TEX22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.78174702
2epithelial cilium movement (GO:0003351)9.65128927
3plasma membrane fusion (GO:0045026)9.57412169
4motile cilium assembly (GO:0044458)9.39103607
5reproduction (GO:0000003)8.86107276
6piRNA metabolic process (GO:0034587)8.68099683
7regulation of cilium movement (GO:0003352)8.31247264
8male meiosis (GO:0007140)8.10909397
9cilium movement (GO:0003341)8.04672246
10synaptonemal complex organization (GO:0070193)7.94567895
11synaptonemal complex assembly (GO:0007130)7.76476341
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.66944576
13negative regulation of inclusion body assembly (GO:0090084)7.26831865
14sperm capacitation (GO:0048240)7.22840082
15single fertilization (GO:0007338)7.10418661
16spermatogenesis (GO:0007283)6.71804097
17male gamete generation (GO:0048232)6.69386378
18organic cation transport (GO:0015695)6.36995752
19fertilization (GO:0009566)6.21718392
20gamete generation (GO:0007276)6.15038338
21microtubule depolymerization (GO:0007019)5.97389303
22regulation of inclusion body assembly (GO:0090083)5.89646812
23DNA methylation involved in gamete generation (GO:0043046)5.53027396
24germ cell development (GO:0007281)5.52724010
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.48955321
26male meiosis I (GO:0007141)5.46116830
27chromosome organization involved in meiosis (GO:0070192)5.36888412
28calcium ion-dependent exocytosis (GO:0017156)5.31806003
29ventricular system development (GO:0021591)5.25275537
30chromosome condensation (GO:0030261)5.05054680
31seminiferous tubule development (GO:0072520)5.02405680
32microtubule severing (GO:0051013)4.94469663
33cell recognition (GO:0008037)4.92867068
34DNA packaging (GO:0006323)4.88039648
35regulation of microtubule-based movement (GO:0060632)4.84619751
36phosphatidylglycerol biosynthetic process (GO:0006655)4.83990799
37multicellular organismal reproductive process (GO:0048609)4.82114985
38spermatid nucleus differentiation (GO:0007289)4.81177542
39meiotic nuclear division (GO:0007126)4.78953163
40regulation of megakaryocyte differentiation (GO:0045652)4.58224617
41glycerol ether metabolic process (GO:0006662)4.39395343
42meiosis I (GO:0007127)4.39013209
43positive regulation of megakaryocyte differentiation (GO:0045654)4.38675707
44left/right pattern formation (GO:0060972)4.32960266
45regulation of T-helper 2 cell differentiation (GO:0045628)4.28121170
46regulation of germinal center formation (GO:0002634)4.27281109
47positive regulation of B cell differentiation (GO:0045579)4.23051515
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.19092684
49pyrimidine nucleotide catabolic process (GO:0006244)4.07105263
50meiotic cell cycle (GO:0051321)4.06615400
51cardiolipin metabolic process (GO:0032048)4.06573537
52ether metabolic process (GO:0018904)4.05414925
53DNA strand renaturation (GO:0000733)4.01647013
54chaperone-mediated protein complex assembly (GO:0051131)3.97826986
55poly(A)+ mRNA export from nucleus (GO:0016973)3.94447384
56multicellular organismal development (GO:0007275)3.90093120
57B cell receptor signaling pathway (GO:0050853)3.89649578
58protein localization to cilium (GO:0061512)3.89527789
59single strand break repair (GO:0000012)3.86831269
60protein polyglutamylation (GO:0018095)3.84967687
61UV protection (GO:0009650)3.84599141
62response to peptidoglycan (GO:0032494)3.81545683
63negative regulation of interleukin-8 production (GO:0032717)3.80458514
64purinergic nucleotide receptor signaling pathway (GO:0035590)3.77860369
65misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.76479113
66negative regulation of T-helper cell differentiation (GO:0045623)3.76081761
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.76081761
68GDP-mannose metabolic process (GO:0019673)3.75564634
69genitalia morphogenesis (GO:0035112)3.72733411
70positive thymic T cell selection (GO:0045059)3.65364602
71sequestering of actin monomers (GO:0042989)3.65073440
72sexual reproduction (GO:0019953)3.63285894
73response to misfolded protein (GO:0051788)3.62944041
74positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.60189395
