TERF1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)7.06766523
2cytidine catabolic process (GO:0006216)7.06766523
3cytidine deamination (GO:0009972)7.06766523
4DNA deamination (GO:0045006)6.96013659
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.99581904
6establishment of protein localization to mitochondrial membrane (GO:0090151)5.74894731
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.49427749
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.46758854
9proteasome assembly (GO:0043248)5.42808664
10protein neddylation (GO:0045116)5.33673283
11chaperone-mediated protein transport (GO:0072321)5.03445149
12ATP synthesis coupled proton transport (GO:0015986)4.82481241
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.82481241
14chromatin remodeling at centromere (GO:0031055)4.28481951
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23259240
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.18416827
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.16623392
18transcription elongation from RNA polymerase III promoter (GO:0006385)4.15138336
19termination of RNA polymerase III transcription (GO:0006386)4.15138336
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.09547833
21CENP-A containing nucleosome assembly (GO:0034080)4.07736059
22respiratory electron transport chain (GO:0022904)4.04254694
23negative regulation of T cell apoptotic process (GO:0070233)4.03488463
24sequestering of actin monomers (GO:0042989)4.00801420
25electron transport chain (GO:0022900)3.98162681
26cullin deneddylation (GO:0010388)3.95752275
27cytolysis (GO:0019835)3.88278490
28protein deneddylation (GO:0000338)3.86620742
29negative regulation of ligase activity (GO:0051352)3.82119777
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.82119777
31ribosome assembly (GO:0042255)3.80197829
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.74818315
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.74818315
34DNA double-strand break processing (GO:0000729)3.74777155
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66455215
36pseudouridine synthesis (GO:0001522)3.60576688
37respiratory chain complex IV assembly (GO:0008535)3.60116677
38water-soluble vitamin biosynthetic process (GO:0042364)3.57610313
39histone exchange (GO:0043486)3.56920006
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55367567
41metallo-sulfur cluster assembly (GO:0031163)3.54687268
42iron-sulfur cluster assembly (GO:0016226)3.54687268
43histone mRNA metabolic process (GO:0008334)3.49639315
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.31310623
45regulation of cellular amino acid metabolic process (GO:0006521)3.30739635
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25541579
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.16338159
48cytochrome complex assembly (GO:0017004)3.14993712
49regulation of mitotic spindle checkpoint (GO:1903504)3.14105621
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.14105621
51protein targeting to mitochondrion (GO:0006626)3.11505081
52positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09792378
53DNA demethylation (GO:0080111)3.08062767
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07906830
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07906830
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07906830
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07378738
58rRNA modification (GO:0000154)3.04363946
59negative regulation of sister chromatid segregation (GO:0033046)3.03977094
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03977094
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03977094
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03977094
63negative regulation of mitotic sister chromatid separation (GO:2000816)3.03977094
64eosinophil chemotaxis (GO:0048245)3.03180920
65positive T cell selection (GO:0043368)3.01596240
66negative regulation by host of viral transcription (GO:0043922)3.01317096
67establishment of protein localization to mitochondrion (GO:0072655)3.00891276
68protein K11-linked ubiquitination (GO:0070979)2.99803278
69transcription from mitochondrial promoter (GO:0006390)2.99386603
