TERF1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.02520489
2chromatin remodeling at centromere (GO:0031055)4.89882847
3CENP-A containing nucleosome assembly (GO:0034080)4.81645998
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62344210
5protein-cofactor linkage (GO:0018065)4.44981346
6protein neddylation (GO:0045116)4.36002883
7histone exchange (GO:0043486)4.25290353
8pseudouridine synthesis (GO:0001522)4.12888026
9regulation of nuclear cell cycle DNA replication (GO:0033262)4.09922863
10regulation of mitotic spindle checkpoint (GO:1903504)4.08472374
11regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.08472374
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06890074
13ATP synthesis coupled proton transport (GO:0015986)4.06890074
14cullin deneddylation (GO:0010388)4.03176088
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02733194
16termination of RNA polymerase III transcription (GO:0006386)3.92672999
17transcription elongation from RNA polymerase III promoter (GO:0006385)3.92672999
18chaperone-mediated protein transport (GO:0072321)3.92534778
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.88283282
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.87959137
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.84396051
22protein deneddylation (GO:0000338)3.75407628
23respiratory chain complex IV assembly (GO:0008535)3.74744896
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.74359588
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.74359588
26DNA deamination (GO:0045006)3.70067451
27DNA double-strand break processing (GO:0000729)3.67998234
28negative regulation of telomere maintenance (GO:0032205)3.66784660
29respiratory electron transport chain (GO:0022904)3.58785622
30electron transport chain (GO:0022900)3.54036721
31DNA replication-independent nucleosome assembly (GO:0006336)3.45596951
32DNA replication-independent nucleosome organization (GO:0034724)3.45596951
33water-soluble vitamin biosynthetic process (GO:0042364)3.41220770
34fucose catabolic process (GO:0019317)3.40973068
35L-fucose metabolic process (GO:0042354)3.40973068
36L-fucose catabolic process (GO:0042355)3.40973068
37negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.35115803
38somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.30030737
39somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.30030737
40isotype switching (GO:0045190)3.30030737
41proteasome assembly (GO:0043248)3.24597490
42branched-chain amino acid catabolic process (GO:0009083)3.23157184
43regulation of telomere maintenance via telomerase (GO:0032210)3.22171582
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18829990
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.16524348
46NADH dehydrogenase complex assembly (GO:0010257)3.16524348
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16524348
48protein complex biogenesis (GO:0070271)3.15946976
49histone mRNA metabolic process (GO:0008334)3.13212883
50cytochrome complex assembly (GO:0017004)3.11291666
51behavioral response to nicotine (GO:0035095)3.07578986
52mitochondrial respiratory chain complex assembly (GO:0033108)3.07269507
53mitotic metaphase plate congression (GO:0007080)2.99534869
54maturation of 5.8S rRNA (GO:0000460)2.98328741
55rRNA modification (GO:0000154)2.93981681
56metallo-sulfur cluster assembly (GO:0031163)2.87420245
57iron-sulfur cluster assembly (GO:0016226)2.87420245
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86817777
59DNA damage response, detection of DNA damage (GO:0042769)2.86598294
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85858587
61kinetochore assembly (GO:0051382)2.83075119
62recombinational repair (GO:0000725)2.81071119
63telomere maintenance via telomerase (GO:0007004)2.79878703
64tRNA processing (GO:0008033)2.78993069
65double-strand break repair via homologous recombination (GO:0000724)2.78503091
66centriole replication (GO:0007099)2.78010743
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77432897
68negative regulation of ligase activity (GO:0051352)2.77432897
69maturation of SSU-rRNA (GO:0030490)2.77097146
70DNA catabolic process, exonucleolytic (GO:0000738)2.75417922
