TET1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine catabolic process (GO:0006554)4.25607222
2lysine metabolic process (GO:0006553)4.25607222
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.15204992
4cell wall macromolecule catabolic process (GO:0016998)4.14843186
5proteasome assembly (GO:0043248)4.07599426
6serotonin metabolic process (GO:0042428)3.95303184
7cell wall macromolecule metabolic process (GO:0044036)3.93984157
8replication fork processing (GO:0031297)3.92653359
9water-soluble vitamin biosynthetic process (GO:0042364)3.91377493
10monoubiquitinated protein deubiquitination (GO:0035520)3.83744381
11indolalkylamine metabolic process (GO:0006586)3.80890675
12attachment of spindle microtubules to kinetochore (GO:0008608)3.80373207
13lactate metabolic process (GO:0006089)3.76919913
14cullin deneddylation (GO:0010388)3.76725775
15regulation of Golgi to plasma membrane protein transport (GO:0042996)3.74219277
16mitotic metaphase plate congression (GO:0007080)3.71849982
17spindle checkpoint (GO:0031577)3.69448423
18maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.59145956
19DNA replication checkpoint (GO:0000076)3.45307456
20auditory receptor cell differentiation (GO:0042491)3.45115069
21mitotic spindle checkpoint (GO:0071174)3.44081272
22DNA double-strand break processing (GO:0000729)3.43492334
23primary amino compound metabolic process (GO:1901160)3.43353792
24DNA demethylation (GO:0080111)3.42299075
25resolution of meiotic recombination intermediates (GO:0000712)3.41385165
26chromatin remodeling at centromere (GO:0031055)3.39819104
27histone exchange (GO:0043486)3.39795999
28DNA replication-independent nucleosome organization (GO:0034724)3.39738548
29DNA replication-independent nucleosome assembly (GO:0006336)3.39738548
30signal peptide processing (GO:0006465)3.34533222
31indole-containing compound metabolic process (GO:0042430)3.32322972
32CENP-A containing nucleosome assembly (GO:0034080)3.31367441
33protein localization to kinetochore (GO:0034501)3.30636695
34RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.28959175
35protein deneddylation (GO:0000338)3.28501320
36metaphase plate congression (GO:0051310)3.21934022
37negative regulation of mitotic sister chromatid separation (GO:2000816)3.21395831
38negative regulation of sister chromatid segregation (GO:0033046)3.21395831
39negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21395831
40negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.21395831
41negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21395831
42protein polyglutamylation (GO:0018095)3.20856003
43negative regulation of chromosome segregation (GO:0051985)3.19952910
44mitotic spindle assembly checkpoint (GO:0007094)3.18516011
45regulation of cilium movement (GO:0003352)3.18419401
46spindle assembly checkpoint (GO:0071173)3.16555964
47regulation of timing of cell differentiation (GO:0048505)3.14219053
48negative regulation of DNA recombination (GO:0045910)3.09182405
49aspartate family amino acid catabolic process (GO:0009068)3.09129148
50glyoxylate metabolic process (GO:0046487)3.05780076
51positive regulation of mitochondrial fission (GO:0090141)3.05102176
52somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03564540
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.03564540
54mitochondrial RNA metabolic process (GO:0000959)3.03530321
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.99811174
56regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99811174
57regulation of development, heterochronic (GO:0040034)2.99799994
58regulation of nuclear cell cycle DNA replication (GO:0033262)2.99192129
59establishment of chromosome localization (GO:0051303)2.98314935
60DNA replication-dependent nucleosome assembly (GO:0006335)2.93477533
61DNA replication-dependent nucleosome organization (GO:0034723)2.93477533
62olfactory bulb development (GO:0021772)2.91036495
63negative regulation of DNA-dependent DNA replication (GO:2000104)2.90160332
64thrombin receptor signaling pathway (GO:0070493)2.89919258
65protein localization to chromosome, centromeric region (GO:0071459)2.89301338
66negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.88197375
