TESC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.69435521
2gas transport (GO:0015669)5.13525203
3positive regulation of gamma-delta T cell activation (GO:0046645)5.01471499
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.99533713
5protoporphyrinogen IX biosynthetic process (GO:0006782)4.96627528
6neutrophil activation involved in immune response (GO:0002283)4.90195771
7negative regulation of hormone metabolic process (GO:0032351)4.80585553
8negative regulation of hormone biosynthetic process (GO:0032353)4.80585553
9negative regulation of potassium ion transmembrane transport (GO:1901380)4.64772782
10modulation by symbiont of host defense response (GO:0052031)4.60302575
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.60302575
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.60302575
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.60302575
14modulation by symbiont of host immune response (GO:0052553)4.60302575
15positive regulation by symbiont of host defense response (GO:0052509)4.60302575
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55294709
17negative regulation of cell killing (GO:0031342)4.55294709
18regulation of membrane repolarization (GO:0060306)4.50414671
19regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.48412647
20hemoglobin metabolic process (GO:0020027)4.47992280
21cardiac myofibril assembly (GO:0055003)4.38669777
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32977137
23negative regulation of erythrocyte differentiation (GO:0045647)4.30370457
24response to peptidoglycan (GO:0032494)4.28855254
25detection of bacterium (GO:0016045)4.20245854
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.19505982
27detection of other organism (GO:0098543)4.18345695
28sarcomere organization (GO:0045214)4.15833802
29regulation of B cell receptor signaling pathway (GO:0050855)4.14039408
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.13129030
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09785692
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.06585356
33regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.97271046
34ventricular cardiac muscle cell action potential (GO:0086005)3.95806981
35antigen processing and presentation of endogenous antigen (GO:0019883)3.94359306
36porphyrin-containing compound biosynthetic process (GO:0006779)3.93173078
37regulation of meiosis (GO:0040020)3.91372208
38cell communication involved in cardiac conduction (GO:0086065)3.84955843
39heme biosynthetic process (GO:0006783)3.84706164
40erythrocyte development (GO:0048821)3.83879472
41cardiac muscle contraction (GO:0060048)3.83390849
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.83041956
43regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.80438395
44regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.80199963
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.78227023
46leukocyte aggregation (GO:0070486)3.74471645
47erythrocyte maturation (GO:0043249)3.73920611
48cellular extravasation (GO:0045123)3.72587375
49potassium ion export (GO:0071435)3.71467226
50macrophage activation involved in immune response (GO:0002281)3.67643387
51myofibril assembly (GO:0030239)3.65630033
52detection of calcium ion (GO:0005513)3.63492898
53respiratory burst (GO:0045730)3.63122114
54regulation of relaxation of muscle (GO:1901077)3.62769573
55regulation of mast cell degranulation (GO:0043304)3.56292490
56regulation of meiosis I (GO:0060631)3.55722985
57cardiac muscle cell development (GO:0055013)3.54249491
58positive regulation of B cell differentiation (GO:0045579)3.53428857
59cell communication by electrical coupling (GO:0010644)3.52046931
60regulation of cell communication by electrical coupling (GO:0010649)3.49819632
61regulation of glucocorticoid metabolic process (GO:0031943)3.46135602
62modulation by virus of host process (GO:0019054)3.45169579
63regulation of gamma-delta T cell activation (GO:0046643)3.45115414
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.44789166
65immunoglobulin mediated immune response (GO:0016064)3.43519727
66neutrophil mediated immunity (GO:0002446)3.43463703
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.43301577
68porphyrin-containing compound metabolic process (GO:0006778)3.42002899
69regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.39733845
70regulation of synapse structural plasticity (GO:0051823)3.38981835
71negative regulation of interleukin-12 production (GO:0032695)3.38428718
72detection of external biotic stimulus (GO:0098581)3.37967492
73neutrophil activation (GO:0042119)3.37564566
74tetrapyrrole biosynthetic process (GO:0033014)3.37055103
75B cell receptor signaling pathway (GO:0050853)3.36820313
76tricarboxylic acid cycle (GO:0006099)3.36349785
77heme metabolic process (GO:0042168)3.36083662
78negative regulation of phagocytosis (GO:0050765)3.35876753
79regulation of short-term neuronal synaptic plasticity (GO:0048172)3.35791155
80regulation of acyl-CoA biosynthetic process (GO:0050812)3.35659611
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33124663
82cardiac muscle cell action potential involved in contraction (GO:0086002)3.30557704
83cardiac cell development (GO:0055006)3.28372115
84myeloid cell activation involved in immune response (GO:0002275)3.27851566
85leukocyte degranulation (GO:0043299)3.27449277
86leukocyte migration involved in inflammatory response (GO:0002523)3.27095163
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26882829
88response to host immune response (GO:0052572)3.26654414
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26654414
90regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.26612564
91regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.26612564
92synaptic vesicle maturation (GO:0016188)3.24034207
93positive regulation of potassium ion transmembrane transport (GO:1901381)3.23876806
94cardiac muscle cell action potential (GO:0086001)3.23189716
95cardiac conduction (GO:0061337)3.23049767
96regulation of mast cell activation involved in immune response (GO:0033006)3.21820616
97myeloid cell development (GO:0061515)3.21333834
98granulocyte activation (GO:0036230)3.21149251
99response to interleukin-15 (GO:0070672)3.20766348
100negative regulation of cytosolic calcium ion concentration (GO:0051481)3.20310334
101neuronal action potential propagation (GO:0019227)3.19403287
102regulation of gamma-delta T cell differentiation (GO:0045586)3.19054035
103regulation of actin filament-based movement (GO:1903115)3.18749555
104striatum development (GO:0021756)3.17591059
105negative regulation of lymphocyte mediated immunity (GO:0002707)3.17078590
106synaptic vesicle exocytosis (GO:0016079)3.16355782
107regulation of heart rate by cardiac conduction (GO:0086091)3.16305444
108positive thymic T cell selection (GO:0045059)3.14854602
109plasma membrane repair (GO:0001778)3.14810145
110regulation of leukocyte degranulation (GO:0043300)3.13613114
111regulation of meiotic cell cycle (GO:0051445)3.12472475
112regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12372219
113negative regulation of potassium ion transport (GO:0043267)3.09964805
1143-UTR-mediated mRNA stabilization (GO:0070935)3.09097720
115activation of protein kinase A activity (GO:0034199)3.08290245
116regulation of cardioblast differentiation (GO:0051890)3.06696501
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06278088
118regulation of interferon-beta biosynthetic process (GO:0045357)3.05480369
119regulation of synaptic vesicle transport (GO:1902803)3.05082746
120regulation of B cell differentiation (GO:0045577)3.04162022
121modulation by symbiont of host cellular process (GO:0044068)3.02421568
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.00549245
123response to muramyl dipeptide (GO:0032495)2.99257988
124regulation of coenzyme metabolic process (GO:0051196)2.99026236
125regulation of cofactor metabolic process (GO:0051193)2.99026236
126regulation of response to osmotic stress (GO:0047484)2.98259412
127megakaryocyte development (GO:0035855)2.97118545
128microglial cell activation (GO:0001774)2.96782607
129ventricular cardiac muscle cell development (GO:0055015)2.95937912
130detection of biotic stimulus (GO:0009595)2.95841936
131oxygen transport (GO:0015671)2.94653843
132macrophage activation (GO:0042116)2.94170289
133* positive regulation of sodium ion transport (GO:0010765)2.91678186
134response to host defenses (GO:0052200)2.91350353
135response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91350353
136response to host (GO:0075136)2.91350353
137relaxation of cardiac muscle (GO:0055119)2.91199057
138negative regulation of leukocyte mediated immunity (GO:0002704)2.90369637
139regulation of calcium ion transmembrane transporter activity (GO:1901019)2.90252412
140regulation of calcium ion transmembrane transport (GO:1903169)2.90252412
141negative regulation of meiosis (GO:0045835)2.90105723
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89228391
143positive regulation of vesicle fusion (GO:0031340)2.88038725
144regulation of mast cell activation (GO:0033003)2.87556296
145positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87211207
146disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.86767228
147killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.86767228
148synaptic vesicle docking involved in exocytosis (GO:0016081)2.84482811
149regulation of platelet aggregation (GO:0090330)2.83429469
150neuromuscular process controlling posture (GO:0050884)2.82777832
151myeloid leukocyte mediated immunity (GO:0002444)2.81579222
152vocalization behavior (GO:0071625)2.81037337
153regulation of female gonad development (GO:2000194)2.80855059
154negative regulation of calcium ion transmembrane transport (GO:1903170)2.78888351
155negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.78888351
156striated muscle contraction (GO:0006941)2.78771807
157detection of molecule of bacterial origin (GO:0032490)2.78685770
158glutamate secretion (GO:0014047)2.78460034
159heart trabecula formation (GO:0060347)2.78117208
160positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.77925507
161bundle of His cell to Purkinje myocyte communication (GO:0086069)2.77616232
162lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73677803
163positive regulation of mast cell activation (GO:0033005)2.73370379
164regulation of regulated secretory pathway (GO:1903305)2.72398121
165cellular response to interleukin-15 (GO:0071350)2.71895182
166membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.71591798
167regulation of superoxide anion generation (GO:0032928)2.71432081
168sarcoplasmic reticulum calcium ion transport (GO:0070296)2.71239644
169positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71091428
170sodium ion export (GO:0071436)2.70773135
171B cell mediated immunity (GO:0019724)2.70261373
172negative regulation of T cell mediated immunity (GO:0002710)2.70190519
173positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.69902811
174regulation of neuronal synaptic plasticity (GO:0048168)2.69320598
175membrane repolarization (GO:0086009)2.68870955
176G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68581522
177regulation of heart rate (GO:0002027)2.68218829
178synaptic transmission, dopaminergic (GO:0001963)2.68200545
179regulation of neurotransmitter uptake (GO:0051580)2.67911993
180regulation of cation channel activity (GO:2001257)2.67146413
181T cell migration (GO:0072678)2.66794408
182regulation of cardiac muscle cell contraction (GO:0086004)2.66208019
183* regulation of sodium ion transmembrane transporter activity (GO:2000649)2.65717666
184GDP-mannose metabolic process (GO:0019673)2.65375888
185* regulation of sodium ion transmembrane transport (GO:1902305)2.63792450
186negative regulation of cAMP-mediated signaling (GO:0043951)2.63507716
187regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.63460803
188positive regulation of potassium ion transport (GO:0043268)2.63119228
189cellular response to virus (GO:0098586)2.62899132
190regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62587849
191regulation of synaptic vesicle exocytosis (GO:2000300)2.62576891
192positive T cell selection (GO:0043368)2.61959946
193piRNA metabolic process (GO:0034587)2.61185460
194oocyte maturation (GO:0001556)2.61158219
195neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61124140
196regulation of voltage-gated calcium channel activity (GO:1901385)2.61068703
197negative regulation of cytokine production involved in immune response (GO:0002719)2.59840924
198defense response to protozoan (GO:0042832)2.58685176
199negative regulation of interleukin-6 production (GO:0032715)2.58060895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.53550294
2* VDR_21846776_ChIP-Seq_THP-1_Human3.47925132
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.33526167
4MYC_22102868_ChIP-Seq_BL_Human2.99623556
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.95858874
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.91058702
7SCL_19346495_ChIP-Seq_HPC-7_Human2.90617462
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.89348571
9GATA1_22025678_ChIP-Seq_K562_Human2.81837096
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.81649954
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64926011
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56203094
13VDR_24763502_ChIP-Seq_THP-1_Human2.55305741
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.52429488
15* GATA1_19941826_ChIP-Seq_K562_Human2.44813067
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43441988
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31482083
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.25123793
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24999567
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23648616
21MAF_26560356_Chip-Seq_TH1_Human2.19412333
22SPI1_23547873_ChIP-Seq_NB4_Human2.17585719
23GATA1_19941827_ChIP-Seq_MEL_Mouse2.15928116
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15681623
