

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore organization (GO:0006999) | 4.73896529 |
| 2 | nuclear pore complex assembly (GO:0051292) | 4.55826367 |
| 3 | DNA unwinding involved in DNA replication (GO:0006268) | 4.48696069 |
| 4 | DNA replication initiation (GO:0006270) | 4.39648919 |
| 5 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.36231116 |
| 6 | mitotic metaphase plate congression (GO:0007080) | 4.19715213 |
| 7 | DNA strand elongation (GO:0022616) | 4.13477862 |
| 8 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.13427829 |
| 9 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.13427829 |
| 10 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.07393976 |
| 11 | mitotic nuclear envelope disassembly (GO:0007077) | 3.99914608 |
| 12 | protein localization to kinetochore (GO:0034501) | 3.94013693 |
| 13 | DNA replication checkpoint (GO:0000076) | 3.92695625 |
| 14 | formation of translation preinitiation complex (GO:0001731) | 3.92648004 |
| 15 | nucleobase biosynthetic process (GO:0046112) | 3.89457582 |
| 16 | metaphase plate congression (GO:0051310) | 3.87930097 |
| 17 | maturation of SSU-rRNA (GO:0030490) | 3.87809099 |
| 18 | chromatin remodeling at centromere (GO:0031055) | 3.84223663 |
| 19 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.81677614 |
| 20 | kinetochore organization (GO:0051383) | 3.81098180 |
| 21 | telomere maintenance via recombination (GO:0000722) | 3.75776829 |
| 22 | purine nucleobase biosynthetic process (GO:0009113) | 3.75444725 |
| 23 | nuclear envelope disassembly (GO:0051081) | 3.72353879 |
| 24 | membrane disassembly (GO:0030397) | 3.72353879 |
| 25 | CENP-A containing nucleosome assembly (GO:0034080) | 3.70472275 |
| 26 | mitotic recombination (GO:0006312) | 3.66233208 |
| 27 | ribosome biogenesis (GO:0042254) | 3.62584209 |
| 28 | ribosome assembly (GO:0042255) | 3.59681505 |
| 29 | pore complex assembly (GO:0046931) | 3.57391782 |
| 30 | replication fork processing (GO:0031297) | 3.56897476 |
| 31 | DNA double-strand break processing (GO:0000729) | 3.56344383 |
| 32 | IMP biosynthetic process (GO:0006188) | 3.53717376 |
| 33 | mitotic chromosome condensation (GO:0007076) | 3.53521151 |
| 34 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.53050430 |
| 35 | DNA replication-independent nucleosome organization (GO:0034724) | 3.53050430 |
| 36 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.52043262 |
| 37 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.49133658 |
| 38 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.49133658 |
| 39 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.48181489 |
| 40 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.48181489 |
| 41 | protein K6-linked ubiquitination (GO:0085020) | 3.47485093 |
| 42 | kinetochore assembly (GO:0051382) | 3.47351116 |
| 43 | protein localization to chromosome, centromeric region (GO:0071459) | 3.47285146 |
| 44 | establishment of chromosome localization (GO:0051303) | 3.43672325 |
| 45 | negative regulation of DNA recombination (GO:0045910) | 3.43342745 |
| 46 | telomere maintenance via telomere lengthening (GO:0010833) | 3.40502741 |
| 47 | DNA ligation (GO:0006266) | 3.39151285 |
| 48 | histone exchange (GO:0043486) | 3.37233462 |
| 49 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.36637992 |
| 50 | regulation of spindle organization (GO:0090224) | 3.34903785 |
| 51 | negative regulation of chromosome segregation (GO:0051985) | 3.34697450 |
| 52 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.34136606 |
| 53 | regulation of gene silencing by miRNA (GO:0060964) | 3.34136606 |
| 54 | regulation of gene silencing by RNA (GO:0060966) | 3.34136606 |
| 55 | piRNA metabolic process (GO:0034587) | 3.33026812 |
| 56 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.32943526 |
| 57 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.32943526 |
| 58 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.32943526 |
| 59 | negative regulation of sister chromatid segregation (GO:0033046) | 3.32943526 |
| 60 | regulation of helicase activity (GO:0051095) | 3.32412812 |
| 61 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.32367681 |
| 62 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.31828106 |
| 63 | ribosomal small subunit assembly (GO:0000028) | 3.31235106 |
| 64 | ribosomal large subunit biogenesis (GO:0042273) | 3.29896297 |
| 65 | regulation of centriole replication (GO:0046599) | 3.27485326 |
| 66 | spindle assembly checkpoint (GO:0071173) | 3.27359890 |
| 67 | DNA strand renaturation (GO:0000733) | 3.27185360 |
| 68 | mitotic spindle assembly checkpoint (GO:0007094) | 3.26757889 |
| 69 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.26109390 |
| 70 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.25640456 |
| 71 | non-recombinational repair (GO:0000726) | 3.25640456 |
| 72 | meiotic chromosome segregation (GO:0045132) | 3.25004304 |
| 73 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.23999662 |
| 74 | mitotic sister chromatid cohesion (GO:0007064) | 3.23308985 |
| 75 | DNA duplex unwinding (GO:0032508) | 3.22977065 |
| 76 | DNA geometric change (GO:0032392) | 3.22925087 |
| 77 | spindle checkpoint (GO:0031577) | 3.22225481 |
| 78 | pre-miRNA processing (GO:0031054) | 3.21987054 |
| 79 | mitotic spindle checkpoint (GO:0071174) | 3.19620561 |
| 80 | IMP metabolic process (GO:0046040) | 3.18709965 |
| 81 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.16904322 |
| 82 | mitotic sister chromatid segregation (GO:0000070) | 3.15898501 |
| 83 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.15080259 |
| 84 | regulation of histone H3-K9 methylation (GO:0051570) | 3.14574925 |
| 85 | response to X-ray (GO:0010165) | 3.14250206 |
| 86 | heterochromatin organization (GO:0070828) | 3.13557385 |
| 87 | regulation of chromosome segregation (GO:0051983) | 3.12604966 |
| 88 | regulation of centrosome cycle (GO:0046605) | 3.11097637 |
