TERF2IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.44185348
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46171052
3vocalization behavior (GO:0071625)5.43166032
4establishment of mitochondrion localization (GO:0051654)5.36059191
5nucleobase catabolic process (GO:0046113)5.24707725
6synaptic vesicle exocytosis (GO:0016079)5.24244889
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07456335
8protein localization to synapse (GO:0035418)5.01334673
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81837262
10neuron cell-cell adhesion (GO:0007158)4.79160878
11response to pheromone (GO:0019236)4.70129982
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.68138840
13regulation of synaptic vesicle exocytosis (GO:2000300)4.65078047
14synaptic vesicle maturation (GO:0016188)4.57560483
15regulation of synaptic vesicle transport (GO:1902803)4.29190583
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.28566419
17regulation of glutamate receptor signaling pathway (GO:1900449)4.25653907
18glutamate receptor signaling pathway (GO:0007215)4.22537768
19glutamate secretion (GO:0014047)4.15492250
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15134865
21neurotransmitter secretion (GO:0007269)4.08862477
22locomotory exploration behavior (GO:0035641)4.07624089
23neuron recognition (GO:0008038)3.98527993
24synaptic vesicle endocytosis (GO:0048488)3.97210555
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.92291442
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92156643
27layer formation in cerebral cortex (GO:0021819)3.91563998
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.90429962
29mitochondrion transport along microtubule (GO:0047497)3.90429962
30positive regulation of synaptic transmission, GABAergic (GO:0032230)3.90190800
31synaptic transmission, glutamatergic (GO:0035249)3.86268217
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.85654340
33neurofilament cytoskeleton organization (GO:0060052)3.81226913
34neuron-neuron synaptic transmission (GO:0007270)3.77345985
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.76797220
36postsynaptic membrane organization (GO:0001941)3.76112921
37positive regulation of synapse maturation (GO:0090129)3.70536699
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.69838295
39exploration behavior (GO:0035640)3.66240979
40long-term memory (GO:0007616)3.66232421
41neuronal ion channel clustering (GO:0045161)3.62966328
42glycosphingolipid biosynthetic process (GO:0006688)3.61459544
43neurotransmitter-gated ion channel clustering (GO:0072578)3.60450925
44cell migration in hindbrain (GO:0021535)3.59881105
45neuronal action potential propagation (GO:0019227)3.59565943
46neurotransmitter transport (GO:0006836)3.56584912
47transmission of nerve impulse (GO:0019226)3.55881162
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.55844506
49regulation of neuronal synaptic plasticity (GO:0048168)3.55678998
50cellular potassium ion homeostasis (GO:0030007)3.55368837
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47706949
52dendritic spine morphogenesis (GO:0060997)3.47545420
53axonal fasciculation (GO:0007413)3.46831774
54positive regulation of membrane potential (GO:0045838)3.39891594
55synapse assembly (GO:0007416)3.39454383
56righting reflex (GO:0060013)3.38532323
57regulation of vesicle fusion (GO:0031338)3.37233741
58regulation of synapse structural plasticity (GO:0051823)3.33961576
59prepulse inhibition (GO:0060134)3.32582842
60regulation of synapse maturation (GO:0090128)3.32103453
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.31495178
62regulation of neurotransmitter secretion (GO:0046928)3.31233098
63positive regulation of mitochondrial fission (GO:0090141)3.30728975
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.30092999
65gamma-aminobutyric acid transport (GO:0015812)3.28371173
66regulation of postsynaptic membrane potential (GO:0060078)3.27795773
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.27240054
68response to auditory stimulus (GO:0010996)3.25240247
69response to histamine (GO:0034776)3.23778762
70regulation of synaptic transmission, GABAergic (GO:0032228)3.22543695
71mating behavior (GO:0007617)3.21886724
72sodium ion export (GO:0071436)3.17789989
73proline transport (GO:0015824)3.17277567
74regulation of neurotransmitter transport (GO:0051588)3.16791677
75cell communication by electrical coupling (GO:0010644)3.16594444
76dendritic spine organization (GO:0097061)3.15626713
77innervation (GO:0060384)3.15311271
78membrane hyperpolarization (GO:0060081)3.14299670