71platelet dense granule organization (GO:0060155)2.75026009
72male meiosis I (GO:0007141)2.74899854
73DNA replication checkpoint (GO:0000076)2.72035257
74cytidine deamination (GO:0009972)2.70703173
75cytidine metabolic process (GO:0046087)2.70703173
76cytidine catabolic process (GO:0006216)2.70703173
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67490033
78regulation of cellular amino acid metabolic process (GO:0006521)2.67457188
79protein targeting to mitochondrion (GO:0006626)2.66058988
80inner mitochondrial membrane organization (GO:0007007)2.64933345
81organelle disassembly (GO:1903008)2.63521439
82regulation of helicase activity (GO:0051095)2.63352770
83regulation of meiosis I (GO:0060631)2.62191652
84ncRNA catabolic process (GO:0034661)2.61232167
85replication fork processing (GO:0031297)2.56921366
86establishment of protein localization to mitochondrion (GO:0072655)2.56174440
87rRNA catabolic process (GO:0016075)2.55907000
88RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55187484
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54996057
90regulation of DNA endoreduplication (GO:0032875)2.54946764
91mismatch repair (GO:0006298)2.54787204
92rRNA metabolic process (GO:0016072)2.54618923
93kinetochore organization (GO:0051383)2.54473909
94protein localization to mitochondrion (GO:0070585)2.54399147
95rRNA processing (GO:0006364)2.53888715
96regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.53241578
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53196109
98galactose catabolic process (GO:0019388)2.52280347
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.52279754
100regulation of translation, ncRNA-mediated (GO:0045974)2.52279754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.32729140
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.10603222
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.59979652
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59692870
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15803832
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.05039135
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86072660
8ZNF274_21170338_ChIP-Seq_K562_Hela2.68801494
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66847304
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60393987
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48691802
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.43214049
13ELK1_19687146_ChIP-ChIP_HELA_Human2.41844474
14E2F7_22180533_ChIP-Seq_HELA_Human2.40636074
15VDR_22108803_ChIP-Seq_LS180_Human2.27252013
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25294844
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.24745434
18VDR_23849224_ChIP-Seq_CD4+_Human2.22636838
19EWS_26573619_Chip-Seq_HEK293_Human2.17416922
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.15816727
21MYC_18940864_ChIP-ChIP_HL60_Human2.13615319
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12490818
23FOXP3_21729870_ChIP-Seq_TREG_Human2.04142015
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.01786541
25IGF1R_20145208_ChIP-Seq_DFB_Human1.94728156
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86245897
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.85876516
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81876884
29FUS_26573619_Chip-Seq_HEK293_Human1.79657309
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77637488
31TAF15_26573619_Chip-Seq_HEK293_Human1.72110368
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71809604
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70616133
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.67154669
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.64134922
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63040355
37P300_19829295_ChIP-Seq_ESCs_Human1.51834282
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51325194
39NANOG_16153702_ChIP-ChIP_HESCs_Human1.51290472
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51141405
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50652976
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47264059
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45898407
