TESK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.48542647
2cilium or flagellum-dependent cell motility (GO:0001539)9.47744611
3cell-cell recognition (GO:0009988)9.33870051
4multicellular organism reproduction (GO:0032504)9.28232152
5plasma membrane fusion (GO:0045026)9.15041417
6spermatid development (GO:0007286)8.96612838
7axonemal dynein complex assembly (GO:0070286)8.94251460
8motile cilium assembly (GO:0044458)8.57362864
9epithelial cilium movement (GO:0003351)8.55140359
10reproduction (GO:0000003)8.02135289
11regulation of cilium movement (GO:0003352)7.91696442
12piRNA metabolic process (GO:0034587)7.56224908
13synaptonemal complex organization (GO:0070193)7.23437975
14cilium movement (GO:0003341)7.09570863
15synaptonemal complex assembly (GO:0007130)7.01210846
16negative regulation of inclusion body assembly (GO:0090084)6.93122765
17male meiosis (GO:0007140)6.84541206
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.63124374
19sperm capacitation (GO:0048240)6.60875307
20single fertilization (GO:0007338)6.33308274
21organic cation transport (GO:0015695)6.28598199
22* spermatogenesis (GO:0007283)6.04977031
23* male gamete generation (GO:0048232)6.02337427
24fertilization (GO:0009566)5.65897250
25regulation of inclusion body assembly (GO:0090083)5.63011108
26calcium ion-dependent exocytosis (GO:0017156)5.56276779
27* gamete generation (GO:0007276)5.51137548
28cellular process involved in reproduction in multicellular organism (GO:0022412)5.15388636
29germ cell development (GO:0007281)5.08529169
30regulation of microtubule-based movement (GO:0060632)5.04348332
31ventricular system development (GO:0021591)4.98415808
32seminiferous tubule development (GO:0072520)4.91531071
33male meiosis I (GO:0007141)4.78582733
34left/right pattern formation (GO:0060972)4.71919089
35microtubule severing (GO:0051013)4.71377350
36cell recognition (GO:0008037)4.69790079
37microtubule depolymerization (GO:0007019)4.61437459
38DNA methylation involved in gamete generation (GO:0043046)4.51183311
39chromosome organization involved in meiosis (GO:0070192)4.36928663
40* multicellular organismal reproductive process (GO:0048609)4.36623567
41chromosome condensation (GO:0030261)4.23064129
42DNA packaging (GO:0006323)4.08455103
43negative regulation of erythrocyte differentiation (GO:0045647)4.00956502
44meiotic nuclear division (GO:0007126)3.94680232
45carnitine transport (GO:0015879)3.84796999
46amino-acid betaine transport (GO:0015838)3.84796999
47carnitine transmembrane transport (GO:1902603)3.74025556
48meiosis I (GO:0007127)3.73963139
49glycerol ether metabolic process (GO:0006662)3.65214824
50sexual reproduction (GO:0019953)3.60796267
51multicellular organismal development (GO:0007275)3.60738684
52genitalia morphogenesis (GO:0035112)3.52743896
53negative regulation of organelle assembly (GO:1902116)3.51684769
54low-density lipoprotein particle clearance (GO:0034383)3.50730625
55barbed-end actin filament capping (GO:0051016)3.45428568
56protein localization to cilium (GO:0061512)3.43984718
57protein polyglutamylation (GO:0018095)3.41525265
58spermatid nucleus differentiation (GO:0007289)3.39587778
59chaperone-mediated protein complex assembly (GO:0051131)3.38091868
60stress fiber assembly (GO:0043149)3.37810129
61ether metabolic process (GO:0018904)3.35257942
62protein localization to endosome (GO:0036010)3.26250861
63regulation of T-helper 2 cell differentiation (GO:0045628)3.24794770
64regulation of early endosome to late endosome transport (GO:2000641)3.16035442
65sequestering of actin monomers (GO:0042989)3.15230962
66RNA localization (GO:0006403)3.13789468
67meiotic cell cycle (GO:0051321)3.13095319
68glycolytic process (GO:0006096)3.07248855
69monoubiquitinated protein deubiquitination (GO:0035520)3.01211115
70protein refolding (GO:0042026)2.99562707
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97675945
72regulation of cilium assembly (GO:1902017)2.95226150
73mannose metabolic process (GO:0006013)2.91088968
74germinal center formation (GO:0002467)2.90534299
75gene silencing by RNA (GO:0031047)2.88752114
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.88427588
77response to acidic pH (GO:0010447)2.88004306
78regulation of ARF GTPase activity (GO:0032312)2.87297348
79microtubule-based movement (GO:0007018)2.86290971
80RNA destabilization (GO:0050779)2.82217047
81endothelial cell chemotaxis (GO:0035767)2.80913289
82interferon-gamma secretion (GO:0072643)2.80593323
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78126123
84negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.75795980
85polyol catabolic process (GO:0046174)2.71920522
86quaternary ammonium group transport (GO:0015697)2.69987314
87negative regulation of granulocyte differentiation (GO:0030853)2.69106582
88peptidyl-glutamic acid modification (GO:0018200)2.65722541
89cell-cell junction maintenance (GO:0045217)2.64019387
90positive regulation of receptor recycling (GO:0001921)2.63906397
91positive regulation of myotube differentiation (GO:0010831)2.63626496
92regulation of spindle checkpoint (GO:0090231)2.61622703
93membrane depolarization during action potential (GO:0086010)2.60372791
94positive regulation of macrophage activation (GO:0043032)2.58069672
95CDP-diacylglycerol biosynthetic process (GO:0016024)2.57375245
96cellular response to thyroid hormone stimulus (GO:0097067)2.54978121
97positive regulation of Cdc42 GTPase activity (GO:0043089)2.54207060
98protein-DNA complex disassembly (GO:0032986)2.53475470
99nucleosome disassembly (GO:0006337)2.53475470
100protein K11-linked deubiquitination (GO:0035871)2.52069202
101lactate metabolic process (GO:0006089)2.50720770
102NIK/NF-kappaB signaling (GO:0038061)2.50687653
103gene silencing (GO:0016458)2.50275528
104phospholipid translocation (GO:0045332)2.50270755
105lipid translocation (GO:0034204)2.50270755
106alditol metabolic process (GO:0019400)2.48910416
107mitotic sister chromatid cohesion (GO:0007064)2.48551381
108nucleus organization (GO:0006997)2.48051706
109macrophage activation involved in immune response (GO:0002281)2.47776873
110regulation of ARF protein signal transduction (GO:0032012)2.47202610
111positive regulation of extracellular matrix organization (GO:1903055)2.45996599
112negative regulation of cell size (GO:0045792)2.45396762
