TET3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)5.14334917
2negative regulation of erythrocyte differentiation (GO:0045647)4.12280621
3regulation of NFAT protein import into nucleus (GO:0051532)4.01925253
4response to muramyl dipeptide (GO:0032495)3.96874279
5positive regulation by symbiont of host defense response (GO:0052509)3.95295798
6modulation by symbiont of host defense response (GO:0052031)3.95295798
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.95295798
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.95295798
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.95295798
10modulation by symbiont of host immune response (GO:0052553)3.95295798
11response to peptidoglycan (GO:0032494)3.89853767
12detection of other organism (GO:0098543)3.78018456
13regulation of RNA export from nucleus (GO:0046831)3.65088338
14positive regulation of humoral immune response (GO:0002922)3.64529777
15detection of bacterium (GO:0016045)3.58289817
16histone H3-K36 demethylation (GO:0070544)3.39579704
17* histone H3-K4 methylation (GO:0051568)3.37398285
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22018494
19* histone H3-K4 trimethylation (GO:0080182)3.21361544
20regulation of B cell receptor signaling pathway (GO:0050855)3.16074470
21cellular extravasation (GO:0045123)3.14646697
22detection of external biotic stimulus (GO:0098581)3.12627919
23macrophage activation involved in immune response (GO:0002281)3.11211222
24nuclear pore complex assembly (GO:0051292)3.10500589
25detection of molecule of bacterial origin (GO:0032490)3.09257398
26regulation of nucleobase-containing compound transport (GO:0032239)3.09251726
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08414795
28negative regulation of cell killing (GO:0031342)3.08414795
29mitotic sister chromatid cohesion (GO:0007064)3.07498959
30interkinetic nuclear migration (GO:0022027)3.01738931
31oocyte development (GO:0048599)2.99992796
32regulation of histone H3-K9 methylation (GO:0051570)2.99617949
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99493343
34negative regulation of translation, ncRNA-mediated (GO:0040033)2.99493343
35regulation of translation, ncRNA-mediated (GO:0045974)2.99493343
36embryonic process involved in female pregnancy (GO:0060136)2.98075831
373-UTR-mediated mRNA stabilization (GO:0070935)2.96723268
38positive thymic T cell selection (GO:0045059)2.94256620
39phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.91539870
40regulation of chromatin binding (GO:0035561)2.89055517
41* histone lysine methylation (GO:0034968)2.86471238
42N-terminal protein amino acid acetylation (GO:0006474)2.85205203
43detection of biotic stimulus (GO:0009595)2.80524764
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80422517
45response to host immune response (GO:0052572)2.80422517
46positive T cell selection (GO:0043368)2.79167330
47B cell receptor signaling pathway (GO:0050853)2.78673908
48positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.77943113
49regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.77943113
50intracellular estrogen receptor signaling pathway (GO:0030520)2.76922351
51establishment of nucleus localization (GO:0040023)2.76443469
52immunoglobulin mediated immune response (GO:0016064)2.75896462
53response to host (GO:0075136)2.73676813
54response to host defenses (GO:0052200)2.73676813
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.73676813
56positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.72311061
57regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.72311061
58mRNA stabilization (GO:0048255)2.71814685
59RNA stabilization (GO:0043489)2.71814685
60regulation of hypersensitivity (GO:0002883)2.69715459
61positive regulation of gamma-delta T cell activation (GO:0046645)2.69392875
62germinal center formation (GO:0002467)2.69271259
63positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68854839
64epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67413348
65regulation of female gonad development (GO:2000194)2.66369060
66nucleus localization (GO:0051647)2.66246796
67regulation of DNA methylation (GO:0044030)2.64799045
68positive regulation of gene expression, epigenetic (GO:0045815)2.63649210
69protein kinase C signaling (GO:0070528)2.63462711
70negative regulation of histone modification (GO:0031057)2.61057205
71histone lysine demethylation (GO:0070076)2.60953918
72neutrophil activation involved in immune response (GO:0002283)2.58797932
73thymic T cell selection (GO:0045061)2.57893708
74regulation of interferon-beta biosynthetic process (GO:0045357)2.57205319
75negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55005757
76leukocyte aggregation (GO:0070486)2.53489028
77megakaryocyte development (GO:0035855)2.53333297
78nuclear pore organization (GO:0006999)2.53007835
79* peptidyl-lysine trimethylation (GO:0018023)2.52609728
80embryonic camera-type eye morphogenesis (GO:0048596)2.52577853
81embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51974297
82response to laminar fluid shear stress (GO:0034616)2.49864752
83regulation of leukocyte degranulation (GO:0043300)2.49753327
84corticosteroid receptor signaling pathway (GO:0031958)2.49238872
85negative T cell selection (GO:0043383)2.48979183
86regulation of mast cell degranulation (GO:0043304)2.48382723
87regulation of acrosome reaction (GO:0060046)2.48192870
88glucocorticoid receptor signaling pathway (GO:0042921)2.48181293
89positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.46905247
90negative regulation of glial cell proliferation (GO:0060253)2.46756663
