TEX14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)8.68141847
2synaptonemal complex assembly (GO:0007130)8.10339394
3synaptonemal complex organization (GO:0070193)7.60503552
4regulation of meiosis I (GO:0060631)7.54772914
5* male meiosis (GO:0007140)6.88410035
6chromosome organization involved in meiosis (GO:0070192)6.17502622
7nuclear pore complex assembly (GO:0051292)6.02742353
8nuclear pore organization (GO:0006999)5.97998356
9* meiotic nuclear division (GO:0007126)5.76583154
10histone H3-K9 demethylation (GO:0033169)5.68772534
11male meiosis I (GO:0007141)5.40991776
12gene silencing by RNA (GO:0031047)5.37252560
13protein K11-linked deubiquitination (GO:0035871)4.95898947
14meiotic chromosome segregation (GO:0045132)4.92808653
15DNA alkylation (GO:0006305)4.80720375
16DNA methylation (GO:0006306)4.80720375
17meiotic cell cycle process (GO:1903046)4.64178084
18meiosis I (GO:0007127)4.59705695
19histone H3-K36 demethylation (GO:0070544)4.59661125
20pore complex assembly (GO:0046931)4.56509367
21heterochromatin organization (GO:0070828)4.48699433
22cilium or flagellum-dependent cell motility (GO:0001539)4.43745695
23reciprocal DNA recombination (GO:0035825)4.38758187
24reciprocal meiotic recombination (GO:0007131)4.38758187
25DNA replication-dependent nucleosome assembly (GO:0006335)4.25579303
26DNA replication-dependent nucleosome organization (GO:0034723)4.25579303
27fusion of sperm to egg plasma membrane (GO:0007342)4.22476504
28regulation of histone H3-K9 methylation (GO:0051570)4.20032533
29oogenesis (GO:0048477)4.16822205
30protein K6-linked ubiquitination (GO:0085020)4.16644189
31negative regulation of meiosis (GO:0045835)4.15686591
32regulation of centriole replication (GO:0046599)4.15284997
33sister chromatid cohesion (GO:0007062)4.14460528
34gene silencing (GO:0016458)4.12607880
35regulation of meiotic cell cycle (GO:0051445)4.10825115
36regulation of gene silencing by miRNA (GO:0060964)4.04926626
37regulation of gene silencing by RNA (GO:0060966)4.04926626
38regulation of posttranscriptional gene silencing (GO:0060147)4.04926626
39meiotic cell cycle (GO:0051321)4.04690240
40mitotic chromosome condensation (GO:0007076)3.96276366
41negative regulation of inclusion body assembly (GO:0090084)3.93841375
42DNA methylation or demethylation (GO:0044728)3.92902907
43binding of sperm to zona pellucida (GO:0007339)3.91412294
44mitotic nuclear envelope disassembly (GO:0007077)3.90623356
45histone H4-K12 acetylation (GO:0043983)3.90212546
46regulation of DNA endoreduplication (GO:0032875)3.86904069
47mitotic sister chromatid cohesion (GO:0007064)3.86044015
48synapsis (GO:0007129)3.85939515
49sperm-egg recognition (GO:0035036)3.85576193
50spermatid development (GO:0007286)3.83300686
51kinetochore organization (GO:0051383)3.76826372
52fertilization (GO:0009566)3.75584727
53detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.69541411
54membrane disassembly (GO:0030397)3.67916213
55nuclear envelope disassembly (GO:0051081)3.67916213
56microtubule depolymerization (GO:0007019)3.67597391
57germ cell development (GO:0007281)3.63306485
58regulation of helicase activity (GO:0051095)3.59041964
59protein localization to chromosome (GO:0034502)3.57319358
60mitotic metaphase plate congression (GO:0007080)3.53260772
61DNA synthesis involved in DNA repair (GO:0000731)3.53213304
62metaphase plate congression (GO:0051310)3.52511111
63female gamete generation (GO:0007292)3.51307015
64DNA replication checkpoint (GO:0000076)3.49522709
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.49414452
66regulation of mitotic spindle checkpoint (GO:1903504)3.49414452
67regulation of protein polyubiquitination (GO:1902914)3.49359287
68acrosome reaction (GO:0007340)3.49251365
69positive regulation of meiosis (GO:0045836)3.48594357
70resolution of meiotic recombination intermediates (GO:0000712)3.47193468
71cell-cell recognition (GO:0009988)3.44354500
72kinetochore assembly (GO:0051382)3.44276729
73sperm motility (GO:0030317)3.42266490
74sex differentiation (GO:0007548)3.38932591
75negative regulation of DNA repair (GO:0045738)3.38181935
76auditory behavior (GO:0031223)3.37951597
77chromatin remodeling at centromere (GO:0031055)3.36009566
78histone exchange (GO:0043486)3.34994883
79regulation of centrosome cycle (GO:0046605)3.34576463
80genitalia morphogenesis (GO:0035112)3.33551541
81negative regulation of gene silencing (GO:0060969)3.32473901
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32414076
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.32414076
84positive regulation of mitotic sister chromatid separation (GO:1901970)3.32226245
85positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32226245
86positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32226245
87pre-miRNA processing (GO:0031054)3.31649543
88acrosome assembly (GO:0001675)3.30104657
89monoubiquitinated protein deubiquitination (GO:0035520)3.28802696
90DNA modification (GO:0006304)3.27811006
91seminiferous tubule development (GO:0072520)3.27468108
92regulation of meiosis (GO:0040020)3.26201000
93positive regulation of meiotic cell cycle (GO:0051446)3.26182459
94protein localization to kinetochore (GO:0034501)3.26029160
95DNA packaging (GO:0006323)3.25136479
96DNA replication initiation (GO:0006270)3.24468025
97male gamete generation (GO:0048232)3.22708890
98protein localization to chromosome, centromeric region (GO:0071459)3.22467151
99spermatogenesis (GO:0007283)3.22365450
100chromosome organization (GO:0051276)3.22146327
101oocyte development (GO:0048599)3.21413730
102regulation of RNA export from nucleus (GO:0046831)3.21013240
103chaperone-mediated protein complex assembly (GO:0051131)3.19244381