79establishment of synaptic vesicle localization (GO:0097480)3.14006344
80synaptic vesicle transport (GO:0048489)3.14006344
81regulation of neurotransmitter levels (GO:0001505)3.13860842
82long-term synaptic potentiation (GO:0060291)3.12870432
83response to dietary excess (GO:0002021)3.12631473
84negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11679332
85negative regulation of microtubule polymerization (GO:0031115)3.11545802
86presynaptic membrane assembly (GO:0097105)3.11428017
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11337907
88positive regulation of dendritic spine development (GO:0060999)3.09981724
89membrane depolarization during action potential (GO:0086010)3.09192369
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08909223
91organelle transport along microtubule (GO:0072384)3.08677015
92cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06751880
93striatum development (GO:0021756)3.06607400
94startle response (GO:0001964)3.06426817
95regulation of dendritic spine morphogenesis (GO:0061001)3.03921686
96positive regulation of amino acid transport (GO:0051957)3.03401881
97establishment of vesicle localization (GO:0051650)3.02529217
98positive regulation of synapse assembly (GO:0051965)3.00739850
99presynaptic membrane organization (GO:0097090)3.00587652
100central nervous system projection neuron axonogenesis (GO:0021952)2.99567490
101auditory behavior (GO:0031223)2.98174383
102regulation of feeding behavior (GO:0060259)2.97154092
103adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96815944
104learning (GO:0007612)2.96798667
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96296446
106neuromuscular synaptic transmission (GO:0007274)2.94968740
107regulation of synaptic plasticity (GO:0048167)2.94964438
108synaptic transmission (GO:0007268)2.92730549
109membrane depolarization (GO:0051899)2.92023480
110mechanosensory behavior (GO:0007638)2.90424885
111behavioral fear response (GO:0001662)2.88338559
112behavioral defense response (GO:0002209)2.88338559
113hippocampus development (GO:0021766)2.87677837
114cerebellar Purkinje cell differentiation (GO:0021702)2.87545045
115behavioral response to cocaine (GO:0048148)2.86536520
116neuromuscular process controlling posture (GO:0050884)2.85614046
117adult walking behavior (GO:0007628)2.85451414
118regulation of voltage-gated calcium channel activity (GO:1901385)2.84685675
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84498688
120dendrite morphogenesis (GO:0048813)2.82255367
121positive regulation of neurotransmitter secretion (GO:0001956)2.81345955
122synapse organization (GO:0050808)2.79270517
123protein localization to cilium (GO:0061512)2.78311434
124cerebellar granule cell differentiation (GO:0021707)2.77867481
125regulation of glutamate secretion (GO:0014048)2.73582635
126substrate-independent telencephalic tangential migration (GO:0021826)2.73102346
127substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.73102346
128positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70841168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78746862
2GBX2_23144817_ChIP-Seq_PC3_Human3.95019096
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12785150
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09601327
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97235677
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.85400923
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79111763
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70536993
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.68375267
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.66756590
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63431483
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.62109998
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59616501
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59288217
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59288217
16TAF15_26573619_Chip-Seq_HEK293_Human2.40208196
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39345056
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36974840
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.32658384
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31886650
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.30865071
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21482460
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.13493582
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13492520
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03334583
