TEX11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* synaptonemal complex assembly (GO:0007130)9.49911422
2DNA methylation involved in gamete generation (GO:0043046)9.04519548
3regulation of meiosis I (GO:0060631)8.70264016
4* synaptonemal complex organization (GO:0070193)8.64055606
5synapsis (GO:0007129)8.51953843
6male meiosis (GO:0007140)8.09568781
7meiotic nuclear division (GO:0007126)7.06636587
8male meiosis I (GO:0007141)6.59839593
9* chromosome organization involved in meiosis (GO:0070192)6.43382473
10attachment of spindle microtubules to kinetochore (GO:0008608)5.80017600
11meiosis I (GO:0007127)5.78384152
12behavioral response to nicotine (GO:0035095)5.63118188
13DNA synthesis involved in DNA repair (GO:0000731)5.58210138
14nuclear pore complex assembly (GO:0051292)5.40491459
15nuclear pore organization (GO:0006999)5.36910363
16* meiotic cell cycle process (GO:1903046)5.28444795
17negative regulation of meiosis (GO:0045835)5.24011589
18mitotic metaphase plate congression (GO:0007080)5.11976952
19sister chromatid cohesion (GO:0007062)4.97713393
20positive regulation of meiosis (GO:0045836)4.97621429
21cilium or flagellum-dependent cell motility (GO:0001539)4.90351435
22gene silencing by RNA (GO:0031047)4.86593430
23DNA alkylation (GO:0006305)4.86566645
24DNA methylation (GO:0006306)4.86566645
25chromatin remodeling at centromere (GO:0031055)4.85961143
26DNA replication checkpoint (GO:0000076)4.77373571
27positive regulation of meiotic cell cycle (GO:0051446)4.71319441
28metaphase plate congression (GO:0051310)4.67832618
29mitotic chromosome condensation (GO:0007076)4.67086488
30oogenesis (GO:0048477)4.66438970
31oocyte maturation (GO:0001556)4.64586315
32protein K6-linked ubiquitination (GO:0085020)4.54408027
33* reciprocal meiotic recombination (GO:0007131)4.44526979
34* reciprocal DNA recombination (GO:0035825)4.44526979
35histone exchange (GO:0043486)4.43558468
36kinetochore organization (GO:0051383)4.39104869
37DNA replication-dependent nucleosome organization (GO:0034723)4.30595443
38DNA replication-dependent nucleosome assembly (GO:0006335)4.30595443
39CENP-A containing nucleosome assembly (GO:0034080)4.27365697
40organic cation transport (GO:0015695)4.25899291
41female gamete generation (GO:0007292)4.22134303
42kinetochore assembly (GO:0051382)4.17542189
43gonadal mesoderm development (GO:0007506)4.17386254
44DNA replication-independent nucleosome organization (GO:0034724)4.16887412
45DNA replication-independent nucleosome assembly (GO:0006336)4.16887412
46regulation of meiosis (GO:0040020)4.14954073
47negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.11442473
48heterochromatin organization (GO:0070828)4.10616359
49microtubule depolymerization (GO:0007019)4.10093354
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.04754695
51regulation of double-strand break repair via homologous recombination (GO:0010569)3.98087390
52pore complex assembly (GO:0046931)3.94563463
53* meiotic chromosome segregation (GO:0045132)3.94441760
54positive regulation of translational initiation (GO:0045948)3.85974526
55regulation of chromosome segregation (GO:0051983)3.78021888
56DNA methylation or demethylation (GO:0044728)3.74791311
57mitotic nuclear envelope disassembly (GO:0007077)3.71876754
58establishment of chromosome localization (GO:0051303)3.68641257
59spindle checkpoint (GO:0031577)3.66058290
60protein localization to kinetochore (GO:0034501)3.65321755
61gene silencing (GO:0016458)3.65020233
62histone H4-K12 acetylation (GO:0043983)3.63645768
63mitotic sister chromatid cohesion (GO:0007064)3.63455449
64mitotic spindle checkpoint (GO:0071174)3.61998837
65meiotic cell cycle (GO:0051321)3.60654962
66mitotic spindle assembly checkpoint (GO:0007094)3.59706755
67spindle assembly checkpoint (GO:0071173)3.57766610
68oocyte development (GO:0048599)3.55321154
69negative regulation of chromosome segregation (GO:0051985)3.55254769
70regulation of sister chromatid cohesion (GO:0007063)3.54426195
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.51910067
72negative regulation of sister chromatid segregation (GO:0033046)3.51910067
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.51910067
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.51910067
75membrane disassembly (GO:0030397)3.51622525
76nuclear envelope disassembly (GO:0051081)3.51622525
77protein localization to chromosome (GO:0034502)3.49536981
78regulation of mitotic metaphase/anaphase transition (GO:0030071)3.49073486
79positive regulation of chromosome segregation (GO:0051984)3.47344650
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.47119069
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.45435819
82mitotic sister chromatid segregation (GO:0000070)3.44319394
83nuclear division (GO:0000280)3.40384756
84chromatin assembly or disassembly (GO:0006333)3.39315028
85regulation of mitotic sister chromatid separation (GO:0010965)3.37784806
86regulation of mitotic sister chromatid segregation (GO:0033047)3.37784806
87regulation of sister chromatid segregation (GO:0033045)3.37784806
88protein localization to chromosome, centromeric region (GO:0071459)3.35579379
89exogenous drug catabolic process (GO:0042738)3.35233638
90DNA replication initiation (GO:0006270)3.34523555
91inner cell mass cell proliferation (GO:0001833)3.34079073
92negative regulation of nuclear division (GO:0051784)3.33420073
93regulation of meiotic cell cycle (GO:0051445)3.33079326
94negative regulation of telomere maintenance (GO:0032205)3.32813858
95* chromosome organization (GO:0051276)3.32710582
96regulation of spindle organization (GO:0090224)3.29060595
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.27185245
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.27185245
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.27185245
100protein K11-linked deubiquitination (GO:0035871)3.25749933
101regulation of double-strand break repair (GO:2000779)3.24574887
102* chromosome segregation (GO:0007059)3.21743158
103protein polyglutamylation (GO:0018095)3.20107675
104regulation of retinoic acid receptor signaling pathway (GO:0048385)3.18937711
105negative regulation of meiotic cell cycle (GO:0051447)3.18926414
106* resolution of meiotic recombination intermediates (GO:0000712)3.18737121
107monoubiquitinated protein deubiquitination (GO:0035520)3.18694403