91positive regulation of interleukin-4 production (GO:0032753)2.46647363
92negative regulation of T cell mediated immunity (GO:0002710)2.46085309
93dosage compensation (GO:0007549)2.45853326
94histone H3-K9 methylation (GO:0051567)2.45327445
95positive regulation of B cell differentiation (GO:0045579)2.44680043
96negative thymic T cell selection (GO:0045060)2.44210182
97neutrophil mediated immunity (GO:0002446)2.43821684
98T cell selection (GO:0045058)2.43445259
99somatic stem cell division (GO:0048103)2.43136334
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.42995306
101histone demethylation (GO:0016577)2.42464835
102negative regulation of lymphocyte mediated immunity (GO:0002707)2.39530625
103regulation of sister chromatid cohesion (GO:0007063)2.39469112
104regulation of clathrin-mediated endocytosis (GO:2000369)2.37872895
105mitotic chromosome condensation (GO:0007076)2.31207972
106negative regulation of histone methylation (GO:0031061)2.29901660
107positive regulation of granulocyte differentiation (GO:0030854)2.28417713
108positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.26457092
109regulation of ARF protein signal transduction (GO:0032012)2.23817920
110histone H3-K9 modification (GO:0061647)2.23479124
111layer formation in cerebral cortex (GO:0021819)2.22422931
112positive regulation of mRNA catabolic process (GO:0061014)2.20281499
113semaphorin-plexin signaling pathway (GO:0071526)2.19083524
114negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.18172908
115protein demethylation (GO:0006482)2.17885647
116protein dealkylation (GO:0008214)2.17885647
117filopodium assembly (GO:0046847)2.17214559
118female gamete generation (GO:0007292)2.15703617
119positive regulation of histone deacetylation (GO:0031065)2.15304008
120histone H3-K9 demethylation (GO:0033169)2.13605798
121DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.12272518
122face morphogenesis (GO:0060325)2.11844362
123eye photoreceptor cell differentiation (GO:0001754)2.10288452
124photoreceptor cell differentiation (GO:0046530)2.10288452
125* histone methylation (GO:0016571)2.10057111
126coronary vasculature morphogenesis (GO:0060977)2.10021312
127stress granule assembly (GO:0034063)2.09958950
128positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.09245417
129negative regulation of circadian rhythm (GO:0042754)2.07796844
130protein localization to endosome (GO:0036010)2.07325789
131regulation of mRNA catabolic process (GO:0061013)2.07268046
132monoubiquitinated protein deubiquitination (GO:0035520)2.07087696
133pre-miRNA processing (GO:0031054)2.07009827
134heart morphogenesis (GO:0003007)2.06873871
135establishment of spindle localization (GO:0051293)2.06519082
136peptidyl-threonine phosphorylation (GO:0018107)2.06088983
137regulation of gamma-delta T cell activation (GO:0046643)2.05662770
138regulation of histone H3-K27 methylation (GO:0061085)2.05329048
139type B pancreatic cell development (GO:0003323)2.04477380
140axon extension involved in axon guidance (GO:0048846)2.03364477
141neuron projection extension involved in neuron projection guidance (GO:1902284)2.03364477
142regulation of granulocyte differentiation (GO:0030852)2.00820090
143retrograde transport, vesicle recycling within Golgi (GO:0000301)1.98919485
144microtubule nucleation (GO:0007020)1.97142972
145cerebellar Purkinje cell differentiation (GO:0021702)1.97031565
146dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.95895798
147histone H2A monoubiquitination (GO:0035518)1.95561319
148regulation of gamma-delta T cell differentiation (GO:0045586)1.94689318
149regulation of somitogenesis (GO:0014807)1.93727885
150positive regulation of Rac GTPase activity (GO:0032855)1.92762489
151NLS-bearing protein import into nucleus (GO:0006607)1.92300032
152positive regulation of microtubule polymerization (GO:0031116)1.92160095
153lens morphogenesis in camera-type eye (GO:0002089)1.92141671
154lamellipodium organization (GO:0097581)1.92120377
155regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)1.88684472
156peptidyl-threonine modification (GO:0018210)1.88448061
157negative regulation of granulocyte differentiation (GO:0030853)1.87933565
158histone deubiquitination (GO:0016578)1.87728184
159insulin-like growth factor receptor signaling pathway (GO:0048009)1.87715023
160B cell homeostasis (GO:0001782)1.87655727
161regulation of transforming growth factor beta2 production (GO:0032909)1.87327576
162centrosome localization (GO:0051642)1.87160375
163activated T cell proliferation (GO:0050798)1.86695697
164regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.86349029
165embryonic hemopoiesis (GO:0035162)1.85152353
166regulation of histone deacetylation (GO:0031063)1.84262241
167establishment of spindle orientation (GO:0051294)1.83161727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03548891
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79047753
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62665733
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59359038
5GATA1_22025678_ChIP-Seq_K562_Human2.52325260
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47906444
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29805807
8E2F7_22180533_ChIP-Seq_HELA_Human2.20510555
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20464695
10EZH2_22144423_ChIP-Seq_EOC_Human2.15279340
11MAF_26560356_Chip-Seq_TH1_Human2.08038296
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.04145759
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01431559
14TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.99705957
15SMAD_19615063_ChIP-ChIP_OVARY_Human1.95688132
16FOXM1_23109430_ChIP-Seq_U2OS_Human1.90458131
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90049077
18GATA1_19941826_ChIP-Seq_K562_Human1.84139405
19AR_21572438_ChIP-Seq_LNCaP_Human1.81525783
20BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78795647
21MYB_26560356_Chip-Seq_TH1_Human1.77080767
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74169454
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72505099
24GATA1_19941827_ChIP-Seq_MEL_Mouse1.71375220
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.71156374
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.70998595
27MYB_26560356_Chip-Seq_TH2_Human1.68018002
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62000159
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61977486
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61835495
31* TCF7_22412390_ChIP-Seq_EML_Mouse1.59022148
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.57593256
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.57164457
34KDM2B_26808549_Chip-Seq_DND41_Human1.56454565
35RUNX_20019798_ChIP-Seq_JUKART_Human1.56302490
36* KDM2B_26808549_Chip-Seq_JURKAT_Human1.55277450
37* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54701730
38* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54641059
39* KDM2B_26808549_Chip-Seq_K562_Human1.54069541
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52492762
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52286859
42FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.50387224
43SPI1_23547873_ChIP-Seq_NB4_Human1.49332358
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47723333
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46699399
46AHR_22903824_ChIP-Seq_MCF-7_Human1.45338991
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43866327
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42624990
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.42079885
50DROSHA_22980978_ChIP-Seq_HELA_Human1.41704246
51* GATA2_19941826_ChIP-Seq_K562_Human1.40701719
52TP53_16413492_ChIP-PET_HCT116_Human1.40434970
53SCL_19346495_ChIP-Seq_HPC-7_Human1.38826343
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.38187109
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38134680
56MYC_22102868_ChIP-Seq_BL_Human1.37905905
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.37586289
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37072049
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.36061374
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35938715
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35188447
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.35067082
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33713979
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32769477
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32769477
66MAF_26560356_Chip-Seq_TH2_Human1.31843748
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31778937
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.31706735
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31421302
70NCOR1_26117541_ChIP-Seq_K562_Human1.30204341
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30199564
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.28470751
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28178601
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.25310314
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25250393
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25250393
77PU_27001747_Chip-Seq_BMDM_Mouse1.25139047
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24621746
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22878157
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22818251
81* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22803666
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22483254
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21488028
84VDR_24787735_ChIP-Seq_THP-1_Human1.19980480
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19703722
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16657168
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.15475050
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15047032
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14484326
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.14468467
91* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14180695
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13651065
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12059332
94* GATA3_27048872_Chip-Seq_THYMUS_Human1.11921769
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11138350
96STAT3_23295773_ChIP-Seq_U87_Human1.10387380
97GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09520705
98* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09355856
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.08798088
100AR_19668381_ChIP-Seq_PC3_Human1.06588014
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06574352
102CIITA_25753668_ChIP-Seq_RAJI_Human1.05984188
103SPI1_23127762_ChIP-Seq_K562_Human1.05735981
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05607040
105VDR_21846776_ChIP-Seq_THP-1_Human1.05348057
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05015244
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04909239
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03599484
109GBX2_23144817_ChIP-Seq_PC3_Human1.03428024
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02907569