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18128968
105negative regulation of histone methylation (GO:0031061)3.18035442
106histone demethylation (GO:0016577)3.17451840
107regulation of T-helper 2 cell differentiation (GO:0045628)3.15425533
108histone H3-K9 methylation (GO:0051567)3.14517143
109chromatin assembly (GO:0031497)3.14466146
110positive regulation of chromosome segregation (GO:0051984)3.14201962
111inner cell mass cell proliferation (GO:0001833)3.13106634
112regulation of double-strand break repair (GO:2000779)3.12834442
113histone lysine demethylation (GO:0070076)3.12605047
114negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.11772976
115axonemal dynein complex assembly (GO:0070286)3.11086534
116mitotic sister chromatid segregation (GO:0000070)3.08279094
117chromosome condensation (GO:0030261)3.06569113
118protein demethylation (GO:0006482)3.06012157
119protein dealkylation (GO:0008214)3.06012157
120gamete generation (GO:0007276)3.05581939
121* regulation of chromosome segregation (GO:0051983)3.03882565
122oocyte maturation (GO:0001556)3.03702438
123positive regulation of cell cycle checkpoint (GO:1901978)3.03453463
124DNA biosynthetic process (GO:0071897)3.00882463
125positive regulation of cellular response to oxidative stress (GO:1900409)2.97451747
126positive regulation of response to oxidative stress (GO:1902884)2.97451747
127tooth mineralization (GO:0034505)2.89585076
128embryonic body morphogenesis (GO:0010172)2.88631722
129regulation of transcription from RNA polymerase I promoter (GO:0006356)2.87363004
130cellular process involved in reproduction in multicellular organism (GO:0022412)2.86660864
131mechanosensory behavior (GO:0007638)2.86584832
132negative regulation of meiotic cell cycle (GO:0051447)2.85248908
133proteasome assembly (GO:0043248)2.85195257
134positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.82096482
135cochlea development (GO:0090102)2.75302297
136response to auditory stimulus (GO:0010996)2.70549598
137* nuclear division (GO:0000280)2.69652010
138positive regulation of translational initiation (GO:0045948)2.68906800
139regulation of centrosome duplication (GO:0010824)2.64473105
140left/right axis specification (GO:0070986)2.62400544
141detection of chemical stimulus involved in sensory perception (GO:0050907)2.61948282
142phosphate ion homeostasis (GO:0055062)2.61516692
143trivalent inorganic anion homeostasis (GO:0072506)2.61516692
144regulation of sister chromatid cohesion (GO:0007063)2.61222841
145cell morphogenesis involved in neuron differentiation (GO:0048667)2.56855319
146* organelle fission (GO:0048285)2.56184489
147regulation of T-helper 1 cell differentiation (GO:0045625)2.56160479
148reflex (GO:0060004)2.55312640
149startle response (GO:0001964)2.54497875
150piRNA metabolic process (GO:0034587)11.2382610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.39801796
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.43050961
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.81980473
4IGF1R_20145208_ChIP-Seq_DFB_Human4.64717840
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.36246569
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.83308209
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17897119
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.10150672
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.08787924
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.00349003
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.96399105
12VDR_22108803_ChIP-Seq_LS180_Human2.90312346
13ZNF274_21170338_ChIP-Seq_K562_Hela2.56183473
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.47395639
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36854832
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.26175451
17* ER_23166858_ChIP-Seq_MCF-7_Human2.25954599
18MYCN_18555785_ChIP-Seq_MESCs_Mouse2.25252837
19AR_21909140_ChIP-Seq_LNCAP_Human2.22573085
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21703368
21POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19650011
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15985022
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13532452
24EZH2_22144423_ChIP-Seq_EOC_Human2.13249033
25* RNF2_27304074_Chip-Seq_NSC_Mouse2.11811144
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.11180255
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10846230
28* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.10102295
29* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.10102295
30* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.10102295
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07936525
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01649338
33CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.99530091
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.96804627
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86671393
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78948425
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.78948425
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75049919
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71106153
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71098769
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70617791
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69003781
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68509308
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67604499
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.61079742
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60716167
47SMAD4_21741376_ChIP-Seq_EPCs_Human1.58767213
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57838888
