TEX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.04980427
2L-phenylalanine catabolic process (GO:0006559)6.04980427
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.67082832
4L-phenylalanine metabolic process (GO:0006558)5.67082832
5aromatic amino acid family catabolic process (GO:0009074)5.41690550
6sperm motility (GO:0030317)5.28264424
7alpha-linolenic acid metabolic process (GO:0036109)5.03326903
8fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96412479
9urea cycle (GO:0000050)4.95503072
10urea metabolic process (GO:0019627)4.95503072
11kynurenine metabolic process (GO:0070189)4.84465706
12hemidesmosome assembly (GO:0031581)4.84123176
13bile acid biosynthetic process (GO:0006699)4.83082311
14tryptophan catabolic process (GO:0006569)4.82199475
15indole-containing compound catabolic process (GO:0042436)4.82199475
16indolalkylamine catabolic process (GO:0046218)4.82199475
17acrosome reaction (GO:0007340)4.78523019
18fusion of sperm to egg plasma membrane (GO:0007342)4.72128672
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.62234014
20sulfur amino acid catabolic process (GO:0000098)4.51947017
21tryptophan metabolic process (GO:0006568)4.51374696
22nitrogen cycle metabolic process (GO:0071941)4.50459469
23glyoxylate metabolic process (GO:0046487)4.43263679
24regulation of triglyceride catabolic process (GO:0010896)4.38446745
25high-density lipoprotein particle remodeling (GO:0034375)4.38109454
26complement activation, alternative pathway (GO:0006957)4.37678008
27cysteine metabolic process (GO:0006534)4.34353684
28amino-acid betaine metabolic process (GO:0006577)4.28070244
29regulation of protein activation cascade (GO:2000257)4.21996507
30bile acid metabolic process (GO:0008206)4.13701029
31regulation of skeletal muscle contraction (GO:0014819)4.11817058
32organic cation transport (GO:0015695)4.10771779
33acrosome assembly (GO:0001675)4.09531763
34tyrosine metabolic process (GO:0006570)4.08331004
35negative regulation of fibrinolysis (GO:0051918)4.05814405
36peptidyl-glutamic acid carboxylation (GO:0017187)4.03531272
37protein carboxylation (GO:0018214)4.03531272
38aromatic amino acid family metabolic process (GO:0009072)3.98254947
39regulation of complement activation (GO:0030449)3.97005401
40cell wall macromolecule metabolic process (GO:0044036)3.96326462
41cell wall macromolecule catabolic process (GO:0016998)3.96326462
42coenzyme catabolic process (GO:0009109)3.89949877
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.88880144
44lysine metabolic process (GO:0006553)3.88449149
45lysine catabolic process (GO:0006554)3.88449149
46serine family amino acid catabolic process (GO:0009071)3.88230948
47sperm-egg recognition (GO:0035036)3.87291084
48regulation of fibrinolysis (GO:0051917)3.84696209
49protein-lipid complex remodeling (GO:0034368)3.83929892
50macromolecular complex remodeling (GO:0034367)3.83929892
51plasma lipoprotein particle remodeling (GO:0034369)3.83929892
52reverse cholesterol transport (GO:0043691)3.78920127
53cilium or flagellum-dependent cell motility (GO:0001539)3.78834553
54alpha-amino acid catabolic process (GO:1901606)3.73250202
55dicarboxylic acid biosynthetic process (GO:0043650)3.72684509
56multicellular organism reproduction (GO:0032504)3.68788494
57desmosome organization (GO:0002934)3.67525902
58plasma membrane fusion (GO:0045026)3.67132216
59acylglycerol homeostasis (GO:0055090)3.61688507
60triglyceride homeostasis (GO:0070328)3.61688507
61homocysteine metabolic process (GO:0050667)3.61518671
62regulation of cholesterol esterification (GO:0010872)3.58979412
63aspartate family amino acid catabolic process (GO:0009068)3.53097370
64binding of sperm to zona pellucida (GO:0007339)3.51799253
65cell-cell recognition (GO:0009988)3.51772008
66carnitine transport (GO:0015879)3.50227995
67amino-acid betaine transport (GO:0015838)3.50227995
68glutamate metabolic process (GO:0006536)3.49865198
69cellular amino acid catabolic process (GO:0009063)3.49421090
70plasma lipoprotein particle clearance (GO:0034381)3.48827416
71bile acid and bile salt transport (GO:0015721)3.46734894
72carnitine metabolic process (GO:0009437)3.45149560
73carnitine transmembrane transport (GO:1902603)3.43601059
74sodium ion export (GO:0071436)3.43571634
75benzene-containing compound metabolic process (GO:0042537)3.42751998
76cellular glucuronidation (GO:0052695)3.42218612
77cellular modified amino acid catabolic process (GO:0042219)3.42084246
78phospholipid efflux (GO:0033700)3.41917410
79drug transmembrane transport (GO:0006855)3.40995627
80indolalkylamine metabolic process (GO:0006586)3.35266472
81cellular ketone body metabolic process (GO:0046950)3.34941043
82low-density lipoprotein particle remodeling (GO:0034374)3.33919771
83cytoskeletal anchoring at plasma membrane (GO:0007016)3.33341281
84spermatid development (GO:0007286)3.32764433
85phospholipid homeostasis (GO:0055091)3.31735094
86cell-substrate junction assembly (GO:0007044)3.30186096
87short-chain fatty acid metabolic process (GO:0046459)3.30185453
88drug catabolic process (GO:0042737)3.28828979
89reproduction (GO:0000003)3.26696544
90negative regulation of sterol transport (GO:0032372)3.26602434
91negative regulation of cholesterol transport (GO:0032375)3.26602434
92axonemal dynein complex assembly (GO:0070286)3.25233450
93cholesterol efflux (GO:0033344)3.24959611
94positive regulation of lipid catabolic process (GO:0050996)3.24470544
95ethanol oxidation (GO:0006069)3.18625075
96acetyl-CoA metabolic process (GO:0006084)3.16013914
97cytolysis (GO:0019835)3.14920587
98cofactor catabolic process (GO:0051187)3.14752091
99organic acid catabolic process (GO:0016054)3.14571677
100carboxylic acid catabolic process (GO:0046395)3.14571677
101monocarboxylic acid catabolic process (GO:0072329)3.14057754
102epithelial cilium movement (GO:0003351)3.13905844
103fatty acid beta-oxidation (GO:0006635)3.13580996
104fructose metabolic process (GO:0006000)3.13216123
105killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.13116901
106disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.13116901
107fatty acid catabolic process (GO:0009062)3.12539394
108cellular potassium ion homeostasis (GO:0030007)2.98392150
109response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.87567836
110cellular response to ATP (GO:0071318)2.79098787