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02863974
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02548047
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.01336929
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.00559721
115BP1_19119308_ChIP-ChIP_Hs578T_Human1.00311047
116RXR_22108803_ChIP-Seq_LS180_Human1.00281272
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99170324
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99155059
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98864949
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98779211
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98779211
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98779211
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98331560
124RACK7_27058665_Chip-Seq_MCF-7_Human0.97884011
125UTX_26944678_Chip-Seq_JUKART_Human0.97373799
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96917987
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96875403
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96825721
129MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96384620
130TBL1_22424771_ChIP-Seq_293T_Human0.96353120
131SMAD4_21799915_ChIP-Seq_A2780_Human0.95930067
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.95142535
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94619815
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93793941
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92852482
136GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92471579
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91830196
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91423301
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.91201118
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90068355
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89733098
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89706844
143LXR_22292898_ChIP-Seq_THP-1_Human0.89691663
144TCF4_23295773_ChIP-Seq_U87_Human0.89626259
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.89271287
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.88954301
147SMAD3_21741376_ChIP-Seq_EPCs_Human0.88420912
148JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88126838
149VDR_24763502_ChIP-Seq_THP-1_Human0.87462863
150SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87282666
151SOX2_21211035_ChIP-Seq_LN229_Gbm0.87134981
152SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87087480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.18110542
2MP0003787_abnormal_imprinting3.81511156
3MP0008057_abnormal_DNA_replication3.33493961
4MP0003436_decreased_susceptibility_to2.69262002
5MP0000383_abnormal_hair_follicle2.34424082
6MP0003656_abnormal_erythrocyte_physiolo2.33145407
7MP0005076_abnormal_cell_differentiation2.29350871
8MP0008260_abnormal_autophagy2.15153958
9MP0008961_abnormal_basal_metabolism2.10200259
10MP0002796_impaired_skin_barrier2.08867273
11MP0010678_abnormal_skin_adnexa2.05993940
12MP0001835_abnormal_antigen_presentation2.04352185
13MP0000685_abnormal_immune_system2.03994262
14MP0003121_genomic_imprinting1.96925215
15MP0000579_abnormal_nail_morphology1.83694326
16MP0002419_abnormal_innate_immunity1.77299188
17MP0003763_abnormal_thymus_physiology1.76219348
18MP0003172_abnormal_lysosome_physiology1.75644209
19MP0001851_eye_inflammation1.72995499
20MP0003300_gastrointestinal_ulcer1.69581334
21MP0002396_abnormal_hematopoietic_system1.63504656
22MP0001819_abnormal_immune_cell1.62340140
23MP0005025_abnormal_response_to1.60083270
24MP0005000_abnormal_immune_tolerance1.58937930
25MP0005174_abnormal_tail_pigmentation1.58692497
26MP0004185_abnormal_adipocyte_glucose1.56860073
27MP0009278_abnormal_bone_marrow1.56244621
28MP0005671_abnormal_response_to1.55624310
29MP0000465_gastrointestinal_hemorrhage1.53591964
30MP0002723_abnormal_immune_serum1.51811378
31MP0010234_abnormal_vibrissa_follicle1.50802518
32MP0002722_abnormal_immune_system1.49010570
33MP0000733_abnormal_muscle_development1.48181947
34MP0000015_abnormal_ear_pigmentation1.46908087
35MP0003828_pulmonary_edema1.46674043
36MP0003724_increased_susceptibility_to1.45839938
37MP0004510_myositis1.43695241
38MP0000716_abnormal_immune_system1.43278491
39MP0005551_abnormal_eye_electrophysiolog1.37594643
40MP0003303_peritoneal_inflammation1.37303482
41MP0002405_respiratory_system_inflammati1.36522187
42MP0002098_abnormal_vibrissa_morphology1.35047444
43MP0010307_abnormal_tumor_latency1.34138992
44MP0000689_abnormal_spleen_morphology1.33273471
45MP0001915_intracranial_hemorrhage1.31250208
46MP0002102_abnormal_ear_morphology1.30586642
47MP0002166_altered_tumor_susceptibility1.30509969
48MP0003935_abnormal_craniofacial_develop1.29547472
49MP0000566_synostosis1.27583517
50MP0000778_abnormal_nervous_system1.26266235
51MP0003045_fibrosis1.23215001
52MP0005409_darkened_coat_color1.22639122
53MP0003091_abnormal_cell_migration1.22261751
54MP0005501_abnormal_skin_physiology1.21372992
55MP0002429_abnormal_blood_cell1.21032316
56MP0004381_abnormal_hair_follicle1.21023024
57MP0002877_abnormal_melanocyte_morpholog1.19840225
58MP0005451_abnormal_body_composition1.19599617
59MP0005621_abnormal_cell_physiology1.19242594
60MP0008877_abnormal_DNA_methylation1.19216464
61MP0003221_abnormal_cardiomyocyte_apopto1.16384193
62MP0005248_abnormal_Harderian_gland1.13442484
63MP0001849_ear_inflammation1.13245530
64MP0002006_tumorigenesis1.12267873
65MP0002009_preneoplasia1.12144089
66MP0006072_abnormal_retinal_apoptosis1.11677119
67MP0004808_abnormal_hematopoietic_stem1.08486218