113regulation of cholesterol storage (GO:0010885)2.45010436
114calcium ion import (GO:0070509)2.44581366
115regulation of extracellular matrix disassembly (GO:0010715)2.44187351
116regulation of protein kinase C signaling (GO:0090036)2.44080980
117negative regulation of skeletal muscle tissue development (GO:0048642)2.43615712
118response to laminar fluid shear stress (GO:0034616)2.43570530
119positive regulation of protein dephosphorylation (GO:0035307)2.43148100
120adherens junction assembly (GO:0034333)2.42827061
121cellular response to arsenic-containing substance (GO:0071243)2.42684184
122positive regulation of histone deacetylation (GO:0031065)2.42494635
123apoptotic cell clearance (GO:0043277)2.42416745
124axoneme assembly (GO:0035082)2.40112930
125meiotic cell cycle process (GO:1903046)2.39838745
126regulation of membrane protein ectodomain proteolysis (GO:0051043)2.39838193
127semaphorin-plexin signaling pathway (GO:0071526)2.37518870
128positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.36322462
129activation of MAPKKK activity (GO:0000185)2.36071375
130regulation of NFAT protein import into nucleus (GO:0051532)2.35508098
131adhesion of symbiont to host (GO:0044406)2.33869327
132cellular response to pH (GO:0071467)2.33181972
133adhesion of symbiont to host cell (GO:0044650)2.32537046
134virion attachment to host cell (GO:0019062)2.32537046
135hyaluronan catabolic process (GO:0030214)2.30454128
136modulation by symbiont of host cellular process (GO:0044068)2.29548354
137lipopolysaccharide-mediated signaling pathway (GO:0031663)2.29133707
138focal adhesion assembly (GO:0048041)2.28441193
139cell-substrate adherens junction assembly (GO:0007045)2.28441193
140adenosine receptor signaling pathway (GO:0001973)2.27404263
141positive regulation of type 2 immune response (GO:0002830)2.26661371
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.24163840
143cell volume homeostasis (GO:0006884)2.23456504
144skin morphogenesis (GO:0043589)2.21650483
145regulation of cholesterol homeostasis (GO:2000188)2.18690950
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.18223052
147negative regulation of cell killing (GO:0031342)2.18223052
148cell-substrate junction assembly (GO:0007044)2.16912723
149response to peptidoglycan (GO:0032494)2.16246915
150basement membrane organization (GO:0071711)2.16108668
151signal complex assembly (GO:0007172)2.15412586
152sodium ion export (GO:0071436)2.14444167
153protein heterotrimerization (GO:0070208)2.14007818
154cortical actin cytoskeleton organization (GO:0030866)2.13404728
155receptor recycling (GO:0001881)2.13328437
156positive regulation of cholesterol efflux (GO:0010875)2.11771144
157apoptotic process involved in morphogenesis (GO:0060561)2.11275417
158regulation of glucose import in response to insulin stimulus (GO:2001273)2.09745964
159response to thyroid hormone (GO:0097066)2.08944838
160actin filament capping (GO:0051693)2.08783549
161protein retention in ER lumen (GO:0006621)2.07495565
162regulation of type 2 immune response (GO:0002828)2.07326303
163epithelial cell-cell adhesion (GO:0090136)2.06814398
164vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.06774602
165cellular response to epinephrine stimulus (GO:0071872)2.06204253
166antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.06017007
167tooth mineralization (GO:0034505)2.04194027
168positive regulation of Rap GTPase activity (GO:0032854)2.04131176
169endocytic recycling (GO:0032456)2.03639865
170activation of JUN kinase activity (GO:0007257)2.02673840
171retinoic acid receptor signaling pathway (GO:0048384)2.02652047
172regulation of histone H3-K27 methylation (GO:0061085)2.02596408
173protein targeting to plasma membrane (GO:0072661)2.02131897
174epithelial cell differentiation involved in prostate gland development (GO:0060742)2.01852523
175negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.01525727
176serine transport (GO:0032329)2.00868305
177retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.00630312
178intracellular estrogen receptor signaling pathway (GO:0030520)2.00333011
179sperm motility (GO:0030317)12.5222639
180fusion of sperm to egg plasma membrane (GO:0007342)11.8521214
181acrosome reaction (GO:0007340)11.3532194
182cell wall macromolecule metabolic process (GO:0044036)10.5887646
183cell wall macromolecule catabolic process (GO:0016998)10.5887646
184sperm-egg recognition (GO:0035036)10.3777626
185acrosome assembly (GO:0001675)10.2186919
186cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.99251975
187regulation of leukocyte degranulation (GO:0043300)1.98558533
188regulation of extracellular matrix organization (GO:1903053)1.98085314
189antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.97743946
190response to fluid shear stress (GO:0034405)1.96939133
191endoplasmic reticulum calcium ion homeostasis (GO:0032469)1.95784572
192negative regulation of fatty acid transport (GO:2000192)1.93526631
193positive regulation of fat cell differentiation (GO:0045600)1.93390768
194planar cell polarity pathway involved in neural tube closure (GO:0090179)1.93204193
195cortical cytoskeleton organization (GO:0030865)1.92614984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.10951814
2EZH2_22144423_ChIP-Seq_EOC_Human5.32864618
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.38863293
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.20943001
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.91269570
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.84976948
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63002877
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.61858803
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53391605
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52066038
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.36414599
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.33365897
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29638949
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25222181
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23041236
16KDM2B_26808549_Chip-Seq_DND41_Human2.16389219
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.13006686
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09921498
19VDR_21846776_ChIP-Seq_THP-1_Human2.07423263
