TEX101

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.76599427
2regulation of meiosis I (GO:0060631)9.56835498
3male meiosis I (GO:0007141)9.54737808
4chromosome organization involved in meiosis (GO:0070192)8.91537812
5meiotic nuclear division (GO:0007126)8.68235356
6meiosis I (GO:0007127)7.91757391
7plasma membrane fusion (GO:0045026)7.32525221
8acrosome assembly (GO:0001675)7.24326523
9sperm motility (GO:0030317)7.17368205
10spermatid development (GO:0007286)7.12940238
11axonemal dynein complex assembly (GO:0070286)7.12324143
12sperm-egg recognition (GO:0035036)6.96087085
13binding of sperm to zona pellucida (GO:0007339)6.74161683
14gene silencing by RNA (GO:0031047)6.69943833
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)6.28166003
16negative regulation of translation, ncRNA-mediated (GO:0040033)6.28166003
17regulation of translation, ncRNA-mediated (GO:0045974)6.28166003
18multicellular organism reproduction (GO:0032504)6.25968377
19cell-cell recognition (GO:0009988)6.20433286
20endothelial cell chemotaxis (GO:0035767)6.02678232
21epithelial cilium movement (GO:0003351)5.96145369
22meiotic cell cycle (GO:0051321)5.88120057
23meiotic cell cycle process (GO:1903046)5.78099108
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.66438158
25motile cilium assembly (GO:0044458)5.56651950
26acrosome reaction (GO:0007340)5.53793821
27germ cell development (GO:0007281)5.31587520
28cilium movement (GO:0003341)5.26268554
29DNA alkylation (GO:0006305)5.10840743
30DNA methylation (GO:0006306)5.10840743
31spermatogenesis (GO:0007283)4.99584985
32male gamete generation (GO:0048232)4.98433256
33reproduction (GO:0000003)4.94771937
34cellular process involved in reproduction in multicellular organism (GO:0022412)4.90855565
35regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.90494194
36positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.90494194
37synapsis (GO:0007129)4.89624852
38fertilization (GO:0009566)4.79502419
39sex differentiation (GO:0007548)4.66718426
40neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.61941768
41gamete generation (GO:0007276)4.61102723
42genitalia morphogenesis (GO:0035112)4.57570795
43gene silencing (GO:0016458)4.46704153
44oogenesis (GO:0048477)4.46556864
45negative regulation of inclusion body assembly (GO:0090084)4.45052112
46nuclear pore complex assembly (GO:0051292)4.44515755
47regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.42306207
48positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.42306207
49single fertilization (GO:0007338)4.33426025
50regulation of cilium movement (GO:0003352)4.32489760
51positive regulation of meiosis (GO:0045836)4.31674082
52cell wall macromolecule metabolic process (GO:0044036)4.27255844
53cell wall macromolecule catabolic process (GO:0016998)4.27255844
54seminiferous tubule development (GO:0072520)4.23559837
55pre-miRNA processing (GO:0031054)4.13712721
56positive regulation of meiotic cell cycle (GO:0051446)4.11161520
57sister chromatid cohesion (GO:0007062)4.10760918
58regulation of female gonad development (GO:2000194)4.06004214
59negative regulation of meiosis (GO:0045835)3.99467212
60reciprocal DNA recombination (GO:0035825)3.94693608
61reciprocal meiotic recombination (GO:0007131)3.94693608
62nuclear pore organization (GO:0006999)3.92834434
63monoubiquitinated protein deubiquitination (GO:0035520)3.92005917
64DNA methylation or demethylation (GO:0044728)3.86159371
65glucocorticoid receptor signaling pathway (GO:0042921)3.80911525
66multicellular organismal movement (GO:0050879)3.79574320
67musculoskeletal movement (GO:0050881)3.79574320
68ganglion development (GO:0061548)3.79404605
69interkinetic nuclear migration (GO:0022027)3.77184258
70cerebellar granule cell differentiation (GO:0021707)3.76629504
71positive regulation of CREB transcription factor activity (GO:0032793)3.74479203
72meiotic chromosome segregation (GO:0045132)3.70619173
73sperm capacitation (GO:0048240)3.68653571
74resolution of meiotic recombination intermediates (GO:0000712)3.68044625
75regulation of sarcomere organization (GO:0060297)3.66675165
76cell differentiation in hindbrain (GO:0021533)3.65297252
77regulation of inclusion body assembly (GO:0090083)3.60880473
78multicellular organismal reproductive process (GO:0048609)3.58200002
79protein localization to cilium (GO:0061512)3.57712390
80regulation of histone H3-K9 methylation (GO:0051570)3.54509524
81microtubule depolymerization (GO:0007019)3.48978272
82regulation of protein polyubiquitination (GO:1902914)3.48773020
83oocyte development (GO:0048599)3.48221244
84cerebellar Purkinje cell differentiation (GO:0021702)3.44662164
85ventricular system development (GO:0021591)3.44429585
86regulation of centriole replication (GO:0046599)3.43471733
87histone H3-K9 demethylation (GO:0033169)3.43329925
88lymphangiogenesis (GO:0001946)3.41202661
89female gamete generation (GO:0007292)3.40861891
90positive regulation of mRNA catabolic process (GO:0061014)3.40693865
91positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.40154471
92mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.40154471
93pore complex assembly (GO:0046931)3.38126035
94leukotriene biosynthetic process (GO:0019370)3.37300779
95DNA synthesis involved in DNA repair (GO:0000731)3.35786933
96translesion synthesis (GO:0019985)3.35778802
97corticosteroid receptor signaling pathway (GO:0031958)3.30196932
98definitive hemopoiesis (GO:0060216)3.28462537
99histone H3-K4 trimethylation (GO:0080182)3.27530354
100embryonic retina morphogenesis in camera-type eye (GO:0060059)3.24837682
101heterochromatin organization (GO:0070828)3.24272303
102negative regulation of DNA repair (GO:0045738)3.23810010
103negative regulation of organelle assembly (GO:1902116)3.23442551
104histone H3-K4 methylation (GO:0051568)3.21559502
105neural tube development (GO:0021915)3.19937976
106striated muscle atrophy (GO:0014891)3.19111302
107intraciliary transport (GO:0042073)3.15700568
108N-terminal protein amino acid acetylation (GO:0006474)3.15038139
109regulation of meiosis (GO:0040020)3.15013949
110positive regulation of male gonad development (GO:2000020)3.13770251
111positive regulation of translational initiation (GO:0045948)3.12384305
112chaperone-mediated protein complex assembly (GO:0051131)3.11536485
113DNA modification (GO:0006304)3.09890085
114regulation of mRNA catabolic process (GO:0061013)3.06747265
115skeletal muscle adaptation (GO:0043501)3.06084841
116DNA replication-dependent nucleosome assembly (GO:0006335)3.06043810
117DNA replication-dependent nucleosome organization (GO:0034723)3.06043810