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40430367
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38417192
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30425088
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30377171
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29811627
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29056772
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28824852
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.27320580
52GABP_19822575_ChIP-Seq_HepG2_Human1.26836142
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.26834446
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26405426
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24877164
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23755712
57TTF2_22483619_ChIP-Seq_HELA_Human1.22704343
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22000333
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.21330250
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20202967
61TP53_22573176_ChIP-Seq_HFKS_Human1.14997028
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14021185
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12081355
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11225880
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09427705
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07889717
67SOX2_19829295_ChIP-Seq_ESCs_Human1.07870891
68NANOG_19829295_ChIP-Seq_ESCs_Human1.07870891
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06279293
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.06244767
71GBX2_23144817_ChIP-Seq_PC3_Human1.06162400
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04941489
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04774268
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03473132
75DCP1A_22483619_ChIP-Seq_HELA_Human1.03300129
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02894716
77FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99653411
78FOXA1_25329375_ChIP-Seq_VCAP_Human0.99653411
79NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97636813
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96780603
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96643296
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96643296
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96643296
84AR_20517297_ChIP-Seq_VCAP_Human0.95195998
85SALL1_21062744_ChIP-ChIP_HESCs_Human0.94795220
86ER_23166858_ChIP-Seq_MCF-7_Human0.94503613
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94104675
88CBP_20019798_ChIP-Seq_JUKART_Human0.94104675
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92206364
90E2F1_21310950_ChIP-Seq_MCF-7_Human0.92021285
91NANOG_20526341_ChIP-Seq_ESCs_Human0.91739764
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.89877184
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89715052
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89100172
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89035061
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87976691
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87286690
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87286690
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86071959
100ETV1_20927104_ChIP-Seq_GIST48_Human0.85297285

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.70838551
2MP0006292_abnormal_olfactory_placode3.66317319
3MP0008877_abnormal_DNA_methylation3.28567666
4MP0002736_abnormal_nociception_after2.83447751
5MP0008058_abnormal_DNA_repair2.82428727
6MP0003136_yellow_coat_color2.74372413
7MP0003195_calcinosis2.34305051
8MP0002102_abnormal_ear_morphology2.29723119
9MP0002938_white_spotting2.26578798
10MP0005377_hearing/vestibular/ear_phenot2.24245805
11MP0003878_abnormal_ear_physiology2.24245805
12MP0003693_abnormal_embryo_hatching2.22908193
13MP0003941_abnormal_skin_development2.13273387
14MP0006072_abnormal_retinal_apoptosis2.11943757
15MP0004885_abnormal_endolymph2.10854608
16MP0003122_maternal_imprinting2.04535035
17MP0005646_abnormal_pituitary_gland1.95498274
18MP0002234_abnormal_pharynx_morphology1.94017846
19MP0001485_abnormal_pinna_reflex1.93407632