75regulation of skeletal muscle contraction (GO:0014819)3.59314275
76embryonic process involved in female pregnancy (GO:0060136)3.58067051
77response to protozoan (GO:0001562)3.55560487
78regulation of spindle checkpoint (GO:0090231)3.48791913
79monoubiquitinated protein deubiquitination (GO:0035520)3.48114135
80negative regulation of cell aging (GO:0090344)3.46124112
81mannose metabolic process (GO:0006013)3.41716417
82protein K11-linked deubiquitination (GO:0035871)3.32729886
83carnitine transport (GO:0015879)3.31930994
84amino-acid betaine transport (GO:0015838)3.31930994
85granulocyte differentiation (GO:0030851)3.31531906
86positive regulation of T-helper cell differentiation (GO:0045624)3.30786681
87defense response to protozoan (GO:0042832)3.29353623
88negative regulation of B cell apoptotic process (GO:0002903)3.28386227
89deoxyribonucleotide catabolic process (GO:0009264)3.28171698
90negative thymic T cell selection (GO:0045060)3.27916492
91negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26729960
92response to pheromone (GO:0019236)3.26468967
93positive regulation of isotype switching (GO:0045830)3.24714575
94cellular extravasation (GO:0045123)3.24509598
95cellular response to ATP (GO:0071318)3.24107802
96carnitine transmembrane transport (GO:1902603)3.22848324
97protein refolding (GO:0042026)3.19799674
98synapsis (GO:0007129)3.15917498
99regulation of cytokine production involved in inflammatory response (GO:1900015)3.15245908
100intraciliary transport (GO:0042073)3.14817755
101meiotic cell cycle process (GO:1903046)3.13591685
102positive regulation of DNA recombination (GO:0045911)3.13349912
103positive regulation of gamma-delta T cell activation (GO:0046645)3.12307974
104positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.10540631
105purine deoxyribonucleotide catabolic process (GO:0009155)3.07371837
106gene silencing by RNA (GO:0031047)3.06851463
107meiotic chromosome segregation (GO:0045132)3.06554313
108mast cell degranulation (GO:0043303)3.06412357
109mast cell activation involved in immune response (GO:0002279)3.06412357
110Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06129797
111regulation of T-helper 1 cell differentiation (GO:0045625)3.05970737
112mitotic cell cycle arrest (GO:0071850)3.05919171
113adenosine receptor signaling pathway (GO:0001973)3.05673678
114regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03194828
115negative regulation of granulocyte differentiation (GO:0030853)3.02585777
116nucleus organization (GO:0006997)3.02094208
117mitotic sister chromatid cohesion (GO:0007064)3.01114443
118microtubule polymerization or depolymerization (GO:0031109)3.00773415
119positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.99173594
120positive regulation of macrophage activation (GO:0043032)2.97319756
121negative regulation of type 2 immune response (GO:0002829)2.97159195
122axoneme assembly (GO:0035082)2.96682664
123negative regulation of erythrocyte differentiation (GO:0045647)2.95258789
124peptidyl-arginine N-methylation (GO:0035246)2.95095990
125peptidyl-arginine methylation (GO:0018216)2.95095990
126polyol catabolic process (GO:0046174)2.94751534
127thymic T cell selection (GO:0045061)2.94475471
128interferon-gamma secretion (GO:0072643)2.93854389
129glycolytic process (GO:0006096)2.93387538
130nucleoside diphosphate phosphorylation (GO:0006165)2.91411494
131regulation of interferon-beta biosynthetic process (GO:0045357)2.90978925
132positive regulation of protein homodimerization activity (GO:0090073)2.90610438
133protein insertion into membrane (GO:0051205)2.90465338
134purinergic receptor signaling pathway (GO:0035587)2.90131190
135deoxyribose phosphate catabolic process (GO:0046386)2.89797386
136microtubule-based movement (GO:0007018)2.89317069
137negative regulation of organelle assembly (GO:1902116)2.88454168
138metallo-sulfur cluster assembly (GO:0031163)2.88120435
139iron-sulfur cluster assembly (GO:0016226)2.88120435
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87793917
141cilium organization (GO:0044782)2.87051386
142negative T cell selection (GO:0043383)2.85406599
143alditol metabolic process (GO:0019400)2.84194425
