TESK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.43332734
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.43332734
3L-phenylalanine metabolic process (GO:0006558)5.17244063
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.17244063
5serine family amino acid biosynthetic process (GO:0009070)4.62517872
6positive regulation of gamma-delta T cell activation (GO:0046645)4.58658790
7central nervous system myelination (GO:0022010)4.57096091
8axon ensheathment in central nervous system (GO:0032291)4.57096091
9L-serine metabolic process (GO:0006563)4.43941127
10fatty acid elongation (GO:0030497)4.39445423
11aromatic amino acid family catabolic process (GO:0009074)4.36966142
12antigen processing and presentation of endogenous antigen (GO:0019883)4.24038615
13negative regulation of cell killing (GO:0031342)4.17768493
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17768493
15cysteine metabolic process (GO:0006534)4.14381025
16sulfur amino acid catabolic process (GO:0000098)4.14190372
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03597101
18neutrophil activation involved in immune response (GO:0002283)4.03549308
19response to peptidoglycan (GO:0032494)4.02770659
20glycine metabolic process (GO:0006544)3.97515071
21serine family amino acid metabolic process (GO:0009069)3.93058399
22heme transport (GO:0015886)3.91636470
23cellular extravasation (GO:0045123)3.90213953
24positive regulation by symbiont of host defense response (GO:0052509)3.89903394
25modulation by symbiont of host defense response (GO:0052031)3.89903394
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.89903394
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.89903394
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.89903394
29modulation by symbiont of host immune response (GO:0052553)3.89903394
30cholesterol biosynthetic process (GO:0006695)3.84780697
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.79406974
32regulation of gamma-delta T cell activation (GO:0046643)3.78485321
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.76966768
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75323229
35detection of other organism (GO:0098543)3.71417455
36glyoxylate metabolic process (GO:0046487)3.70046759
37macrophage activation involved in immune response (GO:0002281)3.68865798
38immunoglobulin mediated immune response (GO:0016064)3.68828215
39serine family amino acid catabolic process (GO:0009071)3.68795491
40regulation of B cell receptor signaling pathway (GO:0050855)3.64979719
41regulation of interferon-beta biosynthetic process (GO:0045357)3.58027296
42regulation of triglyceride catabolic process (GO:0010896)3.54257642
43detection of bacterium (GO:0016045)3.53579069
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.51530520
45urea metabolic process (GO:0019627)3.50726052
46urea cycle (GO:0000050)3.50726052
47bile acid biosynthetic process (GO:0006699)3.50634695
48regulation of gamma-delta T cell differentiation (GO:0045586)3.46100737
49phospholipid efflux (GO:0033700)3.41483285
50respiratory burst (GO:0045730)3.38006985
51indole-containing compound catabolic process (GO:0042436)3.37295326
52indolalkylamine catabolic process (GO:0046218)3.37295326
53tryptophan catabolic process (GO:0006569)3.37295326
54alpha-linolenic acid metabolic process (GO:0036109)3.35712263
55negative regulation of interleukin-12 production (GO:0032695)3.35123479
56negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.34356731
57sterol biosynthetic process (GO:0016126)3.34241717
58positive regulation of triglyceride lipase activity (GO:0061365)3.33945622
59positive regulation of lipoprotein lipase activity (GO:0051006)3.33945622
60nitrogen cycle metabolic process (GO:0071941)3.33214113
61regulation of bile acid biosynthetic process (GO:0070857)3.30865692
62mannose metabolic process (GO:0006013)3.30716523
63folic acid metabolic process (GO:0046655)3.27038873
64production of molecular mediator involved in inflammatory response (GO:0002532)3.26776783
65aromatic amino acid family metabolic process (GO:0009072)3.26314907
66fusion of sperm to egg plasma membrane (GO:0007342)3.24795170
67kynurenine metabolic process (GO:0070189)3.24662023
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.22085578
69intestinal cholesterol absorption (GO:0030299)3.21113662
70tryptophan metabolic process (GO:0006568)3.20914121
71bile acid metabolic process (GO:0008206)3.20584037
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17851279
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16970264
74B cell mediated immunity (GO:0019724)3.15944137
75neutrophil activation (GO:0042119)3.15819566
76homocysteine metabolic process (GO:0050667)3.15755710
77detection of external biotic stimulus (GO:0098581)3.15498244
78positive thymic T cell selection (GO:0045059)3.14255392
79detection of molecule of bacterial origin (GO:0032490)3.12277699
80myeloid cell activation involved in immune response (GO:0002275)3.11965469
81B cell receptor signaling pathway (GO:0050853)3.11517003
82high-density lipoprotein particle remodeling (GO:0034375)3.11054932
83granulocyte activation (GO:0036230)3.07967087
84negative regulation of toll-like receptor signaling pathway (GO:0034122)3.07238631
85G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.01942105
86regulation of cholesterol esterification (GO:0010872)3.00009446
87positive regulation of interferon-alpha production (GO:0032727)2.99720623
88alpha-amino acid catabolic process (GO:1901606)2.99051408
89glutathione derivative metabolic process (GO:1901685)2.98786642
90glutathione derivative biosynthetic process (GO:1901687)2.98786642
91negative regulation of cholesterol transport (GO:0032375)2.98697520
92negative regulation of sterol transport (GO:0032372)2.98697520
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98162798
94intestinal absorption (GO:0050892)2.97590749
95very-low-density lipoprotein particle assembly (GO:0034379)2.97334334
96negative regulation of fibrinolysis (GO:0051918)2.96830927
97germinal center formation (GO:0002467)2.96652238
98pyrimidine-containing compound transmembrane transport (GO:0072531)2.96044268
99response to nitrosative stress (GO:0051409)2.95796712
100amino-acid betaine metabolic process (GO:0006577)2.94793126
101coenzyme catabolic process (GO:0009109)2.94502668
102positive regulation of humoral immune response (GO:0002922)2.94177281
103tyrosine metabolic process (GO:0006570)2.92253633
104ethanol oxidation (GO:0006069)2.92231165
105alpha-amino acid biosynthetic process (GO:1901607)2.90963576
106cellular amino acid catabolic process (GO:0009063)2.90510858
107regulation of mast cell degranulation (GO:0043304)2.90067800
108cholesterol homeostasis (GO:0042632)2.89803751
109response to muramyl dipeptide (GO:0032495)2.89290299
