TET1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)5.72389118
2regulation of posttranscriptional gene silencing (GO:0060147)5.72389118
3regulation of gene silencing by miRNA (GO:0060964)5.72389118
4nuclear pore organization (GO:0006999)5.55127825
5nuclear pore complex assembly (GO:0051292)5.31020439
6regulation of helicase activity (GO:0051095)5.14644684
7DNA replication-dependent nucleosome organization (GO:0034723)4.72015037
8DNA replication-dependent nucleosome assembly (GO:0006335)4.72015037
9somatic diversification of immune receptors via somatic mutation (GO:0002566)4.46589129
10somatic hypermutation of immunoglobulin genes (GO:0016446)4.46589129
11regulation of histone H3-K9 methylation (GO:0051570)4.45384254
12negative regulation of histone methylation (GO:0031061)4.38780849
13IMP biosynthetic process (GO:0006188)4.33861854
14pre-miRNA processing (GO:0031054)4.12658308
15DNA unwinding involved in DNA replication (GO:0006268)4.10050043
16DNA replication initiation (GO:0006270)4.09576126
17pore complex assembly (GO:0046931)4.05161047
18mitotic metaphase plate congression (GO:0007080)4.02839138
19determination of adult lifespan (GO:0008340)3.96059745
20nucleobase biosynthetic process (GO:0046112)3.95444665
21protein K6-linked ubiquitination (GO:0085020)3.94443510
22mitotic nuclear envelope disassembly (GO:0007077)3.92615954
23protein localization to kinetochore (GO:0034501)3.86356078
24paraxial mesoderm development (GO:0048339)3.70121924
25purine nucleobase biosynthetic process (GO:0009113)3.69271823
26IMP metabolic process (GO:0046040)3.69152143
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.67865954
28metaphase plate congression (GO:0051310)3.67520874
29membrane disassembly (GO:0030397)3.66281232
30nuclear envelope disassembly (GO:0051081)3.66281232
31histone H4-K12 acetylation (GO:0043983)3.64253618
32kinetochore organization (GO:0051383)3.63338070
33folic acid-containing compound biosynthetic process (GO:0009396)3.61982971
34chromatin remodeling at centromere (GO:0031055)3.58017995
35DNA geometric change (GO:0032392)3.56692789
36DNA duplex unwinding (GO:0032508)3.56008933
37anterior/posterior axis specification, embryo (GO:0008595)3.53717224
38regulation of telomere maintenance via telomerase (GO:0032210)3.51374891
39mitotic sister chromatid cohesion (GO:0007064)3.51047305
40positive regulation of chromosome segregation (GO:0051984)3.49040892
41ribosome assembly (GO:0042255)3.48646795
42DNA strand elongation involved in DNA replication (GO:0006271)3.46989737
43negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.46343184
44negative regulation of translation, ncRNA-mediated (GO:0040033)3.46343184
45regulation of translation, ncRNA-mediated (GO:0045974)3.46343184
46DNA double-strand break processing (GO:0000729)3.38104630
47intra-S DNA damage checkpoint (GO:0031573)3.37092518
48kinetochore assembly (GO:0051382)3.36950194
49DNA replication-independent nucleosome organization (GO:0034724)3.34674812
50DNA replication-independent nucleosome assembly (GO:0006336)3.34674812
51CENP-A containing nucleosome assembly (GO:0034080)3.33851058
52DNA replication checkpoint (GO:0000076)3.33587561
53mismatch repair (GO:0006298)3.32973534
54mitotic sister chromatid segregation (GO:0000070)3.32519701
55regulation of centriole replication (GO:0046599)3.31923201
56DNA strand elongation (GO:0022616)3.31245308
57heterochromatin organization (GO:0070828)3.30607377
58negative regulation of chromosome segregation (GO:0051985)3.29665191
59regulation of spindle organization (GO:0090224)3.29625732
60regulation of centrosome cycle (GO:0046605)3.25671483
61histone H2A monoubiquitination (GO:0035518)3.22908485
62spindle checkpoint (GO:0031577)3.22720099
63* regulation of gene silencing (GO:0060968)3.22674879
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22628640
65regulation of mitotic spindle organization (GO:0060236)3.21518735
66negative regulation of mitotic sister chromatid separation (GO:2000816)3.21056057
67negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21056057
68negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21056057
69negative regulation of sister chromatid segregation (GO:0033046)3.21056057
70negative regulation of DNA recombination (GO:0045910)3.19057416
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18671908
72spindle assembly checkpoint (GO:0071173)3.18254472
73presynaptic membrane assembly (GO:0097105)3.18029921
74ribosome biogenesis (GO:0042254)3.17988830
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16366210
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16366210
77positive regulation of mitotic sister chromatid separation (GO:1901970)3.16366210
78protein localization to chromosome, centromeric region (GO:0071459)3.15526553
79sister chromatid segregation (GO:0000819)3.15138371
80establishment of integrated proviral latency (GO:0075713)3.14796994
81mitotic spindle checkpoint (GO:0071174)3.14714129
82telomere maintenance via semi-conservative replication (GO:0032201)3.13937668
83L-serine metabolic process (GO:0006563)3.13022435
84regulation of sister chromatid segregation (GO:0033045)3.12154212
85regulation of mitotic sister chromatid separation (GO:0010965)3.12154212