118histone exchange (GO:0043486)3.04614443
119regulation of microtubule-based movement (GO:0060632)3.04243334
120DNA packaging (GO:0006323)3.03115549
121blastocyst development (GO:0001824)3.02616137
122neurotransmitter-gated ion channel clustering (GO:0072578)3.00383960
123cell migration in hindbrain (GO:0021535)2.93237274
124chromatin silencing (GO:0006342)2.91806604
125regulation of chromatin binding (GO:0035561)2.91118587
126collecting duct development (GO:0072044)2.89932110
127DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.89700397
128regulation of synapse maturation (GO:0090128)2.88167948
129positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.87970804
130histone lysine methylation (GO:0034968)2.87209161
131poly(A)+ mRNA export from nucleus (GO:0016973)2.87149855
132negative regulation of cAMP-mediated signaling (GO:0043951)2.86518655
133histone H3-K36 demethylation (GO:0070544)2.85743687
134membrane depolarization during action potential (GO:0086010)2.85193768
135mitotic sister chromatid cohesion (GO:0007064)2.82439675
136metanephric nephron epithelium development (GO:0072243)2.81404835
137microtubule severing (GO:0051013)2.81110148
138cell recognition (GO:0008037)2.78746480
139chromosome organization (GO:0051276)2.76576088
140nuclear division (GO:0000280)2.76439661
141histone H3-K9 methylation (GO:0051567)2.75351184
142left/right pattern formation (GO:0060972)2.74970296
143response to misfolded protein (GO:0051788)2.73576460
144negative regulation of myotube differentiation (GO:0010832)2.72433175
145G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72351796
146positive regulation of synapse maturation (GO:0090129)2.71775740
147histone H2A acetylation (GO:0043968)2.71743196
148transmission of nerve impulse (GO:0019226)2.71292370
149positive regulation of mitochondrial membrane permeability (GO:0035794)2.70743419
150detection of molecule of bacterial origin (GO:0032490)2.69733062
151enteric nervous system development (GO:0048484)2.69675928
152protein K48-linked deubiquitination (GO:0071108)2.69167553
153positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68063584
154ovulation cycle (GO:0042698)2.67987934
155negative regulation of actin filament bundle assembly (GO:0032232)2.65884910
156regulation of somitogenesis (GO:0014807)2.65404089
157positive regulation of mRNA 3-end processing (GO:0031442)2.64945444
158metanephric epithelium development (GO:0072207)2.63958383
159venous blood vessel morphogenesis (GO:0048845)2.63928412
160lipid translocation (GO:0034204)2.58847398
161phospholipid translocation (GO:0045332)2.58847398
162DNA damage response, signal transduction resulting in transcription (GO:0042772)2.58469938
163positive regulation of gene expression, epigenetic (GO:0045815)2.57275980
164response to inactivity (GO:0014854)2.56573196
165gamma-aminobutyric acid transport (GO:0015812)2.56378796
166heart morphogenesis (GO:0003007)2.53505531
167regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.52940929
168negative regulation of fibroblast proliferation (GO:0048147)2.52578488
169metanephric tubule development (GO:0072170)2.49349111
170metanephric nephron tubule development (GO:0072234)2.49349111
171positive regulation of mRNA processing (GO:0050685)2.47964971
172regulation of p38MAPK cascade (GO:1900744)2.47582518
173regulation of ARF GTPase activity (GO:0032312)2.46982850
174peristalsis (GO:0030432)2.46871163
175histone lysine demethylation (GO:0070076)2.45110776
176muscle atrophy (GO:0014889)2.44217952
177snRNA transcription (GO:0009301)2.43732105
178male sex determination (GO:0030238)2.43352971
179nucleus localization (GO:0051647)2.43027307
180negative regulation of gluconeogenesis (GO:0045721)2.42919854
181negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.41732109
182nephron epithelium development (GO:0072009)2.40056001
183nephron tubule morphogenesis (GO:0072078)2.39240170
184nephron epithelium morphogenesis (GO:0072088)2.39240170
185regulation of establishment of cell polarity (GO:2000114)2.38483960
186semaphorin-plexin signaling pathway (GO:0071526)2.37966819
187histone demethylation (GO:0016577)2.37269796
188piRNA metabolic process (GO:0034587)17.1862348
189male meiosis (GO:0007140)12.7677252
190synaptonemal complex assembly (GO:0007130)12.7185430
191synaptonemal complex organization (GO:0070193)12.6673701
192DNA methylation involved in gamete generation (GO:0043046)11.8992276
193cilium or flagellum-dependent cell motility (GO:0001539)10.4834457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.76703148
2DROSHA_22980978_ChIP-Seq_HELA_Human3.29105357
3EZH2_22144423_ChIP-Seq_EOC_Human3.21547964
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13982648
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13119615
6* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse3.02014744
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90220467
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.55217540
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.47677891
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.24228010
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01478589
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse13.7936300
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93173681
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82397524
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79420115
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78408310
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.76247924
18VDR_22108803_ChIP-Seq_LS180_Human1.72821973
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67940476
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64358713
21RNF2_27304074_Chip-Seq_NSC_Mouse1.63697036
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63549083
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63288055
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62739346
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62694504
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60442156
27AR_21572438_ChIP-Seq_LNCaP_Human1.59190006
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57870575
29AR_21909140_ChIP-Seq_LNCAP_Human1.56355353
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54915180
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54754734
32NFIB_24661679_ChIP-Seq_LUNG_Mouse1.53821977
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51756583
34ZNF274_21170338_ChIP-Seq_K562_Hela1.51577428
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.51571951
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.51505113