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.05546670
21RACK7_27058665_Chip-Seq_MCF-7_Human2.02631620
22* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01004499
23GATA1_26923725_Chip-Seq_HPCs_Mouse2.00314890
24KDM2B_26808549_Chip-Seq_K562_Human2.00040709
25ZNF274_21170338_ChIP-Seq_K562_Hela1.99959042
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94392853
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88946892
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84482364
29FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76490699
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76138667
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.71014361
32REST_21632747_ChIP-Seq_MESCs_Mouse1.68067532
33* MYC_22102868_ChIP-Seq_BL_Human1.66627699
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60133969
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59884269
36* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57700432
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55788070
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54248755
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.53367601
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.53162465
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50852492
42* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50698981
43VDR_24763502_ChIP-Seq_THP-1_Human1.50229032
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46222544
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45972771
46* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43911096
47* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42901400
48TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.42728995
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.42557589
50VDR_22108803_ChIP-Seq_LS180_Human1.40997637
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39942573
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.37769480
53FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37235173
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35960620
55* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35355806
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35044264
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33251310
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.30090410
59CBP_20019798_ChIP-Seq_JUKART_Human1.29916336
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29916336
61PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29368745
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28816969
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28223849
64* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27761761
65MAF_26560356_Chip-Seq_TH1_Human1.25690528
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25541168
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.25373647
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24834998
69CLOCK_20551151_ChIP-Seq_293T_Human1.24400451
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23649607
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23436832
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23236638
73CREB1_26743006_Chip-Seq_LNCaP_Human1.23164557
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.22748509
75SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22573854
76STAT1_17558387_ChIP-Seq_HELA_Human1.21934611
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21269811
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21059682
79MYC_27129775_Chip-Seq_CORNEA_Mouse1.20977673
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20638018
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.20367455
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20261499
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.19593003
84CTCF_27219007_Chip-Seq_Bcells_Human1.19219015
85ZNF263_19887448_ChIP-Seq_K562_Human1.18871634
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18176939
87DROSHA_22980978_ChIP-Seq_HELA_Human1.17996914
88P53_21459846_ChIP-Seq_SAOS-2_Human1.17759978
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17321789
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.16962308
91GATA3_21867929_ChIP-Seq_CD8_Mouse1.16698774
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16481642
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16043792
94MAF_26560356_Chip-Seq_TH2_Human1.15603965
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14968992
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14423575
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13912679
98SPI1_23127762_ChIP-Seq_K562_Human1.12687681
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11028390
100IRF8_22096565_ChIP-ChIP_GC-B_Human1.10888821
101* SMC4_20622854_ChIP-Seq_HELA_Human1.09565652
102* TET1_21490601_ChIP-Seq_MESCs_Mouse1.09394695
103ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09057792
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08898236
105TP53_22127205_ChIP-Seq_IMR90_Human1.07536026
106* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07213276
107GATA1_19941826_ChIP-Seq_K562_Human1.07129443
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06607748
109P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06533633
110SA1_27219007_Chip-Seq_Bcells_Human1.06387034
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06306638
112GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06108817
113NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06054006
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05913223
115RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05445087
116KLF4_19829295_ChIP-Seq_ESCs_Human1.05131627
117KDM2B_26808549_Chip-Seq_REH_Human1.04686900
118RXR_22158963_ChIP-Seq_LIVER_Mouse1.04651690
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04345757
120SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04236956
121CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03720475
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.03425098
123EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03325472
124SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02894912
125EGR1_19374776_ChIP-ChIP_THP-1_Human1.01996007
126UTX_26944678_Chip-Seq_JUKART_Human1.01936263
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01812364
