ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	motile cilium assembly (GO:0044458)	8.51386281
2	axonemal dynein complex assembly (GO:0070286)	8.39623057
3	epithelial cilium movement (GO:0003351)	6.85179291
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.84390733
5	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	6.79960250
6	cilium movement (GO:0003341)	6.54587718
7	regulation of phosphoprotein phosphatase activity (GO:0043666)	6.41666449
8	cilium or flagellum-dependent cell motility (GO:0001539)	6.19851087
9	regulation of cilium movement (GO:0003352)	6.05626515
10	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	6.02559571
11	positive regulation of catecholamine secretion (GO:0033605)	5.45950660
12	regulation of autophagic vacuole assembly (GO:2000785)	5.29399769
13	DNA double-strand break processing (GO:0000729)	5.22205710
14	regulation of oxidative stress-induced neuron death (GO:1903203)	5.06452444
15	ventricular system development (GO:0021591)	4.99728574
16	activation of protein kinase B activity (GO:0032148)	4.71405420
17	spermatid development (GO:0007286)	4.42911779
18	coenzyme catabolic process (GO:0009109)	4.40884939
19	sperm motility (GO:0030317)	4.38164876
20	otic vesicle formation (GO:0030916)	4.35941016
21	protein localization to cilium (GO:0061512)	4.33103388
22	regulation of vacuole organization (GO:0044088)	4.18904485
23	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.85732645
24	male sex determination (GO:0030238)	3.84667139
25	intraciliary transport (GO:0042073)	3.80787896
26	mitochondrion degradation (GO:0000422)	3.75694446
27	multicellular organism reproduction (GO:0032504)	3.74497236
28	histone H3-K36 demethylation (GO:0070544)	3.68995167
29	binding of sperm to zona pellucida (GO:0007339)	3.67427830
30	positive regulation of protein homodimerization activity (GO:0090073)	3.54872011
31	microtubule depolymerization (GO:0007019)	3.53456645
32	mRNA cleavage (GO:0006379)	3.45574945
33	cilium organization (GO:0044782)	3.45558344
34	cilium assembly (GO:0042384)	3.44039045
35	cranial nerve morphogenesis (GO:0021602)	3.43520235
36	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.42856668
37	muscle hypertrophy in response to stress (GO:0003299)	3.42856668
38	cardiac muscle adaptation (GO:0014887)	3.42856668
39	acrosome reaction (GO:0007340)	3.40620336
40	androgen biosynthetic process (GO:0006702)	3.35959104
41	cellular response to zinc ion (GO:0071294)	3.32750048
42	tongue development (GO:0043586)	3.29138047
43	regulation of cardiac muscle cell apoptotic process (GO:0010665)	3.25910087
44	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.25437453
45	membrane repolarization (GO:0086009)	3.25415300
46	cGMP-mediated signaling (GO:0019934)	3.23631261
47	relaxation of smooth muscle (GO:0044557)	3.22627600
48	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.20730430
49	microtubule severing (GO:0051013)	3.19836027
50	extracellular fibril organization (GO:0043206)	3.19635398
51	barbed-end actin filament capping (GO:0051016)	3.18637774
52	single fertilization (GO:0007338)	3.17599218
53	oligosaccharide biosynthetic process (GO:0009312)	3.17344589
54	centriole assembly (GO:0098534)	3.12366552
55	regulation of cofactor metabolic process (GO:0051193)	3.10920400
56	regulation of coenzyme metabolic process (GO:0051196)	3.10920400
57	potassium ion export (GO:0071435)	3.10913196
58	nucleosome disassembly (GO:0006337)	3.10892725
59	protein-DNA complex disassembly (GO:0032986)	3.10892725
60	TOR signaling (GO:0031929)	3.10472877
61	sperm-egg recognition (GO:0035036)	3.08551595
62	organic cation transport (GO:0015695)	3.08253601
63	positive regulation of glycolytic process (GO:0045821)	3.07069658
64	histone exchange (GO:0043486)	3.04147980
65	regulation of microtubule-based movement (GO:0060632)	3.02923734
66	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	3.01434641
67	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.00225676
68	male meiosis (GO:0007140)	2.99176234
69	axoneme assembly (GO:0035082)	2.95038084
70	protein polymerization (GO:0051258)	2.93950509
71	regulation of oxidative phosphorylation (GO:0002082)	2.91581015
72	cilium morphogenesis (GO:0060271)	2.89343972
73	regulation of cellular respiration (GO:0043457)	2.85377720
74	cell-cell recognition (GO:0009988)	2.84666061