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13912892
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12981635
27* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12973987
28TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.11365619
29UTX_26944678_Chip-Seq_JUKART_Human2.10502270
30* TCF7_22412390_ChIP-Seq_EML_Mouse2.08477379
31GBX2_23144817_ChIP-Seq_PC3_Human2.06240004
32IRF8_21731497_ChIP-ChIP_J774_Mouse2.05571719
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05143982
34ESR1_20079471_ChIP-ChIP_T-47D_Human2.04698828
35* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99883985
36* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99883985
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99506970
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.99014836
39SPI1_23127762_ChIP-Seq_K562_Human1.97224338
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96468874
41* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95085099
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94821421
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94208196
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93695121
45LXR_22292898_ChIP-Seq_THP-1_Human1.93333314
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91962100
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91400221
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91061855
49* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90805737
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90747352
51* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89924896
52* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89044754
53REST_21632747_ChIP-Seq_MESCs_Mouse1.88206765
54* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.82910186
55* KDM2B_26808549_Chip-Seq_DND41_Human1.81847697
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79083261
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78490496
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77419641
59MAF_26560356_Chip-Seq_TH2_Human1.77117412
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.76484230
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.72136426
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71408705
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.71095248
64MYB_26560356_Chip-Seq_TH2_Human1.70245756
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.67195364
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.65095778
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63327076
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.63202226
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.62519425
70DROSHA_22980978_ChIP-Seq_HELA_Human1.62399382
71* RNF2_27304074_Chip-Seq_ESCs_Mouse1.61923327
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.61893053
73GATA1_26923725_Chip-Seq_HPCs_Mouse1.61465400
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.60917607
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59940720
76MYB_26560356_Chip-Seq_TH1_Human1.59602328
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59475285
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58890503
79* GATA2_19941826_ChIP-Seq_K562_Human1.58790580
80BCL6_27268052_Chip-Seq_Bcells_Human1.58389333
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58201966
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57369904
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56350218
84* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56063693
85BCOR_27268052_Chip-Seq_Bcells_Human1.55690104
86* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55596962
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53505458
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.53303880
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52617512
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.52260349
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50768426
92NCOR1_26117541_ChIP-Seq_K562_Human1.50468542
93* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45288234
94SMAD4_21799915_ChIP-Seq_A2780_Human1.44221889
95* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43683080
96P68_20966046_ChIP-Seq_HELA_Human1.43596291
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43250306
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42851885
99* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41727812
100RUNX_20019798_ChIP-Seq_JUKART_Human1.40801449
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40309851
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39714626
103ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39424988
104AR_21572438_ChIP-Seq_LNCaP_Human1.39355143
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38279373
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37137612
107ZNF263_19887448_ChIP-Seq_K562_Human1.36732597
108* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32644715
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32553327
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32378080
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31970510
112PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30050608
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29477968
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25614553
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24732216
116TBX20_22080862_ChIP-Seq_HEART_Mouse1.22923367
117TBX20_22328084_ChIP-Seq_HEART_Mouse1.22923367
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22392959
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21315454
120GATA3_27048872_Chip-Seq_THYMUS_Human1.21163847
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19311326
122RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19204463
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19191232
124* STAT3_23295773_ChIP-Seq_U87_Human1.18977500
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18099053
126FLI1_27457419_Chip-Seq_LIVER_Mouse1.16727428
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16167438
128SA1_27219007_Chip-Seq_ERYTHROID_Human1.16143571
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15615788
130RACK7_27058665_Chip-Seq_MCF-7_Human1.15067653
131CIITA_25753668_ChIP-Seq_RAJI_Human1.14749665
132CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14462595
133VDR_22108803_ChIP-Seq_LS180_Human1.13298630
134* KDM2B_26808549_Chip-Seq_K562_Human1.12771215
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.12415235
136SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12175921
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11937169
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11285011
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10798696
140SOX2_21211035_ChIP-Seq_LN229_Gbm1.10741373
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09592369
142* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09501494
143* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07674250
144KDM2B_26808549_Chip-Seq_JURKAT_Human1.06360396
145WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06145033
146RXR_22158963_ChIP-Seq_LIVER_Mouse1.05680077
147* AR_25329375_ChIP-Seq_VCAP_Human1.05266313
148MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05186288
149IGF1R_20145208_ChIP-Seq_DFB_Human1.05021468
150CTCF_27219007_Chip-Seq_Bcells_Human1.04580443
151TET1_21451524_ChIP-Seq_MESCs_Mouse1.04515610
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04303615
153CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04218584
154TET1_21490601_ChIP-Seq_MESCs_Mouse1.04153446
155CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03530479
156* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03208915
157* SMAD3_21741376_ChIP-Seq_HESCs_Human1.02822062
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02820787
159TAF15_26573619_Chip-Seq_HEK293_Human1.01024058
160CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00352024
161PHF8_20622854_ChIP-Seq_HELA_Human1.00247597
162SPI1_20517297_ChIP-Seq_HL60_Human0.99839698
163PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99791859
164* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98180368
165YY1_22570637_ChIP-Seq_MALME-3M_Human0.97002268
166GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96870189
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96821441
168RNF2_27304074_Chip-Seq_NSC_Mouse0.96488341
169* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95432848
170ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94397920
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94276319
172* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93583192
173P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92922619
174TBL1_22424771_ChIP-Seq_293T_Human0.91813740
175GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91269888
176AR_19668381_ChIP-Seq_PC3_Human0.91161494
177DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90648802
178BCAT_22108803_ChIP-Seq_LS180_Human0.90044706
179ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89445908
180ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88405225
181SMAD4_21741376_ChIP-Seq_EPCs_Human0.88321156
182AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87941215
183UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87801881
184TCF4_23295773_ChIP-Seq_U87_Human0.87696531
185ESR2_21235772_ChIP-Seq_MCF-7_Human0.87662164
186PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87601887
187AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87035643
188BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86058475
189RXR_22108803_ChIP-Seq_LS180_Human0.85802110
190* SMAD4_21741376_ChIP-Seq_HESCs_Human0.85757678
191FLI1_21867929_ChIP-Seq_TH2_Mouse0.85465560
192TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85115058
193POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84867892
194* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84618095
195* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84618095
196OCT1_27270436_Chip-Seq_PROSTATE_Human0.84166371
197GATA3_21867929_ChIP-Seq_TH1_Mouse0.83049458
198* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82964355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.68644940
2MP0002822_catalepsy4.39161257
3MP0002837_dystrophic_cardiac_calcinosis4.32069154
4MP0003656_abnormal_erythrocyte_physiolo4.12088021
5MP0004859_abnormal_synaptic_plasticity3.95594267
6MP0003436_decreased_susceptibility_to3.61753004
7MP0003303_peritoneal_inflammation3.53896040
8MP0004084_abnormal_cardiac_muscle3.37561847
9MP0000751_myopathy3.28381367
10MP0004215_abnormal_myocardial_fiber3.21121843
11MP0005451_abnormal_body_composition2.90236018
12MP0004036_abnormal_muscle_relaxation2.79052364
13MP0005464_abnormal_platelet_physiology2.77613026
14MP0004147_increased_porphyrin_level2.77510325
15MP0002419_abnormal_innate_immunity2.72380934
16MP0003724_increased_susceptibility_to2.71095613
17MP0001835_abnormal_antigen_presentation2.63227395
18MP0004510_myositis2.61094705
19MP0005025_abnormal_response_to2.60730249
20MP0003172_abnormal_lysosome_physiology2.60068933
21MP0000685_abnormal_immune_system2.57129020
22MP0005671_abnormal_response_to2.44585603
23MP0009785_altered_susceptibility_to2.43191725
24MP0003880_abnormal_central_pattern2.43189266
25MP0003635_abnormal_synaptic_transmissio2.41059073
26MP0005083_abnormal_biliary_tract2.37323572
27MP0005000_abnormal_immune_tolerance2.35145225
28MP0001800_abnormal_humoral_immune2.33023839
29MP0004484_altered_response_of2.32618896
30MP0004270_analgesia2.29758049
31MP0001529_abnormal_vocalization2.29555833
32MP0001545_abnormal_hematopoietic_system2.28537114
33MP0005397_hematopoietic_system_phenotyp2.28537114
34MP0008260_abnormal_autophagy2.28412150
35MP0001790_abnormal_immune_system2.27661230
36MP0005387_immune_system_phenotype2.27661230
37MP0002420_abnormal_adaptive_immunity2.22441222
38MP0001819_abnormal_immune_cell2.18599562
39MP0002132_abnormal_respiratory_system2.17242795
40MP0002723_abnormal_immune_serum2.12454424
41MP0002398_abnormal_bone_marrow2.10384829
42MP0009333_abnormal_splenocyte_physiolog2.08504791
43MP0005330_cardiomyopathy2.04620640
44MP0002396_abnormal_hematopoietic_system2.03127998
45MP0002452_abnormal_antigen_presenting2.02711900
46MP0002972_abnormal_cardiac_muscle2.01660159
47MP0003763_abnormal_thymus_physiology2.01193702
48MP0002102_abnormal_ear_morphology2.00990843
49MP0009278_abnormal_bone_marrow1.99595234
50MP0003300_gastrointestinal_ulcer1.98316744
51MP0005058_abnormal_lysosome_morphology1.97243467
52MP0002063_abnormal_learning/memory/cond1.89435072
53MP0003137_abnormal_impulse_conducting1.88784473
54MP0009745_abnormal_behavioral_response1.86046102
55MP0004145_abnormal_muscle_electrophysio1.85955483
56MP0006082_CNS_inflammation1.83214907
57MP0004085_abnormal_heartbeat1.82572861
58MP0002405_respiratory_system_inflammati1.82181671
59MP0002653_abnormal_ependyma_morphology1.78640738
60MP0000689_abnormal_spleen_morphology1.77850770
61MP0005620_abnormal_muscle_contractility1.77260060
62MP0000749_muscle_degeneration1.76282977
63MP0002722_abnormal_immune_system1.75994554
64MP0000716_abnormal_immune_system1.75890754
65MP0004087_abnormal_muscle_fiber1.73582297
66MP0002148_abnormal_hypersensitivity_rea1.71514953
67MP0006138_congestive_heart_failure1.67904278
68MP0003191_abnormal_cellular_cholesterol1.65878466
69MP0008775_abnormal_heart_ventricle1.65598904
70MP0002429_abnormal_blood_cell1.64365425
71MP0001544_abnormal_cardiovascular_syste1.64125684
72MP0005385_cardiovascular_system_phenoty1.64125684
73MP0002909_abnormal_adrenal_gland1.63434379
74MP0002106_abnormal_muscle_physiology1.57166394
75MP0005646_abnormal_pituitary_gland1.56342891
76MP0001845_abnormal_inflammatory_respons1.54675866
77MP0003866_abnormal_defecation1.54461758
78MP0002734_abnormal_mechanical_nocicepti1.51113687
79MP0010155_abnormal_intestine_physiology1.49509082
80MP0004924_abnormal_behavior1.49404743
81MP0005386_behavior/neurological_phenoty1.49404743
82MP0002272_abnormal_nervous_system1.49265797
