MP0002736_abnormal_nociception_after1.70750549
30MP0002254_reproductive_system_inflammat1.70271931
31MP0004133_heterotaxia1.68671309
32MP0001661_extended_life_span1.64361225
33MP0000647_abnormal_sebaceous_gland1.62093702
34MP0001968_abnormal_touch/_nociception1.52113910
35MP0003718_maternal_effect1.49382572
36MP0008057_abnormal_DNA_replication1.46609873
37MP0003806_abnormal_nucleotide_metabolis1.40811681
38MP0008872_abnormal_physiological_respon1.38429775
39MP0002734_abnormal_mechanical_nocicepti1.37416821
40MP0001529_abnormal_vocalization1.30919422
41MP0002102_abnormal_ear_morphology1.29230304
42MP0006036_abnormal_mitochondrial_physio1.25954396
43MP0005332_abnormal_amino_acid1.21568603
44MP0001485_abnormal_pinna_reflex1.21101034
45MP0002837_dystrophic_cardiac_calcinosis1.19404268
46MP0003646_muscle_fatigue1.19401844
47MP0001177_atelectasis1.19264233
48MP0003077_abnormal_cell_cycle1.12174913
49MP0009745_abnormal_behavioral_response1.09646860
50MP0001293_anophthalmia1.08817101
51MP0006276_abnormal_autonomic_nervous1.08802978
52MP0003011_delayed_dark_adaptation1.07957867
53MP0004215_abnormal_myocardial_fiber1.01578689
54MP0001764_abnormal_homeostasis1.01266810
55MP0002735_abnormal_chemical_nociception1.00954846
56MP0000631_abnormal_neuroendocrine_gland1.00903564
57MP0003950_abnormal_plasma_membrane0.94565996
58MP0005410_abnormal_fertilization0.92773230
59MP0003119_abnormal_digestive_system0.90323681
60MP0001986_abnormal_taste_sensitivity0.89905396
61MP0002751_abnormal_autonomic_nervous0.89835032
62MP0003122_maternal_imprinting0.89365533
63MP0009379_abnormal_foot_pigmentation0.88181541
64MP0008789_abnormal_olfactory_epithelium0.87945341
65MP0003283_abnormal_digestive_organ0.83166896
66MP0009672_abnormal_birth_weight0.83087021
67MP0003186_abnormal_redox_activity0.81591879
68MP0001970_abnormal_pain_threshold0.80209698
69MP0002160_abnormal_reproductive_system0.78936551
70MP0002638_abnormal_pupillary_reflex0.78695608
71MP0002938_white_spotting0.78466025
72MP0005389_reproductive_system_phenotype0.77773683
73MP0005084_abnormal_gallbladder_morpholo0.77754025
74MP0001905_abnormal_dopamine_level0.77658523
75MP0004142_abnormal_muscle_tone0.76998217
76MP0005391_vision/eye_phenotype0.74603893
77MP0005671_abnormal_response_to0.74075929
78MP0002272_abnormal_nervous_system0.73064202
79MP0009785_altered_susceptibility_to0.71411810
80MP0002693_abnormal_pancreas_physiology0.69639276
81MP0005367_renal/urinary_system_phenotyp0.69109666
82MP0000516_abnormal_urinary_system0.69109666
83MP0002752_abnormal_somatic_nervous0.69031410
84MP0000383_abnormal_hair_follicle0.67882698
85MP0000467_abnormal_esophagus_morphology0.67669053
86MP0002229_neurodegeneration0.67570860
87MP0001486_abnormal_startle_reflex0.66101480
88MP0001929_abnormal_gametogenesis0.63038543
89MP0005195_abnormal_posterior_eye0.62843576
90MP0005395_other_phenotype0.61423994
91MP0005636_abnormal_mineral_homeostasis0.60398192
92MP0008875_abnormal_xenobiotic_pharmacok0.60179283
93MP0001853_heart_inflammation0.59641562
94MP0000538_abnormal_urinary_bladder0.59168867
95MP0009764_decreased_sensitivity_to0.58830824
96MP0004019_abnormal_vitamin_homeostasis0.58226153
97MP0001919_abnormal_reproductive_system0.57992450
98MP0003448_altered_tumor_morphology0.57967016
99MP0000427_abnormal_hair_cycle0.57914119
100MP0003137_abnormal_impulse_conducting0.57297827

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.56833543
2Hepatocellular necrosis (HP:0001404)4.43278524
3Congenital, generalized hypertrichosis (HP:0004540)4.36056292
4Acute encephalopathy (HP:0006846)4.33420757
5Mitochondrial inheritance (HP:0001427)4.27679647
6Abnormal mitochondria in muscle tissue (HP:0008316)4.14225465
7Hepatic necrosis (HP:0002605)3.93369149
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.80642498
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.80642498
10Increased CSF lactate (HP:0002490)3.80045138
11Methylmalonic acidemia (HP:0002912)3.78698143
12Progressive macrocephaly (HP:0004481)3.74237159
13Increased hepatocellular lipid droplets (HP:0006565)3.60740927