26AR_21572438_ChIP-Seq_LNCaP_Human2.02616808
27DROSHA_22980978_ChIP-Seq_HELA_Human2.01911560
28* REST_18959480_ChIP-ChIP_MESCs_Mouse2.00098324
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99828499
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94800408
31IGF1R_20145208_ChIP-Seq_DFB_Human1.93922277
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93545099
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.92766573
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86052612
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83152764
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81610857
37SMAD4_21799915_ChIP-Seq_A2780_Human1.79461436
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.77421747
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77099866
40P300_19829295_ChIP-Seq_ESCs_Human1.76402295
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73965443
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.73513592
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64596871
44RNF2_27304074_Chip-Seq_NSC_Mouse1.63888310
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54166531
46* FUS_26573619_Chip-Seq_HEK293_Human1.53306984
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52806622
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47646181
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45361515
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.43330351
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41536716
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.34876574
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.32649962
54AR_25329375_ChIP-Seq_VCAP_Human1.32530919
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30691433
56CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28658389
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27533902
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24951012
59VDR_22108803_ChIP-Seq_LS180_Human1.24189150
60STAT3_23295773_ChIP-Seq_U87_Human1.22000469
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20084200
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19909101
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17289987
64RUNX2_22187159_ChIP-Seq_PCA_Human1.15780744
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.15499577
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.15418631
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13910030
68TP53_22573176_ChIP-Seq_HFKS_Human1.13365425
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12529451
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11935425
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11477091
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11041611
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08995737
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08909832
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.08502292
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08178983
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07263202
78ZNF274_21170338_ChIP-Seq_K562_Hela1.05450836
79TCF4_23295773_ChIP-Seq_U87_Human1.04736255
80AR_19668381_ChIP-Seq_PC3_Human1.03723346
81ER_23166858_ChIP-Seq_MCF-7_Human1.02835436
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.01755509
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01666822
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99929792
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99361985
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99130797
87* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98722641
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98602559
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97832508
90* JUN_21703547_ChIP-Seq_K562_Human0.97722512
91YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96651180
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96575040
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95419094
94REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94868518
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94774807
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94650659
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.94299775
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.93522924
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.93211847
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.93030636
101SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92760997
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91979661