83MP0003718_maternal_effect1.47894448
84MP0000703_abnormal_thymus_morphology1.43978101
85MP0008877_abnormal_DNA_methylation1.43319333
86MP0002735_abnormal_chemical_nociception1.43299342
87MP0008469_abnormal_protein_level1.42828280
88MP0002572_abnormal_emotion/affect_behav1.42505612
89MP0002064_seizures1.40545893
90MP0001533_abnormal_skeleton_physiology1.39140260
91MP0001968_abnormal_touch/_nociception1.38067763
92MP0003787_abnormal_imprinting1.36892476
93MP0002269_muscular_atrophy1.36759856
94MP0004947_skin_inflammation1.35460533
95MP0009840_abnormal_foam_cell1.35144371
96MP0003183_abnormal_peptide_metabolism1.34202455
97MP0009046_muscle_twitch1.33197120
98MP0002736_abnormal_nociception_after1.32801348
99MP0001970_abnormal_pain_threshold1.31860525
100MP0001984_abnormal_olfaction1.31732072
101MP0000465_gastrointestinal_hemorrhage1.30996641
102MP0001501_abnormal_sleep_pattern1.27402383
103MP0010234_abnormal_vibrissa_follicle1.23971209
104MP0008569_lethality_at_weaning1.20688383
105MP0003221_abnormal_cardiomyocyte_apopto1.19478809
106MP0004233_abnormal_muscle_weight1.19459693
107MP0003329_amyloid_beta_deposits1.19455341
108MP0001486_abnormal_startle_reflex1.18366441
109MP0000750_abnormal_muscle_regeneration1.17922978
110MP0009764_decreased_sensitivity_to1.17384363
111MP0010630_abnormal_cardiac_muscle1.16030193
112MP0004185_abnormal_adipocyte_glucose1.14798302
113MP0002733_abnormal_thermal_nociception1.14608365
114MP0001905_abnormal_dopamine_level1.13769580
115MP0005369_muscle_phenotype1.13407466
116MP0002166_altered_tumor_susceptibility1.12094792
117MP0005310_abnormal_salivary_gland1.10990728
118MP0003879_abnormal_hair_cell1.10453110
119MP0004808_abnormal_hematopoietic_stem1.10318049
120MP0002127_abnormal_cardiovascular_syste1.08914979
121MP0002184_abnormal_innervation1.08397528
122MP0000858_altered_metastatic_potential1.08129587
123MP0002332_abnormal_exercise_endurance1.07082643
124MP0003806_abnormal_nucleotide_metabolis1.05096580
125MP0001873_stomach_inflammation1.01479127
126MP0006276_abnormal_autonomic_nervous1.00942071
127MP0001440_abnormal_grooming_behavior1.00502095
128MP0001502_abnormal_circadian_rhythm0.99599269
129MP0005075_abnormal_melanosome_morpholog0.99163778
130MP0000759_abnormal_skeletal_muscle0.99011518
131MP0000490_abnormal_crypts_of0.97686384
132MP0002067_abnormal_sensory_capabilities0.96662337
133MP0003075_altered_response_to0.95695654
134MP0004130_abnormal_muscle_cell0.94856165
135MP0006036_abnormal_mitochondrial_physio0.94556000
136MP0003123_paternal_imprinting0.94527534
137MP0004858_abnormal_nervous_system0.90318801
138MP0009763_increased_sensitivity_to0.89192042
139MP0000604_amyloidosis0.87911652
140MP0000609_abnormal_liver_physiology0.87544307
141MP0001663_abnormal_digestive_system0.86523400
142MP0001986_abnormal_taste_sensitivity0.85455013
143MP0010386_abnormal_urinary_bladder0.84029772
144MP0005319_abnormal_enzyme/_coenzyme0.82901421
145MP0005167_abnormal_blood-brain_barrier0.82100550
146MP0001851_eye_inflammation0.80619094
147MP0002138_abnormal_hepatobiliary_system0.80004212
148MP0008874_decreased_physiological_sensi0.79728647
149MP0000343_altered_response_to0.79447382
150MP0004381_abnormal_hair_follicle0.79322195
151MP0005636_abnormal_mineral_homeostasis0.79320258
152MP0004811_abnormal_neuron_physiology0.77772052
153MP0002139_abnormal_hepatobiliary_system0.76753361
154MP0005076_abnormal_cell_differentiation0.76732899
155MP0006292_abnormal_olfactory_placode0.76710994
156MP0003699_abnormal_female_reproductive0.74527069
157MP0002066_abnormal_motor_capabilities/c0.74232297
158MP0006035_abnormal_mitochondrial_morpho0.74142475
159MP0002638_abnormal_pupillary_reflex0.73370200
160MP0002019_abnormal_tumor_incidence0.72975735
161MP0000747_muscle_weakness0.72440491
162MP0003828_pulmonary_edema0.71905619
163MP0001853_heart_inflammation0.71520030
164MP0001765_abnormal_ion_homeostasis0.71515469
165MP0002557_abnormal_social/conspecific_i0.69978646
166MP0009765_abnormal_xenobiotic_induced0.69051402
167MP0008961_abnormal_basal_metabolism0.68130006
168MP0000230_abnormal_systemic_arterial0.67815665
169MP0005165_increased_susceptibility_to0.67589245
170MP0008004_abnormal_stomach_pH0.67279510
171MP0005187_abnormal_penis_morphology0.67200943
172MP0005377_hearing/vestibular/ear_phenot0.67034569
173MP0003878_abnormal_ear_physiology0.67034569
174MP0000955_abnormal_spinal_cord0.65705353
175MP0005164_abnormal_response_to0.65634066
176MP0000639_abnormal_adrenal_gland0.64971445
177MP0002882_abnormal_neuron_morphology0.64272262
178MP0000598_abnormal_liver_morphology0.63610872
179MP0002998_abnormal_bone_remodeling0.63090704
180MP0001119_abnormal_female_reproductive0.62448464
181MP0005166_decreased_susceptibility_to0.62047058
182MP0002693_abnormal_pancreas_physiology0.61700221
183MP0000313_abnormal_cell_death0.59983957
184MP0005535_abnormal_body_temperature0.59115088
185MP0003690_abnormal_glial_cell0.58564695
186MP0005423_abnormal_somatic_nervous0.58426130
187MP0009642_abnormal_blood_homeostasis0.57941016
188MP0004883_abnormal_blood_vessel0.57884827
189MP0000579_abnormal_nail_morphology0.56619951

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)7.44098528
2Hypochromic microcytic anemia (HP:0004840)6.72661135
3Sudden death (HP:0001699)6.14342056
4Bundle branch block (HP:0011710)5.85706094
5Myokymia (HP:0002411)5.71940690
6Atrial fibrillation (HP:0005110)5.33120672
7Ventricular fibrillation (HP:0001663)5.12028957
8Hypochromic anemia (HP:0001931)5.08905258
9Primary atrial arrhythmia (HP:0001692)5.08475588
10Ventricular tachycardia (HP:0004756)5.03447308
11Eczematoid dermatitis (HP:0000976)5.02429272
12Syncope (HP:0001279)4.98054140
13Supraventricular tachycardia (HP:0004755)4.87090319
14Supraventricular arrhythmia (HP:0005115)4.72040882
15Recurrent abscess formation (HP:0002722)4.67194351
16Heart block (HP:0012722)4.66935838
17Focal motor seizures (HP:0011153)4.54534173
18Recurrent bacterial skin infections (HP:0005406)4.46572592
19Abnormal atrioventricular conduction (HP:0005150)4.33639207
20Microcytic anemia (HP:0001935)4.28280220
21Atrioventricular block (HP:0001678)4.25688102
22Prolonged bleeding time (HP:0003010)4.22817494
23Abnormality of macrophages (HP:0004311)4.22471816
24Poikilocytosis (HP:0004447)4.17285025
25Recurrent gram-negative bacterial infections (HP:0005420)4.04427912
26Myositis (HP:0100614)3.99611841
27Male infertility (HP:0003251)3.94288790
28Prolonged QT interval (HP:0001657)3.93557181
29Gastrointestinal infarctions (HP:0005244)3.92383951
30Obstructive lung disease (HP:0006536)3.91560047
31Chronic obstructive pulmonary disease (HP:0006510)3.91560047
32Stomatitis (HP:0010280)3.88139629
33Calf muscle hypertrophy (HP:0008981)3.83334578
34Ventricular arrhythmia (HP:0004308)3.79638219
35Reticulocytosis (HP:0001923)3.50191078
36Exercise-induced myalgia (HP:0003738)3.49644675
37Orchitis (HP:0100796)3.46959011
38Abnormal hemoglobin (HP:0011902)3.46762095
39Right ventricular cardiomyopathy (HP:0011663)3.44428980
40Elevated erythrocyte sedimentation rate (HP:0003565)3.41807107