| 89 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.10357681 |
| 90 | mitochondrial RNA metabolic process (GO:0000959) | 3.07763846 |
| 91 | mismatch repair (GO:0006298) | 3.07539315 |
| 92 | spliceosomal snRNP assembly (GO:0000387) | 3.04800766 |
| 93 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.04399582 |
| 94 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.04399582 |
| 95 | regulation of sister chromatid segregation (GO:0033045) | 3.04399582 |
| 96 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.03414086 |
| 97 | mitotic G2/M transition checkpoint (GO:0044818) | 3.03271435 |
| 98 | rRNA processing (GO:0006364) | 3.02043874 |
| 99 | regulation of DNA endoreduplication (GO:0032875) | 2.99711324 |
| 100 | DNA topological change (GO:0006265) | 2.99048375 |
| 101 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 2.98874569 |
| 102 | chromatin assembly or disassembly (GO:0006333) | 2.97418750 |
| 103 | pseudouridine synthesis (GO:0001522) | 2.96979010 |
| 104 | DNA synthesis involved in DNA repair (GO:0000731) | 2.95828134 |
| 105 | DNA deamination (GO:0045006) | 2.95262278 |
| 106 | rRNA metabolic process (GO:0016072) | 2.95012085 |
| 107 | sister chromatid segregation (GO:0000819) | 2.94366755 |
| 108 | positive regulation of chromosome segregation (GO:0051984) | 2.93973726 |
| 109 | synaptonemal complex assembly (GO:0007130) | 2.93194286 |
| 110 | regulation of centrosome duplication (GO:0010824) | 2.92705306 |
| 111 | postreplication repair (GO:0006301) | 2.91975604 |
| 112 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 2.89207741 |
| 113 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.89129165 |
| 114 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.88268894 |
| 115 | centriole replication (GO:0007099) | 2.87316349 |
| 116 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.86044662 |
| 117 | synapsis (GO:0007129) | 2.85909248 |
| 118 | recombinational repair (GO:0000725) | 2.83940762 |
| 119 | ATP-dependent chromatin remodeling (GO:0043044) | 2.83902553 |
| 120 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.83743776 |
| 121 | isotype switching (GO:0045190) | 2.83743776 |
| 122 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.83743776 |
| 123 | establishment of integrated proviral latency (GO:0075713) | 2.83605166 |
| 124 | telomere organization (GO:0032200) | 2.83500052 |
| 125 | DNA conformation change (GO:0071103) | 2.83403410 |
| 126 | double-strand break repair via homologous recombination (GO:0000724) | 2.83347325 |
| 127 | telomere maintenance (GO:0000723) | 2.82274119 |
| 128 | nuclear envelope organization (GO:0006998) | 2.81464099 |
| 129 | maturation of 5.8S rRNA (GO:0000460) | 2.80493608 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.00637556 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.29452700 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.10447339 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.87259526 |
| 5 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.20659976 |
| 6 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.14028164 |
| 7 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.03735078 |
| 8 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.98621488 |
| 9 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.86747302 |
| 10 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.85843718 |
| 11 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.82282665 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.68526092 |
| 13 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.65090862 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.52999101 |
| 15 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.52205879 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.48839915 |
| 17 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.46803435 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.37641633 |
| 19 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.32630915 |
| 20 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.24776973 |
| 21 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.24057554 |
| 22 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.22971707 |
| 23 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.22971263 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.18572033 |
| 25 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.16761555 |
| 26 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.08892870 |
| 27 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.07197351 |
| 28 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 2.06300540 |
| 29 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.92135530 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.91219450 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.90685609 |
| 32 | EWS_26573619_Chip-Seq_HEK293_Human | 1.90498951 |
| 33 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.87887380 |
| 34 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.87214176 |
| 35 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.86032732 |
| 36 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.80307629 |
| 37 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.78569185 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.78462073 |
| 39 | FUS_26573619_Chip-Seq_HEK293_Human | 1.76087584 |
| 40 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.75772518 |
| 41 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.74543909 |
| 42 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.70699201 |
| 43 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.67099218 |
| 44 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.62434562 |
| 45 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.57711038 |
| 46 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.57161458 |
| 47 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.56889690 |
| 48 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.56620471 |