111glutamate secretion (GO:0014047)2.76402269
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.72176820
113melanin biosynthetic process (GO:0042438)2.67243878
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63637601
115semaphorin-plexin signaling pathway (GO:0071526)2.63284345
116regulation of synapse structural plasticity (GO:0051823)2.63095542
117plasma membrane repair (GO:0001778)2.61251172
118cell-substrate adherens junction assembly (GO:0007045)2.60323897
119focal adhesion assembly (GO:0048041)2.60323897
120negative regulation of fatty acid transport (GO:2000192)2.60132750
121phosphate ion transmembrane transport (GO:0035435)2.57281179
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56916037
123regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53275383
124urinary tract smooth muscle contraction (GO:0014848)2.42943657
125bundle of His cell to Purkinje myocyte communication (GO:0086069)2.41439988
126regulation of fatty acid oxidation (GO:0046320)2.40185784
127regulation of fatty acid beta-oxidation (GO:0031998)2.39460809
128cell communication involved in cardiac conduction (GO:0086065)2.38994730
129regulation of cholesterol biosynthetic process (GO:0045540)2.38534679
130adherens junction assembly (GO:0034333)2.34561647
131basement membrane organization (GO:0071711)2.33953970
132melanin metabolic process (GO:0006582)2.33817675
133positive regulation of synapse maturation (GO:0090129)2.32416239
134regulation of cholesterol homeostasis (GO:2000188)2.30543580
135stress fiber assembly (GO:0043149)2.26462216
136vesicle transport along microtubule (GO:0047496)2.22884500
137musculoskeletal movement (GO:0050881)2.22385550
138multicellular organismal movement (GO:0050879)2.22385550
139cell adhesion mediated by integrin (GO:0033627)2.20684474
140macroautophagy (GO:0016236)2.18649488
141negative regulation of Rho protein signal transduction (GO:0035024)2.17523089
142adenosine receptor signaling pathway (GO:0001973)2.17162930
143hyaluronan catabolic process (GO:0030214)2.15048801
144activation of protein kinase A activity (GO:0034199)2.14353660
145skin morphogenesis (GO:0043589)2.14206947
146cell communication by electrical coupling (GO:0010644)2.13502967
147regulation of phospholipid biosynthetic process (GO:0071071)2.13469247
148protein hydroxylation (GO:0018126)2.12710205
149negative regulation of dendrite morphogenesis (GO:0050774)2.12316543
150negative regulation of protein localization to cell surface (GO:2000009)2.12101187
151potassium ion homeostasis (GO:0055075)2.09043226
152neuromuscular synaptic transmission (GO:0007274)2.08904854
153iron ion import (GO:0097286)2.08758029
154regulation of the force of heart contraction (GO:0002026)2.08560300
155apoptotic cell clearance (GO:0043277)2.08280071
156regulation of ARF protein signal transduction (GO:0032012)2.06127618
157endocytic recycling (GO:0032456)2.05895168
158regulation of early endosome to late endosome transport (GO:2000641)2.05583404
159hypotonic response (GO:0006971)2.04740327
160positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.03963906
161biotin metabolic process (GO:0006768)2.03825312
162detection of light stimulus involved in visual perception (GO:0050908)2.03751330
163detection of light stimulus involved in sensory perception (GO:0050962)2.03751330
164very-low-density lipoprotein particle assembly (GO:0034379)2.03567128
165positive regulation of fatty acid beta-oxidation (GO:0032000)2.02658899
166carnitine shuttle (GO:0006853)2.02532716
167negative regulation of keratinocyte proliferation (GO:0010839)2.02281844
168regulation of cholesterol metabolic process (GO:0090181)2.01777947
169type B pancreatic cell proliferation (GO:0044342)2.01731608
170mannose metabolic process (GO:0006013)2.01455361
171actin filament bundle organization (GO:0061572)2.01248405
172actin filament bundle assembly (GO:0051017)2.01248405
173positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.01129495
174endocardial cushion development (GO:0003197)2.01085117
175negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.00876104
176positive regulation of fatty acid oxidation (GO:0046321)1.98655533
177import into cell (GO:0098657)1.98111257
178regulation of NFAT protein import into nucleus (GO:0051532)1.97234703
179ventricular cardiac muscle cell action potential (GO:0086005)1.97157443
180phosphate ion transport (GO:0006817)1.96096443
181regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.95960235
182sarcomere organization (GO:0045214)1.95581657
183chemical homeostasis within a tissue (GO:0048875)1.94729408
184cellular sodium ion homeostasis (GO:0006883)1.94662570
185meiotic chromosome segregation (GO:0045132)1.93802297
186fatty acid transmembrane transport (GO:1902001)1.93406459
187regulation of water loss via skin (GO:0033561)1.93078422
188synaptic vesicle maturation (GO:0016188)1.92900836
189Golgi to plasma membrane transport (GO:0006893)1.91285816
190sphingomyelin metabolic process (GO:0006684)1.91171205
191protein retention in ER lumen (GO:0006621)1.91024155
192Golgi to plasma membrane protein transport (GO:0043001)1.89839821
193regulation of sodium ion transport (GO:0002028)1.88252528
194synaptic vesicle exocytosis (GO:0016079)1.87783772
195neuromuscular process controlling balance (GO:0050885)1.87537487
196myelin maintenance (GO:0043217)1.87380940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.71949187
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.55538908
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.78927499
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.70898420
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.20890135
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.93194545
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.92972531
8ESR2_21235772_ChIP-Seq_MCF-7_Human3.11600477
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.97973984
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.95618284
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.92221337
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.72138656
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65612981
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55690171
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.42712016
16* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42554873
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36214764