110negative regulation of erythrocyte differentiation (GO:0045647)2.87983639
111sterol homeostasis (GO:0055092)2.86858528
112lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84789522
113very long-chain fatty acid metabolic process (GO:0000038)2.84252932
114positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.83218060
115negative thymic T cell selection (GO:0045060)2.82875400
116regulation of interferon-alpha production (GO:0032647)2.81019004
117plasma lipoprotein particle assembly (GO:0034377)2.80818839
118negative regulation of T cell mediated immunity (GO:0002710)2.79591898
119cellular amino acid biosynthetic process (GO:0008652)2.78951801
120leukocyte degranulation (GO:0043299)2.78919270
121positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78226788
122response to host immune response (GO:0052572)2.78095388
123response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78095388
124glycerophospholipid catabolic process (GO:0046475)2.77519186
125aspartate family amino acid catabolic process (GO:0009068)2.77490774
126drug metabolic process (GO:0017144)2.77152612
127type I interferon signaling pathway (GO:0060337)2.76788648
128cellular response to type I interferon (GO:0071357)2.76788648
129regulation of fibrinolysis (GO:0051917)2.76048913
130leukocyte aggregation (GO:0070486)2.75670737
131cholesterol efflux (GO:0033344)2.75245538
132response to type I interferon (GO:0034340)2.75079625
133negative regulation of cytokine production involved in immune response (GO:0002719)2.73720460
134acylglycerol homeostasis (GO:0055090)2.73708558
135triglyceride homeostasis (GO:0070328)2.73708558
136detection of biotic stimulus (GO:0009595)2.72976210
137plasma lipoprotein particle remodeling (GO:0034369)2.72688777
138protein-lipid complex remodeling (GO:0034368)2.72688777
139macromolecular complex remodeling (GO:0034367)2.72688777
140negative regulation of lymphocyte mediated immunity (GO:0002707)2.72217046
141drug catabolic process (GO:0042737)2.71760118
142bile acid and bile salt transport (GO:0015721)2.71573694
143folic acid-containing compound metabolic process (GO:0006760)2.70198511
144plasma lipoprotein particle clearance (GO:0034381)2.70085742
145histone H3-K36 demethylation (GO:0070544)2.69295265
146regulation of protein activation cascade (GO:2000257)2.69011470
147regulation of lipoprotein metabolic process (GO:0050746)2.68965960
148negative T cell selection (GO:0043383)2.68882923
149sulfur amino acid metabolic process (GO:0000096)2.68417616
150pentose metabolic process (GO:0019321)2.67914140
151L-methionine biosynthetic process (GO:0071265)2.66294403
152amino acid salvage (GO:0043102)2.66294403
153L-methionine salvage (GO:0071267)2.66294403
154macrophage activation (GO:0042116)2.65544972
155reverse cholesterol transport (GO:0043691)2.65428049
156positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65149016
157positive regulation of interferon-beta production (GO:0032728)2.65050340
158piRNA metabolic process (GO:0034587)2.64106265
159cytokine biosynthetic process (GO:0042089)2.62550804
160fatty-acyl-CoA biosynthetic process (GO:0046949)2.62144773
161protein-lipid complex assembly (GO:0065005)2.62127691
162disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.61779450
163killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.61779450
164iron coordination entity transport (GO:1901678)2.61625241
165positive regulation of B cell differentiation (GO:0045579)2.61228480
166positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60924937
167regulation of toll-like receptor signaling pathway (GO:0034121)2.60590062
168complement activation, alternative pathway (GO:0006957)2.60488469
169regulation of leukocyte degranulation (GO:0043300)2.60294819
170aspartate family amino acid metabolic process (GO:0009066)2.59857469
171positive regulation of antigen processing and presentation (GO:0002579)2.59757938
172regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.59678121
173positive regulation of Cdc42 GTPase activity (GO:0043089)2.59377987
174negative regulation of fatty acid biosynthetic process (GO:0045717)2.59111705
175sulfur amino acid biosynthetic process (GO:0000097)2.59013287
176regulation of mast cell activation involved in immune response (GO:0033006)2.58096711
177T-helper 1 type immune response (GO:0042088)2.58008784
178regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57825759
179cellular modified amino acid catabolic process (GO:0042219)2.57769323
180long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.57658303
181cofactor catabolic process (GO:0051187)2.57272548
182positive regulation of type 2 immune response (GO:0002830)2.56621060
183leukocyte migration involved in inflammatory response (GO:0002523)2.55434770
184cell wall macromolecule metabolic process (GO:0044036)2.55348352
185regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55010838
186oligosaccharide catabolic process (GO:0009313)2.53104168
187negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.52619667
188mast cell activation (GO:0045576)2.52465069
189positive T cell selection (GO:0043368)2.51392517
190negative regulation of leukocyte mediated immunity (GO:0002704)2.50540450
191neutrophil mediated immunity (GO:0002446)2.50006095
192regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.49783503
193response to host defenses (GO:0052200)2.49016128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.47996532
2E2F7_22180533_ChIP-Seq_HELA_Human4.04985707
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.94339842
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.72372369
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.68784689
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.62030464
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.51128129
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.38985917
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.99268535
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.97794098
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.95865731
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.91771613
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.90319670
14VDR_21846776_ChIP-Seq_THP-1_Human2.90295664
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.79767115
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.79767115
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.79767115
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62688412
19MYC_22102868_ChIP-Seq_BL_Human2.58228588
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.53973917
21AR_21909140_ChIP-Seq_LNCAP_Human2.47027584
22VDR_24763502_ChIP-Seq_THP-1_Human2.46865108
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42014799
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31148240
25* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28429925