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51501525
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50799317
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.49651734
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49247640
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49138002
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49138002
43E2F7_22180533_ChIP-Seq_HELA_Human1.48740968
44GBX2_23144817_ChIP-Seq_PC3_Human1.47120637
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46440544
46FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45680911
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45547535
48SCL_19346495_ChIP-Seq_HPC-7_Human1.45275973
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.44822804
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.44139598
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.43604063
52RUNX1_26923725_Chip-Seq_HPCs_Mouse1.43455947
53RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43180788
54* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41471104
55AHR_22903824_ChIP-Seq_MCF-7_Human1.39375462
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.35648562
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35012874
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34812043
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32661677
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31466450
61SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.29490625
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29262934
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28897656
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25746402
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23902072
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23635603
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22642023
68* REST_21632747_ChIP-Seq_MESCs_Mouse1.21941316
69STAT3_23295773_ChIP-Seq_U87_Human1.21897214
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.21528155
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20655483
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19072411
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18014804
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17628007
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17497510
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17187531
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16860255
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13378445
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12912292
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12363551
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12185803
82STAT1_17558387_ChIP-Seq_HELA_Human1.11857104
83SMAD4_21799915_ChIP-Seq_A2780_Human1.10711899
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09305884
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09004156
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08704545
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06965911
88SMAD4_21741376_ChIP-Seq_HESCs_Human1.06946316
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06482068
90RXR_22108803_ChIP-Seq_LS180_Human1.06269809
91SPI1_23127762_ChIP-Seq_K562_Human1.03062962
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03023158
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.01047718
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00356686
95KDM2B_26808549_Chip-Seq_K562_Human1.00268981
96TP53_16413492_ChIP-PET_HCT116_Human1.00173368
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99708354
98GATA3_21867929_ChIP-Seq_TH1_Mouse0.98900547
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98638505
100GATA3_21867929_ChIP-Seq_CD8_Mouse0.98398662
101* AR_19668381_ChIP-Seq_PC3_Human0.98225930
102FOXA2_19822575_ChIP-Seq_HepG2_Human0.98128055
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97855773
104GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.97845306
105BCAT_22108803_ChIP-Seq_LS180_Human0.97188568
106YY1_22570637_ChIP-Seq_MALME-3M_Human0.97004223
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.96118772
108SALL1_21062744_ChIP-ChIP_HESCs_Human0.95693505
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95644377
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.95420398
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95412932
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94774951
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93869847
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93842226
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93644692
116BP1_19119308_ChIP-ChIP_Hs578T_Human0.92730760
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92492277
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92155550
119FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92117403
120GATA3_26560356_Chip-Seq_TH1_Human0.91748916
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.91398630
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91121275
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.91023492
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90262853
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90262853
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.90138800
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89189012
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88670548
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88289158
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87768722
131KDM5A_27292631_Chip-Seq_BREAST_Human0.87340933
132KLF5_25053715_ChIP-Seq_YYC3_Human0.87079142
133* OCT4_19829295_ChIP-Seq_ESCs_Human0.86921063
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86843223
135CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86391180
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.86178910
137* SOX2_21211035_ChIP-Seq_LN229_Human0.86022012
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85097291
139RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85015872
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84643261
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84570997
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.84399556
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.83890363
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.83675177
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82754108
146* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.82121304
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81878984
148E2F1_20622854_ChIP-Seq_HELA_Human0.81823938
