TEX15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* synaptonemal complex assembly (GO:0007130)8.74280233
2regulation of meiosis I (GO:0060631)8.48863458
3* synaptonemal complex organization (GO:0070193)8.22788968
4* male meiosis (GO:0007140)8.04583089
5regulation of centriole replication (GO:0046599)6.52787471
6centriole replication (GO:0007099)6.41782851
7regulation of chromatin binding (GO:0035561)6.35628773
8snRNA transcription (GO:0009301)6.25854012
9gene silencing by RNA (GO:0031047)6.05915722
10* chromosome organization involved in meiosis (GO:0070192)5.99221872
11DNA alkylation (GO:0006305)5.91967174
12DNA methylation (GO:0006306)5.91967174
13dosage compensation (GO:0007549)5.85608868
14negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 5.82872081
15* meiotic nuclear division (GO:0007126)5.69138950
16positive regulation of meiosis (GO:0045836)5.25381799
17regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 5.12269950
18male meiosis I (GO:0007141)4.94620261
19DNA replication checkpoint (GO:0000076)4.88669548
20positive regulation of meiotic cell cycle (GO:0051446)4.87981502
21negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)4.83079989
22protein localization to kinetochore (GO:0034501)4.74142068
23CENP-A containing nucleosome assembly (GO:0034080)4.69938250
24chromatin remodeling at centromere (GO:0031055)4.68522497
25DNA methylation or demethylation (GO:0044728)4.63131562
26centriole assembly (GO:0098534)4.62869801
27histone exchange (GO:0043486)4.53626190
28oogenesis (GO:0048477)4.40829075
29kinetochore organization (GO:0051383)4.39297213
30gene silencing (GO:0016458)4.30271492
31DNA strand elongation involved in DNA replication (GO:0006271)4.27960913
32nuclear pore organization (GO:0006999)4.27042462
33* meiotic cell cycle process (GO:1903046)4.23373465
34negative regulation of transcription regulatory region DNA binding (GO:2000678)4.22586572
35mitotic sister chromatid segregation (GO:0000070)4.19558118
36sequestering of actin monomers (GO:0042989)4.14231535
37sister chromatid segregation (GO:0000819)4.14127724
38nuclear pore complex assembly (GO:0051292)4.13468260
39protein localization to chromosome, centromeric region (GO:0071459)4.13354066
40microtubule polymerization or depolymerization (GO:0031109)4.10892789
41DNA strand elongation (GO:0022616)4.09155422
42pore complex assembly (GO:0046931)4.07260938
43meiosis I (GO:0007127)4.05062759
44regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)4.01869431
45reciprocal meiotic recombination (GO:0007131)4.01019917
46reciprocal DNA recombination (GO:0035825)4.01019917
47mitotic metaphase plate congression (GO:0007080)3.98953307
48eyelid development in camera-type eye (GO:0061029)3.97540834
49metaphase plate congression (GO:0051310)3.96413118
50histone H3-K9 methylation (GO:0051567)3.93146529
51DNA replication initiation (GO:0006270)3.92838599
52mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.92516148
53positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.92516148
54attachment of spindle microtubules to kinetochore (GO:0008608)3.92035317
55olfactory bulb development (GO:0021772)3.90707459
56DNA replication-independent nucleosome assembly (GO:0006336)3.89707431
57DNA replication-independent nucleosome organization (GO:0034724)3.89707431
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.86411789
59histone H4-K12 acetylation (GO:0043983)3.81738973
60meiotic chromosome segregation (GO:0045132)3.80868117
61kinetochore assembly (GO:0051382)3.80791899
62mitotic nuclear envelope disassembly (GO:0007077)3.80125708
63negative regulation of chromosome segregation (GO:0051985)3.78960659
64sister chromatid cohesion (GO:0007062)3.76836751
65DNA replication-dependent nucleosome organization (GO:0034723)3.76443431
66DNA replication-dependent nucleosome assembly (GO:0006335)3.76443431
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76436170
68negative regulation of mitotic sister chromatid separation (GO:2000816)3.75720426
69negative regulation of sister chromatid segregation (GO:0033046)3.75720426
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.75720426
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.75720426
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.75720426
73telomere maintenance via semi-conservative replication (GO:0032201)3.75708082
74mitotic sister chromatid cohesion (GO:0007064)3.74907695
75positive regulation of DNA-templated transcription, elongation (GO:0032786)3.74426302
76spindle checkpoint (GO:0031577)3.73366113
77DNA synthesis involved in DNA repair (GO:0000731)3.69223871
78DNA unwinding involved in DNA replication (GO:0006268)3.62515090
79regulation of chromosome segregation (GO:0051983)3.60616230
80DNA modification (GO:0006304)3.59473975
81mitotic spindle checkpoint (GO:0071174)3.59056821
82regulation of hippo signaling (GO:0035330)3.58803052
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.56444388
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.56444388
85chromosome condensation (GO:0030261)3.55004264
86meiotic cell cycle (GO:0051321)3.54836909
87DNA packaging (GO:0006323)3.54826855
88membrane disassembly (GO:0030397)3.54492787
89nuclear envelope disassembly (GO:0051081)3.54492787
90oocyte development (GO:0048599)3.53873759
91regulation of DNA endoreduplication (GO:0032875)3.52668178
92regulation of sister chromatid segregation (GO:0033045)3.52370660
93regulation of mitotic sister chromatid separation (GO:0010965)3.52370660
94regulation of mitotic sister chromatid segregation (GO:0033047)3.52370660
95mitotic spindle assembly checkpoint (GO:0007094)3.48707162
96negative regulation of meiosis (GO:0045835)3.48362145
97negative regulation of signal transduction by p53 class mediator (GO:1901797)3.47751614
98DNA double-strand break processing (GO:0000729)3.46777537
99spindle assembly checkpoint (GO:0071173)3.45748259
100regulation of RNA export from nucleus (GO:0046831)3.45383066
101positive regulation of translational initiation (GO:0045948)3.43587075
102somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42689186
103somatic hypermutation of immunoglobulin genes (GO:0016446)3.42689186
104regulation of centrosome duplication (GO:0010824)3.42356826
105mitotic recombination (GO:0006312)3.40489978
106receptor guanylyl cyclase signaling pathway (GO:0007168)3.39836250
107negative regulation of histone modification (GO:0031057)3.36631693
108female gamete generation (GO:0007292)3.36160672
109nucleosome disassembly (GO:0006337)3.34409557
110protein-DNA complex disassembly (GO:0032986)3.34409557
111regulation of mitotic spindle checkpoint (GO:1903504)3.33331405
112regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33331405
113replication fork processing (GO:0031297)3.32794476
114sex differentiation (GO:0007548)3.32615835
115germ cell development (GO:0007281)3.32207562
116telomere maintenance via recombination (GO:0000722)3.31173779
117microtubule nucleation (GO:0007020)3.28019896
118non-recombinational repair (GO:0000726)3.26326413
119double-strand break repair via nonhomologous end joining (GO:0006303)3.26326413
120synapsis (GO:0007129)3.26244601
121regulation of histone H3-K9 methylation (GO:0051570)3.26143147
122positive regulation of cell cycle checkpoint (GO:1901978)3.23904246
123fusion of sperm to egg plasma membrane (GO:0007342)3.23011962
124establishment of chromosome localization (GO:0051303)3.22693970
125histone H3-K9 modification (GO:0061647)3.21580165
126chromosome segregation (GO:0007059)3.19386332
127regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19219644
128positive regulation of chromosome segregation (GO:0051984)3.17745208
129microtubule depolymerization (GO:0007019)3.17233198
130mitotic G2/M transition checkpoint (GO:0044818)3.17105888
131* protein localization to chromosome (GO:0034502)3.16808337
132regulation of centrosome cycle (GO:0046605)3.16385375
133negative regulation of DNA recombination (GO:0045910)3.15546401
134negative regulation of mitosis (GO:0045839)3.14123377
135regulation of cilium movement (GO:0003352)3.11790732
136purine nucleobase biosynthetic process (GO:0009113)3.11042208
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10833073
138ovulation cycle (GO:0042698)3.09594347
139* male gamete generation (GO:0048232)3.08852356
140* spermatogenesis (GO:0007283)3.08773604
141nucleotide-excision repair, DNA gap filling (GO:0006297)3.08753368
142germ cell migration (GO:0008354)3.07292449
143negative regulation of chromatin modification (GO:1903309)3.06338873
144mitotic chromosome condensation (GO:0007076)3.05116275
145histone H4-K8 acetylation (GO:0043982)3.04240714
146histone H4-K5 acetylation (GO:0043981)3.04240714
147protein K6-linked ubiquitination (GO:0085020)3.02194885
148regulation of meiosis (GO:0040020)3.01234797
149regulation of DNA-templated transcription, elongation (GO:0032784)3.00487093
150chromatin assembly or disassembly (GO:0006333)3.00451384
151spermatid development (GO:0007286)3.00393987
152heterochromatin organization (GO:0070828)3.00150347
153IMP biosynthetic process (GO:0006188)3.00128288
154regulation of gene expression, epigenetic (GO:0040029)2.99353228
155regulation of protein polyubiquitination (GO:1902914)2.98668641
156inner cell mass cell proliferation (GO:0001833)2.98218937
157ATP-dependent chromatin remodeling (GO:0043044)2.97303263
158histone H2A acetylation (GO:0043968)2.95657304
159glial cell proliferation (GO:0014009)2.94738415
160resolution of meiotic recombination intermediates (GO:0000712)2.93181918
161negative regulation of histone methylation (GO:0031061)2.92670141
162negative regulation of DNA repair (GO:0045738)2.91818098
163positive regulation of male gonad development (GO:2000020)2.91454970
164* gamete generation (GO:0007276)2.90576071
165positive regulation of mitochondrial membrane permeability (GO:0035794)2.87736474
166male sex determination (GO:0030238)2.86808629
167piRNA metabolic process (GO:0034587)13.1036106
168DNA methylation involved in gamete generation (GO:0043046)10.9616988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse6.04048002
2E2F7_22180533_ChIP-Seq_HELA_Human5.63920332
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.31133212
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.33390396
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.89456315
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.36625263
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.23135474
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.10667268
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05899685
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.89479383
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87397079
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.86908244
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.84482421
14EZH2_22144423_ChIP-Seq_EOC_Human2.81158051
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57695407
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50545423
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.35838663
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29619041
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.21085176
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.20261199
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11689003
22RUNX1_26923725_Chip-Seq_HPCs_Mouse2.05356741
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.00984410
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00733318
25EWS_26573619_Chip-Seq_HEK293_Human1.93930210
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86488942
27ELK1_19687146_ChIP-ChIP_HELA_Human1.81705979
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81369921
29RNF2_27304074_Chip-Seq_NSC_Mouse1.80153253
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77662301
31IGF1R_20145208_ChIP-Seq_DFB_Human1.63354360
32MYC_18940864_ChIP-ChIP_HL60_Human1.58566026
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56341584
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54333532
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.50503230
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50006229
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49822323
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.49805981
39TTF2_22483619_ChIP-Seq_HELA_Human1.49573361
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48698312
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.47484208
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.47165180
43FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44662772
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43994017
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43994017
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43994017
47KDM5A_27292631_Chip-Seq_BREAST_Human1.43983989
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43350984
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43279254
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42997007
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41825444
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40103293
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40004113
54TAF15_26573619_Chip-Seq_HEK293_Human1.38383302
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34747294
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29245803
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28815011
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28554334
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24857882
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.23065466
61XRN2_22483619_ChIP-Seq_HELA_Human1.20673423
62* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20493959
63* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20201020
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18179598
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.16419350
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15802447
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14254870
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14228827
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13591901
70* GATA3_21867929_ChIP-Seq_TH1_Mouse1.11628277
71SOX9_26525672_Chip-Seq_HEART_Mouse1.11498954
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10575153
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08927423
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07563600
75DCP1A_22483619_ChIP-Seq_HELA_Human1.07393741
76ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07192750
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06443432
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05519054
79P300_19829295_ChIP-Seq_ESCs_Human1.04787376
80WDR5_24793694_ChIP-Seq_LNCAP_Human1.04254894
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.04083674
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03776585
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.03209483
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00437206
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99982948
86ZNF274_21170338_ChIP-Seq_K562_Hela0.99634539
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98971194
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98789305
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98154884
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97769937
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96430939
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96080666
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95998683
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95505981
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94908729
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94700114
97GF1_26923725_Chip-Seq_HPCs_Mouse0.93530621
98POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93425408
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92943116
100STAT3_18555785_ChIP-Seq_MESCs_Mouse0.92453984
101GABP_19822575_ChIP-Seq_HepG2_Human0.92435785
102TCF4_23295773_ChIP-Seq_U87_Human0.91383894
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90795137
104CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89495546
105AR_21909140_ChIP-Seq_LNCAP_Human0.88629532
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88398511
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87097308
108IRF1_19129219_ChIP-ChIP_H3396_Human0.87071397
109AHR_22903824_ChIP-Seq_MCF-7_Human0.86041032
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85798787
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85789159
112ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85550447
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85146950
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84811728
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84550699
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83856811
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83449471
118OCT4_19829295_ChIP-Seq_ESCs_Human0.83211583
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.83045592
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82722701
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82086769
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81933461
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81595103
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81233578
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80574332
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.80302679
127* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80212262
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80152307
129FUS_26573619_Chip-Seq_HEK293_Human0.79930384
130* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79291690
131* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79291690
132FOXP3_21729870_ChIP-Seq_TREG_Human0.77758957
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77578932
134SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77405915
135MYC_18555785_ChIP-Seq_MESCs_Mouse0.76980018
136STAT3_23295773_ChIP-Seq_U87_Human0.76578794
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76430195
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.76278126
139VDR_23849224_ChIP-Seq_CD4+_Human0.76005873
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.75690188
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75320999
142EST1_17652178_ChIP-ChIP_JURKAT_Human0.73995046
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73900866
144CIITA_25753668_ChIP-Seq_RAJI_Human0.73606813
145VDR_22108803_ChIP-Seq_LS180_Human0.73412913
146GF1B_26923725_Chip-Seq_HPCs_Mouse0.72839161
147E2F1_17053090_ChIP-ChIP_MCF-7_Human0.72776322
148NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.70711880
149NFYB_21822215_ChIP-Seq_K562_Human0.70039219
150JUN_21703547_ChIP-Seq_K562_Human0.70010914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.88225799
2MP0008995_early_reproductive_senescence4.79000461
3MP0008789_abnormal_olfactory_epithelium3.87154444
4MP0005499_abnormal_olfactory_system3.29656248
5MP0005394_taste/olfaction_phenotype3.29656248
6* MP0002210_abnormal_sex_determination3.25661997
7MP0003121_genomic_imprinting3.18874959
8MP0003718_maternal_effect3.09448410
9* MP0001929_abnormal_gametogenesis2.69516961
10MP0003786_premature_aging2.56365602
11* MP0001145_abnormal_male_reproductive2.52416223
12MP0006292_abnormal_olfactory_placode2.46436346
13MP0000566_synostosis2.46105812
14MP0003123_paternal_imprinting2.36022513
15* MP0003698_abnormal_male_reproductive2.34219929
16* MP0000653_abnormal_sex_gland2.32464328
17MP0010094_abnormal_chromosome_stability2.05139630
18MP0003941_abnormal_skin_development2.04697197
19MP0008877_abnormal_DNA_methylation10.5974012
20MP0001293_anophthalmia1.93111734
21MP0005623_abnormal_meninges_morphology1.92785409
22MP0003136_yellow_coat_color1.90621765
23MP0002160_abnormal_reproductive_system1.88298704
24MP0005410_abnormal_fertilization1.86289412
25* MP0008058_abnormal_DNA_repair1.78439193
26MP0003693_abnormal_embryo_hatching1.69090520
27MP0009697_abnormal_copulation1.66241952
28MP0002233_abnormal_nose_morphology1.61085125
29MP0000372_irregular_coat_pigmentation1.58620351
30MP0002938_white_spotting1.50898837
31MP0001119_abnormal_female_reproductive1.47318927
32MP0003878_abnormal_ear_physiology1.46587474
33MP0005377_hearing/vestibular/ear_phenot1.46587474
34MP0005187_abnormal_penis_morphology1.44302444
35MP0005645_abnormal_hypothalamus_physiol1.41074960
36MP0003567_abnormal_fetal_cardiomyocyte1.39715591
37* MP0002161_abnormal_fertility/fecundity1.38950672
38MP0008057_abnormal_DNA_replication1.32692768
39MP0003077_abnormal_cell_cycle1.32251063
40MP0003119_abnormal_digestive_system1.30466777
41MP0000579_abnormal_nail_morphology1.28150821
42MP0008007_abnormal_cellular_replicative1.27048557
43MP0003111_abnormal_nucleus_morphology1.24606354
44MP0000427_abnormal_hair_cycle1.20933196
45MP0002102_abnormal_ear_morphology1.17044737
46MP0009672_abnormal_birth_weight1.14453960
47MP0001188_hyperpigmentation1.14358503
48MP0009703_decreased_birth_body1.12616539
49MP0002234_abnormal_pharynx_morphology1.12606956
50MP0005389_reproductive_system_phenotype1.11825620
51MP0001730_embryonic_growth_arrest1.11441238
52MP0001346_abnormal_lacrimal_gland1.10620471
53MP0004957_abnormal_blastocyst_morpholog1.08191696
54MP0000428_abnormal_craniofacial_morphol1.07398427
55MP0004134_abnormal_chest_morphology1.06667799
56MP0004808_abnormal_hematopoietic_stem1.05100194
57MP0005395_other_phenotype1.04068054
58MP0003315_abnormal_perineum_morphology1.03703036
59MP0005647_abnormal_sex_gland1.02788437
60MP0010352_gastrointestinal_tract_polyps1.02572812
61MP0003861_abnormal_nervous_system1.01366277
62MP0003890_abnormal_embryonic-extraembry1.01092233
63MP0000350_abnormal_cell_proliferation1.00315312
64MP0000537_abnormal_urethra_morphology0.98602331
65MP0000383_abnormal_hair_follicle0.97867045
66MP0005171_absent_coat_pigmentation0.94808172
67MP0002084_abnormal_developmental_patter0.94251494
68MP0000647_abnormal_sebaceous_gland0.93845757
69MP0002249_abnormal_larynx_morphology0.92607520
70MP0002085_abnormal_embryonic_tissue0.90939756
71MP0003937_abnormal_limbs/digits/tail_de0.88590523
72MP0006072_abnormal_retinal_apoptosis0.88390966
73MP0003938_abnormal_ear_development0.86997731
74MP0002092_abnormal_eye_morphology0.86290875
75MP0003755_abnormal_palate_morphology0.86127238
76MP0010030_abnormal_orbit_morphology0.85274457
77MP0002111_abnormal_tail_morphology0.84538062
78MP0001672_abnormal_embryogenesis/_devel0.84300518
79MP0005380_embryogenesis_phenotype0.84300518
80MP0001299_abnormal_eye_distance/0.82640839
81MP0000778_abnormal_nervous_system0.82057513
82MP0004197_abnormal_fetal_growth/weight/0.80670812
83MP0003935_abnormal_craniofacial_develop0.77498335
84MP0005391_vision/eye_phenotype0.76016910
85MP0008932_abnormal_embryonic_tissue0.75905520
86MP0009053_abnormal_anal_canal0.75870567
87MP0005076_abnormal_cell_differentiation0.75480746
88MP0003984_embryonic_growth_retardation0.75385919
89MP0002751_abnormal_autonomic_nervous0.75248587
90MP0009250_abnormal_appendicular_skeleto0.75036384
91MP0003699_abnormal_female_reproductive0.74276060
92MP0002697_abnormal_eye_size0.74115915
93MP0006035_abnormal_mitochondrial_morpho0.73902528
94MP0000432_abnormal_head_morphology0.73731777
95MP0001697_abnormal_embryo_size0.71615236
96MP0001286_abnormal_eye_development0.71451579
97MP0002088_abnormal_embryonic_growth/wei0.71193246
98MP0003943_abnormal_hepatobiliary_system0.70586363
99MP0000003_abnormal_adipose_tissue0.69935725
100MP0002009_preneoplasia0.67336295
101MP0005253_abnormal_eye_physiology0.66838397
102MP0003385_abnormal_body_wall0.66062781
103MP0003646_muscle_fatigue0.64956731
104MP0006276_abnormal_autonomic_nervous0.64463033
105MP0005551_abnormal_eye_electrophysiolog0.64455231
106MP0000569_abnormal_digit_pigmentation0.63544104
107MP0003942_abnormal_urinary_system0.63510710
108MP0002116_abnormal_craniofacial_bone0.62923372
109MP0002932_abnormal_joint_morphology0.62639390
110MP0002184_abnormal_innervation0.62148705
111MP0002653_abnormal_ependyma_morphology0.62128061
112MP0001485_abnormal_pinna_reflex0.61902095
113MP0002086_abnormal_extraembryonic_tissu0.61859181
114MP0002080_prenatal_lethality0.61056411
115MP0001958_emphysema0.56898775
116MP0002081_perinatal_lethality0.54814897
117MP0003221_abnormal_cardiomyocyte_apopto0.54469117
118MP0003115_abnormal_respiratory_system0.53734958
119MP0010307_abnormal_tumor_latency0.52364666
120MP0000313_abnormal_cell_death0.52339468
121MP0000631_abnormal_neuroendocrine_gland0.51773171
122MP0002152_abnormal_brain_morphology0.51519993
123MP0001727_abnormal_embryo_implantation0.51134475
124MP0002114_abnormal_axial_skeleton0.48879143
125MP0000534_abnormal_ureter_morphology0.48333741
126MP0003936_abnormal_reproductive_system0.47848536
127MP0000049_abnormal_middle_ear0.47553387
128MP0001324_abnormal_eye_pigmentation0.47155081
129MP0002109_abnormal_limb_morphology0.46043438
130MP0001542_abnormal_bone_strength0.45982807

Predicted human phenotypes

RankGene SetZ-score
1Pelvic girdle muscle weakness (HP:0003749)6.32290384
2Azoospermia (HP:0000027)6.25374236
3Abnormality of the hip-girdle musculature (HP:0001445)5.52302803
4Abnormality of the musculature of the pelvis (HP:0001469)5.52302803
5Abnormal spermatogenesis (HP:0008669)5.15817242
6Papillary thyroid carcinoma (HP:0002895)3.94496284
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.93296166
8Cone-rod dystrophy (HP:0000548)3.73633300
9Meckel diverticulum (HP:0002245)3.70670758
10Abnormality of the lower motor neuron (HP:0002366)3.69277367
11Gonadotropin excess (HP:0000837)3.64913108
12Aplasia/Hypoplasia of the earlobes (HP:0009906)3.58183210
13Abnormality of the ileum (HP:0001549)3.57501860
14Anosmia (HP:0000458)3.41025688
15Abnormality of the preputium (HP:0100587)3.34447781
16Birth length less than 3rd percentile (HP:0003561)3.33453898
17Limb-girdle muscle weakness (HP:0003325)3.32675165
18Absent/shortened dynein arms (HP:0200106)3.27891633
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.27891633
20Renovascular hypertension (HP:0100817)3.26025809
21Small intestinal stenosis (HP:0012848)3.13956799
22Duodenal stenosis (HP:0100867)3.13956799
23Nephroblastoma (Wilms tumor) (HP:0002667)3.11034414
24Patellar aplasia (HP:0006443)3.00361125
25Abnormality of the intervertebral disk (HP:0005108)2.96309493
26Abnormal lung lobation (HP:0002101)2.95954838
27Chromsome breakage (HP:0040012)2.93234013
28Embryonal renal neoplasm (HP:0011794)2.92181574
29Palpebral edema (HP:0100540)2.89578905
30Volvulus (HP:0002580)2.86026944
31Abnormality of the duodenum (HP:0002246)2.84862717
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84371129
33Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.81573660
34Aplasia/Hypoplasia of the patella (HP:0006498)2.81566549
35Absent radius (HP:0003974)2.80024544
36Colon cancer (HP:0003003)2.77442289
37Abnormal respiratory motile cilium physiology (HP:0012261)2.74981349
38Nephronophthisis (HP:0000090)2.70934060
39Oligodactyly (hands) (HP:0001180)2.70440357
40Mask-like facies (HP:0000298)2.66569552
41Sandal gap (HP:0001852)2.65958322
42Triphalangeal thumb (HP:0001199)2.63630391
43Bell-shaped thorax (HP:0001591)2.62049223
44Aplasia involving forearm bones (HP:0009822)2.60233572
45Absent forearm bone (HP:0003953)2.60233572
46Esophageal atresia (HP:0002032)2.59499035
47Tubulointerstitial nephritis (HP:0001970)2.59167095
48Abnormality of the aortic arch (HP:0012303)2.57075895
49Abnormal respiratory epithelium morphology (HP:0012253)2.55703151
50Abnormal respiratory motile cilium morphology (HP:0005938)2.55703151
51Thyroid carcinoma (HP:0002890)2.52506844
52Male infertility (HP:0003251)2.48349607
53Sloping forehead (HP:0000340)2.48025558
54Truncal obesity (HP:0001956)2.46248093
55Hypothermia (HP:0002045)2.46156232
56Clubbing of toes (HP:0100760)2.46054003
57Abnormal ciliary motility (HP:0012262)2.43530270
58Rhabdomyosarcoma (HP:0002859)2.42250311
59Gastrointestinal atresia (HP:0002589)2.40593201
60Facial hemangioma (HP:0000329)2.39173902
61Elfin facies (HP:0004428)2.38843878
62Supernumerary spleens (HP:0009799)2.38110507
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.33800907
64Facial cleft (HP:0002006)2.31524373
65Intellectual disability, moderate (HP:0002342)2.30120294
66Gynecomastia (HP:0000771)2.28950818
67Ependymoma (HP:0002888)2.21255568
68Male pseudohermaphroditism (HP:0000037)2.21071519
69Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.20823390
70Myelodysplasia (HP:0002863)2.19828114
71Rhinitis (HP:0012384)2.19364797
72Wrist flexion contracture (HP:0001239)2.18647038
73Increased nuchal translucency (HP:0010880)2.18059104
74Glioma (HP:0009733)2.17717546
75Chronic hepatic failure (HP:0100626)2.17223139
76Medulloblastoma (HP:0002885)2.16814992
77Duplication of thumb phalanx (HP:0009942)2.16715251
78Abnormality of cochlea (HP:0000375)2.15851723
79Median cleft lip (HP:0000161)2.15761777
80Abnormality of the astrocytes (HP:0100707)2.13095455
81Astrocytoma (HP:0009592)2.13095455
82Trigonocephaly (HP:0000243)2.12003350
83Fibular hypoplasia (HP:0003038)2.11919326
84Abnormality of the fingertips (HP:0001211)2.10298041
85Intestinal atresia (HP:0011100)2.10296686
86Abnormality of the epiphyses of the hand (HP:0005924)2.10050765
87Cortical dysplasia (HP:0002539)2.08457063
88Poor coordination (HP:0002370)2.08445241
89Heterotopia (HP:0002282)2.08213627
90Subacute progressive viral hepatitis (HP:0006572)2.08063608
91Breast aplasia (HP:0100783)2.07375082
92Reticulocytopenia (HP:0001896)2.06238259
93Abnormality of the labia minora (HP:0012880)2.05864436
94Glucose intolerance (HP:0000833)2.02866058
95Hand muscle atrophy (HP:0009130)2.02463050
96Abnormal sex determination (HP:0012244)2.02111473
97Sex reversal (HP:0012245)2.02111473
98Abnormality of the renal medulla (HP:0100957)2.01731905
99Oligodactyly (HP:0012165)2.00358277
100Cafe-au-lait spot (HP:0000957)2.00013566
101Impulsivity (HP:0100710)1.99812606
102Cutis marmorata (HP:0000965)1.99747352
103Primary amenorrhea (HP:0000786)1.98836927
104Slow-growing hair (HP:0002217)1.98692813
105Abnormality of hair growth rate (HP:0011363)1.98692813
106Neoplasm of the oral cavity (HP:0100649)1.98478160
107Clitoromegaly (HP:0000057)1.98212025
108Preaxial hand polydactyly (HP:0001177)1.97865600
109Abnormality of the septum pellucidum (HP:0007375)1.97116317
110Bifid tongue (HP:0010297)1.96187322
111Selective tooth agenesis (HP:0001592)1.95492649
112Cutaneous finger syndactyly (HP:0010554)1.95048310
113Postaxial foot polydactyly (HP:0001830)1.94884644
114Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.94158094
115Prominent nose (HP:0000448)1.92980158
116Abnormal number of incisors (HP:0011064)1.92795587
117Neoplasm of the colon (HP:0100273)1.91481136
118Choanal atresia (HP:0000453)1.90610945
119Degeneration of anterior horn cells (HP:0002398)1.89669679
120Abnormality of the anterior horn cell (HP:0006802)1.89669679
121Absent septum pellucidum (HP:0001331)1.89612673
122Medial flaring of the eyebrow (HP:0010747)1.88539880
123Decreased central vision (HP:0007663)1.88491439
124Ectopic kidney (HP:0000086)1.88296980
125Shawl scrotum (HP:0000049)1.87703980
126Spina bifida occulta (HP:0003298)1.87462593
127Embryonal neoplasm (HP:0002898)1.86668450
128Inappropriate behavior (HP:0000719)1.86420658
129Bilateral microphthalmos (HP:0007633)1.86004808
130Ankle contracture (HP:0006466)1.84728001
131Abnormality of chromosome segregation (HP:0002916)1.84493406
132Underdeveloped nasal alae (HP:0000430)1.83496705
133Arteriovenous malformation (HP:0100026)1.83472948
134Microglossia (HP:0000171)1.82403228
135Abnormality of chromosome stability (HP:0003220)1.82167394
136Aplasia/Hypoplasia of the breasts (HP:0010311)1.81932145
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.80922398
138Septo-optic dysplasia (HP:0100842)1.80751955
139Hypoplastic labia majora (HP:0000059)1.78817655
140Long eyelashes (HP:0000527)1.78697651
141Short ribs (HP:0000773)1.78157839
142Enlarged penis (HP:0000040)1.76861340
143Proximal placement of thumb (HP:0009623)1.76147870
144Short thumb (HP:0009778)1.75689267
145Abdominal situs inversus (HP:0003363)1.73696693
146Abnormality of abdominal situs (HP:0011620)1.73696693
147Decreased testicular size (HP:0008734)1.72776887
148Abnormality of the carotid arteries (HP:0005344)1.71628217
149Convex nasal ridge (HP:0000444)1.70733493
150Small hand (HP:0200055)1.70582783
151Short tibia (HP:0005736)1.70541281
152Abnormality of the phalanges of the hallux (HP:0010057)1.70171008
153Atresia of the external auditory canal (HP:0000413)1.69947381
154Polycystic ovaries (HP:0000147)1.69807244
155Gait imbalance (HP:0002141)1.69339119
156Infertility (HP:0000789)1.69285594
15711 pairs of ribs (HP:0000878)1.68450316
158Cutaneous syndactyly (HP:0012725)1.67197636
159Horseshoe kidney (HP:0000085)1.67003557
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.66572510
161Neoplasm of striated muscle (HP:0009728)1.63773901
162Abnormality of the labia majora (HP:0012881)1.61681278
163Hypoplasia of the pons (HP:0012110)1.61552380
164Aqueductal stenosis (HP:0002410)1.61241959
165Astigmatism (HP:0000483)1.60128850
166Biliary tract neoplasm (HP:0100574)1.57187574
167Megaloblastic anemia (HP:0001889)1.56959978
168Morphological abnormality of the inner ear (HP:0011390)1.55151699
169Absent thumb (HP:0009777)1.54404205
170Duplicated collecting system (HP:0000081)1.54101002
171Capillary hemangiomas (HP:0005306)1.53366897
172Abnormality of the pons (HP:0007361)1.52284210
173Pancreatic fibrosis (HP:0100732)1.52252752
174Premature ovarian failure (HP:0008209)1.51746434
175Abnormality of the clitoris (HP:0000056)1.49440374
176Neoplasm of the small intestine (HP:0100833)1.47976079
177Partial duplication of thumb phalanx (HP:0009944)1.47891313
178Agnosia (HP:0010524)1.47570276
179Facial asymmetry (HP:0000324)1.46389062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.50179663
2ERBB36.15777534
3CDK124.39358021
4BUB13.85593037
5PLK23.38134464
6BMPR23.27136814
7CDC73.17682181
8BRD43.10599212
9ACVR1B2.82288106
10BLK2.72772711
11PNCK2.55249829
12TSSK62.46650153
13BRSK22.30297270
14MAP3K42.21626242
15PBK2.19844845
16NEK22.09482088
17INSRR2.03089488
18BMPR1B2.01536367
19FGFR21.70505389
20PDK41.59443759
21PDK31.59443759
22TNIK1.50375021
23STK161.45859926
24ICK1.36165932
25TAF11.32666953
26BRSK11.30896545
27MAP3K61.30865194
28MAP2K71.30668063
29WNK31.26668615
30STK38L1.20646777
31TTK1.19324960
32SRPK11.14668855
33TNK21.14458412
34STK31.13910657
35CDK191.11971535
36PLK11.11508106
37EIF2AK31.06612949
38CHEK11.05499591
39VRK20.99329752
40ATR0.99012461
41TYRO30.94514038
42TLK10.91974652
43PRKD30.91318435
44CCNB10.83524177
45STK40.82835159
46PLK30.81473207
47BRAF0.79089182
48MTOR0.78626952
49TGFBR10.78428087
50AKT30.76478907
51EIF2AK20.75596629
52TRIM280.75529626
53ATM0.74864154
54CHEK20.73602457
55CDK20.70837006
56CDK90.70675462
57EIF2AK10.70602436
58FRK0.70239290
59EEF2K0.68837566
60PDK20.67851152
61FGFR10.66126890
62DYRK30.64508751
63DYRK20.63258742
64OXSR10.62632164
65CASK0.61524818
66AURKB0.57988649
67MKNK10.57612185
68CDK70.56451021
69MAP4K20.55509297
70CDK80.55495414
71LATS10.55436431
72STK240.55415687
73SIK20.54568380
74ALK0.53932768
75WNK10.53532274
76CAMK1D0.53487648
77MAP2K40.53190973
78CSNK1A1L0.53106500
79MET0.53056786
80ZAK0.53009918
81CDK40.52869896
82CDK10.52632937
83MKNK20.52340017
84CDK60.48656011
85MAP3K20.47951567
86RPS6KB20.46918436
87GSK3B0.45640369
88MAP3K100.45537635
89MST40.44191070
90RIPK10.43674500
91NME10.42961477
92NEK60.42745276
93MAP3K80.41287934
94CSF1R0.41134252
95CSNK1G20.40732970
96MAP3K90.39212133
97RAF10.38987979
98WEE10.38343401
99MAPK130.37658403
100CSNK2A10.37612725
101STK110.35948146
102MAPK140.35491942
103PASK0.35262281
104STK390.33194912
105MAPK150.33147946
106VRK10.32430242
107CSNK1E0.31849609
108DAPK20.31794151
109DMPK0.31042304
110MAPK80.30822029
111AURKA0.29698862
112CHUK0.29309642
113PRKACB0.29219257
114WNK40.29186853
115CSNK1D0.29134805
116MELK0.28789616
117LATS20.28311876
118MARK30.28248307
119RPS6KB10.28174774
120MAPKAPK50.28168624
121PRKDC0.28168080
122CSNK1G10.27900209
123NEK10.27514029
124DYRK1A0.26860344
125SGK2230.26693334
126SGK4940.26693334
127FER0.26176948
128CDK30.26034730
129PHKG10.25498482
130PHKG20.25498482
131CAMK1G0.25416444
132CLK10.25392834
133PTK2B0.24097012
134LMTK20.23815782
135NUAK10.23028599
136CSNK1G30.22067985
137CSNK2A20.21726931
138SGK20.21499371
139SIK10.21397509
140RET0.20909046
141KSR10.20761994
142MAPK100.20574764

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.16537666
2Basal transcription factors_Homo sapiens_hsa030224.12124190
3Non-homologous end-joining_Homo sapiens_hsa034503.50471799
4Dorso-ventral axis formation_Homo sapiens_hsa043203.44683453
5RNA transport_Homo sapiens_hsa030133.07890928
6mRNA surveillance pathway_Homo sapiens_hsa030152.95960411
7RNA polymerase_Homo sapiens_hsa030202.83238481
8Fanconi anemia pathway_Homo sapiens_hsa034602.71662315
9Cell cycle_Homo sapiens_hsa041102.58795973
10Notch signaling pathway_Homo sapiens_hsa043302.43529803
11Spliceosome_Homo sapiens_hsa030402.28493592
12Adherens junction_Homo sapiens_hsa045202.19225329
13RNA degradation_Homo sapiens_hsa030181.95706944
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.79161224
15Lysine degradation_Homo sapiens_hsa003101.76794122
16Homologous recombination_Homo sapiens_hsa034401.75409400
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66941668
18DNA replication_Homo sapiens_hsa030301.48279643
19TGF-beta signaling pathway_Homo sapiens_hsa043501.47700894
20Oocyte meiosis_Homo sapiens_hsa041141.44733344
21FoxO signaling pathway_Homo sapiens_hsa040681.44250777
22Epstein-Barr virus infection_Homo sapiens_hsa051691.44233160
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41923338
24Ribosome_Homo sapiens_hsa030101.34425816
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33131662
26Endometrial cancer_Homo sapiens_hsa052131.27962241
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24931575
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21931434
29Base excision repair_Homo sapiens_hsa034101.20747169
30Selenocompound metabolism_Homo sapiens_hsa004501.20572684
31Herpes simplex infection_Homo sapiens_hsa051681.18565544
32Purine metabolism_Homo sapiens_hsa002301.14316383
33Mismatch repair_Homo sapiens_hsa034301.13290166
34Nucleotide excision repair_Homo sapiens_hsa034201.10407175
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09304196
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08910917
37Phototransduction_Homo sapiens_hsa047441.07882039
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07716235
39Chronic myeloid leukemia_Homo sapiens_hsa052201.07478023
40Colorectal cancer_Homo sapiens_hsa052101.06053549
41One carbon pool by folate_Homo sapiens_hsa006701.05951980
42Renal cell carcinoma_Homo sapiens_hsa052111.05663564
43Tight junction_Homo sapiens_hsa045301.02474681
44Viral carcinogenesis_Homo sapiens_hsa052031.02301068
45Wnt signaling pathway_Homo sapiens_hsa043101.01741076
46MicroRNAs in cancer_Homo sapiens_hsa052061.00700269
47Thyroid cancer_Homo sapiens_hsa052160.98994288
48Proteasome_Homo sapiens_hsa030500.98546615
49p53 signaling pathway_Homo sapiens_hsa041150.97834492
50Protein export_Homo sapiens_hsa030600.97192163
51Olfactory transduction_Homo sapiens_hsa047400.95988306
52Basal cell carcinoma_Homo sapiens_hsa052170.89727596
53Alcoholism_Homo sapiens_hsa050340.89277810
54Biosynthesis of amino acids_Homo sapiens_hsa012300.87576737
55ErbB signaling pathway_Homo sapiens_hsa040120.87232332
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.86912159
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86440087
58Systemic lupus erythematosus_Homo sapiens_hsa053220.85371676
59Prolactin signaling pathway_Homo sapiens_hsa049170.83182466
60Small cell lung cancer_Homo sapiens_hsa052220.82368027
61Glioma_Homo sapiens_hsa052140.81930281
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81421371
63Pyrimidine metabolism_Homo sapiens_hsa002400.81373486
64Prostate cancer_Homo sapiens_hsa052150.81334133
65Parkinsons disease_Homo sapiens_hsa050120.80852495
66Acute myeloid leukemia_Homo sapiens_hsa052210.80132288
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76991813
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74724110
69Vitamin B6 metabolism_Homo sapiens_hsa007500.74394887
70Hippo signaling pathway_Homo sapiens_hsa043900.73845367
71Folate biosynthesis_Homo sapiens_hsa007900.72974570
72Steroid biosynthesis_Homo sapiens_hsa001000.71719558
73Non-small cell lung cancer_Homo sapiens_hsa052230.69500420
74Pancreatic cancer_Homo sapiens_hsa052120.69443127
75Influenza A_Homo sapiens_hsa051640.69249352
76HTLV-I infection_Homo sapiens_hsa051660.66796295
77Fatty acid elongation_Homo sapiens_hsa000620.66094501
78Hepatitis C_Homo sapiens_hsa051600.65399234
79Type II diabetes mellitus_Homo sapiens_hsa049300.64507817
80Oxidative phosphorylation_Homo sapiens_hsa001900.62885807
81Pathways in cancer_Homo sapiens_hsa052000.61738636
82Nitrogen metabolism_Homo sapiens_hsa009100.60881215
83Fatty acid biosynthesis_Homo sapiens_hsa000610.59845290
84Butanoate metabolism_Homo sapiens_hsa006500.58608694
85Pyruvate metabolism_Homo sapiens_hsa006200.56686397
86mTOR signaling pathway_Homo sapiens_hsa041500.55431373
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54398123
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54366023
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53539201
90Nicotine addiction_Homo sapiens_hsa050330.53384940
91Inositol phosphate metabolism_Homo sapiens_hsa005620.51953623
92Carbon metabolism_Homo sapiens_hsa012000.51932918
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50974259
94Ovarian steroidogenesis_Homo sapiens_hsa049130.50272074
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48468422
96Hedgehog signaling pathway_Homo sapiens_hsa043400.45437254
97Fatty acid metabolism_Homo sapiens_hsa012120.44273115
98Arginine biosynthesis_Homo sapiens_hsa002200.44041762
99Glucagon signaling pathway_Homo sapiens_hsa049220.43935310
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43842832
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43654547
102Ether lipid metabolism_Homo sapiens_hsa005650.42842465
103Vitamin digestion and absorption_Homo sapiens_hsa049770.42812723
104Focal adhesion_Homo sapiens_hsa045100.42523830
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41252295
106Linoleic acid metabolism_Homo sapiens_hsa005910.41094631
107Insulin signaling pathway_Homo sapiens_hsa049100.40100524
108ECM-receptor interaction_Homo sapiens_hsa045120.38838239
109Huntingtons disease_Homo sapiens_hsa050160.38710092
110Axon guidance_Homo sapiens_hsa043600.38142256
111Metabolic pathways_Homo sapiens_hsa011000.38130244
112Choline metabolism in cancer_Homo sapiens_hsa052310.37147193
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34179272
114Estrogen signaling pathway_Homo sapiens_hsa049150.33299932
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33124151
116Proteoglycans in cancer_Homo sapiens_hsa052050.32807838
117Arginine and proline metabolism_Homo sapiens_hsa003300.32494030
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32466020
119Taste transduction_Homo sapiens_hsa047420.31873746
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.31115565
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29334680
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29269291
123Propanoate metabolism_Homo sapiens_hsa006400.29187839
124Glutathione metabolism_Homo sapiens_hsa004800.29030601
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.28709676
126MAPK signaling pathway_Homo sapiens_hsa040100.28216971
127Alzheimers disease_Homo sapiens_hsa050100.27151587
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26280331
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26250391
130T cell receptor signaling pathway_Homo sapiens_hsa046600.26098786
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24903465
132Glycerolipid metabolism_Homo sapiens_hsa005610.24305255
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23594603
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.23235768
135Ras signaling pathway_Homo sapiens_hsa040140.23179076
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23010670
137Caffeine metabolism_Homo sapiens_hsa002320.20545903
138Gap junction_Homo sapiens_hsa045400.19826190
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19771656
140N-Glycan biosynthesis_Homo sapiens_hsa005100.19551317
141Melanoma_Homo sapiens_hsa052180.16574552
142Fatty acid degradation_Homo sapiens_hsa000710.16237454
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16012281
144beta-Alanine metabolism_Homo sapiens_hsa004100.15369175
145Circadian rhythm_Homo sapiens_hsa047100.13602596
146Tryptophan metabolism_Homo sapiens_hsa003800.12958597
147Retinol metabolism_Homo sapiens_hsa008300.12862507

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