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25485326
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22233043
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.22025976
29* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21841830
30SPI1_23547873_ChIP-Seq_NB4_Human2.17738708
31SCL_19346495_ChIP-Seq_HPC-7_Human2.17257469
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16233964
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13932380
34* MAF_26560356_Chip-Seq_TH1_Human2.09150076
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03182465
36MYC_18555785_ChIP-Seq_MESCs_Mouse2.01080140
37GATA1_22025678_ChIP-Seq_K562_Human1.99424647
38* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96774231
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96676118
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94969795
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94488287
42* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90229901
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90185331
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.89303341
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89204504
46* RUNX1_22412390_ChIP-Seq_EML_Mouse1.88622421
47* UTX_26944678_Chip-Seq_JUKART_Human1.88565724
48TCF7_22412390_ChIP-Seq_EML_Mouse1.87598534
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87271788
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83217115
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81139240
52* MYB_26560356_Chip-Seq_TH2_Human1.80818255
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79420927
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78879275
55* MYB_26560356_Chip-Seq_TH1_Human1.76169313
56SPI1_23127762_ChIP-Seq_K562_Human1.76142887
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75373365
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.75177961
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73132423
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73071277
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71278302
62* MAF_26560356_Chip-Seq_TH2_Human1.65566232
63* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62274744
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60571780
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60553724
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56477961
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56387724
68RUNX_20019798_ChIP-Seq_JUKART_Human1.55493850
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54791553
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.54783862
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53982771
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.53531643
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53188039
74* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52816406
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52806959
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49268464
77TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49006521
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48975104
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45608410
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44618971
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44181259
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42940029
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41998545
84* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41734979
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39506660
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39226811
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39077708
88BCOR_27268052_Chip-Seq_Bcells_Human1.38314500
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36475983
90GATA1_19941826_ChIP-Seq_K562_Human1.36114323
91TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35480381
92IRF1_19129219_ChIP-ChIP_H3396_Human1.34778809
93* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33923734
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33180120
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32968883
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32916258
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32782798
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32693488
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32505826
100LXR_22292898_ChIP-Seq_THP-1_Human1.32399413
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32010540
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31955760
103RACK7_27058665_Chip-Seq_MCF-7_Human1.30450954
104* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30412515
105* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29869841
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29824871
107GATA1_19941827_ChIP-Seq_MEL_Mouse1.27310420
108NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26745531
109ETS1_20019798_ChIP-Seq_JURKAT_Human1.25919022
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23633879
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23005575
112NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.22462156
113* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21745092
114* KDM2B_26808549_Chip-Seq_DND41_Human1.21056147
115* ELK3_25401928_ChIP-Seq_HUVEC_Human1.19065000
116KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19030583
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18720329
118GATA3_27048872_Chip-Seq_THYMUS_Human1.18691032
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18641170
120VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16839444
121KDM5A_27292631_Chip-Seq_BREAST_Human1.15874924
122NCOR1_26117541_ChIP-Seq_K562_Human1.15231451
123SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13252848
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13038148
125TFEB_21752829_ChIP-Seq_HELA_Human1.12840728
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.12346276
127CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11785428
128XRN2_22483619_ChIP-Seq_HELA_Human1.10501570
129BCL6_27268052_Chip-Seq_Bcells_Human1.10432690
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10004170
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09940238
132CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09311113
133SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09236261
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07937209
135* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07786088
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06609529
137DCP1A_22483619_ChIP-Seq_HELA_Human1.06531907
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05892072
139P68_20966046_ChIP-Seq_HELA_Human1.05890159
140PU_27001747_Chip-Seq_BMDM_Mouse1.05177902
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04154291
142* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03996689
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03823821
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03784439
145KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03635292
146* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02564583
147GATA3_26560356_Chip-Seq_TH2_Human1.02196305
148GATA2_19941826_ChIP-Seq_K562_Human0.98130625
149GATA4_25053715_ChIP-Seq_YYC3_Human0.96896611
150E2F1_20622854_ChIP-Seq_HELA_Human0.96602918
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95775316
152ZNF263_19887448_ChIP-Seq_K562_Human0.95326157
153ESR2_21235772_ChIP-Seq_MCF-7_Human0.93645030
154ESR1_20079471_ChIP-ChIP_T-47D_Human0.93404913
155VDR_23849224_ChIP-Seq_CD4+_Human0.92650865
156RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92247789
157ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91467749
158VDR_22108803_ChIP-Seq_LS180_Human0.91296767
159PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91200499
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90301811
161* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.89104041
162YY1_21170310_ChIP-Seq_MESCs_Mouse0.87628838
163GABP_19822575_ChIP-Seq_HepG2_Human0.87144428
164FOXP3_21729870_ChIP-Seq_TREG_Human0.87111411
165SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85550256
166STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85391775
167* KAP1_27257070_Chip-Seq_ESCs_Mouse0.84913022
168SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83530804
169RARB_24833708_ChIP-Seq_LIVER_Mouse0.83082045
170* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82786177
171TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81996359
172GATA1_26923725_Chip-Seq_HPCs_Mouse0.81710215
173POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81604620
174* SOX17_20123909_ChIP-Seq_XEN_Mouse0.81592283
175OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81562819
176GATA6_25053715_ChIP-Seq_YYC3_Human0.80389136
177SALL1_21062744_ChIP-ChIP_HESCs_Human0.76000667
178KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74606661
179* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.71959440
180* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71697035
181RARA_24833708_ChIP-Seq_LIVER_Mouse0.71495414
182* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71394212
183NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71024798
184* HNF4A_19822575_ChIP-Seq_HepG2_Human0.70247830
185FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.69923256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.07245745
2MP0003806_abnormal_nucleotide_metabolis5.51373680
3MP0002139_abnormal_hepatobiliary_system5.17921788
4MP0003303_peritoneal_inflammation4.26157963
5MP0005085_abnormal_gallbladder_physiolo3.87116042
6MP0005365_abnormal_bile_salt3.51237724
7MP0009840_abnormal_foam_cell3.37513897
8MP0008875_abnormal_xenobiotic_pharmacok3.36899321
9MP0005410_abnormal_fertilization3.22559832
10MP0003436_decreased_susceptibility_to3.06225215
11MP0003724_increased_susceptibility_to2.98406918
12MP0001835_abnormal_antigen_presentation2.73653465
13MP0005058_abnormal_lysosome_morphology2.65183224
14MP0005671_abnormal_response_to2.55666479
15MP0002419_abnormal_innate_immunity2.42756988
16MP0003252_abnormal_bile_duct2.40305457
17MP0000685_abnormal_immune_system2.38471712
18MP0005025_abnormal_response_to2.34365976
19MP0001800_abnormal_humoral_immune2.34354548
20MP0001666_abnormal_nutrient_absorption2.30166066
21MP0005332_abnormal_amino_acid2.24311792
22MP0005000_abnormal_immune_tolerance2.23501893
23MP0003718_maternal_effect2.20198293
24MP0001790_abnormal_immune_system2.17280967
25MP0005387_immune_system_phenotype2.17280967
26MP0002148_abnormal_hypersensitivity_rea2.15064639
27MP0002723_abnormal_immune_serum2.11804828
28MP0002452_abnormal_antigen_presenting2.08674700
29MP0010329_abnormal_lipoprotein_level2.07707077
30MP0005451_abnormal_body_composition2.06518869
31MP0005464_abnormal_platelet_physiology2.00402966
32MP0003763_abnormal_thymus_physiology1.99884237
33MP0009785_altered_susceptibility_to1.97925034
34MP0002420_abnormal_adaptive_immunity1.95831693
35MP0008057_abnormal_DNA_replication1.95828427
36MP0001819_abnormal_immune_cell1.95351641
37MP0003950_abnormal_plasma_membrane1.94617624
38MP0008260_abnormal_autophagy1.90749280
39MP0003693_abnormal_embryo_hatching1.89134920
40MP0003172_abnormal_lysosome_physiology1.86101427
41MP0004947_skin_inflammation1.83369569
42MP0004957_abnormal_blastocyst_morpholog1.80808089
43MP0002398_abnormal_bone_marrow1.72668947
44MP0010155_abnormal_intestine_physiology1.69086548
45MP0009333_abnormal_splenocyte_physiolog1.68223426
46MP0000920_abnormal_myelination1.66037489
47MP0004019_abnormal_vitamin_homeostasis1.64402306
48MP0000716_abnormal_immune_system1.61237728
49MP0003186_abnormal_redox_activity1.57997701
50MP0004264_abnormal_extraembryonic_tissu1.55682317
51MP0003136_yellow_coat_color1.54278377
52MP0001661_extended_life_span1.53575465
53MP0001533_abnormal_skeleton_physiology1.53251145
54MP0004381_abnormal_hair_follicle1.52900062
55MP0000609_abnormal_liver_physiology1.51944900
56MP0001929_abnormal_gametogenesis1.51791493
57MP0000689_abnormal_spleen_morphology1.49059714
58MP0002722_abnormal_immune_system1.48302519
59MP0001845_abnormal_inflammatory_respons1.48209044
60MP0003195_calcinosis1.47584439
61MP0002405_respiratory_system_inflammati1.47288405
62MP0003111_abnormal_nucleus_morphology1.47275873
63MP0005076_abnormal_cell_differentiation1.43334219
64MP0001986_abnormal_taste_sensitivity1.39128401
65MP0002118_abnormal_lipid_homeostasis1.38173133
66MP0002429_abnormal_blood_cell1.38097581
67MP0010094_abnormal_chromosome_stability1.36131854
68MP0008469_abnormal_protein_level1.35135412
69MP0002396_abnormal_hematopoietic_system1.32968557
70MP0003077_abnormal_cell_cycle1.32758633
71MP0001764_abnormal_homeostasis1.31064522
72MP0000462_abnormal_digestive_system1.30455619
73MP0005083_abnormal_biliary_tract1.27880164
74MP0009278_abnormal_bone_marrow1.26817317
75MP0003698_abnormal_male_reproductive1.26645426
76MP0003191_abnormal_cellular_cholesterol1.25738436
77MP0003828_pulmonary_edema1.25526443
78MP0002653_abnormal_ependyma_morphology1.24573241
79MP0003011_delayed_dark_adaptation1.23810546
80MP0005408_hypopigmentation1.23434267
81MP0004043_abnormal_pH_regulation1.19834851
82MP0005310_abnormal_salivary_gland1.19578628
83MP0000703_abnormal_thymus_morphology1.19053520
84MP0003183_abnormal_peptide_metabolism1.17299714
85MP0002166_altered_tumor_susceptibility1.16886582
86MP0001730_embryonic_growth_arrest1.16754549
87MP0002009_preneoplasia1.15056866
88MP0005319_abnormal_enzyme/_coenzyme1.14642525
89MP0003868_abnormal_feces_composition1.14314990
90MP0005397_hematopoietic_system_phenotyp1.11942961