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98159383
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98159383
72maturation of 5.8S rRNA (GO:0000460)2.98101287
73DNA replication-independent nucleosome organization (GO:0034724)2.97699197
74DNA replication-independent nucleosome assembly (GO:0006336)2.97699197
75negative regulation of telomerase activity (GO:0051974)2.97374435
76platelet dense granule organization (GO:0060155)2.95734835
77inner mitochondrial membrane organization (GO:0007007)2.94968852
78positive regulation of ligase activity (GO:0051351)2.94225492
79protein-cofactor linkage (GO:0018065)2.93677866
80signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92986150
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.92986150
82rRNA catabolic process (GO:0016075)2.92933807
83signal transduction involved in cell cycle checkpoint (GO:0072395)2.92850066
84ATP biosynthetic process (GO:0006754)2.92337847
85positive regulation of interleukin-8 secretion (GO:2000484)2.90917892
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90301685
87DNA replication-dependent nucleosome organization (GO:0034723)2.89159372
88DNA replication-dependent nucleosome assembly (GO:0006335)2.89159372
89negative regulation of chromosome segregation (GO:0051985)2.87741754
90protein complex biogenesis (GO:0070271)2.85760323
91mitochondrial respiratory chain complex assembly (GO:0033108)2.85096759
92regulation of ubiquitin-protein transferase activity (GO:0051438)2.84780868
93ncRNA catabolic process (GO:0034661)2.79682147
94mitotic spindle assembly checkpoint (GO:0007094)2.78904100
95negative regulation of lymphocyte apoptotic process (GO:0070229)2.78060316
96eosinophil migration (GO:0072677)2.76019921
97negative regulation of viral genome replication (GO:0045071)2.75067104
98mitotic spindle checkpoint (GO:0071174)2.74861963
99protein localization to mitochondrion (GO:0070585)2.74218256
100ncRNA 3-end processing (GO:0043628)2.73927742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.26757324
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.29774276
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.83228871
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.61653496
5CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.13250196
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00888161
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98130987
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85353068
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65643887
10ELK1_19687146_ChIP-ChIP_HELA_Human2.63119291
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60712868
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.59562725
13VDR_23849224_ChIP-Seq_CD4+_Human2.55495305
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.44642738
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.42572322
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28428019
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.18170715
18FOXP3_21729870_ChIP-Seq_TREG_Human2.12991452
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09436639
20VDR_22108803_ChIP-Seq_LS180_Human2.06576253
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93863288
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88437909
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81489986
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.81130380
25ZNF274_21170338_ChIP-Seq_K562_Hela1.78456130
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73385926
27EWS_26573619_Chip-Seq_HEK293_Human1.73238168
28E2F7_22180533_ChIP-Seq_HELA_Human1.72241354
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69088113
30MYC_18940864_ChIP-ChIP_HL60_Human1.68095568
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.66363435
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65084881
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.58375295
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55541162
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54080740
36IGF1R_20145208_ChIP-Seq_DFB_Human1.52650988
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50326982
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45244406
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44413367