86regulation of mitotic sister chromatid segregation (GO:0033047)3.12154212
87mitotic spindle assembly checkpoint (GO:0007094)3.11903680
88negative regulation of DNA-dependent DNA replication (GO:2000104)3.11461374
89establishment of chromosome localization (GO:0051303)3.11237189
90regulation of chromosome segregation (GO:0051983)3.10785111
91histone exchange (GO:0043486)3.10740311
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10657100
93negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10613831
94chromatin assembly (GO:0031497)3.09961627
95attachment of spindle microtubules to kinetochore (GO:0008608)3.09212481
96negative regulation of DNA repair (GO:0045738)3.09199941
97formation of translation preinitiation complex (GO:0001731)3.06392088
98positive regulation of SMAD protein import into nucleus (GO:0060391)3.05043958
99regulation of translational fidelity (GO:0006450)3.02617112
100regulation of RNA export from nucleus (GO:0046831)3.02291049
101replication fork processing (GO:0031297)3.00880747
102chromatin assembly or disassembly (GO:0006333)3.00870155
103mitotic chromosome condensation (GO:0007076)3.00696958
104maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99155450
105negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.98008429
106negative regulation of histone modification (GO:0031057)2.94529021
107mitotic recombination (GO:0006312)2.93986396
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92477259
109regulation of mitotic spindle checkpoint (GO:1903504)2.92477259
110regulation of centrosome duplication (GO:0010824)2.91005854
111DNA damage response, detection of DNA damage (GO:0042769)2.87674206
112presynaptic membrane organization (GO:0097090)2.84126811
113ATP-dependent chromatin remodeling (GO:0043044)2.83512540
114double-strand break repair via nonhomologous end joining (GO:0006303)2.74126821
115non-recombinational repair (GO:0000726)2.74126821
116DNA ligation (GO:0006266)2.73223899
117ncRNA catabolic process (GO:0034661)2.72440851
118resolution of meiotic recombination intermediates (GO:0000712)2.71973325
119dorsal/ventral axis specification (GO:0009950)2.69555472
120mitotic G2/M transition checkpoint (GO:0044818)2.61093001
121DNA topological change (GO:0006265)2.60368054
122microtubule depolymerization (GO:0007019)2.56711726
123regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.55329358
124somite development (GO:0061053)2.54578148
125pyrimidine nucleobase catabolic process (GO:0006208)2.52465406
126DNA strand renaturation (GO:0000733)2.52365574
127lung-associated mesenchyme development (GO:0060484)2.48073870
128regulation of DNA endoreduplication (GO:0032875)2.47801017
129negative regulation of mitosis (GO:0045839)2.42631279
130regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40249648
131limb bud formation (GO:0060174)2.37286041
132otic vesicle formation (GO:0030916)2.33688802
133postreplication repair (GO:0006301)2.28874034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.42153121
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.10760659
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75398977
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.66504718
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.43889280
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.43889280
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.43889280
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.31294464
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.25899624
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00254267
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.86917570
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.84420205
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74899472
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61061074
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.60487130
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.52837969
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51922431
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.41404272
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.36801895
20SOX2_18555785_ChIP-Seq_MESCs_Mouse2.36248056
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33114179
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30995799
23ZNF274_21170338_ChIP-Seq_K562_Hela2.26768586
24POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.25349380
25FUS_26573619_Chip-Seq_HEK293_Human2.21955922
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20890564
27TCF3_18692474_ChIP-Seq_MEFs_Mouse2.18037507
28EWS_26573619_Chip-Seq_HEK293_Human2.14594237
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14411879
30TCF3_18692474_ChIP-Seq_MESCs_Mouse2.13570610
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.12655617
32MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09373162
33IGF1R_20145208_ChIP-Seq_DFB_Human2.08930518
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07759387
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.05588157
36GBX2_23144817_ChIP-Seq_PC3_Human1.99502306
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.98958380
38TAF15_26573619_Chip-Seq_HEK293_Human1.92497300