149OCT4_20526341_ChIP-Seq_ESCs_Human0.81460173
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.81312175
151SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81293906
152CTCF_27219007_Chip-Seq_Bcells_Human0.80924298
153NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80859310
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80504276
155PIAS1_25552417_ChIP-Seq_VCAP_Human0.79492790
156MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79171344
157ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78567942
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78386351
159TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78188507
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77552006
161ELF1_20517297_ChIP-Seq_JURKAT_Human0.77309261
162LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.76842348
163TP53_22127205_ChIP-Seq_IMR90_Human0.75951285
164ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75749702
165LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.75220664
166E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74681584
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74496559
168SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74376062
169PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73625048
170DCP1A_22483619_ChIP-Seq_HELA_Human0.73161184
171TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.73040369
172RARA_24833708_ChIP-Seq_LIVER_Mouse0.72939779
173SPI1_26923725_Chip-Seq_HPCs_Mouse0.72364012
174PHF8_20622854_ChIP-Seq_HELA_Human0.72305671
175CBX2_27304074_Chip-Seq_ESCs_Mouse0.71809458
176RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71333037
177SUZ12_27294783_Chip-Seq_NPCs_Mouse0.71149669
178ZNF263_19887448_ChIP-Seq_K562_Human0.70653522
179KLF4_19829295_ChIP-Seq_ESCs_Human0.70543832
180* P53_21459846_ChIP-Seq_SAOS-2_Human0.70492163
181* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.69991738
182* TCF4_23295773_ChIP-Seq_U87_Human0.69703979
183CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.69300857
184GF1_26923725_Chip-Seq_HPCs_Mouse0.68297697
185GABP_19822575_ChIP-Seq_HepG2_Human0.68291260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.90277496
2MP0005410_abnormal_fertilization8.54577530
3MP0001929_abnormal_gametogenesis5.07118280
4MP0008995_early_reproductive_senescence4.98775582
5MP0003698_abnormal_male_reproductive4.80509027
6MP0002210_abnormal_sex_determination4.76610965
7MP0003183_abnormal_peptide_metabolism4.23331102
8MP0001145_abnormal_male_reproductive3.94655833
9MP0005409_darkened_coat_color3.82993033
10MP0008057_abnormal_DNA_replication3.44936307
11MP0000653_abnormal_sex_gland3.44916131
12MP0003786_premature_aging3.19843543
13MP0010368_abnormal_lymphatic_system3.18353726
14MP0002089_abnormal_postnatal_growth/wei3.15386294
15MP0005167_abnormal_blood-brain_barrier3.04211447
16MP0004145_abnormal_muscle_electrophysio2.86935818
17MP0003878_abnormal_ear_physiology2.82108167
18MP0005377_hearing/vestibular/ear_phenot2.82108167
19MP0002161_abnormal_fertility/fecundity2.65954161
20MP0003136_yellow_coat_color2.55666652
21MP0010094_abnormal_chromosome_stability2.47132809
22MP0002735_abnormal_chemical_nociception2.42036684
23MP0002638_abnormal_pupillary_reflex2.37511837
24MP0008058_abnormal_DNA_repair2.28756888
25MP0001501_abnormal_sleep_pattern2.23824482
26MP0002249_abnormal_larynx_morphology2.19588086
27MP0001879_abnormal_lymphatic_vessel2.04134949
28MP0002160_abnormal_reproductive_system2.03604378
29MP0002653_abnormal_ependyma_morphology2.01817346
30MP0005645_abnormal_hypothalamus_physiol1.96506748
31MP0002733_abnormal_thermal_nociception1.90597806
32MP0006276_abnormal_autonomic_nervous1.89023422
33MP0002822_catalepsy1.81477139
34MP0002163_abnormal_gland_morphology1.76078153
35MP0003279_aneurysm1.71924703
36MP0000015_abnormal_ear_pigmentation1.69425485
37MP0005220_abnormal_exocrine_pancreas1.69248148
38MP0008007_abnormal_cellular_replicative1.63846055
39MP0003868_abnormal_feces_composition1.60701775
40MP0003111_abnormal_nucleus_morphology1.58485759
41MP0005623_abnormal_meninges_morphology1.55973459
42MP0005171_absent_coat_pigmentation1.53952420
43MP0005647_abnormal_sex_gland1.51677103
44MP0004381_abnormal_hair_follicle1.51113898
45MP0000372_irregular_coat_pigmentation1.47967089
46MP0000733_abnormal_muscle_development1.42973280
47MP0001970_abnormal_pain_threshold1.42303871
48MP0003705_abnormal_hypodermis_morpholog1.39034969
49MP0000678_abnormal_parathyroid_gland1.37904460
50MP0000470_abnormal_stomach_morphology1.31548439
51MP0003077_abnormal_cell_cycle1.31224981
52MP0002108_abnormal_muscle_morphology1.28589079
53MP0005174_abnormal_tail_pigmentation1.28050461
54MP0003123_paternal_imprinting1.27447236
55MP0002332_abnormal_exercise_endurance1.27257346
56MP0001727_abnormal_embryo_implantation1.24186561
57MP0000747_muscle_weakness1.22179564
58MP0001119_abnormal_female_reproductive1.21582553
59MP0003693_abnormal_embryo_hatching1.19790365
60MP0005389_reproductive_system_phenotype1.18038854
61MP0002928_abnormal_bile_duct1.17747029
62MP0003959_abnormal_lean_body1.11763733
63MP0003252_abnormal_bile_duct1.09985442
64MP0004808_abnormal_hematopoietic_stem1.09706831
65MP0009745_abnormal_behavioral_response1.08592543
66MP0010307_abnormal_tumor_latency1.08079860
67MP0002557_abnormal_social/conspecific_i1.05667137
68MP0003632_abnormal_nervous_system1.05521198
69MP0008872_abnormal_physiological_respon1.04634934
70MP0001730_embryonic_growth_arrest1.03748078
71MP0004957_abnormal_blastocyst_morpholog1.03714083
72MP0005379_endocrine/exocrine_gland_phen1.03075954
73MP0000371_diluted_coat_color1.02844831
74MP0003879_abnormal_hair_cell1.01792275
75MP0002067_abnormal_sensory_capabilities1.00476004
76MP0003646_muscle_fatigue0.98972884
77MP0001661_extended_life_span0.97729535
78MP0003699_abnormal_female_reproductive0.97114346
79MP0000569_abnormal_digit_pigmentation0.96578421
80MP0002734_abnormal_mechanical_nocicepti0.95472165
81MP0002909_abnormal_adrenal_gland0.95324686
82MP0009115_abnormal_fat_cell0.94037592
83MP0004142_abnormal_muscle_tone0.93361612
84MP0009278_abnormal_bone_marrow0.93269880
85MP0002272_abnormal_nervous_system0.90280341
86MP0005423_abnormal_somatic_nervous0.89217164
87MP0001486_abnormal_startle_reflex0.89135049
88MP0005503_abnormal_tendon_morphology0.87915807
89MP0003948_abnormal_gas_homeostasis0.87484886
90MP0005551_abnormal_eye_electrophysiolog0.87398875
91MP0003631_nervous_system_phenotype0.86080008
92MP0002138_abnormal_hepatobiliary_system0.83766406
93MP0002572_abnormal_emotion/affect_behav0.83277008
94MP0005076_abnormal_cell_differentiation0.82523292