68MP0001730_embryonic_growth_arrest1.07567119
69MP0000377_abnormal_hair_follicle1.07367846
70MP0003191_abnormal_cellular_cholesterol1.07020646
71MP0003755_abnormal_palate_morphology1.06710074
72MP0003077_abnormal_cell_cycle1.06152582
73MP0003183_abnormal_peptide_metabolism1.05943269
74MP0010352_gastrointestinal_tract_polyps1.05624366
75MP0004264_abnormal_extraembryonic_tissu1.02630276
76MP0004947_skin_inflammation1.02484783
77MP0003705_abnormal_hypodermis_morpholog1.02333752
78MP0003950_abnormal_plasma_membrane1.00349510
79MP0000703_abnormal_thymus_morphology1.00165604
80MP0000427_abnormal_hair_cycle0.99943095
81MP0003861_abnormal_nervous_system0.99430354
82MP0010155_abnormal_intestine_physiology0.99259148
83MP0004859_abnormal_synaptic_plasticity0.97671353
84MP0005423_abnormal_somatic_nervous0.97287434
85MP0001672_abnormal_embryogenesis/_devel0.97251634
86MP0005380_embryogenesis_phenotype0.97251634
87MP0002925_abnormal_cardiovascular_devel0.97066584
88MP0000647_abnormal_sebaceous_gland0.96906291
89MP0003984_embryonic_growth_retardation0.96846903
90MP0003385_abnormal_body_wall0.96509848
91MP0000350_abnormal_cell_proliferation0.96274403
92MP0009115_abnormal_fat_cell0.95922945
93MP0005195_abnormal_posterior_eye0.95320343
94MP0003890_abnormal_embryonic-extraembry0.93948782
95MP0003115_abnormal_respiratory_system0.93820326
96MP0009333_abnormal_splenocyte_physiolog0.93782811
97MP0002088_abnormal_embryonic_growth/wei0.93466552
98MP0002138_abnormal_hepatobiliary_system0.93291129
99MP0001873_stomach_inflammation0.92938052
100MP0002998_abnormal_bone_remodeling0.92759125
101MP0002249_abnormal_larynx_morphology0.92060891
102MP0009672_abnormal_birth_weight0.91300186
103MP0003937_abnormal_limbs/digits/tail_de0.90263246
104MP0000432_abnormal_head_morphology0.90249357
105MP0000462_abnormal_digestive_system0.90155392
106MP0009931_abnormal_skin_appearance0.90046589
107MP0003566_abnormal_cell_adhesion0.89618505
108MP0000858_altered_metastatic_potential0.88507780
109MP0002116_abnormal_craniofacial_bone0.88445475
110MP0001800_abnormal_humoral_immune0.87637341
111MP0003453_abnormal_keratinocyte_physiol0.87634311
112MP0003699_abnormal_female_reproductive0.87093094
113MP0002086_abnormal_extraembryonic_tissu0.86991650
114MP0005310_abnormal_salivary_gland0.86136848
115MP0001216_abnormal_epidermal_layer0.85697603
116MP0005464_abnormal_platelet_physiology0.85336198
117MP0002177_abnormal_outer_ear0.84821677
118MP0000767_abnormal_smooth_muscle0.84782279
119MP0005187_abnormal_penis_morphology0.83398951
120MP0005253_abnormal_eye_physiology0.83359898
121MP0002398_abnormal_bone_marrow0.83114066
122MP0005257_abnormal_intraocular_pressure0.83046768
123MP0009785_altered_susceptibility_to0.82271451
124MP0001324_abnormal_eye_pigmentation0.82000904
125MP0000490_abnormal_crypts_of0.80982502
126MP0004883_abnormal_blood_vessel0.79189845
127MP0004197_abnormal_fetal_growth/weight/0.78957581
128MP0001346_abnormal_lacrimal_gland0.78680923
129MP0005384_cellular_phenotype0.78389028
130MP0000428_abnormal_craniofacial_morphol0.78019871
131MP0001784_abnormal_fluid_regulation0.76364915
132MP0005197_abnormal_uvea_morphology0.76260387
133MP0009703_decreased_birth_body0.76235868
134MP0002019_abnormal_tumor_incidence0.74951791
135MP0005394_taste/olfaction_phenotype0.74878789
136MP0005499_abnormal_olfactory_system0.74878789
137MP0002060_abnormal_skin_morphology0.73749318
138MP0003111_abnormal_nucleus_morphology0.73359741
139MP0005391_vision/eye_phenotype0.72409436
140MP0002928_abnormal_bile_duct0.72326379
141MP0002084_abnormal_developmental_patter0.71816683
142MP0002452_abnormal_antigen_presenting0.68629941
143MP0002085_abnormal_embryonic_tissue0.68516346
144MP0010368_abnormal_lymphatic_system0.67367571
145MP0001790_abnormal_immune_system0.66968155
146MP0005387_immune_system_phenotype0.66968155
147MP0001502_abnormal_circadian_rhythm0.65739015
148MP0002420_abnormal_adaptive_immunity0.64556159
149MP0005397_hematopoietic_system_phenotyp0.64315241
150MP0001545_abnormal_hematopoietic_system0.64315241
151MP0001286_abnormal_eye_development0.64116913

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.86291490
2Eczematoid dermatitis (HP:0000976)3.71575469
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.19053295
4Short 4th metacarpal (HP:0010044)3.19053295
5Increased IgE level (HP:0003212)3.14823636
6Lip pit (HP:0100267)3.10722810
7Genetic anticipation (HP:0003743)2.90545412
8Recurrent abscess formation (HP:0002722)2.86183151
9Narrow palate (HP:0000189)2.75863388
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.66607726
11Midline defect of the nose (HP:0004122)2.62427860
12Hyperacusis (HP:0010780)2.54696526
13Papillary thyroid carcinoma (HP:0002895)2.50674771
14Chorioretinal atrophy (HP:0000533)2.49700325
15Long eyelashes (HP:0000527)2.47962682
16Abnormality of macrophages (HP:0004311)2.47312729
17Congenital stationary night blindness (HP:0007642)2.41223244
18Trigonocephaly (HP:0000243)2.40298310
19Obstructive sleep apnea (HP:0002870)2.37542402
20Urethral obstruction (HP:0000796)2.35530612
21Cellulitis (HP:0100658)2.29229649
22Recurrent fungal infections (HP:0002841)2.28153838
23Mediastinal lymphadenopathy (HP:0100721)2.24960744
24Broad face (HP:0000283)2.22831031
25Flat acetabular roof (HP:0003180)2.19657850
26Spontaneous hematomas (HP:0007420)2.19633313
27Pigmentary retinal degeneration (HP:0001146)2.18874324
28Volvulus (HP:0002580)2.18028168
29Recurrent viral infections (HP:0004429)2.17831157
30Viral hepatitis (HP:0006562)2.17717959
31Abnormality of chromosome segregation (HP:0002916)2.16826608
