ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	6.50771818
2	bile acid biosynthetic process (GO:0006699)	5.82605708
3	arginine metabolic process (GO:0006525)	5.44870046
4	serine family amino acid catabolic process (GO:0009071)	5.28400021
5	regulation of triglyceride catabolic process (GO:0010896)	5.23359115
6	phenylpropanoid metabolic process (GO:0009698)	5.08521605
7	drug catabolic process (GO:0042737)	4.91196059
8	cellular glucuronidation (GO:0052695)	4.89390608
9	bile acid metabolic process (GO:0008206)	4.86755326
10	regulation of protein activation cascade (GO:2000257)	4.82329364
11	drug metabolic process (GO:0017144)	4.81402722
12	blood coagulation, intrinsic pathway (GO:0007597)	4.78155780
13	uronic acid metabolic process (GO:0006063)	4.67186621
14	glucuronate metabolic process (GO:0019585)	4.67186621
15	epoxygenase P450 pathway (GO:0019373)	4.61698867
16	male meiosis (GO:0007140)	4.61149061
17	regulation of bile acid biosynthetic process (GO:0070857)	4.59044057
18	cellular ketone body metabolic process (GO:0046950)	4.56925878
19	glycine metabolic process (GO:0006544)	4.49067128
20	acrosome reaction (GO:0007340)	4.45988117
21	negative regulation of sterol transport (GO:0032372)	4.32247811
22	negative regulation of cholesterol transport (GO:0032375)	4.32247811
23	negative regulation of complement activation (GO:0045916)	4.31834441
24	oxidative demethylation (GO:0070989)	4.31305367
25	urea metabolic process (GO:0019627)	4.23580160
26	regulation of fibrinolysis (GO:0051917)	4.22209247
27	steroid catabolic process (GO:0006706)	4.21718967
28	behavioral response to nicotine (GO:0035095)	4.18164486
29	alkaloid metabolic process (GO:0009820)	4.15644281
30	L-phenylalanine catabolic process (GO:0006559)	4.12175225
31	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.12175225
32	heme transport (GO:0015886)	4.12052814
33	regulation of complement activation (GO:0030449)	4.09358770
34	sterol catabolic process (GO:0016127)	4.07301930
35	cholesterol catabolic process (GO:0006707)	4.07301930
36	cysteine metabolic process (GO:0006534)	4.07251468
37	aromatic amino acid family catabolic process (GO:0009074)	4.06997000
38	binding of sperm to zona pellucida (GO:0007339)	4.05642396
39	ketone body metabolic process (GO:1902224)	4.05593736
40	amino-acid betaine metabolic process (GO:0006577)	4.04874268
41	androgen biosynthetic process (GO:0006702)	4.02878903
42	tryptophan catabolic process (GO:0006569)	4.02394133
43	indole-containing compound catabolic process (GO:0042436)	4.02394133
44	indolalkylamine catabolic process (GO:0046218)	4.02394133
45	serine family amino acid metabolic process (GO:0009069)	3.98807321
46	negative regulation of protein activation cascade (GO:2000258)	3.97223778
47	positive regulation of prostaglandin secretion (GO:0032308)	3.94813657
48	glutamine family amino acid catabolic process (GO:0009065)	3.92968732
49	nitrogen cycle metabolic process (GO:0071941)	3.92336675
50	multicellular organism reproduction (GO:0032504)	3.89716981
51	urea cycle (GO:0000050)	3.86706422
52	xenobiotic catabolic process (GO:0042178)	3.85659395
53	regulation of glucocorticoid secretion (GO:2000849)	3.83074621
54	organic cation transport (GO:0015695)	3.65408075
55	acylglycerol homeostasis (GO:0055090)	3.64531590
56	triglyceride homeostasis (GO:0070328)	3.64531590
57	flavonoid metabolic process (GO:0009812)	3.64374206
58	omega-hydroxylase P450 pathway (GO:0097267)	3.63538811
59	arginine catabolic process (GO:0006527)	3.61901904
60	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.61837352
61	hormone catabolic process (GO:0042447)	3.61121159
62	L-phenylalanine metabolic process (GO:0006558)	3.60708978
63	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.60708978
64	complement activation, alternative pathway (GO:0006957)	3.57020826
65	sulfur amino acid catabolic process (GO:0000098)	3.56449284
66	sperm-egg recognition (GO:0035036)	3.56082621
67	sperm motility (GO:0030317)	3.54016270
68	exogenous drug catabolic process (GO:0042738)	3.51702816
69	negative regulation of fibrinolysis (GO:0051918)	3.51560838
70	positive regulation of fatty acid transport (GO:2000193)	3.50156682
71	positive regulation of catecholamine secretion (GO:0033605)	3.47884069
72	alpha-amino acid catabolic process (GO:1901606)	3.42534425
73	carnitine metabolic process (GO:0009437)	3.41916484
74	aspartate family amino acid catabolic process (GO:0009068)	3.38030554
75	L-methionine biosynthetic process (GO:0071265)	3.33407360
76	amino acid salvage (GO:0043102)	3.33407360
77	L-methionine salvage (GO:0071267)	3.33407360
78	tryptophan metabolic process (GO:0006568)	3.32928828
79	peptidyl-glutamic acid carboxylation (GO:0017187)	3.32397931
80	protein carboxylation (GO:0018214)	3.32397931
81	cofactor catabolic process (GO:0051187)	3.32301049
82	positive regulation of glycolytic process (GO:0045821)	3.27879420
83	fusion of sperm to egg plasma membrane (GO:0007342)	3.26652274
84	positive regulation of icosanoid secretion (GO:0032305)	3.25043331
85	fibrinolysis (GO:0042730)	3.23412652
86	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.22823011
87	S-adenosylmethionine metabolic process (GO:0046500)	3.19934929
88	synapsis (GO:0007129)	3.19403550
89	negative regulation of humoral immune response (GO:0002921)	3.18532433
90	bile acid and bile salt transport (GO:0015721)	3.16815568
91	single fertilization (GO:0007338)	3.13677433
92	coenzyme catabolic process (GO:0009109)	3.13049117
93	cellular response to sterol (GO:0036315)	3.12908272
94	indolalkylamine metabolic process (GO:0006586)	3.11236813
95	cellular response to cholesterol (GO:0071397)	3.10621700
96	xenobiotic metabolic process (GO:0006805)	3.08737195
97	regulation of prostaglandin secretion (GO:0032306)	3.08645204
98	aromatic amino acid family metabolic process (GO:0009072)	3.05198973
99	regulation of oxidative stress-induced neuron death (GO:1903203)	3.04753980
100	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.04749603

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.01462209
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.58694703
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.92734898
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.86208292
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.27970882
6	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.27206866
7	GBX2_23144817_ChIP-Seq_PC3_Human	3.10964415
8	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.43691968
9	ER_23166858_ChIP-Seq_MCF-7_Human	2.32627161
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.31036322
11	VDR_22108803_ChIP-Seq_LS180_Human	2.01531277
12	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.01335882
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98108652
14	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.96148481
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.95956476
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.91066132
17	BCAT_22108803_ChIP-Seq_LS180_Human	1.86212415
18	FUS_26573619_Chip-Seq_HEK293_Human	1.83974865
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.76519525
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75443197
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71050016
22	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.68734183
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67132042
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66560950
25	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.64771710
26	P300_19829295_ChIP-Seq_ESCs_Human	1.61556185
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.61055765
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.61055765
29	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.59017530
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.54054890
31	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.53935288
32	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.53737432
33	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.49860299
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49348233
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.48840966
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.48840966
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45212073
38	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.44517027
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.42739800
40	EZH2_22144423_ChIP-Seq_EOC_Human	1.41834550
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.39099667
42	PHF8_20622853_ChIP-Seq_HELA_Human	1.36393689
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35957681
44	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.34801051
45	OCT4_20526341_ChIP-Seq_ESCs_Human	1.34439794
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32521348
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32356681
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.31844535
49	AR_20517297_ChIP-Seq_VCAP_Human	1.31297605
50	NCOR_22424771_ChIP-Seq_293T_Human	1.30527296
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28922437
52	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28311103
53	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27998402
54	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27692981
55	AR_25329375_ChIP-Seq_VCAP_Human	1.27428488
56	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.26995238
57	RBPJ_21746931_ChIP-Seq_IB4_Human	1.26844372
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.25635716
59	ETV1_20927104_ChIP-Seq_GIST48_Human	1.25467347
60	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.24618721
61	ERA_21632823_ChIP-Seq_H3396_Human	1.24522192
62	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.24148990
63	CDX2_22108803_ChIP-Seq_LS180_Human	1.23083599
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22910880
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22910880
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22365655
67	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.21719875
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21456702
69	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.18979729
70	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.16359599
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16325854
72	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.16220676
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15820172
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15381259
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14134579
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.13192685
77	TP53_18474530_ChIP-ChIP_U2OS_Human	1.12054286
78	TBL1_22424771_ChIP-Seq_293T_Human	1.11987677
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11432591
80	GATA1_22025678_ChIP-Seq_K562_Human	1.11407007
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10497100
82	STAT3_23295773_ChIP-Seq_U87_Human	1.10283120
83	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.09812172
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09516042
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09358588
86	RAC3_21632823_ChIP-Seq_H3396_Human	1.08167589
87	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.07899738
88	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07400590
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06873805
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04619494
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03754300
92	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.03623662
93	TP53_22573176_ChIP-Seq_HFKS_Human	1.03115337
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02650784
95	NFYA_21822215_ChIP-Seq_K562_Human	1.01571693
96	ERG_20517297_ChIP-Seq_VCAP_Human	1.01449212
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01193200
98	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00985753
99	STAT1_20625510_ChIP-Seq_HELA_Human	1.00863902
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00813235

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.51553322
2	MP0002138_abnormal_hepatobiliary_system	5.21722652
3	MP0005085_abnormal_gallbladder_physiolo	5.13023931
4	MP0009697_abnormal_copulation	4.75073184
5	MP0003868_abnormal_feces_composition	4.52215064
6	MP0005365_abnormal_bile_salt	4.29393565
7	MP0003195_calcinosis	4.03078421
8	MP0002139_abnormal_hepatobiliary_system	3.72498280
9	MP0008875_abnormal_xenobiotic_pharmacok	3.63474223
10	MP0005410_abnormal_fertilization	3.56977877
11	MP0002102_abnormal_ear_morphology	2.99282482
12	MP0010386_abnormal_urinary_bladder	2.86518091
13	MP0002876_abnormal_thyroid_physiology	2.66212648
14	MP0001666_abnormal_nutrient_absorption	2.58934045
15	MP0003252_abnormal_bile_duct	2.45776099
16	MP0003806_abnormal_nucleotide_metabolis	2.25091723
17	MP0004019_abnormal_vitamin_homeostasis	2.02187659
18	MP0003315_abnormal_perineum_morphology	1.98461338
19	MP0005187_abnormal_penis_morphology	1.93523253
20	MP0001764_abnormal_homeostasis	1.80479366
21	MP0001968_abnormal_touch/_nociception	1.76777885
22	MP0008004_abnormal_stomach_pH	1.63888297
23	MP0002638_abnormal_pupillary_reflex	1.63502303
24	MP0010329_abnormal_lipoprotein_level	1.62414442
25	MP0002090_abnormal_vision	1.60154510
26	MP0005332_abnormal_amino_acid	1.56831913
27	MP0009840_abnormal_foam_cell	1.53503375
28	MP0002160_abnormal_reproductive_system	1.41627494
29	MP0005646_abnormal_pituitary_gland	1.35354750
30	MP0006072_abnormal_retinal_apoptosis	1.26180823
31	MP0003186_abnormal_redox_activity	1.24728259
32	MP0005551_abnormal_eye_electrophysiolog	1.24687313
33	MP0003698_abnormal_male_reproductive	1.24619141
34	MP0003136_yellow_coat_color	1.17834858
35	MP0005395_other_phenotype	1.17759035
36	MP0000538_abnormal_urinary_bladder	1.13915346
37	MP0002837_dystrophic_cardiac_calcinosis	1.12218145
38	MP0001929_abnormal_gametogenesis	1.11731663
39	MP0003718_maternal_effect	1.07798473
40	MP0001905_abnormal_dopamine_level	1.07322332
41	MP0005167_abnormal_blood-brain_barrier	1.05371911
42	MP0002118_abnormal_lipid_homeostasis	1.04286383
43	MP0002909_abnormal_adrenal_gland	1.03893223
44	MP0000569_abnormal_digit_pigmentation	1.03407834
45	MP0008872_abnormal_physiological_respon	1.03315116
46	MP0001501_abnormal_sleep_pattern	1.01530632
47	MP0003638_abnormal_response/metabolism_	0.99434292
48	MP0003879_abnormal_hair_cell	0.97379740
49	MP0009745_abnormal_behavioral_response	0.91774433
50	MP0005647_abnormal_sex_gland	0.87772043
51	MP0010368_abnormal_lymphatic_system	0.87607451
52	MP0008877_abnormal_DNA_methylation	0.86563403
53	MP0002168_other_aberrant_phenotype	0.85723158
54	MP0001984_abnormal_olfaction	0.85383853
55	MP0009643_abnormal_urine_homeostasis	0.85253177
56	MP0005058_abnormal_lysosome_morphology	0.84935536
57	MP0000427_abnormal_hair_cycle	0.82255020
58	MP0005253_abnormal_eye_physiology	0.81999675
59	MP0003045_fibrosis	0.81809539
60	MP0002132_abnormal_respiratory_system	0.80255822
61	MP0002938_white_spotting	0.79027923
62	MP0002254_reproductive_system_inflammat	0.77478788
63	MP0005389_reproductive_system_phenotype	0.76738151
64	MP0006036_abnormal_mitochondrial_physio	0.72198414
65	MP0003011_delayed_dark_adaptation	0.70529887
66	MP0000371_diluted_coat_color	0.67861996
67	MP0000230_abnormal_systemic_arterial	0.65169069
68	MP0001664_abnormal_digestion	0.63243217
69	MP0008995_early_reproductive_senescence	0.59583284
70	MP0001986_abnormal_taste_sensitivity	0.59322283
71	MP0009764_decreased_sensitivity_to	0.58961961
72	MP0005083_abnormal_biliary_tract	0.58590098
73	MP0000653_abnormal_sex_gland	0.57936700
74	MP0000609_abnormal_liver_physiology	0.56407169
75	MP0000343_altered_response_to	0.55731165
76	MP0002736_abnormal_nociception_after	0.54762818
77	MP0005367_renal/urinary_system_phenotyp	0.54406536
78	MP0000516_abnormal_urinary_system	0.54406536
79	MP0005319_abnormal_enzyme/_coenzyme	0.53703332
80	MP0009642_abnormal_blood_homeostasis	0.53307383
81	MP0002161_abnormal_fertility/fecundity	0.52088841
82	MP0005174_abnormal_tail_pigmentation	0.50849292
83	MP0005636_abnormal_mineral_homeostasis	0.50382455
84	MP0004043_abnormal_pH_regulation	0.50191725
85	MP0001145_abnormal_male_reproductive	0.50130377
86	MP0000604_amyloidosis	0.49386956
87	MP0005376_homeostasis/metabolism_phenot	0.49362714
88	MP0001502_abnormal_circadian_rhythm	0.49031482
89	MP0001485_abnormal_pinna_reflex	0.48982355
90	MP0004885_abnormal_endolymph	0.47670111
91	MP0005220_abnormal_exocrine_pancreas	0.47635921
92	MP0000372_irregular_coat_pigmentation	0.46466751
93	MP0002210_abnormal_sex_determination	0.46376428
94	MP0005171_absent_coat_pigmentation	0.44694602
95	MP0002572_abnormal_emotion/affect_behav	0.43026851
96	MP0005448_abnormal_energy_balance	0.42889009
97	MP0000383_abnormal_hair_follicle	0.42868498
98	MP0002272_abnormal_nervous_system	0.41901783
99	MP0003953_abnormal_hormone_level	0.41519958
100	MP0002078_abnormal_glucose_homeostasis	0.41435939

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	7.73774333
2	Deep venous thrombosis (HP:0002625)	6.53627632
3	Prolonged partial thromboplastin time (HP:0003645)	5.79519779
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.99950639
5	Hypoglycemic seizures (HP:0002173)	4.92293887
6	Abnormal biliary tract physiology (HP:0012439)	4.72507410
7	Bile duct proliferation (HP:0001408)	4.72507410
8	Hypobetalipoproteinemia (HP:0003563)	3.93002344
9	Hyperlipoproteinemia (HP:0010980)	3.78380258
10	Generalized aminoaciduria (HP:0002909)	3.57456039
11	Intrahepatic cholestasis (HP:0001406)	3.50590150
12	Abnormality of the intrinsic pathway (HP:0010989)	3.41708051
13	Abnormality of pyrimidine metabolism (HP:0004353)	3.34447393
14	Hypoplasia of the uterus (HP:0000013)	3.25628462
15	Abnormal protein glycosylation (HP:0012346)	3.24552538
16	Abnormal glycosylation (HP:0012345)	3.24552538
17	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.24552538
18	Abnormal protein N-linked glycosylation (HP:0012347)	3.24552538
19	Hypothermia (HP:0002045)	3.24476962
20	Symptomatic seizures (HP:0011145)	3.02361066
21	Male pseudohermaphroditism (HP:0000037)	2.92190832
22	Systemic lupus erythematosus (HP:0002725)	2.90144400
23	Retinal atrophy (HP:0001105)	2.89481639
24	Aplasia/hypoplasia of the uterus (HP:0008684)	2.87234327
25	Abnormal sex determination (HP:0012244)	2.86302265
26	Sex reversal (HP:0012245)	2.86302265
27	Ketosis (HP:0001946)	2.83909350
28	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.81277846
29	Hyperglycinemia (HP:0002154)	2.81152241
30	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.80709620
31	Pancreatic cysts (HP:0001737)	2.78283704
32	Protruding tongue (HP:0010808)	2.74766345
33	Pancreatic fibrosis (HP:0100732)	2.71192643
34	Abolished electroretinogram (ERG) (HP:0000550)	2.65447927
35	Chronic hepatic failure (HP:0100626)	2.61493965
36	Hyperammonemia (HP:0001987)	2.60857385
37	Renal cortical cysts (HP:0000803)	2.60334039
38	Xanthomatosis (HP:0000991)	2.59245221
39	Facial hemangioma (HP:0000329)	2.55566886
40	Complement deficiency (HP:0004431)	2.54487243
41	True hermaphroditism (HP:0010459)	2.51162105
42	Joint hemorrhage (HP:0005261)	2.49832568
43	Glomerulonephritis (HP:0000099)	2.46817010
44	Ketoacidosis (HP:0001993)	2.43921051
45	Abnormality of the renal cortex (HP:0011035)	2.42822605
46	Fair hair (HP:0002286)	2.37846365
47	Abnormality of the lumbar spine (HP:0100712)	2.37219501
48	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.34371243
49	Delayed CNS myelination (HP:0002188)	2.31230468
50	Gonadal dysgenesis (HP:0000133)	2.28841722
51	Enlarged kidneys (HP:0000105)	2.28463700
52	Type II lissencephaly (HP:0007260)	2.28170278
53	Congenital sensorineural hearing impairment (HP:0008527)	2.27476565
54	Hypolipoproteinemia (HP:0010981)	2.27430225
55	Abnormal drinking behavior (HP:0030082)	2.27239157
56	Polydipsia (HP:0001959)	2.27239157
57	Abnormality of glycine metabolism (HP:0010895)	2.25277839
58	Abnormality of serine family amino acid metabolism (HP:0010894)	2.25277839
59	Osteomalacia (HP:0002749)	2.23717657
60	Congenital stationary night blindness (HP:0007642)	2.21674165
61	Abnormal rod and cone electroretinograms (HP:0008323)	2.20325575
62	Thoracic kyphosis (HP:0002942)	2.18399242
63	Cerebellar dysplasia (HP:0007033)	2.17093460
64	Hyperventilation (HP:0002883)	2.16589080
65	Lower limb hyperreflexia (HP:0002395)	2.16410751
66	Inability to walk (HP:0002540)	2.11113152
67	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.09546454
68	Glycosuria (HP:0003076)	2.04509694
69	Abnormality of urine glucose concentration (HP:0011016)	2.04509694
70	Abnormal ciliary motility (HP:0012262)	2.04413172
71	Absent/shortened dynein arms (HP:0200106)	2.03984318
72	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03984318
73	Hyperglycinuria (HP:0003108)	2.03850733
74	Abnormal respiratory motile cilium physiology (HP:0012261)	2.03777437
75	Abnormality of serum amino acid levels (HP:0003112)	2.03703717
76	Large for gestational age (HP:0001520)	2.02630329
77	Metabolic acidosis (HP:0001942)	1.96894567
78	Arthropathy (HP:0003040)	1.93895088
79	Abnormality of the columella (HP:0009929)	1.92755122
80	Facial shape deformation (HP:0011334)	1.91903865
81	Potter facies (HP:0002009)	1.91903865
82	Abnormal urine output (HP:0012590)	1.91561077
83	Pendular nystagmus (HP:0012043)	1.90738507
84	Generalized hypopigmentation of hair (HP:0011358)	1.89399246
85	Abnormality of endocrine pancreas physiology (HP:0012093)	1.88633502
86	Abnormality of the pancreatic islet cells (HP:0006476)	1.88633502
87	Abnormality of the common coagulation pathway (HP:0010990)	1.88619685
88	Lethargy (HP:0001254)	1.87933808
89	Stomach cancer (HP:0012126)	1.85618487
90	Cystic liver disease (HP:0006706)	1.85501480
91	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.83717164
92	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.83717164
93	Pulmonary embolism (HP:0002204)	1.80024048
94	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.78587908
95	Abnormality of nucleobase metabolism (HP:0010932)	1.78530553
96	Hypoalphalipoproteinemia (HP:0003233)	1.78096925
97	Abnormality of renal excretion (HP:0011036)	1.77561772
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.77018488
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77018488
100	Abnormality of midbrain morphology (HP:0002418)	1.74144479

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.87573763
2	TLK1	5.48996869
3	FRK	4.24041397
4	ZAK	4.04506756
5	MARK3	3.63752912
6	ADRBK2	2.82110680
7	BMPR1B	2.52911796
8	GRK1	2.10799898
9	STK39	2.05501455
10	MAP4K2	1.98474999
11	EIF2AK3	1.97662817
12	RPS6KA5	1.96562435
13	WNK4	1.77252836
14	MYLK	1.67572658
15	MUSK	1.65795234
16	WNK3	1.58078633
17	STK38L	1.47318786
18	NTRK3	1.37195309
19	OXSR1	1.35174748
20	TRIM28	1.24885931
21	LATS1	1.23174600
22	STK38	1.18158277
23	PLK2	1.16899404
24	TXK	1.15056725
25	BRSK2	1.09157333
26	CASK	1.02566852
27	FGFR2	0.99418260
28	PIK3CA	0.98788157
29	PRKD2	0.93962036
30	CDK3	0.91549506
31	TEC	0.86513682
32	TGFBR1	0.81908345
33	ERBB2	0.80434394
34	PRKCQ	0.80033606
35	PAK3	0.79829856
36	MST4	0.75948524
37	BCKDK	0.74995167
38	PRKCG	0.74102594
39	WEE1	0.72842028
40	ACVR1B	0.71109621
41	MAPK13	0.70903041
42	PRKCE	0.70199992
43	VRK1	0.70123464
44	CLK1	0.69530364
45	CSNK1G3	0.69407386
46	PDK2	0.69318981
47	NEK2	0.68540043
48	CSNK1G1	0.67212890
49	TIE1	0.66997050
50	ABL2	0.66513090
51	CSNK1A1L	0.64767968
52	TAOK3	0.64663015
53	ADRBK1	0.63040172
54	PRKCI	0.58271471
55	PRKG1	0.57257229
56	INSRR	0.54365597
57	DYRK2	0.53553099
58	OBSCN	0.52642662
59	MAP2K6	0.50888509
60	BMPR2	0.49041800
61	MAP2K7	0.48281087
62	CSNK1A1	0.48183443
63	CSNK1G2	0.47843050
64	CSNK1D	0.45685365
65	NUAK1	0.44394909
66	PHKG1	0.42146531
67	PHKG2	0.42146531
68	GRK6	0.41766503
69	PTK2B	0.41403324
70	PKN1	0.40953945
71	PDPK1	0.40478191
72	PRKACA	0.40322418
73	PIK3CG	0.38975668
74	NLK	0.38418750
75	BRD4	0.37378069
76	CDK8	0.35840449
77	PRKCA	0.35604845
78	STK3	0.34973209
79	IGF1R	0.34550480
80	ERBB4	0.32759018
81	EGFR	0.31066476
82	PLK1	0.30378215
83	PLK3	0.30342304
84	ATM	0.29700146
85	IKBKB	0.29519695
86	MAP3K5	0.28774768
87	PRKACG	0.28353585
88	GRK5	0.27987774
89	FER	0.27431483
90	STK16	0.25077630
91	CDK14	0.23596583
92	MAPK15	0.23035018
93	PRKCB	0.22278913
94	SGK1	0.21541664
95	RPS6KA3	0.21035961
96	PRKACB	0.19958876
97	GRK7	0.19341592
98	CSNK2A1	0.18833751
99	TBK1	0.17256668
100	SRPK1	0.16692593

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.79166396
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.36969568
3	Steroid hormone biosynthesis_Homo sapiens_hsa00140	3.22004069
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.13663491
5	Linoleic acid metabolism_Homo sapiens_hsa00591	3.12089195
6	Retinol metabolism_Homo sapiens_hsa00830	2.91460511
7	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.64929525
8	Complement and coagulation cascades_Homo sapiens_hsa04610	2.60321796
9	Arginine biosynthesis_Homo sapiens_hsa00220	2.56560847
10	Chemical carcinogenesis_Homo sapiens_hsa05204	2.54880582
11	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.49358309
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.46673025
13	Sulfur relay system_Homo sapiens_hsa04122	2.38775820
14	Caffeine metabolism_Homo sapiens_hsa00232	2.23868826
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.22850357
16	Butanoate metabolism_Homo sapiens_hsa00650	2.12343338
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.94521686
18	Peroxisome_Homo sapiens_hsa04146	1.89961988
19	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.84817310
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.73029814
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.70243068
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.67974318
23	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.62787191
24	Phenylalanine metabolism_Homo sapiens_hsa00360	1.59672144
25	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.57453378
26	Sulfur metabolism_Homo sapiens_hsa00920	1.55167932
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.54585326
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51522798
29	Bile secretion_Homo sapiens_hsa04976	1.49770392
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.44865203