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33304685
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.18685030
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14946667
21LXR_22292898_ChIP-Seq_THP-1_Human2.06397915
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.01369488
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01170761
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86019150
25EZH2_22144423_ChIP-Seq_EOC_Human1.85051324
26* RACK7_27058665_Chip-Seq_MCF-7_Human1.80368491
27CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.67431647
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.64634303
29P68_20966046_ChIP-Seq_HELA_Human1.62948141
30GATA1_22025678_ChIP-Seq_K562_Human1.59742924
31SMC4_20622854_ChIP-Seq_HELA_Human1.55663846
32KDM2B_26808549_Chip-Seq_K562_Human1.55144848
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53468356
34CTCF_27219007_Chip-Seq_Bcells_Human1.52445232
35TAF15_26573619_Chip-Seq_HEK293_Human1.50805077
36* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50383472
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49403507
38* FOXA2_19822575_ChIP-Seq_HepG2_Human1.48787693
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.46155019
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45722499
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45319133
42CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45095989
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43585769
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43553359
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41654963
46TP53_22127205_ChIP-Seq_IMR90_Human1.40541029
47VDR_21846776_ChIP-Seq_THP-1_Human1.38596229
48* UBF1/2_26484160_Chip-Seq_HMECs_Human1.38264985
49* TBX20_22328084_ChIP-Seq_HEART_Mouse1.37101843
50* TBX20_22080862_ChIP-Seq_HEART_Mouse1.37101843
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33862088
52HTT_18923047_ChIP-ChIP_STHdh_Human1.33428689
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33092435
54* TP53_23651856_ChIP-Seq_MEFs_Mouse1.32647855
55TET1_21490601_ChIP-Seq_MESCs_Mouse1.30677749
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28792967
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28559964
58* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28527836
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27072243
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27042981
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26242499
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25591883
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.25551949
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24923041
65CREB1_26743006_Chip-Seq_LNCaP_Human1.22316523
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21282061
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21045714
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20570488
69ATF3_27146783_Chip-Seq_COLON_Human1.20017026
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18402416
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18024869
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17497610
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17497610
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16829458
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15639711
76* TP63_22573176_ChIP-Seq_HFKS_Human1.14949203
77GATA1_19941826_ChIP-Seq_K562_Human1.14653424
78CLOCK_20551151_ChIP-Seq_293T_Human1.14583098
79* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13905297
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13346474
81EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13346474
82* GATA2_21666600_ChIP-Seq_HMVEC_Human1.13272610
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13238806
84* MITF_21258399_ChIP-Seq_MELANOMA_Human1.12213285
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11480982
86AR_21572438_ChIP-Seq_LNCaP_Human1.11051545
87RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10566524
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10556397
89* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10519970
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09035981
91REST_21632747_ChIP-Seq_MESCs_Mouse1.08350873
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.07640152
93VDR_22108803_ChIP-Seq_LS180_Human1.07253297
94KDM2B_26808549_Chip-Seq_DND41_Human1.06746327
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05189655
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04727355
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04623836
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04458798
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.02438420
100TCF7_22412390_ChIP-Seq_EML_Mouse1.01437225
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00701634
102STAT1_17558387_ChIP-Seq_HELA_Human0.98643761
103* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98081137
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97927513
105CBP_20019798_ChIP-Seq_JUKART_Human0.97927513
106* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97485347
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96624556
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95871581
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95438453
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95326488
111KDM2B_26808549_Chip-Seq_REH_Human0.95107206
112* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94913800
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94846926
114CJUN_26792858_Chip-Seq_BT549_Human0.94814478
115ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92147215
116* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91832055
117* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90823934
118FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90619999
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90613483
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89836062
121ZNF263_19887448_ChIP-Seq_K562_Human0.86886560
122* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.86834931
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.86798124
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.85909223
125* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85879390
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85107518