95MP0005257_abnormal_intraocular_pressure0.81649382
96MP0002095_abnormal_skin_pigmentation0.81441953
97MP0003936_abnormal_reproductive_system0.81029611
98MP0005448_abnormal_energy_balance0.79528086
99MP0000427_abnormal_hair_cycle0.77943198
100MP0003633_abnormal_nervous_system0.77713981
101MP0005266_abnormal_metabolism0.77175438
102MP0002063_abnormal_learning/memory/cond0.76964000
103MP0000681_abnormal_thyroid_gland0.75718447
104MP0000759_abnormal_skeletal_muscle0.75651066
105MP0004134_abnormal_chest_morphology0.75230054
106MP0001485_abnormal_pinna_reflex0.74870341
107MP0001905_abnormal_dopamine_level0.74159347
108MP0003115_abnormal_respiratory_system0.73647933
109MP0001944_abnormal_pancreas_morphology0.73469198
110MP0000537_abnormal_urethra_morphology0.73248339
111MP0004130_abnormal_muscle_cell0.72774038
112MP0001664_abnormal_digestion0.70856198
113MP0004197_abnormal_fetal_growth/weight/0.69770406
114MP0002102_abnormal_ear_morphology0.69206605
115MP0001502_abnormal_circadian_rhythm0.68918366
116MP0002282_abnormal_trachea_morphology0.68325681
117MP0008932_abnormal_embryonic_tissue0.66862727
118MP0004085_abnormal_heartbeat0.66612738
119MP0003045_fibrosis0.66272939
120MP0004043_abnormal_pH_regulation0.65437481
121MP0002075_abnormal_coat/hair_pigmentati0.64818190
122MP0004233_abnormal_muscle_weight0.62988103
123MP0002084_abnormal_developmental_patter0.62262148
124MP0003315_abnormal_perineum_morphology0.62036483
125MP0000313_abnormal_cell_death0.60611909
126MP0003195_calcinosis0.59023306
127MP0001545_abnormal_hematopoietic_system0.58261889
128MP0005397_hematopoietic_system_phenotyp0.58261889
129MP0005380_embryogenesis_phenotype0.58211927
130MP0001672_abnormal_embryogenesis/_devel0.58211927
131MP0001697_abnormal_embryo_size0.56674934
132MP0000350_abnormal_cell_proliferation0.55418758
133MP0000358_abnormal_cell_content/0.52268400
134MP0003890_abnormal_embryonic-extraembry0.51836707
135MP0004084_abnormal_cardiac_muscle0.51461463
136MP0003984_embryonic_growth_retardation0.51369793
137MP0003121_genomic_imprinting0.50518399
138MP0002085_abnormal_embryonic_tissue0.50319901
139MP0002080_prenatal_lethality0.48444986
140MP0002088_abnormal_embryonic_growth/wei0.48116462
141MP0006138_congestive_heart_failure0.47860651
142MP0009672_abnormal_birth_weight0.47238059
143MP0004036_abnormal_muscle_relaxation0.47190995
144MP0000751_myopathy0.45121134
145MP0003787_abnormal_imprinting0.44458107
146MP0005670_abnormal_white_adipose0.43997431
147MP0000647_abnormal_sebaceous_gland0.42873648
148MP0009703_decreased_birth_body0.40780489
149MP0004742_abnormal_vestibular_system0.40709944
150MP0002086_abnormal_extraembryonic_tissu0.40099454
151MP0009046_muscle_twitch0.35079365
152MP0001293_anophthalmia0.34816723
153MP0001919_abnormal_reproductive_system0.33829003
154MP0000639_abnormal_adrenal_gland0.32490034
155MP0008961_abnormal_basal_metabolism0.30881927
156MP0003942_abnormal_urinary_system0.30840097
157MP0001440_abnormal_grooming_behavior0.30430111
158MP0002019_abnormal_tumor_incidence0.30106491
159MP0003861_abnormal_nervous_system0.29680086
160MP0002092_abnormal_eye_morphology0.28826694
161MP0002009_preneoplasia0.27923099
162MP0002168_other_aberrant_phenotype0.27023691
163MP0001915_intracranial_hemorrhage0.26525986
164MP0005395_other_phenotype0.26372015
165MP0005391_vision/eye_phenotype0.25997846
166MP0003718_maternal_effect0.24909812
167MP0004272_abnormal_basement_membrane0.24443203
168MP0000428_abnormal_craniofacial_morphol0.23727386
169MP0002269_muscular_atrophy0.23574859
170MP0004885_abnormal_endolymph0.23058036
171MP0001984_abnormal_olfaction0.22682175
172MP0001851_eye_inflammation0.21310327
173MP0005384_cellular_phenotype0.20439875

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.35458962
2Absent/shortened dynein arms (HP:0200106)9.35458962
3Genetic anticipation (HP:0003743)8.97173384
4Abnormal respiratory motile cilium physiology (HP:0012261)7.08884154
5Gonadotropin excess (HP:0000837)6.75416259
6Rhinitis (HP:0012384)6.58035761
7Azoospermia (HP:0000027)6.49109242
8Abnormal respiratory epithelium morphology (HP:0012253)6.44007255
9Abnormal respiratory motile cilium morphology (HP:0005938)6.44007255
10Abnormal spermatogenesis (HP:0008669)5.93226805
11Abnormality of the lower motor neuron (HP:0002366)5.84338119
12Infertility (HP:0000789)5.60833415
13Abnormal ciliary motility (HP:0012262)5.53021893
14Chronic bronchitis (HP:0004469)5.52303065
15Progressive cerebellar ataxia (HP:0002073)4.98971387
16Nasal polyposis (HP:0100582)4.84543120
1711 pairs of ribs (HP:0000878)4.67587856
18Male infertility (HP:0003251)4.63967241
19Abnormality of the fingertips (HP:0001211)4.46900646
20Nephronophthisis (HP:0000090)4.27105738
21Abnormality of the columella (HP:0009929)4.09398006
22Fibular hypoplasia (HP:0003038)4.05763569
23Vertebral arch anomaly (HP:0008438)4.00321181
24Amyotrophic lateral sclerosis (HP:0007354)3.97358885
25Abnormality of the nasal mucosa (HP:0000433)3.91666156
26Neoplasm of the heart (HP:0100544)3.81537517
27Diplopia (HP:0000651)3.80695037
28Abnormality of binocular vision (HP:0011514)3.80695037
29Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.71872995
30Bronchiectasis (HP:0002110)3.62336322
31Lip pit (HP:0100267)3.53744489
32Obstructive sleep apnea (HP:0002870)3.47118260
33Gaze-evoked nystagmus (HP:0000640)3.35227503
34Hyperventilation (HP:0002883)3.34866736
35Short 4th metacarpal (HP:0010044)3.33851711
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33851711
37Bronchitis (HP:0012387)3.32124337
38Visual hallucinations (HP:0002367)3.24094586
39Urethral obstruction (HP:0000796)3.17322493
40Abnormality of the renal medulla (HP:0100957)3.15551020
41Upper motor neuron abnormality (HP:0002127)3.15419684
42Long eyelashes (HP:0000527)3.13896161
43Deformed sella turcica (HP:0002681)3.08212986
44Impaired smooth pursuit (HP:0007772)3.06120126
45Dysmetric saccades (HP:0000641)2.99899356
46Degeneration of anterior horn cells (HP:0002398)2.94252417
47Abnormality of the anterior horn cell (HP:0006802)2.94252417
48Tubulointerstitial nephritis (HP:0001970)2.89010694
49Flat acetabular roof (HP:0003180)2.81029549
50Palpebral edema (HP:0100540)2.80562155
51Selective tooth agenesis (HP:0001592)2.80164047
52Abnormality of the sella turcica (HP:0002679)2.79804116
53Duplicated collecting system (HP:0000081)2.75744903
54Abnormality of the renal collecting system (HP:0004742)2.71363276
55Blue irides (HP:0000635)2.70560067
56Hypoplastic ischia (HP:0003175)2.69842527
57Cerebral aneurysm (HP:0004944)2.65936614
58Broad ribs (HP:0000885)2.63930020
59Missing ribs (HP:0000921)2.62915194