67regulation of sister chromatid segregation (GO:0033045)2.86318889
68regulation of mitotic sister chromatid separation (GO:0010965)2.86318889
69regulation of mitotic sister chromatid segregation (GO:0033047)2.86318889
70non-recombinational repair (GO:0000726)2.83501478
71double-strand break repair via nonhomologous end joining (GO:0006303)2.83501478
72peroxisome fission (GO:0016559)2.82994907
73maturation of 5.8S rRNA (GO:0000460)2.79287038
74regulation of chromosome segregation (GO:0051983)2.76052349
75platelet dense granule organization (GO:0060155)2.75087075
76neuron cell-cell adhesion (GO:0007158)2.72754368
77tryptophan metabolic process (GO:0006568)2.71838155
78ventricular trabecula myocardium morphogenesis (GO:0003222)2.71603065
79epithelial cilium movement (GO:0003351)2.68933233
80DNA dealkylation (GO:0035510)2.68478752
81mitotic sister chromatid segregation (GO:0000070)2.68374103
82Notch signaling involved in heart development (GO:0061314)2.67820165
83cardiac right ventricle morphogenesis (GO:0003215)2.66584800
84hair cell differentiation (GO:0035315)2.66436158
85N-terminal protein amino acid acetylation (GO:0006474)2.65771810
86seminiferous tubule development (GO:0072520)2.65595497
87presynaptic membrane assembly (GO:0097105)2.63179182
88negative regulation of gene silencing (GO:0060969)2.60602059
89DNA ligation (GO:0006266)2.59553481
90microtubule depolymerization (GO:0007019)2.56323963
91kinetochore assembly (GO:0051382)2.54731540
92sister chromatid segregation (GO:0000819)2.54099673
93regulation of axon regeneration (GO:0048679)2.54089618
94regulation of neuron projection regeneration (GO:0070570)2.54089618
95protein neddylation (GO:0045116)2.53362563
96oxidative demethylation (GO:0070989)2.52796656
97L-serine metabolic process (GO:0006563)2.52291479
98microtubule anchoring (GO:0034453)2.50776517
99regulation of helicase activity (GO:0051095)2.50451114
100negative regulation of mitosis (GO:0045839)2.49986102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.44183969
2IGF1R_20145208_ChIP-Seq_DFB_Human3.57064208
3ZNF274_21170338_ChIP-Seq_K562_Hela3.23508741
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92678893
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.88173497
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79985219
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.72643893
8GBX2_23144817_ChIP-Seq_PC3_Human2.70028504
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68473064
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65382875
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60793083
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58385731
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.55175930
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55033101
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47471179
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46325454
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.42227961
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.37929009
19TAF15_26573619_Chip-Seq_HEK293_Human2.36917477
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.32865927
21EWS_26573619_Chip-Seq_HEK293_Human2.24142121
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20176461
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00926213
24FUS_26573619_Chip-Seq_HEK293_Human2.00215109
25ELK1_19687146_ChIP-ChIP_HELA_Human1.98505623
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94489254
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88826045
28P300_19829295_ChIP-Seq_ESCs_Human1.74691440
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74273956
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68362257
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62451248
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57381906
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55204013
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54778472
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52984303
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47814680
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42239755