| 49 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.54815849 |
| 50 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.53421255 |
| 51 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.53289537 |
| 52 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.52484115 |
| 53 | VDR_22108803_ChIP-Seq_LS180_Human | 1.51369553 |
| 54 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.50040526 |
| 55 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.49640978 |
| 56 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.48795774 |
| 57 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.47909877 |
| 58 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.46402109 |
| 59 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.44504457 |
| 60 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.44504457 |
| 61 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.44504457 |
| 62 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.44371445 |
| 63 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.42947522 |
| 64 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42805335 |
| 65 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.42633678 |
| 66 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.42511424 |
| 67 | MYC_22102868_ChIP-Seq_BL_Human | 1.41041776 |
| 68 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.40910932 |
| 69 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.38878815 |
| 70 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.37148387 |
| 71 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.35942390 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.34807673 |
| 73 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.34523601 |
| 74 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.29289625 |
| 75 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.27685336 |
| 76 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.26751043 |
| 77 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.25748886 |
| 78 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.25612246 |
| 79 | * TFEB_21752829_ChIP-Seq_HELA_Human | 1.24695851 |
| 80 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.22833713 |
| 81 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.21735918 |
| 82 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.20031482 |
| 83 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.18998852 |
| 84 | P300_19829295_ChIP-Seq_ESCs_Human | 1.14987321 |
| 85 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.12574700 |
| 86 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.11920975 |
| 87 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.11113705 |
| 88 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.11018496 |
| 89 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.10808195 |
| 90 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.10652066 |
| 91 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.07956461 |
| 92 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.07063196 |
| 93 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06623972 |
| 94 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.06617866 |
| 95 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.05909257 |
| 96 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.01922500 |
| 97 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01655454 |
| 98 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.01513519 |
| 99 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.98696101 |
| 100 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.97493451 |
| 101 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.97465869 |
| 102 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.97345334 |
| 103 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.95362583 |
| 104 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.95247733 |
| 105 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.95061607 |
| 106 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.93967762 |
| 107 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.93544964 |
| 108 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.93147655 |
| 109 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.89215287 |
| 110 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.87611133 |
| 111 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.87589746 |
| 112 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.87365088 |
| 113 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86300167 |
| 114 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.86252822 |
| 115 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.84348985 |
| 116 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.83885099 |
| 117 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.82459081 |
| 118 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.82021480 |
| 119 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.81149061 |
| 120 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.80054470 |
| 121 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.79885069 |
| 122 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.79841669 |
| 123 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.78208373 |
| 124 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.77444982 |
| 125 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.77319121 |
| 126 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.74612171 |
| 127 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.73468510 |
| 128 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.72337568 |
| 129 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.72231318 |
| 130 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.71519958 |
| 131 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.71262696 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.99516891 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.85695850 |