49HOXB7_26014856_ChIP-Seq_BT474_Human1.55337383
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53584132
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.53083777
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53058188
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.52749725
54* FUS_26573619_Chip-Seq_HEK293_Human1.51292453
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51177500
56XRN2_22483619_ChIP-Seq_HELA_Human1.48714830
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47694891
58* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45727702
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44688758
60* STAT3_23295773_ChIP-Seq_U87_Human1.42262140
61TAF15_26573619_Chip-Seq_HEK293_Human1.39083241
62* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38633768
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37894232
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35757692
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35458671
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35436743
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.35052205
68VDR_23849224_ChIP-Seq_CD4+_Human1.34872166
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34774996
70KDM5A_27292631_Chip-Seq_BREAST_Human1.33989609
71TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.33022414
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31487728
73* BCAT_22108803_ChIP-Seq_LS180_Human1.31473996
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29332425
75CBP_20019798_ChIP-Seq_JUKART_Human1.29332425
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29041864
77AR_21572438_ChIP-Seq_LNCaP_Human1.28868192
78GBX2_23144817_ChIP-Seq_PC3_Human1.28497376
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28366529
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.27880028
81HTT_18923047_ChIP-ChIP_STHdh_Human1.27195377
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26671590
83RUNX2_22187159_ChIP-Seq_PCA_Human1.26073080
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25462553
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24113455
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23773490
87* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23181023
88* FOXA1_25329375_ChIP-Seq_VCAP_Human1.23181023
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22589604
90* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21761717
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.21742722
92DCP1A_22483619_ChIP-Seq_HELA_Human1.20360547
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19912014
94TCF4_23295773_ChIP-Seq_U87_Human1.17714859
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17497171
96GABP_19822575_ChIP-Seq_HepG2_Human1.16364070
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16341705
98FOXP3_21729870_ChIP-Seq_TREG_Human1.15994654
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15379668
100* ERA_21632823_ChIP-Seq_H3396_Human1.14994275
101E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14936768
102SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14882086
103TTF2_22483619_ChIP-Seq_HELA_Human1.14025098
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13923405
105* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13861504
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12686841
107EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12524396
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11901027
109GABP_17652178_ChIP-ChIP_JURKAT_Human1.11808140
110* AR_25329375_ChIP-Seq_VCAP_Human1.11719171
111* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11557446
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.10622420
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10150952
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09665593
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.09633312
116TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09026392
117FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08880082
118GATA3_26560356_Chip-Seq_TH1_Human1.08827989
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08821651
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06868392
121NANOG_21062744_ChIP-ChIP_HESCs_Human1.06858732
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.06172327
123ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05805202
124TFEB_21752829_ChIP-Seq_HELA_Human1.04470105
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04140632
126* EWS_26573619_Chip-Seq_HEK293_Human1.04101689
127* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03834149
128THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03005789
129* TCF4_22108803_ChIP-Seq_LS180_Human1.02789442
130* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02333093
131P300_19829295_ChIP-Seq_ESCs_Human1.01437063
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01374491
133* TP53_22573176_ChIP-Seq_HFKS_Human1.01224425
134* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99871881
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97067255
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96306215
137* SMAD4_21799915_ChIP-Seq_A2780_Human0.93550400
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.93335836
139NANOG_19829295_ChIP-Seq_ESCs_Human0.92385384
140SOX2_19829295_ChIP-Seq_ESCs_Human0.92385384
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92167462
142NANOG_18555785_Chip-Seq_ESCs_Mouse0.92117896
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.90122591
144POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89928783
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88982545