144positive regulation of B cell activation (GO:0050871)2.83137956
145respiratory burst (GO:0045730)2.82814352
146regulation of translation in response to stress (GO:0043555)2.81449835
147negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.80214116
148immunoglobulin mediated immune response (GO:0016064)2.78988242
149negative regulation of tumor necrosis factor production (GO:0032720)2.78037919
150cilium morphogenesis (GO:0060271)2.77440872
151regulation of B cell differentiation (GO:0045577)2.73827800
152G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.72762866
153cellular component assembly involved in morphogenesis (GO:0010927)2.72533428
154cilium assembly (GO:0042384)2.71923532
155regulation of monocyte differentiation (GO:0045655)2.71134514
156negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.67622527
157definitive hemopoiesis (GO:0060216)2.67347039
158RNA localization (GO:0006403)2.66577471
159lactate metabolic process (GO:0006089)2.66016758
160hematopoietic stem cell differentiation (GO:0060218)2.65877025
161DNA duplex unwinding (GO:0032508)2.63631774
162regulation of B cell apoptotic process (GO:0002902)2.63101665
163peptidyl-glutamic acid modification (GO:0018200)2.62519322
164RNA destabilization (GO:0050779)2.61104405
165protein import into peroxisome matrix (GO:0016558)2.60164532
166protein carboxylation (GO:0018214)2.59614535
167peptidyl-glutamic acid carboxylation (GO:0017187)2.59614535
168protein retention in ER lumen (GO:0006621)2.59491891
169gene silencing (GO:0016458)2.59458757
170T cell selection (GO:0045058)2.58187724
171proline biosynthetic process (GO:0006561)2.57487538
172cellular response to exogenous dsRNA (GO:0071360)2.57471559
173regulation of cilium assembly (GO:1902017)2.56984483
174megakaryocyte development (GO:0035855)2.56791377
175regulation of hypersensitivity (GO:0002883)2.56423922
176GTP biosynthetic process (GO:0006183)2.55107693
177modulation by virus of host process (GO:0019054)2.55046287
178positive regulation of interferon-alpha production (GO:0032727)2.54759773
179positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.54541040
180chaperone mediated protein folding requiring cofactor (GO:0051085)2.53443629
181regulation of granulocyte differentiation (GO:0030852)2.53375638
182B cell homeostasis (GO:0001782)2.53003918
183mucosal-associated lymphoid tissue development (GO:0048537)2.52259647
184Peyers patch development (GO:0048541)2.52259647
185peptidyl-histidine modification (GO:0018202)2.51919972
186polyamine biosynthetic process (GO:0006596)2.43080719
187glycerol metabolic process (GO:0006071)2.41502238
188regulation of centriole replication (GO:0046599)2.40828911
189sperm motility (GO:0030317)13.4967407
190fusion of sperm to egg plasma membrane (GO:0007342)12.6206086
191cell wall macromolecule metabolic process (GO:0044036)12.0082012
192cell wall macromolecule catabolic process (GO:0016998)12.0082012
193acrosome reaction (GO:0007340)11.9367947
194acrosome assembly (GO:0001675)11.8587785
195sperm-egg recognition (GO:0035036)11.5198201
196cilium or flagellum-dependent cell motility (GO:0001539)10.7887829
197binding of sperm to zona pellucida (GO:0007339)10.6727371
198multicellular organism reproduction (GO:0032504)10.3548481
199cell-cell recognition (GO:0009988)10.3031793
200axonemal dynein complex assembly (GO:0070286)10.1263108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67222305
2VDR_21846776_ChIP-Seq_THP-1_Human4.43808773
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.22287264
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.12516720
5MYC_22102868_ChIP-Seq_BL_Human3.06334435
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.68875799
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.67457113
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62522029
9VDR_24763502_ChIP-Seq_THP-1_Human2.39031320
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.29755152
11LXR_22292898_ChIP-Seq_THP-1_Human2.28027693
12XRN2_22483619_ChIP-Seq_HELA_Human2.27916837
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.25451151
14MAF_26560356_Chip-Seq_TH2_Human2.24005610
15P68_20966046_ChIP-Seq_HELA_Human2.21416213