| 3 | MP0008057_abnormal_DNA_replication | 4.36592829 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.24763118 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 4.17547026 |
| 6 | MP0003077_abnormal_cell_cycle | 3.97058289 |
| 7 | MP0008877_abnormal_DNA_methylation | 3.79811566 |
| 8 | MP0008058_abnormal_DNA_repair | 3.58124240 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.88074825 |
| 10 | MP0010352_gastrointestinal_tract_polyps | 2.57048374 |
| 11 | MP0003123_paternal_imprinting | 2.55439223 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.53039486 |
| 13 | MP0001730_embryonic_growth_arrest | 2.42416804 |
| 14 | MP0003786_premature_aging | 2.34292824 |
| 15 | MP0000350_abnormal_cell_proliferation | 2.30355602 |
| 16 | MP0010307_abnormal_tumor_latency | 1.99931918 |
| 17 | MP0002396_abnormal_hematopoietic_system | 1.95717793 |
| 18 | MP0009697_abnormal_copulation | 1.92478796 |
| 19 | MP0002210_abnormal_sex_determination | 1.92064051 |
| 20 | MP0001672_abnormal_embryogenesis/_devel | 1.79028045 |
| 21 | MP0005380_embryogenesis_phenotype | 1.79028045 |
| 22 | MP0001697_abnormal_embryo_size | 1.75133512 |
| 23 | MP0001929_abnormal_gametogenesis | 1.66891761 |
| 24 | MP0001145_abnormal_male_reproductive | 1.63153342 |
| 25 | MP0002102_abnormal_ear_morphology | 1.62632430 |
| 26 | MP0003984_embryonic_growth_retardation | 1.60974221 |
| 27 | MP0002085_abnormal_embryonic_tissue | 1.59767859 |
| 28 | MP0002084_abnormal_developmental_patter | 1.57934678 |
| 29 | MP0003121_genomic_imprinting | 1.57597790 |
| 30 | MP0003890_abnormal_embryonic-extraembry | 1.56875707 |
| 31 | MP0002088_abnormal_embryonic_growth/wei | 1.56744636 |
| 32 | MP0002080_prenatal_lethality | 1.52134776 |
| 33 | MP0000490_abnormal_crypts_of | 1.49680590 |
| 34 | MP0004197_abnormal_fetal_growth/weight/ | 1.49452179 |
| 35 | MP0004808_abnormal_hematopoietic_stem | 1.48748843 |
| 36 | MP0000313_abnormal_cell_death | 1.45910053 |
| 37 | MP0002086_abnormal_extraembryonic_tissu | 1.45194290 |
| 38 | MP0000653_abnormal_sex_gland | 1.41262274 |
| 39 | MP0003718_maternal_effect | 1.40112883 |
| 40 | MP0001293_anophthalmia | 1.37521417 |
| 41 | MP0006072_abnormal_retinal_apoptosis | 1.37029476 |
| 42 | MP0002697_abnormal_eye_size | 1.36158121 |
| 43 | MP0002019_abnormal_tumor_incidence | 1.36103947 |
| 44 | MP0001188_hyperpigmentation | 1.31151568 |
| 45 | MP0005076_abnormal_cell_differentiation | 1.30989071 |
| 46 | MP0003941_abnormal_skin_development | 1.29727140 |
| 47 | MP0003567_abnormal_fetal_cardiomyocyte | 1.26931015 |
| 48 | MP0006035_abnormal_mitochondrial_morpho | 1.20646885 |
| 49 | MP0001529_abnormal_vocalization | 1.20484676 |
| 50 | MP0010030_abnormal_orbit_morphology | 1.20172565 |
| 51 | MP0002233_abnormal_nose_morphology | 1.17954710 |
| 52 | MP0002160_abnormal_reproductive_system | 1.14619955 |
| 53 | MP0005397_hematopoietic_system_phenotyp | 1.13845393 |
| 54 | MP0001545_abnormal_hematopoietic_system | 1.13845393 |
| 55 | MP0002653_abnormal_ependyma_morphology | 1.13282615 |
| 56 | MP0003698_abnormal_male_reproductive | 1.11294030 |
| 57 | MP0004133_heterotaxia | 1.10191709 |
| 58 | MP0003119_abnormal_digestive_system | 1.08795840 |
| 59 | MP0008995_early_reproductive_senescence | 1.07185058 |
| 60 | MP0003763_abnormal_thymus_physiology | 1.04490340 |
| 61 | MP0000703_abnormal_thymus_morphology | 1.04271771 |
| 62 | MP0000647_abnormal_sebaceous_gland | 1.04002438 |
| 63 | MP0003861_abnormal_nervous_system | 1.03739449 |
| 64 | MP0008789_abnormal_olfactory_epithelium | 1.02069892 |
| 65 | MP0003315_abnormal_perineum_morphology | 0.99581653 |
| 66 | MP0001119_abnormal_female_reproductive | 0.99578503 |
| 67 | MP0009333_abnormal_splenocyte_physiolog | 0.98807159 |
| 68 | MP0009053_abnormal_anal_canal | 0.97947959 |
| 69 | MP0003806_abnormal_nucleotide_metabolis | 0.97052415 |
| 70 | MP0000049_abnormal_middle_ear | 0.96974699 |
| 71 | MP0000778_abnormal_nervous_system | 0.95899519 |
| 72 | MP0003755_abnormal_palate_morphology | 0.95567550 |
| 73 | MP0006292_abnormal_olfactory_placode | 0.94188453 |
| 74 | MP0001299_abnormal_eye_distance/ | 0.94164987 |
| 75 | MP0003122_maternal_imprinting | 0.92640272 |
| 76 | MP0002398_abnormal_bone_marrow | 0.90557953 |
| 77 | MP0000631_abnormal_neuroendocrine_gland | 0.89728918 |
| 78 | MP0005389_reproductive_system_phenotype | 0.88511300 |
| 79 | MP0009278_abnormal_bone_marrow | 0.87810233 |
| 80 | MP0009672_abnormal_birth_weight | 0.86353900 |
| 81 | MP0003385_abnormal_body_wall | 0.84464601 |
| 82 | MP0005391_vision/eye_phenotype | 0.84283106 |
| 83 | MP0002751_abnormal_autonomic_nervous | 0.83467201 |
| 84 | MP0002254_reproductive_system_inflammat | 0.83446234 |
| 85 | MP0003937_abnormal_limbs/digits/tail_de | 0.82674107 |
| 86 | MP0002722_abnormal_immune_system | 0.81748733 |
| 87 | MP0006276_abnormal_autonomic_nervous | 0.81654388 |
| 88 | MP0000858_altered_metastatic_potential | 0.79575434 |
| 89 | MP0000689_abnormal_spleen_morphology | 0.79480196 |
| 90 | MP0005394_taste/olfaction_phenotype | 0.78302195 |
| 91 | MP0005499_abnormal_olfactory_system | 0.78302195 |
| 92 | MP0002161_abnormal_fertility/fecundity | 0.78229131 |
| 93 | MP0005384_cellular_phenotype | 0.77806986 |
| 94 | MP0002111_abnormal_tail_morphology | 0.77529296 |
| 95 | MP0001915_intracranial_hemorrhage | 0.77511655 |
| 96 | MP0005621_abnormal_cell_physiology | 0.74506209 |
| 97 | MP0000537_abnormal_urethra_morphology | 0.74083134 |
| 98 | MP0003935_abnormal_craniofacial_develop | 0.73814147 |
| 99 | MP0005410_abnormal_fertilization | 0.73635935 |
| 100 | MP0009703_decreased_birth_body | 0.73338543 |
| 101 | MP0002163_abnormal_gland_morphology | 0.73054625 |
| 102 | MP0005187_abnormal_penis_morphology | 0.71881232 |
| 103 | MP0000358_abnormal_cell_content/ | 0.70604254 |
| 104 | MP0002736_abnormal_nociception_after | 0.70391530 |
| 105 | MP0000427_abnormal_hair_cycle | 0.69888123 |
| 106 | MP0005023_abnormal_wound_healing | 0.69364225 |