146STAT3_18555785_Chip-Seq_ESCs_Mouse0.88699747
147OCT4_20526341_ChIP-Seq_ESCs_Human0.88208675
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88193316
149* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87705494
150* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87006471
151KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86532294
152* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86393657
153* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85198172
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84612545
155FLI1_27457419_Chip-Seq_LIVER_Mouse0.84556583
156* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83038967
157KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82519198
158NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.82012250
159CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81072747
160TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80966970
161ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80561455
162DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79784373
163NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79152323
164ELK1_19687146_ChIP-ChIP_HELA_Human0.78504889
165RUNX1_26923725_Chip-Seq_HPCs_Mouse0.77776132
166* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.77584538
167ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77339178
168* CIITA_25753668_ChIP-Seq_RAJI_Human0.74591695
169E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73675920
170* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.72838514
171KAP1_27257070_Chip-Seq_ESCs_Mouse0.71784732
172* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71002998
173NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.70637237
174TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.69264918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.89722353
2MP0010094_abnormal_chromosome_stability4.49404978
3MP0008057_abnormal_DNA_replication4.42000900
4MP0005410_abnormal_fertilization3.84524810
5MP0003111_abnormal_nucleus_morphology3.70268455
6* MP0002210_abnormal_sex_determination3.69668056
7MP0008058_abnormal_DNA_repair3.66899821
8MP0008995_early_reproductive_senescence3.60944289
9* MP0001929_abnormal_gametogenesis3.59862123
10MP0003693_abnormal_embryo_hatching3.36664716
11MP0003786_premature_aging3.13684084
12MP0004957_abnormal_blastocyst_morpholog3.11505163
13MP0003077_abnormal_cell_cycle3.10393897
14* MP0001145_abnormal_male_reproductive3.05128630
15* MP0003698_abnormal_male_reproductive3.02449806
16MP0008004_abnormal_stomach_pH2.75410351
17* MP0000653_abnormal_sex_gland2.70940388
18MP0005084_abnormal_gallbladder_morpholo2.57456534
19MP0000678_abnormal_parathyroid_gland2.56610959
20MP0002653_abnormal_ependyma_morphology2.38397019
21MP0008007_abnormal_cellular_replicative2.29857740
22MP0010307_abnormal_tumor_latency2.28209563
23MP0003123_paternal_imprinting2.26456062
24MP0008961_abnormal_basal_metabolism2.08011880
25MP0001730_embryonic_growth_arrest2.06234057
26MP0000383_abnormal_hair_follicle1.96603728
27MP0010352_gastrointestinal_tract_polyps1.94796025
28* MP0002161_abnormal_fertility/fecundity1.83994619
29MP0008932_abnormal_embryonic_tissue1.83306101
30MP0000350_abnormal_cell_proliferation1.83057867
31MP0003890_abnormal_embryonic-extraembry1.55346828
32MP0005076_abnormal_cell_differentiation1.53584958
33MP0002084_abnormal_developmental_patter1.48264354
34MP0003121_genomic_imprinting1.48109695
35MP0005380_embryogenesis_phenotype1.47475768
36MP0001672_abnormal_embryogenesis/_devel1.47475768
37MP0002160_abnormal_reproductive_system1.45053064
38MP0002085_abnormal_embryonic_tissue1.43791836
39MP0001119_abnormal_female_reproductive1.43045729
40MP0004197_abnormal_fetal_growth/weight/1.42072946
41MP0001697_abnormal_embryo_size1.40211302
42MP0003718_maternal_effect1.38308083
43MP0005174_abnormal_tail_pigmentation1.37217395
44MP0008260_abnormal_autophagy1.37016379
45MP0005623_abnormal_meninges_morphology1.35789341
46MP0005423_abnormal_somatic_nervous1.28928651
47MP0003787_abnormal_imprinting1.27640512
48MP0003984_embryonic_growth_retardation1.27511129
49MP0010678_abnormal_skin_adnexa1.27069506
50MP0002088_abnormal_embryonic_growth/wei1.21976710
51MP0003943_abnormal_hepatobiliary_system1.21575389
52MP0002086_abnormal_extraembryonic_tissu1.21075768
53MP0002080_prenatal_lethality1.14035235
54MP0000313_abnormal_cell_death1.12589926
55MP0003878_abnormal_ear_physiology1.08931104
56MP0005377_hearing/vestibular/ear_phenot1.08931104
57MP0002736_abnormal_nociception_after1.07342629
58MP0003315_abnormal_perineum_morphology1.05693173
59MP0003699_abnormal_female_reproductive1.04622327
60MP0001293_anophthalmia1.03167770
61MP0009278_abnormal_bone_marrow1.00053834
62MP0003941_abnormal_skin_development0.99593705
63MP0004808_abnormal_hematopoietic_stem0.99106439
64MP0005389_reproductive_system_phenotype0.97798250
65MP0000015_abnormal_ear_pigmentation0.96421711
66MP0003936_abnormal_reproductive_system0.95627293
67MP0002019_abnormal_tumor_incidence0.94500851
68MP0006035_abnormal_mitochondrial_morpho0.93178230
69MP0006276_abnormal_autonomic_nervous0.92435393
70MP0002735_abnormal_chemical_nociception0.91543447
71MP0001968_abnormal_touch/_nociception0.91088127
72MP0005647_abnormal_sex_gland0.89987158
73MP0001915_intracranial_hemorrhage0.84712739
74MP0004233_abnormal_muscle_weight0.83345254
75MP0003119_abnormal_digestive_system0.77096758
76MP0002928_abnormal_bile_duct0.76199075
77MP0001545_abnormal_hematopoietic_system0.72911679
78MP0005397_hematopoietic_system_phenotyp0.72911679
79MP0003937_abnormal_limbs/digits/tail_de0.72821139
80MP0000537_abnormal_urethra_morphology0.72141387
81MP0009703_decreased_birth_body0.71962440
82MP0005621_abnormal_cell_physiology0.71852233