41Muscle hypertrophy of the lower extremities (HP:0008968)3.38169638
42Meningitis (HP:0001287)3.35073033
43Lipoatrophy (HP:0100578)3.33746339
44Abnormal EKG (HP:0003115)3.28757209
45Palpitations (HP:0001962)3.28725429
46Abnormality of the calf musculature (HP:0001430)3.28310981
47Petechiae (HP:0000967)3.27649688
48Polycythemia (HP:0001901)3.27231076
49Mediastinal lymphadenopathy (HP:0100721)3.26549992
50Muscle fiber splitting (HP:0003555)3.26166433
51Urticaria (HP:0001025)3.18764222
52Recurrent fungal infections (HP:0002841)3.18220282
53Epistaxis (HP:0000421)3.17524248
54Optic neuritis (HP:0100653)3.17002934
55Retrobulbar optic neuritis (HP:0100654)3.17002934
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.12616060
57Abnormal delayed hypersensitivity skin test (HP:0002963)3.12471388
58Febrile seizures (HP:0002373)3.10639501
59Recurrent skin infections (HP:0001581)3.03936330
60Left ventricular hypertrophy (HP:0001712)3.03071837
61Dysmetric saccades (HP:0000641)3.02608882
62Increased serum ferritin (HP:0003281)2.98616503
63Atonic seizures (HP:0010819)2.96412635
64Cellulitis (HP:0100658)2.96152408
65Subaortic stenosis (HP:0001682)2.95248477
66Abnormality of the left ventricular outflow tract (HP:0011103)2.95248477
67Cholelithiasis (HP:0001081)2.94958711
68Gingival bleeding (HP:0000225)2.93835693
69Acute necrotizing encephalopathy (HP:0006965)2.93458603
70Abnormality of iron homeostasis (HP:0011031)2.92820563
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.86464774
72Abnormality of alanine metabolism (HP:0010916)2.86464774
73Hyperalaninemia (HP:0003348)2.86464774
74Abnormal mitochondria in muscle tissue (HP:0008316)2.86022174
75Focal seizures (HP:0007359)2.85001617
76Vasculitis (HP:0002633)2.82446453
77Encephalitis (HP:0002383)2.81443950
78Exercise-induced muscle cramps (HP:0003710)2.81399690
79Episodic fever (HP:0001954)2.79674347
80Purpura (HP:0000979)2.79246550
81Increased IgE level (HP:0003212)2.76441846
82Dilated cardiomyopathy (HP:0001644)2.75864733
83Gastrointestinal inflammation (HP:0004386)2.73889661
84Asymmetric septal hypertrophy (HP:0001670)2.71939587
85Acanthocytosis (HP:0001927)2.69891333
86Gingivitis (HP:0000230)2.65536970
87Inflammation of the large intestine (HP:0002037)2.64891884
88Osteomyelitis (HP:0002754)2.61764729
89Recurrent viral infections (HP:0004429)2.61423270
90Abnormal gallbladder morphology (HP:0012437)2.58811378
91Hyporeflexia of lower limbs (HP:0002600)2.56150258
92Myotonia (HP:0002486)2.53826156
93Chronic mucocutaneous candidiasis (HP:0002728)2.53710822
94Recurrent cutaneous fungal infections (HP:0011370)2.53710822
95Abnormality of transition element cation homeostasis (HP:0011030)2.51720417
96Spontaneous hematomas (HP:0007420)2.49515986
97Toxemia of pregnancy (HP:0100603)2.49363659
98Abnormal gallbladder physiology (HP:0012438)2.46626021
99Cholecystitis (HP:0001082)2.46626021
100Pustule (HP:0200039)2.46312256
101Acute encephalopathy (HP:0006846)2.45633710
102Progressive macrocephaly (HP:0004481)2.45427420
103Granulocytopenia (HP:0001913)2.40871830
104Chest pain (HP:0100749)2.38339829
105Keratoconjunctivitis sicca (HP:0001097)2.36787282
106Papillary thyroid carcinoma (HP:0002895)2.33096687
107Paralysis (HP:0003470)2.32342662
108Testicular atrophy (HP:0000029)2.30394328
109Visual hallucinations (HP:0002367)2.29491288
110Agammaglobulinemia (HP:0004432)2.28605626
111Areflexia of lower limbs (HP:0002522)2.26185264
112Panhypogammaglobulinemia (HP:0003139)2.24969950
113Pheochromocytoma (HP:0002666)2.23921312
114Anorexia (HP:0002039)2.23371874
115Abnormality of reticulocytes (HP:0004312)2.22678859
116Palmoplantar keratoderma (HP:0000982)2.21564062
117Myoglobinuria (HP:0002913)2.20829827
118Hypertensive crisis (HP:0100735)2.20578824
119Abnormality of T cell physiology (HP:0011840)2.20319196
120Annular pancreas (HP:0001734)2.15368814
121Hepatocellular necrosis (HP:0001404)2.15165525
122Colitis (HP:0002583)2.14983448
123Keratoconjunctivitis (HP:0001096)2.14028661
124Increased IgM level (HP:0003496)2.12799179
125Mitochondrial inheritance (HP:0001427)2.10954553
126Hepatic necrosis (HP:0002605)2.09910147
127Abnormality of the gallbladder (HP:0005264)2.09881880
128Amyloidosis (HP:0011034)2.09550696
129EMG: myopathic abnormalities (HP:0003458)2.08483793
130Pulmonary infiltrates (HP:0002113)2.08114142
131Ulnar claw (HP:0001178)2.07789425
132Hepatosplenomegaly (HP:0001433)2.07421839
133Leukocytosis (HP:0001974)2.05897354
134Slow saccadic eye movements (HP:0000514)2.05663284
135Arterial thrombosis (HP:0004420)2.05205868
136Diaphragmatic weakness (HP:0009113)2.04263285
137Action tremor (HP:0002345)2.03558878
138Anosmia (HP:0000458)2.02600545
139Skin rash (HP:0000988)2.01803315
140Acute hepatic failure (HP:0006554)2.01638912
141Fetal akinesia sequence (HP:0001989)2.01567895
142Thrombophlebitis (HP:0004418)2.00579325
143Torticollis (HP:0000473)2.00489953
144Anxiety (HP:0000739)2.00425990
145Autoimmune thrombocytopenia (HP:0001973)1.99812622
146Pulmonary embolism (HP:0002204)1.99732800
147Unsteady gait (HP:0002317)1.99722895
148Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98169730
149Hyperbilirubinemia (HP:0002904)1.97932859
150Abnormality of T cells (HP:0002843)1.96722914
151Abnormal platelet function (HP:0011869)1.96446262
152Impaired platelet aggregation (HP:0003540)1.96446262
153Generalized tonic-clonic seizures (HP:0002069)1.94721563
154Thrombocytosis (HP:0001894)1.94420817
155Hemoptysis (HP:0002105)1.94048013
156Pallor (HP:0000980)1.92262252
157Neuroendocrine neoplasm (HP:0100634)1.92100603
158Abnormal platelet volume (HP:0011876)1.91248304
159IgM deficiency (HP:0002850)1.91178551
160Increased intramyocellular lipid droplets (HP:0012240)1.90475784
161Splenomegaly (HP:0001744)1.89632044
162Joint hemorrhage (HP:0005261)1.88721718
163Cutaneous photosensitivity (HP:0000992)1.88721569
164Progressive inability to walk (HP:0002505)1.88272335
165Increased muscle lipid content (HP:0009058)1.87395001
166Severe visual impairment (HP:0001141)1.86312467
167Autoimmune hemolytic anemia (HP:0001890)1.85754769
168Urinary bladder sphincter dysfunction (HP:0002839)1.85346502
169Joint swelling (HP:0001386)1.85250514
170Increased CSF lactate (HP:0002490)1.85243044
171Lymphopenia (HP:0001888)1.85100336
172Gaze-evoked nystagmus (HP:0000640)1.84885275
173Dysmetria (HP:0001310)1.82918637
174Absence seizures (HP:0002121)1.82774019
175Difficulty climbing stairs (HP:0003551)1.82674957
176Impaired vibration sensation in the lower limbs (HP:0002166)1.82627772
177Foot dorsiflexor weakness (HP:0009027)1.80678895
178Progressive cerebellar ataxia (HP:0002073)1.77310611
179Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76555108
180Difficulty running (HP:0009046)1.75212913
181Bradycardia (HP:0001662)1.75060939
182Amblyopia (HP:0000646)1.74679680
183Epileptic encephalopathy (HP:0200134)1.73918222
184Abnormality of the foot musculature (HP:0001436)1.72716176
185Shawl scrotum (HP:0000049)1.72055349
186Rapidly progressive (HP:0003678)1.71371738