91MP0001545_abnormal_hematopoietic_system1.11942961
92MP0005647_abnormal_sex_gland1.09806190
93MP0003300_gastrointestinal_ulcer1.08871437
94MP0001145_abnormal_male_reproductive1.08713039
95MP0002277_abnormal_respiratory_mucosa1.06113160
96MP0002998_abnormal_bone_remodeling1.04952695
97MP0005174_abnormal_tail_pigmentation1.04520712
98MP0009643_abnormal_urine_homeostasis1.03439035
99MP0000858_altered_metastatic_potential1.02646499
100MP0002254_reproductive_system_inflammat1.02399764
101MP0000015_abnormal_ear_pigmentation1.02299602
102MP0003656_abnormal_erythrocyte_physiolo1.01406033
103MP0009764_decreased_sensitivity_to0.99893571
104MP0002210_abnormal_sex_determination0.99351995
105MP0000653_abnormal_sex_gland0.98294464
106MP0003690_abnormal_glial_cell0.98167014
107MP0005584_abnormal_enzyme/coenzyme_acti0.97698591
108MP0010352_gastrointestinal_tract_polyps0.96978632
109MP0004147_increased_porphyrin_level0.96233565
110MP0010234_abnormal_vibrissa_follicle0.92932528
111MP0005395_other_phenotype0.89253759
112MP0002161_abnormal_fertility/fecundity0.88179017
113MP0008932_abnormal_embryonic_tissue0.87631742
114MP0005266_abnormal_metabolism0.87254613
115MP0001873_stomach_inflammation0.86715586
116MP0010678_abnormal_skin_adnexa0.86296447
117MP0003866_abnormal_defecation0.86178104
118MP0005075_abnormal_melanosome_morpholog0.85683726
119MP0000579_abnormal_nail_morphology0.84672118
120MP0009765_abnormal_xenobiotic_induced0.83246527
121MP0003453_abnormal_keratinocyte_physiol0.82625141
122MP0003646_muscle_fatigue0.80937400
123MP0004185_abnormal_adipocyte_glucose0.80624025
124MP0008004_abnormal_stomach_pH0.80604609
125MP0000598_abnormal_liver_morphology0.79651157
126MP0002006_tumorigenesis0.79552846
127MP0009697_abnormal_copulation0.78480850
128MP0002019_abnormal_tumor_incidence0.77506024
129MP0005666_abnormal_adipose_tissue0.77297000
130MP0005636_abnormal_mineral_homeostasis0.74796439
131MP0008058_abnormal_DNA_repair0.74713580
132MP0003890_abnormal_embryonic-extraembry0.74600088
133MP0001485_abnormal_pinna_reflex0.74008568
134MP0003448_altered_tumor_morphology0.73573715
135MP0001851_eye_inflammation0.73503715
136MP0000465_gastrointestinal_hemorrhage0.72299295
137MP0000490_abnormal_crypts_of0.72089284
138MP0002332_abnormal_exercise_endurance0.71872003
139MP0000350_abnormal_cell_proliferation0.71087424
140MP0005376_homeostasis/metabolism_phenot0.70087032
141MP0000377_abnormal_hair_follicle0.69804126
142MP0002796_impaired_skin_barrier0.69797888
143MP0004808_abnormal_hematopoietic_stem0.69795581
144MP0001672_abnormal_embryogenesis/_devel0.69008661
145MP0005380_embryogenesis_phenotype0.69008661
146MP0005023_abnormal_wound_healing0.68619489
147MP0003937_abnormal_limbs/digits/tail_de0.68142261
148MP0002132_abnormal_respiratory_system0.68130160
149MP0000604_amyloidosis0.67775435
150MP0003705_abnormal_hypodermis_morpholog0.66858852
151MP0005670_abnormal_white_adipose0.65209781
152MP0001663_abnormal_digestive_system0.64481747
153MP0001346_abnormal_lacrimal_gland0.63782868
154MP0009763_increased_sensitivity_to0.63649084
155MP0006082_CNS_inflammation0.63326524
156MP0004133_heterotaxia0.61858483
157MP0006072_abnormal_retinal_apoptosis0.61289939
158MP0002085_abnormal_embryonic_tissue0.61195639
159MP0010030_abnormal_orbit_morphology0.61154826
160MP0008877_abnormal_DNA_methylation0.59826297
161MP0008873_increased_physiological_sensi0.59579598
162MP0002092_abnormal_eye_morphology0.59287024
163MP0002138_abnormal_hepatobiliary_system0.59222264
164MP0001697_abnormal_embryo_size0.58833113
165MP0003699_abnormal_female_reproductive0.56239456
166MP0000383_abnormal_hair_follicle0.54699041
167MP0001293_anophthalmia0.54431327
168MP0003786_premature_aging0.54071433
169MP0004885_abnormal_endolymph0.53580291
170MP0000647_abnormal_sebaceous_gland0.53483633

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.64379288
2Hypobetalipoproteinemia (HP:0003563)5.10245472
3Abnormality of macrophages (HP:0004311)5.09539927
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.08723876
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.72047877
6Eczematoid dermatitis (HP:0000976)4.59675055
7Xanthomatosis (HP:0000991)4.52901870
8Recurrent bacterial skin infections (HP:0005406)4.38748882
9Recurrent abscess formation (HP:0002722)4.33506331
10Deep venous thrombosis (HP:0002625)4.20387146
11Abnormality of glycine metabolism (HP:0010895)4.05111899
12Abnormality of serine family amino acid metabolism (HP:0010894)4.05111899
13Hyperglycinuria (HP:0003108)4.00042794
14Vacuolated lymphocytes (HP:0001922)3.79349524
15Abnormality of sulfur amino acid metabolism (HP:0004339)3.61829623
16Hyperglycinemia (HP:0002154)3.57917781
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.55404435
18Hypolipoproteinemia (HP:0010981)3.53078275
19Prolonged partial thromboplastin time (HP:0003645)3.39842789
20Myositis (HP:0100614)3.36842088
21Fat malabsorption (HP:0002630)3.34756810
22Abnormality of methionine metabolism (HP:0010901)3.33662355
23Hyperlipoproteinemia (HP:0010980)3.33255811
24Hyperammonemia (HP:0001987)3.26215053
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.23775900
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.21283705
27Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.21283705
28Retrobulbar optic neuritis (HP:0100654)3.21103268
29Optic neuritis (HP:0100653)3.21103268
30Stomatitis (HP:0010280)3.18427372
31Abnormality of pyrimidine metabolism (HP:0004353)3.17391817
32Orchitis (HP:0100796)3.16265583
33Agammaglobulinemia (HP:0004432)3.15095554
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.13427035
35Recurrent gram-negative bacterial infections (HP:0005420)3.11743650
36Meningitis (HP:0001287)3.09230784
37Progressive external ophthalmoplegia (HP:0000590)3.07694938
38Abnormality of glutamine family amino acid metabolism (HP:0010902)3.02594655
39Gastrointestinal infarctions (HP:0005244)3.00874218
40Obstructive lung disease (HP:0006536)2.99890490
41Chronic obstructive pulmonary disease (HP:0006510)2.99890490
42Prostate neoplasm (HP:0100787)2.95958165
43Cellulitis (HP:0100658)2.89253229
44Gingival bleeding (HP:0000225)2.86269013
45Parakeratosis (HP:0001036)2.85717714
46Dysostosis multiplex (HP:0000943)2.83495093
47Vascular calcification (HP:0004934)2.79586136
48Recurrent fungal infections (HP:0002841)2.78295836
49Malnutrition (HP:0004395)2.75356907
50Increased cerebral lipofuscin (HP:0011813)2.74138643
51Impulsivity (HP:0100710)2.73212803
52Ileus (HP:0002595)2.71611860
53Recurrent skin infections (HP:0001581)2.70920731
54Vasculitis (HP:0002633)2.68515429
55Mediastinal lymphadenopathy (HP:0100721)2.67951547
56Breast hypoplasia (HP:0003187)2.64643982
57Persistence of primary teeth (HP:0006335)2.62236278
58Prolonged bleeding time (HP:0003010)2.62011280
59Epistaxis (HP:0000421)2.61938752
60Epidermoid cyst (HP:0200040)2.60200711