60Supernumerary ribs (HP:0005815)2.59430109
61Hyperkalemia (HP:0002153)2.58922488
62Impulsivity (HP:0100710)2.56718237
63Spontaneous abortion (HP:0005268)2.56633265
64Broad face (HP:0000283)2.56592906
65Aplasia/Hypoplasia of the fibula (HP:0006492)2.56170177
66Tubular atrophy (HP:0000092)2.52197164
67Abnormality of the ischium (HP:0003174)2.50010063
68Gonadal dysgenesis (HP:0000133)2.49550444
69Truncal obesity (HP:0001956)2.48658320
70Recurrent otitis media (HP:0000403)2.48602086
71Stage 5 chronic kidney disease (HP:0003774)2.47164840
72Abnormality of the parietal bone (HP:0002696)2.44394583
73Congenital stationary night blindness (HP:0007642)2.42500574
74Impaired proprioception (HP:0010831)2.42047543
75Hand muscle atrophy (HP:0009130)2.41718809
76Narrow palate (HP:0000189)2.39527037
77Abnormality of the pubic bones (HP:0003172)2.35293657
78Absent frontal sinuses (HP:0002688)2.35159736
79Stereotypic behavior (HP:0000733)2.33690766
80Short phalanx of the thumb (HP:0009660)2.32887639
81Supernumerary bones of the axial skeleton (HP:0009144)2.31592423
82Urinary bladder sphincter dysfunction (HP:0002839)2.29863387
83Microglossia (HP:0000171)2.29367092
84Abnormality of midbrain morphology (HP:0002418)2.29185595
85Molar tooth sign on MRI (HP:0002419)2.29185595
86Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.28912672
87Flared iliac wings (HP:0002869)2.28419322
88Tubulointerstitial abnormality (HP:0001969)2.27082339
89Laryngomalacia (HP:0001601)2.26262738
90Mask-like facies (HP:0000298)2.26029102
91Abnormality of the 4th metacarpal (HP:0010012)2.24936619
92Recurrent sinusitis (HP:0011108)2.24119057
93Spinal muscular atrophy (HP:0007269)2.23980859
94Depressed nasal tip (HP:0000437)2.22828960
95Diastasis recti (HP:0001540)2.21014901
96Postaxial foot polydactyly (HP:0001830)2.16800509
97Large eyes (HP:0001090)2.13379539
98Hypoplasia of the iris (HP:0007676)2.10758808
99Male pseudohermaphroditism (HP:0000037)2.10598118
100Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10472206
101Short ribs (HP:0000773)2.09785930
102Hemiplegia (HP:0002301)2.09785522
103Abnormality of the nasal septum (HP:0000419)2.08236649
104Conjunctival telangiectasia (HP:0000524)2.07436745
105Supernumerary spleens (HP:0009799)2.06329456
106Heterotopia (HP:0002282)2.06307955
107Facial cleft (HP:0002006)2.05981221
108Protruding tongue (HP:0010808)2.04746516
109Breast carcinoma (HP:0003002)2.02990243
110Down-sloping shoulders (HP:0200021)2.01282112
111Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.4606486
112Facial diplegia (HP:0001349)1.99776476
113Renovascular hypertension (HP:0100817)1.99526114
114Hypoplastic iliac wings (HP:0002866)1.97353211
115Portal hypertension (HP:0001409)1.96049129
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95888309
117Oligodontia (HP:0000677)1.95808961
118Ureteral obstruction (HP:0006000)1.95289029
119Abnormality of dentin (HP:0010299)1.93773967
120Autoimmune thrombocytopenia (HP:0001973)1.90039693
121Aplasia/Hypoplasia of the fovea (HP:0008060)1.89128909
122Hypoplasia of the fovea (HP:0007750)1.89128909
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.88681292
124Tongue fasciculations (HP:0001308)1.87969578
125Subaortic stenosis (HP:0001682)1.86707462
126Abnormality of the left ventricular outflow tract (HP:0011103)1.86707462
127Ureteral stenosis (HP:0000071)1.86269914
128Thoracic kyphosis (HP:0002942)1.85873145
129Recurrent bronchitis (HP:0002837)1.85338518
130Medial flaring of the eyebrow (HP:0010747)1.85302218
131Median cleft lip (HP:0000161)1.85173039
132Clonus (HP:0002169)1.82955588
133Oculomotor apraxia (HP:0000657)1.81201216
134Upper limb amyotrophy (HP:0009129)1.81171935
135Distal upper limb amyotrophy (HP:0007149)1.81171935
136Natal tooth (HP:0000695)1.80878805
137Nephroblastoma (Wilms tumor) (HP:0002667)1.78542572
138Postural instability (HP:0002172)1.78388546
139Abnormality of the hepatic vasculature (HP:0006707)1.78086637
140Renal dysplasia (HP:0000110)1.75505102
141Hypoplastic nipples (HP:0002557)1.75351020
142J-shaped sella turcica (HP:0002680)1.75191309
143Bell-shaped thorax (HP:0001591)1.73984340
144Tented upper lip vermilion (HP:0010804)1.73923348
145Chronic hepatic failure (HP:0100626)1.72959162
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.72747325
147Thoracolumbar scoliosis (HP:0002944)1.72486523
148Decreased circulating renin level (HP:0003351)1.71925645
149Short thorax (HP:0010306)1.71352679
150Severe visual impairment (HP:0001141)1.70015797
151Periorbital edema (HP:0100539)1.69479221
152Self-mutilation (HP:0000742)1.69475140
153Metaphyseal cupping (HP:0003021)1.67439561
154Dysautonomia (HP:0002459)1.67310585
155Muscle fibrillation (HP:0010546)1.67039924
156Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.66364355
157Macroorchidism (HP:0000053)1.65568168
158Underdeveloped nasal alae (HP:0000430)1.65278847
159Abnormality of the aortic arch (HP:0012303)1.65020835
160Ectopic kidney (HP:0000086)1.63739699
161Aplasia/Hypoplasia of the macula (HP:0008059)1.63536586
162Absent epiphyses (HP:0010577)1.63341358
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63341358
164Prominent nose (HP:0000448)1.63338531
165Narrow nasal bridge (HP:0000446)1.63113853
166Tubulointerstitial fibrosis (HP:0005576)1.62761111
167Embryonal renal neoplasm (HP:0011794)1.62684261
168Carpal bone hypoplasia (HP:0001498)1.62581138
169Sparse lateral eyebrow (HP:0005338)1.61776089
170Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.61617804
171Abnormality of the thoracic spine (HP:0100711)1.61407436
172Truncal ataxia (HP:0002078)1.60969050
173Congenital hepatic fibrosis (HP:0002612)1.60892692
174Difficulty climbing stairs (HP:0003551)1.58969518
175Occipital encephalocele (HP:0002085)1.58659025
176Papillary thyroid carcinoma (HP:0002895)1.57434272
177Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57042008
178Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56892313
179Dislocated radial head (HP:0003083)1.56174771
180Abnormality of ocular smooth pursuit (HP:0000617)1.54821008
181Broad distal phalanx of finger (HP:0009836)1.54608473
182Ankle clonus (HP:0011448)1.53434112
183Hyporeflexia of lower limbs (HP:0002600)1.53002266
184Spastic tetraparesis (HP:0001285)1.52629139
185Abnormality of the epiphyses of the hand (HP:0005924)1.49157211
186Abnormality of the vasculature of the conjunctiva (HP:0008054)1.48634938
187Ridged nail (HP:0001807)1.47381156
188Abnormality of the renal cortex (HP:0011035)1.46810865
189Postaxial hand polydactyly (HP:0001162)1.44509783
190Abnormality of the musculature of the hand (HP:0001421)1.44451787