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.39761701
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.39506573
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39369995
41VDR_23849224_ChIP-Seq_CD4+_Human1.39194841
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37973807
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37952899
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37255523
45IRF1_19129219_ChIP-ChIP_H3396_Human1.34115865
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32791034
47CBP_20019798_ChIP-Seq_JUKART_Human1.32791034
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32786538
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32577058
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30226003
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30189733
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29640434
53MYC_18940864_ChIP-ChIP_HL60_Human1.28733139
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28041743
55SMAD4_21799915_ChIP-Seq_A2780_Human1.27850966
56TCF4_22108803_ChIP-Seq_LS180_Human1.25203041
57BCAT_22108803_ChIP-Seq_LS180_Human1.21331828
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20704970
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19799982
60ER_23166858_ChIP-Seq_MCF-7_Human1.19100458
61STAT3_23295773_ChIP-Seq_U87_Human1.18834803
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.16020919
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15697448
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.15498383
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15239962
66NANOG_19829295_ChIP-Seq_ESCs_Human1.14775137
67SOX2_19829295_ChIP-Seq_ESCs_Human1.14775137
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13152253
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09835508
70TP53_22573176_ChIP-Seq_HFKS_Human1.06442179
71AR_25329375_ChIP-Seq_VCAP_Human1.06055561
72TCF4_23295773_ChIP-Seq_U87_Human1.05933945
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04454689
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.03095029
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02150964
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.01574103
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01457983
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01401082
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00628959
80RUNX2_22187159_ChIP-Seq_PCA_Human1.00049539
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00009571
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99276053
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99263266
84JUN_21703547_ChIP-Seq_K562_Human0.99107784
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98523905
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96783070
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95989309
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.95905222
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.95643646
90SMAD3_21741376_ChIP-Seq_EPCs_Human0.94959095
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.94848708
92P53_22387025_ChIP-Seq_ESCs_Mouse0.94836795
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.93878301
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93652778
95TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93433509
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.93373715
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92095356
98TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91802678
99P300_18555785_Chip-Seq_ESCs_Mouse0.91661408
100SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91355238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.06878021
2MP0010094_abnormal_chromosome_stability2.99405936
3MP0003693_abnormal_embryo_hatching2.96939426
4MP0003890_abnormal_embryonic-extraembry2.89114354
5MP0002837_dystrophic_cardiac_calcinosis2.85646368
6MP0003880_abnormal_central_pattern2.85454352
7MP0008058_abnormal_DNA_repair2.84542314
8MP0002653_abnormal_ependyma_morphology2.75227801
9MP0006054_spinal_hemorrhage2.71814204
10MP0003195_calcinosis2.58888965
11MP0008877_abnormal_DNA_methylation2.50111999
12MP0000516_abnormal_urinary_system2.32234027