61Petechiae (HP:0000967)2.58469637
62Hypoalphalipoproteinemia (HP:0003233)2.57735337
63Osteomyelitis (HP:0002754)2.57085866
64Spontaneous hematomas (HP:0007420)2.55779570
65Conjugated hyperbilirubinemia (HP:0002908)2.55699116
66Loss of speech (HP:0002371)2.55551480
67Increased serum ferritin (HP:0003281)2.52511477
68Nausea (HP:0002018)2.52168438
69Slow saccadic eye movements (HP:0000514)2.51358352
70Steatorrhea (HP:0002570)2.50409059
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.50337406
72Gastrointestinal stroma tumor (HP:0100723)2.48809943
73Increased IgE level (HP:0003212)2.48734287
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.47368641
75Autoimmune thrombocytopenia (HP:0001973)2.47227886
76Abnormality of the corticospinal tract (HP:0002492)2.43803556
77Anorexia (HP:0002039)2.43559228
78Cerebral hypomyelination (HP:0006808)2.41823560
79Colitis (HP:0002583)2.41666316
80Spastic paraparesis (HP:0002313)2.40657026
81Recurrent viral infections (HP:0004429)2.40617579
82Gastrointestinal inflammation (HP:0004386)2.40425532
83Inflammation of the large intestine (HP:0002037)2.39934207
84Increased serum pyruvate (HP:0003542)2.37246457
85Abnormality of glycolysis (HP:0004366)2.37246457
86Encephalitis (HP:0002383)2.36271482
87Urticaria (HP:0001025)2.35880055
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35608655
89Thrombocytosis (HP:0001894)2.34831021
90Cardiovascular calcification (HP:0011915)2.34798473
91Complement deficiency (HP:0004431)2.34042568
92Hypercholesterolemia (HP:0003124)2.33639147
93T lymphocytopenia (HP:0005403)2.33536089
94Abnormality of the prostate (HP:0008775)2.32202721
95Neurofibrillary tangles (HP:0002185)2.29679608
96Acanthocytosis (HP:0001927)2.29054318
97Peripheral hypomyelination (HP:0007182)2.26745149
98Abnormality of the common coagulation pathway (HP:0010990)2.26238312
99Abnormality of T cell number (HP:0011839)2.25316176
100Keratoconjunctivitis sicca (HP:0001097)2.23943028
101Elevated erythrocyte sedimentation rate (HP:0003565)2.23485331
102Pustule (HP:0200039)2.22431838
103Hypochromic anemia (HP:0001931)2.22189722
104Abnormality of serum amino acid levels (HP:0003112)2.21673767
105Lethargy (HP:0001254)2.21256131
106Poikilocytosis (HP:0004447)2.21047634
107Asymmetric septal hypertrophy (HP:0001670)2.20419266
108Abnormality of iron homeostasis (HP:0011031)2.20148900
109Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19867139
110Amyloidosis (HP:0011034)2.18831142
111Premature loss of primary teeth (HP:0006323)2.18829331
112Ketosis (HP:0001946)2.18582846
113Hypochromic microcytic anemia (HP:0004840)2.15672218
114Abnormality of nucleobase metabolism (HP:0010932)2.14803277
115Congenital ichthyosiform erythroderma (HP:0007431)2.12780228
116Gingivitis (HP:0000230)2.12054844
117Irritability (HP:0000737)2.09207716
118Arterial thrombosis (HP:0004420)2.08413142
119Autoimmune hemolytic anemia (HP:0001890)2.06724970
120Spastic tetraparesis (HP:0001285)2.05808408
121Abnormality of glycolipid metabolism (HP:0010969)2.04751254
122Abnormality of liposaccharide metabolism (HP:0010968)2.04751254
123Abnormality of glycosphingolipid metabolism (HP:0004343)2.04751254
124Recurrent cutaneous fungal infections (HP:0011370)2.04025373
125Chronic mucocutaneous candidiasis (HP:0002728)2.04025373
126Abnormality of polysaccharide metabolism (HP:0011012)2.02950952
127Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02950952
128Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02950952
129Abnormality of fatty-acid metabolism (HP:0004359)2.02745116
130Papilloma (HP:0012740)2.02558356
131Verrucae (HP:0200043)2.02558356
132Purpura (HP:0000979)2.02015810
133Hyperbilirubinemia (HP:0002904)2.01928434
134Spontaneous abortion (HP:0005268)2.01569426
135Sepsis (HP:0100806)2.00587929
136Polyneuropathy (HP:0001271)2.00472416
137Megaloblastic anemia (HP:0001889)2.00370019
138Recurrent pneumonia (HP:0006532)1.98502310
139Skin rash (HP:0000988)1.98062244
140Absent/shortened dynein arms (HP:0200106)1.97648946
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.97648946
142Absent radius (HP:0003974)1.96975981
143Abnormality of the fingertips (HP:0001211)1.96353047
144Gangrene (HP:0100758)1.95964651
145Pulmonary infiltrates (HP:0002113)1.95936969
146Amniotic constriction ring (HP:0009775)1.95203670
147Abnormality of placental membranes (HP:0011409)1.95203670
148Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94829010
149Abnormality of T cells (HP:0002843)1.94705414
150Morphological abnormality of the inner ear (HP:0011390)1.94695409
151Abnormality of cochlea (HP:0000375)1.93957843
152IgM deficiency (HP:0002850)1.93353561
153Abnormality of vitamin metabolism (HP:0100508)1.93196072
154Abnormality of the intrinsic pathway (HP:0010989)1.93142991
155Leukocytosis (HP:0001974)1.92593161
156Chest pain (HP:0100749)1.91552897
157Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91044783
158Recurrent bronchitis (HP:0002837)1.90894243
159Prolonged neonatal jaundice (HP:0006579)1.90865374
160Keratoconjunctivitis (HP:0001096)1.89047625
161Chronic bronchitis (HP:0004469)1.88461315
162Pulmonary embolism (HP:0002204)1.87465004
163Periodontitis (HP:0000704)1.86380999
164Aplasia involving forearm bones (HP:0009822)1.85557718
165Absent forearm bone (HP:0003953)1.85557718
166CNS hypomyelination (HP:0003429)1.84638128
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84069350
168Dicarboxylic aciduria (HP:0003215)1.84069350
169Spastic diplegia (HP:0001264)1.81435023
170Esophageal atresia (HP:0002032)1.81432887
171Abnormal enzyme/coenzyme activity (HP:0012379)1.79536714
172Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79428373
173Carpal bone hypoplasia (HP:0001498)1.78765956
174Hepatosplenomegaly (HP:0001433)1.77727794
175Abnormality of complement system (HP:0005339)1.77646352
176Rickets (HP:0002748)1.77200882
177Abnormality of transition element cation homeostasis (HP:0011030)1.73322324
178Hypoglycemic coma (HP:0001325)1.72957163
179Brushfield spots (HP:0001088)1.71514846
180Abnormality of alkaline phosphatase activity (HP:0004379)1.68443146
181Autoamputation (HP:0001218)1.67726248
182Vertebral clefting (HP:0008428)1.66459929
183Seborrheic dermatitis (HP:0001051)1.66062240
184Clitoromegaly (HP:0000057)1.65492020
185Aplasia/hypoplasia of the humerus (HP:0006507)1.64443646
186Adrenal hypoplasia (HP:0000835)1.63919360
187Abnormality of purine metabolism (HP:0004352)1.63509007
188Sensory axonal neuropathy (HP:0003390)1.62646624
189Joint hemorrhage (HP:0005261)1.61317729
190Peripheral demyelination (HP:0011096)1.60342693
191Cerebral edema (HP:0002181)1.60150539
192Paraparesis (HP:0002385)1.60090068
193Birth length less than 3rd percentile (HP:0003561)1.59877474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.01764573
2BUB13.90706162
3RIPK43.74938111
4WEE12.96752275
5MAP4K12.95242084