191Abnormality of the radial head (HP:0003995)1.44140478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.57941505
2PDK48.57941505
3INSRR5.95399292
4PDK25.44063155
5FRK4.53008584
6CAMK1D3.13766176
7CDK122.90862809
8TESK12.84283606
9ICK2.81054706
10SIK22.73059783
11CDC72.63324762
12PRKD32.62197956
13NEK22.47423476
14PRPF4B2.23640099
15WNK42.20520283
16PTK2B2.14721124
17PNCK2.08575287
18BLK1.93206997
19CAMKK11.89867358
20MAP3K71.79258042
21CAMK41.79054308
22WEE11.77832302
23TIE11.76820592
24TYRO31.75778253
25STK391.74843741
26MARK21.69333869
27SGK21.61198409
28ACVR1B1.53280762
29STK31.48371913
30WNK11.42219943
31SGK4941.30996814
32SGK2231.30996814
33NTRK31.29487385
34CASK1.22760619
35ATR1.17095956
36PRKCH1.16872094
37TNK21.15059608
38GRK11.12303735
39TTK1.07753917
40BRD41.04306053
41CHEK11.02750488
42WNK30.93954113
43SGK30.93050695
44SGK10.92202045
45CAMK10.91611183
46MAPK150.88177760
47PLK10.87627810
48RPS6KA60.87417730
49CCNB10.86205536
50FGFR30.85225356
51CHUK0.84920158
52PLK40.83557502
53PASK0.80139447
54CDK70.78758571
55BUB10.78017280
56PRKAA20.75242455
57ERBB20.73202410
58MTOR0.73126330
59MAP3K20.72369607
60IRAK20.71556396
61MAP3K40.71417146
62RPS6KC10.71099168
63RPS6KL10.71099168
64ATM0.70895421
65FGFR20.70672865
66STK380.70636750
67MAPK70.70491601
68FES0.69715326
69RPS6KA20.68378363
70CDK80.66412135
71MST1R0.65897568
72MAPK110.65410953
73CHEK20.63911230
74HIPK20.63569322
75STK38L0.63345062
76CAMKK20.62070301
77CDK90.59951991
78ADRBK10.59779811
79KIT0.59316738
80EEF2K0.58432919
81DDR20.58242938
82DYRK30.56232229
83TAOK30.55934737
84NLK0.55049122
85LMTK20.53385792
86AKT30.53161094
87FER0.52940196
88PDK10.51923306
89PINK10.51898191
90BRSK20.51363023
91RPS6KA50.50255586
92TRIB30.50148244
93BMPR1B0.50091636
94CAMK1G0.49842643
95IRAK10.47783183
96TGFBR20.47164852
97PRKD20.46453394
98CDK40.46181401
99RPS6KA10.45638502
100DYRK1B0.43508879
101MAP3K10.42899140
102MAPKAPK20.40996254
103ZAK0.39985678
104SRPK10.39953216
105GRK70.38619513
106CDK30.38188861
107CDK20.37588134
108SIK10.37352071
109OBSCN0.37161279
110PAK20.37109951
111TLK10.36289304
112RET0.36003272
113CDK10.35074212
114MAP2K60.33550114
115DAPK20.33227880
116TGFBR10.32035610
117RIPK10.31505766
118PAK40.29310242
119KDR0.29116137
120PDGFRB0.29025647
121PTK60.28048797
122AURKB0.25433784
123STK40.24977908
124PRKDC0.24927883
125PRKAA10.23592991
126BRSK10.23438675
127PLK30.21648646
128PAK10.20526538
129RPS6KB10.19123571
130GSK3B0.18598670
131PAK60.16677568
132MAPK80.16434685
133PRKACB0.15407561
134CDC42BPA0.15093422
135MARK30.14304732
136LATS10.13303075
137MAPK100.13103577
138MKNK20.12853571
139NEK10.12278817
140STK240.11567817
141EGFR0.11227388
142EPHB10.11018190
143CSNK1D0.10565453
144CSNK2A10.10019048
145CSNK2A20.09713870
146CSNK1E0.09541498
147MAPK10.09507642
148MAPK140.09240607
149TAOK10.08443006
150PKN20.07273348
151STK110.05894868
152MET0.05631881
153MAP2K70.05576082
154NTRK20.05270836
155PDGFRA0.04516523
156TESK20.04188265
157AURKA0.03933547
158PRKCG0.03035832
159EIF2AK10.02994826
160CDK60.02730488
161RPS6KA30.02569539
162MELK0.02375602
163AKT10.02246809
164PLK20.01802373
165MAP3K100.00688435

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043204.31081385
2Basal transcription factors_Homo sapiens_hsa030224.12138072
3Vitamin B6 metabolism_Homo sapiens_hsa007503.74351872
4Fanconi anemia pathway_Homo sapiens_hsa034603.29800063
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27516420
6Pyruvate metabolism_Homo sapiens_hsa006203.20822766
7RNA transport_Homo sapiens_hsa030133.06872484
8Homologous recombination_Homo sapiens_hsa034402.87758243
9mRNA surveillance pathway_Homo sapiens_hsa030152.85960097
10Selenocompound metabolism_Homo sapiens_hsa004502.81179477
11Pentose phosphate pathway_Homo sapiens_hsa000302.68480598
12Oocyte meiosis_Homo sapiens_hsa041142.65519785
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.28230120
14Notch signaling pathway_Homo sapiens_hsa043302.27702260
15Cell cycle_Homo sapiens_hsa041102.11479364
16Fatty acid biosynthesis_Homo sapiens_hsa000612.08634440
17Propanoate metabolism_Homo sapiens_hsa006402.00354569
18Taste transduction_Homo sapiens_hsa047421.97113202
19Nicotine addiction_Homo sapiens_hsa050331.92056464
20Type II diabetes mellitus_Homo sapiens_hsa049301.90311323
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.89771719
22Glucagon signaling pathway_Homo sapiens_hsa049221.89647005
23Morphine addiction_Homo sapiens_hsa050321.78525920
24Glutamatergic synapse_Homo sapiens_hsa047241.72407744
25Glycerolipid metabolism_Homo sapiens_hsa005611.72185435
26GABAergic synapse_Homo sapiens_hsa047271.69522516
27Cholinergic synapse_Homo sapiens_hsa047251.69166106
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67623080
29Spliceosome_Homo sapiens_hsa030401.59352977
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.56429188
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54449922
32Circadian entrainment_Homo sapiens_hsa047131.52855791
33Antigen processing and presentation_Homo sapiens_hsa046121.51968228
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51795977
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49709444
36Oxytocin signaling pathway_Homo sapiens_hsa049211.40863375
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.39842921
38Nucleotide excision repair_Homo sapiens_hsa034201.37342855
39Linoleic acid metabolism_Homo sapiens_hsa005911.37276169
40Caffeine metabolism_Homo sapiens_hsa002321.36796694
41Calcium signaling pathway_Homo sapiens_hsa040201.35255246
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31755393
43DNA replication_Homo sapiens_hsa030301.31284221
44Serotonergic synapse_Homo sapiens_hsa047261.30928808
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29469939
46RNA degradation_Homo sapiens_hsa030181.23092780
47Alcoholism_Homo sapiens_hsa050341.22998003
48Ovarian steroidogenesis_Homo sapiens_hsa049131.21240693
49Proteasome_Homo sapiens_hsa030501.17588248
50Mismatch repair_Homo sapiens_hsa034301.17444155
51Huntingtons disease_Homo sapiens_hsa050161.17129826
52Glycerophospholipid metabolism_Homo sapiens_hsa005641.15086598
53Lysine degradation_Homo sapiens_hsa003101.13781677
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.13588992
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.11071065
56Axon guidance_Homo sapiens_hsa043601.04577808
57MicroRNAs in cancer_Homo sapiens_hsa052061.03313940
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01808574
59Biosynthesis of amino acids_Homo sapiens_hsa012301.00627381
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00117538
61Cocaine addiction_Homo sapiens_hsa050301.00021707