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91665394
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.91528357
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90920358
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90920358
107IRF1_19129219_ChIP-ChIP_H3396_Human0.90820278
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90679529
109CBP_20019798_ChIP-Seq_JUKART_Human0.90489604
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90489604
111BCAT_22108803_ChIP-Seq_LS180_Human0.89042090
112EWS_26573619_Chip-Seq_HEK293_Human0.88723598
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88322824
114P53_22387025_ChIP-Seq_ESCs_Mouse0.87895042
115CMYC_18555785_Chip-Seq_ESCs_Mouse0.87385646
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86413660
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85958997
118GATA1_26923725_Chip-Seq_HPCs_Mouse0.83935276
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82845537
120HTT_18923047_ChIP-ChIP_STHdh_Human0.80594788
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.80420952
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78978988
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78741413
124KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78571580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.94991030
2MP0004859_abnormal_synaptic_plasticity4.51832758
3MP0003635_abnormal_synaptic_transmissio3.49129578
4MP0005423_abnormal_somatic_nervous3.35542275
5MP0009745_abnormal_behavioral_response2.97009240
6MP0001968_abnormal_touch/_nociception2.93016214
7MP0002063_abnormal_learning/memory/cond2.79521280
8MP0006276_abnormal_autonomic_nervous2.69081753
9MP0002064_seizures2.64074950
10MP0009046_muscle_twitch2.60749131
11MP0004270_analgesia2.47096294
12MP0002572_abnormal_emotion/affect_behav2.45533811
13MP0001486_abnormal_startle_reflex2.43146338
14MP0003122_maternal_imprinting2.33780862
15MP0002272_abnormal_nervous_system2.32758928
16MP0003787_abnormal_imprinting2.31618117
17MP0002735_abnormal_chemical_nociception2.25334056
18MP0002734_abnormal_mechanical_nocicepti2.25197177
19* MP0001188_hyperpigmentation2.22132651
20MP0002736_abnormal_nociception_after2.21686185
21MP0005645_abnormal_hypothalamus_physiol2.17074234
22MP0005646_abnormal_pituitary_gland2.15424641
23MP0001529_abnormal_vocalization2.14021410
24MP0002184_abnormal_innervation2.08014188
25MP0000778_abnormal_nervous_system2.01656266
26MP0001501_abnormal_sleep_pattern2.00599681
27MP0006292_abnormal_olfactory_placode1.97554460
28MP0001984_abnormal_olfaction1.96692713
29MP0005551_abnormal_eye_electrophysiolog1.95448992
30MP0002067_abnormal_sensory_capabilities1.92771670
31MP0002557_abnormal_social/conspecific_i1.88577797
32MP0001502_abnormal_circadian_rhythm1.86940829
33MP0006072_abnormal_retinal_apoptosis1.86567355
34MP0002733_abnormal_thermal_nociception1.85753865
35MP0008877_abnormal_DNA_methylation1.85239021
36MP0001440_abnormal_grooming_behavior1.83706059
37MP0004924_abnormal_behavior1.79258374
38MP0005386_behavior/neurological_phenoty1.79258374
39MP0001970_abnormal_pain_threshold1.75080264
40MP0003121_genomic_imprinting1.67730676
41MP0002638_abnormal_pupillary_reflex1.58744381
42MP0008569_lethality_at_weaning1.56478971
43MP0004142_abnormal_muscle_tone1.53720029
44MP0001905_abnormal_dopamine_level1.51217596
45MP0004811_abnormal_neuron_physiology1.51110973
46MP0005394_taste/olfaction_phenotype1.51098401
47MP0005499_abnormal_olfactory_system1.51098401
48MP0000955_abnormal_spinal_cord1.49404912
49MP0003123_paternal_imprinting1.42665957
50MP0002882_abnormal_neuron_morphology1.41171688
51MP0002822_catalepsy1.40963234
52MP0002102_abnormal_ear_morphology1.37325729
53MP0002653_abnormal_ependyma_morphology1.31407799
54MP0000631_abnormal_neuroendocrine_gland1.25259268
55MP0002066_abnormal_motor_capabilities/c1.21415028
56MP0000566_synostosis1.19577232
57MP0005409_darkened_coat_color1.19435641
58MP0008789_abnormal_olfactory_epithelium1.17112159
59MP0004742_abnormal_vestibular_system1.14042888
60MP0002090_abnormal_vision1.10173682
61MP0005253_abnormal_eye_physiology1.09456537
62MP0004147_increased_porphyrin_level1.07860070
63MP0002752_abnormal_somatic_nervous1.07513121
64MP0009780_abnormal_chondrocyte_physiolo1.05881141
65MP0002909_abnormal_adrenal_gland1.04883029
66MP0000569_abnormal_digit_pigmentation1.02982385
67MP0004145_abnormal_muscle_electrophysio1.01950430
68MP0002152_abnormal_brain_morphology1.00913355
69MP0004858_abnormal_nervous_system1.00459628
70MP0010386_abnormal_urinary_bladder0.98552679
71MP0001346_abnormal_lacrimal_gland0.98360435