20MP0001968_abnormal_touch/_nociception1.85404873
21MP0004957_abnormal_blastocyst_morpholog1.82521469
22MP0001764_abnormal_homeostasis1.82501211
23MP0001984_abnormal_olfaction1.78433277
24MP0001529_abnormal_vocalization1.78024391
25MP0010094_abnormal_chromosome_stability1.72448083
26MP0008932_abnormal_embryonic_tissue1.65599491
27MP0008789_abnormal_olfactory_epithelium1.65454498
28MP0003787_abnormal_imprinting1.65178677
29MP0005075_abnormal_melanosome_morpholog1.61638338
30MP0000049_abnormal_middle_ear1.60853833
31MP0002837_dystrophic_cardiac_calcinosis1.59013854
32MP0001293_anophthalmia1.57560889
33MP0001986_abnormal_taste_sensitivity1.53945424
34MP0005645_abnormal_hypothalamus_physiol1.53547979
35MP0003938_abnormal_ear_development1.52308095
36MP0000372_irregular_coat_pigmentation1.51120711
37MP0003121_genomic_imprinting1.50584120
38MP0008007_abnormal_cellular_replicative1.49585029
39MP0004133_heterotaxia1.49395826
40MP0002277_abnormal_respiratory_mucosa1.48237556
41MP0003567_abnormal_fetal_cardiomyocyte1.43442345
42MP0000631_abnormal_neuroendocrine_gland1.42110615
43MP0002160_abnormal_reproductive_system1.41438297
44MP0003011_delayed_dark_adaptation1.40541674
45MP0003111_abnormal_nucleus_morphology1.39884183
46MP0008872_abnormal_physiological_respon1.34822273
47MP0006036_abnormal_mitochondrial_physio1.33640723
48MP0004147_increased_porphyrin_level1.33568441
49MP0005551_abnormal_eye_electrophysiolog1.31206457
50MP0003937_abnormal_limbs/digits/tail_de1.28718471
51MP0002095_abnormal_skin_pigmentation1.27520751
52MP0003786_premature_aging1.25269562
53MP0003718_maternal_effect1.24786052
54MP0003646_muscle_fatigue1.22845862
55MP0002822_catalepsy1.22155132
56MP0004043_abnormal_pH_regulation1.21257977
57MP0006276_abnormal_autonomic_nervous1.20339659
58MP0005389_reproductive_system_phenotype1.19671123
59MP0005671_abnormal_response_to1.19173862
60MP0003119_abnormal_digestive_system1.18700361
61MP0005253_abnormal_eye_physiology1.13400016
62MP0008995_early_reproductive_senescence1.10889702
63MP0003890_abnormal_embryonic-extraembry1.07246240
64MP0008875_abnormal_xenobiotic_pharmacok1.00353461
65MP0005394_taste/olfaction_phenotype1.00267927
66MP0005499_abnormal_olfactory_system1.00267927
67MP0009745_abnormal_behavioral_response0.99113489
68MP0001286_abnormal_eye_development0.98951316
69MP0010386_abnormal_urinary_bladder0.98327726
70MP0001486_abnormal_startle_reflex0.95463217
71MP0005084_abnormal_gallbladder_morpholo0.93042074
72MP0002751_abnormal_autonomic_nervous0.92527697
73MP0005423_abnormal_somatic_nervous0.91728372
74MP0001542_abnormal_bone_strength0.90053718
75MP0002272_abnormal_nervous_system0.87478424
76MP0003077_abnormal_cell_cycle0.86407428
77MP0004145_abnormal_muscle_electrophysio0.85206578
78MP0005174_abnormal_tail_pigmentation0.84760354
79MP0009046_muscle_twitch0.83797469
80MP0006035_abnormal_mitochondrial_morpho0.81819281
81MP0004019_abnormal_vitamin_homeostasis0.81787327
82MP0001963_abnormal_hearing_physiology0.80191570
83MP0000026_abnormal_inner_ear0.79899445
84MP0004215_abnormal_myocardial_fiber0.74102231
85MP0003137_abnormal_impulse_conducting0.73674686
86MP0000579_abnormal_nail_morphology0.73366142
87MP0001145_abnormal_male_reproductive0.73239965
88MP0002210_abnormal_sex_determination0.73167080
89MP0005636_abnormal_mineral_homeostasis0.72833970
90MP0000653_abnormal_sex_gland0.72490799
91MP0004742_abnormal_vestibular_system0.72397767
92MP0002233_abnormal_nose_morphology0.71323727
93MP0001177_atelectasis0.70734948
94MP0001919_abnormal_reproductive_system0.68546722
95MP0001929_abnormal_gametogenesis0.68272571
96MP0001666_abnormal_nutrient_absorption0.65709856
97MP0002254_reproductive_system_inflammat0.65250439
98MP0002638_abnormal_pupillary_reflex0.64942552
99MP0002752_abnormal_somatic_nervous0.64853470
100MP0005391_vision/eye_phenotype0.64616831

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.45258847
2Increased hepatocellular lipid droplets (HP:0006565)4.14072017
3Acute encephalopathy (HP:0006846)4.09865187
4Chronic hepatic failure (HP:0100626)4.08390283
5Mitochondrial inheritance (HP:0001427)4.03506601
6Abnormal mitochondria in muscle tissue (HP:0008316)3.83028214