| 107 | MP0002132_abnormal_respiratory_system | 0.69213996 |
| 108 | MP0003646_muscle_fatigue | 0.68477808 |
| 109 | MP0000579_abnormal_nail_morphology | 0.66330958 |
| 110 | MP0005395_other_phenotype | 0.66303422 |
| 111 | MP0002429_abnormal_blood_cell | 0.65689862 |
| 112 | MP0002092_abnormal_eye_morphology | 0.63773918 |
| 113 | MP0005253_abnormal_eye_physiology | 0.63640526 |
| 114 | MP0003943_abnormal_hepatobiliary_system | 0.63612881 |
| 115 | MP0003787_abnormal_imprinting | 0.63251979 |
| 116 | MP0000432_abnormal_head_morphology | 0.62864993 |
| 117 | MP0002081_perinatal_lethality | 0.62777566 |
| 118 | MP0003880_abnormal_central_pattern | 0.62730642 |
| 119 | MP0000428_abnormal_craniofacial_morphol | 0.62403548 |
| 120 | MP0001286_abnormal_eye_development | 0.61827284 |
| 121 | MP0003186_abnormal_redox_activity | 0.58881998 |
| 122 | MP0003936_abnormal_reproductive_system | 0.56512166 |
| 123 | MP0002075_abnormal_coat/hair_pigmentati | 0.56263556 |
| 124 | MP0003448_altered_tumor_morphology | 0.56240182 |
| 125 | MP0000477_abnormal_intestine_morphology | 0.55357350 |
| 126 | MP0001919_abnormal_reproductive_system | 0.54930280 |
| 127 | MP0002938_white_spotting | 0.54823847 |
| 128 | MP0000716_abnormal_immune_system | 0.54679016 |
| 129 | MP0005367_renal/urinary_system_phenotyp | 0.54464700 |
| 130 | MP0000516_abnormal_urinary_system | 0.54464700 |
| 131 | MP0003699_abnormal_female_reproductive | 0.53913537 |
| 132 | MP0003136_yellow_coat_color | 0.52389942 |
| 133 | MP0001853_heart_inflammation | 0.51494114 |
| 134 | MP0003566_abnormal_cell_adhesion | 0.51113586 |
| 135 | MP0003221_abnormal_cardiomyocyte_apopto | 0.50683162 |
| 136 | MP0005174_abnormal_tail_pigmentation | 0.49734417 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.71368339 |
| 2 | Chromsome breakage (HP:0040012) | 4.18488058 |
| 3 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.94297622 |
| 4 | Medulloblastoma (HP:0002885) | 3.89508098 |
| 5 | Colon cancer (HP:0003003) | 3.78798192 |
| 6 | Breast hypoplasia (HP:0003187) | 3.63158535 |
| 7 | Ependymoma (HP:0002888) | 3.59551124 |
| 8 | Agnosia (HP:0010524) | 3.58478629 |
| 9 | Reticulocytopenia (HP:0001896) | 3.50956751 |
| 10 | Abnormality of chromosome stability (HP:0003220) | 3.31967431 |
| 11 | Degeneration of anterior horn cells (HP:0002398) | 3.28688186 |
| 12 | Abnormality of the anterior horn cell (HP:0006802) | 3.28688186 |
| 13 | Selective tooth agenesis (HP:0001592) | 3.25708813 |
| 14 | Patellar aplasia (HP:0006443) | 3.21006214 |
| 15 | Meckel diverticulum (HP:0002245) | 3.20224411 |
| 16 | Abnormality of the ileum (HP:0001549) | 3.05332575 |
| 17 | Abnormality of the preputium (HP:0100587) | 3.04791871 |
| 18 | 11 pairs of ribs (HP:0000878) | 3.01999806 |
| 19 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.99549531 |
| 20 | Supernumerary spleens (HP:0009799) | 2.97308042 |
| 21 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.96360403 |
| 22 | Carpal bone hypoplasia (HP:0001498) | 2.95672475 |
| 23 | Absent thumb (HP:0009777) | 2.94267552 |
| 24 | Rhabdomyosarcoma (HP:0002859) | 2.92524659 |
| 25 | Abnormality of the labia minora (HP:0012880) | 2.83552912 |
| 26 | Impulsivity (HP:0100710) | 2.82662128 |
| 27 | Absent radius (HP:0003974) | 2.80991450 |
| 28 | Oral leukoplakia (HP:0002745) | 2.79945104 |
| 29 | Ectopic kidney (HP:0000086) | 2.78544247 |
| 30 | Aplastic anemia (HP:0001915) | 2.77919462 |
| 31 | Myelodysplasia (HP:0002863) | 2.70981496 |
| 32 | Small intestinal stenosis (HP:0012848) | 2.69529781 |
| 33 | Duodenal stenosis (HP:0100867) | 2.69529781 |
| 34 | Neoplasm of the adrenal cortex (HP:0100641) | 2.63780602 |
| 35 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.63027037 |
| 36 | Absent forearm bone (HP:0003953) | 2.60312389 |
| 37 | Aplasia involving forearm bones (HP:0009822) | 2.60312389 |
| 38 | Septo-optic dysplasia (HP:0100842) | 2.54183576 |
| 39 | Neoplasm of the oral cavity (HP:0100649) | 2.53929502 |
| 40 | Basal cell carcinoma (HP:0002671) | 2.51121121 |
| 41 | Abnormal spermatogenesis (HP:0008669) | 2.49920370 |
| 42 | Sloping forehead (HP:0000340) | 2.45429181 |
| 43 | Abnormal lung lobation (HP:0002101) | 2.44641449 |
| 44 | Neoplasm of the pancreas (HP:0002894) | 2.44607169 |
| 45 | Abnormal number of erythroid precursors (HP:0012131) | 2.43458728 |
| 46 | Abnormality of the astrocytes (HP:0100707) | 2.38214180 |
| 47 | Astrocytoma (HP:0009592) | 2.38214180 |
| 48 | Rough bone trabeculation (HP:0100670) | 2.37725946 |
| 49 | Missing ribs (HP:0000921) | 2.31484846 |
| 50 | Glioma (HP:0009733) | 2.30877111 |
| 51 | Bone marrow hypocellularity (HP:0005528) | 2.28874890 |
| 52 | Neoplasm of striated muscle (HP:0009728) | 2.24360371 |
| 53 | Hepatoblastoma (HP:0002884) | 2.24286808 |
| 54 | Biliary tract neoplasm (HP:0100574) | 2.24028558 |
| 55 | Stenosis of the external auditory canal (HP:0000402) | 2.23953785 |
| 56 | Facial hemangioma (HP:0000329) | 2.22958466 |
| 57 | Abnormality of the duodenum (HP:0002246) | 2.22729818 |
| 58 | Tracheoesophageal fistula (HP:0002575) | 2.21843625 |
| 59 | Proximal placement of thumb (HP:0009623) | 2.19678981 |
| 60 | Abnormal hair whorl (HP:0010721) | 2.19517127 |
| 61 | Premature graying of hair (HP:0002216) | 2.19424420 |
| 62 | Volvulus (HP:0002580) | 2.18166416 |
| 63 | Horseshoe kidney (HP:0000085) | 2.17487579 |
| 64 | Atresia of the external auditory canal (HP:0000413) | 2.17181846 |
| 65 | Increased nuchal translucency (HP:0010880) | 2.13865290 |
| 66 | Deviation of the thumb (HP:0009603) | 2.12974676 |
| 67 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.10465140 |
| 68 | Abnormality of the carotid arteries (HP:0005344) | 2.10423903 |
| 69 | Hyperglycinemia (HP:0002154) | 2.10396647 |
| 70 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.09704257 |
| 71 | Short thumb (HP:0009778) | 2.08931265 |
| 72 | Cortical dysplasia (HP:0002539) | 2.08630466 |
| 73 | Duplicated collecting system (HP:0000081) | 2.07597126 |