75	regulation of phosphatase activity (GO:0010921)	2.84622375
76	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	2.83782244
77	regulation of ARF GTPase activity (GO:0032312)	2.81146466
78	cardiac muscle hypertrophy (GO:0003300)	2.80896127
79	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.79050143
80	cellular component assembly involved in morphogenesis (GO:0010927)	2.77130827
81	glutamine family amino acid catabolic process (GO:0009065)	2.74725739
82	regulation of dopamine secretion (GO:0014059)	2.73173319
83	positive regulation of male gonad development (GO:2000020)	2.72862769
84	negative regulation of microtubule polymerization (GO:0031115)	2.71920670
85	negative regulation of circadian rhythm (GO:0042754)	2.71759101
86	positive regulation of protein kinase C signaling (GO:0090037)	2.70012969
87	microtubule polymerization or depolymerization (GO:0031109)	2.69194697
88	paraxial mesoderm development (GO:0048339)	2.64621402
89	striated muscle hypertrophy (GO:0014897)	2.64152197
90	radial glial cell differentiation (GO:0060019)	2.63855637
91	regulation of striated muscle cell apoptotic process (GO:0010662)	2.63677542
92	polyamine metabolic process (GO:0006595)	2.62471215
93	potassium ion import (GO:0010107)	2.61596486
94	regulation of protein kinase A signaling (GO:0010738)	2.60644821
95	heterochromatin organization (GO:0070828)	2.59460095
96	epithelial cell differentiation involved in kidney development (GO:0035850)	2.55151219
97	negative regulation of response to reactive oxygen species (GO:1901032)	2.55101358
98	regulation of protein kinase C signaling (GO:0090036)	2.53584050
99	negative regulation of DNA binding (GO:0043392)	2.53407426
100	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.53122598

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.73256670
2	IGF1R_20145208_ChIP-Seq_DFB_Human	5.81522746
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.65303819
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	5.45561016
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.55320917
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.50541236
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.44066463
8	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.88495752
9	FUS_26573619_Chip-Seq_HEK293_Human	2.76265226
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.56282669
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.49555417
12	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.28298069
13	AR_21572438_ChIP-Seq_LNCaP_Human	1.93424381
14	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.89367326
15	CBP_20019798_ChIP-Seq_JUKART_Human	1.89367326
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.88729509
17	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.87974436
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.85640653
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85640653
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.83750806
21	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.74674819
22	EWS_26573619_Chip-Seq_HEK293_Human	1.73142364
23	P300_19829295_ChIP-Seq_ESCs_Human	1.63639171
24	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.55978241
25	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.54142779
26	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48107280
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.46687075
28	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.45958248
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.44344002
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.36657119
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35652449
32	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.34006137
33	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.31140316
34	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30307223
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26804782
36	TBL1_22424771_ChIP-Seq_293T_Human	1.26758346
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25957565
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.24719448
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.22040642
40	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.18744721
41	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18626177
42	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13236424