7Progressive macrocephaly (HP:0004481)3.68476403
8Lipid accumulation in hepatocytes (HP:0006561)3.66958873
9Increased CSF lactate (HP:0002490)3.58400295
10Abnormality of the labia minora (HP:0012880)3.51323026
11Colon cancer (HP:0003003)3.41910591
12Hyperglycinemia (HP:0002154)3.26827944
13Renal Fanconi syndrome (HP:0001994)3.19517316
14Hepatocellular necrosis (HP:0001404)3.11621279
153-Methylglutaconic aciduria (HP:0003535)3.07174174
16Abnormal number of erythroid precursors (HP:0012131)3.04869230
17Cerebral edema (HP:0002181)3.03792714
18Exertional dyspnea (HP:0002875)2.84009454
19Pancreatic cysts (HP:0001737)2.81606250
20Volvulus (HP:0002580)2.79535119
21Abnormality of renal resorption (HP:0011038)2.77824294
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62143089
23True hermaphroditism (HP:0010459)2.61563116
24Hepatic necrosis (HP:0002605)2.59470491
25Pancreatic fibrosis (HP:0100732)2.59141240
26Aplastic anemia (HP:0001915)2.56118370
27Increased intramyocellular lipid droplets (HP:0012240)2.54413405
28Septo-optic dysplasia (HP:0100842)2.49168711
29Abnormality of cells of the erythroid lineage (HP:0012130)2.48993472
30Abolished electroretinogram (ERG) (HP:0000550)2.46185034
31Abnormality of serine family amino acid metabolism (HP:0010894)2.41234342
32Abnormality of glycine metabolism (HP:0010895)2.41234342
33Optic disc pallor (HP:0000543)2.37366665
34Increased serum lactate (HP:0002151)2.35677085
35Hyperglycinuria (HP:0003108)2.33321915
36Abnormality of midbrain morphology (HP:0002418)2.33118711
37Molar tooth sign on MRI (HP:0002419)2.33118711
38Lactic acidosis (HP:0003128)2.30562674
39Pendular nystagmus (HP:0012043)2.28613245
40Abnormal biliary tract physiology (HP:0012439)2.28239946
41Bile duct proliferation (HP:0001408)2.28239946
42IgG deficiency (HP:0004315)2.27770519
43Abnormality of serum amino acid levels (HP:0003112)2.25580142
44Severe combined immunodeficiency (HP:0004430)2.24625245
45Respiratory failure (HP:0002878)2.23108275
46Methylmalonic acidemia (HP:0002912)2.22387754
47Lethargy (HP:0001254)2.21096533
48Premature ovarian failure (HP:0008209)2.20667336
49Respiratory difficulties (HP:0002880)2.18988772
50Type I transferrin isoform profile (HP:0003642)2.18534678
51Decreased central vision (HP:0007663)2.13239791
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09786850
53Nephronophthisis (HP:0000090)2.08840191
54Stenosis of the external auditory canal (HP:0000402)2.08127905
55Leukodystrophy (HP:0002415)2.08078061
56Congenital stationary night blindness (HP:0007642)2.07539610
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05801084
58Supernumerary spleens (HP:0009799)2.03875464
59Abnormality of chromosome stability (HP:0003220)2.00940008
60Methylmalonic aciduria (HP:0012120)1.99792837
61Congenital, generalized hypertrichosis (HP:0004540)1.97750947
62Exercise intolerance (HP:0003546)1.95946646
63Thyroiditis (HP:0100646)1.95642823
64Increased muscle lipid content (HP:0009058)1.93178023
65Optic nerve hypoplasia (HP:0000609)1.92394417
66Combined immunodeficiency (HP:0005387)1.90868876
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90706925
68Hyperinsulinemic hypoglycemia (HP:0000825)1.90383529
69Birth length less than 3rd percentile (HP:0003561)1.88015914
70Chronic bronchitis (HP:0004469)1.86709111
71Meckel diverticulum (HP:0002245)1.85676464
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85291500
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83979287
74Abnormal protein N-linked glycosylation (HP:0012347)1.83979287
75Abnormal protein glycosylation (HP:0012346)1.83979287
76Abnormal glycosylation (HP:0012345)1.83979287
77Abnormality of the ileum (HP:0001549)1.83271479
78Abnormality of the renal medulla (HP:0100957)1.83029183
79Absent septum pellucidum (HP:0001331)1.82720140
80Hypoplasia of the pons (HP:0012110)1.82582316
81Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80680185
82Abnormal lung lobation (HP:0002101)1.79896754
83Aplasia/hypoplasia of the uterus (HP:0008684)1.79457231
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78117466
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78117466
86Macrocytic anemia (HP:0001972)1.76165658