32Abnormality of the 4th metacarpal (HP:0010012)2.16412184
33Recurrent skin infections (HP:0001581)2.16344337
34Gingivitis (HP:0000230)2.15457365
35Recurrent cutaneous fungal infections (HP:0011370)2.14019115
36Chronic mucocutaneous candidiasis (HP:0002728)2.14019115
37Bony spicule pigmentary retinopathy (HP:0007737)2.13895838
38Pendular nystagmus (HP:0012043)2.13300240
39Subacute progressive viral hepatitis (HP:0006572)2.11844083
40Ectopic kidney (HP:0000086)2.11250412
41Facial hemangioma (HP:0000329)2.09963218
42Meningitis (HP:0001287)2.08805420
43Macroorchidism (HP:0000053)2.08554152
44Osteomyelitis (HP:0002754)2.08145442
45Asymmetry of the thorax (HP:0001555)2.07485898
46Oligodontia (HP:0000677)2.07346579
47Absent frontal sinuses (HP:0002688)2.06840453
48Abnormality of the intervertebral disk (HP:0005108)2.06349680
49Supernumerary ribs (HP:0005815)2.05596400
50Acute myeloid leukemia (HP:0004808)2.05171446
51Arterial tortuosity (HP:0005116)2.00161277
52Shallow orbits (HP:0000586)2.00122098
53Colitis (HP:0002583)1.99875694
54Heterotopia (HP:0002282)1.98440747
55Gastrointestinal infarctions (HP:0005244)1.96459767
56Germ cell neoplasia (HP:0100728)1.94885512
57Milia (HP:0001056)1.94402675
58Transitional cell carcinoma of the bladder (HP:0006740)1.94046203
59Recurrent gram-negative bacterial infections (HP:0005420)1.93541775
60Optic neuritis (HP:0100653)1.92549323
61Retrobulbar optic neuritis (HP:0100654)1.92549323
62Spondylolisthesis (HP:0003302)1.90194370
63Abnormality of the nasal septum (HP:0000419)1.88282117
64Curly hair (HP:0002212)1.87135950
65Slow saccadic eye movements (HP:0000514)1.86758888
66Limited elbow extension (HP:0001377)1.85346399
67Abnormal delayed hypersensitivity skin test (HP:0002963)1.84544094
68Dysmetric saccades (HP:0000641)1.84326128
69Myositis (HP:0100614)1.83769943
70Disinhibition (HP:0000734)1.82486578
71Uterine leiomyosarcoma (HP:0002891)1.82048135
72Leiomyosarcoma (HP:0100243)1.82048135
73Ureteral obstruction (HP:0006000)1.81987418
74Acute lymphatic leukemia (HP:0006721)1.81051764
75Orchitis (HP:0100796)1.80994316
76Gastrointestinal inflammation (HP:0004386)1.80990369
77Keratoconjunctivitis sicca (HP:0001097)1.80649659
78Inappropriate behavior (HP:0000719)1.80362566
79Ureteral stenosis (HP:0000071)1.79480068
80Elfin facies (HP:0004428)1.77368440
81Abnormality of nail color (HP:0100643)1.77190041
82Urticaria (HP:0001025)1.76848605
83Long palpebral fissure (HP:0000637)1.75438557
84Sparse scalp hair (HP:0002209)1.75102163
85Aqueductal stenosis (HP:0002410)1.74828064
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.74345993
87Renal cell carcinoma (HP:0005584)1.74291007
88Vasculitis (HP:0002633)1.74271829
89Abnormality of the parietal bone (HP:0002696)1.73834067
90Thyroid carcinoma (HP:0002890)1.73816465
91Bladder neoplasm (HP:0009725)1.73435724
92Bladder carcinoma (HP:0002862)1.73435724
93High anterior hairline (HP:0009890)1.72862546
94Inflammation of the large intestine (HP:0002037)1.71496616
95Cutis marmorata (HP:0000965)1.71444685
96Renovascular hypertension (HP:0100817)1.71070818
97Supernumerary bones of the axial skeleton (HP:0009144)1.71036587
98Large earlobe (HP:0009748)1.70952136
99Deep palmar crease (HP:0006191)1.70603793
100Neonatal hypoglycemia (HP:0001998)1.70082963
101Depressed nasal tip (HP:0000437)1.69565767
102Sparse lateral eyebrow (HP:0005338)1.68500448
103Poikilocytosis (HP:0004447)1.68168709
104Anal stenosis (HP:0002025)1.67786524
105Ectropion (HP:0000656)1.66246146
106Deep philtrum (HP:0002002)1.66223620
107Malignant gastrointestinal tract tumors (HP:0006749)1.65960096
108Gastrointestinal carcinoma (HP:0002672)1.65960096
109Pustule (HP:0200039)1.65235659
110Dislocated radial head (HP:0003083)1.64044734
111Recurrent bacterial skin infections (HP:0005406)1.63574401
112Thick eyebrow (HP:0000574)1.63447922
113Disproportionate tall stature (HP:0001519)1.62760780
114Skin pits (HP:0100276)1.61135867
115Patellar dislocation (HP:0002999)1.60904684
116Aortic aneurysm (HP:0004942)1.60387120
117Truncal obesity (HP:0001956)1.60213829
118Spinal cord lesions (HP:0100561)1.59736476
119Syringomyelia (HP:0003396)1.59736476
120Tented upper lip vermilion (HP:0010804)1.59559460
121Aplasia cutis congenita (HP:0001057)1.59406024
122Abnormality of the radial head (HP:0003995)1.58445746
123Vascular tortuosity (HP:0004948)1.58362895
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57697275
125Oligodactyly (HP:0012165)1.57213386
126Arterial thrombosis (HP:0004420)1.57024878
127Hypoplastic labia majora (HP:0000059)1.56588214
128Widely spaced teeth (HP:0000687)1.56176351
129Hypoplasia of the maxilla (HP:0000327)1.55614148
130Cerebral aneurysm (HP:0004944)1.55333974
131Low anterior hairline (HP:0000294)1.55304094
132Autoimmune thrombocytopenia (HP:0001973)1.54792697
133Vertebral arch anomaly (HP:0008438)1.53934269
134Hypochromic microcytic anemia (HP:0004840)1.53625956
135Excessive salivation (HP:0003781)1.52403229
136Drooling (HP:0002307)1.52403229
137Sepsis (HP:0100806)1.52157729
138Overriding aorta (HP:0002623)1.51869002
139Peripheral hypomyelination (HP:0007182)1.51668592
140Obsessive-compulsive behavior (HP:0000722)1.50652310
141Metaphyseal cupping (HP:0003021)1.49607717
142Abnormal rod and cone electroretinograms (HP:0008323)1.48978216
143Chest pain (HP:0100749)1.48722333
144Neuronal loss in central nervous system (HP:0002529)1.48667130
145Fatigue (HP:0012378)1.48502036
146Thick nail (HP:0001805)1.48480749
147Abnormality of the labia majora (HP:0012881)1.47976292
148Increased nuchal translucency (HP:0010880)1.47873667