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92207416
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.91304244
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90413152
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86328250
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.85276644
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82834272
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81860725
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.81596314
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77400501
48NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76959921
49P300_19829295_ChIP-Seq_ESCs_Human1.74038193
50VDR_22108803_ChIP-Seq_LS180_Human1.73701524
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72987987
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72246544
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70565045
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69523773
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.66302870
56* XRN2_22483619_ChIP-Seq_HELA_Human1.63628656
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63013416
58AR_21909140_ChIP-Seq_LNCAP_Human1.61382239
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61002911
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60547554
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60020168
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59875303
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.56951858
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53351652
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49831527
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49563520
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49436265
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49265360
69EZH2_22144423_ChIP-Seq_EOC_Human1.49097860
70NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48664981
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47386759
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47114102
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46422467
74* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45122827
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43826359
76SOX2_18692474_ChIP-Seq_MESCs_Mouse1.42213191
77VDR_23849224_ChIP-Seq_CD4+_Human1.41121463
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.40710233
79IRF1_19129219_ChIP-ChIP_H3396_Human1.40500288
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40335983
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.40008408
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39835172
83MYC_18940864_ChIP-ChIP_HL60_Human1.37115729
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34583271
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31858254
86TTF2_22483619_ChIP-Seq_HELA_Human1.30726767
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.28817294
88* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28594286
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.28362895
90NANOG_18692474_ChIP-Seq_MESCs_Mouse1.27640702
91FOXP3_21729870_ChIP-Seq_TREG_Human1.27221160
92POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.26640822
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25678475
94NANOG_18692474_ChIP-Seq_MEFs_Mouse1.24631268
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24148010
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.23528514
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.22313773
98TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.21752336
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19675442
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19675442
101RNF2_27304074_Chip-Seq_NSC_Mouse1.19618419
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16541731
103CIITA_25753668_ChIP-Seq_RAJI_Human1.14864999
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.12006279
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10732813
106* SOX9_26525672_Chip-Seq_HEART_Mouse1.10482264
107POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.10397311
108* GATA1_26923725_Chip-Seq_HPCs_Mouse1.10297443
109* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09823910
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09693823
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08367087
112ELK1_19687146_ChIP-ChIP_HELA_Human1.08204576
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.07861252
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06143648
115TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05823988
116DCP1A_22483619_ChIP-Seq_HELA_Human1.05760002
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05595780
118* YY1_21170310_ChIP-Seq_MESCs_Mouse1.05517567
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.05443310
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05206822
121SMAD4_21799915_ChIP-Seq_A2780_Human1.05169226
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05135128
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04993232
124TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04978172
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04610291
126NANOG_16153702_ChIP-ChIP_HESCs_Human1.03898866