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15211060
17VDR_22108803_ChIP-Seq_LS180_Human2.13455083
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09534986
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06956299
20MAF_26560356_Chip-Seq_TH1_Human2.05612709
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05518662
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04954697
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.04287285
24ZNF274_21170338_ChIP-Seq_K562_Hela2.03977028
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.4308614
26CIITA_25753668_ChIP-Seq_RAJI_Human1.97420126
27BCL6_27268052_Chip-Seq_Bcells_Human1.96355589
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.96023834
29UTX_26944678_Chip-Seq_JUKART_Human1.92579826
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92003438
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.86874827
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83929759
33E2F7_22180533_ChIP-Seq_HELA_Human1.81104402
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79437598
35KDM2B_26808549_Chip-Seq_DND41_Human1.74725235
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.74134162
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73924801
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73014108
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72313907
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.72116099
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70442753
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69955167
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69696787
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68867886
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68574786
46STAT1_17558387_ChIP-Seq_HELA_Human1.67554745
47E2F1_20622854_ChIP-Seq_HELA_Human1.67077666
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64292932
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62845879
50TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.61815140
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59776124
52TCF7_22412390_ChIP-Seq_EML_Mouse1.59193503
53SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58924982
54* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58049910
55GATA3_21867929_ChIP-Seq_CD8_Mouse1.56986269
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53093219
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52072865
58SMC4_20622854_ChIP-Seq_HELA_Human1.50583355
59GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48007797
60GABP_19822575_ChIP-Seq_HepG2_Human1.47976047
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44839805
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.44492787
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44300401
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43285593
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.43210664
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42680654
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42159333
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41744377
69FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41481597
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.41332440
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.40912692
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.40728037
73CTCF_21964334_Chip-Seq_Bcells_Human1.40327782
74RACK7_27058665_Chip-Seq_MCF-7_Human1.39910109
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.38951095
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37813087
77RARB_24833708_ChIP-Seq_LIVER_Mouse1.37719447
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36136841
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.35728397
80SPI1_23547873_ChIP-Seq_NB4_Human1.35236958
81KDM2B_26808549_Chip-Seq_REH_Human1.35093536
82* CTCF_26484167_Chip-Seq_Bcells_Mouse1.34203178
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.33439934
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32650353
85CBP_20019798_ChIP-Seq_JUKART_Human1.32650026
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32650026
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.32370266