83MP0009672_abnormal_birth_weight0.71570560
84MP0003879_abnormal_hair_cell0.70994303
85MP0000569_abnormal_digit_pigmentation0.70597084
86MP0004133_heterotaxia0.69208910
87MP0005379_endocrine/exocrine_gland_phen0.69012186
88MP0002132_abnormal_respiratory_system0.67747076
89MP0005384_cellular_phenotype0.66789567
90MP0003705_abnormal_hypodermis_morpholog0.66543631
91MP0000371_diluted_coat_color0.66403748
92MP0003646_muscle_fatigue0.66208334
93MP0005551_abnormal_eye_electrophysiolog0.65026040
94MP0003861_abnormal_nervous_system0.64111725
95MP0002697_abnormal_eye_size0.64105344
96MP0005670_abnormal_white_adipose0.63942787
97MP0000470_abnormal_stomach_morphology0.62160764
98MP0005310_abnormal_salivary_gland0.61840002
99MP0003567_abnormal_fetal_cardiomyocyte0.61617981
100MP0002396_abnormal_hematopoietic_system0.61575808
101MP0003880_abnormal_central_pattern0.61492186
102MP0003566_abnormal_cell_adhesion0.61190183
103MP0003183_abnormal_peptide_metabolism0.60334757
104MP0001661_extended_life_span0.59324598
105MP0002184_abnormal_innervation0.59155908
106MP0001849_ear_inflammation0.59038571
107MP0003136_yellow_coat_color0.58872581
108MP0003638_abnormal_response/metabolism_0.58417682
109MP0002909_abnormal_adrenal_gland0.58386060
110MP0002249_abnormal_larynx_morphology0.58073327
111MP0000432_abnormal_head_morphology0.57903224
112MP0005646_abnormal_pituitary_gland0.56401450
113MP0004043_abnormal_pH_regulation0.56028802
114MP0005395_other_phenotype0.55863996
115MP0002092_abnormal_eye_morphology0.54317096
116MP0001984_abnormal_olfaction0.53964553
117MP0000490_abnormal_crypts_of0.53811663
118MP0002254_reproductive_system_inflammat0.52472398
119MP0003115_abnormal_respiratory_system0.52308312
120MP0004742_abnormal_vestibular_system0.51443965
121MP0005023_abnormal_wound_healing0.51297768
122MP0001529_abnormal_vocalization0.51259518
123MP0002108_abnormal_muscle_morphology0.50167346
124MP0000358_abnormal_cell_content/0.48775054
125MP0002095_abnormal_skin_pigmentation0.48628275
126MP0002067_abnormal_sensory_capabilities0.48477096
127MP0004264_abnormal_extraembryonic_tissu0.46741260
128MP0004019_abnormal_vitamin_homeostasis0.46573885
129MP0000703_abnormal_thymus_morphology0.46312474
130MP0002089_abnormal_postnatal_growth/wei0.46249059
131MP0002282_abnormal_trachea_morphology0.46173956
132MP0000427_abnormal_hair_cycle0.46049149
133MP0003806_abnormal_nucleotide_metabolis0.45846088
134MP0004782_abnormal_surfactant_physiolog0.44924316
135MP0002229_neurodegeneration0.44581473
136MP0001919_abnormal_reproductive_system0.44225719
137MP0000647_abnormal_sebaceous_gland0.43012983
138MP0000372_irregular_coat_pigmentation0.42928001
139MP0005266_abnormal_metabolism0.42737710
140MP0002139_abnormal_hepatobiliary_system0.42636986
141MP0004185_abnormal_adipocyte_glucose0.42423368
142MP0009764_decreased_sensitivity_to0.40343746
143MP0002009_preneoplasia0.40280215
144MP0002075_abnormal_coat/hair_pigmentati0.40068181
145MP0003448_altered_tumor_morphology0.40040648
146MP0000631_abnormal_neuroendocrine_gland0.39767247
147MP0002925_abnormal_cardiovascular_devel0.39374678
148MP0009046_muscle_twitch0.39063251
149MP0002111_abnormal_tail_morphology0.38942784
150MP0002102_abnormal_ear_morphology0.38684105
151MP0005448_abnormal_energy_balance0.38557749

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.83174820
2Azoospermia (HP:0000027)5.14625020
3Chromsome breakage (HP:0040012)5.12190551
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.88400851
5Abnormal spermatogenesis (HP:0008669)4.84931745
6Oligodactyly (hands) (HP:0001180)4.82334982
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.56601692
8Absent/shortened dynein arms (HP:0200106)4.56601692
9Spontaneous abortion (HP:0005268)4.33141890
10Abnormality of the lower motor neuron (HP:0002366)4.22523167
11Osteomalacia (HP:0002749)4.20425941
12Degeneration of the lateral corticospinal tracts (HP:0002314)4.19380705
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.19380705
14Gonadotropin excess (HP:0000837)4.10032667
15Ependymoma (HP:0002888)4.00053475
16Impulsivity (HP:0100710)3.80445221
17Abnormal respiratory motile cilium physiology (HP:0012261)3.62446090
18Medulloblastoma (HP:0002885)3.57794447
19Abnormality of chromosome stability (HP:0003220)3.53729842
20Concave nail (HP:0001598)3.51098201
21Horizontal nystagmus (HP:0000666)3.43443113
22Ectopic kidney (HP:0000086)3.29102690
23Shoulder girdle muscle weakness (HP:0003547)3.28295886
24Abnormality of the labia minora (HP:0012880)3.22547842
25Rhinitis (HP:0012384)3.20226749
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.20213431
27Abnormal respiratory epithelium morphology (HP:0012253)3.19255586
28Abnormal respiratory motile cilium morphology (HP:0005938)3.19255586
29Selective tooth agenesis (HP:0001592)3.18955175
30Oligodactyly (HP:0012165)3.14577023
31Meckel diverticulum (HP:0002245)3.13516408
32Abnormality of the astrocytes (HP:0100707)3.13411737
33Astrocytoma (HP:0009592)3.13411737
34Supernumerary spleens (HP:0009799)3.12841683
35Agnosia (HP:0010524)3.06188415
36Abnormality of the ileum (HP:0001549)3.00737548
3711 pairs of ribs (HP:0000878)2.99539072
38Rhabdomyosarcoma (HP:0002859)2.98496408
39Broad distal phalanx of finger (HP:0009836)2.98042540
40Abnormality of the corticospinal tract (HP:0002492)2.97539171
41Male infertility (HP:0003251)2.97157467
42Sparse lateral eyebrow (HP:0005338)2.94457498
43Abnormality of the preputium (HP:0100587)2.88407228
44Infertility (HP:0000789)2.88003131
45Chronic bronchitis (HP:0004469)2.85866024
46Absent thumb (HP:0009777)2.82957551
47Neoplasm of the oral cavity (HP:0100649)2.80377989
48Lip pit (HP:0100267)2.78367624
49Amelogenesis imperfecta (HP:0000705)2.77662030