87Glycosuria (HP:0003076)1.74694891
88Abnormality of urine glucose concentration (HP:0011016)1.74694891
89Type II lissencephaly (HP:0007260)1.74282897
90Attenuation of retinal blood vessels (HP:0007843)1.72641977
91Intestinal atresia (HP:0011100)1.72143503
92CNS demyelination (HP:0007305)1.71997065
93Oligodactyly (hands) (HP:0001180)1.68599041
94Abnormality of the renal cortex (HP:0011035)1.68471596
95Abnormality of the preputium (HP:0100587)1.68006222
96Anencephaly (HP:0002323)1.67569245
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.67126872
98Hypoplastic pelvis (HP:0008839)1.66821881
99Chromsome breakage (HP:0040012)1.66757685
100Genital tract atresia (HP:0001827)1.65900592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.19415945
2MAP4K23.41675858
3TRIM283.36601211
4ZAK3.27734483
5BUB12.76284969
6VRK22.71660044
7NUAK12.62267500
8WNK32.47045098
9CDC72.39456011
10EIF2AK32.38449723
11BCKDK2.37927129
12SRPK12.28723479
13TXK2.28442892
14MST42.25409796
15MKNK21.94524629
16VRK11.81122354
17TAF11.79030580
18TNIK1.73192185
19GRK11.67586204
20EIF2AK11.67012978
21ADRBK21.64943634
22PASK1.64362362
23TTK1.61205291
24PLK31.59187967
25PLK41.53262148
26FRK1.51986822
27TLK11.51529259
28KDR1.49712398
29NME11.48937747
30OXSR11.45749978
31STK161.45417992
32BMPR1B1.44957307
33TSSK61.44206639
34DYRK21.40978241
35MKNK11.30413158
36CSNK1G11.27652824
37CSNK1G31.20763295
38PDK21.19426208
39CSNK1G21.07939755
40EIF2AK21.07465656
41CDK191.06164524
42PLK11.04247144
43ACVR1B1.03488836
44BCR0.98083067
45NEK10.97448623
46CSNK1A1L0.89412008
47STK390.87901714
48TIE10.81053493
49AURKB0.80984338
50CASK0.76806330
51MAPK130.76607602
52NLK0.76429699
53CHEK20.72444486
54STK38L0.72009206
55PINK10.71495456
56ERBB30.69016899
57INSRR0.68543021
58PLK20.66110438
59CSNK2A10.62579142
60ALK0.61837084
61CDK30.60916841
62PHKG10.58344514
63PHKG20.58344514
64FGFR20.56975745
65ATR0.56271847
66PRKCG0.55786825
67CSNK2A20.52611269
68FGFR10.50838276
69ATM0.49078232
70WNK40.47137693
71DYRK30.46799339
72TAOK10.45825794
73PIK3CA0.45779579
74WEE10.44093041
75PRKCQ0.43830247
76PRKCE0.43682513
77PBK0.41932718
78TESK20.39894707
79CSNK1A10.39857015
80PNCK0.39137657
81MAP3K40.38471335
82BRSK20.37065402
83MAP3K120.36257659
84CSNK1E0.35948536
85OBSCN0.34568061
86CHEK10.34285723
87RPS6KA50.32177410
88PRKACA0.30229672
89IKBKB0.29909319
90TGFBR10.29449703
91PRKCI0.29016741
92PRKDC0.28601886
93CSNK1D0.28129207
94MAP2K70.27874297
95CDK80.26033023
96TEC0.25681563
97PRKCA0.23984116
98IRAK40.23601113
99AURKA0.23056032
100DYRK1A0.22986659

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.71099901
2Protein export_Homo sapiens_hsa030603.37223392
3Oxidative phosphorylation_Homo sapiens_hsa001903.24736017
4Homologous recombination_Homo sapiens_hsa034402.88008224
5RNA polymerase_Homo sapiens_hsa030202.86848650
6Parkinsons disease_Homo sapiens_hsa050122.73432995
7Mismatch repair_Homo sapiens_hsa034302.63390786
8Ribosome_Homo sapiens_hsa030102.48248909
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31176963
10Basal transcription factors_Homo sapiens_hsa030222.24920715
11Sulfur relay system_Homo sapiens_hsa041222.21058423
12DNA replication_Homo sapiens_hsa030302.18405502
13Spliceosome_Homo sapiens_hsa030402.07367083
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02669637
15RNA degradation_Homo sapiens_hsa030181.99017019
16Huntingtons disease_Homo sapiens_hsa050161.98146691
17Propanoate metabolism_Homo sapiens_hsa006401.85979468
18One carbon pool by folate_Homo sapiens_hsa006701.74709436
19Phototransduction_Homo sapiens_hsa047441.72399752
20Alzheimers disease_Homo sapiens_hsa050101.70271204
21Nucleotide excision repair_Homo sapiens_hsa034201.67787822
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61983168
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61089227
24Fanconi anemia pathway_Homo sapiens_hsa034601.59921442
25Non-homologous end-joining_Homo sapiens_hsa034501.47746868
26RNA transport_Homo sapiens_hsa030131.46202055
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39848829
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.39504026
29Primary immunodeficiency_Homo sapiens_hsa053401.38528706
30Caffeine metabolism_Homo sapiens_hsa002321.33638848