14Cerebral edema (HP:0002181)3.39287473
15Abnormality of the labia minora (HP:0012880)3.22768736
16Birth length less than 3rd percentile (HP:0003561)3.21782700
17Methylmalonic aciduria (HP:0012120)3.13172733
18Renal Fanconi syndrome (HP:0001994)3.00573295
19Abnormality of the vocal cords (HP:0008777)2.97183246
20Lipid accumulation in hepatocytes (HP:0006561)2.95206581
21Colon cancer (HP:0003003)2.91835791
22Congenital stationary night blindness (HP:0007642)2.75580249
23Respiratory failure (HP:0002878)2.74565159
24Respiratory difficulties (HP:0002880)2.70812116
25Cerebral hypomyelination (HP:0006808)2.70639444
26Lactic acidosis (HP:0003128)2.69495822
27CNS demyelination (HP:0007305)2.69084529
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65846975
29Decreased central vision (HP:0007663)2.54278921
30Exertional dyspnea (HP:0002875)2.50653417
31Increased serum lactate (HP:0002151)2.48350078
32Facial diplegia (HP:0001349)2.47662190
33Lethargy (HP:0001254)2.44631285
34True hermaphroditism (HP:0010459)2.43853581
35Leukodystrophy (HP:0002415)2.37312702
36Increased intramyocellular lipid droplets (HP:0012240)2.37000915
37Abnormality of methionine metabolism (HP:0010901)2.36371242
38Nephronophthisis (HP:0000090)2.35845507
39Abnormality of serum amino acid levels (HP:0003112)2.35112242
40Severe combined immunodeficiency (HP:0004430)2.34748466
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33946735
42Abnormal hair whorl (HP:0010721)2.32231908
43Molar tooth sign on MRI (HP:0002419)2.25903657
44Abnormality of midbrain morphology (HP:0002418)2.25903657
45Sparse eyelashes (HP:0000653)2.25029688
46Pancreatic fibrosis (HP:0100732)2.24787055
47CNS hypomyelination (HP:0003429)2.24782741
48Abnormality of vitamin B metabolism (HP:0004340)2.24060561
49Pili torti (HP:0003777)2.21916870
50Abnormal number of erythroid precursors (HP:0012131)2.18419972
51Abnormality of alanine metabolism (HP:0010916)2.17915949
52Hyperalaninemia (HP:0003348)2.17915949
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17915949
54Pancreatic islet-cell hyperplasia (HP:0004510)2.16598687
55Abnormality of the vitamin B12 metabolism (HP:0004341)2.16529320
56Hyperglycinemia (HP:0002154)2.13760324
57Megaloblastic anemia (HP:0001889)2.12247266
58Exercise intolerance (HP:0003546)2.10551079
59Oral leukoplakia (HP:0002745)2.09308579
60Myokymia (HP:0002411)2.08763860
61Septo-optic dysplasia (HP:0100842)2.06608201
62Hypoplasia of the pons (HP:0012110)2.05074118
63Pancreatic cysts (HP:0001737)2.03666213
64Optic disc pallor (HP:0000543)2.03023073
65Progressive inability to walk (HP:0002505)2.02406380
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99176997
67Cellular immunodeficiency (HP:0005374)1.97906649
68Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96192540
69Hypoproteinemia (HP:0003075)1.95912469
70Combined immunodeficiency (HP:0005387)1.95537648
71Abnormal lung lobation (HP:0002101)1.93461971
72Supernumerary spleens (HP:0009799)1.92612188
73Abnormality of serine family amino acid metabolism (HP:0010894)1.91947970
74Abnormality of glycine metabolism (HP:0010895)1.91947970
75Rough bone trabeculation (HP:0100670)1.91803698
76Abolished electroretinogram (ERG) (HP:0000550)1.90787832
77Abnormality of the pons (HP:0007361)1.90606233
78Carpal bone hypoplasia (HP:0001498)1.88407134
79Stenosis of the external auditory canal (HP:0000402)1.87939184
80IgG deficiency (HP:0004315)1.86451568
81Emotional lability (HP:0000712)1.86425698
82Pendular nystagmus (HP:0012043)1.83183255
83Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82158927
84Stomatitis (HP:0010280)1.80956779
85Microvesicular hepatic steatosis (HP:0001414)1.80415854
86Macrocytic anemia (HP:0001972)1.78853078
87Hyperinsulinemic hypoglycemia (HP:0000825)1.77360107
88Thyroid-stimulating hormone excess (HP:0002925)1.76875934
89Abnormality of cells of the erythroid lineage (HP:0012130)1.76453645
90X-linked dominant inheritance (HP:0001423)1.75361653
91Hip dysplasia (HP:0001385)1.75065513
92Panhypogammaglobulinemia (HP:0003139)1.74964388