108regulation of centriole replication (GO:0046599)3.17566032
109regulation of helicase activity (GO:0051095)3.17244709
110cellular ketone body metabolic process (GO:0046950)3.15503960
111drug transmembrane transport (GO:0006855)3.10006086
112DNA modification (GO:0006304)3.08789892
113neurotransmitter metabolic process (GO:0042133)3.05910581
114detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01570835
115detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.98539234
116sex differentiation (GO:0007548)2.93585643
117L-fucose catabolic process (GO:0042355)2.93341180
118fucose catabolic process (GO:0019317)2.93341180
119L-fucose metabolic process (GO:0042354)2.93341180
120centriole assembly (GO:0098534)2.84809465
121macroautophagy (GO:0016236)2.83713315
122nephron tubule morphogenesis (GO:0072078)2.82726369
123nephron epithelium morphogenesis (GO:0072088)2.82726369
124ketone body metabolic process (GO:1902224)2.82407772
125epithelial cilium movement (GO:0003351)2.80392371
126drug catabolic process (GO:0042737)2.74859638
127acrosome reaction (GO:0007340)2.74202381
128kynurenine metabolic process (GO:0070189)2.73374115
129negative regulation of DNA-dependent DNA replication (GO:2000104)2.72056467
130quaternary ammonium group transport (GO:0015697)2.70667426
131indolalkylamine metabolic process (GO:0006586)2.70488624
132rRNA catabolic process (GO:0016075)2.69830160
133ubiquinone biosynthetic process (GO:0006744)2.69827400
134axoneme assembly (GO:0035082)2.68218529
135spermatid development (GO:0007286)2.67139345
136DNA deamination (GO:0045006)2.66767497
137photoreceptor cell maintenance (GO:0045494)2.66293208
138tryptophan catabolic process (GO:0006569)2.64194212
139indole-containing compound catabolic process (GO:0042436)2.64194212
140indolalkylamine catabolic process (GO:0046218)2.64194212
141negative regulation of mast cell activation (GO:0033004)2.62706065
142neurotransmitter biosynthetic process (GO:0042136)2.62233334
143primary amino compound metabolic process (GO:1901160)2.58002961
144regulation of microtubule-based movement (GO:0060632)2.56484938
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55564498
146synaptic transmission, cholinergic (GO:0007271)2.55443737
147maturation of 5.8S rRNA (GO:0000460)2.54431435
148regulation of posttranscriptional gene silencing (GO:0060147)2.53424142
149regulation of gene silencing by miRNA (GO:0060964)2.53424142
150regulation of gene silencing by RNA (GO:0060966)2.53424142
151mitochondrion morphogenesis (GO:0070584)2.53169768
152centriole replication (GO:0007099)2.52020816
153ubiquinone metabolic process (GO:0006743)2.51556076
154sperm motility (GO:0030317)2.51437859
155mitochondrial respiratory chain complex I assembly (GO:0032981)2.49679939
156NADH dehydrogenase complex assembly (GO:0010257)2.49679939
157mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49679939
158regulation of mitotic spindle checkpoint (GO:1903504)2.49317541
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.49317541
160regulation of DNA endoreduplication (GO:0032875)2.48998618
161S-adenosylmethionine metabolic process (GO:0046500)2.48386081
162detection of light stimulus involved in visual perception (GO:0050908)2.47185572
163detection of light stimulus involved in sensory perception (GO:0050962)2.47185572
164iron-sulfur cluster assembly (GO:0016226)2.46920679
165metallo-sulfur cluster assembly (GO:0031163)2.46920679
166regulation of nuclear cell cycle DNA replication (GO:0033262)2.45890161
167hindbrain development (GO:0030902)2.42901220
168cilium movement (GO:0003341)2.40518135
169nonmotile primary cilium assembly (GO:0035058)2.39868430
170negative regulation of epidermal cell differentiation (GO:0045605)2.39350844
171myelin assembly (GO:0032288)2.38199825
172piRNA metabolic process (GO:0034587)11.5518842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.75130147
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.79478705
3EZH2_22144423_ChIP-Seq_EOC_Human5.48107814
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.92817819
5ZNF274_21170338_ChIP-Seq_K562_Hela4.56772848
6E2F4_17652178_ChIP-ChIP_JURKAT_Human4.39424292
7IGF1R_20145208_ChIP-Seq_DFB_Human4.02359851
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.93554728
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.88334099
10AR_21909140_ChIP-Seq_LNCAP_Human3.44098673
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.31277420
12VDR_22108803_ChIP-Seq_LS180_Human3.05353020
13MYC_18555785_ChIP-Seq_MESCs_Mouse3.03534439
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.87895638
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.62154279
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55513687
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43544796
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26132176
19MYCN_18555785_ChIP-Seq_MESCs_Mouse2.25446651
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18868026
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.16942945
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.16942945
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.16942945
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16223884
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13476593
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12235627
27GBX2_23144817_ChIP-Seq_PC3_Human2.09600740
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06743891
29RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03685770
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01824881
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00546161
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99957980
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95331360
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.86071331
35TP53_22573176_ChIP-Seq_HFKS_Human1.82698885
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82629986
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79253165
38TAF15_26573619_Chip-Seq_HEK293_Human1.79201605
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77811985
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77758725
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76668289
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75432737
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74292417