| 74 | Intestinal atresia (HP:0011100) | 2.07180655 |
| 75 | Triphalangeal thumb (HP:0001199) | 2.06702286 |
| 76 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.06480698 |
| 77 | Abnormal number of incisors (HP:0011064) | 2.05766621 |
| 78 | Trismus (HP:0000211) | 2.03197540 |
| 79 | Cafe-au-lait spot (HP:0000957) | 2.01153411 |
| 80 | Facial cleft (HP:0002006) | 2.01049883 |
| 81 | Neoplasm of the colon (HP:0100273) | 2.00659306 |
| 82 | Hyperalaninemia (HP:0003348) | 1.99664212 |
| 83 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.99664212 |
| 84 | Abnormality of alanine metabolism (HP:0010916) | 1.99664212 |
| 85 | Amaurosis fugax (HP:0100576) | 1.96987309 |
| 86 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.96785843 |
| 87 | Pallor (HP:0000980) | 1.96682409 |
| 88 | Abnormality of the renal collecting system (HP:0004742) | 1.96676597 |
| 89 | Cleft eyelid (HP:0000625) | 1.96236134 |
| 90 | Embryonal renal neoplasm (HP:0011794) | 1.95080566 |
| 91 | Cellular immunodeficiency (HP:0005374) | 1.94570881 |
| 92 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.93479959 |
| 93 | Abnormality of abdominal situs (HP:0011620) | 1.91593089 |
| 94 | Abdominal situs inversus (HP:0003363) | 1.91593089 |
| 95 | Premature ovarian failure (HP:0008209) | 1.91066977 |
| 96 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.90152441 |
| 97 | Short 4th metacarpal (HP:0010044) | 1.90152441 |
| 98 | Prominent nose (HP:0000448) | 1.89845410 |
| 99 | Hypoplasia of the radius (HP:0002984) | 1.88656506 |
| 100 | Abnormality of the metopic suture (HP:0005556) | 1.88591515 |
| 101 | Cerebral hypomyelination (HP:0006808) | 1.86892316 |
| 102 | Pancreatic cysts (HP:0001737) | 1.86453020 |
| 103 | Macrocytic anemia (HP:0001972) | 1.85606319 |
| 104 | Prominent metopic ridge (HP:0005487) | 1.84404260 |
| 105 | Clubbing of toes (HP:0100760) | 1.84342298 |
| 106 | Abnormality of the septum pellucidum (HP:0007375) | 1.83439035 |
| 107 | Dandy-Walker malformation (HP:0001305) | 1.82850328 |
| 108 | Multiple enchondromatosis (HP:0005701) | 1.82464061 |
| 109 | Squamous cell carcinoma (HP:0002860) | 1.82240006 |
| 110 | Preaxial hand polydactyly (HP:0001177) | 1.81514511 |
| 111 | Azoospermia (HP:0000027) | 1.81279992 |
| 112 | Bifid tongue (HP:0010297) | 1.81182447 |
| 113 | Abnormality of serum amino acid levels (HP:0003112) | 1.80262883 |
| 114 | Lymphoma (HP:0002665) | 1.80174206 |
| 115 | Nephronophthisis (HP:0000090) | 1.77761407 |
| 116 | Rectal fistula (HP:0100590) | 1.77432081 |
| 117 | Rectovaginal fistula (HP:0000143) | 1.77432081 |
| 118 | Esophageal atresia (HP:0002032) | 1.75791488 |
| 119 | Small hand (HP:0200055) | 1.75549396 |
| 120 | Microretrognathia (HP:0000308) | 1.75284651 |
| 121 | Spinal muscular atrophy (HP:0007269) | 1.75035571 |
| 122 | Gastrointestinal atresia (HP:0002589) | 1.74254430 |
| 123 | Abnormality of DNA repair (HP:0003254) | 1.74022335 |
| 124 | Ovarian neoplasm (HP:0100615) | 1.73508546 |
| 125 | Molar tooth sign on MRI (HP:0002419) | 1.73481850 |
| 126 | Abnormality of midbrain morphology (HP:0002418) | 1.73481850 |
| 127 | Absent septum pellucidum (HP:0001331) | 1.72639131 |
| 128 | Pancreatic fibrosis (HP:0100732) | 1.72352687 |
| 129 | Hypoplastic female external genitalia (HP:0012815) | 1.71592912 |
| 130 | Tubulointerstitial nephritis (HP:0001970) | 1.65752562 |
| 131 | Microvesicular hepatic steatosis (HP:0001414) | 1.62059862 |
| 132 | High anterior hairline (HP:0009890) | 1.61447258 |
| 133 | Choanal atresia (HP:0000453) | 1.60061770 |
| 134 | Breast aplasia (HP:0100783) | 1.59828024 |
| 135 | Hypoplastic pelvis (HP:0008839) | 1.59789773 |
| 136 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.59407530 |
| 137 | Oligodactyly (hands) (HP:0001180) | 1.59028250 |
| 138 | Embryonal neoplasm (HP:0002898) | 1.56918686 |
| 139 | Arteriovenous malformation (HP:0100026) | 1.56917832 |
| 140 | Renal hypoplasia (HP:0000089) | 1.56819534 |
| 141 | Hypoplasia of the pons (HP:0012110) | 1.56798637 |
| 142 | Median cleft lip (HP:0000161) | 1.56434870 |
| 143 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.55739921 |
| 144 | Bilateral microphthalmos (HP:0007633) | 1.55374189 |
| 145 | Optic nerve hypoplasia (HP:0000609) | 1.54526628 |
| 146 | Labial hypoplasia (HP:0000066) | 1.54237124 |
| 147 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.53614377 |
| 148 | Abnormality of the pons (HP:0007361) | 1.53553084 |
| 149 | Increased hepatocellular lipid droplets (HP:0006565) | 1.52844404 |
| 150 | Astigmatism (HP:0000483) | 1.52485030 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.99872476 |
| 2 | WEE1 | 4.40011897 |
| 3 | BUB1 | 4.14633785 |
| 4 | ACVR1B | 3.47659785 |
| 5 | EIF2AK1 | 2.87996194 |
| 6 | CDK12 | 2.81013881 |
| 7 | NEK2 | 2.66249948 |
| 8 | TTK | 2.51306179 |
| 9 | SRPK1 | 2.50019184 |
| 10 | NUAK1 | 2.40095874 |
| 11 | TSSK6 | 2.31865451 |
| 12 | PLK4 | 2.27515955 |
| 13 | PLK1 | 2.14418159 |
| 14 | NEK1 | 2.02873838 |
| 15 | FRK | 2.00841172 |
| 16 | BRSK2 | 1.96296137 |
| 17 | ATR | 1.95305071 |
| 18 | VRK2 | 1.90662402 |
| 19 | WNK3 | 1.88284451 |
| 20 | PASK | 1.86470094 |
| 21 | CDK7 | 1.84437397 |
| 22 | TRIM28 | 1.79732178 |
| 23 | BMPR1B | 1.78344214 |
| 24 | TNIK | 1.77647881 |
| 25 | MKNK1 | 1.73589434 |
| 26 | TAF1 | 1.72330457 |
| 27 | AURKB | 1.65947193 |
| 28 | PLK3 | 1.65664729 |
| 29 | CHEK2 | 1.57436041 |
| 30 | EPHA2 | 1.55872672 |
| 31 | RPS6KB2 | 1.55820251 |
| 32 | EIF2AK3 | 1.54594092 |
| 33 | VRK1 | 1.47199831 |
| 34 | TESK2 | 1.45725012 |
| 35 | CHEK1 | 1.45428306 |
| 36 | RPS6KA4 | 1.42158717 |
| 37 | TGFBR1 | 1.41140901 |
| 38 | BRD4 | 1.39524007 |
| 39 | DYRK3 | 1.39335795 |
| 40 | TLK1 | 1.38413039 |
| 41 | STK16 | 1.33494092 |
| 42 | MKNK2 | 1.29562796 |
| 43 | CDK4 | 1.26284601 |
| 44 | STK10 | 1.26275820 |
| 45 | AURKA | 1.24881372 |
| 46 | NME2 | 1.23622410 |
| 47 | BCR | 1.18857518 |
| 48 | MAP3K8 | 1.17664315 |