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41664756
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41060518
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39491847
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39342185
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38614404
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36419727
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34765664
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.32290266
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30970419
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30818320
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.30632496
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28446775
52GABP_19822575_ChIP-Seq_HepG2_Human1.26054619
53P300_19829295_ChIP-Seq_ESCs_Human1.24716880
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20920785
55FUS_26573619_Chip-Seq_HEK293_Human1.20752842
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20617030
57HTT_18923047_ChIP-ChIP_STHdh_Human1.19921745
58CBP_20019798_ChIP-Seq_JUKART_Human1.19878166
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19878166
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18742034
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17955665
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.17877380
63DCP1A_22483619_ChIP-Seq_HELA_Human1.17753741
64SOX2_19829295_ChIP-Seq_ESCs_Human1.17162437
65NANOG_19829295_ChIP-Seq_ESCs_Human1.17162437
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16899182
67TTF2_22483619_ChIP-Seq_HELA_Human1.15880733
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15123364
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14253277
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.11951804
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11951804
72XRN2_22483619_ChIP-Seq_HELA_Human1.11271321
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10324530
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.09958697
75TP53_22573176_ChIP-Seq_HFKS_Human1.07308220
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06319946
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.03079816
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00763284
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00591970
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00075644
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00031910
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99771633
83POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99167149
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.97774751
85YY1_21170310_ChIP-Seq_MESCs_Mouse0.97201154
86AR_20517297_ChIP-Seq_VCAP_Human0.96536244
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96315424
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94009900
89RBPJ_21746931_ChIP-Seq_IB4_Human0.93826919
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92683343
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92600338
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92556036
93MYB_26560356_Chip-Seq_TH2_Human0.92460094
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91817795
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91697621
96TAF15_26573619_Chip-Seq_HEK293_Human0.91121356
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89838077
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.88939081
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85860833
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85783827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.55331603
2MP0003941_abnormal_skin_development4.33548139
3MP0005671_abnormal_response_to3.54439637
4MP0008877_abnormal_DNA_methylation3.00168755
5MP0006072_abnormal_retinal_apoptosis2.71169390
6MP0006292_abnormal_olfactory_placode2.62954283
7MP0005377_hearing/vestibular/ear_phenot2.52243968
8MP0003878_abnormal_ear_physiology2.52243968
9MP0003786_premature_aging2.45443867
10MP0001485_abnormal_pinna_reflex2.18351078
11MP0004957_abnormal_blastocyst_morpholog2.16363299
12MP0003646_muscle_fatigue2.16288560
13MP0002277_abnormal_respiratory_mucosa2.15344380