72MP0003879_abnormal_hair_cell0.96288968
73MP0002229_neurodegeneration0.94595080
74MP0001986_abnormal_taste_sensitivity0.93611668
75MP0005379_endocrine/exocrine_gland_phen0.93463244
76MP0002069_abnormal_eating/drinking_beha0.92863045
77MP0000604_amyloidosis0.91944188
78MP0005248_abnormal_Harderian_gland0.87964948
79MP0001963_abnormal_hearing_physiology0.87275319
80MP0008872_abnormal_physiological_respon0.86889376
81MP0003329_amyloid_beta_deposits0.86565497
82MP0002751_abnormal_autonomic_nervous0.85903233
83MP0003690_abnormal_glial_cell0.82738521
84MP0003633_abnormal_nervous_system0.80875536
85MP0001664_abnormal_digestion0.79861912
86MP0000920_abnormal_myelination0.78794678
87MP0001177_atelectasis0.78681065
88MP0005187_abnormal_penis_morphology0.76950615
89MP0003011_delayed_dark_adaptation0.76413332
90MP0004215_abnormal_myocardial_fiber0.75857086
91MP0000751_myopathy0.74543760
92MP0000026_abnormal_inner_ear0.74477939
93MP0002234_abnormal_pharynx_morphology0.72842578
94MP0003632_abnormal_nervous_system0.70976548
95MP0003631_nervous_system_phenotype0.68099928
96MP0004233_abnormal_muscle_weight0.67440599
97MP0005084_abnormal_gallbladder_morpholo0.67183363
98MP0002928_abnormal_bile_duct0.66384240
99MP0005195_abnormal_posterior_eye0.65848046
100MP0005167_abnormal_blood-brain_barrier0.65183126
101MP0003137_abnormal_impulse_conducting0.63116443
102MP0000639_abnormal_adrenal_gland0.62713689
103MP0008874_decreased_physiological_sensi0.61631557
104MP0004885_abnormal_endolymph0.61625205
105MP0001485_abnormal_pinna_reflex0.61129788
106MP0003861_abnormal_nervous_system0.60788287
107MP0002163_abnormal_gland_morphology0.60290746
108MP0002876_abnormal_thyroid_physiology0.60048785
109MP0003283_abnormal_digestive_organ0.58555936
110MP0003634_abnormal_glial_cell0.58378583
111MP0005535_abnormal_body_temperature0.56566977
112MP0003221_abnormal_cardiomyocyte_apopto0.55471401
113MP0001943_abnormal_respiration0.55395910
114MP0004085_abnormal_heartbeat0.54343696
115MP0008995_early_reproductive_senescence0.54128738
116MP0010769_abnormal_survival0.53010527
117MP0010768_mortality/aging0.52341897
118MP0010770_preweaning_lethality0.51507894

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.13025288
2Febrile seizures (HP:0002373)4.78959021
3Epileptic encephalopathy (HP:0200134)4.61205477
4Myokymia (HP:0002411)4.40384990
5Focal seizures (HP:0007359)4.34731279
6Visual hallucinations (HP:0002367)4.01275910
7Progressive cerebellar ataxia (HP:0002073)3.98310039
8Congenital stationary night blindness (HP:0007642)3.80391401
9Amyotrophic lateral sclerosis (HP:0007354)3.68735283
10Absence seizures (HP:0002121)3.48200754
11Peripheral hypomyelination (HP:0007182)3.43606726
12Spastic gait (HP:0002064)3.43331134
13Abnormality of the corticospinal tract (HP:0002492)3.43244537
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.36120028
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.36120028
16Generalized tonic-clonic seizures (HP:0002069)3.31249961
17Limb dystonia (HP:0002451)3.27306884
18Polyphagia (HP:0002591)3.24728199
19Atonic seizures (HP:0010819)3.18959629
20Dialeptic seizures (HP:0011146)3.13901874
21Gait imbalance (HP:0002141)3.11026402
22Severe visual impairment (HP:0001141)3.08472650
23Broad-based gait (HP:0002136)2.89254148
24Abnormal hair whorl (HP:0010721)2.87672207
25Progressive inability to walk (HP:0002505)2.83437028
26Mutism (HP:0002300)2.81689697
27Excessive salivation (HP:0003781)2.79877651
28Drooling (HP:0002307)2.79877651
29Spastic tetraplegia (HP:0002510)2.76603489
30Abnormal eating behavior (HP:0100738)2.73598131
31Ankle clonus (HP:0011448)2.72955716
32Aplasia/Hypoplasia of the brainstem (HP:0007362)2.71069672
33Hypoplasia of the brainstem (HP:0002365)2.71069672
34Retinal dysplasia (HP:0007973)2.69165578
35Medial flaring of the eyebrow (HP:0010747)2.68339598
36Fetal akinesia sequence (HP:0001989)2.68066484
37Congenital primary aphakia (HP:0007707)2.67572241
38Poor eye contact (HP:0000817)2.63469156
39Hyperventilation (HP:0002883)2.60996859
40Nephrogenic diabetes insipidus (HP:0009806)2.58619076
41Pachygyria (HP:0001302)2.56663727
42Atrophy/Degeneration involving motor neurons (HP:0007373)2.51887079
43Morphological abnormality of the pyramidal tract (HP:0002062)2.51041983
44Ulnar claw (HP:0001178)2.51014601
45Intention tremor (HP:0002080)2.48777332
46Supranuclear gaze palsy (HP:0000605)2.46767717
47Truncal ataxia (HP:0002078)2.46122740
48Central scotoma (HP:0000603)2.45857344
49Lissencephaly (HP:0001339)2.44384385
50Abnormality of the lower motor neuron (HP:0002366)2.43319590