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74219223
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.71669038
46ER_23166858_ChIP-Seq_MCF-7_Human1.70150522
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.70134661
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70037945
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66808790
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.62814329
51IRF1_19129219_ChIP-ChIP_H3396_Human1.60129044
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60075220
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59402894
54P300_19829295_ChIP-Seq_ESCs_Human1.56074427
55BCAT_22108803_ChIP-Seq_LS180_Human1.53775100
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.53708776
57VDR_23849224_ChIP-Seq_CD4+_Human1.52689242
58NANOG_19829295_ChIP-Seq_ESCs_Human1.51716587
59SOX2_19829295_ChIP-Seq_ESCs_Human1.51716587
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51291541
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47193256
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47013430
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45670105
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45085634
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.44116679
66XRN2_22483619_ChIP-Seq_HELA_Human1.43203480
67STAT3_23295773_ChIP-Seq_U87_Human1.42338062
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41871942
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.41864774
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40751153
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39882585
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.39882585
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39151572
74TCF4_23295773_ChIP-Seq_U87_Human1.37853309
75NCOR_22424771_ChIP-Seq_293T_Human1.37820431
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36239208
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35522555
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.35462877
79* RNF2_27304074_Chip-Seq_NSC_Mouse1.35423461
80* RUNX2_22187159_ChIP-Seq_PCA_Human1.35289383
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35191075
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35191075
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33110444
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33103317
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33018143
86KDM5A_27292631_Chip-Seq_BREAST_Human1.29816520
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.29334227
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.28894460
89REST_21632747_ChIP-Seq_MESCs_Mouse1.27521424
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27329588
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27088958
92* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25595758
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25504809
94AR_25329375_ChIP-Seq_VCAP_Human1.24893927
95CBP_20019798_ChIP-Seq_JUKART_Human1.24268894
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24268894
97AR_20517297_ChIP-Seq_VCAP_Human1.22574888
98RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19532127
99NANOG_20526341_ChIP-Seq_ESCs_Human1.19217116
100GABP_19822575_ChIP-Seq_HepG2_Human1.18685728
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18273832
102MYC_19829295_ChIP-Seq_ESCs_Human1.17403599
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17223019
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.16177065
105FOXP3_21729870_ChIP-Seq_TREG_Human1.15692956
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14323723
107DCP1A_22483619_ChIP-Seq_HELA_Human1.13683733
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13618423
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.13197013
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13133804
111TTF2_22483619_ChIP-Seq_HELA_Human1.12519897
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.12326108
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11828087
114ERA_21632823_ChIP-Seq_H3396_Human1.10924953
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10548408
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09684564
117* SMAD4_21799915_ChIP-Seq_A2780_Human1.09166257
118MYC_18940864_ChIP-ChIP_HL60_Human1.08975383
119FOXH1_21741376_ChIP-Seq_EPCs_Human1.08251596
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08196221
121SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07796241
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.05594817
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04871215
124TCF4_22108803_ChIP-Seq_LS180_Human1.04638622
125FLI1_27457419_Chip-Seq_LIVER_Mouse1.04457088
126ELK1_19687146_ChIP-ChIP_HELA_Human1.03399200
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00953021
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00199494
129TAF2_19829295_ChIP-Seq_ESCs_Human0.99219414
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98792052
131OCT4_20526341_ChIP-Seq_ESCs_Human0.98672622
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98507780
133FOXH1_21741376_ChIP-Seq_ESCs_Human0.95551494
134EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94577556
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94047346
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93496976
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93435799
138RAC3_21632823_ChIP-Seq_H3396_Human0.92875367
139FUS_26573619_Chip-Seq_HEK293_Human0.92836243
140THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92218334
141EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92181977
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91345582
143GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90580797
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89243713
145RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89189149
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89177848
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89167552
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88515046
149HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87664707
150SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83978623
151CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83561595
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78378877
153HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77117085
154ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.75224480
155YY1_21170310_ChIP-Seq_MESCs_Mouse0.72466285
156NANOG_21062744_ChIP-ChIP_HESCs_Human0.72176634
157CIITA_25753668_ChIP-Seq_RAJI_Human0.71878599
158EWS_26573619_Chip-Seq_HEK293_Human0.71869960
159ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71326790
160HTT_18923047_ChIP-ChIP_STHdh_Human0.70751744
161RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.69891667
162REST_19997604_ChIP-ChIP_NEURONS_Mouse0.67853555
163HOXB7_26014856_ChIP-Seq_BT474_Human0.65928660
164SMAD_19615063_ChIP-ChIP_OVARY_Human0.65535237
165POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.65228727
166RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64769634
167TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63984215
168SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.63179782
169CDX2_22108803_ChIP-Seq_LS180_Human0.62276690
170NOTCH1_21737748_ChIP-Seq_TLL_Human0.62265109
171DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.61797584
172TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.61750010
173TFEB_21752829_ChIP-Seq_HELA_Human0.60696949
174ETV1_20927104_ChIP-Seq_GIST48_Human0.60254058
175CHD1_26751641_Chip-Seq_LNCaP_Human0.58561366
176TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.56757049
177HNFA_21074721_ChIP-Seq_CACO-2_Human0.56188574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.68517975
2MP0008995_early_reproductive_senescence6.19395071
3MP0010094_abnormal_chromosome_stability4.36242780
4MP0003786_premature_aging4.11905397
5MP0008057_abnormal_DNA_replication4.05684497
6* MP0002210_abnormal_sex_determination3.97467052
7MP0008058_abnormal_DNA_repair3.82653930
8MP0003111_abnormal_nucleus_morphology3.77823186
9MP0003693_abnormal_embryo_hatching3.60523701
10MP0003123_paternal_imprinting3.49477915
11* MP0001929_abnormal_gametogenesis3.36308346
12* MP0001145_abnormal_male_reproductive3.14387286
13MP0003077_abnormal_cell_cycle3.12270604
14MP0004957_abnormal_blastocyst_morpholog2.97925848
15* MP0000653_abnormal_sex_gland2.97653599
16* MP0003698_abnormal_male_reproductive2.43436416
17MP0008007_abnormal_cellular_replicative2.20506534
18MP0005551_abnormal_eye_electrophysiolog2.20146107
19MP0001986_abnormal_taste_sensitivity2.16795599
20MP0003136_yellow_coat_color1.95342032
21MP0003718_maternal_effect1.93948758
22MP0006276_abnormal_autonomic_nervous1.90750993
23MP0003121_genomic_imprinting1.87663321
24MP0001119_abnormal_female_reproductive1.87128403
25MP0001730_embryonic_growth_arrest1.85910485
26MP0010307_abnormal_tumor_latency1.85901391
27MP0008872_abnormal_physiological_respon1.80877328
28MP0003890_abnormal_embryonic-extraembry1.80409320
29MP0004147_increased_porphyrin_level1.80227968
30MP0008932_abnormal_embryonic_tissue1.78998301
31MP0003195_calcinosis1.78887285
32MP0000350_abnormal_cell_proliferation1.77587197
33MP0008875_abnormal_xenobiotic_pharmacok1.72303732
34MP0002837_dystrophic_cardiac_calcinosis1.68172934
35MP0004043_abnormal_pH_regulation1.58647860
36* MP0002161_abnormal_fertility/fecundity1.57658255
37MP0001968_abnormal_touch/_nociception1.55631614
38MP0003787_abnormal_imprinting1.53816103
39MP0002735_abnormal_chemical_nociception1.53379699
40MP0005084_abnormal_gallbladder_morpholo1.50294700
41MP0005167_abnormal_blood-brain_barrier1.49388352
42MP0002938_white_spotting1.47667936
43MP0003699_abnormal_female_reproductive1.44906874
44MP0009745_abnormal_behavioral_response1.40845037
45MP0001919_abnormal_reproductive_system1.40439705
46MP0002876_abnormal_thyroid_physiology1.38159794
47MP0004142_abnormal_muscle_tone1.36827893
48MP0005645_abnormal_hypothalamus_physiol1.36125287
49MP0002272_abnormal_nervous_system1.35915872
50MP0004885_abnormal_endolymph1.30931344
51MP0002928_abnormal_bile_duct1.30877797
52MP0005380_embryogenesis_phenotype1.27805155
53MP0001672_abnormal_embryogenesis/_devel1.27805155
54MP0001697_abnormal_embryo_size1.27478585
55MP0002138_abnormal_hepatobiliary_system1.27208205
56MP0000372_irregular_coat_pigmentation1.26340894
57MP0002085_abnormal_embryonic_tissue1.25594972
58MP0003878_abnormal_ear_physiology1.23311746
59MP0005377_hearing/vestibular/ear_phenot1.23311746
60MP0004145_abnormal_muscle_electrophysio1.23254946
61MP0005076_abnormal_cell_differentiation1.18168914
62MP0001485_abnormal_pinna_reflex1.17953376
63MP0006292_abnormal_olfactory_placode1.16941517
64MP0002572_abnormal_emotion/affect_behav1.16857500
65MP0002084_abnormal_developmental_patter1.16102080
66MP0002067_abnormal_sensory_capabilities1.14736790
67MP0001188_hyperpigmentation1.12718681
68MP0001486_abnormal_startle_reflex1.12627526
69MP0001501_abnormal_sleep_pattern1.12451908
70MP0004742_abnormal_vestibular_system1.12373278
71MP0003806_abnormal_nucleotide_metabolis1.11478688
72MP0002733_abnormal_thermal_nociception1.08512240
73MP0005423_abnormal_somatic_nervous1.07680933
74MP0004197_abnormal_fetal_growth/weight/1.07631668
75MP0003984_embryonic_growth_retardation1.07003262
76MP0002736_abnormal_nociception_after1.06728564
77MP0009046_muscle_twitch1.06213193
78MP0005174_abnormal_tail_pigmentation1.06066011
79MP0002163_abnormal_gland_morphology1.05686540
80MP0010352_gastrointestinal_tract_polyps1.03720475
81MP0003937_abnormal_limbs/digits/tail_de1.02757535
82MP0005253_abnormal_eye_physiology1.02020737
83MP0005647_abnormal_sex_gland1.01809857
84MP0004808_abnormal_hematopoietic_stem1.01735419
85MP0002557_abnormal_social/conspecific_i1.00963565
86MP0002088_abnormal_embryonic_growth/wei1.00867998
87MP0003315_abnormal_perineum_morphology0.99571848
88MP0000778_abnormal_nervous_system0.98831338
89MP0000313_abnormal_cell_death0.98638532
90MP0002063_abnormal_learning/memory/cond0.97621082
91MP0002184_abnormal_innervation0.96283879
92MP0001970_abnormal_pain_threshold0.93938930
93MP0004133_heterotaxia0.93851029
94MP0002139_abnormal_hepatobiliary_system0.93737441
95MP0002638_abnormal_pupillary_reflex0.93269841
96MP0005410_abnormal_fertilization0.93219268
97MP0002080_prenatal_lethality0.92046278
98MP0002653_abnormal_ependyma_morphology0.91342484
99MP0002086_abnormal_extraembryonic_tissu0.90718554
100MP0002160_abnormal_reproductive_system0.90657637
101MP0009672_abnormal_birth_weight0.89148698
102MP0005085_abnormal_gallbladder_physiolo0.89067021
103MP0003011_delayed_dark_adaptation0.88260707
104MP0002019_abnormal_tumor_incidence0.88235105