127* P53_21459846_ChIP-Seq_SAOS-2_Human0.84514440
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84218691
129BCAT_22108803_ChIP-Seq_LS180_Human0.84218338
130* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82397380
131AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82259066
132* FLI1_21867929_ChIP-Seq_TH2_Mouse0.82155344
133* SMAD4_21799915_ChIP-Seq_A2780_Human0.81381120
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81318910
135* ESET_19884257_ChIP-Seq_ESCs_Mouse0.81042647
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80786167
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.80601311
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.80051377
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79748784
140SOX2_22085726_ChIP-Seq_NPCs_Mouse0.79630909
141* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74847321
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.74066037
143* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73880830
144MYC_19915707_ChIP-ChIP_AK7_Human0.73747164
145* CRX_20693478_ChIP-Seq_RETINA_Mouse0.72950747
146ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.72872989
147GF1_26923725_Chip-Seq_HPCs_Mouse0.72756702
148CDX2_22108803_ChIP-Seq_LS180_Human0.72567654
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.71878248
150CBP_21632823_ChIP-Seq_H3396_Human0.71467924
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71371600
152SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.70877729
153* REST_18959480_ChIP-ChIP_MESCs_Mouse0.70717242
154ERG_20517297_ChIP-Seq_VCAP_Human0.70343495
155UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.70023192
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69946358
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69645114
158* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69364561
159NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.68744880
160RARB_27405468_Chip-Seq_BRAIN_Mouse0.68615583
161OCT4_20526341_ChIP-Seq_ESCs_Human0.68609062
162AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68591593
163NFE2_27457419_Chip-Seq_LIVER_Mouse0.68482836
164AHR_22903824_ChIP-Seq_MCF-7_Human0.67632604
165* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.67473525
166* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67279451
167ARNT_22903824_ChIP-Seq_MCF-7_Human0.67117922
168BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66846437
169* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.66412008
170* KLF4_19829295_ChIP-Seq_ESCs_Human0.66283812
171STAT3_23295773_ChIP-Seq_U87_Human0.65997833
172SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.65987921
173OCT1_27270436_Chip-Seq_PROSTATE_Human0.65883635
174FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65464564
175* TCF4_23295773_ChIP-Seq_U87_Human0.65139309
176DROSHA_22980978_ChIP-Seq_HELA_Human0.65116341
177KLF5_20875108_ChIP-Seq_MESCs_Mouse0.64903276
178GATA3_21867929_ChIP-Seq_CD8_Mouse0.64482631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.84920255
2MP0005360_urolithiasis6.31522766
3MP0005410_abnormal_fertilization5.57638197
4MP0005085_abnormal_gallbladder_physiolo5.33309188
5MP0005365_abnormal_bile_salt5.28368042
6MP0008875_abnormal_xenobiotic_pharmacok4.44215307
7MP0005171_absent_coat_pigmentation4.01361096
8MP0000751_myopathy3.35238509
9MP0003806_abnormal_nucleotide_metabolis3.31269279
10MP0010329_abnormal_lipoprotein_level3.26837911
11MP0003252_abnormal_bile_duct3.24859316
12MP0005409_darkened_coat_color3.14912928
13MP0003705_abnormal_hypodermis_morpholog3.06575345
14MP0005423_abnormal_somatic_nervous3.06161847
15MP0005332_abnormal_amino_acid2.40434847
16MP0009840_abnormal_foam_cell2.36181035
17MP0000579_abnormal_nail_morphology2.33790683
18MP0005083_abnormal_biliary_tract2.29999430
19MP0002118_abnormal_lipid_homeostasis2.11452463
20MP0005257_abnormal_intraocular_pressure2.10696879
21MP0000747_muscle_weakness2.10579131
22MP0003195_calcinosis2.05270699
23MP0008438_abnormal_cutaneous_collagen2.04714817
24MP0004233_abnormal_muscle_weight2.04046816
25MP0005174_abnormal_tail_pigmentation1.97236020
26MP0001666_abnormal_nutrient_absorption1.96084937
27MP0004019_abnormal_vitamin_homeostasis1.95093767
28MP0003950_abnormal_plasma_membrane1.90960180
29MP0000609_abnormal_liver_physiology1.85291526
30MP0003191_abnormal_cellular_cholesterol1.84035793
31MP0003698_abnormal_male_reproductive1.84027909
32MP0005275_abnormal_skin_tensile1.81510537
33MP0003329_amyloid_beta_deposits1.74524773
34MP0005330_cardiomyopathy1.73800558
35MP0001764_abnormal_homeostasis1.72095856
36MP0001958_emphysema1.71105992
37MP0005584_abnormal_enzyme/coenzyme_acti1.70319989
38MP0005319_abnormal_enzyme/_coenzyme1.65979867
39MP0000749_muscle_degeneration1.64983600
40MP0005670_abnormal_white_adipose1.63032739
41MP0004084_abnormal_cardiac_muscle1.61693201
42MP0003566_abnormal_cell_adhesion1.58111949
43MP0000604_amyloidosis1.55806639
44MP0002877_abnormal_melanocyte_morpholog1.54096035
45MP0002060_abnormal_skin_morphology1.53413228
46MP0001929_abnormal_gametogenesis1.51734496
47MP0003879_abnormal_hair_cell1.50690530
48MP0004087_abnormal_muscle_fiber1.50425714
49MP0000003_abnormal_adipose_tissue1.47271261
50MP0005076_abnormal_cell_differentiation1.43896736
51MP0000015_abnormal_ear_pigmentation1.42274530
52MP0000013_abnormal_adipose_tissue1.41810109
53MP0004130_abnormal_muscle_cell1.39458803
54MP0000750_abnormal_muscle_regeneration1.34927938
55MP0010368_abnormal_lymphatic_system1.31263126
56MP0002822_catalepsy1.31259367
57MP0000759_abnormal_skeletal_muscle1.31140771
58MP0005058_abnormal_lysosome_morphology1.31139746
59MP0003656_abnormal_erythrocyte_physiolo1.27592409
60MP0003868_abnormal_feces_composition1.26483603
61MP0005647_abnormal_sex_gland1.25411558
62MP0009697_abnormal_copulation1.25145580
63MP0002876_abnormal_thyroid_physiology1.23399699
64MP0005535_abnormal_body_temperature1.23096964
65MP0003453_abnormal_keratinocyte_physiol1.23022940
66MP0003011_delayed_dark_adaptation1.22388447
67MP0002896_abnormal_bone_mineralization1.21742875
68MP0010234_abnormal_vibrissa_follicle1.19715037
69MP0003091_abnormal_cell_migration1.19072938
70MP0000467_abnormal_esophagus_morphology1.18004042
71MP0006036_abnormal_mitochondrial_physio1.17638905
72MP0004185_abnormal_adipocyte_glucose1.16999731
73MP0004381_abnormal_hair_follicle1.16621822
74MP0001348_abnormal_lacrimal_gland1.14925860
75MP0001502_abnormal_circadian_rhythm1.12914394
76MP0004272_abnormal_basement_membrane1.10755725
77MP0003690_abnormal_glial_cell1.07669510
78MP0001986_abnormal_taste_sensitivity1.07321002
79MP0005023_abnormal_wound_healing1.04954106
80MP0002971_abnormal_brown_adipose1.03755878
81MP0004215_abnormal_myocardial_fiber1.03722639
82MP0002161_abnormal_fertility/fecundity1.03136244
83MP0005636_abnormal_mineral_homeostasis1.02190063
84MP0009643_abnormal_urine_homeostasis1.00592745
85MP0004270_analgesia0.99532812
86MP0005501_abnormal_skin_physiology0.98721446
87MP0002138_abnormal_hepatobiliary_system0.96551121
88MP0001765_abnormal_ion_homeostasis0.95934206
89MP0003646_muscle_fatigue0.94112651
90MP0000733_abnormal_muscle_development0.93979031
91MP0002837_dystrophic_cardiac_calcinosis0.93905597
92MP0000383_abnormal_hair_follicle0.93398682
93MP0006138_congestive_heart_failure0.90054711
94MP0000569_abnormal_digit_pigmentation0.89940788
95MP0008569_lethality_at_weaning0.89146822
96MP0010678_abnormal_skin_adnexa0.88590299
97MP0003045_fibrosis0.87836906
98MP0002078_abnormal_glucose_homeostasis0.87685688
99MP0000598_abnormal_liver_morphology0.87046517
100MP0010771_integument_phenotype0.86560332
101MP0004859_abnormal_synaptic_plasticity0.86144527
102MP0001661_extended_life_span0.84482993
103MP0005620_abnormal_muscle_contractility0.84067280
104MP0002160_abnormal_reproductive_system0.82774812
105MP0004145_abnormal_muscle_electrophysio0.82772560
106MP0002106_abnormal_muscle_physiology0.82447077
107MP0005334_abnormal_fat_pad0.82255021
108MP0008877_abnormal_DNA_methylation0.81458139
109MP0001984_abnormal_olfaction0.81280343
110MP0005375_adipose_tissue_phenotype0.80985048
111MP0003941_abnormal_skin_development0.80889861
112MP0002735_abnormal_chemical_nociception0.80833909
113MP0003186_abnormal_redox_activity0.80325121
114MP0005451_abnormal_body_composition0.80186149
115MP0003183_abnormal_peptide_metabolism0.78769562
116MP0008874_decreased_physiological_sensi0.78396424
117MP0006035_abnormal_mitochondrial_morpho0.78388356
118MP0005666_abnormal_adipose_tissue0.78172998
119MP0003633_abnormal_nervous_system0.78084324
120MP0001968_abnormal_touch/_nociception0.77058847
121MP0000762_abnormal_tongue_morphology0.76972095
122MP0009642_abnormal_blood_homeostasis0.76935545
123MP0005376_homeostasis/metabolism_phenot0.76600531
124MP0010630_abnormal_cardiac_muscle0.75915917
125MP0004043_abnormal_pH_regulation0.74121320
126MP0005266_abnormal_metabolism0.73926733
127MP0009046_muscle_twitch0.73428534
128MP0000377_abnormal_hair_follicle0.73373741
129MP0005408_hypopigmentation0.72757842
130MP0009780_abnormal_chondrocyte_physiolo0.71920282
131MP0004484_altered_response_of0.70217508
132MP0002089_abnormal_postnatal_growth/wei0.70109160
133MP0004885_abnormal_endolymph0.68042316
134MP0005369_muscle_phenotype0.67986505
135MP0000371_diluted_coat_color0.67588554
136MP0009763_increased_sensitivity_to0.66920746
137MP0009384_cardiac_valve_regurgitation0.66110367
138MP0000920_abnormal_myelination0.64761654
139MP0000367_abnormal_coat/_hair0.64500322
140MP0005448_abnormal_energy_balance0.64170591
141MP0004264_abnormal_extraembryonic_tissu0.63819436
142MP0002909_abnormal_adrenal_gland0.61953538
143MP0003631_nervous_system_phenotype0.61753752
144MP0008469_abnormal_protein_level0.59982805
145MP0003953_abnormal_hormone_level0.59423698
146MP0002269_muscular_atrophy0.59216493
147MP0002736_abnormal_nociception_after0.58651022
148MP0003075_altered_response_to0.58300011
149MP0009115_abnormal_fat_cell0.58243835
150MP0004036_abnormal_muscle_relaxation0.57650030
151MP0002796_impaired_skin_barrier0.57496771
152MP0008872_abnormal_physiological_respon0.56187800
153MP0000639_abnormal_adrenal_gland0.55676726
154MP0009764_decreased_sensitivity_to0.55671630
155MP0002210_abnormal_sex_determination0.55386774
156MP0002272_abnormal_nervous_system0.54464126
157MP0001145_abnormal_male_reproductive0.54012525
158MP0009745_abnormal_behavioral_response0.53833579
159MP0002229_neurodegeneration0.53531386
160MP0003635_abnormal_synaptic_transmissio0.53327922
161MP0000653_abnormal_sex_gland0.53150098
162MP0002928_abnormal_bile_duct0.52434771
163MP0002064_seizures0.51551574
164MP0008961_abnormal_basal_metabolism0.51058277
165MP0001756_abnormal_urination0.48442674
166MP0001501_abnormal_sleep_pattern0.47893969
167MP0002063_abnormal_learning/memory/cond0.47490183
168MP0003632_abnormal_nervous_system0.47484027

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.66130151
2Intrahepatic cholestasis (HP:0001406)5.61585468
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.49910488
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.08255918
5Absent/shortened dynein arms (HP:0200106)5.08255918
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.07788797
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.80365610
8Xanthomatosis (HP:0000991)4.79034143
9Hypobetalipoproteinemia (HP:0003563)4.72657534
10Prolonged partial thromboplastin time (HP:0003645)4.68344646
11Complement deficiency (HP:0004431)4.41251064
12Hyperlipoproteinemia (HP:0010980)4.10732166
13Hypolipoproteinemia (HP:0010981)3.77349290
14Hyperammonemia (HP:0001987)3.71307418
15Ketosis (HP:0001946)3.69819371
16Epidermoid cyst (HP:0200040)3.66430144
17Hypoalphalipoproteinemia (HP:0003233)3.48984046
18Hyperglycinemia (HP:0002154)3.45269844
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.43225796
20Abnormal respiratory motile cilium physiology (HP:0012261)3.40684358
21Popliteal pterygium (HP:0009756)3.40431427
22Abnormal gallbladder physiology (HP:0012438)3.36147679
23Cholecystitis (HP:0001082)3.36147679
24Joint hemorrhage (HP:0005261)3.35833297
25Abnormality of the common coagulation pathway (HP:0010990)3.35145572
26Thin bony cortex (HP:0002753)3.30270731
27Infertility (HP:0000789)3.27955707
28Akinesia (HP:0002304)3.26253497
29Hypercholesterolemia (HP:0003124)3.25732362
30Hyperglycinuria (HP:0003108)3.23658474
31Abnormality of serine family amino acid metabolism (HP:0010894)3.19581163
32Abnormality of glycine metabolism (HP:0010895)3.19581163
33Fat malabsorption (HP:0002630)3.17331232
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.16519372
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.15588223
36Atrioventricular block (HP:0001678)3.14852749
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.14671875
38Abnormality of methionine metabolism (HP:0010901)3.14461404
39Exercise-induced myalgia (HP:0003738)3.11395924
40Abnormality of complement system (HP:0005339)3.10442292
41Abnormal respiratory epithelium morphology (HP:0012253)3.06080886
42Abnormal respiratory motile cilium morphology (HP:0005938)3.06080886
43Ulnar bowing (HP:0003031)3.03805297
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.98538384
45Aplasia of the musculature (HP:0100854)2.97142338
46Abnormality of the lower motor neuron (HP:0002366)2.95702190
47Atrophic scars (HP:0001075)2.92129624
48Rhinitis (HP:0012384)2.89551249
49Conjugated hyperbilirubinemia (HP:0002908)2.89192671
50Abnormality of the intrinsic pathway (HP:0010989)2.87199822
51Abnormal atrioventricular conduction (HP:0005150)2.78717404
52Fetal akinesia sequence (HP:0001989)2.78576448
53Abnormality of fatty-acid metabolism (HP:0004359)2.78378980
54Testicular atrophy (HP:0000029)2.78098056
55Asymmetric septal hypertrophy (HP:0001670)2.77007827
56Hyporeflexia of lower limbs (HP:0002600)2.74104778
57Heart block (HP:0012722)2.73859698
58Hyperbilirubinemia (HP:0002904)2.73784884
59Lip pit (HP:0100267)2.72474531
60Hypoglycemic coma (HP:0001325)2.72116760
61Type 1 muscle fiber predominance (HP:0003803)2.67634540
62Nasal polyposis (HP:0100582)2.67430215
63Choroideremia (HP:0001139)2.62527478
64Gout (HP:0001997)2.58147841
65Vascular calcification (HP:0004934)2.57485706
66Chronic bronchitis (HP:0004469)2.56646708
67Ketoacidosis (HP:0001993)2.52297211
68Protrusio acetabuli (HP:0003179)2.50400199
69Abnormal ciliary motility (HP:0012262)2.50237583
70Spastic tetraparesis (HP:0001285)2.49421573
71Muscle fiber inclusion bodies (HP:0100299)2.48879431
72Abnormality of nail color (HP:0100643)2.48850390
73Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.47266158
74Bundle branch block (HP:0011710)2.41594846
75Spontaneous abortion (HP:0005268)2.40910217
76Acanthocytosis (HP:0001927)2.40565175
77Abnormality of pyrimidine metabolism (HP:0004353)2.39778798
78Abnormality of nucleobase metabolism (HP:0010932)2.39236919
79Abnormality of purine metabolism (HP:0004352)2.38965980
80Nemaline bodies (HP:0003798)2.36461894
81Steatorrhea (HP:0002570)2.28113889
82Abnormal gallbladder morphology (HP:0012437)2.27246161
83Abnormality of serum amino acid levels (HP:0003112)2.23756257
84Cholelithiasis (HP:0001081)2.22323899
85Distal lower limb muscle weakness (HP:0009053)2.21465628
86Hyperkalemia (HP:0002153)2.21140859
87Dysmetric saccades (HP:0000641)2.20215994
88Delayed CNS myelination (HP:0002188)2.19677695
89Turricephaly (HP:0000262)2.19372411
90Myotonia (HP:0002486)2.18755394
91Cardiovascular calcification (HP:0011915)2.18597329
92Facial diplegia (HP:0001349)2.18457116
93Hemorrhage of the eye (HP:0011885)2.18330121
94Abnormality of the costochondral junction (HP:0000919)2.16019315
95Upper motor neuron abnormality (HP:0002127)2.15673360
96Metabolic acidosis (HP:0001942)2.13994570
97Abnormality of the nasal mucosa (HP:0000433)2.13426146
98Right ventricular cardiomyopathy (HP:0011663)2.13219267
99Vascular tortuosity (HP:0004948)2.13180072
100Mesangial abnormality (HP:0001966)2.12328220
101Arterial tortuosity (HP:0005116)2.10550923
102Coronal craniosynostosis (HP:0004440)2.10206926
103Malnutrition (HP:0004395)2.09445051
104Myocardial infarction (HP:0001658)2.09277059
105Neurofibrillary tangles (HP:0002185)2.08991515
106Milia (HP:0001056)2.08813284
107Urinary glycosaminoglycan excretion (HP:0003541)2.05877120
108Mucopolysacchariduria (HP:0008155)2.05877120
109Skin nodule (HP:0200036)2.05152230
110Pterygium (HP:0001059)2.04934373
111Attenuation of retinal blood vessels (HP:0007843)2.04351252
112Abnormality of the neuromuscular junction (HP:0003398)2.03548687
113Fatigable weakness (HP:0003473)2.03548687
114Dicarboxylic aciduria (HP:0003215)2.02327479
115Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02327479
116Annular pancreas (HP:0001734)2.01908341
117Ulnar deviation of the wrist (HP:0003049)2.01697222
118Amyloidosis (HP:0011034)2.00829297
119Malignant hyperthermia (HP:0002047)1.99937745
120Hepatocellular carcinoma (HP:0001402)1.97586575
121Irritability (HP:0000737)1.96686508
122Hypochromic microcytic anemia (HP:0004840)1.94571768
123Hyperventilation (HP:0002883)1.94276041
124Abnormality of polysaccharide metabolism (HP:0011012)1.92873527
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92873527
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92873527
127Impaired proprioception (HP:0010831)1.92515111
128Short chin (HP:0000331)1.92091532
129Onycholysis (HP:0001806)1.91000800
130Lethargy (HP:0001254)1.90812478
131Atrial fibrillation (HP:0005110)1.90722524
132Pancreatitis (HP:0001733)1.89926480
133Upper limb amyotrophy (HP:0009129)1.89849397
134Distal upper limb amyotrophy (HP:0007149)1.89849397
135Death in childhood (HP:0003819)1.89190295
136Cervical subluxation (HP:0003308)1.88444700
137Hyperuricemia (HP:0002149)1.88082257
138Increased purine levels (HP:0004368)1.88082257
139Neonatal onset (HP:0003623)1.87274605
140Increased connective tissue (HP:0009025)1.87136488
141Abnormality of the gallbladder (HP:0005264)1.86262628
142Status epilepticus (HP:0002133)1.85308305
143Myopathic facies (HP:0002058)1.85301086
144Myoglobinuria (HP:0002913)1.84912954
145Tetraplegia (HP:0002445)1.84821434
146Poikiloderma (HP:0001029)1.84300665
147Sensorimotor neuropathy (HP:0007141)1.82948092
148Cerebral inclusion bodies (HP:0100314)1.82543802
149Diminished movement (HP:0002374)1.82287503
150Hyperinsulinemic hypoglycemia (HP:0000825)1.81555225
151Brushfield spots (HP:0001088)1.78459780
152Systemic lupus erythematosus (HP:0002725)1.78317461
153Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77780059
154Premature rupture of membranes (HP:0001788)1.76954491
155Abnormality of vision evoked potentials (HP:0000649)1.75727915
156Hyperacusis (HP:0010780)1.75399795
157Bradycardia (HP:0001662)1.74213339
158Insomnia (HP:0100785)1.74020634
159Intention tremor (HP:0002080)1.74016939
160Fragile skin (HP:0001030)1.73627038
161Aortic aneurysm (HP:0004942)1.72869367
162Advanced eruption of teeth (HP:0006288)1.71168276
163Hypophosphatemic rickets (HP:0004912)1.70660879
164Primary atrial arrhythmia (HP:0001692)1.69854147
165Bladder diverticulum (HP:0000015)1.69812101
166Poikilocytosis (HP:0004447)1.68672242
167Mildly elevated creatine phosphokinase (HP:0008180)1.68368358
168Protuberant abdomen (HP:0001538)1.68178193
169Wormian bones (HP:0002645)1.67811227
170Amniotic constriction ring (HP:0009775)1.66237916
171Abnormality of placental membranes (HP:0011409)1.66237916
172Cerebral edema (HP:0002181)1.66175691
173Hypopigmentation of the fundus (HP:0007894)1.66152672
174Recurrent gram-negative bacterial infections (HP:0005420)1.65210954
175Mitral stenosis (HP:0001718)1.65026806
176Round ear (HP:0100830)1.64751876
177Dyschromatopsia (HP:0007641)1.64667382
178Delayed epiphyseal ossification (HP:0002663)1.64347253
179EMG: myopathic abnormalities (HP:0003458)1.64066352
180Enlarged epiphyses (HP:0010580)1.63927348
181Spinal rigidity (HP:0003306)1.62755831
182Sparse lateral eyebrow (HP:0005338)1.62071046
183Sudden death (HP:0001699)1.61644062
184Cerebral aneurysm (HP:0004944)1.59009492
185Natal tooth (HP:0000695)1.58977452
186Supraventricular tachycardia (HP:0004755)1.57891219
187Hand muscle atrophy (HP:0009130)1.57175714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.20616899
2PDK46.20616899
3PRKD33.64253295
4PDK23.62165804
5CDK123.49936504
6TESK13.07881686
7BCKDK2.87016216
8ICK2.59111066
9TTN2.17171565
10EEF2K2.07386739
11MAP2K42.00413447
12MUSK1.97860144
13PTK2B1.90972730
14STK391.90197993
15TAOK31.90128931
16STK381.82200895
17OBSCN1.81251988
18WNK41.75576971
19SCYL21.71481469
20MARK11.71083941
21PINK11.70487540
22MST1R1.69959377
23LATS21.68434154
24PIK3CG1.64378091
25TRPM71.56791190
26FGFR41.51815137
27PDK11.46988257
28DAPK21.46227663
29NEK61.42606672
30PDGFRA1.40697369
31MTOR1.28113969
32PDPK11.24136983
33MAP2K11.20381665
34SIK11.19243432
35DDR21.19052265
36ERN11.15126453
37EPHA41.14526077
38NTRK31.13702706
39FRK1.12248343
40SGK31.11686254
41MINK11.09307971
42TRIB31.08643824
43SGK21.06476203
44CAMKK11.05245059
45PBK1.03298949
46SGK2231.01546769
47SGK4941.01546769
48MAP2K61.00126587
49NTRK10.96899394
50MAP3K40.95929202
51BRD40.94256571
52WNK10.92591702
53EPHA20.91652544
54INSRR0.89798748
55CAMK1G0.88380372
56PTK20.86804368
57PRPF4B0.85570722
58RET0.83432158
59PNCK0.82321257
60PIK3CA0.80366046
61ACVR1B0.79466700
62MAP3K70.78460015
63LATS10.77513775
64PRKAA10.77510785
65MAPK150.73577023
66EPHB10.72438154
67ERBB40.72046837
68PDGFRB0.71195146
69FGFR20.71090756
70PRKCG0.70084087
71MYLK0.69579091
72AKT30.69439432
73NEK90.69288885
74RIPK40.65134210
75RPS6KB10.64300685
76PRKD10.64163117
77MAP2K70.63977527
78LMTK20.63424414
79MAPK110.62989938
80MAPK40.62075891
81JAK20.61993618
82RAF10.61859699
83PRKCZ0.60303894
84JAK10.60215250
85CAMK2G0.60152936
86MELK0.59817272
87OXSR10.59475108
88FER0.58485937
89RPS6KL10.58260376
90RPS6KC10.58260376
91PRKD20.57715483
92AKT20.57418964
93PRKCQ0.56789728
94PAK60.56323741
95MAPKAPK50.56079449
96MAP3K20.56053240
97PRKACG0.55458193
98MET0.54400362
99CAMK10.54122136
100SGK10.53519804
101CAMK2B0.52399375
102MAP3K90.52348667
103MAPK100.51683060
104PAK20.51662939
105MAP3K30.51619741
106RPS6KA60.50391495
107KSR20.50280531
108BMPR20.49510839
109FLT30.49298503
110PRKAA20.47829412
111PKN20.47484619
112DAPK10.46692295
113ROCK10.46378918
114MAP2K30.44822420
115PIM20.43370198
116MAP3K130.43198712
117GRK50.42945792
118BRAF0.41891703
119BMX0.41540491
120CDK50.41445919
121GSK3A0.40780040
122EIF2AK10.40761922
123MAP3K10.40171877
124NTRK20.39727085
125PRKCH0.39390980
126MARK20.38730265
127RPS6KA20.38050801
128FGFR30.37506182
129RIPK10.37257571
130MAP3K60.36386650
131CAMK2A0.35415356
132DYRK1B0.34447465
133STK38L0.33904654
134TYK20.33157574
135ARAF0.32354307
136MAP3K50.32181785
137STK110.31921805
138ABL20.31507454
139PTK60.30705009
140MAPK120.30401708
141CAMK1D0.29778503
142STK30.29714402
143PHKG20.29173833
144PHKG10.29173833
145MAPKAPK30.29171277
146RPS6KA30.28980137

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93808880
2Nitrogen metabolism_Homo sapiens_hsa009103.61531959
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12769383
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74230787
5Arginine biosynthesis_Homo sapiens_hsa002202.73016163
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55284026
7Propanoate metabolism_Homo sapiens_hsa006402.51201957
8Fatty acid degradation_Homo sapiens_hsa000712.46815648
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.45215918
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45156835
11Complement and coagulation cascades_Homo sapiens_hsa046102.20649516
12Tryptophan metabolism_Homo sapiens_hsa003802.19103290
13PPAR signaling pathway_Homo sapiens_hsa033202.11573000
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.09667783
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08685075
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04254056
17Pyruvate metabolism_Homo sapiens_hsa006202.00434620
18Fatty acid metabolism_Homo sapiens_hsa012121.99265604
19Vitamin B6 metabolism_Homo sapiens_hsa007501.95274482
20Butanoate metabolism_Homo sapiens_hsa006501.89352137
21Peroxisome_Homo sapiens_hsa041461.86706441
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84879234
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68509775
24Dilated cardiomyopathy_Homo sapiens_hsa054141.64826120
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64174399
26Bile secretion_Homo sapiens_hsa049761.63041530
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62572482
28Chemical carcinogenesis_Homo sapiens_hsa052041.60691329
29ECM-receptor interaction_Homo sapiens_hsa045121.57612249
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.52019015
31Histidine metabolism_Homo sapiens_hsa003401.50040765
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48453309
33Fatty acid biosynthesis_Homo sapiens_hsa000611.47656071
34beta-Alanine metabolism_Homo sapiens_hsa004101.45688578
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45643927
36Selenocompound metabolism_Homo sapiens_hsa004501.45450613
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44734049
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.44203286
39Circadian rhythm_Homo sapiens_hsa047101.41842428
40Sulfur metabolism_Homo sapiens_hsa009201.41411600
41Carbon metabolism_Homo sapiens_hsa012001.38255844
42Starch and sucrose metabolism_Homo sapiens_hsa005001.37626769
43ABC transporters_Homo sapiens_hsa020101.32523394
44Caffeine metabolism_Homo sapiens_hsa002321.31862943
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.31535231