13MP0005367_renal/urinary_system_phenotyp2.32234027
14MP0001986_abnormal_taste_sensitivity1.99226053
15MP0003718_maternal_effect1.97158387
16MP0002938_white_spotting1.95929183
17MP0008789_abnormal_olfactory_epithelium1.94883516
18MP0002735_abnormal_chemical_nociception1.88759002
19MP0006072_abnormal_retinal_apoptosis1.86345018
20MP0002736_abnormal_nociception_after1.82611232
21MP0004957_abnormal_blastocyst_morpholog1.80936746
22MP0001486_abnormal_startle_reflex1.74621329
23MP0003121_genomic_imprinting1.71264640
24MP0006276_abnormal_autonomic_nervous1.66679413
25MP0001529_abnormal_vocalization1.65149694
26MP0005253_abnormal_eye_physiology1.64557300
27MP0003077_abnormal_cell_cycle1.62236839
28MP0003941_abnormal_skin_development1.59565799
29MP0005551_abnormal_eye_electrophysiolog1.57728375
30MP0002751_abnormal_autonomic_nervous1.55458307
31MP0004215_abnormal_myocardial_fiber1.54846493
32MP0001485_abnormal_pinna_reflex1.51011142
33MP0008932_abnormal_embryonic_tissue1.49204251
34MP0004133_heterotaxia1.48902745
35MP0009046_muscle_twitch1.46936265
36MP0004019_abnormal_vitamin_homeostasis1.46482736
37MP0003111_abnormal_nucleus_morphology1.46367438
38MP0003119_abnormal_digestive_system1.44142194
39MP0005499_abnormal_olfactory_system1.43970853
40MP0005394_taste/olfaction_phenotype1.43970853
41MP0000569_abnormal_digit_pigmentation1.41572767
42MP0000647_abnormal_sebaceous_gland1.39943403
43MP0008007_abnormal_cellular_replicative1.38614660
44MP0003567_abnormal_fetal_cardiomyocyte1.38006249
45MP0004885_abnormal_endolymph1.36697780
46MP0006036_abnormal_mitochondrial_physio1.33786196
47MP0003943_abnormal_hepatobiliary_system1.21194512
48MP0002234_abnormal_pharynx_morphology1.20966041
49MP0008775_abnormal_heart_ventricle1.19845928
50MP0009697_abnormal_copulation1.19690010
51MP0004147_increased_porphyrin_level1.19068008
52MP0001968_abnormal_touch/_nociception1.18413814
53MP0006035_abnormal_mitochondrial_morpho1.16788555
54MP0004233_abnormal_muscle_weight1.16782451
55MP0005171_absent_coat_pigmentation1.12669124
56MP0003646_muscle_fatigue1.09653208
57MP0001501_abnormal_sleep_pattern1.08906279
58MP0001764_abnormal_homeostasis1.06793796
59MP0005167_abnormal_blood-brain_barrier1.06127990
60MP0004084_abnormal_cardiac_muscle1.04942173
61MP0001929_abnormal_gametogenesis1.03932176
62MP0002557_abnormal_social/conspecific_i1.02978810
63MP0009703_decreased_birth_body1.01233954
64MP0002572_abnormal_emotion/affect_behav1.00501286
65MP0000778_abnormal_nervous_system1.00311199
66MP0004742_abnormal_vestibular_system1.00184970
67MP0002638_abnormal_pupillary_reflex0.98230504
68MP0001672_abnormal_embryogenesis/_devel0.97581079
69MP0005380_embryogenesis_phenotype0.97581079
70MP0002272_abnormal_nervous_system0.96729936
71MP0001293_anophthalmia0.95052840
72MP0003937_abnormal_limbs/digits/tail_de0.90957969
73MP0009053_abnormal_anal_canal0.89960130
74MP0002067_abnormal_sensory_capabilities0.87665096
75MP0006138_congestive_heart_failure0.86913717
76MP0009745_abnormal_behavioral_response0.86531643
77MP0002233_abnormal_nose_morphology0.86411623
78MP0002064_seizures0.86008947
79MP0002084_abnormal_developmental_patter0.85699954
80MP0002095_abnormal_skin_pigmentation0.83056971
81MP0002085_abnormal_embryonic_tissue0.82915622
82MP0002088_abnormal_embryonic_growth/wei0.82797419
83MP0005195_abnormal_posterior_eye0.81340418
84MP0002210_abnormal_sex_determination0.80439350
85MP0003861_abnormal_nervous_system0.79601152
86MP0003698_abnormal_male_reproductive0.79174221
87MP0005395_other_phenotype0.78247112
88MP0001915_intracranial_hemorrhage0.77608586
89MP0005248_abnormal_Harderian_gland0.76968615
90MP0001697_abnormal_embryo_size0.75854117
91MP0003984_embryonic_growth_retardation0.75670908
92MP0002102_abnormal_ear_morphology0.75463889
93MP0002090_abnormal_vision0.75037173
94MP0001177_atelectasis0.73446377
95MP0000538_abnormal_urinary_bladder0.71859295
96MP0002733_abnormal_thermal_nociception0.70836295
97MP0009672_abnormal_birth_weight0.70745614
98MP0001963_abnormal_hearing_physiology0.67666435
99MP0005391_vision/eye_phenotype0.67463161
100MP0004142_abnormal_muscle_tone0.67366887

Predicted human phenotypes

RankGene SetZ-score
1Rectovaginal fistula (HP:0000143)4.94882436