51Hemiparesis (HP:0001269)2.42701304
52Action tremor (HP:0002345)2.42630792
53Status epilepticus (HP:0002133)2.41645521
54Anxiety (HP:0000739)2.40586994
55Absent speech (HP:0001344)2.37743197
56Epileptiform EEG discharges (HP:0011182)2.37190900
57Abnormality of macular pigmentation (HP:0008002)2.35183449
58Delusions (HP:0000746)2.34691467
59Gaze-evoked nystagmus (HP:0000640)2.34290652
60Esotropia (HP:0000565)2.31290824
61EEG with generalized epileptiform discharges (HP:0011198)2.29693977
62Poor suck (HP:0002033)2.26351100
63True hermaphroditism (HP:0010459)2.25890480
64Depression (HP:0000716)2.24085038
65Amblyopia (HP:0000646)2.22737803
66Genetic anticipation (HP:0003743)2.22658793
67Inability to walk (HP:0002540)2.21917977
68Urinary bladder sphincter dysfunction (HP:0002839)2.21194979
69Scanning speech (HP:0002168)2.18175889
70Type II lissencephaly (HP:0007260)2.17786504
71Cerebral hypomyelination (HP:0006808)2.16190870
72Abnormal ciliary motility (HP:0012262)2.15141374
73Dysdiadochokinesis (HP:0002075)2.14837274
74Genital tract atresia (HP:0001827)2.14812433
75Cortical dysplasia (HP:0002539)2.13443213
76Hypoplasia of the corpus callosum (HP:0002079)2.12861250
77Papilledema (HP:0001085)2.12628028
78Vaginal atresia (HP:0000148)2.11987782
79Pancreatic fibrosis (HP:0100732)2.11479200
80Agitation (HP:0000713)2.10503713
81Septo-optic dysplasia (HP:0100842)2.10368482
82Specific learning disability (HP:0001328)2.10351168
83Abnormal social behavior (HP:0012433)2.10292733
84Impaired social interactions (HP:0000735)2.10292733
85Megalencephaly (HP:0001355)2.10026728
86Postural instability (HP:0002172)2.08947202
87Sleep apnea (HP:0010535)2.07172730
88Abnormality of salivation (HP:0100755)2.06598747
89Protruding tongue (HP:0010808)2.05646405
90Abnormality of the labia minora (HP:0012880)2.04725321
91Akinesia (HP:0002304)2.03298682
92Hypsarrhythmia (HP:0002521)2.02084299
93Muscular hypotonia of the trunk (HP:0008936)1.99151769
94Narrow nasal bridge (HP:0000446)1.98236597
95Decreased central vision (HP:0007663)1.94238433
96Neurofibrillary tangles (HP:0002185)1.94174665
97Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93537835
98Failure to thrive in infancy (HP:0001531)1.91142104
99Dysmetria (HP:0001310)1.90856612
100Split foot (HP:0001839)1.90038421
101Torticollis (HP:0000473)1.89987241
102Generalized hypopigmentation of hair (HP:0011358)1.89891788
103Neuronal loss in central nervous system (HP:0002529)1.88279584
104Paraplegia (HP:0010550)1.87902300
105Clonus (HP:0002169)1.87611292
106Intellectual disability, severe (HP:0010864)1.86701858
107Impaired vibration sensation in the lower limbs (HP:0002166)1.86624449
108Poor coordination (HP:0002370)1.86441989
109Hypothermia (HP:0002045)1.85411125
110Abnormality of binocular vision (HP:0011514)1.84625318
111Diplopia (HP:0000651)1.84625318
112Optic nerve hypoplasia (HP:0000609)1.84284355
113Generalized myoclonic seizures (HP:0002123)1.83220417
114Urinary urgency (HP:0000012)1.82259310
115Dynein arm defect of respiratory motile cilia (HP:0012255)1.81700259
116Absent/shortened dynein arms (HP:0200106)1.81700259
117Bradykinesia (HP:0002067)1.80166926
118CNS hypomyelination (HP:0003429)1.79568132
119Fair hair (HP:0002286)1.79337451
120Dyskinesia (HP:0100660)1.79180061
121Abnormal EKG (HP:0003115)1.75174003
122Molar tooth sign on MRI (HP:0002419)1.72150384
123Abnormality of midbrain morphology (HP:0002418)1.72150384
124Abnormal respiratory motile cilium physiology (HP:0012261)1.70076839
125Abnormal respiratory epithelium morphology (HP:0012253)1.68990241
126Abnormal respiratory motile cilium morphology (HP:0005938)1.68990241
127Incomplete penetrance (HP:0003829)1.68157378
128Focal dystonia (HP:0004373)1.67941713
129Generalized hypopigmentation (HP:0007513)1.67092802
130Psychosis (HP:0000709)1.66261322
131Lower limb muscle weakness (HP:0007340)1.66097980
132Blue irides (HP:0000635)1.65948000
133Thickened helices (HP:0000391)1.65725257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.95817365
2MARK13.87550855
3EPHA43.61789743
4CASK3.11881753
5MAP3K93.08273069
6MAP2K73.07546351
7MAP3K42.93872624
8MAP3K122.83617012
9MINK12.72038905
10TNIK2.46827732
11MAPK132.45988031
12MAP4K22.12281899
13NTRK22.03082486
14DAPK21.76260750
15TRIM281.70869711
16ARAF1.70132408
17PNCK1.65930075
18RIPK41.49413605
19MAP3K131.46390028
20BMPR1B1.44893199
21PAK61.42415921
22KSR11.41495094
23SIK31.36312218
24PLK21.36225046
25MAP3K111.35394052
26MAP2K41.35091945
27CDK51.29956444
28TESK11.29925577
29EPHA31.28944436
30STK161.27892525
31SGK2231.26343515