50Absent radius (HP:0003974)2.77175366
51Abnormal ciliary motility (HP:0012262)2.68883408
52Abnormality of the anterior horn cell (HP:0006802)2.68177199
53Degeneration of anterior horn cells (HP:0002398)2.68177199
54Glioma (HP:0009733)2.64335050
55Upper motor neuron abnormality (HP:0002127)2.59823701
56Papillary thyroid carcinoma (HP:0002895)2.59552988
57Absent forearm bone (HP:0003953)2.59545960
58Aplasia involving forearm bones (HP:0009822)2.59545960
59Scotoma (HP:0000575)2.59103841
60Duplicated collecting system (HP:0000081)2.54068619
61Severe Myopia (HP:0011003)2.53374665
62Birth length less than 3rd percentile (HP:0003561)2.52749465
63Duodenal stenosis (HP:0100867)2.52571277
64Small intestinal stenosis (HP:0012848)2.52571277
65Impaired vibration sensation in the lower limbs (HP:0002166)2.50408204
66Type I transferrin isoform profile (HP:0003642)2.49847118
67Neoplasm of striated muscle (HP:0009728)2.47726300
68Facial hemangioma (HP:0000329)2.47222339
69Abnormality of the dental pulp (HP:0006479)2.46825192
70Amyotrophic lateral sclerosis (HP:0007354)2.45784418
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.45197598
72Abnormal protein N-linked glycosylation (HP:0012347)2.45197598
73Abnormal protein glycosylation (HP:0012346)2.45197598
74Abnormal glycosylation (HP:0012345)2.45197598
75Biliary tract neoplasm (HP:0100574)2.43235790
76Colon cancer (HP:0003003)2.42901124
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42771253
78Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.42702683
79Volvulus (HP:0002580)2.42625557
80Abnormality of the renal medulla (HP:0100957)2.42370869
81Heterotopia (HP:0002282)2.41465095
82Abnormality of the carotid arteries (HP:0005344)2.40425684
83Rimmed vacuoles (HP:0003805)2.39347769
84Abnormal lung lobation (HP:0002101)2.39329605
85Nephronophthisis (HP:0000090)2.39017140
86Hypoplastic iliac wings (HP:0002866)2.37632376
87Capillary hemangiomas (HP:0005306)2.36013961
88Breast hypoplasia (HP:0003187)2.33653094
89Carpal bone hypoplasia (HP:0001498)2.32944266
90Sloping forehead (HP:0000340)2.32782644
91Shawl scrotum (HP:0000049)2.32001001
92Generalized hypopigmentation of hair (HP:0011358)2.28617324
93Short nail (HP:0001799)2.27656159
94Urinary bladder sphincter dysfunction (HP:0002839)2.27596305
95Missing ribs (HP:0000921)2.26376045
96Nasal polyposis (HP:0100582)2.25543701
97Fair hair (HP:0002286)2.23169076
98Nephroblastoma (Wilms tumor) (HP:0002667)2.21664989
99Patellar aplasia (HP:0006443)2.16178261
100Abnormality of the phalanges of the 5th finger (HP:0004213)2.12510082
101Atonic seizures (HP:0010819)2.12274227
102Prominent nose (HP:0000448)2.11431866
103Increased nuchal translucency (HP:0010880)2.10874243
104Short thumb (HP:0009778)2.08975287
105Aplasia/Hypoplasia of the earlobes (HP:0009906)2.06121418
106Abnormality of chromosome segregation (HP:0002916)2.04627566
107Abnormality of the renal collecting system (HP:0004742)2.04565189
108Sandal gap (HP:0001852)2.04542069
109Abnormality of DNA repair (HP:0003254)2.01987758
110Cafe-au-lait spot (HP:0000957)2.01984073
111Urethral obstruction (HP:0000796)2.01233816
112Abnormality of calcium-phosphate metabolism (HP:0100530)2.01192478
113Basal cell carcinoma (HP:0002671)2.00270164
114Clubbing of toes (HP:0100760)1.99970580
115Embryonal renal neoplasm (HP:0011794)1.99962138
116Fibular hypoplasia (HP:0003038)1.98825091
117Abnormality of the duodenum (HP:0002246)1.98103313
118Proximal placement of thumb (HP:0009623)1.97585536
119Myelodysplasia (HP:0002863)1.97471905
120Abnormality of renal resorption (HP:0011038)1.97059020
121Hyperpituitarism (HP:0010514)1.96739352
122Truncal obesity (HP:0001956)1.96328995
123Aplasia/hypoplasia of the humerus (HP:0006507)1.94966621
124Menstrual irregularities (HP:0000858)1.94954101
125Disinhibition (HP:0000734)1.94909292
126Reticulocytopenia (HP:0001896)1.94880649
127Hand muscle atrophy (HP:0009130)1.94097161
128Thick eyebrow (HP:0000574)1.93472612
129Genetic anticipation (HP:0003743)1.92854776
130Tubulointerstitial nephritis (HP:0001970)1.92310967
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92099088
132Aplasia/Hypoplasia of the patella (HP:0006498)1.90685221
133Facial cleft (HP:0002006)1.90423723
134Urinary urgency (HP:0000012)1.90359741
135Metaphyseal cupping (HP:0003021)1.90351725
136Deviation of the thumb (HP:0009603)1.89399251
137Abnormality of dental color (HP:0011073)1.89052088
138Microglossia (HP:0000171)1.88287102
139Gaze-evoked nystagmus (HP:0000640)1.87819371
140Short humerus (HP:0005792)1.86795945
141Hyperkalemia (HP:0002153)1.86418830
142Abnormality of midbrain morphology (HP:0002418)1.85832323
143Molar tooth sign on MRI (HP:0002419)1.85832323
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.85535773
145Severe visual impairment (HP:0001141)1.85443635
146Supernumerary ribs (HP:0005815)1.85000995
147Abdominal situs inversus (HP:0003363)1.83741783
148Abnormality of abdominal situs (HP:0011620)1.83741783
149Impaired vibratory sensation (HP:0002495)1.83649859
150Spinal muscular atrophy (HP:0007269)1.82095771
151Aplasia/Hypoplasia of the sternum (HP:0006714)1.81247518
152Non-midline cleft lip (HP:0100335)1.81220430
153Bronchiectasis (HP:0002110)1.81201746
154Astigmatism (HP:0000483)1.80894785
155Abnormality of the fingertips (HP:0001211)1.78418115
156Polyuria (HP:0000103)1.78232275
157Malignant gastrointestinal tract tumors (HP:0006749)1.78098476
158Gastrointestinal carcinoma (HP:0002672)1.78098476
159Widely spaced teeth (HP:0000687)1.77403655
160Bony spicule pigmentary retinopathy (HP:0007737)1.74727867
161Attenuation of retinal blood vessels (HP:0007843)1.74087230
162Highly arched eyebrow (HP:0002553)1.71213088