2Rectal fistula (HP:0100590)4.94882436
3Vaginal fistula (HP:0004320)4.27861458
4Intestinal fistula (HP:0100819)4.10172732
5Septate vagina (HP:0001153)4.02168972
6Methylmalonic acidemia (HP:0002912)4.00928902
7Abnormality of homocysteine metabolism (HP:0010919)3.89352724
8Homocystinuria (HP:0002156)3.89352724
9Volvulus (HP:0002580)3.61226614
10Hyperlipoproteinemia (HP:0010980)3.51800827
11Abnormality of methionine metabolism (HP:0010901)3.29486980
12Abnormal hair whorl (HP:0010721)3.16937430
13Hyperglycinemia (HP:0002154)3.10911352
14Methylmalonic aciduria (HP:0012120)3.08013331
15Fair hair (HP:0002286)3.07288876
16Abnormality of aspartate family amino acid metabolism (HP:0010899)3.01510433
17Hyperglycinuria (HP:0003108)2.98426290
18Horizontal nystagmus (HP:0000666)2.97791995
19Abnormality of serum amino acid levels (HP:0003112)2.92880479
20Abnormality of glycine metabolism (HP:0010895)2.80581133
21Abnormality of serine family amino acid metabolism (HP:0010894)2.80581133
22Atonic seizures (HP:0010819)2.77377478
23Hypoproteinemia (HP:0003075)2.73353783
24Pendular nystagmus (HP:0012043)2.67603383
25Abnormality of the vitamin B12 metabolism (HP:0004341)2.64526433
26Ependymoma (HP:0002888)2.63870861
27Attenuation of retinal blood vessels (HP:0007843)2.62055761
28Abnormality of alanine metabolism (HP:0010916)2.56975265
29Hyperalaninemia (HP:0003348)2.56975265
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56975265
31Colon cancer (HP:0003003)2.56084913
32Acute necrotizing encephalopathy (HP:0006965)2.49011439
33Glioma (HP:0009733)2.48277573
34Abolished electroretinogram (ERG) (HP:0000550)2.47961191
35Pancreatic cysts (HP:0001737)2.47417523
36Hypochromic microcytic anemia (HP:0004840)2.45991924
37Acute encephalopathy (HP:0006846)2.44993805
38Abnormality of vitamin B metabolism (HP:0004340)2.43774905
39Abnormality of the labia minora (HP:0012880)2.43237537
40Intestinal atresia (HP:0011100)2.43042301
41Papillary thyroid carcinoma (HP:0002895)2.41727881
42Clitoromegaly (HP:0000057)2.41131866
43Chorioretinal atrophy (HP:0000533)2.40755778
44Skull defect (HP:0001362)2.39866741
45Medial flaring of the eyebrow (HP:0010747)2.37272582
46Astrocytoma (HP:0009592)2.34627396
47Abnormality of the astrocytes (HP:0100707)2.34627396
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.32976183
49Bony spicule pigmentary retinopathy (HP:0007737)2.30802572
50True hermaphroditism (HP:0010459)2.30603404
51Dialeptic seizures (HP:0011146)2.25690946
52Aplasia cutis congenita (HP:0001057)2.16012348
53Progressive macrocephaly (HP:0004481)2.14952400
54Pancreatic fibrosis (HP:0100732)2.12945073
55Gait imbalance (HP:0002141)2.12298332
563-Methylglutaconic aciduria (HP:0003535)2.11742787
57Congenital sensorineural hearing impairment (HP:0008527)2.10485281
58Congenital primary aphakia (HP:0007707)2.09507305
59Urinary urgency (HP:0000012)2.05433210
60Renal hypoplasia (HP:0000089)2.03370439
61Abnormal mitochondria in muscle tissue (HP:0008316)2.01724151
62Abnormality of sulfur amino acid metabolism (HP:0004339)1.97246565
63Abnormality of the clitoris (HP:0000056)1.94848315
64Generalized hypopigmentation of hair (HP:0011358)1.94385313
65Sloping forehead (HP:0000340)1.93732311
66Dynein arm defect of respiratory motile cilia (HP:0012255)1.92067650
67Absent/shortened dynein arms (HP:0200106)1.92067650
68Febrile seizures (HP:0002373)1.90217192
69Patellar aplasia (HP:0006443)1.89288776
70Vaginal atresia (HP:0000148)1.88971657
71Ectopic kidney (HP:0000086)1.87208636
72Keratoconus (HP:0000563)1.86272877
73Increased corneal curvature (HP:0100692)1.86272877
74Abnormality of lateral ventricle (HP:0030047)1.86005311
75Thyroid carcinoma (HP:0002890)1.85203665
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.84882786
77Genital tract atresia (HP:0001827)1.84193656
78Patchy hypopigmentation of hair (HP:0011365)1.83656050
79Increased CSF lactate (HP:0002490)1.81515147
80Hepatoblastoma (HP:0002884)1.81486968
81Absence seizures (HP:0002121)1.81334040
82Protruding tongue (HP:0010808)1.80566501
83Drooling (HP:0002307)1.77574099
84Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77350288
85Molar tooth sign on MRI (HP:0002419)1.75462913