46Retinol metabolism_Homo sapiens_hsa008301.30359243
47Fatty acid elongation_Homo sapiens_hsa000621.25525339
48Sphingolipid metabolism_Homo sapiens_hsa006001.25235219
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24082091
50Fat digestion and absorption_Homo sapiens_hsa049751.23501795
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.23373963
52Inositol phosphate metabolism_Homo sapiens_hsa005621.20175233
53Glycerolipid metabolism_Homo sapiens_hsa005611.19989233
54Phenylalanine metabolism_Homo sapiens_hsa003601.18925322
55Biosynthesis of amino acids_Homo sapiens_hsa012301.18039603
56Tyrosine metabolism_Homo sapiens_hsa003501.15790467
57Staphylococcus aureus infection_Homo sapiens_hsa051501.15498493
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13550824
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13128380
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11221087
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10912490
62mTOR signaling pathway_Homo sapiens_hsa041501.10378384
63Focal adhesion_Homo sapiens_hsa045101.08778928
64Gastric acid secretion_Homo sapiens_hsa049711.08622341
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08443743
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06589097
67Calcium signaling pathway_Homo sapiens_hsa040201.05444187
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98974031
69Estrogen signaling pathway_Homo sapiens_hsa049150.97637662
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96143744
71Pentose phosphate pathway_Homo sapiens_hsa000300.91914689
72Ovarian steroidogenesis_Homo sapiens_hsa049130.91840505
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89900946
74Other glycan degradation_Homo sapiens_hsa005110.89733941
75Melanogenesis_Homo sapiens_hsa049160.86620086
76Glioma_Homo sapiens_hsa052140.86070770
77Circadian entrainment_Homo sapiens_hsa047130.85637793
78Glutamatergic synapse_Homo sapiens_hsa047240.84368568
79Oxytocin signaling pathway_Homo sapiens_hsa049210.84034513
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.80468689
81Vitamin digestion and absorption_Homo sapiens_hsa049770.79884059
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79771650
83GnRH signaling pathway_Homo sapiens_hsa049120.79733035
84Glucagon signaling pathway_Homo sapiens_hsa049220.78704829
85ErbB signaling pathway_Homo sapiens_hsa040120.78485659
86Lysosome_Homo sapiens_hsa041420.78234444
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77601805
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75637760
89Endometrial cancer_Homo sapiens_hsa052130.74853485
90Steroid biosynthesis_Homo sapiens_hsa001000.71845707
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71811342
92Gap junction_Homo sapiens_hsa045400.71704433
93Cholinergic synapse_Homo sapiens_hsa047250.69525788
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.69525354
95VEGF signaling pathway_Homo sapiens_hsa043700.69153192
96Nicotine addiction_Homo sapiens_hsa050330.69147254
97Pancreatic secretion_Homo sapiens_hsa049720.69141275
98Proteoglycans in cancer_Homo sapiens_hsa052050.68533993
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.65849547
100cAMP signaling pathway_Homo sapiens_hsa040240.65679299
101Glutathione metabolism_Homo sapiens_hsa004800.65489064
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.65174985
103Cocaine addiction_Homo sapiens_hsa050300.63557557
104Bladder cancer_Homo sapiens_hsa052190.62637852
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62087929
106Arginine and proline metabolism_Homo sapiens_hsa003300.61794280
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61699409
108Fructose and mannose metabolism_Homo sapiens_hsa000510.61696896
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61261908
110Folate biosynthesis_Homo sapiens_hsa007900.59650160
111Adherens junction_Homo sapiens_hsa045200.57875842
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57826739
113Morphine addiction_Homo sapiens_hsa050320.57431898
114Small cell lung cancer_Homo sapiens_hsa052220.56398039
115Lysine degradation_Homo sapiens_hsa003100.55598674
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.55013803
117Non-small cell lung cancer_Homo sapiens_hsa052230.54977080
118Taste transduction_Homo sapiens_hsa047420.54806235
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53784546
120Endocytosis_Homo sapiens_hsa041440.51960345
121Linoleic acid metabolism_Homo sapiens_hsa005910.48601589
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.47296338
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46350931
124Galactose metabolism_Homo sapiens_hsa000520.43988397
125Metabolic pathways_Homo sapiens_hsa011000.42748326
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37369835
127Insulin resistance_Homo sapiens_hsa049310.37106563
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.33695079
129Sulfur relay system_Homo sapiens_hsa041220.31823367
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.30489846
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29560979
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28303025
133AMPK signaling pathway_Homo sapiens_hsa041520.24338939
134Dorso-ventral axis formation_Homo sapiens_hsa043200.24003520
135Amphetamine addiction_Homo sapiens_hsa050310.23156941
136Thyroid hormone synthesis_Homo sapiens_hsa049180.22717816
137Synaptic vesicle cycle_Homo sapiens_hsa047210.21516139
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20280913
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19013024
140Type II diabetes mellitus_Homo sapiens_hsa049300.17632544
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.16874819
142Insulin signaling pathway_Homo sapiens_hsa049100.15527083
143Insulin secretion_Homo sapiens_hsa049110.13963644
144Prion diseases_Homo sapiens_hsa050200.13353157
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.12998624
146Renin secretion_Homo sapiens_hsa049240.11484320
147Long-term potentiation_Homo sapiens_hsa047200.07982478
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.07335414
149GABAergic synapse_Homo sapiens_hsa047270.03425415
150Salivary secretion_Homo sapiens_hsa049700.02925315
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.02601469
152Mineral absorption_Homo sapiens_hsa049780.02391246

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