14MP0003693_abnormal_embryo_hatching2.12060857
15MP0002102_abnormal_ear_morphology2.00488974
16MP0003136_yellow_coat_color1.94074395
17MP0002736_abnormal_nociception_after1.90146600
18MP0008007_abnormal_cellular_replicative1.82696941
19MP0006035_abnormal_mitochondrial_morpho1.73115241
20MP0001873_stomach_inflammation1.72526351
21MP0003448_altered_tumor_morphology1.71862587
22MP0002933_joint_inflammation1.69339807
23MP0003567_abnormal_fetal_cardiomyocyte1.69313000
24MP0009785_altered_susceptibility_to1.64566733
25MP0003111_abnormal_nucleus_morphology1.60011678
26MP0004147_increased_porphyrin_level1.59550346
27MP0002837_dystrophic_cardiac_calcinosis1.53861875
28MP0008872_abnormal_physiological_respon1.53654134
29MP0010094_abnormal_chromosome_stability1.47969985
30MP0000579_abnormal_nail_morphology1.46500930
31MP0003137_abnormal_impulse_conducting1.44542702
32MP0006036_abnormal_mitochondrial_physio1.43886355
33MP0005084_abnormal_gallbladder_morpholo1.35798259
34MP0005253_abnormal_eye_physiology1.35654566
35MP0005083_abnormal_biliary_tract1.33888729
36MP0001661_extended_life_span1.32885728
37MP0008932_abnormal_embryonic_tissue1.32050205
38MP0003763_abnormal_thymus_physiology1.31977442
39MP0001968_abnormal_touch/_nociception1.28568334
40MP0009379_abnormal_foot_pigmentation1.28538900
41MP0004134_abnormal_chest_morphology1.27277675
42MP0003938_abnormal_ear_development1.25682778
43MP0003806_abnormal_nucleotide_metabolis1.25052543
44MP0009333_abnormal_splenocyte_physiolog1.21480039
45MP0003195_calcinosis1.20801571
46MP0008789_abnormal_olfactory_epithelium1.14201564
47MP0001984_abnormal_olfaction1.13288314
48MP0003718_maternal_effect1.10640746
49MP0005645_abnormal_hypothalamus_physiol1.09652891
50MP0001529_abnormal_vocalization1.06678646
51MP0000703_abnormal_thymus_morphology1.06157976
52MP0000647_abnormal_sebaceous_gland1.05194604
53MP0002138_abnormal_hepatobiliary_system1.01438598
54MP0001542_abnormal_bone_strength1.00770698
55MP0008995_early_reproductive_senescence1.00375615
56MP0000467_abnormal_esophagus_morphology1.00346837
57MP0003119_abnormal_digestive_system0.98868249
58MP0001293_anophthalmia0.97998832
59MP0000689_abnormal_spleen_morphology0.97917177
60MP0008058_abnormal_DNA_repair0.96644649
61MP0001919_abnormal_reproductive_system0.96602860
62MP0003787_abnormal_imprinting0.96506486
63MP0002420_abnormal_adaptive_immunity0.92739679
64MP0004885_abnormal_endolymph0.91034916
65MP0002722_abnormal_immune_system0.89550731
66MP0005389_reproductive_system_phenotype0.89075898
67MP0008875_abnormal_xenobiotic_pharmacok0.88649193
68MP0000049_abnormal_middle_ear0.87891070
69MP0001819_abnormal_immune_cell0.87081256
70MP0001800_abnormal_humoral_immune0.85021518
71MP0006082_CNS_inflammation0.84794545
72MP0003011_delayed_dark_adaptation0.84374136
73MP0004145_abnormal_muscle_electrophysio0.83218116
74MP0002006_tumorigenesis0.82931645
75MP0004215_abnormal_myocardial_fiber0.82546614
76MP0005551_abnormal_eye_electrophysiolog0.80523551
77MP0005000_abnormal_immune_tolerance0.80429167
78MP0001764_abnormal_homeostasis0.78677310
79MP0001119_abnormal_female_reproductive0.76777064
80MP0000716_abnormal_immune_system0.76220225
81MP0001835_abnormal_antigen_presentation0.75469272
82MP0004742_abnormal_vestibular_system0.75168997
83MP0003077_abnormal_cell_cycle0.74968459
84MP0009763_increased_sensitivity_to0.74677571
85MP0002398_abnormal_bone_marrow0.73685191
86MP0002723_abnormal_immune_serum0.73280062
87MP0009745_abnormal_behavioral_response0.72129621
88MP0003880_abnormal_central_pattern0.70381519
89MP0005410_abnormal_fertilization0.69897628
90MP0003866_abnormal_defecation0.69826001
91MP0001145_abnormal_male_reproductive0.67330633
92MP0002166_altered_tumor_susceptibility0.64869151
93MP0002751_abnormal_autonomic_nervous0.62988433
94MP0000653_abnormal_sex_gland0.62717842
95MP0002148_abnormal_hypersensitivity_rea0.62690247
96MP0002909_abnormal_adrenal_gland0.62409195
97MP0002429_abnormal_blood_cell0.60809166
98MP0002210_abnormal_sex_determination0.60415483
99MP0005025_abnormal_response_to0.59435679
100MP0005636_abnormal_mineral_homeostasis0.59431172

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.72087759
2Mitochondrial inheritance (HP:0001427)3.96811261