163Tubulointerstitial abnormality (HP:0001969)1.69541536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.15575706
2CDC75.04602045
3PDK44.04246884
4PDK34.04246884
5NTRK23.31053466
6WEE13.28434800
7NEK23.27168497
8ACVR1B3.08677883
9CDK192.92692552
10TTK2.77429948
11PDK22.70862625
12BRD42.55894281
13MUSK2.47428564
14PNCK2.25110515
15CSF1R2.24719618
16PLK42.08381283
17FRK2.06604397
18ICK2.03923836
19ATR1.93700491
20* PLK11.82019439
21CHEK21.70378474
22PRKD31.68863500
23CHEK11.65952458
24CDK71.64532577
25OXSR11.50816432
26BUB11.48753090
27SRPK11.47303504
28ATM1.45925461
29STK38L1.45391144
30BMX1.35370197
31MST41.34655269
32EPHA21.34106908
33CASK1.34088546
34PASK1.32821877
35STK31.30857868
36NEK11.30420489
37BRSK21.24471894
38CDK41.23082175
39SIK11.22977223
40NEK61.19455295
41FGR1.17586516
42PLK31.13177055
43AURKB1.11372972
44TESK11.10345852
45CAMK1D1.05233854
46MTOR1.04316198
47TYRO31.02673193
48STK41.02330996
49CDK91.02096603
50CDK21.01175768
51RPS6KB20.99213961
52NEK90.98791154
53DYRK30.97973748
54MKNK20.96893486
55EIF2AK10.95048032
56MAP3K90.94288257
57CCNB10.93947013
58TSSK60.92563246
59MELK0.88267789
60INSRR0.85099486
61EIF2AK20.82677512
62MAP3K130.81161165
63EEF2K0.78987077
64WNK30.78906273
65LATS10.78694565
66MAP3K50.78377615
67* CDK10.78087312
68AURKA0.77324838
69SCYL20.76683480
70MET0.71248325
71CSNK1D0.70020474
72PDGFRB0.69709669
73PBK0.67634704
74RET0.66496008
75MAP4K20.66478744
76IRAK30.66365935
77MKNK10.65445860
78MAP3K40.62552957
79MST1R0.61830271
80PINK10.61698741
81KSR20.60657077
82PRKDC0.60317413
83PTK2B0.59840827
84CAMK1G0.59604164
85MAP3K80.58295485
86TNK20.57730557
87STK100.57161574
88BRSK10.55232599
89MAP3K20.54591477
90CSNK2A20.53810727
91AKT30.53522418
92ZAK0.53339672
93CDK60.53076077
94ROCK10.51832810
95PIM10.51582210
96ALK0.50234681
97PRKAA10.49604993
98EGFR0.49485179
99CSNK1E0.48929278
100VRK10.48312756
101GSK3B0.47704702
102STK160.47465313
103MAP3K100.47358705
104STK380.46949516
105PDK10.46537518
106KSR10.45317585
107PAK40.44565888
108MAPK140.44223241
109IKBKB0.42863448
110BMPR1B0.42635320
111MAP3K60.42623012
112LATS20.42392664
113WNK10.41695976
114TGFBR10.40486709
115RPS6KA40.40127849
116CAMK10.40069691
117PKN10.39259172
118TLK10.39216317
119SGK10.38621360
120RPS6KB10.36756709
121CSNK2A10.35951026
122PDPK10.35946371
123MAPK10.35736976
124CHUK0.34600223
125BRAF0.34506283
126AKT10.33385192
127STK240.32866076
128MAP4K10.30908291
129MAPKAPK30.29829666
130BLK0.29288705
131MARK30.28328436
132MAPK80.27988579
133MAPK100.26641674
134ADRBK10.26621388
135PRKCI0.26425666
136RPS6KA50.26398825
137PAK10.25582490
138CDK30.25089649
139FLT30.24949368
140EIF2AK30.24281059
141ADRBK20.23225094
142RPS6KA10.22515245
143MAP2K20.21538110
144PRKACB0.21432144
145CDC42BPA0.21267105
146CDK80.20661820
147PLK20.20211739

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.44998769
2Mismatch repair_Homo sapiens_hsa034304.18101886
3DNA replication_Homo sapiens_hsa030303.94905848
4Basal transcription factors_Homo sapiens_hsa030223.85649103
5RNA transport_Homo sapiens_hsa030133.63288610
6Fanconi anemia pathway_Homo sapiens_hsa034603.62483704
7Homologous recombination_Homo sapiens_hsa034403.47347713
8Sulfur relay system_Homo sapiens_hsa041223.31399089
9Cell cycle_Homo sapiens_hsa041103.11635265
10Spliceosome_Homo sapiens_hsa030402.81716309
11Olfactory transduction_Homo sapiens_hsa047402.79107613
12mRNA surveillance pathway_Homo sapiens_hsa030152.78061739
13Nucleotide excision repair_Homo sapiens_hsa034202.75542594
14Non-homologous end-joining_Homo sapiens_hsa034502.57522582
15One carbon pool by folate_Homo sapiens_hsa006702.48911213
16Base excision repair_Homo sapiens_hsa034102.45904069
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33601252
18RNA polymerase_Homo sapiens_hsa030202.31226845
19RNA degradation_Homo sapiens_hsa030182.21949377
20Ovarian steroidogenesis_Homo sapiens_hsa049132.16854081
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.05203594
22Selenocompound metabolism_Homo sapiens_hsa004501.91735309
23Regulation of autophagy_Homo sapiens_hsa041401.88622314
24Oocyte meiosis_Homo sapiens_hsa041141.86555502
25Pyrimidine metabolism_Homo sapiens_hsa002401.57793929
26Dorso-ventral axis formation_Homo sapiens_hsa043201.55709166
27p53 signaling pathway_Homo sapiens_hsa041151.52458646
28Proteasome_Homo sapiens_hsa030501.50697339
29Circadian rhythm_Homo sapiens_hsa047101.49636399
30Taste transduction_Homo sapiens_hsa047421.36154108
31Propanoate metabolism_Homo sapiens_hsa006401.24444149
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24031923
33Epstein-Barr virus infection_Homo sapiens_hsa051691.19408083
34Herpes simplex infection_Homo sapiens_hsa051681.19181117
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16895454
36ABC transporters_Homo sapiens_hsa020101.09157278
37Antigen processing and presentation_Homo sapiens_hsa046121.06923761
38Systemic lupus erythematosus_Homo sapiens_hsa053221.03556795
39Viral carcinogenesis_Homo sapiens_hsa052031.03195295
40Caffeine metabolism_Homo sapiens_hsa002321.01780981
41Purine metabolism_Homo sapiens_hsa002301.01053878
42Lysine degradation_Homo sapiens_hsa003100.99677293
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98469006
44Type II diabetes mellitus_Homo sapiens_hsa049300.96443857
45TGF-beta signaling pathway_Homo sapiens_hsa043500.94544853
46Vitamin B6 metabolism_Homo sapiens_hsa007500.92652586
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92422864
48Calcium signaling pathway_Homo sapiens_hsa040200.91176499
49Notch signaling pathway_Homo sapiens_hsa043300.90312355
50N-Glycan biosynthesis_Homo sapiens_hsa005100.86361051
51HTLV-I infection_Homo sapiens_hsa051660.85238439