86Abnormality of midbrain morphology (HP:0002418)1.75462913
87Abnormality of vitamin metabolism (HP:0100508)1.74497147
88Chromsome breakage (HP:0040012)1.73337203
89Leukodystrophy (HP:0002415)1.72977456
90Epidermoid cyst (HP:0200040)1.72328631
91Aplasia/Hypoplasia of the patella (HP:0006498)1.72075159
92Rhabdomyosarcoma (HP:0002859)1.71889295
93Nephrogenic diabetes insipidus (HP:0009806)1.70468077
94Limb hypertonia (HP:0002509)1.69798238
95Anal atresia (HP:0002023)1.68592296
96Broad foot (HP:0001769)1.67826875
97Medulloblastoma (HP:0002885)1.67365958
98Lissencephaly (HP:0001339)1.66888587
99Gonadotropin excess (HP:0000837)1.66854576
100Shawl scrotum (HP:0000049)1.65425393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.53305575
2PDK24.26533854
3FRK4.05462426
4ACVR1B3.00438247
5MAP4K22.89560657
6BUB12.63724875
7MAPK132.36591776
8EPHA42.31094370
9SRPK12.28769689
10MKNK12.26708292
11CDC72.05714116
12MKNK22.02395733
13PBK1.98379473
14TRIM281.94761813
15TTK1.82101065
16WNK31.81985107
17BCR1.63297686
18STK38L1.63111222
19PLK41.59887142
20NEK61.55122644
21FER1.54620506
22PLK31.53568866
23TSSK61.52293542
24CASK1.45477281
25PLK21.44009883
26MAP3K41.43666443
27PAK31.40001812
28PKN11.37022548
29ZAK1.32352690
30WEE11.32284027
31GRK11.31976082
32DYRK31.29280866
33PLK11.21502688
34BMPR1B1.20155885
35STK161.19723020
36TEC1.15358730
37CSNK1G21.13847037
38MARK11.12495687
39MST41.07815377
40MAP2K71.07766684
41CSNK1G11.07053819
42RPS6KA41.06666050
43CSNK1G31.05223062
44PIK3CA0.95642696
45OXSR10.94144000
46VRK10.92709050
47CHEK20.91905178
48PRKCE0.91437418
49BRD40.90639632
50ERBB30.89881386
51BRSK20.89488451
52NUAK10.89458000
53CSNK1A1L0.88082209
54NEK10.88049256
55EPHA30.87109931
56CDK30.82728989
57CDK190.81998378
58AURKB0.79159583
59DYRK20.73202348
60PRKCI0.65671124
61ERBB20.64996826
62VRK20.61470182
63ATR0.61032319
64ADRBK20.60883308
65STK40.60590505
66IRAK10.59056078
67BCKDK0.58447411
68UHMK10.56418696
69DYRK1A0.53849928
70PRKCG0.52902612
71PNCK0.51932310
72CAMK2A0.49860153
73PINK10.48856643
74ATM0.48370135
75PRKACB0.47503077
76CSNK1A10.46365924
77CAMK40.46109060
78RPS6KA50.44935738
79CSNK2A10.44817265
80EGFR0.43747591
81NEK20.43039795
82MATK0.34635155
83CAMK10.34468545
84MAPKAPK50.34074397
85CDK10.34024338
86CHEK10.33484820
87INSRR0.32929021
88FGFR10.32695919
89PRKACA0.32346940
90PRKDC0.31550808
91TLK10.30706037
92STK390.30289770
93CDK20.27232237
94PTK2B0.26791543
95EIF2AK10.26783581
96FLT30.26101677
97FGR0.25374770
98MARK30.23966729
99GSK3B0.23299380
100EIF2AK30.22420762

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.27660477
2Protein export_Homo sapiens_hsa030602.78841613
3Homologous recombination_Homo sapiens_hsa034402.58634597
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.42378359
5Proteasome_Homo sapiens_hsa030502.41441673
6Selenocompound metabolism_Homo sapiens_hsa004502.30383796
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19771907
8Tryptophan metabolism_Homo sapiens_hsa003802.16730220
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13103764
10Propanoate metabolism_Homo sapiens_hsa006402.06954476
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06065897
12Fanconi anemia pathway_Homo sapiens_hsa034602.01089620
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98804656
14Mismatch repair_Homo sapiens_hsa034301.93739784
15Basal transcription factors_Homo sapiens_hsa030221.80784222
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80384612
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80064396
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.79032409
19RNA polymerase_Homo sapiens_hsa030201.78856486
20Nicotine addiction_Homo sapiens_hsa050331.78807943
21Oxidative phosphorylation_Homo sapiens_hsa001901.78034340
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72526637
23RNA degradation_Homo sapiens_hsa030181.70649877
24Fatty acid elongation_Homo sapiens_hsa000621.67894831
25Butanoate metabolism_Homo sapiens_hsa006501.65481208
26RNA transport_Homo sapiens_hsa030131.64009783
27Collecting duct acid secretion_Homo sapiens_hsa049661.61304757
28Pyruvate metabolism_Homo sapiens_hsa006201.58383694
29Phototransduction_Homo sapiens_hsa047441.57917818