3Acute necrotizing encephalopathy (HP:0006965)3.93188737
4Acute encephalopathy (HP:0006846)3.81791829
5Hyperglycinemia (HP:0002154)3.64317044
6Increased hepatocellular lipid droplets (HP:0006565)3.59052634
7Abnormal mitochondria in muscle tissue (HP:0008316)3.54474318
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.50098753
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.50098753
103-Methylglutaconic aciduria (HP:0003535)3.30581133
11Increased CSF lactate (HP:0002490)3.22299281
12Progressive macrocephaly (HP:0004481)3.21498449
13Cerebral edema (HP:0002181)3.16922043
14Confusion (HP:0001289)3.04360407
15Rib fusion (HP:0000902)3.01245752
16Increased intramyocellular lipid droplets (HP:0012240)2.95502603
17Lipid accumulation in hepatocytes (HP:0006561)2.93409462
18Methylmalonic aciduria (HP:0012120)2.88771125
19Abnormal number of erythroid precursors (HP:0012131)2.86392322
20Hepatocellular necrosis (HP:0001404)2.81770735
21Abnormality of glycine metabolism (HP:0010895)2.78059556
22Abnormality of serine family amino acid metabolism (HP:0010894)2.78059556
23True hermaphroditism (HP:0010459)2.77563449
24Decreased central vision (HP:0007663)2.77480163
25Renal Fanconi syndrome (HP:0001994)2.76132312
26Septo-optic dysplasia (HP:0100842)2.74552085
27Hypoproteinemia (HP:0003075)2.73194151
28IgG deficiency (HP:0004315)2.72574629
29Abnormality of the labia minora (HP:0012880)2.68600007
30Abnormality of serum amino acid levels (HP:0003112)2.68248970
31Methylmalonic acidemia (HP:0002912)2.61412746
32Molar tooth sign on MRI (HP:0002419)2.61373106
33Abnormality of midbrain morphology (HP:0002418)2.61373106
34Pancytopenia (HP:0001876)2.60805034
35Lethargy (HP:0001254)2.59511244
36Severe combined immunodeficiency (HP:0004430)2.57920969
37Pendular nystagmus (HP:0012043)2.50127683
38Abolished electroretinogram (ERG) (HP:0000550)2.49681913
39Colon cancer (HP:0003003)2.49279973
40Pancreatic fibrosis (HP:0100732)2.45954480
41Lactic acidosis (HP:0003128)2.42230641
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38459101
43Increased serum lactate (HP:0002151)2.34585777
44Abnormality of cells of the erythroid lineage (HP:0012130)2.33495755
45IgM deficiency (HP:0002850)2.29844687
46Pancreatic cysts (HP:0001737)2.28128069
47Hyperglycinuria (HP:0003108)2.27704111
48Stenosis of the external auditory canal (HP:0000402)2.24751932
49Hepatic necrosis (HP:0002605)2.19409515
50Oral leukoplakia (HP:0002745)2.18450376
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17903757
52Combined immunodeficiency (HP:0005387)2.16098109
53Amniotic constriction ring (HP:0009775)2.14310446
54Abnormality of placental membranes (HP:0011409)2.14310446
55Lymphopenia (HP:0001888)2.13837872
56Bile duct proliferation (HP:0001408)2.12723740
57Abnormal biliary tract physiology (HP:0012439)2.12723740
58Increased muscle lipid content (HP:0009058)2.12499546
59Exertional dyspnea (HP:0002875)2.10338475
60Exercise intolerance (HP:0003546)2.09651963
61Hypoplasia of the thymus (HP:0000778)2.09572130
62Anomalous pulmonary venous return (HP:0010772)2.09057019
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07487638
64Respiratory failure (HP:0002878)2.03516388
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03430417
66Thyroiditis (HP:0100646)2.03422667
67Anencephaly (HP:0002323)2.02186265
68Panhypogammaglobulinemia (HP:0003139)2.01992093
69Optic disc pallor (HP:0000543)2.01622489
70Pancreatic islet-cell hyperplasia (HP:0004510)1.99535610
71Respiratory difficulties (HP:0002880)1.93126880
72Hyperinsulinemic hypoglycemia (HP:0000825)1.91289643
73Esophageal atresia (HP:0002032)1.88436141
74Congenital stationary night blindness (HP:0007642)1.88126498
75Limb hypertonia (HP:0002509)1.87868895
76Absent septum pellucidum (HP:0001331)1.86249315
77Abnormal lung lobation (HP:0002101)1.86183308
78Hypoplasia of the pons (HP:0012110)1.85626452
79Abnormality of cells of the lymphoid lineage (HP:0012140)1.83665180
80Abnormal number of incisors (HP:0011064)1.83443029
81Congenital, generalized hypertrichosis (HP:0004540)1.82918579
82Abnormality of the pulmonary veins (HP:0011718)1.81042647
83Leukodystrophy (HP:0002415)1.80003804
84Patellar aplasia (HP:0006443)1.79678364