6OXSR12.88027104
7MAP2K32.64588769
8BCKDK2.60182102
9EPHB12.43824475
10PBK2.41139383
11MAP3K132.38357997
12ICK2.37554887
13IRAK42.36216102
14STK102.20040146
15TESK12.19538334
16PRPF4B2.18368653
17TTK2.13227270
18LATS12.06020131
19MST42.00651373
20AKT32.00097534
21MAP3K141.98475743
22EPHA21.96311630
23TBK11.89125900
24MET1.89073980
25CDK121.88701410
26NEK21.86971853
27CDC71.79921671
28TNK21.79028561
29TRIB31.75365783
30PNCK1.71767477
31IKBKE1.67089672
32MAP2K21.59247680
33EIF2AK31.57351928
34EIF2AK11.56840869
35BRSK21.52663570
36ZAP701.52133053
37PDK41.51090961
38PDK31.51090961
39IRAK31.44790479
40SMG11.44120974
41TAOK11.41201933
42SIK31.40529486
43ERN11.33970957
44GRK61.32856183
45MARK31.32802422
46MAP3K111.31276849
47SIK11.29566810
48MAP3K81.29299313
49MUSK1.27224916
50IKBKB1.26864087
51KSR21.23366705
52WNK41.23138499
53MAP3K11.22451911
54CHEK21.22426781
55SYK1.21938801
56MAPKAPK51.20805200
57PDK21.17989656
58PRKD31.16676287
59PDPK11.14967118
60MATK1.14764305
61JAK31.11807151
62TAOK21.11094340
63PLK11.08862264
64PDK11.07053025
65ERBB41.06701292
66HCK1.06523906
67MAPKAPK31.03671176
68CDK71.02090654
69DYRK31.01396059
70BCR0.98784610
71BTK0.97933669
72AURKB0.97164690
73IRAK20.96126065
74STK30.96011112
75ARAF0.93814462
76VRK10.93115317
77RAF10.92952604
78MELK0.92139787
79TLK10.91807563
80MAPK150.91666251
81LYN0.91572321
82PLK40.90725470
83DDR20.89273764
84BRD40.88737000
85TXK0.88249281
86AURKA0.87574981
87FES0.86686430
88PIM10.85245163
89CAMK1D0.84977025
90CSNK1G10.83555394
91EEF2K0.81280080
92JAK20.80372492
93PAK10.79480556
94ITK0.78690393
95CHEK10.78398421
96JAK10.76762273
97FGR0.76622284
98FGFR20.76541419
99CSNK1G30.75139091
100CDK190.74975321
101LIMK10.74962702
102ACVR1B0.74537016
103TAOK30.72645761
104YES10.72521699
105WNK10.71325020
106RIPK10.70596295
107LCK0.70424771
108STK40.68280090
109FGFR40.68139564
110MARK20.67592434
111PKN10.67533724
112FRK0.67387252
113CSK0.67324947
114MAP3K30.66594100
115MAPK120.62231807
116IRAK10.61665151
117CDC42BPA0.61319956
118BMPR20.60814596
119PIK3CG0.60203094
120NEK60.59615480
121DYRK1B0.59483851
122MAPK70.58595227
123GSK3A0.58287361
124BMX0.57709220
125STK160.57040541
126KIT0.55106106
127SRPK10.54430127
128RPS6KA50.54271279
129CSNK1A1L0.54131627
130MAPK110.53761509
131MTOR0.52559217
132CDK40.51241289
133MAP3K20.51237450
134ZAK0.50425517
135BRAF0.47238758
136CHUK0.47029030
137MAP3K100.46714808
138MAP2K60.45967821
139CLK10.45941490
140BLK0.45626393
141ATR0.44622093
142TEC0.44565413
143CDK20.43945140
144CSF1R0.43538003
145RPS6KL10.43226205
146RPS6KC10.43226205
147PLK30.43044631
148CSNK2A20.42851145
149MAPK40.41613869
150PAK40.41504975
151CDK60.41337372
152SIK20.41184688
153LRRK20.41076055
154FGFR30.40551728
155ATM0.40539553
156DYRK20.39746826
157PKN20.39727278
158NLK0.38022758
159NUAK10.36915895
160TYK20.36769730
161CSNK1D0.36621441
162BRSK10.36247950
163GRK10.36126930
164MOS0.35568301
165ERBB20.33944787
166PRKCI0.33594888
167RPS6KB20.33546193
168ABL20.33484679
169TYRO30.33389179
170CSNK2A10.31449839

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.34465450
2Nitrogen metabolism_Homo sapiens_hsa009102.90220460
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.87896294
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.74264441
5Osteoclast differentiation_Homo sapiens_hsa043802.69611012
6B cell receptor signaling pathway_Homo sapiens_hsa046622.67340343
7Leishmaniasis_Homo sapiens_hsa051402.56077165
8Vitamin B6 metabolism_Homo sapiens_hsa007502.52378519
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42293237
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33607039
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30207301
12Steroid biosynthesis_Homo sapiens_hsa001002.27634818
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.13836442
14Primary immunodeficiency_Homo sapiens_hsa053402.13504641
15Histidine metabolism_Homo sapiens_hsa003402.12745269
16Acute myeloid leukemia_Homo sapiens_hsa052212.07416394
17Toll-like receptor signaling pathway_Homo sapiens_hsa046202.03904838
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01196992
19Fatty acid elongation_Homo sapiens_hsa000621.99060995
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98484164
21Folate biosynthesis_Homo sapiens_hsa007901.96197374
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96103232
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95852927
24Allograft rejection_Homo sapiens_hsa053301.94448255
25Sulfur metabolism_Homo sapiens_hsa009201.91403631
26Arginine biosynthesis_Homo sapiens_hsa002201.88534541
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84305111
28Tuberculosis_Homo sapiens_hsa051521.83841494
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80104307
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79816703
31Graft-versus-host disease_Homo sapiens_hsa053321.79796821
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75078032
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.74777933
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73295915
35Tryptophan metabolism_Homo sapiens_hsa003801.72680665
36Autoimmune thyroid disease_Homo sapiens_hsa053201.72181053
37Influenza A_Homo sapiens_hsa051641.69248337
38Measles_Homo sapiens_hsa051621.66058225
39Selenocompound metabolism_Homo sapiens_hsa004501.65558751
40Fatty acid degradation_Homo sapiens_hsa000711.64770207
41Legionellosis_Homo sapiens_hsa051341.64341608
42Glutathione metabolism_Homo sapiens_hsa004801.64140126
43Herpes simplex infection_Homo sapiens_hsa051681.60759388
44Peroxisome_Homo sapiens_hsa041461.60550930
45Butanoate metabolism_Homo sapiens_hsa006501.59911406
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58568234
47Chemical carcinogenesis_Homo sapiens_hsa052041.58088242
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.57231399
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57192273
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55993034
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.55990668
52Fat digestion and absorption_Homo sapiens_hsa049751.55141857
53Vitamin digestion and absorption_Homo sapiens_hsa049771.52075368
54Hepatitis C_Homo sapiens_hsa051601.51904060
55Lysosome_Homo sapiens_hsa041421.51327600
56Propanoate metabolism_Homo sapiens_hsa006401.50403584
57Hematopoietic cell lineage_Homo sapiens_hsa046401.48464494
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.48291153
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48169940
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46955511
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46621831
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46275296
63Antigen processing and presentation_Homo sapiens_hsa046121.44753583
64One carbon pool by folate_Homo sapiens_hsa006701.42426125
65T cell receptor signaling pathway_Homo sapiens_hsa046601.42290088