43	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.13087186
44	MYC_19829295_ChIP-Seq_ESCs_Human	1.12747596
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11653388
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11026228
47	RXR_22108803_ChIP-Seq_LS180_Human	1.10162419
48	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.09685949
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.08977047
50	CBP_21632823_ChIP-Seq_H3396_Human	1.07407179
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07169899
52	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.03949439
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03925910
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03717338
55	ERA_21632823_ChIP-Seq_H3396_Human	1.02471967
56	NFYB_21822215_ChIP-Seq_K562_Human	1.01724028
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.00377546
58	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99563760
59	VDR_22108803_ChIP-Seq_LS180_Human	0.99441920
60	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.98527398
61	KDM5A_27292631_Chip-Seq_BREAST_Human	0.98132334
62	STAT3_23295773_ChIP-Seq_U87_Human	0.96920363
63	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96222927
64	AR_25329375_ChIP-Seq_VCAP_Human	0.95762355
65	AHR_22903824_ChIP-Seq_MCF-7_Human	0.94674896
66	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.94512458
67	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.93925420
68	PHF8_20622853_ChIP-Seq_HELA_Human	0.93908722
69	NFYA_21822215_ChIP-Seq_K562_Human	0.93439299
70	SPI1_20517297_ChIP-Seq_HL60_Human	0.93412353
71	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.93335841
72	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.92752641
73	FOXP3_21729870_ChIP-Seq_TREG_Human	0.92664917
74	OCT4_20526341_ChIP-Seq_ESCs_Human	0.92135019
75	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.91655038
76	RAC3_21632823_ChIP-Seq_H3396_Human	0.91045410
77	CIITA_25753668_ChIP-Seq_RAJI_Human	0.90087449
78	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.89947993
79	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89702086
80	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.88982037
81	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.87565855
82	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.86839756
83	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.86242720
84	ELK1_19687146_ChIP-ChIP_HELA_Human	0.86212894
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.86003094
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.85480441
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.84291769
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.83669591
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.82265054
90	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.80784576
91	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.79931785
92	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.79409757
93	ELF5_23300383_ChIP-Seq_T47D_Human	0.79174230
94	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.78728694
95	EZH2_22144423_ChIP-Seq_EOC_Human	0.78530201
96	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.78513294
97	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.77401567
98	ETV1_20927104_ChIP-Seq_GIST48_Human	0.77116250
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.76833984
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.76833984

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.73256774
2	MP0002132_abnormal_respiratory_system	4.47683460
3	MP0003315_abnormal_perineum_morphology	4.17918908
4	MP0005394_taste/olfaction_phenotype	3.74618772
5	MP0005499_abnormal_olfactory_system	3.74618772
6	MP0005410_abnormal_fertilization	3.68362818
7	MP0001984_abnormal_olfaction	3.47925942
8	MP0001529_abnormal_vocalization	3.25383859
9	MP0008789_abnormal_olfactory_epithelium	3.17277790
10	MP0002102_abnormal_ear_morphology	2.96070075
11	MP0008004_abnormal_stomach_pH	2.85069843
12	MP0002638_abnormal_pupillary_reflex	2.39488988
13	MP0006072_abnormal_retinal_apoptosis	2.37174005
14	MP0005187_abnormal_penis_morphology	2.36102074
15	MP0001188_hyperpigmentation	2.29347677
16	MP0002160_abnormal_reproductive_system	2.21102587
17	MP0005248_abnormal_Harderian_gland	2.20878117
18	MP0010094_abnormal_chromosome_stability	2.19082939