85Bifid tongue (HP:0010297)1.79312518
86Meckel diverticulum (HP:0002245)1.78725588
87Fused cervical vertebrae (HP:0002949)1.78469451
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77278746
89Abnormality of alanine metabolism (HP:0010916)1.77278746
90Hyperalaninemia (HP:0003348)1.77278746
91Encephalitis (HP:0002383)1.75967205
92Erythroderma (HP:0001019)1.75615222
93Autoimmune hemolytic anemia (HP:0001890)1.75371863
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72145003
95Cellular immunodeficiency (HP:0005374)1.70988861
96Abnormality of eosinophils (HP:0001879)1.70393318
97Absent radius (HP:0003974)1.69663483
98Attenuation of retinal blood vessels (HP:0007843)1.69406061
99Abnormality of renal resorption (HP:0011038)1.69403280
100Absent thumb (HP:0009777)1.69178019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.41649049
2TRIM283.91565731
3BUB13.73162430
4KDR3.42375334
5TXK3.26436715
6ZAK3.16158077
7VRK22.77668647
8EIF2AK32.70489180
9MAP4K22.53599184
10MKNK22.26619937
11NUAK12.18037285
12ACVR1B2.10643486
13ADRBK22.08393612
14STK161.99360516
15SRPK11.89265214
16PLK41.86096948
17CDC71.84336824
18WNK31.83232276
19OXSR11.77267852
20BMPR1B1.68110087
21BCKDK1.66665596
22MKNK11.49711976
23PLK31.40832752
24EIF2AK11.33078785
25VRK11.31012729
26TTK1.29444042
27STK38L1.29428485
28FRK1.26488379
29GRK11.26199463
30CDK191.23847047
31STK391.21856669
32PLK21.20608077
33TESK21.12633936
34PIK3CA1.10159771
35TNIK1.09981328
36TIE11.09886668
37MAP4K11.03955315
38PLK11.02876710
39DYRK21.01968545
40EPHA41.00520568
41MAP3K121.00113927
42PBK0.88765106
43ITK0.87510546
44NME10.83806763
45GRK70.81799664
46ATR0.77227040
47EIF2AK20.73407684
48NEK10.72528430
49TAF10.71168662
50ZAP700.70924527
51INSRR0.68633163
52CSNK1G10.68611372
53BCR0.62976943
54TSSK60.62019535
55CSNK2A10.55875245
56TEC0.55775453
57AURKB0.53198439
58NLK0.52698427
59SYK0.52689791
60FES0.52250298
61FGFR20.51207680
62MAP3K110.50609564
63OBSCN0.50141135
64CSNK1G30.48143745
65CSNK2A20.48106643
66CSF1R0.47727105
67WNK40.46377228
68LCK0.45330383
69BTK0.44376064
70RPS6KA50.44186868
71PRKCQ0.42996136
72MELK0.42602581
73CSNK1G20.42438207
74CSK0.41340032
75IKBKB0.40783592
76LYN0.40753304
77TAOK30.40644748
78MAP3K50.40591360
79PRKCE0.39436503
80CSNK1A10.39388745
81ERBB30.38862950
82MYLK0.37738199
83ATM0.37158794
84PIM10.35951539
85ADRBK10.35712931
86INSR0.34002959
87DYRK30.32713403
88AURKA0.32542081
89NME20.31146723
90PRKCG0.30934671
91LIMK10.30795827
92ROCK10.30778536
93TYRO30.30503847
94PRKCA0.30347639
95IGF1R0.29351222
96PAK40.29071908
97BRD40.28330897
98CSNK1A1L0.28319622
99TGFBR10.28035851
100RPS6KA40.27925624

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.83761255
2Oxidative phosphorylation_Homo sapiens_hsa001903.75652553
3RNA polymerase_Homo sapiens_hsa030203.48023369
4Parkinsons disease_Homo sapiens_hsa050123.33234348
5Primary immunodeficiency_Homo sapiens_hsa053402.68017440
6Protein export_Homo sapiens_hsa030602.63663591
7Ribosome_Homo sapiens_hsa030102.60197936
8Propanoate metabolism_Homo sapiens_hsa006402.33514829
9Huntingtons disease_Homo sapiens_hsa050162.22076512
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15014987
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.12515697
12Homologous recombination_Homo sapiens_hsa034402.12044437
13Alzheimers disease_Homo sapiens_hsa050102.11188311
14Spliceosome_Homo sapiens_hsa030401.99873821
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87304457
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81084095
17DNA replication_Homo sapiens_hsa030301.74911593
18RNA degradation_Homo sapiens_hsa030181.73536088
19Mismatch repair_Homo sapiens_hsa034301.71541538
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62996032
21RNA transport_Homo sapiens_hsa030131.62209465
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61896768
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61128791
24Cardiac muscle contraction_Homo sapiens_hsa042601.54426783
25Pyrimidine metabolism_Homo sapiens_hsa002401.50455126
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47535893
27One carbon pool by folate_Homo sapiens_hsa006701.43360666
28Caffeine metabolism_Homo sapiens_hsa002321.36893724
29Fanconi anemia pathway_Homo sapiens_hsa034601.32367348