105MP0004215_abnormal_myocardial_fiber0.88212062
106MP0006035_abnormal_mitochondrial_morpho0.88113643
107MP0002102_abnormal_ear_morphology0.88001868
108MP0002277_abnormal_respiratory_mucosa0.87149353
109MP0003936_abnormal_reproductive_system0.86920045
110MP0000631_abnormal_neuroendocrine_gland0.85476786
111MP0006072_abnormal_retinal_apoptosis0.84977180
112MP0001529_abnormal_vocalization0.84134674
113MP0002095_abnormal_skin_pigmentation0.83960601
114MP0009379_abnormal_foot_pigmentation0.83577651
115MP0003880_abnormal_central_pattern0.82840562
116MP0001440_abnormal_grooming_behavior0.81366764
117MP0003941_abnormal_skin_development0.80293783
118MP0003635_abnormal_synaptic_transmissio0.79826352
119MP0005195_abnormal_posterior_eye0.78239379
120MP0000049_abnormal_middle_ear0.77598473
121MP0005451_abnormal_body_composition0.77484472
122MP0008775_abnormal_heart_ventricle0.77318285
123MP0005395_other_phenotype0.77101369
124MP0002064_seizures0.76071554
125MP0002752_abnormal_somatic_nervous0.75962819
126MP0005379_endocrine/exocrine_gland_phen0.75204069
127MP0004019_abnormal_vitamin_homeostasis0.74677856
128MP0002734_abnormal_mechanical_nocicepti0.72244200
129MP0000955_abnormal_spinal_cord0.71969398
130MP0002009_preneoplasia0.70931991
131MP0005408_hypopigmentation0.69778093
132MP0005621_abnormal_cell_physiology0.69402558
133MP0009703_decreased_birth_body0.67866124
134MP0000427_abnormal_hair_cycle0.65231590
135MP0000579_abnormal_nail_morphology0.65038444
136MP0003119_abnormal_digestive_system0.61293988
137MP0005389_reproductive_system_phenotype0.61077969
138MP0003646_muscle_fatigue0.59843714
139MP0001915_intracranial_hemorrhage0.57835856
140MP0005384_cellular_phenotype0.57436559
141MP0002396_abnormal_hematopoietic_system0.55766963
142MP0000383_abnormal_hair_follicle0.50472872
143MP0004185_abnormal_adipocyte_glucose0.49594385
144MP0000432_abnormal_head_morphology0.49026975
145MP0003861_abnormal_nervous_system0.48100344
146MP0003755_abnormal_palate_morphology0.47203390
147MP0010234_abnormal_vibrissa_follicle0.47153697
148MP0000569_abnormal_digit_pigmentation0.46583944
149MP0001293_anophthalmia0.46130406
150MP0003567_abnormal_fetal_cardiomyocyte0.45825865
151MP0010678_abnormal_skin_adnexa0.45437751
152MP0003221_abnormal_cardiomyocyte_apopto0.44382484
153MP0003566_abnormal_cell_adhesion0.44039597
154MP0002111_abnormal_tail_morphology0.43491522
155MP0000462_abnormal_digestive_system0.42371464
156MP0003115_abnormal_respiratory_system0.41199169
157MP0000428_abnormal_craniofacial_morphol0.40460463
158MP0003705_abnormal_hypodermis_morpholog0.38693941
159MP0001177_atelectasis0.38408933
160MP0000537_abnormal_urethra_morphology0.36726909
161MP0001727_abnormal_embryo_implantation0.35996227
162MP0000566_synostosis0.35929205
163MP0002075_abnormal_coat/hair_pigmentati0.35897437
164MP0001286_abnormal_eye_development0.35226479
165MP0002092_abnormal_eye_morphology0.33400217
166MP0000613_abnormal_salivary_gland0.33181814
167MP0008260_abnormal_autophagy0.30448601
168MP0003935_abnormal_craniofacial_develop0.30125169
169MP0001186_pigmentation_phenotype0.29752912
170MP0003632_abnormal_nervous_system0.29565808
171MP0005623_abnormal_meninges_morphology0.29234441

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)8.42638950
2Abnormal spermatogenesis (HP:0008669)7.45727937
3Type II lissencephaly (HP:0007260)5.58696715
4Chromsome breakage (HP:0040012)5.50345406
5Abnormality of the labia minora (HP:0012880)5.49336023
6Cerebellar dysplasia (HP:0007033)5.43707740
7Chromosomal breakage induced by crosslinking agents (HP:0003221)5.19574802
8Abnormality of the lower motor neuron (HP:0002366)4.78676331
9Facial hemangioma (HP:0000329)4.71977838
10Birth length less than 3rd percentile (HP:0003561)4.43545776
11Breast hypoplasia (HP:0003187)4.30898411
12Hypoplasia of the pons (HP:0012110)4.30556739
13Abnormality of the pons (HP:0007361)4.16760993
14Papillary thyroid carcinoma (HP:0002895)3.91795580
15Abnormality of midbrain morphology (HP:0002418)3.78143166
16Molar tooth sign on MRI (HP:0002419)3.78143166
17Supernumerary spleens (HP:0009799)3.59377464
18Capillary hemangiomas (HP:0005306)3.57929768
19Abnormality of chromosome stability (HP:0003220)3.54434032
20Decreased electroretinogram (ERG) amplitude (HP:0000654)3.53733405
21Lissencephaly (HP:0001339)3.51635914
22Retinal atrophy (HP:0001105)3.50386312
23Abolished electroretinogram (ERG) (HP:0000550)3.50191429
24Retinal dysplasia (HP:0007973)3.47886205
25Gonadotropin excess (HP:0000837)3.45352899
26Male infertility (HP:0003251)3.35425125
27Patellar aplasia (HP:0006443)3.35159973
28Carpal bone hypoplasia (HP:0001498)3.32002603
29Pancreatic cysts (HP:0001737)3.29691615
303-Methylglutaconic aciduria (HP:0003535)3.23751578
31Shawl scrotum (HP:0000049)3.20346873
32Congenital stationary night blindness (HP:0007642)3.19665309
33Impulsivity (HP:0100710)3.17369732
34Aplasia/Hypoplasia affecting the retina (HP:0008061)3.13471487
35Nephronophthisis (HP:0000090)3.09765809
36Shoulder girdle muscle weakness (HP:0003547)3.06807570
37Ankle contracture (HP:0006466)3.06064618
38Aplasia/Hypoplasia of the patella (HP:0006498)3.05281323
39True hermaphroditism (HP:0010459)3.04870157
40Absent radius (HP:0003974)3.03513881
41Spontaneous abortion (HP:0005268)3.02677544
42Aplasia/Hypoplasia of the fovea (HP:0008060)3.01901378
43Hypoplasia of the fovea (HP:0007750)3.01901378
44Oligodactyly (HP:0012165)2.94254045
45Meckel diverticulum (HP:0002245)2.93066729
46Pancreatic fibrosis (HP:0100732)2.92462737
47Amyotrophic lateral sclerosis (HP:0007354)2.90729625
48Oligodactyly (hands) (HP:0001180)2.90625930
49Abnormality of DNA repair (HP:0003254)2.89122782
50Absent forearm bone (HP:0003953)2.88845569
51Aplasia involving forearm bones (HP:0009822)2.88845569
52Ectopic kidney (HP:0000086)2.88818198
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.76530123
54Upper motor neuron abnormality (HP:0002127)2.76324478
55Abnormality of the preputium (HP:0100587)2.75107770
56Abnormality of chromosome segregation (HP:0002916)2.74355484
57Attenuation of retinal blood vessels (HP:0007843)2.74074746
58Concave nail (HP:0001598)2.72881983
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.70971711
60Ependymoma (HP:0002888)2.70645851
61Abnormality of the ileum (HP:0001549)2.70582408
62Abnormality of the fovea (HP:0000493)2.65825047