19	MP0002822_catalepsy	2.14131833
20	MP0002233_abnormal_nose_morphology	2.08296325
21	MP0009697_abnormal_copulation	1.95216244
22	MP0005253_abnormal_eye_physiology	1.76632110
23	MP0003698_abnormal_male_reproductive	1.60586813
24	MP0008058_abnormal_DNA_repair	1.50991873
25	MP0001929_abnormal_gametogenesis	1.45500643
26	MP0001270_distended_abdomen	1.45350803
27	MP0004381_abnormal_hair_follicle	1.43212947
28	MP0002249_abnormal_larynx_morphology	1.41139700
29	MP0005423_abnormal_somatic_nervous	1.40028115
30	MP0003693_abnormal_embryo_hatching	1.39096194
31	MP0000049_abnormal_middle_ear	1.38264008
32	MP0005391_vision/eye_phenotype	1.36342582
33	MP0005389_reproductive_system_phenotype	1.25080092
34	MP0003195_calcinosis	1.19503413
35	MP0002127_abnormal_cardiovascular_syste	1.18915982
36	MP0003385_abnormal_body_wall	1.15075256
37	MP0008995_early_reproductive_senescence	1.11602513
38	MP0006036_abnormal_mitochondrial_physio	1.10145094
39	MP0003890_abnormal_embryonic-extraembry	1.09028208
40	MP0003868_abnormal_feces_composition	1.08621953
41	MP0004272_abnormal_basement_membrane	1.08102893
42	MP0000465_gastrointestinal_hemorrhage	1.07207999
43	MP0003077_abnormal_cell_cycle	1.06697079
44	MP0004859_abnormal_synaptic_plasticity	1.06597954
45	MP0010386_abnormal_urinary_bladder	1.03455246
46	MP0001502_abnormal_circadian_rhythm	1.01635128
47	MP0008007_abnormal_cellular_replicative	1.01517596
48	MP0001919_abnormal_reproductive_system	1.00951831
49	MP0006276_abnormal_autonomic_nervous	0.97089187
50	MP0002092_abnormal_eye_morphology	0.96933117
51	MP0005647_abnormal_sex_gland	0.95177059
52	MP0002653_abnormal_ependyma_morphology	0.94534298
53	MP0001664_abnormal_digestion	0.91444586
54	MP0003806_abnormal_nucleotide_metabolis	0.91053363
55	MP0002161_abnormal_fertility/fecundity	0.89434767
56	MP0001849_ear_inflammation	0.86854496
57	MP0001986_abnormal_taste_sensitivity	0.86178864
58	MP0002210_abnormal_sex_determination	0.85946742
59	MP0003656_abnormal_erythrocyte_physiolo	0.85007937
60	MP0003938_abnormal_ear_development	0.84004424
61	MP0001145_abnormal_male_reproductive	0.83537602
62	MP0002295_abnormal_pulmonary_circulatio	0.82913461
63	MP0003937_abnormal_limbs/digits/tail_de	0.82159254
64	MP0002837_dystrophic_cardiac_calcinosis	0.81721237
65	MP0000372_irregular_coat_pigmentation	0.81419681
66	MP0000653_abnormal_sex_gland	0.81216163
67	MP0004084_abnormal_cardiac_muscle	0.79778171
68	MP0008057_abnormal_DNA_replication	0.79234139
69	MP0004197_abnormal_fetal_growth/weight/	0.78562424
70	MP0001905_abnormal_dopamine_level	0.78054855
71	MP0004811_abnormal_neuron_physiology	0.77370673
72	MP0000749_muscle_degeneration	0.76816401
73	MP0002277_abnormal_respiratory_mucosa	0.75777949
74	MP0003111_abnormal_nucleus_morphology	0.75770479
75	MP0004133_heterotaxia	0.73224409
76	MP0002752_abnormal_somatic_nervous	0.72820833
77	MP0003635_abnormal_synaptic_transmissio	0.71862577
78	MP0002282_abnormal_trachea_morphology	0.70390165
79	MP0001879_abnormal_lymphatic_vessel	0.69471165
80	MP0003755_abnormal_palate_morphology	0.69164732
81	MP0002138_abnormal_hepatobiliary_system	0.69086446
82	MP0006035_abnormal_mitochondrial_morpho	0.67946646
83	MP0003763_abnormal_thymus_physiology	0.67174186
84	MP0003935_abnormal_craniofacial_develop	0.66003066
85	MP0001968_abnormal_touch/_nociception	0.65774539
86	MP0004510_myositis	0.65568988
87	MP0000762_abnormal_tongue_morphology	0.65258232
88	MP0005646_abnormal_pituitary_gland	0.63975953
89	MP0000537_abnormal_urethra_morphology	0.63093717
90	MP0005620_abnormal_muscle_contractility	0.61814342
91	MP0003936_abnormal_reproductive_system	0.61523466
92	MP0008877_abnormal_DNA_methylation	0.61235053
93	MP0001486_abnormal_startle_reflex	0.61118821
94	MP0004043_abnormal_pH_regulation	0.59620535
95	MP0001764_abnormal_homeostasis	0.59599442
96	MP0008932_abnormal_embryonic_tissue	0.59003523
97	MP0010368_abnormal_lymphatic_system	0.58725025
98	MP0000678_abnormal_parathyroid_gland	0.58245774
99	MP0002108_abnormal_muscle_morphology	0.58225191
100	MP0000751_myopathy	0.57324398

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.92241445
2	Abnormal ciliary motility (HP:0012262)	6.37005072
3	Abnormal respiratory motile cilium physiology (HP:0012261)	6.17486126
4	Abnormal respiratory motile cilium morphology (HP:0005938)	6.00130133
5	Abnormal respiratory epithelium morphology (HP:0012253)	6.00130133
6	Absent/shortened dynein arms (HP:0200106)	5.98922144
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.98922144
8	Rhinitis (HP:0012384)	5.29245947
9	Abnormal sex determination (HP:0012244)	4.45443515
10	Sex reversal (HP:0012245)	4.45443515
11	Gonadal dysgenesis (HP:0000133)	4.17192755
12	True hermaphroditism (HP:0010459)	4.16335890
13	Abnormality of the columella (HP:0009929)	4.09686825
14	Bronchiectasis (HP:0002110)	3.66645610
15	Chronic bronchitis (HP:0004469)	3.62058646
16	Male pseudohermaphroditism (HP:0000037)	3.59073984
17	Reduced antithrombin III activity (HP:0001976)	3.26805658
18	Resting tremor (HP:0002322)	3.16860977
19	Urinary urgency (HP:0000012)	3.10879294
20	Nasal polyposis (HP:0100582)	3.09610418
21	Pancreatic fibrosis (HP:0100732)	3.05707548
22	Pancreatic cysts (HP:0001737)	3.00515169
23	Infertility (HP:0000789)	2.94602868
24	Occipital encephalocele (HP:0002085)	2.83893549
25	Median cleft lip (HP:0000161)	2.73201544
26	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.67116530
27	Hypoplasia of the uterus (HP:0000013)	2.65721796
28	Retinal dysplasia (HP:0007973)	2.62562352
29	Atonic seizures (HP:0010819)	2.59511703
30	Chronic sinusitis (HP:0011109)	2.57154790
31	Recurrent sinusitis (HP:0011108)	2.50254504
32	Thoracic kyphosis (HP:0002942)	2.49819826
33	High anterior hairline (HP:0009890)	2.37659696
34	Abnormality of the nasal mucosa (HP:0000433)	2.36933168
35	Facial hemangioma (HP:0000329)	2.36348492
36	Nephrogenic diabetes insipidus (HP:0009806)	2.32389487
37	Bifid scrotum (HP:0000048)	2.32029011
38	Aplasia/hypoplasia of the uterus (HP:0008684)	2.31158158
39	Gonadotropin excess (HP:0000837)	2.26803498
40	Abnormality of the frontal sinuses (HP:0002687)	2.25922311
41	Capillary hemangiomas (HP:0005306)	2.25475509
42	Inability to walk (HP:0002540)	2.24391421
43	Cystic liver disease (HP:0006706)	2.23739740
44	Protruding tongue (HP:0010808)	2.22201231
45	Bile duct proliferation (HP:0001408)	2.21969066
46	Abnormal biliary tract physiology (HP:0012439)	2.21969066
47	Carpal bone hypoplasia (HP:0001498)	2.16937696
48	Sensory axonal neuropathy (HP:0003390)	2.15668848
49	Gait imbalance (HP:0002141)	2.14541029
50	Postural instability (HP:0002172)	2.14133657
51	Chronic hepatic failure (HP:0100626)	2.13829798
52	Congenital primary aphakia (HP:0007707)	2.12283590
53	Colitis (HP:0002583)	2.08275508
54	Proximal amyotrophy (HP:0007126)	2.07092495
55	Abnormality of the shoulder girdle musculature (HP:0001435)	2.06167453
56	Tubulointerstitial nephritis (HP:0001970)	2.05551463
57	Vitreoretinal degeneration (HP:0000655)	2.03793268
58	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.03513779
59	Poor coordination (HP:0002370)	2.00928987
60	Hypothermia (HP:0002045)	1.97378231
61	Anencephaly (HP:0002323)	1.95628669
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.95130319
63	Sloping forehead (HP:0000340)	1.94546634
64	Bronchitis (HP:0012387)	1.90923331
65	Abnormal hair whorl (HP:0010721)	1.90642348
66	Abnormality of the ileum (HP:0001549)	1.90309037
67	Postaxial foot polydactyly (HP:0001830)	1.88940490
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87905855
69	Intestinal atresia (HP:0011100)	1.82853129
70	Ventricular fibrillation (HP:0001663)	1.82051539
71	Recurrent otitis media (HP:0000403)	1.81160701
72	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.78993212
73	Neoplasm of the oral cavity (HP:0100649)	1.75651044
74	Meckel diverticulum (HP:0002245)	1.74517519
75	Cortical dysplasia (HP:0002539)	1.70778815
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69901987
77	Molar tooth sign on MRI (HP:0002419)	1.69750094
78	Abnormality of midbrain morphology (HP:0002418)	1.69750094
79	Medial flaring of the eyebrow (HP:0010747)	1.68899123
80	Cerebellar dysplasia (HP:0007033)	1.66610537
81	Benign neoplasm of the central nervous system (HP:0100835)	1.66467851
82	Thickened helices (HP:0000391)	1.65651920
83	Postaxial hand polydactyly (HP:0001162)	1.65363694
84	Preaxial hand polydactyly (HP:0001177)	1.63844645
85	Absent speech (HP:0001344)	1.63487721
86	Male infertility (HP:0003251)	1.63144968
87	Self-mutilation (HP:0000742)	1.62345993
88	Volvulus (HP:0002580)	1.60051580
89	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.58733885
90	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.58733885
91	Germ cell neoplasia (HP:0100728)	1.56827600
92	Hyperventilation (HP:0002883)	1.55235994
93	Vaginal atresia (HP:0000148)	1.53841049
94	Scapular winging (HP:0003691)	1.53701013
95	Eosinophilia (HP:0001880)	1.52990046
96	Genital tract atresia (HP:0001827)	1.52374101
97	Hyperglycinemia (HP:0002154)	1.52368375
98	Broad foot (HP:0001769)	1.52097984
99	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.51857702
100	Hepatoblastoma (HP:0002884)	1.51395677

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	7.72094306
2	MARK3	4.32336284
3	NEK2	4.20539678
4	NEK1	3.87369192
5	CCNB1	2.77735906
6	MAP2K7	2.52503557
7	EPHB1	2.51068034
8	ZAK	2.47543374
9	CSNK1A1L	2.42247109
10	CDK3	2.32489258
11	LATS1	2.29139691
12	CSNK1G3	2.15032878
13	MYLK	2.06135650
14	CSNK1G1	1.91395692
15	CSNK1G2	1.89780350
16	STK38L	1.78257903
17	EIF2AK3	1.68025199
18	BMPR1B	1.64735736
19	PBK	1.52641602
20	MAPK15	1.48185958
21	OBSCN	1.43232378
22	RPS6KA5	1.32714348
23	MAPK13	1.30344337
24	DYRK3	1.27241119
25	TLK1	1.26365147
26	RPS6KA4	1.22642802
27	EEF2K	1.12549112
28	SGK223	1.10517823
29	SGK494	1.10517823
30	SRPK1	0.99747938
31	FGFR2	0.97879794
32	RAF1	0.94146744
33	CDK14	0.93580692
34	STK38	0.91764280
35	ARAF	0.91752007
36	TAOK1	0.88745437
37	CASK	0.86403882
38	MAPK12	0.82956785
39	PRKCQ	0.82827222
40	MELK	0.82247123
41	MAP3K10	0.80899542
42	BCR	0.79697503
43	PKN2	0.78524659
44	KSR2	0.75018760
45	ERBB3	0.74602348
46	VRK1	0.72652791
47	DYRK2	0.71375495
48	PLK2	0.70205233
49	MAP3K5	0.69157374
50	MAP3K13	0.67116443
51	PAK1	0.64336270
52	EIF2AK1	0.59563803
53	NUAK1	0.57326306
54	ATM	0.55589672
55	PLK1	0.54657786
56	VRK2	0.54646746
57	BTK	0.53473907
58	PLK4	0.53201618
59	EPHA3	0.53133692
60	MAPKAPK5	0.52415483
61	CDK9	0.50974405
62	RPS6KB1	0.49795274
63	IRAK2	0.49535772
64	WNK3	0.47568433
65	KSR1	0.47273117
66	NTRK2	0.46778154
67	SGK2	0.46683275
68	CSNK1A1	0.46251274
69	NLK	0.46016847
70	FRK	0.45488025
71	AURKB	0.45228634
72	TGFBR1	0.43422847
73	MAP3K7	0.42577633
74	PKN1	0.41945306
75	DYRK1A	0.41693832
76	DAPK3	0.41649182
77	STK4	0.41202846
78	BUB1	0.39777933
79	CDC42BPA	0.38810495
80	MAPKAPK3	0.38756698
81	INSRR	0.37864415
82	GRK6	0.36400604
83	ATR	0.31970154
84	MAP3K4	0.31180502
85	MAP3K9	0.31140333
86	LATS2	0.29120045
87	PRKAA1	0.28837488
88	NME1	0.28763194
89	CSNK1D	0.28705210
90	MAP3K1	0.28498428
91	TTK	0.28486305
92	BRAF	0.27597753
93	EPHA4	0.26992150
94	AURKA	0.25725685
95	EGFR	0.23859751
96	MOS	0.23357104
97	CDK5	0.23251893
98	MINK1	0.23202890
99	CDK12	0.21776212
100	PAK3	0.21249784

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	4.16520358
2	Olfactory transduction_Homo sapiens_hsa04740	3.13406561
3	Gap junction_Homo sapiens_hsa04540	2.76548916
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.62897407
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.62884157
6	Circadian rhythm_Homo sapiens_hsa04710	2.41275438
7	Butanoate metabolism_Homo sapiens_hsa00650	2.39030645
8	Propanoate metabolism_Homo sapiens_hsa00640	2.15812015
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.14396663
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.10424376
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.04820923
12	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.00279087
13	Alcoholism_Homo sapiens_hsa05034	1.78444758
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.77624968
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.75249509
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.68891669
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.58183861
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.54596500
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.53418980
20	Glutathione metabolism_Homo sapiens_hsa00480	1.50591075
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.47576312
22	Phenylalanine metabolism_Homo sapiens_hsa00360	1.42002463
23	mRNA surveillance pathway_Homo sapiens_hsa03015	1.39830371
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.39236029
25	Regulation of autophagy_Homo sapiens_hsa04140	1.38553635
26	Oocyte meiosis_Homo sapiens_hsa04114	1.37998100
27	Basal transcription factors_Homo sapiens_hsa03022	1.35830629
28	Apoptosis_Homo sapiens_hsa04210	1.34978699
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.34486557
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.29220100