66Glycosaminoglycan degradation_Homo sapiens_hsa005311.41768558
67Arginine and proline metabolism_Homo sapiens_hsa003301.40111412
68Steroid hormone biosynthesis_Homo sapiens_hsa001401.38776519
69Retinol metabolism_Homo sapiens_hsa008301.37971016
70Linoleic acid metabolism_Homo sapiens_hsa005911.37963321
71Complement and coagulation cascades_Homo sapiens_hsa046101.37641906
72Pyruvate metabolism_Homo sapiens_hsa006201.36477569
73Fatty acid metabolism_Homo sapiens_hsa012121.35611069
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34247162
75Biosynthesis of amino acids_Homo sapiens_hsa012301.32678908
76Chemokine signaling pathway_Homo sapiens_hsa040621.27155213
77Toxoplasmosis_Homo sapiens_hsa051451.24096836
78PPAR signaling pathway_Homo sapiens_hsa033201.23823789
79Pentose phosphate pathway_Homo sapiens_hsa000301.23385983
80Malaria_Homo sapiens_hsa051441.20301776
81Asthma_Homo sapiens_hsa053101.19661717
82Non-small cell lung cancer_Homo sapiens_hsa052231.18190414
83TNF signaling pathway_Homo sapiens_hsa046681.17769392
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16839664
85beta-Alanine metabolism_Homo sapiens_hsa004101.10287541
86Hepatitis B_Homo sapiens_hsa051611.09716220
87Jak-STAT signaling pathway_Homo sapiens_hsa046301.09157838
88Galactose metabolism_Homo sapiens_hsa000521.06019588
89Carbon metabolism_Homo sapiens_hsa012001.05207840
90Ether lipid metabolism_Homo sapiens_hsa005651.04495731
91Mismatch repair_Homo sapiens_hsa034301.03819147
92Caffeine metabolism_Homo sapiens_hsa002321.03631824
93Type I diabetes mellitus_Homo sapiens_hsa049401.01988060
94RNA polymerase_Homo sapiens_hsa030201.01173847
95VEGF signaling pathway_Homo sapiens_hsa043700.99598409
96Platelet activation_Homo sapiens_hsa046110.98006468
97Apoptosis_Homo sapiens_hsa042100.97134269
98African trypanosomiasis_Homo sapiens_hsa051430.92487259
99Epstein-Barr virus infection_Homo sapiens_hsa051690.89955654
100Chronic myeloid leukemia_Homo sapiens_hsa052200.88550821
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88029105
102Glycerolipid metabolism_Homo sapiens_hsa005610.87427191
103DNA replication_Homo sapiens_hsa030300.87041204
104Viral carcinogenesis_Homo sapiens_hsa052030.86649719
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86086333
106Bile secretion_Homo sapiens_hsa049760.83609622
107Tyrosine metabolism_Homo sapiens_hsa003500.83450198
108Fructose and mannose metabolism_Homo sapiens_hsa000510.83241391
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81613007
110Rheumatoid arthritis_Homo sapiens_hsa053230.81077113
111Renin-angiotensin system_Homo sapiens_hsa046140.80709962
112Starch and sucrose metabolism_Homo sapiens_hsa005000.80609857
113Inositol phosphate metabolism_Homo sapiens_hsa005620.80554237
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.79325807
115ABC transporters_Homo sapiens_hsa020100.77569242
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.76626798
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75643375
118Metabolic pathways_Homo sapiens_hsa011000.75562681
119Insulin resistance_Homo sapiens_hsa049310.74132961
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73924700
121Pyrimidine metabolism_Homo sapiens_hsa002400.71528910
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70990273
123Protein export_Homo sapiens_hsa030600.70375132
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.70181106
125Pancreatic cancer_Homo sapiens_hsa052120.70143592
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69557312
127Basal transcription factors_Homo sapiens_hsa030220.69496066
128Viral myocarditis_Homo sapiens_hsa054160.69310279
129Staphylococcus aureus infection_Homo sapiens_hsa051500.69128357
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68978020
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.68925814
132Phenylalanine metabolism_Homo sapiens_hsa003600.68304067
133RNA transport_Homo sapiens_hsa030130.67739847
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67737217
135Proteasome_Homo sapiens_hsa030500.66972043
136Arachidonic acid metabolism_Homo sapiens_hsa005900.66285021
137Non-homologous end-joining_Homo sapiens_hsa034500.64440502
138Fatty acid biosynthesis_Homo sapiens_hsa000610.63579311
139Pertussis_Homo sapiens_hsa051330.63409817
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62686799
141Endometrial cancer_Homo sapiens_hsa052130.62569282
142Prolactin signaling pathway_Homo sapiens_hsa049170.61204401
143FoxO signaling pathway_Homo sapiens_hsa040680.60357833
144Sulfur relay system_Homo sapiens_hsa041220.59693067
145Homologous recombination_Homo sapiens_hsa034400.59584388
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59166298
147Renal cell carcinoma_Homo sapiens_hsa052110.58814626
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58762831
149HTLV-I infection_Homo sapiens_hsa051660.58688424
150HIF-1 signaling pathway_Homo sapiens_hsa040660.56779611
151Prostate cancer_Homo sapiens_hsa052150.55950205
152mTOR signaling pathway_Homo sapiens_hsa041500.55450744
153Endocytosis_Homo sapiens_hsa041440.55420355
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54079010
155Mineral absorption_Homo sapiens_hsa049780.52496498
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52375875
157Nucleotide excision repair_Homo sapiens_hsa034200.50274716
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49859748
159Lysine degradation_Homo sapiens_hsa003100.49144426
160Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48857908
161Fanconi anemia pathway_Homo sapiens_hsa034600.48289557
162Thyroid cancer_Homo sapiens_hsa052160.47009356
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45971590
164Cell cycle_Homo sapiens_hsa041100.44627246
165Phagosome_Homo sapiens_hsa041450.44014852
166Neurotrophin signaling pathway_Homo sapiens_hsa047220.43563728
167Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42812529
168Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42391185
169Insulin signaling pathway_Homo sapiens_hsa049100.42163898
170Base excision repair_Homo sapiens_hsa034100.40656835
171Spliceosome_Homo sapiens_hsa030400.40502679
172Shigellosis_Homo sapiens_hsa051310.40270638
173Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39648790
174Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39465721
175Sphingolipid signaling pathway_Homo sapiens_hsa040710.37655318
176Ribosome_Homo sapiens_hsa030100.37466395
177Sphingolipid metabolism_Homo sapiens_hsa006000.36346259
178Notch signaling pathway_Homo sapiens_hsa043300.35769469
179Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32975209
180Choline metabolism in cancer_Homo sapiens_hsa052310.32875166
181Systemic lupus erythematosus_Homo sapiens_hsa053220.32731672
182Purine metabolism_Homo sapiens_hsa002300.31851649

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