| 49 | SCYL2 | 1.16374443 |
| 50 | ATM | 1.14949998 |
| 51 | PDK3 | 1.14588734 |
| 52 | PDK4 | 1.14588734 |
| 53 | LATS1 | 1.10107596 |
| 54 | STK4 | 1.09793724 |
| 55 | PBK | 1.00303970 |
| 56 | BRSK1 | 0.98084906 |
| 57 | ZAK | 0.97451904 |
| 58 | CDK2 | 0.96731943 |
| 59 | MELK | 0.95387951 |
| 60 | CDK19 | 0.95008492 |
| 61 | TESK1 | 0.93508814 |
| 62 | PIM1 | 0.92338033 |
| 63 | CASK | 0.89614082 |
| 64 | PNCK | 0.89512189 |
| 65 | MAP3K4 | 0.88573133 |
| 66 | ERBB4 | 0.88563970 |
| 67 | BRAF | 0.87755726 |
| 68 | DYRK2 | 0.83875014 |
| 69 | PLK2 | 0.82600130 |
| 70 | PAK4 | 0.80693637 |
| 71 | FLT3 | 0.79308957 |
| 72 | EEF2K | 0.78601532 |
| 73 | CCNB1 | 0.76065941 |
| 74 | MAP3K10 | 0.75673891 |
| 75 | PDK2 | 0.75657328 |
| 76 | INSRR | 0.73768007 |
| 77 | CDK1 | 0.73718323 |
| 78 | CSNK2A2 | 0.73469433 |
| 79 | NME1 | 0.72502898 |
| 80 | CDK6 | 0.69063990 |
| 81 | CAMK1G | 0.67080592 |
| 82 | STK3 | 0.66781450 |
| 83 | MAP4K2 | 0.65048750 |
| 84 | AKT3 | 0.64695277 |
| 85 | CSNK2A1 | 0.62979654 |
| 86 | CAMK1D | 0.61261279 |
| 87 | ALK | 0.60918085 |
| 88 | CSNK1G1 | 0.60415160 |
| 89 | PIM2 | 0.59446605 |
| 90 | RPS6KA5 | 0.59118280 |
| 91 | PAK1 | 0.58989951 |
| 92 | STK38L | 0.55677644 |
| 93 | CDK3 | 0.55167066 |
| 94 | CSNK1G2 | 0.54449317 |
| 95 | ERBB3 | 0.53682584 |
| 96 | CDK8 | 0.52662120 |
| 97 | MAP2K7 | 0.51629959 |
| 98 | GRK1 | 0.51009503 |
| 99 | CLK1 | 0.50527816 |
| 100 | EIF2AK2 | 0.48760521 |
| 101 | MTOR | 0.46872800 |
| 102 | MAP4K1 | 0.46098455 |
| 103 | CSNK1G3 | 0.45491591 |
| 104 | CSNK1A1L | 0.44800501 |
| 105 | MST4 | 0.44735460 |
| 106 | OXSR1 | 0.43483398 |
| 107 | PRKDC | 0.42342645 |
| 108 | FGFR2 | 0.41599786 |
| 109 | PRKCI | 0.40858410 |
| 110 | KDR | 0.39678712 |
| 111 | CSNK1E | 0.39285140 |
| 112 | MAP2K3 | 0.37406384 |
| 113 | CSNK1D | 0.36639322 |
| 114 | PRKCG | 0.34998211 |
| 115 | CHUK | 0.34667596 |
| 116 | MAP3K3 | 0.34199524 |
| 117 | WNK4 | 0.32132543 |
| 118 | RAF1 | 0.30816688 |
| 119 | RPS6KB1 | 0.30415893 |
| 120 | JAK3 | 0.30366233 |
| 121 | MARK3 | 0.30193599 |
| 122 | PKN2 | 0.30187152 |
| 123 | MAPK14 | 0.29223275 |
| 124 | TEC | 0.28488331 |
| 125 | BCKDK | 0.27195385 |
| 126 | MAPKAPK3 | 0.26990755 |
| 127 | DMPK | 0.26813597 |
| 128 | STK24 | 0.26748104 |
| 129 | LRRK2 | 0.26485650 |
| 130 | KSR1 | 0.25513223 |
| 131 | FGFR1 | 0.24941151 |
| 132 | TXK | 0.24144763 |
| 133 | AKT1 | 0.22910217 |
| 134 | YES1 | 0.22610059 |
| 135 | ZAP70 | 0.22546444 |
| 136 | GSK3B | 0.22111929 |
| 137 | MAPK1 | 0.21695368 |
| 138 | BTK | 0.21530208 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.73253903 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.43101871 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.12327263 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 3.35030981 |
| 5 | RNA transport_Homo sapiens_hsa03013 | 3.26135946 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 3.25987600 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 3.10553919 |
| 8 | Proteasome_Homo sapiens_hsa03050 | 2.99949330 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.93119833 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.83832576 |
| 11 | Cell cycle_Homo sapiens_hsa04110 | 2.81023808 |
| 12 | Ribosome_Homo sapiens_hsa03010 | 2.75994086 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.60612204 |
| 14 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.56212342 |
| 15 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.55746645 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 2.38674333 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.36052486 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.24866564 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 2.08678257 |
| 20 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.00238318 |
| 21 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.65399387 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.61879595 |
| 23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.41753110 |
| 24 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.33080468 |
| 25 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.28510154 |
| 26 | Purine metabolism_Homo sapiens_hsa00230 | 1.25635499 |
| 27 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.24383217 |
| 28 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.22583945 |
| 29 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.10681218 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.10085665 |
| 31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.09969620 |
| 32 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.06432275 |
| 33 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.05982203 |
| 34 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.04104579 |
| 35 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.00335648 |
| 36 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.00253119 |
| 37 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.96997875 |
| 38 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.95483825 |
| 39 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.94783886 |
| 40 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.90936922 |
| 41 | Parkinsons disease_Homo sapiens_hsa05012 | 0.88988120 |
| 42 | HTLV-I infection_Homo sapiens_hsa05166 | 0.86598148 |
| 43 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.80781668 |
| 44 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.80523831 |
| 45 | Thyroid cancer_Homo sapiens_hsa05216 | 0.76282431 |
| 46 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.74262544 |
| 47 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.69372777 |
| 48 | Legionellosis_Homo sapiens_hsa05134 | 0.65993527 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.65908876 |
| 50 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.64522303 |
| 51 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.64302916 |