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03829561
128KDM5A_27292631_Chip-Seq_BREAST_Human1.03287426
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01145268
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01055524
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00121070
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99359333
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98067203
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97677563
135GABP_19822575_ChIP-Seq_HepG2_Human0.97269656
136* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96842146
137KAP1_27257070_Chip-Seq_ESCs_Mouse0.96554020
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95573287
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94776162
140* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93407028
141NANOG_16518401_ChIP-PET_MESCs_Mouse0.93050979
142KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92818100
143STAT3_23295773_ChIP-Seq_U87_Human0.92810036
144* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92146521
145CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91977652
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90758276
147PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88637052
148CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86915963
149NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84767987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.57988431
2MP0010094_abnormal_chromosome_stability4.32293324
3MP0003111_abnormal_nucleus_morphology3.96053900
4MP0003693_abnormal_embryo_hatching3.86592437
5MP0004957_abnormal_blastocyst_morpholog3.83261864
6MP0003077_abnormal_cell_cycle3.35436581
7MP0008058_abnormal_DNA_repair3.25680931
8MP0004133_heterotaxia2.59660735
9MP0003123_paternal_imprinting2.50176864
10MP0006292_abnormal_olfactory_placode2.44455624
11MP0001730_embryonic_growth_arrest2.33256320
12MP0000350_abnormal_cell_proliferation2.25603807
13MP0002653_abnormal_ependyma_morphology2.23229714
14MP0010352_gastrointestinal_tract_polyps2.22009249
15MP0001293_anophthalmia2.20130067
16MP0008932_abnormal_embryonic_tissue2.20120576
17MP0002084_abnormal_developmental_patter2.15341234
18MP0008007_abnormal_cellular_replicative2.12542997
19MP0003890_abnormal_embryonic-extraembry2.12345131
20MP0003121_genomic_imprinting2.08341445
21MP0003136_yellow_coat_color2.06389858
22MP0002085_abnormal_embryonic_tissue2.06143050
23MP0010307_abnormal_tumor_latency2.01597091
24MP0008877_abnormal_DNA_methylation1.97429662
25MP0003806_abnormal_nucleotide_metabolis1.95575682
26MP0001672_abnormal_embryogenesis/_devel1.94426176
27MP0005380_embryogenesis_phenotype1.94426176
28MP0002102_abnormal_ear_morphology1.94060162
29MP0003122_maternal_imprinting1.91299875
30MP0001529_abnormal_vocalization1.90407599
31MP0004197_abnormal_fetal_growth/weight/1.88730165
32MP0001697_abnormal_embryo_size1.84222889
33MP0003880_abnormal_central_pattern1.77489473
34MP0003119_abnormal_digestive_system1.75656874
35MP0003941_abnormal_skin_development1.74246747
36MP0003984_embryonic_growth_retardation1.68770217
37MP0002086_abnormal_extraembryonic_tissu1.68546326
38MP0000778_abnormal_nervous_system1.67789520
39MP0002088_abnormal_embryonic_growth/wei1.66417899
40MP0003786_premature_aging1.66027709
41MP0001188_hyperpigmentation1.59036172
42MP0002080_prenatal_lethality1.50276711
43MP0003718_maternal_effect1.47665031
44MP0003937_abnormal_limbs/digits/tail_de1.45127502
45MP0003567_abnormal_fetal_cardiomyocyte1.44713152
46MP0010030_abnormal_orbit_morphology1.44058976
47MP0005076_abnormal_cell_differentiation1.43730009
48MP0005367_renal/urinary_system_phenotyp1.38161739
49MP0000516_abnormal_urinary_system1.38161739
50MP0003787_abnormal_imprinting1.37324081
51MP0009697_abnormal_copulation1.37242864
52MP0001299_abnormal_eye_distance/1.32444110
53MP0000631_abnormal_neuroendocrine_gland1.31450722
54MP0001286_abnormal_eye_development1.30688313
55MP0002254_reproductive_system_inflammat1.28786630
56MP0002210_abnormal_sex_determination1.26478587
57MP0003283_abnormal_digestive_organ1.26203767
58MP0003861_abnormal_nervous_system1.25966395
59MP0009703_decreased_birth_body1.25240672
60MP0006072_abnormal_retinal_apoptosis1.25161910
61MP0006276_abnormal_autonomic_nervous1.23860029
62MP0003315_abnormal_perineum_morphology1.23072702
63MP0003938_abnormal_ear_development1.20874176
64MP0000647_abnormal_sebaceous_gland1.19600452
65MP0001849_ear_inflammation1.18270681
66MP0002234_abnormal_pharynx_morphology1.17658764
67MP0000537_abnormal_urethra_morphology1.16043673
68MP0001145_abnormal_male_reproductive1.15920696
69MP0005248_abnormal_Harderian_gland1.15877913
70MP0002697_abnormal_eye_size1.14269846
71MP0003385_abnormal_body_wall1.13386967
72MP0005187_abnormal_penis_morphology1.09262807
73MP0009672_abnormal_birth_weight1.08576893
74MP0002111_abnormal_tail_morphology1.07152590
75MP0004145_abnormal_muscle_electrophysio1.06544507
76MP0003950_abnormal_plasma_membrane1.06468066
77MP0000313_abnormal_cell_death1.06357801
78MP0002736_abnormal_nociception_after1.05768010
79MP0001984_abnormal_olfaction1.04878859
80MP0000432_abnormal_head_morphology1.00767908
81MP0005253_abnormal_eye_physiology1.00341034