62Bile secretion_Homo sapiens_hsa049761.00012070
63Circadian rhythm_Homo sapiens_hsa047100.99213018
64Vitamin digestion and absorption_Homo sapiens_hsa049770.98469347
65Purine metabolism_Homo sapiens_hsa002300.97478964
66Carbon metabolism_Homo sapiens_hsa012000.97295769
67Insulin secretion_Homo sapiens_hsa049110.96275587
68Gastric acid secretion_Homo sapiens_hsa049710.96213300
69Phototransduction_Homo sapiens_hsa047440.95916496
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95051101
71GnRH signaling pathway_Homo sapiens_hsa049120.92278704
72RNA polymerase_Homo sapiens_hsa030200.91353148
73Base excision repair_Homo sapiens_hsa034100.91271155
74Fatty acid metabolism_Homo sapiens_hsa012120.89607434
75Dopaminergic synapse_Homo sapiens_hsa047280.88916984
76cAMP signaling pathway_Homo sapiens_hsa040240.87504402
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.86405990
78Salivary secretion_Homo sapiens_hsa049700.85898949
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85261206
80p53 signaling pathway_Homo sapiens_hsa041150.84971106
81B cell receptor signaling pathway_Homo sapiens_hsa046620.84835750
82Choline metabolism in cancer_Homo sapiens_hsa052310.84655392
83Glioma_Homo sapiens_hsa052140.84373246
84MAPK signaling pathway_Homo sapiens_hsa040100.83720472
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83064206
86Platelet activation_Homo sapiens_hsa046110.80793599
87Renal cell carcinoma_Homo sapiens_hsa052110.79928008
88PPAR signaling pathway_Homo sapiens_hsa033200.78987445
89Melanogenesis_Homo sapiens_hsa049160.78839366
90Renin secretion_Homo sapiens_hsa049240.78590579
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.77315926
92Phenylalanine metabolism_Homo sapiens_hsa003600.75971425
93Herpes simplex infection_Homo sapiens_hsa051680.75854453
94Insulin resistance_Homo sapiens_hsa049310.74299864
95FoxO signaling pathway_Homo sapiens_hsa040680.74249912
96Prostate cancer_Homo sapiens_hsa052150.73990286
97Long-term depression_Homo sapiens_hsa047300.73613357
98Pyrimidine metabolism_Homo sapiens_hsa002400.72739569
99Epstein-Barr virus infection_Homo sapiens_hsa051690.71787060
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70878222
101Dilated cardiomyopathy_Homo sapiens_hsa054140.70837478
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70415998
103Focal adhesion_Homo sapiens_hsa045100.67962081
104Gap junction_Homo sapiens_hsa045400.67525866
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67155982
106ErbB signaling pathway_Homo sapiens_hsa040120.66811233
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66298818
108Amphetamine addiction_Homo sapiens_hsa050310.65920852
109Prolactin signaling pathway_Homo sapiens_hsa049170.65140669
110Estrogen signaling pathway_Homo sapiens_hsa049150.65104519
111Adherens junction_Homo sapiens_hsa045200.63610225
112HTLV-I infection_Homo sapiens_hsa051660.63289910
113Fat digestion and absorption_Homo sapiens_hsa049750.63154586
114Mineral absorption_Homo sapiens_hsa049780.62105763
115T cell receptor signaling pathway_Homo sapiens_hsa046600.61691282
116Influenza A_Homo sapiens_hsa051640.61474795
117Non-small cell lung cancer_Homo sapiens_hsa052230.60460818
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60139025
119Small cell lung cancer_Homo sapiens_hsa052220.60120670
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59415713
121Non-homologous end-joining_Homo sapiens_hsa034500.58681404
122Chronic myeloid leukemia_Homo sapiens_hsa052200.58254691
123N-Glycan biosynthesis_Homo sapiens_hsa005100.57978309
124Hedgehog signaling pathway_Homo sapiens_hsa043400.57865454
125Retinol metabolism_Homo sapiens_hsa008300.57339041
126Viral carcinogenesis_Homo sapiens_hsa052030.56841216
127Olfactory transduction_Homo sapiens_hsa047400.55789916
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53221282
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.52900058
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.51476489
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51292501
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50793526
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50788563
134VEGF signaling pathway_Homo sapiens_hsa043700.50395436
135Ras signaling pathway_Homo sapiens_hsa040140.48914716
136Osteoclast differentiation_Homo sapiens_hsa043800.48780878
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47140048
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44615670
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.44433637
140Ether lipid metabolism_Homo sapiens_hsa005650.41947655
141ECM-receptor interaction_Homo sapiens_hsa045120.40073449
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40053624
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.39945382
144TGF-beta signaling pathway_Homo sapiens_hsa043500.39543700
145Fatty acid degradation_Homo sapiens_hsa000710.36061202
146Inositol phosphate metabolism_Homo sapiens_hsa005620.35908839
147ABC transporters_Homo sapiens_hsa020100.35527234
148AMPK signaling pathway_Homo sapiens_hsa041520.34912895
149Legionellosis_Homo sapiens_hsa051340.34790430
150Long-term potentiation_Homo sapiens_hsa047200.33669940
151Toxoplasmosis_Homo sapiens_hsa051450.31419443
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31320825
153Tight junction_Homo sapiens_hsa045300.30123837
154Cardiac muscle contraction_Homo sapiens_hsa042600.29391798
155Wnt signaling pathway_Homo sapiens_hsa043100.28165195
156Endocytosis_Homo sapiens_hsa041440.27610186
157Basal cell carcinoma_Homo sapiens_hsa052170.27587724
158Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27336625
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26921233
160Protein digestion and absorption_Homo sapiens_hsa049740.26706616
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24228787
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.24173024
163Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24066460
164Amoebiasis_Homo sapiens_hsa051460.23854678
165Fructose and mannose metabolism_Homo sapiens_hsa000510.23712926
166Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19109702
167Sphingolipid metabolism_Homo sapiens_hsa006000.17682578
168Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17579314
169Systemic lupus erythematosus_Homo sapiens_hsa053220.14087585
170Vascular smooth muscle contraction_Homo sapiens_hsa042700.13760991
171Renin-angiotensin system_Homo sapiens_hsa046140.11684895
172mTOR signaling pathway_Homo sapiens_hsa041500.11682372
173Complement and coagulation cascades_Homo sapiens_hsa046100.11339384

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