187Dysdiadochokinesis (HP:0002075)1.70661692
188Lactic acidosis (HP:0003128)1.68861201
189Cystic hygroma (HP:0000476)1.68704770
190Poor eye contact (HP:0000817)1.67989153
191Congenital malformation of the right heart (HP:0011723)1.65882761
192Double outlet right ventricle (HP:0001719)1.65882761
193Abnormality of the vocal cords (HP:0008777)1.64958700
194Depression (HP:0000716)1.64467582
195Distal lower limb amyotrophy (HP:0008944)1.63542482
196Ketoacidosis (HP:0001993)1.60267199
197EMG: neuropathic changes (HP:0003445)1.60257953
198Focal dystonia (HP:0004373)1.59574622
199Athetosis (HP:0002305)1.58115950
200Gowers sign (HP:0003391)1.57998438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR24.21809020
2MAP3K93.97467826
3MUSK3.60542994
4EPHA43.50611309
5MAP4K13.49933190
6MAP2K33.32505729
7ERN13.06877509
8ARAF3.00704832
9LATS22.96963266
10MAP3K112.85287400
11TAOK12.74982984
12GRK62.66854836
13MAP3K132.66759538
14IRAK42.54929408
15STK38L2.51398240
16MAP3K62.37633856
17RAF12.35074898
18TNK22.32924025
19FES2.25320648
20BLK2.18056448
21PAK62.17487077
22NTRK32.17249504
23LMTK22.16842266
24PRKD32.10175482
25TAOK22.09049053
26MAPKAPK32.03668860
27BRAF2.01849355
28TYK21.95635754
29MAP3K31.93490213
30PINK11.92197967
31KSR11.87604850
32MAP3K41.87211203
33STK381.85381860
34BMPR21.74722637
35SYK1.74044102
36DMPK1.73778195
37LATS11.71870786
38MAP3K121.68130068
39BTK1.63837916
40CSK1.63090687
41ZAP701.62535808
42ERBB41.59646389
43EIF2AK11.59544862
44MOS1.55839147
45MAP2K71.55235098
46FGR1.54710425
47TBK11.42288507
48HCK1.37634895
49SMG11.32203517
50STK241.29265723
51PHKG21.29209098
52PHKG11.29209098
53IRAK31.29010302
54PLK41.27480351
55TXK1.26307435
56LYN1.23327718
57ICK1.22638536
58MAP3K141.22125061
59TTN1.20873620
60MAP2K41.20627370
61MINK11.20227614
62EEF2K1.18024203
63JAK31.13963963
64IKBKE1.13541311
65MYLK1.12939760
66PDK31.12314061
67PDK41.12314061
68CDK121.12061958
69TESK21.06515658
70NEK11.06308407
71CAMK2A1.05108870
72PAK31.02814487
73SIK21.00215415
74MARK30.99457120
75RIPK40.97105940
76CSF1R0.94729644
77ITK0.94055309
78MATK0.93477555
79JAK20.93383113
80BCKDK0.93367674
81IKBKB0.92735827
82MAP3K10.91167047
83PIM10.90172791
84SIK10.89618656
85PRKD20.87577205
86DAPK20.87531088
87NTRK20.86862153
88MAPK130.86775490
89KIT0.86728388
90TYRO30.83905293
91LCK0.83440998
92RET0.81780029
93MARK20.79069091
94PRKCQ0.78287927
95SGK20.78198660
96FGFR40.78032749
97NME20.77861844
98MAP3K50.77186832
99MAPK120.77171670
100BMX0.76503964
101TEC0.76147101
102MAP2K20.75853653
103TRIB30.75149070
104HIPK20.74716873
105GRK50.72315250
106TTK0.70031661
107GRK70.68449261
108MAP3K70.64767918
109PDPK10.63586107
110NTRK10.63505732
111SGK2230.62555987
112SGK4940.62555987
113LRRK20.62304105
114DYRK1B0.62285979
115MAP3K80.61134472
116RPS6KC10.60895995
117RPS6KL10.60895995
118CDK190.59435699
119PRKAA10.59423634
120EPHB10.58701949
121MAP2K10.58615889
122PDK10.58571688
123IRAK20.57899164
124SIK30.57846162
125CAMKK10.57538337
126CDK50.57213009
127MAP3K20.56447370
128MAPK110.56325590
129PTK60.55246739
130SGK30.55098781
131CAMK2D0.53110629
132MAP3K100.51425101
133PRKCH0.51008653
134PTK2B0.50550006
135WNK40.50455667
136RPS6KA60.49284939
137CDK40.47251175
138JAK10.45559741
139FGFR30.45293467
140STK110.44763320
141CAMK10.44651915
142PRKD10.43725694
143PRKAA20.43614800
144FYN0.43005715
145CAMK2G0.42120460
146IRAK10.41941432
147TAOK30.41549344
148YES10.41055246
149ROCK10.40674514
150PIM20.40464838
151ABL20.40355185
152CAMK1D0.38951161
153PLK20.38728430
154PDK20.38649380
155STK40.38305304
156CDK90.38291860
157TRPM70.37310788
158DAPK10.36971058
159CDC42BPA0.34822483
160CDK80.34148021
161MELK0.30675310
162SGK10.28333931
163MAPKAPK50.27310020
164PRPF4B0.27295463
165CDK180.26778563
166BRSK10.26338064
167CDK150.26014879
168PRKACA0.25551932
169DYRK20.25241854
170WNK10.22637117
171CAMK40.21816889
172PRKCG0.21699057
173CDK11A0.19593805
174PKN20.19429195

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.76531964
2Leishmaniasis_Homo sapiens_hsa051402.76290915
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.75501060
4Olfactory transduction_Homo sapiens_hsa047402.72333180
5Cardiac muscle contraction_Homo sapiens_hsa042602.65233544
6Staphylococcus aureus infection_Homo sapiens_hsa051502.58750804
7Malaria_Homo sapiens_hsa051442.56681179
8B cell receptor signaling pathway_Homo sapiens_hsa046622.56397173
9Primary immunodeficiency_Homo sapiens_hsa053402.42730244
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30918102
11Acute myeloid leukemia_Homo sapiens_hsa052212.16986418
12Long-term potentiation_Homo sapiens_hsa047202.15253328
13Dilated cardiomyopathy_Homo sapiens_hsa054142.12827476
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11168292
15Synaptic vesicle cycle_Homo sapiens_hsa047212.05298047
16Graft-versus-host disease_Homo sapiens_hsa053322.03912441
17Other glycan degradation_Homo sapiens_hsa005111.99138610
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97487925
19Allograft rejection_Homo sapiens_hsa053301.96148997
20Oxidative phosphorylation_Homo sapiens_hsa001901.95174281
21GnRH signaling pathway_Homo sapiens_hsa049121.93590447
22Parkinsons disease_Homo sapiens_hsa050121.92752588
23Circadian entrainment_Homo sapiens_hsa047131.90189472
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88258545
25Amphetamine addiction_Homo sapiens_hsa050311.86386577
26Tuberculosis_Homo sapiens_hsa051521.85504784
27Ovarian steroidogenesis_Homo sapiens_hsa049131.84765489
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.82775103
29Autoimmune thyroid disease_Homo sapiens_hsa053201.81672066
30Hematopoietic cell lineage_Homo sapiens_hsa046401.80879515
31Glutamatergic synapse_Homo sapiens_hsa047241.79914520
32Nicotine addiction_Homo sapiens_hsa050331.79866479
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.75029431
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73466150
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.69936226
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69537952
37Morphine addiction_Homo sapiens_hsa050321.64153343
38Oxytocin signaling pathway_Homo sapiens_hsa049211.63568407
39Cholinergic synapse_Homo sapiens_hsa047251.62566810
40Dopaminergic synapse_Homo sapiens_hsa047281.61126427
41African trypanosomiasis_Homo sapiens_hsa051431.59904649
42Circadian rhythm_Homo sapiens_hsa047101.59133734
43T cell receptor signaling pathway_Homo sapiens_hsa046601.58725233
44Gastric acid secretion_Homo sapiens_hsa049711.56811834
45Alzheimers disease_Homo sapiens_hsa050101.56744532
46Huntingtons disease_Homo sapiens_hsa050161.55078394
47Herpes simplex infection_Homo sapiens_hsa051681.52674556
48Salivary secretion_Homo sapiens_hsa049701.52159094
49Measles_Homo sapiens_hsa051621.51690759
50Oocyte meiosis_Homo sapiens_hsa041141.47215629
51Calcium signaling pathway_Homo sapiens_hsa040201.46936948
52Insulin secretion_Homo sapiens_hsa049111.43851762
53Type I diabetes mellitus_Homo sapiens_hsa049401.43480145
54cAMP signaling pathway_Homo sapiens_hsa040241.41716176
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40449090