82MP0003942_abnormal_urinary_system0.99805639
83MP0002092_abnormal_eye_morphology0.98522653
84MP0002822_catalepsy0.97477331
85MP0002184_abnormal_innervation0.96723398
86MP0001929_abnormal_gametogenesis0.96391184
87MP0001348_abnormal_lacrimal_gland0.96290324
88MP0003755_abnormal_palate_morphology0.95546664
89MP0005623_abnormal_meninges_morphology0.95054943
90MP0000653_abnormal_sex_gland0.92684839
91MP0001346_abnormal_lacrimal_gland0.91924431
92MP0004264_abnormal_extraembryonic_tissu0.90949120
93MP0001177_atelectasis0.90629481
94MP0003936_abnormal_reproductive_system0.90040809
95MP0003935_abnormal_craniofacial_develop0.89706966
96MP0002249_abnormal_larynx_morphology0.88929325
97MP0008995_early_reproductive_senescence0.88745941
98MP0009053_abnormal_anal_canal0.88078865
99MP0005551_abnormal_eye_electrophysiolog0.87413218
100MP0002752_abnormal_somatic_nervous0.87387936
101MP0000955_abnormal_spinal_cord0.86905643
102MP0000490_abnormal_crypts_of0.86832157
103MP0004885_abnormal_endolymph0.85837910
104MP0001485_abnormal_pinna_reflex0.85306476
105MP0002638_abnormal_pupillary_reflex0.81762550
106MP0004270_analgesia0.81112083
107MP0005195_abnormal_posterior_eye0.81027593
108MP0002751_abnormal_autonomic_nervous0.80850226
109MP0002396_abnormal_hematopoietic_system0.80780660
110MP0001486_abnormal_startle_reflex0.80388093
111MP0008789_abnormal_olfactory_epithelium0.80114726
112MP0002233_abnormal_nose_morphology0.80101568
113MP0005391_vision/eye_phenotype0.79897538
114MP0002160_abnormal_reproductive_system0.79107298
115MP0000428_abnormal_craniofacial_morphol0.78431790
116MP0005377_hearing/vestibular/ear_phenot0.78202462
117MP0003878_abnormal_ear_physiology0.78202462
118MP0006035_abnormal_mitochondrial_morpho0.76794381
119MP0000049_abnormal_middle_ear0.74639033
120MP0002925_abnormal_cardiovascular_devel0.72636037
121MP0003698_abnormal_male_reproductive0.72210833
122MP0002938_white_spotting0.72029147
123MP0005266_abnormal_metabolism0.71423817
124MP0005499_abnormal_olfactory_system0.69940338
125MP0005394_taste/olfaction_phenotype0.69940338
126MP0002019_abnormal_tumor_incidence0.69238613
127MP0005384_cellular_phenotype0.68798275
128MP0002114_abnormal_axial_skeleton0.68388247
129MP0002075_abnormal_coat/hair_pigmentati0.66388506
130MP0000566_synostosis0.63678456
131MP0003566_abnormal_cell_adhesion0.63635100
132MP0002081_perinatal_lethality0.62702029
133MP0002127_abnormal_cardiovascular_syste0.62395500
134MP0002116_abnormal_craniofacial_bone0.61986366
135MP0005621_abnormal_cell_physiology0.60646350
136MP0002152_abnormal_brain_morphology0.59978119
137MP0008770_decreased_survivor_rate0.57522968

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.25569117
2Abnormality of the labia minora (HP:0012880)4.85453467
3Medulloblastoma (HP:0002885)4.33916087
4Chromsome breakage (HP:0040012)4.30219677
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.29423715
6Neoplasm of the oral cavity (HP:0100649)4.07563996
7Abnormality of the astrocytes (HP:0100707)3.95196436
8Astrocytoma (HP:0009592)3.95196436
9Supernumerary spleens (HP:0009799)3.89405900
10Absent radius (HP:0003974)3.54390231
11Birth length less than 3rd percentile (HP:0003561)3.53871340
12Glioma (HP:0009733)3.48114090
13Hepatoblastoma (HP:0002884)3.44581086
14Agnosia (HP:0010524)3.42177424
15Aplasia involving forearm bones (HP:0009822)3.37762387
16Absent forearm bone (HP:0003953)3.37762387
17Rhabdomyosarcoma (HP:0002859)3.32305447
18Cortical dysplasia (HP:0002539)3.18750455
19Abnormality of chromosome stability (HP:0003220)3.09920107
20Colon cancer (HP:0003003)3.09522481
21Aplasia/Hypoplasia of the uvula (HP:0010293)3.01691157
22Esophageal atresia (HP:0002032)2.97597947
23Meckel diverticulum (HP:0002245)2.96597456
24Selective tooth agenesis (HP:0001592)2.95544132
25Impulsivity (HP:0100710)2.93334336
26Abnormality of abdominal situs (HP:0011620)2.92109334
27Abdominal situs inversus (HP:0003363)2.92109334
28Breast hypoplasia (HP:0003187)2.90232373
29Abnormality of the ileum (HP:0001549)2.83855027
30Neoplasm of striated muscle (HP:0009728)2.83549653
31Patellar aplasia (HP:0006443)2.82984349
32Abnormal number of incisors (HP:0011064)2.82894644
33Abnormality of the preputium (HP:0100587)2.80603159
34Hyperglycinemia (HP:0002154)2.73281834
35Shawl scrotum (HP:0000049)2.71617522
36Aplasia/hypoplasia of the humerus (HP:0006507)2.69665086
37Short humerus (HP:0005792)2.59395064
38Rectal fistula (HP:0100590)2.57451343
39Rectovaginal fistula (HP:0000143)2.57451343
40Biliary tract neoplasm (HP:0100574)2.57125950
41Bifid tongue (HP:0010297)2.56412842
42Volvulus (HP:0002580)2.56113363
43Aplasia/Hypoplasia of the patella (HP:0006498)2.55626822
44Rib fusion (HP:0000902)2.53081568
45Abnormality of the salivary glands (HP:0010286)2.50695163
46Anal stenosis (HP:0002025)2.45828310
47Absent thumb (HP:0009777)2.45521882
48Ectopic kidney (HP:0000086)2.44746591
49Gastrointestinal atresia (HP:0002589)2.41880854
50Small intestinal stenosis (HP:0012848)2.41690387
51Duodenal stenosis (HP:0100867)2.41690387
52Stenosis of the external auditory canal (HP:0000402)2.39586252
53High anterior hairline (HP:0009890)2.39172142
54Intestinal fistula (HP:0100819)2.39052326
55Bilateral microphthalmos (HP:0007633)2.38994397