93Abnormality of renal resorption (HP:0011038)1.73764881
94Chronic bronchitis (HP:0004469)1.73495297
95Abnormality of the middle phalanges of the toes (HP:0010183)1.73133993
96Abnormality of the renal medulla (HP:0100957)1.72789718
97Aplasia/Hypoplasia involving the musculature (HP:0001460)1.71877972
98IgM deficiency (HP:0002850)1.70517626
99Hyperglycinuria (HP:0003108)1.69347793
100Absent septum pellucidum (HP:0001331)1.69038206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK27.61276473
2VRK24.34895711
3NUAK13.70654614
4CDC73.65796603
5LATS12.85530540
6BUB12.55543341
7MKNK22.32322609
8MST42.17845905
9BMPR1B2.10418077
10TNIK1.92952195
11NEK61.92527003
12PLK41.91227467
13MKNK11.78813318
14VRK11.76895451
15BCKDK1.72328758
16GRK11.68656121
17STK161.67848725
18NME11.65662956
19PBK1.64513349
20ZAK1.62830549
21TTK1.60941292
22TAF11.59012705
23WNK31.58006906
24AKT31.48823723
25PLK31.42856148
26MAP4K21.39965425
27KDR1.39534653
28FRK1.39180409
29TSSK61.29811010
30EIF2AK31.29453541
31ADRBK21.19005120
32PIK3CA1.18133641
33TRIM281.17665613
34PLK11.14108630
35SRPK11.10920619
36NEK11.10284059
37NTRK21.06726479
38STK30.97030189
39IRAK20.93252639
40TLK10.89365568
41BRAF0.76064113
42PRKCG0.73445891
43TIE10.71698936
44BRSK20.67742325
45CSNK1G10.65755640
46OXSR10.63027693
47DYRK20.61644771
48IRAK10.61408119
49PLK20.60987014
50INSRR0.55071391
51MAPK130.54245881
52CSNK2A20.54216387
53ATR0.53215466
54STK40.51672131
55GRK70.49001819
56TXK0.46941589
57MAP3K40.45943359
58CSNK2A10.44504574
59MAP4K10.44052310
60RPS6KA40.43961269
61LIMK10.43332214
62MAPK70.43327100
63PHKG10.43201058
64PHKG20.43201058
65ATM0.43033920
66DAPK10.42827719
67EIF2AK10.42600972
68CSNK1E0.42440270
69AURKB0.41809370
70DYRK30.41626413
71PRKCE0.41268155
72BRD40.40444272
73MAPKAPK50.39624283
74PASK0.39571893
75ACVR1B0.39226206
76ALK0.37881250
77NLK0.37479891
78CLK10.36619063
79PTK2B0.35855268
80CDK80.35442296
81CAMK2G0.35147594
82PRKACA0.34078271
83CHEK20.33215361
84PRKCI0.32793354
85CDK30.31769532
86CSNK1G20.30469732
87CDK70.30217005
88PIM20.29945565
89EIF2AK20.29943200
90NEK20.29525106
91WEE10.26850156
92BRSK10.26778002
93TEC0.26655902
94CAMK2A0.26436594
95CSNK1A10.25310029
96PRKCA0.25085326
97RPS6KA50.24776937
98TESK20.24208310
99PRKCQ0.23788115
100AURKA0.23497524

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.95322452
2Oxidative phosphorylation_Homo sapiens_hsa001903.64324224
3RNA polymerase_Homo sapiens_hsa030203.52202741
4Parkinsons disease_Homo sapiens_hsa050123.13934276
5Mismatch repair_Homo sapiens_hsa034303.00960448
6Fatty acid elongation_Homo sapiens_hsa000622.69903874
7Propanoate metabolism_Homo sapiens_hsa006402.64316503
8Homologous recombination_Homo sapiens_hsa034402.58509042
9Protein export_Homo sapiens_hsa030602.57104321
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44237477
11Huntingtons disease_Homo sapiens_hsa050162.25039749
12DNA replication_Homo sapiens_hsa030302.18677233
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07668590
14Alzheimers disease_Homo sapiens_hsa050102.03171294
15Ribosome_Homo sapiens_hsa030101.97426806
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97022758
17Primary immunodeficiency_Homo sapiens_hsa053401.94772940
18Spliceosome_Homo sapiens_hsa030401.91972944
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87773218
20RNA degradation_Homo sapiens_hsa030181.78248609
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71727347
22Cardiac muscle contraction_Homo sapiens_hsa042601.69349626
23Nucleotide excision repair_Homo sapiens_hsa034201.67146106
24Basal transcription factors_Homo sapiens_hsa030221.62657291
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.55186718
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50862667
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43049791
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38475354
29RNA transport_Homo sapiens_hsa030131.36555523
30Fanconi anemia pathway_Homo sapiens_hsa034601.34208388
31Purine metabolism_Homo sapiens_hsa002301.33795305
32Pyrimidine metabolism_Homo sapiens_hsa002401.32230037