149Encephalitis (HP:0002383)1.47726944
150Vitreoretinal degeneration (HP:0000655)1.47674539
151Mitral valve prolapse (HP:0001634)1.47390343
152Abnormality of the columella (HP:0009929)1.47389329
153Chin dimple (HP:0010751)1.47178311
154Broad thumb (HP:0011304)1.46515265
155Tapered finger (HP:0001182)1.46464669
156Abnormality of incisor morphology (HP:0011063)1.46360012
157Skull defect (HP:0001362)1.45900697
158Prominent nose (HP:0000448)1.45725220
159Pointed chin (HP:0000307)1.45622602
160Thyroiditis (HP:0100646)1.44625609
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.44347542
162Sandal gap (HP:0001852)1.42955200
163Chromsome breakage (HP:0040012)1.42554878
164Short philtrum (HP:0000322)1.42222194
165Oligodactyly (hands) (HP:0001180)1.41861446
166Abnormality of macular pigmentation (HP:0008002)1.41743512
167Cortical dysplasia (HP:0002539)1.41458217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.73317831
2LATS13.91602535
3CDK123.91118984
4RIPK42.93943463
5TAOK32.79518901
6CAMK1G2.44010306
7SIK22.37091433
8EEF2K2.29634554
9CAMK1D2.08202376
10MAP3K102.00713671
11MARK21.97425620
12MAP3K61.94482436
13DMPK1.93995941
14TAOK11.92576563
15SMG11.73120639
16BRD41.72408300
17MAP3K141.66195837
18BLK1.57566543
19CDK91.55768815
20IRAK41.54917149
21MAP4K11.53144484
22MAP2K31.53038972
23STK101.47909278
24KSR21.36885394
25NTRK21.36217444
26SIK31.33924010
27STK31.33033433
28NUAK11.32696990
29RIPK11.26438908
30CLK11.25583411
31MAP3K131.23530733
32LATS21.22106078
33CSK1.19189392
34ERN11.18146332
35FGR1.17722813
36PKN21.14974761
37STK241.12898944
38FGFR41.11196906
39MELK1.08754458
40TRIB31.08660162
41CDK61.08385852
42IKBKE1.07769269
43YES11.05998097
44IRAK21.02125726
45PRKAA21.01797410
46MAP3K71.00780826
47CHUK1.00293190
48SGK20.99991006
49PDGFRB0.99210365
50ICK0.97930487
51EPHA30.97437476
52SGK30.97252015
53BTK0.96741808
54MTOR0.96302348
55FGFR30.93351411
56TAOK20.87001912
57MAP3K30.86822258
58TYRO30.86732812
59PTK60.86211216
60CDC70.85992915
61PRKD20.85837938
62SIK10.85731264
63TNK20.85450879
64EPHB10.84686800
65CDK30.82940931
66HIPK20.82489483
67HCK0.82043225
68ERBB20.81732294
69CSNK1A1L0.81089468
70SYK0.80160774
71MAPK130.79928314
72MAP3K40.79763747
73RAF10.79210771
74ZAP700.78942523
75JAK30.78503111
76JAK20.78476881
77JAK10.78134048
78BMPR20.77377226
79TYK20.76334163
80CSF1R0.76255305
81CHEK20.75966655
82GRK60.75822545
83ITK0.74441013
84FES0.74242261
85EPHB20.73153432
86NEK20.73021466
87RET0.72462844
88PIM10.72009670
89MATK0.71886501
90TTK0.71610007
91MAP3K90.71342906
92FGFR20.71253263
93RPS6KL10.71019485
94RPS6KC10.71019485
95KSR10.70907840
96IRAK10.70544345
97CAMK40.70399676
98MARK10.69870850
99MAP3K10.69817081
100CDK80.69539545
101CSNK1G20.68432661
102PAK60.67469719
103MAP3K20.65446018
104MARK30.65011851
105KIT0.64034718
106SGK10.62575399
107NEK60.61753545
108MAPK70.61637050
109PRKAA10.60990019
110PDK10.59263859
111TXK0.58993498
112PRKCH0.58483016
113SGK4940.57981581
114SGK2230.57981581
115CDK40.56689534
116MAPK100.55852020
117DYRK1A0.55518067
118RPS6KA60.54395548
119PKN10.54297592
120TRPM70.53699657
121IRAK30.53318439
122TNIK0.52430631
123CDK70.52429000
124TTN0.51444523
125STK110.51368043
126LYN0.50985152
127CSNK1D0.50939404
128PDPK10.50768078
129MAPK140.50391830
130STK380.50296741
131CSNK1G10.50160987
132ATM0.49989374
133NLK0.49246209
134GSK3B0.48586643
135TBK10.48484409
136MAPK120.48379793
137NEK90.48250680
138RPS6KA20.47854927
139ABL10.47125231
140CHEK10.46632210
141MAPK80.46488923
142AKT10.45977435
143WNK10.45632484
144RPS6KA40.45598834
145MAP3K80.44605368
146IKBKB0.43786387
147MAPK90.43553094
148PRKD10.41550364
149CDC42BPA0.40941495
150STK40.40721975
151TGFBR20.40451192
152LCK0.38955776

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03687616
2Phototransduction_Homo sapiens_hsa047441.93053658
3Lysine degradation_Homo sapiens_hsa003101.60968811
4Pancreatic cancer_Homo sapiens_hsa052121.60254503
5Notch signaling pathway_Homo sapiens_hsa043301.54601400
6Adherens junction_Homo sapiens_hsa045201.45464485
7Dorso-ventral axis formation_Homo sapiens_hsa043201.45179832
8MicroRNAs in cancer_Homo sapiens_hsa052061.43203439
9Chronic myeloid leukemia_Homo sapiens_hsa052201.41570699
10Thyroid cancer_Homo sapiens_hsa052161.39631685
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37037000
12T cell receptor signaling pathway_Homo sapiens_hsa046601.35837463
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34032214
14Colorectal cancer_Homo sapiens_hsa052101.33606473
15B cell receptor signaling pathway_Homo sapiens_hsa046621.30187722
16Axon guidance_Homo sapiens_hsa043601.29647832
17Endometrial cancer_Homo sapiens_hsa052131.28019754
18Tuberculosis_Homo sapiens_hsa051521.24983138
19Osteoclast differentiation_Homo sapiens_hsa043801.21926622
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20180899
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17388409
22Hepatitis C_Homo sapiens_hsa051601.16754197
23Ovarian steroidogenesis_Homo sapiens_hsa049131.15579964
24Non-small cell lung cancer_Homo sapiens_hsa052231.14448137
25Choline metabolism in cancer_Homo sapiens_hsa052311.13476153
26Type II diabetes mellitus_Homo sapiens_hsa049301.09344598
27Renal cell carcinoma_Homo sapiens_hsa052111.05929873
28Basal cell carcinoma_Homo sapiens_hsa052171.05780877
29Small cell lung cancer_Homo sapiens_hsa052221.04770620
30Circadian rhythm_Homo sapiens_hsa047101.04462755
31Apoptosis_Homo sapiens_hsa042101.03709560
32ErbB signaling pathway_Homo sapiens_hsa040121.03692826
33Viral myocarditis_Homo sapiens_hsa054161.03537549