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32950025
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30927890
33Pyrimidine metabolism_Homo sapiens_hsa002401.25639037
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25214023
35Selenocompound metabolism_Homo sapiens_hsa004501.24380339
36Cardiac muscle contraction_Homo sapiens_hsa042601.24364663
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22718452
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16138550
39Base excision repair_Homo sapiens_hsa034101.15847861
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12933314
41Purine metabolism_Homo sapiens_hsa002301.12443301
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08002801
43Nicotine addiction_Homo sapiens_hsa050331.01571307
44Vitamin B6 metabolism_Homo sapiens_hsa007501.01541619
45Nitrogen metabolism_Homo sapiens_hsa009100.96757855
46Sulfur metabolism_Homo sapiens_hsa009200.94397874
47Pyruvate metabolism_Homo sapiens_hsa006200.94111077
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93589085
49Vitamin digestion and absorption_Homo sapiens_hsa049770.86875307
50Steroid biosynthesis_Homo sapiens_hsa001000.85832102
51Butanoate metabolism_Homo sapiens_hsa006500.84766367
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83389650
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.81124891
54Peroxisome_Homo sapiens_hsa041460.77881604
55Tryptophan metabolism_Homo sapiens_hsa003800.77456929
56Linoleic acid metabolism_Homo sapiens_hsa005910.75482442
57Retinol metabolism_Homo sapiens_hsa008300.74780308
58Taste transduction_Homo sapiens_hsa047420.74388110
59Folate biosynthesis_Homo sapiens_hsa007900.73358500
60Metabolic pathways_Homo sapiens_hsa011000.72117781
61Fatty acid elongation_Homo sapiens_hsa000620.70310574
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69973233
63Cell cycle_Homo sapiens_hsa041100.68088114
64Fatty acid degradation_Homo sapiens_hsa000710.64096702
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.63505577
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63502918
67beta-Alanine metabolism_Homo sapiens_hsa004100.63276271
68Chemical carcinogenesis_Homo sapiens_hsa052040.61357487
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60622744
70mRNA surveillance pathway_Homo sapiens_hsa030150.58663879
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57635355
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53205984
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48499604
74Oocyte meiosis_Homo sapiens_hsa041140.47444561
75Type I diabetes mellitus_Homo sapiens_hsa049400.46619414
76Fatty acid metabolism_Homo sapiens_hsa012120.44944660
77Graft-versus-host disease_Homo sapiens_hsa053320.43267444
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43030318
79Olfactory transduction_Homo sapiens_hsa047400.43017812
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42280551
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41555926
82Asthma_Homo sapiens_hsa053100.40195404
83Regulation of autophagy_Homo sapiens_hsa041400.39228008
84Antigen processing and presentation_Homo sapiens_hsa046120.37867168
85Autoimmune thyroid disease_Homo sapiens_hsa053200.37734099
86Allograft rejection_Homo sapiens_hsa053300.36838856
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36066716
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.35536778
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34554667
90Galactose metabolism_Homo sapiens_hsa000520.33847200
91p53 signaling pathway_Homo sapiens_hsa041150.33135503
92Fat digestion and absorption_Homo sapiens_hsa049750.32142573
93Ether lipid metabolism_Homo sapiens_hsa005650.28038101
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27564897
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26887410
96Collecting duct acid secretion_Homo sapiens_hsa049660.26705032
97Hematopoietic cell lineage_Homo sapiens_hsa046400.26473419
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.26393011
99Epstein-Barr virus infection_Homo sapiens_hsa051690.24100201
100Rheumatoid arthritis_Homo sapiens_hsa053230.23911896

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