32SGK4941.26343515
33PINK11.24960474
34IRAK21.23958939
35DYRK1A1.23896849
36PHKG21.23827481
37PHKG11.23827481
38PRKCG1.20878943
39ERBB31.20288723
40DAPK11.20202631
41SGK21.20107872
42NME11.19372663
43BMPR21.19175127
44CSNK1A1L1.18830770
45BCKDK1.16739442
46LIMK11.15078398
47FES1.14421621
48SIK21.09376477
49DYRK31.05011516
50CSNK1G11.02680894
51DYRK1B1.02434087
52CDK81.01531885
53CAMK2A1.01312498
54GRK50.98173603
55TESK20.97026261
56LATS20.96249913
57ADRBK20.94690837
58CDK190.94419291
59TNK20.92977728
60WNK30.92773886
61UHMK10.91408466
62STK380.89853394
63CDK140.87228895
64NTRK10.85848937
65PRPF4B0.85171383
66CAMKK20.83753635
67CSNK1G20.81964369
68NEK60.80078148
69CDK180.79919660
70CAMKK10.79442046
71TAOK30.78703506
72CAMK40.77052714
73AKT30.77051048
74CAMK2B0.76637146
75TAOK10.73465871
76CDK150.73156385
77BRAF0.72395300
78PRKCE0.69658160
79CDK11A0.67175777
80MAPKAPK50.64804686
81MAP3K50.64616219
82CDK30.63722991
83PRKCZ0.62743398
84BRD40.62404699
85BCR0.62370558
86SGK30.61659511
87IRAK10.59924155
88GRK70.59016080
89CAMK10.57890837
90FER0.57286332
91CAMK2G0.56842313
92SGK10.54793624
93RPS6KA40.54686097
94KSR20.54028413
95PRKD30.52824538
96PIM20.52580875
97DYRK20.51874135
98MAPK120.51198308
99CAMK2D0.50032839
100PAK30.49503548
101PRKAA10.49335922
102BRSK10.48935790
103TYRO30.45674470
104GRK10.45651685
105ADRBK10.43655944
106STK110.43227432
107RPS6KA50.41290029
108CSNK1G30.41253912
109PRKACA0.41053316
110CSNK1D0.40180211
111PRKCH0.40078423
112RAF10.39739325
113RPS6KA20.39332708
114MAPK100.38091001
115MAPK90.37789403
116FYN0.37683936
117CSNK1A10.37428604
118PRKG10.37340283
119VRK10.37285799
120MAP3K60.36334863
121PKN10.36082425
122MUSK0.34264429
123CSNK1E0.33530495
124PLK30.31484623
125RPS6KA30.31186130
126OXSR10.30942447
127MARK20.30378018
128PRKD10.29016839

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.61244706
2Synaptic vesicle cycle_Homo sapiens_hsa047213.54234005
3GABAergic synapse_Homo sapiens_hsa047273.03753440
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.93241407
5Morphine addiction_Homo sapiens_hsa050322.92568268
6Olfactory transduction_Homo sapiens_hsa047402.80940397
7Circadian entrainment_Homo sapiens_hsa047132.75765435
8Glutamatergic synapse_Homo sapiens_hsa047242.49590827
9Amphetamine addiction_Homo sapiens_hsa050312.37344808
10Long-term potentiation_Homo sapiens_hsa047202.27907993
11Dopaminergic synapse_Homo sapiens_hsa047282.17719951
12Taste transduction_Homo sapiens_hsa047422.14365766
13Salivary secretion_Homo sapiens_hsa049702.12475132
14Insulin secretion_Homo sapiens_hsa049112.11356093
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06634610
16Serotonergic synapse_Homo sapiens_hsa047262.06389807
17Phototransduction_Homo sapiens_hsa047442.05407180
18Cocaine addiction_Homo sapiens_hsa050301.87104991
19Cholinergic synapse_Homo sapiens_hsa047251.83820793
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77803536
21Calcium signaling pathway_Homo sapiens_hsa040201.74791575
22Renin secretion_Homo sapiens_hsa049241.74368862
23Collecting duct acid secretion_Homo sapiens_hsa049661.70997252
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65145060
25Long-term depression_Homo sapiens_hsa047301.64136680
26Gastric acid secretion_Homo sapiens_hsa049711.52837795
27Oxytocin signaling pathway_Homo sapiens_hsa049211.50953356
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47232997
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39465380
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38828309
31Cardiac muscle contraction_Homo sapiens_hsa042601.30728892
32Gap junction_Homo sapiens_hsa045401.23636574
33Axon guidance_Homo sapiens_hsa043601.20821729
34cAMP signaling pathway_Homo sapiens_hsa040241.19058365
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18512010
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17912397
37Butanoate metabolism_Homo sapiens_hsa006501.09948121
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09391885
39GnRH signaling pathway_Homo sapiens_hsa049121.07948509
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04880408
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04760767
42Melanogenesis_Homo sapiens_hsa049161.02790897
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99606870
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99439442
45Circadian rhythm_Homo sapiens_hsa047100.98565311
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95693281
47Vibrio cholerae infection_Homo sapiens_hsa051100.95416353
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92795690