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01668711
129GF1_26923725_Chip-Seq_HPCs_Mouse1.01003122
130MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00481960
131ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00177832
132TP63_22573176_ChIP-Seq_HFKS_Human0.99583671
133* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99311674
134* BCOR_27268052_Chip-Seq_Bcells_Human0.99268049
135OCT4_19829295_ChIP-Seq_ESCs_Human0.98961839
136ATF3_27146783_Chip-Seq_COLON_Human0.98669784
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98088335
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97294067
139* CTCF_20526341_ChIP-Seq_ESCs_Human0.97068099
140CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96931929
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.96814578
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.96360198
143PHF8_20622854_ChIP-Seq_HELA_Human0.96112299
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96009983
145SOX2_21211035_ChIP-Seq_LN229_Human0.95902064
146RARB_27405468_Chip-Seq_BRAIN_Mouse0.95726827
147SPI1_26923725_Chip-Seq_HPCs_Mouse0.95359106
148* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95157644
149YY1_22570637_ChIP-Seq_MALME-3M_Human0.95049256
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.94593217
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94264492
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92898006
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92767291
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92767291
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92662943
156EZH2_27294783_Chip-Seq_ESCs_Mouse0.92541588
157* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92199319
158* TCF7_22412390_ChIP-Seq_EML_Mouse0.91858943
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90900625
160* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90364477
161TBX20_22080862_ChIP-Seq_HEART_Mouse0.90096426
162TBX20_22328084_ChIP-Seq_HEART_Mouse0.90096426
163RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89927048
164LXR_22292898_ChIP-Seq_THP-1_Human0.88467762
165* BCL6_27268052_Chip-Seq_Bcells_Human0.86693630
166RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86391638
167GATA3_21867929_ChIP-Seq_TH1_Mouse0.85763707
168CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85681682
169PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85614832
170* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84802059
171REST_18959480_ChIP-ChIP_MESCs_Mouse0.83753399
172SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83288201
173E2F1_20622854_ChIP-Seq_HELA_Human0.83196817
174OCT1_27270436_Chip-Seq_PROSTATE_Human0.82942478
175SMAD4_21741376_ChIP-Seq_EPCs_Human0.82846547
176SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82341999
177P68_20966046_ChIP-Seq_HELA_Human0.81712262
178NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81512150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.39771365
2MP0001929_abnormal_gametogenesis4.76621685
3MP0005058_abnormal_lysosome_morphology3.49840966
4MP0008877_abnormal_DNA_methylation3.44342327
5MP0002161_abnormal_fertility/fecundity2.92588075
6MP0005451_abnormal_body_composition2.86380068
7MP0005670_abnormal_white_adipose2.84377360
8MP0002210_abnormal_sex_determination2.81640605
9MP0009840_abnormal_foam_cell2.68402609
10MP0008438_abnormal_cutaneous_collagen2.59056936
11MP0003646_muscle_fatigue2.47163020
12MP0001145_abnormal_male_reproductive2.43588477
13MP0002653_abnormal_ependyma_morphology2.42093681
14MP0003436_decreased_susceptibility_to2.20134491
15MP0003279_aneurysm2.09434337
16MP0000653_abnormal_sex_gland2.05841132
17MP0004233_abnormal_muscle_weight2.00236369
18MP0005410_abnormal_fertilization14.9995731
19MP0005623_abnormal_meninges_morphology1.89619203
20MP0003191_abnormal_cellular_cholesterol1.88489326
21MP0003091_abnormal_cell_migration1.84841275
22MP0004859_abnormal_synaptic_plasticity1.74532930
23MP0001958_emphysema1.67767260
24MP0003453_abnormal_keratinocyte_physiol1.64405498
25MP0004185_abnormal_adipocyte_glucose1.62570410
26MP0008260_abnormal_autophagy1.53217799
27MP0002160_abnormal_reproductive_system1.51837490
28MP0002998_abnormal_bone_remodeling1.48885324
29MP0000003_abnormal_adipose_tissue1.44054110
30MP0003566_abnormal_cell_adhesion1.44040605
31MP0004947_skin_inflammation1.42425068
32MP0001533_abnormal_skeleton_physiology1.41676269
33MP0000678_abnormal_parathyroid_gland1.37970132
34MP0003690_abnormal_glial_cell1.36005490
35MP0006082_CNS_inflammation1.35287026
36MP0003329_amyloid_beta_deposits1.33892391
37MP0000343_altered_response_to1.31946008
38MP0008961_abnormal_basal_metabolism1.30995190
39MP0000747_muscle_weakness1.25674989
40MP0002419_abnormal_innate_immunity1.25401354
41MP0005409_darkened_coat_color1.24354244
42MP0005257_abnormal_intraocular_pressure1.24296069
43MP0000751_myopathy1.23920662
44MP0001765_abnormal_ion_homeostasis1.20437508
45MP0005387_immune_system_phenotype1.18442621
46MP0001790_abnormal_immune_system1.18442621
47MP0005275_abnormal_skin_tensile1.17525877
48MP0000685_abnormal_immune_system1.16924799
49MP0003828_pulmonary_edema1.13455567
50MP0000767_abnormal_smooth_muscle1.13261823
51MP0005025_abnormal_response_to1.12854454
52MP0000569_abnormal_digit_pigmentation1.12731762
53MP0005166_decreased_susceptibility_to1.12001586
54MP0005503_abnormal_tendon_morphology1.11389921
55MP0002909_abnormal_adrenal_gland1.11281725
56MP0005000_abnormal_immune_tolerance1.10991754
57MP0003724_increased_susceptibility_to1.10791062
58MP0004270_analgesia1.08982918
59MP0009046_muscle_twitch1.07841953
60MP0002877_abnormal_melanocyte_morpholog1.07449547
61MP0000858_altered_metastatic_potential1.06446716
62MP0003448_altered_tumor_morphology1.05040288
63MP0009785_altered_susceptibility_to1.04012758
64MP0005023_abnormal_wound_healing1.03268828
65MP0002234_abnormal_pharynx_morphology1.03147589
66MP0002148_abnormal_hypersensitivity_rea1.03024205
67MP0002933_joint_inflammation1.02868642
68MP0003115_abnormal_respiratory_system1.02168806
69MP0002254_reproductive_system_inflammat1.01903964
70MP0004130_abnormal_muscle_cell1.01824419
71MP0005666_abnormal_adipose_tissue1.00855232
72MP0002249_abnormal_larynx_morphology0.99917425
73MP0005390_skeleton_phenotype0.95689836
74MP0002896_abnormal_bone_mineralization0.95468913