56Carpal bone hypoplasia (HP:0001498)2.36556558
57Proximal placement of thumb (HP:0009623)2.32806553
58Duplicated collecting system (HP:0000081)2.30569872
59Oral leukoplakia (HP:0002745)2.30032737
60Vaginal atresia (HP:0000148)2.24915803
61Missing ribs (HP:0000921)2.24911255
62Genital tract atresia (HP:0001827)2.24694143
63Deviation of the thumb (HP:0009603)2.23703460
64Abnormality of the duodenum (HP:0002246)2.23158433
65Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.23102188
66Short 1st metacarpal (HP:0010034)2.23102188
67Pancreatic fibrosis (HP:0100732)2.21673168
68Supernumerary bones of the axial skeleton (HP:0009144)2.19307556
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.16683920
70Supernumerary ribs (HP:0005815)2.16362335
71Asplenia (HP:0001746)2.16261395
72Septo-optic dysplasia (HP:0100842)2.15061679
73Sloping forehead (HP:0000340)2.14083215
74Short thumb (HP:0009778)2.14050451
75Amaurosis fugax (HP:0100576)2.13273957
76Reticulocytopenia (HP:0001896)2.12416262
77Cutaneous finger syndactyly (HP:0010554)2.11254670
78Horseshoe kidney (HP:0000085)2.08034381
79True hermaphroditism (HP:0010459)2.06996239
80Pancreatic cysts (HP:0001737)2.05273537
81Intestinal atresia (HP:0011100)2.04794487
82Renal hypoplasia (HP:0000089)2.04014263
83Abnormality of the carotid arteries (HP:0005344)2.03749511
84Tracheoesophageal fistula (HP:0002575)2.02835654
85Basal cell carcinoma (HP:0002671)2.02651074
86Nephroblastoma (Wilms tumor) (HP:0002667)2.01019293
87Triphalangeal thumb (HP:0001199)2.00325773
88Myelodysplasia (HP:0002863)2.00264048
89Absent eyebrow (HP:0002223)1.98470706
90Abnormality of the septum pellucidum (HP:0007375)1.97876153
91Neoplasm of the pancreas (HP:0002894)1.97206581
92Cutaneous syndactyly (HP:0012725)1.97150424
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96453958
94Bone marrow hypocellularity (HP:0005528)1.95945912
95Vaginal fistula (HP:0004320)1.95911655
96Absent septum pellucidum (HP:0001331)1.95628091
97Abnormality of the renal collecting system (HP:0004742)1.95454050
98Short phalanx of the thumb (HP:0009660)1.94396732
99Anophthalmia (HP:0000528)1.94228856
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93556330
101Increased nuchal translucency (HP:0010880)1.92612914
102Optic nerve hypoplasia (HP:0000609)1.92575308
103Preaxial hand polydactyly (HP:0001177)1.92472207
104Aplasia/Hypoplasia of the spleen (HP:0010451)1.92463490
105Cafe-au-lait spot (HP:0000957)1.92115659
106Midline defect of the nose (HP:0004122)1.90052741
107Drooling (HP:0002307)1.89453205
108Hemivertebrae (HP:0002937)1.88715606
109Cerebral hypomyelination (HP:0006808)1.88458931
110Abnormality of the antihelix (HP:0009738)1.88419363
111Hypoplastic female external genitalia (HP:0012815)1.88233706
112Labial hypoplasia (HP:0000066)1.88232150
113Facial hemangioma (HP:0000329)1.86467427
114Abnormality of the 1st metacarpal (HP:0010009)1.86003221
115Duplication of thumb phalanx (HP:0009942)1.84790709
116Embryonal renal neoplasm (HP:0011794)1.83713037
117Prominent nose (HP:0000448)1.82346408
118Abnormal hair whorl (HP:0010721)1.82210400
119Skull defect (HP:0001362)1.82100729
120Chronic hepatic failure (HP:0100626)1.81348723
121Poor coordination (HP:0002370)1.80965398
122Nephronophthisis (HP:0000090)1.80939163
123Congenital primary aphakia (HP:0007707)1.80318477
124Abnormal lung lobation (HP:0002101)1.79657547
125Rough bone trabeculation (HP:0100670)1.79233936
126Nephrogenic diabetes insipidus (HP:0009806)1.79041728
127Oligodactyly (hands) (HP:0001180)1.78860865
128Broad foot (HP:0001769)1.78857403
129Gait imbalance (HP:0002141)1.78594595
130Preaxial foot polydactyly (HP:0001841)1.78144616
131Abnormality of glycine metabolism (HP:0010895)1.77833741
132Abnormality of serine family amino acid metabolism (HP:0010894)1.77833741
133Dandy-Walker malformation (HP:0001305)1.77180802
134Gastrointestinal carcinoma (HP:0002672)1.76974958
135Malignant gastrointestinal tract tumors (HP:0006749)1.76974958
136Myelomeningocele (HP:0002475)1.76555316
137Anencephaly (HP:0002323)1.75714636
138Aqueductal stenosis (HP:0002410)1.75105448
139Medial flaring of the eyebrow (HP:0010747)1.74057377
140Cupped ear (HP:0000378)1.73340625
141Neoplasm of the adrenal cortex (HP:0100641)1.72696750
142Facial cleft (HP:0002006)1.72322442
143Hyperglycinuria (HP:0003108)1.71921533
144Micropenis (HP:0000054)1.71630165
145Abnormality of serum amino acid levels (HP:0003112)1.67167972
146Bicornuate uterus (HP:0000813)1.65915236
147Postaxial foot polydactyly (HP:0001830)1.64491516
148Abnormality of midbrain morphology (HP:0002418)1.63652537
149Molar tooth sign on MRI (HP:0002419)1.63652537
150Scrotal hypoplasia (HP:0000046)1.62368559
151Excessive salivation (HP:0003781)1.61552942
152Choanal stenosis (HP:0000452)1.60398383
153Sclerocornea (HP:0000647)1.60214696
154Partial agenesis of the corpus callosum (HP:0001338)1.59128553
155Vitreoretinal degeneration (HP:0000655)1.58320329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.27109396
2CDK124.19366574
3WEE14.00546287
4EPHA23.54935805
5PNCK3.20806647
6SRPK12.90265498
7TTK2.80954776
8BUB12.78466257
9NEK12.72770272
10TNIK2.69606303
11AKT32.41663890
12CASK2.40852801
13TSSK62.31700442
14BRD42.23854890