33One carbon pool by folate_Homo sapiens_hsa006701.27811060
34Pyruvate metabolism_Homo sapiens_hsa006201.21069992
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20356991
36Caffeine metabolism_Homo sapiens_hsa002321.15106873
37Butanoate metabolism_Homo sapiens_hsa006501.10178545
38Base excision repair_Homo sapiens_hsa034101.07352868
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06865546
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05168603
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03245367
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02437631
43Tryptophan metabolism_Homo sapiens_hsa003800.95703648
44Phototransduction_Homo sapiens_hsa047440.93884829
45Nitrogen metabolism_Homo sapiens_hsa009100.92674839
46Vitamin digestion and absorption_Homo sapiens_hsa049770.89450215
47beta-Alanine metabolism_Homo sapiens_hsa004100.89043472
48Selenocompound metabolism_Homo sapiens_hsa004500.88960017
49Folate biosynthesis_Homo sapiens_hsa007900.87854613
50Cell cycle_Homo sapiens_hsa041100.87226244
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86640700
52Chemical carcinogenesis_Homo sapiens_hsa052040.86017825
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84405189
54Non-homologous end-joining_Homo sapiens_hsa034500.82749595
55Renin-angiotensin system_Homo sapiens_hsa046140.79871976
56Glutathione metabolism_Homo sapiens_hsa004800.76472783
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76314775
58Peroxisome_Homo sapiens_hsa041460.75674043
59Metabolic pathways_Homo sapiens_hsa011000.75310026
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73530875
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72181707
62Fatty acid metabolism_Homo sapiens_hsa012120.70690614
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68412096
64Carbon metabolism_Homo sapiens_hsa012000.68138505
65Retinol metabolism_Homo sapiens_hsa008300.66862619
66Fatty acid degradation_Homo sapiens_hsa000710.66205322
67mRNA surveillance pathway_Homo sapiens_hsa030150.66023767
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65373548
69Nicotine addiction_Homo sapiens_hsa050330.64201679
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60598554
71Collecting duct acid secretion_Homo sapiens_hsa049660.60566337
72Sulfur relay system_Homo sapiens_hsa041220.56140225
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54895872
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52354311
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.51032151
76Oocyte meiosis_Homo sapiens_hsa041140.49131246
77Linoleic acid metabolism_Homo sapiens_hsa005910.48942936
78Regulation of autophagy_Homo sapiens_hsa041400.45663631
79Olfactory transduction_Homo sapiens_hsa047400.43992352
80Steroid biosynthesis_Homo sapiens_hsa001000.41971095
81Biosynthesis of amino acids_Homo sapiens_hsa012300.41307434
82Ether lipid metabolism_Homo sapiens_hsa005650.39128601
83Lysine degradation_Homo sapiens_hsa003100.37128921
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.36532730
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32521575
86ABC transporters_Homo sapiens_hsa020100.30340033
87Taste transduction_Homo sapiens_hsa047420.28064211
88Mineral absorption_Homo sapiens_hsa049780.26828898
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25456068
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23175013
91Vitamin B6 metabolism_Homo sapiens_hsa007500.22781010
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21959848
93Arachidonic acid metabolism_Homo sapiens_hsa005900.18100045
94Tyrosine metabolism_Homo sapiens_hsa003500.17490722
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16271221
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15952836
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15825661
98Starch and sucrose metabolism_Homo sapiens_hsa005000.14796096
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.13496120
100Hematopoietic cell lineage_Homo sapiens_hsa046400.12734781

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