30Steroid biosynthesis_Homo sapiens_hsa001001.49911889
31Parkinsons disease_Homo sapiens_hsa050121.44257638
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41208861
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40808758
34One carbon pool by folate_Homo sapiens_hsa006701.38518659
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37141868
36beta-Alanine metabolism_Homo sapiens_hsa004101.35050420
37Caffeine metabolism_Homo sapiens_hsa002321.30693464
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28919028
39DNA replication_Homo sapiens_hsa030301.28000835
40Cell cycle_Homo sapiens_hsa041101.26347796
41Olfactory transduction_Homo sapiens_hsa047401.25919906
42Base excision repair_Homo sapiens_hsa034101.22911299
43Peroxisome_Homo sapiens_hsa041461.18645406
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18439805
45Nucleotide excision repair_Homo sapiens_hsa034201.15505975
46mRNA surveillance pathway_Homo sapiens_hsa030151.14340761
47Spliceosome_Homo sapiens_hsa030401.11014725
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09842413
49Oocyte meiosis_Homo sapiens_hsa041141.09142504
50Fatty acid metabolism_Homo sapiens_hsa012121.08350215
51Huntingtons disease_Homo sapiens_hsa050161.02950746
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97875485
53Arginine and proline metabolism_Homo sapiens_hsa003300.97634766
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96769851
55Linoleic acid metabolism_Homo sapiens_hsa005910.93311006
56Purine metabolism_Homo sapiens_hsa002300.92343722
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91004862
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90024519
59Taste transduction_Homo sapiens_hsa047420.85592988
60Glycerolipid metabolism_Homo sapiens_hsa005610.84343674
61Pyrimidine metabolism_Homo sapiens_hsa002400.83667277
62Lysine degradation_Homo sapiens_hsa003100.82070917
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.81320411
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80822816
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73969332
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72713217
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72100059
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68339050
69Metabolic pathways_Homo sapiens_hsa011000.68159793
70Nitrogen metabolism_Homo sapiens_hsa009100.64894059
71p53 signaling pathway_Homo sapiens_hsa041150.63927003
72Alzheimers disease_Homo sapiens_hsa050100.63429420
73Sulfur metabolism_Homo sapiens_hsa009200.62012601
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.61416494
75Fatty acid degradation_Homo sapiens_hsa000710.59952829
76Ether lipid metabolism_Homo sapiens_hsa005650.58811045
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57413165
78GABAergic synapse_Homo sapiens_hsa047270.57225227
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54875713
80Retinol metabolism_Homo sapiens_hsa008300.52527882
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51994249
82Biosynthesis of amino acids_Homo sapiens_hsa012300.50169728
83Glutathione metabolism_Homo sapiens_hsa004800.48309544
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46341240
85ABC transporters_Homo sapiens_hsa020100.41909097
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41649377
87Arachidonic acid metabolism_Homo sapiens_hsa005900.40979340
88Histidine metabolism_Homo sapiens_hsa003400.38715945
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37124247
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35973433
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35287936
92Morphine addiction_Homo sapiens_hsa050320.33389714
93Vitamin digestion and absorption_Homo sapiens_hsa049770.31703317
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.31356264
95Glutamatergic synapse_Homo sapiens_hsa047240.29515637
96Starch and sucrose metabolism_Homo sapiens_hsa005000.29167659
97Sphingolipid metabolism_Homo sapiens_hsa006000.28363777
98Regulation of autophagy_Homo sapiens_hsa041400.28240304
99Notch signaling pathway_Homo sapiens_hsa043300.26997192
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26030614

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