88CTCF_21964334_ChIP-Seq_BJAB-B_Human1.31759455
89SCL_19346495_ChIP-Seq_HPC-7_Human1.31264785
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31056365
91P53_21459846_ChIP-Seq_SAOS-2_Human1.30435366
92KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30136641
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29082636
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29016368
95LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28939227
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.28351191
97KDM5A_27292631_Chip-Seq_BREAST_Human1.28348321
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28134178
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27709065
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27143810
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.26895269
102IRF8_21731497_ChIP-ChIP_J774_Mouse1.26585215
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25127318
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24645962
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24459908
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24402481
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23828544
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23587623
109ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23467405
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23356521
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22322745
112RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21827097
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21643180
114RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21362753
115GATA3_21867929_ChIP-Seq_TH1_Mouse1.21214020
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20264687
117REST_21632747_ChIP-Seq_MESCs_Mouse1.19208731
118P300_27268052_Chip-Seq_Bcells_Human1.19155217
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19110995
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17266783
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.16886724
122GF1_26923725_Chip-Seq_HPCs_Mouse1.16773654
123SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16752486
124SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16033796
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15744612
126NCOR1_26117541_ChIP-Seq_K562_Human1.15327049
127CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13840794
128SRF_21415370_ChIP-Seq_HL-1_Mouse1.13651494
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13380135
130CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13226779
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12437787
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11740692
133SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11554156
134* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11423165
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11242922
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10770917
137CTCF_27219007_Chip-Seq_Bcells_Human1.10438901
138RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09658240
139CBX2_27304074_Chip-Seq_ESCs_Mouse1.08940899
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08939147
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08939147
142RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08411875
143FOXP3_21729870_ChIP-Seq_TREG_Human1.08248217
144SA1_27219007_Chip-Seq_Bcells_Human1.07786887
145PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07615120
146SPI1_26923725_Chip-Seq_HPCs_Mouse1.06452281
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06416217
148GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06365373
149TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06141976
150ERG_20517297_ChIP-Seq_VCAP_Human1.05975614
151MYC_27129775_Chip-Seq_CORNEA_Mouse1.05127948
152YY1_22570637_ChIP-Seq_MALME-3M_Human1.04224598
153ESET_19884257_ChIP-Seq_ESCs_Mouse1.03896787
154CRX_20693478_ChIP-Seq_RETINA_Mouse1.03882468
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03395841
156PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03222002
157RARA_24833708_ChIP-Seq_LIVER_Mouse1.02301021
158PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01252680