15TLK12.18868724
16NEK22.12019600
17PLK12.08269374
18MAP3K42.07575751
19PLK32.03870167
20ZAK2.02004755
21CHEK21.93175725
22NUAK11.92900816
23ATR1.86612243
24TRIM281.85934069
25CDK71.84786389
26MKNK11.78201805
27RPS6KB21.77614732
28MKNK21.76703779
29EIF2AK11.73743906
30VRK11.70750787
31CHEK11.59207571
32BMPR1B1.58633263
33PASK1.52070783
34EPHA41.46133309
35CDK191.44421273
36AURKB1.40690181
37ATM1.36793496
38TAF11.36454761
39BRSK21.35105622
40DYRK31.28536321
41MET1.28461001
42MARK11.25702291
43MAP2K71.23165202
44WNK41.21503313
45AURKA1.20319370
46CDK41.17301213
47CAMK1G1.16923826
48CDK21.16889224
49STK391.14225847
50CSNK1G21.14175517
51MAP4K21.12619384
52MAP3K81.08450742
53PLK41.07184440
54ACVR1B1.06656014
55STK41.06538771
56EIF2AK31.06339578
57ALK1.05421607
58WNK31.02001059
59OXSR11.01820072
60FLT31.00746265
61STK38L1.00422788
62PLK20.98712534
63MAPK130.97123291
64OBSCN0.95745050
65CDK10.94861479
66CSNK1D0.94853206
67BCR0.87981131
68FRK0.87259621
69LATS20.87065596
70VRK20.85479983
71PRKCI0.84108768
72MTOR0.82692874
73BRAF0.75857536
74INSRR0.75131604
75SCYL20.74879515
76CSNK1E0.74686067
77CSNK2A20.74557782
78TESK20.73933828
79DYRK20.73428442
80LATS10.71330991
81NLK0.71205119
82RPS6KA50.70232456
83ERBB40.69040360
84PRKDC0.66127539
85NTRK20.65632821
86CDK30.61849252
87RPS6KA40.60929885
88YES10.60787857
89PRKCG0.60142538
90CDK60.59354680
91MINK10.59189102
92PINK10.58897997
93MAPK140.58849696
94NEK60.58795687
95MELK0.58533171
96PIM10.56773856
97ICK0.56121251
98GSK3B0.55494228
99PBK0.55443716
100STK160.55350746
101AKT20.54661255
102BRSK10.53706052
103GRK10.52612859
104FGFR10.51681982
105CSNK2A10.49807087
106TIE10.49159955
107EIF2AK20.46532874
108CAMK1D0.46434738
109MAPK10.46394273
110PRPF4B0.45901918
111MAPK100.45233933
112MST40.44312762
113PAK10.43795194
114FGFR20.40433055
115EEF2K0.40183491
116TGFBR10.38857770
117AKT10.38431890
118SGK20.37584776
119SGK2230.37308543
120SGK4940.37308543
121PRKCE0.36541345
122NME10.36377613
123CSNK1G10.34920261
124DYRK1A0.34829576
125PAK40.34248731
126DMPK0.33300417
127STK30.30295783
128KSR10.30242318
129CSNK1A1L0.29401611
130CSNK1G30.28270781
131MAPK80.26440915
132PDK20.25228644
133RPS6KB10.22624387
134TYRO30.22362278
135ERBB30.21923194
136CDK90.21559344
137MAPK90.18260683
138TAOK20.18191829
139MAP3K100.17768721

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.95720348
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.28560926
3DNA replication_Homo sapiens_hsa030304.27239593
4RNA transport_Homo sapiens_hsa030133.49232490
5Spliceosome_Homo sapiens_hsa030403.31603693
6RNA polymerase_Homo sapiens_hsa030203.20092083
7Fanconi anemia pathway_Homo sapiens_hsa034603.11860923
8Homologous recombination_Homo sapiens_hsa034403.04831161
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.03839388
10Nucleotide excision repair_Homo sapiens_hsa034203.01249441
11One carbon pool by folate_Homo sapiens_hsa006702.99206392
12Cell cycle_Homo sapiens_hsa041102.86658628
13Non-homologous end-joining_Homo sapiens_hsa034502.82408892
14Base excision repair_Homo sapiens_hsa034102.53019339
15Steroid biosynthesis_Homo sapiens_hsa001002.41976972
16mRNA surveillance pathway_Homo sapiens_hsa030152.29590948
17Systemic lupus erythematosus_Homo sapiens_hsa053222.12534984
18RNA degradation_Homo sapiens_hsa030182.11562001
19Basal transcription factors_Homo sapiens_hsa030222.09172804
20Pyrimidine metabolism_Homo sapiens_hsa002401.94661445
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93198989
22Propanoate metabolism_Homo sapiens_hsa006401.84919629
23Ribosome_Homo sapiens_hsa030101.83278780
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.72781236
25Proteasome_Homo sapiens_hsa030501.62979844
26Protein export_Homo sapiens_hsa030601.58314723
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51039297
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50973062
29p53 signaling pathway_Homo sapiens_hsa041151.47359559
30Basal cell carcinoma_Homo sapiens_hsa052171.41120655
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30875692
32Alcoholism_Homo sapiens_hsa050341.27713617
33Oocyte meiosis_Homo sapiens_hsa041141.25776337
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20725574
35Purine metabolism_Homo sapiens_hsa002301.18847670
36Pyruvate metabolism_Homo sapiens_hsa006201.17094314
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11084466
38Hippo signaling pathway_Homo sapiens_hsa043901.10141466
39Viral carcinogenesis_Homo sapiens_hsa052031.10008872
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03384100
41Parkinsons disease_Homo sapiens_hsa050121.01070044
42Hedgehog signaling pathway_Homo sapiens_hsa043401.00433454
43Epstein-Barr virus infection_Homo sapiens_hsa051690.97996271
44MicroRNAs in cancer_Homo sapiens_hsa052060.97559132
45Oxidative phosphorylation_Homo sapiens_hsa001900.94523129
46Butanoate metabolism_Homo sapiens_hsa006500.88750022
47Notch signaling pathway_Homo sapiens_hsa043300.86553837
48Biosynthesis of amino acids_Homo sapiens_hsa012300.84967876
49Fatty acid elongation_Homo sapiens_hsa000620.79828032
50TGF-beta signaling pathway_Homo sapiens_hsa043500.79704980
51Taste transduction_Homo sapiens_hsa047420.75770781
52Lysine degradation_Homo sapiens_hsa003100.72615288