30Basal transcription factors_Homo sapiens_hsa030221.30653291
31Hematopoietic cell lineage_Homo sapiens_hsa046401.25800511
32Autoimmune thyroid disease_Homo sapiens_hsa053201.21683273
33Graft-versus-host disease_Homo sapiens_hsa053321.21654348
34Purine metabolism_Homo sapiens_hsa002301.15413939
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14388416
36Nucleotide excision repair_Homo sapiens_hsa034201.11455773
37Allograft rejection_Homo sapiens_hsa053301.10221308
38Selenocompound metabolism_Homo sapiens_hsa004501.05687016
39Non-homologous end-joining_Homo sapiens_hsa034501.05201120
40Butanoate metabolism_Homo sapiens_hsa006501.04922340
41Phototransduction_Homo sapiens_hsa047441.03798783
42Rheumatoid arthritis_Homo sapiens_hsa053231.02304149
43Type I diabetes mellitus_Homo sapiens_hsa049401.00598980
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00051578
45Pyruvate metabolism_Homo sapiens_hsa006200.95598450
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90476896
47Fatty acid elongation_Homo sapiens_hsa000620.89397714
48Linoleic acid metabolism_Homo sapiens_hsa005910.84488101
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.81711731
50Cell cycle_Homo sapiens_hsa041100.79172570
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78857391
52Antigen processing and presentation_Homo sapiens_hsa046120.78210243
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74867743
54Retinol metabolism_Homo sapiens_hsa008300.72336553
55Nitrogen metabolism_Homo sapiens_hsa009100.72152052
56Tryptophan metabolism_Homo sapiens_hsa003800.70839660
57Metabolic pathways_Homo sapiens_hsa011000.68808008
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67609029
59Peroxisome_Homo sapiens_hsa041460.66697519
60Salmonella infection_Homo sapiens_hsa051320.63972886
61Vitamin digestion and absorption_Homo sapiens_hsa049770.63099522
62Olfactory transduction_Homo sapiens_hsa047400.62074817
63Arginine biosynthesis_Homo sapiens_hsa002200.62021135
64beta-Alanine metabolism_Homo sapiens_hsa004100.59173260
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57293989
66Biosynthesis of amino acids_Homo sapiens_hsa012300.56821395
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52700320
68Fatty acid metabolism_Homo sapiens_hsa012120.51597784
69Fatty acid degradation_Homo sapiens_hsa000710.51438151
70Systemic lupus erythematosus_Homo sapiens_hsa053220.51309703
71mRNA surveillance pathway_Homo sapiens_hsa030150.50619111
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47635154
73Steroid biosynthesis_Homo sapiens_hsa001000.46081142
74Chemical carcinogenesis_Homo sapiens_hsa052040.45759936
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45223374
76Epstein-Barr virus infection_Homo sapiens_hsa051690.45013583
77Base excision repair_Homo sapiens_hsa034100.44656120
78T cell receptor signaling pathway_Homo sapiens_hsa046600.44452853
79p53 signaling pathway_Homo sapiens_hsa041150.43840003
80Carbon metabolism_Homo sapiens_hsa012000.43769066
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43201863
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42538325
83Vitamin B6 metabolism_Homo sapiens_hsa007500.42177401
84Nicotine addiction_Homo sapiens_hsa050330.41833265
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40811558
86Asthma_Homo sapiens_hsa053100.40226704
87Oocyte meiosis_Homo sapiens_hsa041140.37969519
88Fat digestion and absorption_Homo sapiens_hsa049750.35793227
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34788449
90Folate biosynthesis_Homo sapiens_hsa007900.34195450
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32996727
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32082250
93Sulfur relay system_Homo sapiens_hsa041220.32039091
94Glutathione metabolism_Homo sapiens_hsa004800.30826084
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.30526617
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28976899
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27970998
98Measles_Homo sapiens_hsa051620.27048934
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26979211
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26513910

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