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00718019
160TET1_21451524_ChIP-Seq_MESCs_Mouse1.00570532
161EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98967462
162GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98863466
163NANOG_18555785_Chip-Seq_ESCs_Mouse0.98536736
164CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97811846
165LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97699323
166OCT4_18555785_Chip-Seq_ESCs_Mouse0.97163599
167ELF1_20517297_ChIP-Seq_JURKAT_Human0.96997795
168CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96389301
169PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92174046
170EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92170576
171P53_22387025_ChIP-Seq_ESCs_Mouse0.91301657
172CTCF_20526341_ChIP-Seq_ESCs_Human0.90584874
173SOX11_22085726_ChIP-Seq_ESNs_Mouse0.90500521
174OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89234883
175FLI1_21867929_ChIP-Seq_CD8_Mouse0.88866536
176NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88660606
177JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87849406
178KLF4_18555785_Chip-Seq_ESCs_Mouse0.86703368
179PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85683785
180EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85644957
181P300_18555785_Chip-Seq_ESCs_Mouse0.85152645
182ESRRB_18555785_Chip-Seq_ESCs_Mouse0.84850868
183SOX2_21211035_ChIP-Seq_LN229_Human0.83983347
184BCOR_27268052_Chip-Seq_Bcells_Human0.83530111
185CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83523965
186PHF8_20622854_ChIP-Seq_HELA_Human0.83253438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07342325
2MP0001929_abnormal_gametogenesis5.64877104
3MP0008877_abnormal_DNA_methylation4.40835699
4MP0002210_abnormal_sex_determination3.58870840
5MP0003172_abnormal_lysosome_physiology3.51263217
6MP0002161_abnormal_fertility/fecundity3.28047682
7MP0003436_decreased_susceptibility_to3.11116664
8MP0001145_abnormal_male_reproductive3.05812107
9MP0005084_abnormal_gallbladder_morpholo3.02137362
10MP0001986_abnormal_taste_sensitivity2.95522426
11MP0002396_abnormal_hematopoietic_system2.84736786
12MP0001873_stomach_inflammation2.82280986
13MP0000653_abnormal_sex_gland2.63378038
14MP0005670_abnormal_white_adipose2.53418222
15MP0001661_extended_life_span2.41054196
16MP0003303_peritoneal_inflammation2.39677243
17MP0005058_abnormal_lysosome_morphology2.39108723
18MP0002653_abnormal_ependyma_morphology2.36094007
19MP0001835_abnormal_antigen_presentation2.18094663
20MP0005171_absent_coat_pigmentation2.14181446
21MP0001188_hyperpigmentation2.03818550
22MP0003763_abnormal_thymus_physiology2.00282866
23MP0005410_abnormal_fertilization16.3562193
24MP0001800_abnormal_humoral_immune1.93545388
25MP0002160_abnormal_reproductive_system1.89016601
26MP0009384_cardiac_valve_regurgitation1.84380935
27MP0001790_abnormal_immune_system1.83841139
28MP0005387_immune_system_phenotype1.83841139
29MP0002822_catalepsy1.83133020
30MP0000685_abnormal_immune_system1.79401711
31MP0004185_abnormal_adipocyte_glucose1.75863726
32MP0002398_abnormal_bone_marrow1.71243819
33MP0002723_abnormal_immune_serum1.67468723
34MP0002452_abnormal_antigen_presenting1.66498857
35MP0002420_abnormal_adaptive_immunity1.66035093
36MP0003646_muscle_fatigue1.63347598
37MP0001819_abnormal_immune_cell1.62615696
38MP0001348_abnormal_lacrimal_gland1.60298390
39MP0005076_abnormal_cell_differentiation1.59363542
40MP0005025_abnormal_response_to1.55637870
41MP0000689_abnormal_spleen_morphology1.52127968
42MP0005000_abnormal_immune_tolerance1.46105289
43MP0005623_abnormal_meninges_morphology1.45036959
44MP0002722_abnormal_immune_system1.42320757
45MP0000716_abnormal_immune_system1.39773707
46MP0005464_abnormal_platelet_physiology1.37832300
47MP0002429_abnormal_blood_cell1.37469087
48MP0005409_darkened_coat_color1.37169429
49MP0002419_abnormal_innate_immunity1.36956490
50MP0004233_abnormal_muscle_weight1.35328631
51MP0000703_abnormal_thymus_morphology1.32279004
52MP0004381_abnormal_hair_follicle1.31960006
53MP0005083_abnormal_biliary_tract1.27611507
54MP0005423_abnormal_somatic_nervous1.26533472
55MP0002148_abnormal_hypersensitivity_rea1.24453440