6311 pairs of ribs (HP:0000878)2.61636112
64Bilateral microphthalmos (HP:0007633)2.60294918
65Severe muscular hypotonia (HP:0006829)2.59878031
66Sandal gap (HP:0001852)2.56637611
67Rhabdomyosarcoma (HP:0002859)2.55597233
68Abnormality of the renal medulla (HP:0100957)2.53951585
69Short tibia (HP:0005736)2.51956784
70Abnormality of alanine metabolism (HP:0010916)2.50377466
71Hyperalaninemia (HP:0003348)2.50377466
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50377466
73Wrist flexion contracture (HP:0001239)2.47848078
74Medial flaring of the eyebrow (HP:0010747)2.44102896
75Duodenal stenosis (HP:0100867)2.43686597
76Small intestinal stenosis (HP:0012848)2.43686597
77Absent thumb (HP:0009777)2.43544653
78Selective tooth agenesis (HP:0001592)2.41965187
79Thyroid carcinoma (HP:0002890)2.41869076
80Medulloblastoma (HP:0002885)2.41843192
81Tubular atrophy (HP:0000092)2.40246936
82Colon cancer (HP:0003003)2.40180065
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37601062
84Duplicated collecting system (HP:0000081)2.35877813
85Short thumb (HP:0009778)2.35808057
86Abnormal rod and cone electroretinograms (HP:0008323)2.33027896
87Pachygyria (HP:0001302)2.29728564
88Cystic liver disease (HP:0006706)2.28937519
89Hyperglycinuria (HP:0003108)2.28053902
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26632994
91Chronic hepatic failure (HP:0100626)2.25134236
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.24610024
93Progressive external ophthalmoplegia (HP:0000590)2.22966390
94Astrocytoma (HP:0009592)2.21716594
95Abnormality of the astrocytes (HP:0100707)2.21716594
96Horseshoe kidney (HP:0000085)2.21678830
97Intellectual disability, profound (HP:0002187)2.21461821
98Pelvic girdle muscle weakness (HP:0003749)2.19611587
99Progressive inability to walk (HP:0002505)2.18785618
100Nephroblastoma (Wilms tumor) (HP:0002667)2.17133639
101Cafe-au-lait spot (HP:0000957)2.13861256
102Aplasia/Hypoplasia of the earlobes (HP:0009906)2.13839269
103Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.12471944
104Atrophy/Degeneration involving motor neurons (HP:0007373)2.12279563
105Abnormality of the renal collecting system (HP:0004742)2.11047874
106Abnormal lung lobation (HP:0002101)2.10914125
107Neoplasm of the oral cavity (HP:0100649)2.08743003
108Biliary tract neoplasm (HP:0100574)2.07291608
109Dynein arm defect of respiratory motile cilia (HP:0012255)2.07091917
110Absent/shortened dynein arms (HP:0200106)2.07091917
111Inability to walk (HP:0002540)2.07055376
112Hyperventilation (HP:0002883)2.06897688
113Scotoma (HP:0000575)2.05554849
114Decreased circulating renin level (HP:0003351)2.05110210
115Abnormality of the renal cortex (HP:0011035)2.04897489
116Glioma (HP:0009733)2.04541647
117Nephrogenic diabetes insipidus (HP:0009806)2.04039109
118Bile duct proliferation (HP:0001408)2.01016313
119Abnormal biliary tract physiology (HP:0012439)2.01016313
120Polydipsia (HP:0001959)2.00810032
121Abnormal drinking behavior (HP:0030082)2.00810032
122Volvulus (HP:0002580)1.99058520
123Metaphyseal cupping (HP:0003021)1.97185159
124CNS hypomyelination (HP:0003429)1.96117313
125Abnormality of the phalanges of the hallux (HP:0010057)1.96051091
126Unilateral renal agenesis (HP:0000122)1.95986679
127Non-midline cleft lip (HP:0100335)1.95875086
128Abnormality of the carotid arteries (HP:0005344)1.95800326
129Embryonal renal neoplasm (HP:0011794)1.95649991
130Hand muscle atrophy (HP:0009130)1.95206762
131Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95135234
132Decreased subcutaneous fat (HP:0001002)1.94948718
133Male pseudohermaphroditism (HP:0000037)1.93420553
134Cystic hygroma (HP:0000476)1.92337880
135Anencephaly (HP:0002323)1.92166661
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.90753953
137Clubbing of toes (HP:0100760)1.90233625
138Sclerocornea (HP:0000647)1.88605840
139Abnormality of serine family amino acid metabolism (HP:0010894)1.88599973
140Abnormality of glycine metabolism (HP:0010895)1.88599973
141Abnormality of the duodenum (HP:0002246)1.88572438
142Premature ovarian failure (HP:0008209)1.87430531
143Sloping forehead (HP:0000340)1.86751604
144Abnormal biliary tract morphology (HP:0012440)1.86722970
145Neoplasm of striated muscle (HP:0009728)1.86412012
146Myelodysplasia (HP:0002863)1.85343297
147Sex reversal (HP:0012245)1.84872464
148Abnormal sex determination (HP:0012244)1.84872464
149Long eyelashes (HP:0000527)1.84464498
150Secondary amenorrhea (HP:0000869)1.84063198
151Breast aplasia (HP:0100783)1.83320541
152Aplasia/Hypoplasia of the ulna (HP:0006495)1.82678692
153Heterotopia (HP:0002282)1.82249314
154Abnormality of lateral ventricle (HP:0030047)1.81945552
155Hypoplasia of the brainstem (HP:0002365)1.81621730
156Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81621730
157Fibular hypoplasia (HP:0003038)1.81579684
158Agnosia (HP:0010524)1.80946723
159Congenital hepatic fibrosis (HP:0002612)1.80061361
160Abnormality of the fingertips (HP:0001211)1.79212030
161Aplasia/Hypoplasia of the breasts (HP:0010311)1.78408382
162Aplasia/Hypoplasia of the spleen (HP:0010451)1.77810642
163Neoplasm of the pancreas (HP:0002894)1.77439860
164Abnormality of the musculature of the pelvis (HP:0001469)1.77380243
165Abnormality of the hip-girdle musculature (HP:0001445)1.77380243
166Abnormality of the anterior horn cell (HP:0006802)1.77161272
167Bony spicule pigmentary retinopathy (HP:0007737)1.76352357
168Dandy-Walker malformation (HP:0001305)1.73617658
169Conjugated hyperbilirubinemia (HP:0002908)1.73161887
170Postaxial foot polydactyly (HP:0001830)1.71444785
171Tachypnea (HP:0002789)1.70274530
172Gait imbalance (HP:0002141)1.69898240
173Oligohydramnios (HP:0001562)1.68008458
174Pendular nystagmus (HP:0012043)1.67729973
175Gaze-evoked nystagmus (HP:0000640)1.66565205
176Asplenia (HP:0001746)1.66359324
177Brushfield spots (HP:0001088)1.64834441
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.64488966
179Tubulointerstitial nephritis (HP:0001970)1.63345513
180Preaxial hand polydactyly (HP:0001177)1.61530147
181Decreased central vision (HP:0007663)1.60123113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.51595231
2ACVR1B4.67482433
3CDK123.79728719
4WEE13.50879398
5STK38L3.32972575
6PNCK3.11465202
7NEK22.99004641
8ADRBK22.95044969
9PLK42.91413912
10FRK2.90463344
11BRSK22.83466728
12TLK12.68526978
13WNK42.66322946
14TTK2.59564150