75MP0004036_abnormal_muscle_relaxation0.93531486
76MP0003635_abnormal_synaptic_transmissio0.92162778
77MP0008874_decreased_physiological_sensi0.92005458
78MP0006138_congestive_heart_failure0.91525481
79MP0002282_abnormal_trachea_morphology0.91314205
80MP0002269_muscular_atrophy0.90125723
81MP0001835_abnormal_antigen_presentation0.89806168
82MP0005310_abnormal_salivary_gland0.89555714
83MP0009333_abnormal_splenocyte_physiolog0.89328362
84MP0000920_abnormal_myelination0.87987396
85MP0000249_abnormal_blood_vessel0.86210479
86MP0000604_amyloidosis0.86208344
87MP0000750_abnormal_muscle_regeneration0.86045457
88MP0002332_abnormal_exercise_endurance0.85459642
89MP0001984_abnormal_olfaction0.84581217
90MP0004811_abnormal_neuron_physiology0.83531581
91MP0003879_abnormal_hair_cell0.83154130
92MP0002796_impaired_skin_barrier0.82060696
93MP0009384_cardiac_valve_regurgitation0.80797736
94MP0009278_abnormal_bone_marrow0.79513638
95MP0002060_abnormal_skin_morphology0.79354702
96MP0003283_abnormal_digestive_organ0.79186137
97MP0005595_abnormal_vascular_smooth0.78486188
98MP0002452_abnormal_antigen_presenting0.77473147
99MP0002822_catalepsy0.76590381
100MP0002723_abnormal_immune_serum0.76336456
101MP0003045_fibrosis0.76317888
102MP0003183_abnormal_peptide_metabolism0.75577177
103MP0002063_abnormal_learning/memory/cond0.75241775
104MP0003705_abnormal_hypodermis_morpholog0.74684540
105MP0005464_abnormal_platelet_physiology0.74184519
106MP0004858_abnormal_nervous_system0.74050397
107MP0002970_abnormal_white_adipose0.73445484
108MP0004087_abnormal_muscle_fiber0.73425137
109MP0005375_adipose_tissue_phenotype0.68441570
110MP0000534_abnormal_ureter_morphology0.64174151
111MP0003633_abnormal_nervous_system0.62841153
112MP0001849_ear_inflammation0.61976864
113MP0002837_dystrophic_cardiac_calcinosis0.61181197
114MP0004145_abnormal_muscle_electrophysio0.60214167
115MP0008569_lethality_at_weaning0.58702486
116MP0009780_abnormal_chondrocyte_physiolo0.58523293
117MP0005377_hearing/vestibular/ear_phenot0.58420035
118MP0003878_abnormal_ear_physiology0.58420035
119MP0000749_muscle_degeneration0.56561557
120MP0005389_reproductive_system_phenotype0.54507596
121MP0002572_abnormal_emotion/affect_behav0.53956845
122MP0002106_abnormal_muscle_physiology0.52830014
123MP0003303_peritoneal_inflammation0.52468763
124MP0003300_gastrointestinal_ulcer0.50984220
125MP0002928_abnormal_bile_duct0.50886426
126MP0002971_abnormal_brown_adipose0.50771176
127MP0000358_abnormal_cell_content/0.50611669
128MP0004510_myositis0.50029914
129MP0005423_abnormal_somatic_nervous0.49895091
130MP0000013_abnormal_adipose_tissue0.48587367
131MP0005647_abnormal_sex_gland0.48021413
132MP0004084_abnormal_cardiac_muscle0.47349881
133MP0009115_abnormal_fat_cell0.46977620
134MP0009745_abnormal_behavioral_response0.45843754
135MP0000759_abnormal_skeletal_muscle0.45482730
136MP0005076_abnormal_cell_differentiation0.44431317
137MP0010630_abnormal_cardiac_muscle0.44044317
138MP0001440_abnormal_grooming_behavior0.43444116
139MP0002064_seizures0.43124646
140MP0005397_hematopoietic_system_phenotyp0.43069497
141MP0001545_abnormal_hematopoietic_system0.43069497
142MP0003631_nervous_system_phenotype0.42948044
143MP0002152_abnormal_brain_morphology0.42732459
144MP0004043_abnormal_pH_regulation0.41525714
145MP0005535_abnormal_body_temperature0.41233365
146MP0003172_abnormal_lysosome_physiology0.40024023
147MP0005636_abnormal_mineral_homeostasis0.37661196
148MP0001348_abnormal_lacrimal_gland0.37582859
149MP0001968_abnormal_touch/_nociception0.36700356
150MP0003948_abnormal_gas_homeostasis0.36406574
151MP0005369_muscle_phenotype0.35606989
152MP0000955_abnormal_spinal_cord0.35546680
153MP0002295_abnormal_pulmonary_circulatio0.35443439
154MP0000733_abnormal_muscle_development0.34866009
155MP0002108_abnormal_muscle_morphology0.34686148
156MP0008995_early_reproductive_senescence0.34542093
157MP0003942_abnormal_urinary_system0.33922723
158MP0005620_abnormal_muscle_contractility0.32321824
159MP0003634_abnormal_glial_cell0.32105097
160MP0003959_abnormal_lean_body0.31580687
161MP0005167_abnormal_blood-brain_barrier0.30818856
162MP0002736_abnormal_nociception_after0.30603993
163MP0003699_abnormal_female_reproductive0.29931755
164MP0003787_abnormal_imprinting0.29531359
165MP0003075_altered_response_to0.29091887

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.95471266
2Abnormal respiratory epithelium morphology (HP:0012253)7.77933257
3Abnormal respiratory motile cilium morphology (HP:0005938)7.77933257
4Rhinitis (HP:0012384)6.87723700
5Infertility (HP:0000789)6.73230003
6Chronic bronchitis (HP:0004469)6.49049029
7Nasal polyposis (HP:0100582)6.36931986
8Abnormal ciliary motility (HP:0012262)5.86145204
9Abnormality of the nasal mucosa (HP:0000433)5.34063513
10Male infertility (HP:0003251)4.61923779
11Bronchitis (HP:0012387)4.21929052
12Bronchiectasis (HP:0002110)3.97571099
13Nephronophthisis (HP:0000090)3.86930368
14Obstructive sleep apnea (HP:0002870)3.18868716
15Abnormality of the lower motor neuron (HP:0002366)3.18194355
16Protrusio acetabuli (HP:0003179)3.17595814
17Recurrent otitis media (HP:0000403)3.04312679
18Dysostosis multiplex (HP:0000943)3.03394167
19Type 1 muscle fiber predominance (HP:0003803)3.02231410
20Increased connective tissue (HP:0009025)2.94940075
21Premature rupture of membranes (HP:0001788)2.92976839
22Cerebral aneurysm (HP:0004944)2.92936324
23Abnormal spermatogenesis (HP:0008669)2.92072091
24Distal lower limb muscle weakness (HP:0009053)2.90189323
25Abnormality of glycolipid metabolism (HP:0010969)2.89147585
26Abnormality of liposaccharide metabolism (HP:0010968)2.89147585
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.89147585
28Distal lower limb amyotrophy (HP:0008944)2.88634341
29Abnormality of the renal medulla (HP:0100957)2.82920355
30Axonal loss (HP:0003447)2.80327342
31Increased variability in muscle fiber diameter (HP:0003557)2.78334180
32Nuclear cataract (HP:0100018)2.73118936
33Recurrent bronchitis (HP:0002837)2.70515735
34Abnormality of skeletal muscle fiber size (HP:0012084)2.70376130
35Vertebral compression fractures (HP:0002953)2.68395932
36Tubular atrophy (HP:0000092)2.64717766
37Abnormality of polysaccharide metabolism (HP:0011012)2.60383857
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60383857
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60383857
40Urinary glycosaminoglycan excretion (HP:0003541)2.59720175
41Mucopolysacchariduria (HP:0008155)2.59720175
42Cholecystitis (HP:0001082)2.56783814
43Abnormal gallbladder physiology (HP:0012438)2.56783814
44Centrally nucleated skeletal muscle fibers (HP:0003687)2.52921505
45Spastic tetraparesis (HP:0001285)2.52229842
46Cervical subluxation (HP:0003308)2.44995343
47Recurrent sinusitis (HP:0011108)2.43919458
48Gonadotropin excess (HP:0000837)2.38244529
49Amyotrophic lateral sclerosis (HP:0007354)2.38112064
50Systemic lupus erythematosus (HP:0002725)2.37880394
51Spinal rigidity (HP:0003306)2.34152039
52Thin bony cortex (HP:0002753)2.33876008
53Broad face (HP:0000283)2.30069457
54Mildly elevated creatine phosphokinase (HP:0008180)2.29870606
55Achilles tendon contracture (HP:0001771)2.29144379
56Bundle branch block (HP:0011710)2.27971785
57Bulbar palsy (HP:0001283)2.25251717
58Tubulointerstitial abnormality (HP:0001969)2.25050538
59Exercise-induced myalgia (HP:0003738)2.23338942
60Neurofibrillary tangles (HP:0002185)2.22441368
61Heterotopia (HP:0002282)2.21360769
62Hyperacusis (HP:0010780)2.19865372
63Asymmetric septal hypertrophy (HP:0001670)2.18803434
64Impulsivity (HP:0100710)2.18403349
65Tubulointerstitial fibrosis (HP:0005576)2.17557851
66Lower limb amyotrophy (HP:0007210)2.16227203
67Increased cerebral lipofuscin (HP:0011813)2.13157590
68Myopathic facies (HP:0002058)2.12623021
69Hypertriglyceridemia (HP:0002155)2.11259919
70Cerebral inclusion bodies (HP:0100314)2.10986390
71Atrophic scars (HP:0001075)2.10841337
72Tubulointerstitial nephritis (HP:0001970)2.10016560
73Choroideremia (HP:0001139)2.08651217
74Muscle fiber inclusion bodies (HP:0100299)2.07447697
75Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05039666
76Muscle fiber splitting (HP:0003555)2.03506899
77Stridor (HP:0010307)2.03501183
78Abnormality of the Achilles tendon (HP:0005109)2.03095987
79Round ear (HP:0100830)2.02926493
80Difficulty climbing stairs (HP:0003551)2.02272567
81Abnormality of macrophages (HP:0004311)2.01645367
82Ulnar deviation of the wrist (HP:0003049)2.00381311
83Dynein arm defect of respiratory motile cilia (HP:0012255)11.6341144
84Absent/shortened dynein arms (HP:0200106)11.6341144
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.5158789
86Nemaline bodies (HP:0003798)1.99625885
87Azoospermia (HP:0000027)1.98575350
88Polydipsia (HP:0001959)1.97974602
89Abnormal drinking behavior (HP:0030082)1.97974602
90Abnormality of midbrain morphology (HP:0002418)1.95694613
91Molar tooth sign on MRI (HP:0002419)1.95694613
92Eczematoid dermatitis (HP:0000976)1.94641118
93Aneurysm (HP:0002617)1.94327342
94Fragile skin (HP:0001030)1.92808543
95Hyporeflexia of lower limbs (HP:0002600)1.88294731
96Acanthosis nigricans (HP:0000956)1.84869088
97Emphysema (HP:0002097)1.83740863
98Blue sclerae (HP:0000592)1.83607631
99Myoglobinuria (HP:0002913)1.83429811
100Joint stiffness (HP:0001387)1.82833750
101Shallow orbits (HP:0000586)1.82832457
102Hypercortisolism (HP:0001578)1.82185368
103Dilatation of the ascending aorta (HP:0005111)1.81738383
104Gingivitis (HP:0000230)1.81544863
105Loss of speech (HP:0002371)1.80770348
106Long palpebral fissure (HP:0000637)1.80650354
107Mitral regurgitation (HP:0001653)1.80587132
108Slender build (HP:0001533)1.80227291
109Difficulty running (HP:0009046)1.77418257
110Hyperparathyroidism (HP:0000843)1.77339400
111Hemorrhage of the eye (HP:0011885)1.77335139
112Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76974111
113Stage 5 chronic kidney disease (HP:0003774)1.74867102
114Bell-shaped thorax (HP:0001591)1.74501244
115Dyschromatopsia (HP:0007641)1.74078738
116Deformed sella turcica (HP:0002681)1.73483358
117Hand muscle atrophy (HP:0009130)1.73082821
118Segmental peripheral demyelination/remyelination (HP:0003481)1.73075934
119Aortic aneurysm (HP:0004942)1.72945449
120Hemiparesis (HP:0001269)1.72874611
121EMG: neuropathic changes (HP:0003445)1.72677866
122Apathy (HP:0000741)1.72255942
123Supranuclear gaze palsy (HP:0000605)1.71998813
124Slow saccadic eye movements (HP:0000514)1.71573970
125Vascular tortuosity (HP:0004948)1.70953834
126Absent frontal sinuses (HP:0002688)1.70292133
127Dysmetric saccades (HP:0000641)1.69220212
128Malnutrition (HP:0004395)1.67311716
129Amyloidosis (HP:0011034)1.67063378
130Neuronal loss in central nervous system (HP:0002529)1.66975837
131Spondylolisthesis (HP:0003302)1.65463682
132Peritonitis (HP:0002586)1.65193901
133Myocardial infarction (HP:0001658)1.64835639
134Abnormality of renal excretion (HP:0011036)1.64806045
135Global brain atrophy (HP:0002283)1.64742512
136Distal upper limb amyotrophy (HP:0007149)1.64689930
137Upper limb amyotrophy (HP:0009129)1.64689930
138Generalized amyotrophy (HP:0003700)1.63927285
139Cellulitis (HP:0100658)1.63255605
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.62866898
141Bladder diverticulum (HP:0000015)1.62844261
142Rapidly progressive (HP:0003678)1.62396804
143Diminished motivation (HP:0000745)1.62093115
144Genu recurvatum (HP:0002816)1.62035800
145Neoplasm of the heart (HP:0100544)1.61327327
146Ankle contracture (HP:0006466)1.59802963
147J-shaped sella turcica (HP:0002680)1.59643775
148Exercise-induced muscle cramps (HP:0003710)1.57125526
149Polycythemia (HP:0001901)1.56565327
150Arterial tortuosity (HP:0005116)1.55083818
151Foot dorsiflexor weakness (HP:0009027)1.54857814
152Impaired vibration sensation in the lower limbs (HP:0002166)1.54531238
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54414626
154Abnormality of ocular smooth pursuit (HP:0000617)1.53326879
155Retinal atrophy (HP:0001105)1.52726751
156Short ribs (HP:0000773)1.51796461
157Easy fatigability (HP:0003388)1.51079534
158Medial flaring of the eyebrow (HP:0010747)1.48124198
159Abnormal urine output (HP:0012590)1.47988940
160Postural instability (HP:0002172)1.47945043
161Pachygyria (HP:0001302)1.47164411
162Abnormality of saccadic eye movements (HP:0000570)1.45330713
163Oculomotor apraxia (HP:0000657)1.42943910
164Decreased electroretinogram (ERG) amplitude (HP:0000654)1.42171853
165Broad distal phalanx of finger (HP:0009836)1.41716737
166Impaired proprioception (HP:0010831)1.41634204
167Buphthalmos (HP:0000557)1.40494803
168Abnormality of dentin (HP:0010299)1.39861016
169Renal dysplasia (HP:0000110)1.34520447
170Generalized muscle weakness (HP:0003324)1.33161781
171Polymicrogyria (HP:0002126)1.32719185
172Hyperkalemia (HP:0002153)1.32599848
173Renovascular hypertension (HP:0100817)1.32099677
174Fatigable weakness (HP:0003473)1.31723584
175Abnormality of the neuromuscular junction (HP:0003398)1.31723584
176Congenital hepatic fibrosis (HP:0002612)1.30203718
177Fibular hypoplasia (HP:0003038)1.29269328
178Truncal obesity (HP:0001956)1.28411381
179Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.27631126
180Abnormality of vision evoked potentials (HP:0000649)1.26807022
181Postaxial foot polydactyly (HP:0001830)1.25818158
182Polyuria (HP:0000103)1.25758272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.15534628
2PDK37.15534628
3PRKD36.80127729
4ICK5.26126027
5PDK24.45659714
6PRPF4B3.04570996
7SIK12.81843233
8PTK2B2.62452012
9STK382.51522968
10IRAK32.40947964
11WNK42.16721954
12TRIB31.95036942
13PNCK1.88357393
14TAOK21.70959124
15SMG11.70890778
16MAP3K111.66572444
17DYRK1B1.61611118
18NEK21.55337446
19STK391.54612422
20TYRO31.49575215
21MAP2K31.47868415
22MAP3K131.47042401
23MAP3K31.44855160
24PDK11.37640086
25NME21.30708835
26EEF2K1.23770289
27TNK21.22793133
28TBK11.20814226
29ARAF1.19163066
30FGFR41.14911119
31CAMKK11.10468599
32MAP4K11.10112047
33CAMK1G1.09001118
34TYK21.02119802
35MOS1.01725726
36TGFBR21.01346440
37WNK11.00989831
38CAMK1D1.00513938
39PDPK11.00468573
40RIPK40.91316508
41MAPK120.90568852
42CSK0.89123972
43TAOK10.86108383
44MST1R0.85094719
45SIK30.83475187
46RIPK10.81602093
47PAK60.81069039
48BLK0.80431601
49NTRK20.79915213
50LMTK20.79815120
51MAPK150.78731705
52RPS6KL10.78209940
53RPS6KC10.78209940
54PKN20.75922697
55MAP3K90.75357902
56PINK10.74044863
57MAP3K100.73295939
58IRAK40.72450693
59JAK30.71345483
60PIM20.71137424
61MAP3K140.70684097
62MARK10.69652428
63HIPK20.69452043
64MAPK70.69104891
65EPHA20.65392247
66MARK20.63983827
67MAPK40.62041226
68TTN0.61165905
69STK30.60876467
70MAP3K60.60589507
71MTOR0.60345343
72ERN10.58470352
73ABL20.57809799
74MAP3K70.57572955
75MAPK110.55926209
76RPS6KA60.55331478
77PASK0.54978846
78DAPK20.52880710
79JAK10.52533445
80NTRK30.51639220
81SGK30.51012175
82MAP2K60.50504823
83BRAF0.50400344
84KSR20.49897574
85PAK20.49871052
86MAP3K40.47223054
87PTK60.47182032
88EPHA40.47138284
89PRKCG0.45485135
90PRKAA20.45154467
91CCNB10.45088876
92PRKAA10.43731050
93MUSK0.43282039
94EPHB20.42301361
95MINK10.41967178
96PIK3CG0.41737523
97CHUK0.40679594
98STK110.40166129
99ROCK10.39702831
100PAK40.39518397
101MAP3K80.38173623
102PHKG20.37558706
103PHKG10.37558706
104MAP3K10.37339022
105ROCK20.36146361
106OBSCN0.35660060
107IKBKB0.35630390
108RET0.35296108
109IRAK10.34545250
110TESK20.34314355
111PRKCZ0.33543455
112DYRK30.33382438
113SIK20.33218635
114NTRK10.32696485
115PRKCH0.32277178
116PAK10.32148282
117PDGFRA0.30931029
118MAP3K20.29771298
119CDK50.26597602
120EPHB10.26176733
121BMX0.25181092
122DMPK0.23207395
123RPS6KA10.22958135
124PDGFRB0.22531017
125CDK150.22291200
126MAP2K40.21254818
127LATS20.19532575
128CHEK10.19141967
129IRAK20.18440179
130CDK180.18047331
131RPS6KA20.17591274
132ALK0.17405350
133CDK120.17276709
134RPS6KB10.16734935
135RPS6KA30.15833370
136CHEK20.15826127
137MAPK80.15797155
138CDK11A0.15743088
139CDK140.15230439
140DDR20.14971968
141PRKACG0.14006797
142CAMK10.12878181
143PRKD20.12455136
144PTK20.12449400
145TTK0.11832077
146CDC42BPA0.11542808
147EGFR0.11256720
148SRC0.09381154
149CSF1R0.09163310
150MAP3K50.08888489
151PRKG20.08772436
152ZAP700.08216126

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.39427893
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.04986137
3Other glycan degradation_Homo sapiens_hsa005112.54712336
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.46577000
5Glucagon signaling pathway_Homo sapiens_hsa049222.45562111
6Carbohydrate digestion and absorption_Homo sapiens_hsa049732.44675804
7Pyruvate metabolism_Homo sapiens_hsa006202.31792667
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29168557
9Dorso-ventral axis formation_Homo sapiens_hsa043202.17999818
10Amphetamine addiction_Homo sapiens_hsa050311.99784673
11Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.84384697
12Vitamin B6 metabolism_Homo sapiens_hsa007501.82056697
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78473171
14Propanoate metabolism_Homo sapiens_hsa006401.74167036
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74114178
16Osteoclast differentiation_Homo sapiens_hsa043801.69970675
17Acute myeloid leukemia_Homo sapiens_hsa052211.62615557
18Glycerolipid metabolism_Homo sapiens_hsa005611.61982637
19PPAR signaling pathway_Homo sapiens_hsa033201.60778538
20Long-term potentiation_Homo sapiens_hsa047201.59750288
21Renin secretion_Homo sapiens_hsa049241.58328589
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55959610
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52975188
24Linoleic acid metabolism_Homo sapiens_hsa005911.51735314
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51352447
26Lysosome_Homo sapiens_hsa041421.48934906
27Notch signaling pathway_Homo sapiens_hsa043301.48298128
28Insulin secretion_Homo sapiens_hsa049111.44346206
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42767928
30Prion diseases_Homo sapiens_hsa050201.38033280
31Oocyte meiosis_Homo sapiens_hsa041141.37920832
32Estrogen signaling pathway_Homo sapiens_hsa049151.35564056
33Selenocompound metabolism_Homo sapiens_hsa004501.35133841
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33010907
35Synaptic vesicle cycle_Homo sapiens_hsa047211.30893651
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.30337579
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.26908797
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26326829
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24611280
40TNF signaling pathway_Homo sapiens_hsa046681.23481282
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21766829
42Chronic myeloid leukemia_Homo sapiens_hsa052201.21213051
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.20761026
44Cardiac muscle contraction_Homo sapiens_hsa042601.20580479
45Type II diabetes mellitus_Homo sapiens_hsa049301.15543962
46Fructose and mannose metabolism_Homo sapiens_hsa000511.14620081
47Fat digestion and absorption_Homo sapiens_hsa049751.14406520
48Bladder cancer_Homo sapiens_hsa052191.13632950
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13491596
50Leishmaniasis_Homo sapiens_hsa051401.13453252
51Gastric acid secretion_Homo sapiens_hsa049711.13075709
52Circadian entrainment_Homo sapiens_hsa047131.12542260
53Fatty acid metabolism_Homo sapiens_hsa012121.11454537
54Fatty acid degradation_Homo sapiens_hsa000711.10251079
55Tuberculosis_Homo sapiens_hsa051521.08953871
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.08764705
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08624573
58Malaria_Homo sapiens_hsa051441.08559958
59VEGF signaling pathway_Homo sapiens_hsa043701.06730341
60Amoebiasis_Homo sapiens_hsa051461.06499051
61Salivary secretion_Homo sapiens_hsa049701.06310468
62GnRH signaling pathway_Homo sapiens_hsa049121.06038290
63Focal adhesion_Homo sapiens_hsa045101.01664280
64Non-small cell lung cancer_Homo sapiens_hsa052231.00877161
65Bile secretion_Homo sapiens_hsa049761.00412781
66Central carbon metabolism in cancer_Homo sapiens_hsa052301.00410832
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99093491
68Carbon metabolism_Homo sapiens_hsa012000.95163433
69Pertussis_Homo sapiens_hsa051330.93181613
70Influenza A_Homo sapiens_hsa051640.93038593
71Olfactory transduction_Homo sapiens_hsa047400.93014002
72Cocaine addiction_Homo sapiens_hsa050300.92232689
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92005244
74Mineral absorption_Homo sapiens_hsa049780.91801607
75Viral myocarditis_Homo sapiens_hsa054160.91637935
76Staphylococcus aureus infection_Homo sapiens_hsa051500.91349944
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.89729202
78Thyroid hormone synthesis_Homo sapiens_hsa049180.89613610
79Allograft rejection_Homo sapiens_hsa053300.89581402
80Calcium signaling pathway_Homo sapiens_hsa040200.88187287
81Renal cell carcinoma_Homo sapiens_hsa052110.88060275
82AMPK signaling pathway_Homo sapiens_hsa041520.87159334
83Prolactin signaling pathway_Homo sapiens_hsa049170.86973718
84Endocytosis_Homo sapiens_hsa041440.86501611
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84315431
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83979708
87Hepatitis C_Homo sapiens_hsa051600.83333265
88Pancreatic cancer_Homo sapiens_hsa052120.82706466
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81886409
90Pentose phosphate pathway_Homo sapiens_hsa000300.81874719
91Chemokine signaling pathway_Homo sapiens_hsa040620.79987840
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.79801039
93Dopaminergic synapse_Homo sapiens_hsa047280.79390578
94ErbB signaling pathway_Homo sapiens_hsa040120.79390191
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.78759555
96Oxytocin signaling pathway_Homo sapiens_hsa049210.78311972
97Nitrogen metabolism_Homo sapiens_hsa009100.78296743
98cAMP signaling pathway_Homo sapiens_hsa040240.77870658
99Endometrial cancer_Homo sapiens_hsa052130.77041798
100Insulin resistance_Homo sapiens_hsa049310.76777030
101Glutamatergic synapse_Homo sapiens_hsa047240.76337032
102T cell receptor signaling pathway_Homo sapiens_hsa046600.75060126
103Proteoglycans in cancer_Homo sapiens_hsa052050.73471425
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.73355069
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73212891
106Hepatitis B_Homo sapiens_hsa051610.73135255
107Autoimmune thyroid disease_Homo sapiens_hsa053200.73027839
108Graft-versus-host disease_Homo sapiens_hsa053320.72192510
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71074816
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70637223
111Pancreatic secretion_Homo sapiens_hsa049720.70322419
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69503785
113Phagosome_Homo sapiens_hsa041450.69383603
114Hedgehog signaling pathway_Homo sapiens_hsa043400.68370867
115Antigen processing and presentation_Homo sapiens_hsa046120.67172424
116ECM-receptor interaction_Homo sapiens_hsa045120.62479998
117Insulin signaling pathway_Homo sapiens_hsa049100.62410692
118Choline metabolism in cancer_Homo sapiens_hsa052310.61177831
119Platelet activation_Homo sapiens_hsa046110.60999227
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60020131
121Vibrio cholerae infection_Homo sapiens_hsa051100.59362186
122B cell receptor signaling pathway_Homo sapiens_hsa046620.59327735
123Phenylalanine metabolism_Homo sapiens_hsa003600.59048295
124Thyroid cancer_Homo sapiens_hsa052160.58012166
125mTOR signaling pathway_Homo sapiens_hsa041500.57268690
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.57095727
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56122327
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55674596
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55063289
130Collecting duct acid secretion_Homo sapiens_hsa049660.54776727
131Apoptosis_Homo sapiens_hsa042100.54681778
132Rheumatoid arthritis_Homo sapiens_hsa053230.54286718
133Measles_Homo sapiens_hsa051620.53498302
134Inositol phosphate metabolism_Homo sapiens_hsa005620.51368300
135Morphine addiction_Homo sapiens_hsa050320.49907106
136Taste transduction_Homo sapiens_hsa047420.49003794
137Protein digestion and absorption_Homo sapiens_hsa049740.48408184
138Glioma_Homo sapiens_hsa052140.48023166
139Cholinergic synapse_Homo sapiens_hsa047250.46639872
140Ether lipid metabolism_Homo sapiens_hsa005650.43706068
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.43244265
142HIF-1 signaling pathway_Homo sapiens_hsa040660.42407713
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.40814971
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39345261
145ABC transporters_Homo sapiens_hsa020100.39249844
146mRNA surveillance pathway_Homo sapiens_hsa030150.38080926
147Biosynthesis of amino acids_Homo sapiens_hsa012300.37983013
148Salmonella infection_Homo sapiens_hsa051320.37853496
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37582606
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37140840
151MAPK signaling pathway_Homo sapiens_hsa040100.36829245
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36400749
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35161266
154Alcoholism_Homo sapiens_hsa050340.33520995
155Dilated cardiomyopathy_Homo sapiens_hsa054140.33491264
156Legionellosis_Homo sapiens_hsa051340.32930854
157Toxoplasmosis_Homo sapiens_hsa051450.32086641

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