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71916073
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71392392
55Wnt signaling pathway_Homo sapiens_hsa043100.69132981
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.66159142
57HTLV-I infection_Homo sapiens_hsa051660.63741176
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.63608099
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63418941
60Tight junction_Homo sapiens_hsa045300.62814440
61Colorectal cancer_Homo sapiens_hsa052100.61631034
62Fatty acid metabolism_Homo sapiens_hsa012120.61598448
63Adherens junction_Homo sapiens_hsa045200.61131760
64Cardiac muscle contraction_Homo sapiens_hsa042600.60175778
65Olfactory transduction_Homo sapiens_hsa047400.57399069
66Selenocompound metabolism_Homo sapiens_hsa004500.56857569
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56815453
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55460207
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54531239
70Thyroid cancer_Homo sapiens_hsa052160.53313454
71Fructose and mannose metabolism_Homo sapiens_hsa000510.52929833
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52840446
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52418045
74Peroxisome_Homo sapiens_hsa041460.50796457
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50441467
76mTOR signaling pathway_Homo sapiens_hsa041500.49999401
77Pathways in cancer_Homo sapiens_hsa052000.49566161
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48183566
79Vitamin digestion and absorption_Homo sapiens_hsa049770.46794843
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45750241
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44660660
82Herpes simplex infection_Homo sapiens_hsa051680.44174873
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43973910
84GABAergic synapse_Homo sapiens_hsa047270.43085672
85Vitamin B6 metabolism_Homo sapiens_hsa007500.42353877
86Folate biosynthesis_Homo sapiens_hsa007900.42244690
87Melanoma_Homo sapiens_hsa052180.41732357
88Nitrogen metabolism_Homo sapiens_hsa009100.40926975
89beta-Alanine metabolism_Homo sapiens_hsa004100.40165230
90Pentose phosphate pathway_Homo sapiens_hsa000300.39265699
91Alzheimers disease_Homo sapiens_hsa050100.38765010
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.38339092
93Prostate cancer_Homo sapiens_hsa052150.35241338
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34954324
95Retinol metabolism_Homo sapiens_hsa008300.34022905
96Antigen processing and presentation_Homo sapiens_hsa046120.32940350
97Fat digestion and absorption_Homo sapiens_hsa049750.32811875
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.32751031
99Small cell lung cancer_Homo sapiens_hsa052220.32004492
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31689029
101Ether lipid metabolism_Homo sapiens_hsa005650.30880208
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30808612
103Tryptophan metabolism_Homo sapiens_hsa003800.30147867
104Regulation of autophagy_Homo sapiens_hsa041400.28965768
105Glutamatergic synapse_Homo sapiens_hsa047240.27979144
106Endometrial cancer_Homo sapiens_hsa052130.27292321
107Fatty acid degradation_Homo sapiens_hsa000710.27180595
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26357190
109Dopaminergic synapse_Homo sapiens_hsa047280.25490363
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24945730
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.24569011
112Fatty acid biosynthesis_Homo sapiens_hsa000610.24489895
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21251109
114Bladder cancer_Homo sapiens_hsa052190.18598203
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18594431
116Carbon metabolism_Homo sapiens_hsa012000.18195624
117Huntingtons disease_Homo sapiens_hsa050160.16852372
118Glutathione metabolism_Homo sapiens_hsa004800.15963540
119HIF-1 signaling pathway_Homo sapiens_hsa040660.15610987
120FoxO signaling pathway_Homo sapiens_hsa040680.13298338
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12846115
122Renal cell carcinoma_Homo sapiens_hsa052110.12318464
123Phototransduction_Homo sapiens_hsa047440.10938628
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.10555386
125Melanogenesis_Homo sapiens_hsa049160.08522250
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07131891
127Arginine and proline metabolism_Homo sapiens_hsa003300.06679169
128Linoleic acid metabolism_Homo sapiens_hsa005910.06006111
129Inositol phosphate metabolism_Homo sapiens_hsa005620.04759748
130Proteoglycans in cancer_Homo sapiens_hsa052050.03945473
131Metabolic pathways_Homo sapiens_hsa011000.02804669
132ErbB signaling pathway_Homo sapiens_hsa040120.02061224
133AMPK signaling pathway_Homo sapiens_hsa041520.01253901
134Axon guidance_Homo sapiens_hsa04360-0.0470058
135Glucagon signaling pathway_Homo sapiens_hsa04922-0.0409756
136Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0387808
137Apoptosis_Homo sapiens_hsa04210-0.0325696
138Non-small cell lung cancer_Homo sapiens_hsa05223-0.0293334
139Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0251048
140Nicotine addiction_Homo sapiens_hsa05033-0.0176074

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