15CDK192.46191937
16PLK12.45253696
17NEK12.23146628
18NUAK12.06467249
19LATS22.04504441
20LATS12.03620798
21BUB11.97666145
22TXK1.94820748
23STK161.91399870
24OXSR11.91011943
25IRAK31.87429408
26TAF11.87059001
27GRK11.86963761
28MKNK21.80250244
29PBK1.79433541
30CHEK21.70082038
31STK391.68837522
32CHEK11.67544583
33NTRK31.65746817
34MAP4K21.65442687
35STK31.60194282
36CASK1.59175419
37PLK31.58116784
38BRSK11.57777888
39CDK71.53095881
40STK111.52777197
41BRD41.52431716
42ATR1.51993715
43MELK1.49992513
44TRIM281.49243775
45SRPK11.48202674
46MAPK131.47197876
47PTK2B1.43290092
48MAP3K61.42694125
49PDK41.39813257
50PDK31.39813257
51DAPK21.39239371
52STK241.35379270
53TAOK31.31642640
54ATM1.31062680
55AURKB1.30370066
56CDK91.24396299
57EIF2AK11.18873749
58TIE11.18178535
59INSRR1.16029114
60MKNK11.15546651
61CDK81.15440829
62STK41.14486268
63RIPK41.14450059
64DYRK31.07658392
65MAPK151.06460189
66SIK21.04769979
67MAP3K41.01789055
68ERBB41.01477573
69PRKCG0.99131559
70KSR20.97903150
71CDK40.97559394
72CDK20.95964928
73TSSK60.95466846
74BMPR20.94319433
75MAP2K70.92635443
76WNK30.91678317
77TYRO30.90524077
78EPHA40.89245567
79CDK10.88504625
80MAP3K90.84394933
81AURKA0.75385859
82PIM10.72443162
83ADRBK10.71595436
84ERBB20.69817845
85PDK20.67792290
86PHKG10.67109218
87PHKG20.67109218
88PLK20.67098817
89EEF2K0.66900691
90VRK10.63431337
91EIF2AK30.62923776
92RPS6KB20.62812899
93BMPR1B0.61314245
94CCNB10.61183557
95WNK10.61073744
96KSR10.60899368
97CDK30.60254872
98MARK10.59670915
99SCYL20.58026145
100PRKCI0.57526156
101PRKCE0.57413587
102MAP3K110.56650287
103CDC42BPA0.56645398
104CAMK10.56601323
105MAP3K70.55526321
106PRKCZ0.55060178
107BRAF0.54833571
108PRKD30.53884893
109STK380.53705065
110ZAK0.53424399
111MAP3K80.52140886
112RPS6KA40.51810502
113CLK10.51606595
114TGFBR10.50706979
115PIK3CA0.49443516
116PINK10.48889881
117BCR0.48592326
118MAPKAPK30.47735687
119MAP3K20.47262883
120PIK3CG0.46158196
121MARK30.43399920
122CSF1R0.43131488
123GSK3B0.42840221
124PRKDC0.42727045
125CSNK1D0.42705561
126NTRK20.42564639
127MET0.42361475
128PASK0.40730575
129CDK60.40087774
130PKN10.39617957
131CAMK2A0.38564927
132PAK30.37725460
133IRAK40.37104723
134MTOR0.37095305
135RAF10.36363437
136CSNK1E0.36285772
137DYRK1A0.35363524
138MAPK140.35098020
139MAP2K20.33778271
140EPHA20.33417495
141CSNK2A20.33346019
142RPS6KA60.33118533
143STK100.31208527
144IRAK10.31129908
145BCKDK0.30857013
146IGF1R0.30706989
147DYRK20.30276216
148CSNK1G10.30154795
149SGK10.29720594
150PRKCA0.29600547
151CSNK2A10.29466565
152ALK0.29133526
153PRKACA0.28318798
154MAPK100.27689787
155CAMK40.27264448
156MAPK110.27097030
157PRKAA10.25808622
158CSNK1G20.25529649
159MAPK80.23297501
160MUSK0.22757559
161AKT10.22564441
162LIMK10.20889822

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.48182679
2Basal transcription factors_Homo sapiens_hsa030224.58875390
3Homologous recombination_Homo sapiens_hsa034403.95674232
4Cell cycle_Homo sapiens_hsa041103.78685627
5DNA replication_Homo sapiens_hsa030303.74961220
6Mismatch repair_Homo sapiens_hsa034303.73703640
7RNA transport_Homo sapiens_hsa030133.63210031
8RNA polymerase_Homo sapiens_hsa030203.45627198
9Fanconi anemia pathway_Homo sapiens_hsa034603.16151297
10mRNA surveillance pathway_Homo sapiens_hsa030152.93247465
11Spliceosome_Homo sapiens_hsa030402.66473255
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.65027920
13Nucleotide excision repair_Homo sapiens_hsa034202.59073414
14Phototransduction_Homo sapiens_hsa047442.57323094
15RNA degradation_Homo sapiens_hsa030182.55400840
16Non-homologous end-joining_Homo sapiens_hsa034502.47034897
17Olfactory transduction_Homo sapiens_hsa047402.28400525
18Butanoate metabolism_Homo sapiens_hsa006502.15558138
19Nitrogen metabolism_Homo sapiens_hsa009102.10056707
20Oocyte meiosis_Homo sapiens_hsa041142.07259585
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05435272
22Nicotine addiction_Homo sapiens_hsa050332.04460165
23Base excision repair_Homo sapiens_hsa034102.02157914
24One carbon pool by folate_Homo sapiens_hsa006702.01313177
25Regulation of autophagy_Homo sapiens_hsa041401.99761904
26p53 signaling pathway_Homo sapiens_hsa041151.88118374
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86831371
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.81781939
29Propanoate metabolism_Homo sapiens_hsa006401.80595381
30Pyrimidine metabolism_Homo sapiens_hsa002401.80049875
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74560013
32Oxidative phosphorylation_Homo sapiens_hsa001901.66523643
33Tryptophan metabolism_Homo sapiens_hsa003801.64582123
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58403195
35Caffeine metabolism_Homo sapiens_hsa002321.54389909
36Sulfur relay system_Homo sapiens_hsa041221.53403390
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53168360
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.48164468
39Vitamin B6 metabolism_Homo sapiens_hsa007501.42499145
40Parkinsons disease_Homo sapiens_hsa050121.40022062
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39994919
42ABC transporters_Homo sapiens_hsa020101.38915169
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.37397463
44Histidine metabolism_Homo sapiens_hsa003401.37212948
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36077257
46Proteasome_Homo sapiens_hsa030501.34593492
47Retinol metabolism_Homo sapiens_hsa008301.34238946
48Purine metabolism_Homo sapiens_hsa002301.32370066
49Herpes simplex infection_Homo sapiens_hsa051681.29201708
50Fatty acid elongation_Homo sapiens_hsa000621.29079799
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28697601
52Dorso-ventral axis formation_Homo sapiens_hsa043201.28514883
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28329306
54Peroxisome_Homo sapiens_hsa041461.27577779
55Fat digestion and absorption_Homo sapiens_hsa049751.27557434
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27411651
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26700565
58TGF-beta signaling pathway_Homo sapiens_hsa043501.21938765
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.19812373
60beta-Alanine metabolism_Homo sapiens_hsa004101.19608638
61Selenocompound metabolism_Homo sapiens_hsa004501.16252137
62Epstein-Barr virus infection_Homo sapiens_hsa051691.09867985
63Morphine addiction_Homo sapiens_hsa050321.07319979
64SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02576045
65Chemical carcinogenesis_Homo sapiens_hsa052041.00643665
66Cardiac muscle contraction_Homo sapiens_hsa042600.99810198
67Thyroid cancer_Homo sapiens_hsa052160.92759842
68Taste transduction_Homo sapiens_hsa047420.92137070
69Pentose phosphate pathway_Homo sapiens_hsa000300.91349115
70Protein export_Homo sapiens_hsa030600.91296260
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91289995
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.90455365
73Arachidonic acid metabolism_Homo sapiens_hsa005900.89733281
74Lysine degradation_Homo sapiens_hsa003100.87435861
75Insulin secretion_Homo sapiens_hsa049110.84921615
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84329020
77MicroRNAs in cancer_Homo sapiens_hsa052060.81227821
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80254742
79Ribosome_Homo sapiens_hsa030100.80014933
80HTLV-I infection_Homo sapiens_hsa051660.78692551
81Viral carcinogenesis_Homo sapiens_hsa052030.78077050
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77326934
83Serotonergic synapse_Homo sapiens_hsa047260.76649178
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74973572
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74305908
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72203116
87Glutamatergic synapse_Homo sapiens_hsa047240.70412462
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69481441
89Influenza A_Homo sapiens_hsa051640.68739458
90GABAergic synapse_Homo sapiens_hsa047270.67441875
91Alzheimers disease_Homo sapiens_hsa050100.65750179
92Hippo signaling pathway_Homo sapiens_hsa043900.65640643
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65136540
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.62803988
95Biosynthesis of amino acids_Homo sapiens_hsa012300.60210771
96Circadian rhythm_Homo sapiens_hsa047100.58996374
97Metabolic pathways_Homo sapiens_hsa011000.58365454
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57784436
99Small cell lung cancer_Homo sapiens_hsa052220.57485635
100Adherens junction_Homo sapiens_hsa045200.57069203
101Steroid biosynthesis_Homo sapiens_hsa001000.56455669
102Fatty acid degradation_Homo sapiens_hsa000710.55367922
103Calcium signaling pathway_Homo sapiens_hsa040200.54516686
104Primary immunodeficiency_Homo sapiens_hsa053400.53969791
105Pancreatic cancer_Homo sapiens_hsa052120.53839164
106Circadian entrainment_Homo sapiens_hsa047130.53802666
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.52681117
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50751758
109Colorectal cancer_Homo sapiens_hsa052100.48120491
110Asthma_Homo sapiens_hsa053100.47036790
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46739517
112Notch signaling pathway_Homo sapiens_hsa043300.45974017
113FoxO signaling pathway_Homo sapiens_hsa040680.45228364
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43881312
115Pancreatic secretion_Homo sapiens_hsa049720.43716462
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43403196
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41266635
118Fatty acid metabolism_Homo sapiens_hsa012120.41190593
119Collecting duct acid secretion_Homo sapiens_hsa049660.40777039
120Salivary secretion_Homo sapiens_hsa049700.40329930
121Glutathione metabolism_Homo sapiens_hsa004800.39898402
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39503306
123Long-term depression_Homo sapiens_hsa047300.38257933
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37499042
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36521842
126Tight junction_Homo sapiens_hsa045300.35831339
127Linoleic acid metabolism_Homo sapiens_hsa005910.35596478
128Ether lipid metabolism_Homo sapiens_hsa005650.34681132
129Systemic lupus erythematosus_Homo sapiens_hsa053220.33027677
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31309948
131Renal cell carcinoma_Homo sapiens_hsa052110.30692360
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28694404
133Pathways in cancer_Homo sapiens_hsa052000.27170690
134Huntingtons disease_Homo sapiens_hsa050160.26486695
135Prostate cancer_Homo sapiens_hsa052150.25324592
136Glycerolipid metabolism_Homo sapiens_hsa005610.21731962
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.20473578
138Folate biosynthesis_Homo sapiens_hsa007900.19014970
139Ovarian steroidogenesis_Homo sapiens_hsa049130.18831975
140Vitamin digestion and absorption_Homo sapiens_hsa049770.18631700
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17396596
142Antigen processing and presentation_Homo sapiens_hsa046120.16746749
143Wnt signaling pathway_Homo sapiens_hsa043100.16114480
144Choline metabolism in cancer_Homo sapiens_hsa052310.12093393
145Basal cell carcinoma_Homo sapiens_hsa052170.11312567
146Hepatitis B_Homo sapiens_hsa051610.08896137
147mTOR signaling pathway_Homo sapiens_hsa041500.08551866
148Mineral absorption_Homo sapiens_hsa049780.08037543
149Alcoholism_Homo sapiens_hsa050340.07003577
150Hedgehog signaling pathway_Homo sapiens_hsa043400.06852567
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06253977
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05304843
153Arginine and proline metabolism_Homo sapiens_hsa003300.03395073
154ECM-receptor interaction_Homo sapiens_hsa045120.03371266
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02401731
156Bladder cancer_Homo sapiens_hsa052190.01623065
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01140393
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01024864
159Non-small cell lung cancer_Homo sapiens_hsa052230.00798988
160Shigellosis_Homo sapiens_hsa05131-0.0484640
161Melanoma_Homo sapiens_hsa05218-0.0466932
162Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0379920
163Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0360625
164Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0348072
165VEGF signaling pathway_Homo sapiens_hsa04370-0.0331973
166NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0209964
167Endometrial cancer_Homo sapiens_hsa05213-0.0157302
168Prolactin signaling pathway_Homo sapiens_hsa04917-0.0139760
169Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0134429
170Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0081018
171Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0043971

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