| 52 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.61573192 |
| 53 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.61200513 |
| 54 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.59636283 |
| 55 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.59604674 |
| 56 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.59400806 |
| 57 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.57912033 |
| 58 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.55966329 |
| 59 | Phototransduction_Homo sapiens_hsa04744 | 0.55921998 |
| 60 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.53052108 |
| 61 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.52855944 |
| 62 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.52174366 |
| 63 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.51310207 |
| 64 | Colorectal cancer_Homo sapiens_hsa05210 | 0.49902234 |
| 65 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.48964367 |
| 66 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45945128 |
| 67 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.45508154 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.45306597 |
| 69 | Measles_Homo sapiens_hsa05162 | 0.44902957 |
| 70 | Protein export_Homo sapiens_hsa03060 | 0.44517393 |
| 71 | Alcoholism_Homo sapiens_hsa05034 | 0.44379712 |
| 72 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.43552968 |
| 73 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.41321998 |
| 74 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.40995061 |
| 75 | Shigellosis_Homo sapiens_hsa05131 | 0.40060934 |
| 76 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.39768198 |
| 77 | Apoptosis_Homo sapiens_hsa04210 | 0.39027510 |
| 78 | Influenza A_Homo sapiens_hsa05164 | 0.38181277 |
| 79 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.36961922 |
| 80 | Nicotine addiction_Homo sapiens_hsa05033 | 0.36507671 |
| 81 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.36462300 |
| 82 | Hepatitis B_Homo sapiens_hsa05161 | 0.34471322 |
| 83 | Huntingtons disease_Homo sapiens_hsa05016 | 0.32962347 |
| 84 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.32880150 |
| 85 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.32582261 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.32088499 |
| 87 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.31851672 |
| 88 | Pathways in cancer_Homo sapiens_hsa05200 | 0.31227613 |
| 89 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.31154859 |
| 90 | Alzheimers disease_Homo sapiens_hsa05010 | 0.30672738 |
| 91 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.30614662 |
| 92 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.29099259 |
| 93 | Adherens junction_Homo sapiens_hsa04520 | 0.28962160 |
| 94 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.28740529 |
| 95 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.28728040 |
| 96 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.28161634 |
| 97 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.27947883 |
| 98 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.27350155 |
| 99 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.27068579 |
| 100 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.26852787 |
| 101 | Allograft rejection_Homo sapiens_hsa05330 | 0.26224899 |
| 102 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.26009241 |
| 103 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.24317551 |
| 104 | Sulfur relay system_Homo sapiens_hsa04122 | 0.24307062 |
| 105 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.24000790 |
| 106 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.23714549 |
| 107 | Bladder cancer_Homo sapiens_hsa05219 | 0.23418849 |
| 108 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.23317686 |
| 109 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.23093266 |
| 110 | Prostate cancer_Homo sapiens_hsa05215 | 0.22923328 |
| 111 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.22812232 |
| 112 | Peroxisome_Homo sapiens_hsa04146 | 0.22511030 |
| 113 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.21857841 |
| 114 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.21257421 |
| 115 | Viral myocarditis_Homo sapiens_hsa05416 | 0.20695534 |
| 116 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.20418429 |
| 117 | Tight junction_Homo sapiens_hsa04530 | 0.20383209 |
| 118 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.19842097 |
| 119 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.18315970 |
| 120 | Taste transduction_Homo sapiens_hsa04742 | 0.18077609 |
| 121 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.17643010 |
| 122 | Olfactory transduction_Homo sapiens_hsa04740 | 0.17564102 |
| 123 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.17042896 |
| 124 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.15814787 |
| 125 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.15747274 |
| 126 | Asthma_Homo sapiens_hsa05310 | 0.15595008 |
| 127 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.15359366 |
| 128 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.14374345 |
| 129 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.13954871 |
| 130 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.13786800 |
| 131 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.13134621 |
| 132 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.12686553 |
| 133 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.12665895 |
| 134 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.11185915 |
| 135 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.11094669 |
| 136 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.10277854 |
| 137 | Melanoma_Homo sapiens_hsa05218 | 0.09615660 |
| 138 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.09221274 |
| 139 | Lysine degradation_Homo sapiens_hsa00310 | 0.09158155 |
| 140 | Carbon metabolism_Homo sapiens_hsa01200 | 0.08351816 |