49Protein export_Homo sapiens_hsa030600.88598169
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85274497
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84845167
52Oocyte meiosis_Homo sapiens_hsa041140.83717158
53Oxidative phosphorylation_Homo sapiens_hsa001900.80554881
54Alzheimers disease_Homo sapiens_hsa050100.77542774
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.77144855
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76864194
57Type II diabetes mellitus_Homo sapiens_hsa049300.76817339
58ErbB signaling pathway_Homo sapiens_hsa040120.76165639
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75112378
60Estrogen signaling pathway_Homo sapiens_hsa049150.74866878
61Phagosome_Homo sapiens_hsa041450.73913855
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73899603
63Alcoholism_Homo sapiens_hsa050340.73146353
64Pancreatic secretion_Homo sapiens_hsa049720.72934489
65MAPK signaling pathway_Homo sapiens_hsa040100.72896823
66Parkinsons disease_Homo sapiens_hsa050120.72621329
67Regulation of autophagy_Homo sapiens_hsa041400.72418468
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70915248
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66617142
70Wnt signaling pathway_Homo sapiens_hsa043100.64481860
71Dilated cardiomyopathy_Homo sapiens_hsa054140.61033718
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59687323
73Salmonella infection_Homo sapiens_hsa051320.58787527
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58588242
75Choline metabolism in cancer_Homo sapiens_hsa052310.57581850
76Ether lipid metabolism_Homo sapiens_hsa005650.57521823
77Ras signaling pathway_Homo sapiens_hsa040140.56953617
78Glioma_Homo sapiens_hsa052140.56157977
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55443940
80Steroid biosynthesis_Homo sapiens_hsa001000.54976865
81Thyroid hormone synthesis_Homo sapiens_hsa049180.54478468
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51623823
83AMPK signaling pathway_Homo sapiens_hsa041520.51363094
84Inositol phosphate metabolism_Homo sapiens_hsa005620.51097630
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.50970620
86Type I diabetes mellitus_Homo sapiens_hsa049400.47834178
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47493551
88Huntingtons disease_Homo sapiens_hsa050160.44814518
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.43459046
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.41304190
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40085544
92Hedgehog signaling pathway_Homo sapiens_hsa043400.39586190
93Rap1 signaling pathway_Homo sapiens_hsa040150.35620510
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35573126
95Colorectal cancer_Homo sapiens_hsa052100.34607285
96African trypanosomiasis_Homo sapiens_hsa051430.33023836
97Glucagon signaling pathway_Homo sapiens_hsa049220.32730797
98Rheumatoid arthritis_Homo sapiens_hsa053230.32306334
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32039755
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31882402
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30886276
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30822167
103Chemokine signaling pathway_Homo sapiens_hsa040620.29175902
104Fatty acid elongation_Homo sapiens_hsa000620.28532809
105beta-Alanine metabolism_Homo sapiens_hsa004100.28475705
106Shigellosis_Homo sapiens_hsa051310.26856883
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26703511
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26504583
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25947738
110Endocytosis_Homo sapiens_hsa041440.25786038
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24801084
112Endometrial cancer_Homo sapiens_hsa052130.22701787
113Dorso-ventral axis formation_Homo sapiens_hsa043200.21942742
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19695691
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19190665
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.17875721
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17434353
118Renal cell carcinoma_Homo sapiens_hsa052110.17070911
119Prion diseases_Homo sapiens_hsa050200.16694391
120Purine metabolism_Homo sapiens_hsa002300.16546062
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15904552
122Ovarian steroidogenesis_Homo sapiens_hsa049130.15813986
123Autoimmune thyroid disease_Homo sapiens_hsa053200.15612037
124Mineral absorption_Homo sapiens_hsa049780.15582750
125Insulin signaling pathway_Homo sapiens_hsa049100.15031754

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »