ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sister chromatid cohesion (GO:0007062)	8.19820236
2	meiotic cell cycle process (GO:1903046)	7.94267878
3	meiotic chromosome segregation (GO:0045132)	7.46934400
4	regulation of meiosis I (GO:0060631)	7.26307962
5	histone H3-K36 demethylation (GO:0070544)	6.56712947
6	histone H3-K9 demethylation (GO:0033169)	6.53746217
7	reciprocal meiotic recombination (GO:0007131)	6.37667646
8	reciprocal DNA recombination (GO:0035825)	6.37667646
9	resolution of meiotic recombination intermediates (GO:0000712)	5.46948837
10	positive regulation of cellular response to oxidative stress (GO:1900409)	5.16373024
11	positive regulation of response to oxidative stress (GO:1902884)	5.16373024
12	gene silencing by RNA (GO:0031047)	5.15300665
13	regulation of DNA endoreduplication (GO:0032875)	4.72276295
14	female gamete generation (GO:0007292)	4.71390370
15	regulation of histone H3-K9 methylation (GO:0051570)	4.63424681
16	negative regulation of gene silencing (GO:0060969)	4.54903034
17	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	4.35035097
18	spermatid development (GO:0007286)	4.26165052
19	positive regulation of meiosis (GO:0045836)	4.23497010
20	DNA methylation (GO:0006306)	4.21183080
21	DNA alkylation (GO:0006305)	4.21183080
22	negative regulation of inclusion body assembly (GO:0090084)	4.19889457
23	regulation of transcription from RNA polymerase I promoter (GO:0006356)	4.16631135
24	regulation of meiotic cell cycle (GO:0051445)	4.13101498
25	attachment of spindle microtubules to kinetochore (GO:0008608)	4.11594216
26	embryonic body morphogenesis (GO:0010172)	4.03691306
27	positive regulation of meiotic cell cycle (GO:0051446)	4.00143294
28	mitotic sister chromatid cohesion (GO:0007064)	3.92898290
29	meiotic cell cycle (GO:0051321)	3.88263084
30	genitalia morphogenesis (GO:0035112)	3.79341568
31	protein localization to chromosome (GO:0034502)	3.77778834
32	reproductive system development (GO:0061458)	3.68417911
33	sex differentiation (GO:0007548)	3.56420051
34	chromosome organization (GO:0051276)	3.48320564
35	regulation of microtubule-based movement (GO:0060632)	3.43454011
36	mitotic spindle assembly checkpoint (GO:0007094)	3.43186660
37	histone H2A acetylation (GO:0043968)	3.43039609
38	signal complex assembly (GO:0007172)	3.43018342
39	germ cell development (GO:0007281)	3.40506503
40	histone lysine demethylation (GO:0070076)	3.38134214
41	DNA biosynthetic process (GO:0071897)	3.37181197
42	spindle assembly checkpoint (GO:0071173)	3.33836729
43	histone demethylation (GO:0016577)	3.33526803
44	binding of sperm to zona pellucida (GO:0007339)	3.32260106
45	negative regulation of meiosis (GO:0045835)	3.28737145
46	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.24161493
47	negative regulation of sister chromatid segregation (GO:0033046)	3.24161493
48	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.24161493
49	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.24161493
50	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.24161493
51	body morphogenesis (GO:0010171)	3.21007806
52	mitotic spindle checkpoint (GO:0071174)	3.20542075
53	oogenesis (GO:0048477)	3.17868303
54	fertilization (GO:0009566)	3.17584374
55	interkinetic nuclear migration (GO:0022027)	3.17387715
56	DNA methylation or demethylation (GO:0044728)	3.16666772
57	nuclear division (GO:0000280)	3.14376583
58	growth hormone receptor signaling pathway (GO:0060396)	3.13329553
59	histone H4-K12 acetylation (GO:0043983)	3.13145683
60	regulation of meiosis (GO:0040020)	3.11906344
61	negative regulation of chromosome segregation (GO:0051985)	3.10175835
62	protein dealkylation (GO:0008214)	3.07667764
63	protein demethylation (GO:0006482)	3.07667764
64	diterpenoid biosynthetic process (GO:0016102)	3.05478005
65	regulation of sister chromatid segregation (GO:0033045)	3.02793448
66	regulation of mitotic sister chromatid separation (GO:0010965)	3.02793448
67	regulation of mitotic sister chromatid segregation (GO:0033047)	3.02793448
68	histone exchange (GO:0043486)	3.00366790
69	protein refolding (GO:0042026)	2.99318914
70	acrosome reaction (GO:0007340)	2.97730086
71	response to misfolded protein (GO:0051788)	2.95292064
72	spindle checkpoint (GO:0031577)	2.93786909
73	organelle fission (GO:0048285)	2.91907320
74	gene silencing (GO:0016458)	2.91496257
75	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.90164736
76	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.90164736
77	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.80431261
78	spermatogenesis (GO:0007283)	2.78184354
79	male gamete generation (GO:0048232)	2.78113848
80	cellular response to growth hormone stimulus (GO:0071378)	2.77056456
81	intraciliary transport (GO:0042073)	2.77054655
82	regulation of cilium movement (GO:0003352)	2.76910398
83	gamete generation (GO:0007276)	2.76348066
84	regulation of chromatin silencing (GO:0031935)	2.72079781
85	regulation of protein polyubiquitination (GO:1902914)	2.70941007
86	vitamin A metabolic process (GO:0006776)	2.70781863
87	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.66434641
88	mitotic chromosome condensation (GO:0007076)	2.65910454
89	sperm-egg recognition (GO:0035036)	2.64166436
90	synapsis (GO:0007129)	16.1406811
91	chromosome organization involved in meiosis (GO:0070192)	14.2069573
92	male meiosis I (GO:0007141)	14.1316616
93	synaptonemal complex assembly (GO:0007130)	13.2652870
94	piRNA metabolic process (GO:0034587)	13.1545142
95	male meiosis (GO:0007140)	12.1039835
96	synaptonemal complex organization (GO:0070193)	12.0300323
97	meiosis I (GO:0007127)	11.4412004
98	meiotic nuclear division (GO:0007126)	10.7025989
99	DNA methylation involved in gamete generation (GO:0043046)	10.6704173
100	DNA synthesis involved in DNA repair (GO:0000731)	10.4867266

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	6.28610579
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.36980734
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.07339632
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.32220133
5	RNF2_27304074_Chip-Seq_NSC_Mouse	3.18385022
6	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.83258658
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.81070720
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.60438018
9	FUS_26573619_Chip-Seq_HEK293_Human	2.38364283
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.31004736
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20461592
12	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.19876505
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.11626724
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.04870561
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.98815842
16	VDR_22108803_ChIP-Seq_LS180_Human	1.97836435
17	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.94567666
18	BCAT_22108803_ChIP-Seq_LS180_Human	1.93605179
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.83528123
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77515482
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.74706296
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73617066
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.70868616
24	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.68872146
25	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.68597301
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.62062312
27	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.56985848
28	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.54091750
29	AR_25329375_ChIP-Seq_VCAP_Human	1.53031296
30	EWS_26573619_Chip-Seq_HEK293_Human	1.51761805
31	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.51385038
32	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.51335488
33	RUNX2_22187159_ChIP-Seq_PCA_Human	1.42270177
34	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.40281216
35	E2F7_22180533_ChIP-Seq_HELA_Human	1.39934669
36	ERA_21632823_ChIP-Seq_H3396_Human	1.37871124
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.37065158
38	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.32182133
39	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.31843016
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31705301
41	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.31090877
42	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30683128
43	GATA3_26560356_Chip-Seq_TH1_Human	1.29023909
44	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.28578441
45	STAT3_23295773_ChIP-Seq_U87_Human	1.28471582
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27405706
47	TCF4_23295773_ChIP-Seq_U87_Human	1.27014829
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25340003
49	P300_19829295_ChIP-Seq_ESCs_Human	1.24854995
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.24465264
51	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.24451870
52	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.23072416
53	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23039213
54	HOXB7_26014856_ChIP-Seq_BT474_Human	1.22222286
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.20361592
56	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.20274038
57	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20196962
58	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.18969444
59	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.18325065
60	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18059994
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18059994
62	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.17751325
63	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.13783492
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12628609
65	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12498015
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10963591
67	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10695696
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09287221
69	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.09108475
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09074672
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09074672
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.07260397
73	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06648238
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.06648238
75	MYC_19829295_ChIP-Seq_ESCs_Human	1.06599898
76	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01790337
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00727527
78	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99914158
79	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.99837847
80	SMAD4_21799915_ChIP-Seq_A2780_Human	0.99826018
81	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.99764007
82	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99532493
83	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99506605
84	GBX2_23144817_ChIP-Seq_PC3_Human	0.99059341
85	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98306556
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96510405
87	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95651050
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95651050
89	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.94263887
90	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.94263887
91	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.94263887
92	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93590265
93	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93404171
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.91599450
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90798884
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.90274428
97	ETV1_20927104_ChIP-Seq_GIST48_Human	0.89665836
98	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.89327680
99	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89314910
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.88538607

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002210_abnormal_sex_determination	5.01823858
2	MP0001929_abnormal_gametogenesis	4.37323678
3	MP0002160_abnormal_reproductive_system	4.15745796
4	MP0003698_abnormal_male_reproductive	3.84876945
5	MP0001145_abnormal_male_reproductive	3.72984091
6	MP0008058_abnormal_DNA_repair	3.55519370
7	MP0000653_abnormal_sex_gland	3.39400186
8	MP0008995_early_reproductive_senescence	2.87560786
9	MP0005389_reproductive_system_phenotype	2.73735183
10	MP0005410_abnormal_fertilization	2.71346644
11	MP0000678_abnormal_parathyroid_gland	2.66248030
12	MP0008004_abnormal_stomach_pH	2.54655737
13	MP0003693_abnormal_embryo_hatching	2.18532544
14	MP0002161_abnormal_fertility/fecundity	2.13810258
15	MP0008789_abnormal_olfactory_epithelium	2.12736428
16	MP0000383_abnormal_hair_follicle	2.11638921
17	MP0001119_abnormal_female_reproductive	2.10379321
18	MP0008877_abnormal_DNA_methylation	10.0158384
19	MP0003646_muscle_fatigue	1.92867114
20	MP0000569_abnormal_digit_pigmentation	1.89541774
21	MP0000427_abnormal_hair_cycle	1.84724299
22	MP0003718_maternal_effect	1.78449297
23	MP0003699_abnormal_female_reproductive	1.76240342
24	MP0010094_abnormal_chromosome_stability	1.74196655
25	MP0005499_abnormal_olfactory_system	1.60940405
26	MP0005394_taste/olfaction_phenotype	1.60940405
27	MP0005174_abnormal_tail_pigmentation	1.50107070
28	MP0010678_abnormal_skin_adnexa	1.47509821
29	MP0001661_extended_life_span	1.43903468
30	MP0005647_abnormal_sex_gland	1.43679939
31	MP0003119_abnormal_digestive_system	1.43118871
32	MP0000015_abnormal_ear_pigmentation	1.41469820
33	MP0001984_abnormal_olfaction	1.40257822
34	MP0003786_premature_aging	1.36903458
35	MP0003111_abnormal_nucleus_morphology	1.27918632
36	MP0006035_abnormal_mitochondrial_morpho	1.22155865
37	MP0008007_abnormal_cellular_replicative	1.14322661
38	MP0001188_hyperpigmentation	1.12725524
39	MP0003077_abnormal_cell_cycle	1.07464080
40	MP0003890_abnormal_embryonic-extraembry	1.05247753
41	MP0001919_abnormal_reproductive_system	1.01744148
42	MP0003937_abnormal_limbs/digits/tail_de	1.01633621
43	MP0002095_abnormal_skin_pigmentation	0.97097158
44	MP0005409_darkened_coat_color	0.94990010
45	MP0003936_abnormal_reproductive_system	0.94098201
46	MP0010307_abnormal_tumor_latency	0.92530032
47	MP0003943_abnormal_hepatobiliary_system	0.91869282
48	MP0005645_abnormal_hypothalamus_physiol	0.91094627
49	MP0002638_abnormal_pupillary_reflex	0.90939377
50	MP0003938_abnormal_ear_development	0.83776847
51	MP0002084_abnormal_developmental_patter	0.80228729
52	MP0000631_abnormal_neuroendocrine_gland	0.79633154
53	MP0003183_abnormal_peptide_metabolism	0.77400752
54	MP0005310_abnormal_salivary_gland	0.77071597
55	MP0006276_abnormal_autonomic_nervous	0.76151222
56	MP0003123_paternal_imprinting	0.74884473
57	MP0002249_abnormal_larynx_morphology	0.71715020
58	MP0004019_abnormal_vitamin_homeostasis	0.71196365
59	MP0000647_abnormal_sebaceous_gland	0.69320326
60	MP0010030_abnormal_orbit_morphology	0.69193468
61	MP0001485_abnormal_pinna_reflex	0.68171859
62	MP0005551_abnormal_eye_electrophysiolog	0.67457353
63	MP0000778_abnormal_nervous_system	0.66955024
64	MP0009703_decreased_birth_body	0.66159239
65	MP0003136_yellow_coat_color	0.65383603
66	MP0008057_abnormal_DNA_replication	0.65023797
67	MP0001664_abnormal_digestion	0.61840961
68	MP0001730_embryonic_growth_arrest	0.59159544
69	MP0004036_abnormal_muscle_relaxation	0.59117164
70	MP0001243_abnormal_dermal_layer	0.58657929
71	MP0001697_abnormal_embryo_size	0.57984578
72	MP0000013_abnormal_adipose_tissue	0.57722873
73	MP0006292_abnormal_olfactory_placode	0.54508220
74	MP0003941_abnormal_skin_development	0.53629615
75	MP0008932_abnormal_embryonic_tissue	0.53402677
76	MP0000358_abnormal_cell_content/	0.53247954
77	MP0001529_abnormal_vocalization	0.53046668
78	MP0002282_abnormal_trachea_morphology	0.52923344
79	MP0003315_abnormal_perineum_morphology	0.52633895
80	MP0002184_abnormal_innervation	0.52205554
81	MP0002139_abnormal_hepatobiliary_system	0.51070451
82	MP0002653_abnormal_ependyma_morphology	0.51056930
83	MP0004808_abnormal_hematopoietic_stem	0.50495651
84	MP0002233_abnormal_nose_morphology	0.49220782
85	MP0004742_abnormal_vestibular_system	0.48572299
86	MP0005167_abnormal_blood-brain_barrier	0.45561345
87	MP0002067_abnormal_sensory_capabilities	0.45151242
88	MP0009697_abnormal_copulation	0.44276166
89	MP0003861_abnormal_nervous_system	0.42951825
90	MP0002085_abnormal_embryonic_tissue	0.42832818
91	MP0000313_abnormal_cell_death	0.42118636
92	MP0002132_abnormal_respiratory_system	0.41949793
93	MP0000579_abnormal_nail_morphology	0.40495362
94	MP0001502_abnormal_circadian_rhythm	0.39832822
95	MP0005253_abnormal_eye_physiology	0.38258911
96	MP0005395_other_phenotype	0.37237733
97	MP0010368_abnormal_lymphatic_system	0.35771597
98	MP0005380_embryogenesis_phenotype	0.35446016
99	MP0001672_abnormal_embryogenesis/_devel	0.35446016
100	MP0002177_abnormal_outer_ear	0.35306442

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oligodactyly (hands) (HP:0001180)	5.99772269
2	Gonadotropin excess (HP:0000837)	5.36390907
3	Azoospermia (HP:0000027)	4.91014636
4	Volvulus (HP:0002580)	4.87792280
5	Shoulder girdle muscle weakness (HP:0003547)	4.75666023
6	Spontaneous abortion (HP:0005268)	4.58564687
7	Horizontal nystagmus (HP:0000666)	4.56911908
8	Tubulointerstitial nephritis (HP:0001970)	4.25698920
9	Facial hemangioma (HP:0000329)	4.12165953
10	Oligodactyly (HP:0012165)	4.11635342
11	Rimmed vacuoles (HP:0003805)	4.08959400
12	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.01644284
13	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.01644284
14	Type I transferrin isoform profile (HP:0003642)	4.00335375
15	Abnormal protein glycosylation (HP:0012346)	3.95963182
16	Abnormal glycosylation (HP:0012345)	3.95963182
17	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.95963182
18	Abnormal protein N-linked glycosylation (HP:0012347)	3.95963182
19	Amyotrophic lateral sclerosis (HP:0007354)	3.77589492
20	Abnormal spermatogenesis (HP:0008669)	3.75583222
21	Increased nuchal translucency (HP:0010880)	3.72464221
22	11 pairs of ribs (HP:0000878)	3.61172260
23	Broad distal phalanx of finger (HP:0009836)	3.39781870
24	Abnormality of the lower motor neuron (HP:0002366)	3.30489078
25	Ectopic kidney (HP:0000086)	3.14276631
26	Capillary hemangiomas (HP:0005306)	3.12719248
27	Short nail (HP:0001799)	3.05276365
28	Chromsome breakage (HP:0040012)	2.99240853
29	Wrist flexion contracture (HP:0001239)	2.98604198
30	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.93078071
31	Hypoplastic iliac wings (HP:0002866)	2.91012300
32	Abnormality of the corticospinal tract (HP:0002492)	2.88517053
33	Nephroblastoma (Wilms tumor) (HP:0002667)	2.81341844
34	Abnormality of DNA repair (HP:0003254)	2.80207810
35	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.78921888
36	Abnormal lung lobation (HP:0002101)	2.76499597
37	Supernumerary spleens (HP:0009799)	2.74830047
38	Small intestinal stenosis (HP:0012848)	2.74317967
39	Duodenal stenosis (HP:0100867)	2.74317967
40	Embryonal renal neoplasm (HP:0011794)	2.69595689
41	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.69169857
42	Metaphyseal cupping (HP:0003021)	2.60395243
43	Enlarged penis (HP:0000040)	2.59143265
44	Abnormality of the labia minora (HP:0012880)	2.59074685
45	Abnormality of chromosome segregation (HP:0002916)	2.56680627
46	Impaired vibration sensation in the lower limbs (HP:0002166)	2.56611012
47	Medial flaring of the eyebrow (HP:0010747)	2.49592961
48	Large hands (HP:0001176)	2.43598230
49	Nephronophthisis (HP:0000090)	2.43435258
50	Abnormality of the renal medulla (HP:0100957)	2.42315944
51	Congenital primary aphakia (HP:0007707)	2.37631457
52	Fibular hypoplasia (HP:0003038)	2.35765473
53	Gait imbalance (HP:0002141)	2.34790717
54	Resting tremor (HP:0002322)	2.34740922
55	Non-midline cleft lip (HP:0100335)	2.31622153
56	Multicystic kidney dysplasia (HP:0000003)	2.30756604
57	Upper motor neuron abnormality (HP:0002127)	2.28301904
58	Abnormality of the duodenum (HP:0002246)	2.24601768
59	Widely spaced teeth (HP:0000687)	2.24468499
60	Nephrogenic diabetes insipidus (HP:0009806)	2.23079115
61	Urinary urgency (HP:0000012)	2.08889561
62	Duplicated collecting system (HP:0000081)	2.08309264
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07600928
64	Abnormality of alanine metabolism (HP:0010916)	2.07600928
65	Hyperalaninemia (HP:0003348)	2.07600928
66	Type II lissencephaly (HP:0007260)	2.04446568
67	Abnormality of chromosome stability (HP:0003220)	2.03593470
68	Osteomalacia (HP:0002749)	1.99774147
69	Fair hair (HP:0002286)	1.99223904
70	Abnormality of the renal collecting system (HP:0004742)	1.98807086
71	Male infertility (HP:0003251)	1.97092156
72	Poor coordination (HP:0002370)	1.96659941
73	Preaxial hand polydactyly (HP:0001177)	1.95673288
74	Cystic liver disease (HP:0006706)	1.89919908
75	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89644469
76	Scotoma (HP:0000575)	1.89165312
77	Flattened epiphyses (HP:0003071)	1.86847518
78	Lip pit (HP:0100267)	1.85586840
79	Limb-girdle muscle weakness (HP:0003325)	1.85226797
80	Molar tooth sign on MRI (HP:0002419)	1.84652065
81	Abnormality of midbrain morphology (HP:0002418)	1.84652065
82	Abnormality of permanent molar morphology (HP:0011071)	1.83823528
83	Abnormality of the dental root (HP:0006486)	1.83823528
84	Taurodontia (HP:0000679)	1.83823528
85	Tubulointerstitial abnormality (HP:0001969)	1.82619809
86	Abnormality of the labia (HP:0000058)	1.77075835
87	Truncal obesity (HP:0001956)	1.77027411
88	Infertility (HP:0000789)	1.74923769
89	Hyperkalemia (HP:0002153)	1.74353343
90	Abnormality of the vocal cords (HP:0008777)	1.73000263
91	Astigmatism (HP:0000483)	1.72196561
92	Absent radius (HP:0003974)	1.70448711
93	Meckel diverticulum (HP:0002245)	1.70299441
94	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.70190453
95	Hyperpituitarism (HP:0010514)	1.69903950
96	Rhizomelia (HP:0008905)	1.69440319
97	Abnormality of molar morphology (HP:0011070)	1.68580231
98	Abnormality of molar (HP:0011077)	1.68580231
99	Genital tract atresia (HP:0001827)	1.68224793
100	Proximal placement of thumb (HP:0009623)	1.68002292

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	9.62185637
2	MET	5.11930625
3	CDK19	4.36743983
4	PTK2B	3.14252822
5	FGR	3.04976085
6	BMX	2.97782101
7	PDK2	2.80255099
8	CAMK1G	2.75801358
9	CSF1R	2.49863012
10	OXSR1	2.35800678
11	PINK1	2.09107411
12	ZAK	2.00620508
13	PLK2	1.94227872
14	PLK4	1.77819660
15	NEK9	1.64806665
16	RET	1.56929694
17	TTK	1.54475461
18	PDGFRB	1.47020841
19	MARK3	1.37221238
20	STK38L	1.36187170
21	CASK	1.31723136
22	NEK1	1.26024104
23	STK16	1.22493446
24	PLK1	1.10310495
25	WEE1	1.06860849
26	PRKCI	1.06676933
27	BRAF	1.01756519
28	KSR1	1.00212129
29	MAP3K13	1.00043133
30	MAP3K9	0.93155274
31	TYRO3	0.83753566
32	EGFR	0.81862904
33	ATR	0.80663968
34	VRK1	0.80546436
35	PTK2	0.79327834
36	MAP3K4	0.79289781
37	PASK	0.77756953
38	ARAF	0.73787171
39	CHEK1	0.72773042
40	MST1R	0.69250287
41	MAP3K5	0.68470351
42	ATM	0.67173467
43	NEK2	0.66918002
44	CDK3	0.66859354
45	MAPK13	0.66008227
46	STK11	0.63978942
47	TAF1	0.60126351
48	RPS6KB1	0.58488726
49	TLK1	0.55618304
50	SGK1	0.54646085
51	TSSK6	0.51870191
52	STK38	0.51680315
53	TRIM28	0.50886222
54	ROCK1	0.50764620
55	MAP3K2	0.50753240
56	CDK6	0.50012984
57	PDK1	0.50004518
58	MAP3K10	0.47269480
59	NEK6	0.45430815
60	AURKA	0.44928878
61	WNK3	0.44637158
62	RPS6KA5	0.44118530
63	PDPK1	0.42465728
64	CDK11A	0.42188532
65	AKT2	0.41958397
66	AKT3	0.40283208
67	NUAK1	0.39879229
68	MELK	0.39490536
69	CSNK1E	0.35076913
70	CAMK1	0.33184594
71	MAP2K7	0.32875024
72	DYRK3	0.32604394
73	CDK5	0.31256899
74	YES1	0.31088511
75	IGF1R	0.29802158
76	KSR2	0.29451877
77	ADRBK2	0.27088883
78	RAF1	0.26843024
79	NTRK3	0.26810296
80	CDK7	0.26595961
81	EPHA4	0.25825045
82	PRKG1	0.25335834
83	CDK1	0.24210576
84	WNK4	0.22925147
85	CDK2	0.20542686
86	CHEK2	0.20182690
87	CDK9	0.20030372
88	CDK14	0.18871383
89	WNK1	0.18480767
90	DYRK1A	0.15549891
91	ACVR1B	0.15499462
92	MINK1	0.15491811
93	PRKCZ	0.15236056
94	MOS	0.14813951
95	FRK	0.14469646
96	MAPK1	0.14339055
97	EIF2AK3	0.14209460
98	MAP2K2	0.12366769
99	PRKDC	0.12318029
100	STK3	0.12297757

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	4.73521625
2	Homologous recombination_Homo sapiens_hsa03440	4.50737657
3	Oocyte meiosis_Homo sapiens_hsa04114	3.83169531
4	Mismatch repair_Homo sapiens_hsa03430	3.59115831
5	Cell cycle_Homo sapiens_hsa04110	3.52459070
6	RNA transport_Homo sapiens_hsa03013	3.10754988
7	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	3.08932193
8	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.99170316
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.97375971
10	DNA replication_Homo sapiens_hsa03030	2.88565947
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.79957630
12	mRNA surveillance pathway_Homo sapiens_hsa03015	2.58197714
13	RNA degradation_Homo sapiens_hsa03018	2.55377850
14	Regulation of autophagy_Homo sapiens_hsa04140	2.35465614
15	Basal transcription factors_Homo sapiens_hsa03022	2.27546449
16	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.90787761
17	Non-homologous end-joining_Homo sapiens_hsa03450	1.80652606
18	Base excision repair_Homo sapiens_hsa03410	1.80198518
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57278791
20	Propanoate metabolism_Homo sapiens_hsa00640	1.53653597
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.33207841
22	Lysine degradation_Homo sapiens_hsa00310	1.12642831
23	p53 signaling pathway_Homo sapiens_hsa04115	1.03589237
24	Butanoate metabolism_Homo sapiens_hsa00650	1.02561676
25	Phototransduction_Homo sapiens_hsa04744	1.02478398
26	Small cell lung cancer_Homo sapiens_hsa05222	1.00632248
27	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97814700
28	Circadian rhythm_Homo sapiens_hsa04710	0.95117702
29	Gap junction_Homo sapiens_hsa04540	0.94356379
30	Alcoholism_Homo sapiens_hsa05034	0.90152744
31	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88278426
32	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84226560
33	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.81802514
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.81315071
35	Retinol metabolism_Homo sapiens_hsa00830	0.80371249
36	Choline metabolism in cancer_Homo sapiens_hsa05231	0.75969959
37	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.73337628
38	ErbB signaling pathway_Homo sapiens_hsa04012	0.72782276
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.71427540
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69352117
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.68606383
42	Calcium signaling pathway_Homo sapiens_hsa04020	0.68514539
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.65843672
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65747540
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63816255
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63627652
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.63592228
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61555882
49	Peroxisome_Homo sapiens_hsa04146	0.60822713
50	Phenylalanine metabolism_Homo sapiens_hsa00360	0.60688984
51	Olfactory transduction_Homo sapiens_hsa04740	0.60205592
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.57260936
53	Spliceosome_Homo sapiens_hsa03040	0.56893512
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.56675427
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56234485
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.56012864
57	HTLV-I infection_Homo sapiens_hsa05166	0.49707681
58	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.48471284
59	Parkinsons disease_Homo sapiens_hsa05012	0.47558849
60	ABC transporters_Homo sapiens_hsa02010	0.46478848
61	Viral carcinogenesis_Homo sapiens_hsa05203	0.45846712
62	Nicotine addiction_Homo sapiens_hsa05033	0.45545602
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.45305459
64	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.44919088
65	Huntingtons disease_Homo sapiens_hsa05016	0.44011745
66	mTOR signaling pathway_Homo sapiens_hsa04150	0.42945546
67	Caffeine metabolism_Homo sapiens_hsa00232	0.42854610
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42353299
69	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.41816929
70	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.41229546
71	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.41195618
72	MAPK signaling pathway_Homo sapiens_hsa04010	0.40231380
73	Apoptosis_Homo sapiens_hsa04210	0.37536323
74	Protein export_Homo sapiens_hsa03060	0.36568564
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36397918
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33838894
77	Taste transduction_Homo sapiens_hsa04742	0.33630526
78	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33606296
79	VEGF signaling pathway_Homo sapiens_hsa04370	0.33318084
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.33067641
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.31616489
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.31422330
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.31294316
84	Type II diabetes mellitus_Homo sapiens_hsa04930	0.31215539
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.29308787
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.29256650
87	Antigen processing and presentation_Homo sapiens_hsa04612	0.28753162
88	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.28704522
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28060282
90	Purine metabolism_Homo sapiens_hsa00230	0.27746547
91	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.24782117
92	Glucagon signaling pathway_Homo sapiens_hsa04922	0.23347572
93	Legionellosis_Homo sapiens_hsa05134	0.23252351
94	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.21835711
95	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.20201271
96	Tryptophan metabolism_Homo sapiens_hsa00380	0.19727148
97	Fatty acid degradation_Homo sapiens_hsa00071	0.19530061
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.17369102
99	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.17129597
100	Endocytosis_Homo sapiens_hsa04144	0.14420397

TEX13D

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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