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.83033290
53MicroRNAs in cancer_Homo sapiens_hsa052060.78672204
54Pentose phosphate pathway_Homo sapiens_hsa000300.77723929
55Linoleic acid metabolism_Homo sapiens_hsa005910.73065460
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72779820
57Adherens junction_Homo sapiens_hsa045200.71740095
58Synaptic vesicle cycle_Homo sapiens_hsa047210.70930538
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.69758901
60Collecting duct acid secretion_Homo sapiens_hsa049660.66818593
61Biosynthesis of amino acids_Homo sapiens_hsa012300.65561861
62Sulfur metabolism_Homo sapiens_hsa009200.63662042
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63237107
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.63121637
65Hippo signaling pathway_Homo sapiens_hsa043900.62772225
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62294936
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61194009
68Influenza A_Homo sapiens_hsa051640.57330414
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55763445
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55550781
71Pyruvate metabolism_Homo sapiens_hsa006200.53424724
72beta-Alanine metabolism_Homo sapiens_hsa004100.53303897
73Thyroid cancer_Homo sapiens_hsa052160.52988264
74Fatty acid biosynthesis_Homo sapiens_hsa000610.51676324
75Basal cell carcinoma_Homo sapiens_hsa052170.50826135
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50478904
77Small cell lung cancer_Homo sapiens_hsa052220.49547382
78Pancreatic secretion_Homo sapiens_hsa049720.49389363
79Glucagon signaling pathway_Homo sapiens_hsa049220.48668484
80Colorectal cancer_Homo sapiens_hsa052100.47054791
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46840266
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43308912
83Phototransduction_Homo sapiens_hsa047440.43024848
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42835378
85Tight junction_Homo sapiens_hsa045300.42399494
86Oxytocin signaling pathway_Homo sapiens_hsa049210.42329784
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.39177397
88Hedgehog signaling pathway_Homo sapiens_hsa043400.39134790
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38627532
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.38133830
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37955020
92Gap junction_Homo sapiens_hsa045400.37871361
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37838584
94Circadian entrainment_Homo sapiens_hsa047130.37828696
95Fat digestion and absorption_Homo sapiens_hsa049750.37730993
96ErbB signaling pathway_Homo sapiens_hsa040120.37581178
97Ribosome_Homo sapiens_hsa030100.36587708
98mTOR signaling pathway_Homo sapiens_hsa041500.35725086
99Glutamatergic synapse_Homo sapiens_hsa047240.35516334
100Salivary secretion_Homo sapiens_hsa049700.35205888
101Prostate cancer_Homo sapiens_hsa052150.35159265
102Huntingtons disease_Homo sapiens_hsa050160.33973413
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33956183
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.32963729
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32562590
106Bile secretion_Homo sapiens_hsa049760.32276430
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31590277
108Pathways in cancer_Homo sapiens_hsa052000.31368643
109Alcoholism_Homo sapiens_hsa050340.29964350
110Gastric acid secretion_Homo sapiens_hsa049710.29023434
111Glycerolipid metabolism_Homo sapiens_hsa005610.28890788
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28477867
113MAPK signaling pathway_Homo sapiens_hsa040100.28211731
114Wnt signaling pathway_Homo sapiens_hsa043100.27687634
115Legionellosis_Homo sapiens_hsa051340.27444550
116Choline metabolism in cancer_Homo sapiens_hsa052310.27387490
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26012069
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25212457
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.25158965
120Chemokine signaling pathway_Homo sapiens_hsa040620.24745213
121Prolactin signaling pathway_Homo sapiens_hsa049170.22667910
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.21349917
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20723850
124FoxO signaling pathway_Homo sapiens_hsa040680.20235805
125Retinol metabolism_Homo sapiens_hsa008300.19928530
126HIF-1 signaling pathway_Homo sapiens_hsa040660.19615277
127Glutathione metabolism_Homo sapiens_hsa004800.18070996
128Inositol phosphate metabolism_Homo sapiens_hsa005620.17897935
129Apoptosis_Homo sapiens_hsa042100.16914401
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.14944140
131Carbon metabolism_Homo sapiens_hsa012000.14728000
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13666072
133Fructose and mannose metabolism_Homo sapiens_hsa000510.13390916
134Arachidonic acid metabolism_Homo sapiens_hsa005900.12267719
135Pancreatic cancer_Homo sapiens_hsa052120.10773538
136Ether lipid metabolism_Homo sapiens_hsa005650.10514918
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09113057
138AMPK signaling pathway_Homo sapiens_hsa041520.07626374
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07185476
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04930294
141Hepatitis B_Homo sapiens_hsa051610.03415374
142Measles_Homo sapiens_hsa051620.01726728
143Toxoplasmosis_Homo sapiens_hsa051450.00448073
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.00446026
145Viral myocarditis_Homo sapiens_hsa05416-0.0195963
146Estrogen signaling pathway_Homo sapiens_hsa04915-0.0153858
147Endometrial cancer_Homo sapiens_hsa05213-0.0106150
148Glycine, serine and threonine metabolism_Homo sapiens_hsa00260-0.0030452

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