56Antigen processing and presentation_Homo sapiens_hsa046121.39367245
57Chronic myeloid leukemia_Homo sapiens_hsa052201.38963372
58Influenza A_Homo sapiens_hsa051641.36597024
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36076934
60Asthma_Homo sapiens_hsa053101.35480267
61VEGF signaling pathway_Homo sapiens_hsa043701.32112171
62Serotonergic synapse_Homo sapiens_hsa047261.31732395
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31715065
64Adipocytokine signaling pathway_Homo sapiens_hsa049201.28525677
65Taste transduction_Homo sapiens_hsa047421.27772801
66GABAergic synapse_Homo sapiens_hsa047271.27468109
67Toxoplasmosis_Homo sapiens_hsa051451.27437281
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27342548
69Cocaine addiction_Homo sapiens_hsa050301.25842691
70Long-term depression_Homo sapiens_hsa047301.25336152
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23926481
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23683880
73Dorso-ventral axis formation_Homo sapiens_hsa043201.23304069
74Renin secretion_Homo sapiens_hsa049241.22809900
75Vascular smooth muscle contraction_Homo sapiens_hsa042701.22185704
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22074364
77Jak-STAT signaling pathway_Homo sapiens_hsa046301.21361467
78Intestinal immune network for IgA production_Homo sapiens_hsa046721.16982132
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16268210
80Glycosaminoglycan degradation_Homo sapiens_hsa005311.12041305
81Hepatitis B_Homo sapiens_hsa051611.11369633
82Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09326089
83Hepatitis C_Homo sapiens_hsa051601.08799185
84Choline metabolism in cancer_Homo sapiens_hsa052311.08413164
85Platelet activation_Homo sapiens_hsa046111.06862263
86TNF signaling pathway_Homo sapiens_hsa046681.06371723
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06182506
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04244217
89Gap junction_Homo sapiens_hsa045401.03929909
90Apoptosis_Homo sapiens_hsa042101.03718928
91SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03361209
92Legionellosis_Homo sapiens_hsa051341.02443158
93Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02047267
94Estrogen signaling pathway_Homo sapiens_hsa049151.01925489
95Phagosome_Homo sapiens_hsa041451.00339077
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99992751
97Collecting duct acid secretion_Homo sapiens_hsa049660.99859147
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98669338
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97175114
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92592260
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.91876716
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89961635
103Viral myocarditis_Homo sapiens_hsa054160.89600511
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.87710717
105Glioma_Homo sapiens_hsa052140.86328384
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85172114
107Prolactin signaling pathway_Homo sapiens_hsa049170.84604543
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81847921
109Lysosome_Homo sapiens_hsa041420.81449007
110Glucagon signaling pathway_Homo sapiens_hsa049220.78845306
111Viral carcinogenesis_Homo sapiens_hsa052030.78730375
112Epstein-Barr virus infection_Homo sapiens_hsa051690.78349652
113Shigellosis_Homo sapiens_hsa051310.77149805
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77033384
115ErbB signaling pathway_Homo sapiens_hsa040120.76521264
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76324381
117Pancreatic cancer_Homo sapiens_hsa052120.74683560
118Notch signaling pathway_Homo sapiens_hsa043300.74493693
119Type II diabetes mellitus_Homo sapiens_hsa049300.74131379
120Melanogenesis_Homo sapiens_hsa049160.73187024
121Complement and coagulation cascades_Homo sapiens_hsa046100.72525260
122Ras signaling pathway_Homo sapiens_hsa040140.71353917
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71285280
124MAPK signaling pathway_Homo sapiens_hsa040100.71258550
125Regulation of autophagy_Homo sapiens_hsa041400.70528254
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69668962
127Renal cell carcinoma_Homo sapiens_hsa052110.69083432
128Inositol phosphate metabolism_Homo sapiens_hsa005620.68945957
129Pertussis_Homo sapiens_hsa051330.67137407
130Rheumatoid arthritis_Homo sapiens_hsa053230.66081236
131Salmonella infection_Homo sapiens_hsa051320.65755897
132Vitamin B6 metabolism_Homo sapiens_hsa007500.65561289
133mTOR signaling pathway_Homo sapiens_hsa041500.65190017
134Insulin signaling pathway_Homo sapiens_hsa049100.65050176
135RNA degradation_Homo sapiens_hsa030180.64848343
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64512251
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64408263
138Propanoate metabolism_Homo sapiens_hsa006400.62702678
139Endometrial cancer_Homo sapiens_hsa052130.61399573
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.61133487
141Pancreatic secretion_Homo sapiens_hsa049720.60697560
142Base excision repair_Homo sapiens_hsa034100.59807433
143Systemic lupus erythematosus_Homo sapiens_hsa053220.59717817
144Non-small cell lung cancer_Homo sapiens_hsa052230.59679766
145Endocytosis_Homo sapiens_hsa041440.59652903
146Pentose phosphate pathway_Homo sapiens_hsa000300.58522455
147Insulin resistance_Homo sapiens_hsa049310.58385954
148Fructose and mannose metabolism_Homo sapiens_hsa000510.57812530
149Rap1 signaling pathway_Homo sapiens_hsa040150.57565358
150Linoleic acid metabolism_Homo sapiens_hsa005910.54851326
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54690601
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53371120
153HTLV-I infection_Homo sapiens_hsa051660.53221679
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.51788950
155Bladder cancer_Homo sapiens_hsa052190.50922009
156Thyroid cancer_Homo sapiens_hsa052160.49682712
157Ether lipid metabolism_Homo sapiens_hsa005650.47368876
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46890259
159Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46132109
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45891741
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45545648
162FoxO signaling pathway_Homo sapiens_hsa040680.43485860
163Pyruvate metabolism_Homo sapiens_hsa006200.41985308
164Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41740482
165Colorectal cancer_Homo sapiens_hsa052100.41233009
166Neurotrophin signaling pathway_Homo sapiens_hsa047220.40953590
167Prion diseases_Homo sapiens_hsa050200.39285129
168HIF-1 signaling pathway_Homo sapiens_hsa040660.39242593
169Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36522990
170Thyroid hormone synthesis_Homo sapiens_hsa049180.35685798
171Carbon metabolism_Homo sapiens_hsa012000.34577479
172Chemokine signaling pathway_Homo sapiens_hsa040620.34301257
173Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33388584
174Sulfur relay system_Homo sapiens_hsa041220.33343520

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