34mTOR signaling pathway_Homo sapiens_hsa041501.03141067
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02288473
36GnRH signaling pathway_Homo sapiens_hsa049121.02206697
37VEGF signaling pathway_Homo sapiens_hsa043700.99532417
38Glioma_Homo sapiens_hsa052140.99195136
39Chemokine signaling pathway_Homo sapiens_hsa040620.99067212
40Viral carcinogenesis_Homo sapiens_hsa052030.97994438
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95592028
42Phospholipase D signaling pathway_Homo sapiens_hsa040720.95539067
43HIF-1 signaling pathway_Homo sapiens_hsa040660.95383351
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.95023475
45FoxO signaling pathway_Homo sapiens_hsa040680.94714258
46Prolactin signaling pathway_Homo sapiens_hsa049170.94638559
47Toxoplasmosis_Homo sapiens_hsa051450.94614878
48Platelet activation_Homo sapiens_hsa046110.93557973
49Prostate cancer_Homo sapiens_hsa052150.93108741
50Primary immunodeficiency_Homo sapiens_hsa053400.92862974
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91448965
52Acute myeloid leukemia_Homo sapiens_hsa052210.91140926
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90669351
54Wnt signaling pathway_Homo sapiens_hsa043100.90563393
55Cholinergic synapse_Homo sapiens_hsa047250.90188299
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.90036093
57cAMP signaling pathway_Homo sapiens_hsa040240.89775222
58Staphylococcus aureus infection_Homo sapiens_hsa051500.89723727
59MAPK signaling pathway_Homo sapiens_hsa040100.89453369
60TGF-beta signaling pathway_Homo sapiens_hsa043500.89311646
61Proteoglycans in cancer_Homo sapiens_hsa052050.88595487
62Glutamatergic synapse_Homo sapiens_hsa047240.88167299
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87995691
64Hepatitis B_Homo sapiens_hsa051610.87776575
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87006945
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86783095
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85692031
68Inositol phosphate metabolism_Homo sapiens_hsa005620.84617106
69Insulin signaling pathway_Homo sapiens_hsa049100.84466421
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.84458461
71Oxytocin signaling pathway_Homo sapiens_hsa049210.84385105
72Bladder cancer_Homo sapiens_hsa052190.84363094
73HTLV-I infection_Homo sapiens_hsa051660.84323484
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84164488
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83903598
76Epstein-Barr virus infection_Homo sapiens_hsa051690.83695000
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83575209
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83027641
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80991153
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.79160183
81Rap1 signaling pathway_Homo sapiens_hsa040150.78097653
82Focal adhesion_Homo sapiens_hsa045100.78007002
83Ras signaling pathway_Homo sapiens_hsa040140.77793315
84Estrogen signaling pathway_Homo sapiens_hsa049150.77273740
85Hippo signaling pathway_Homo sapiens_hsa043900.76966601
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76845233
87Pathways in cancer_Homo sapiens_hsa052000.76614077
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76336354
89Circadian entrainment_Homo sapiens_hsa047130.76195304
90Leishmaniasis_Homo sapiens_hsa051400.75982291
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75858616
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75517022
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75325926
94Long-term depression_Homo sapiens_hsa047300.74917353
95TNF signaling pathway_Homo sapiens_hsa046680.74884931
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.74880393
97mRNA surveillance pathway_Homo sapiens_hsa030150.74764989
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74081918
99Measles_Homo sapiens_hsa051620.73592743
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73508629
101Olfactory transduction_Homo sapiens_hsa047400.73445806
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.73115589
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72808305
104Herpes simplex infection_Homo sapiens_hsa051680.72394480
105Malaria_Homo sapiens_hsa051440.71911864
106Morphine addiction_Homo sapiens_hsa050320.71599386
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71082980
108Dilated cardiomyopathy_Homo sapiens_hsa054140.70886471
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70546976
110Cell cycle_Homo sapiens_hsa041100.69816670
111Long-term potentiation_Homo sapiens_hsa047200.69459233
112Legionellosis_Homo sapiens_hsa051340.69392035
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68906067
114Shigellosis_Homo sapiens_hsa051310.67978670
115Influenza A_Homo sapiens_hsa051640.67750005
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67341271
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.66676306
118Melanogenesis_Homo sapiens_hsa049160.66517795
119ECM-receptor interaction_Homo sapiens_hsa045120.65646588
120Insulin resistance_Homo sapiens_hsa049310.64619232
121Amoebiasis_Homo sapiens_hsa051460.63053647
122AMPK signaling pathway_Homo sapiens_hsa041520.62826049
123Allograft rejection_Homo sapiens_hsa053300.61481160
124Hematopoietic cell lineage_Homo sapiens_hsa046400.60660820
125Graft-versus-host disease_Homo sapiens_hsa053320.57536861
126Autoimmune thyroid disease_Homo sapiens_hsa053200.57205888
127Endocytosis_Homo sapiens_hsa041440.56335555
128Gap junction_Homo sapiens_hsa045400.55034558
129Salmonella infection_Homo sapiens_hsa051320.53187430

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