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.44858163
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.43614401
33	Fatty acid degradation_Homo sapiens_hsa00071	1.41590351
34	PPAR signaling pathway_Homo sapiens_hsa03320	1.31433858
35	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.29869054
36	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.29487099
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.22774000
38	Histidine metabolism_Homo sapiens_hsa00340	1.22653937
39	Propanoate metabolism_Homo sapiens_hsa00640	1.21047650
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20506540
41	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.14160005
42	Tyrosine metabolism_Homo sapiens_hsa00350	1.06550491
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.05152524
44	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04871657
45	Pyruvate metabolism_Homo sapiens_hsa00620	1.04607403
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.02794798
47	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.97904570
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97565632
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.85781950
50	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.81361541
51	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.78827219
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.77637791
53	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.77509949
54	Metabolic pathways_Homo sapiens_hsa01100	0.64918694
55	Glutathione metabolism_Homo sapiens_hsa00480	0.61961128
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.61328649
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.60204243
58	ABC transporters_Homo sapiens_hsa02010	0.57767362
59	Phototransduction_Homo sapiens_hsa04744	0.53968610
60	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53366126
61	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.51585458
62	Gap junction_Homo sapiens_hsa04540	0.51046280
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50682830
64	One carbon pool by folate_Homo sapiens_hsa00670	0.48248894
65	Olfactory transduction_Homo sapiens_hsa04740	0.47037542
66	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.45912305
67	Fatty acid elongation_Homo sapiens_hsa00062	0.43170275
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40795264
69	Carbon metabolism_Homo sapiens_hsa01200	0.40727483
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38647167
71	Lysine degradation_Homo sapiens_hsa00310	0.38429610
72	Sphingolipid metabolism_Homo sapiens_hsa00600	0.38205137
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.37614307
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36008082
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34967221
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.32104789
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.29233620
78	Phagosome_Homo sapiens_hsa04145	0.28730781
79	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.23541717
80	Regulation of autophagy_Homo sapiens_hsa04140	0.23174116
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.22531550
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22465946
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.21280612
84	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.20473134
85	Serotonergic synapse_Homo sapiens_hsa04726	0.20014774
86	Apoptosis_Homo sapiens_hsa04210	0.19215704
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.17930015
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.15653703
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.13850420
90	Taste transduction_Homo sapiens_hsa04742	0.12616435
91	Graft-versus-host disease_Homo sapiens_hsa05332	0.12511098
92	Insulin secretion_Homo sapiens_hsa04911	0.12161544
93	Asthma_Homo sapiens_hsa05310	0.11851429
94	Alcoholism_Homo sapiens_hsa05034	0.10269670
95	Renin-angiotensin system_Homo sapiens_hsa04614	0.09701792
96	Basal transcription factors_Homo sapiens_hsa03022	0.08562416
97	Collecting duct acid secretion_Homo sapiens_hsa04966	0.06601105
98	Pancreatic secretion_Homo sapiens_hsa04972	0.05632738
99	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.04681502
100	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.04577393

TEX13C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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