56MP0008260_abnormal_autophagy1.22935701
57MP0005451_abnormal_body_composition1.12822181
58MP0005330_cardiomyopathy1.12343110
59MP0002019_abnormal_tumor_incidence1.12117393
60MP0000013_abnormal_adipose_tissue1.11066603
61MP0003693_abnormal_embryo_hatching1.10641136
62MP0008058_abnormal_DNA_repair1.09677922
63MP0002282_abnormal_trachea_morphology1.05530392
64MP0000465_gastrointestinal_hemorrhage1.04351172
65MP0001984_abnormal_olfaction1.04193099
66MP0009333_abnormal_splenocyte_physiolog1.04069253
67MP0003191_abnormal_cellular_cholesterol1.03025022
68MP0008057_abnormal_DNA_replication0.96951874
69MP0005389_reproductive_system_phenotype0.96910291
70MP0002009_preneoplasia0.96691984
71MP0003806_abnormal_nucleotide_metabolis0.95682206
72MP0005647_abnormal_sex_gland0.94101125
73MP0001765_abnormal_ion_homeostasis0.92683453
74MP0000470_abnormal_stomach_morphology0.90886538
75MP0004130_abnormal_muscle_cell0.90785217
76MP0008875_abnormal_xenobiotic_pharmacok0.88781949
77MP0000569_abnormal_digit_pigmentation0.87436391
78MP0005075_abnormal_melanosome_morpholog0.86783306
79MP0002138_abnormal_hepatobiliary_system0.86631423
80MP0000003_abnormal_adipose_tissue0.86525103
81MP0003656_abnormal_erythrocyte_physiolo0.86460865
82MP0010094_abnormal_chromosome_stability0.84147817
83MP0000490_abnormal_crypts_of0.83982240
84MP0009046_muscle_twitch0.83811473
85MP0001845_abnormal_inflammatory_respons0.82408861
86MP0008469_abnormal_protein_level0.82262616
87MP0005501_abnormal_skin_physiology0.82123830
88MP0009931_abnormal_skin_appearance0.79882552
89MP0002234_abnormal_pharynx_morphology0.78970081
90MP0009785_altered_susceptibility_to0.77360889
91MP0000681_abnormal_thyroid_gland0.76727231
92MP0003453_abnormal_keratinocyte_physiol0.76189978
93MP0001502_abnormal_circadian_rhythm0.74701398
94MP0001664_abnormal_digestion0.72233321
95MP0005375_adipose_tissue_phenotype0.71147550
96MP0003011_delayed_dark_adaptation0.70512817
97MP0003300_gastrointestinal_ulcer0.69520763
98MP0000750_abnormal_muscle_regeneration0.68396541
99MP0001663_abnormal_digestive_system0.66692514
100MP0005671_abnormal_response_to0.66683613
101MP0008995_early_reproductive_senescence0.65394768
102MP0005397_hematopoietic_system_phenotyp0.64964305
103MP0001545_abnormal_hematopoietic_system0.64964305
104MP0009278_abnormal_bone_marrow0.64730643
105MP0003115_abnormal_respiratory_system0.57306128
106MP0000358_abnormal_cell_content/0.55078758
107MP0003878_abnormal_ear_physiology0.54885357
108MP0005377_hearing/vestibular/ear_phenot0.54885357
109MP0005636_abnormal_mineral_homeostasis0.54881324
110MP0008007_abnormal_cellular_replicative0.54507744
111MP0003950_abnormal_plasma_membrane0.53519362
112MP0001764_abnormal_homeostasis0.50221520
113MP0001324_abnormal_eye_pigmentation0.48996368
114MP0003329_amyloid_beta_deposits0.48855165
115MP0003699_abnormal_female_reproductive0.47489662
116MP0003786_premature_aging0.45657195
117MP0005666_abnormal_adipose_tissue0.45648190
118MP0003111_abnormal_nucleus_morphology0.44626448
119MP0001293_anophthalmia0.44358665
120MP0002928_abnormal_bile_duct0.44272209
121MP0004808_abnormal_hematopoietic_stem0.43468885
122MP0006036_abnormal_mitochondrial_physio0.40611518
123MP0004036_abnormal_muscle_relaxation0.38093599
124MP0010307_abnormal_tumor_latency0.37707360
125MP0005253_abnormal_eye_physiology0.35758813
126MP0002132_abnormal_respiratory_system0.35038339
127MP0002269_muscular_atrophy0.33833964
128MP0001119_abnormal_female_reproductive0.33475021
129MP0009115_abnormal_fat_cell0.33367368
130MP0005391_vision/eye_phenotype0.31314758
131MP0000604_amyloidosis0.29747582
132MP0000534_abnormal_ureter_morphology0.28082341
133MP0001730_embryonic_growth_arrest0.27797017
134MP0005551_abnormal_eye_electrophysiolog0.26247533
135MP0002736_abnormal_nociception_after0.26186366
136MP0002971_abnormal_brown_adipose0.25155561
137MP0004811_abnormal_neuron_physiology0.24715745
138MP0004019_abnormal_vitamin_homeostasis0.24690335
139MP0000313_abnormal_cell_death0.24635262
140MP0004133_heterotaxia0.24562927
141MP0003633_abnormal_nervous_system0.24054950
142MP0002405_respiratory_system_inflammati0.23476239
143MP0003942_abnormal_urinary_system0.22641312