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.29023882
32	DNA replication_Homo sapiens_hsa03030	1.26060519
33	Arginine biosynthesis_Homo sapiens_hsa00220	1.24193672
34	RNA degradation_Homo sapiens_hsa03018	1.21106816
35	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.18507747
36	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.17399534
37	Endometrial cancer_Homo sapiens_hsa05213	1.17221972
38	Phagosome_Homo sapiens_hsa04145	1.15579471
39	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.14615969
40	Taste transduction_Homo sapiens_hsa04742	1.12328437
41	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.10226356
42	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.08150052
43	Thyroid cancer_Homo sapiens_hsa05216	1.00963918
44	Base excision repair_Homo sapiens_hsa03410	0.98899780
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.98627074
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.98521362
47	Phototransduction_Homo sapiens_hsa04744	0.98018725
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.97138550
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96122867
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.92899012
51	Purine metabolism_Homo sapiens_hsa00230	0.91225837
52	Gastric acid secretion_Homo sapiens_hsa04971	0.90972253
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.89300920
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88933804
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87254209
56	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.87186645
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83993038
58	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80569670
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.79673977
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75118071
61	Peroxisome_Homo sapiens_hsa04146	0.73344729
62	RNA transport_Homo sapiens_hsa03013	0.71651199
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69860756
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.67916155
65	Spliceosome_Homo sapiens_hsa03040	0.66900915
66	Cell cycle_Homo sapiens_hsa04110	0.66676362
67	Renin secretion_Homo sapiens_hsa04924	0.66039708
68	Prostate cancer_Homo sapiens_hsa05215	0.65579702
69	Salivary secretion_Homo sapiens_hsa04970	0.64052438
70	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.63277359
71	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.60784607
72	Melanogenesis_Homo sapiens_hsa04916	0.58923658
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.57456635
74	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.57166543
75	p53 signaling pathway_Homo sapiens_hsa04115	0.54134454
76	Melanoma_Homo sapiens_hsa05218	0.51024025
77	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49316823
78	Circadian entrainment_Homo sapiens_hsa04713	0.49140619
79	Choline metabolism in cancer_Homo sapiens_hsa05231	0.48882633
80	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.47409833
81	Fatty acid degradation_Homo sapiens_hsa00071	0.45528882
82	PPAR signaling pathway_Homo sapiens_hsa03320	0.42767288
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.40838170
84	AMPK signaling pathway_Homo sapiens_hsa04152	0.40428069
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.39557170
86	Glucagon signaling pathway_Homo sapiens_hsa04922	0.38217010
87	GABAergic synapse_Homo sapiens_hsa04727	0.38163890
88	Non-small cell lung cancer_Homo sapiens_hsa05223	0.37989906
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.37540753
90	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.37336407
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.37147791
92	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.36801295
93	Carbon metabolism_Homo sapiens_hsa01200	0.35797023
94	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.35643429
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.35203948
96	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.34929749
97	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.34278823
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.33889567
99	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.33513860
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33143690

TEX21P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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