144MP0004134_abnormal_chest_morphology0.21446749
145MP0003631_nervous_system_phenotype0.20558218
146MP0002092_abnormal_eye_morphology0.20172377
147MP0003861_abnormal_nervous_system0.20107733
148MP0005174_abnormal_tail_pigmentation0.20018881
149MP0002169_no_abnormal_phenotype0.19817273
150MP0002873_normal_phenotype0.19618506
151MP0001727_abnormal_embryo_implantation0.18643501
152MP0003948_abnormal_gas_homeostasis0.18592278
153MP0002152_abnormal_brain_morphology0.18132476
154MP0006035_abnormal_mitochondrial_morpho0.17757873
155MP0008961_abnormal_basal_metabolism0.17451834
156MP0000015_abnormal_ear_pigmentation0.17259643
157MP0003077_abnormal_cell_cycle0.15398114
158MP0002295_abnormal_pulmonary_circulatio0.15392468
159MP0004742_abnormal_vestibular_system0.14915249
160MP0003045_fibrosis0.14672974
161MP0003183_abnormal_peptide_metabolism0.14628505
162MP0003936_abnormal_reproductive_system0.13252696
163MP0000001_mammalian_phenotype0.12616960
164MP0000920_abnormal_myelination0.12146694
165MP0004043_abnormal_pH_regulation0.12097769
166MP0002084_abnormal_developmental_patter0.11826960
167MP0002229_neurodegeneration0.11182505
168MP0003943_abnormal_hepatobiliary_system0.10799185
169MP0003879_abnormal_hair_cell0.10322256
170MP0001270_distended_abdomen0.09529137
171MP0000462_abnormal_digestive_system0.09387764
172MP0001849_ear_inflammation0.09258328
173MP0005380_embryogenesis_phenotype0.08957516
174MP0001672_abnormal_embryogenesis/_devel0.08957516

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.38006041
2Abnormal respiratory motile cilium morphology (HP:0005938)9.00282910
3Abnormal respiratory epithelium morphology (HP:0012253)9.00282910
4Rhinitis (HP:0012384)7.80516836
5Chronic bronchitis (HP:0004469)7.56189811
6Abnormal ciliary motility (HP:0012262)7.28321592
7Infertility (HP:0000789)6.89166466
8Nasal polyposis (HP:0100582)6.53180091
9Abnormality of the nasal mucosa (HP:0000433)5.36280086
10Bronchiectasis (HP:0002110)4.63712510
11Agammaglobulinemia (HP:0004432)4.63676451
12Bronchitis (HP:0012387)4.63039688
13Nephronophthisis (HP:0000090)4.45726858
14Attenuation of retinal blood vessels (HP:0007843)4.39162169
15Male infertility (HP:0003251)4.27842192
16Increased intramyocellular lipid droplets (HP:0012240)3.88522629
17Ragged-red muscle fibers (HP:0003200)3.78201806
18Poikiloderma (HP:0001029)3.72452656
19Eczematoid dermatitis (HP:0000976)3.63058437
20Cellulitis (HP:0100658)3.58169108
21Increased muscle lipid content (HP:0009058)3.56030518
22Abnormal spermatogenesis (HP:0008669)3.52397179
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.50018173
24Abnormality of the renal medulla (HP:0100957)3.35885099
25Thrombocytosis (HP:0001894)3.32286074
26Recurrent otitis media (HP:0000403)3.32086882
27Recurrent bacterial skin infections (HP:0005406)3.25950675
28Recurrent sinusitis (HP:0011108)3.24550220
29Recurrent cutaneous fungal infections (HP:0011370)3.18805447
30Chronic mucocutaneous candidiasis (HP:0002728)3.18805447
31Colitis (HP:0002583)3.17565748
32Annular pancreas (HP:0001734)3.14681827
33Facial hemangioma (HP:0000329)3.08252809
34Intestinal fistula (HP:0100819)3.06606815
35Vaginal fistula (HP:0004320)3.02261092
36Recurrent abscess formation (HP:0002722)3.01478744
37Rectovaginal fistula (HP:0000143)2.99551847
38Rectal fistula (HP:0100590)2.99551847
39Recurrent fungal infections (HP:0002841)2.99084592
40Testicular atrophy (HP:0000029)2.98042410
41Microvesicular hepatic steatosis (HP:0001414)2.90084712
42Tubulointerstitial nephritis (HP:0001970)2.88160095
43Panhypogammaglobulinemia (HP:0003139)2.83164465
44Rib fusion (HP:0000902)2.82990893
45Renal Fanconi syndrome (HP:0001994)2.81913207
46Recurrent skin infections (HP:0001581)2.79528656
47Tubular atrophy (HP:0000092)2.76741356
48Abnormality of polysaccharide metabolism (HP:0011012)2.73660401
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73660401
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73660401
51Gastrointestinal inflammation (HP:0004386)2.69650357
52Urinary glycosaminoglycan excretion (HP:0003541)2.68439868
53Mucopolysacchariduria (HP:0008155)2.68439868
54Recurrent bronchitis (HP:0002837)2.67606273
55Molar tooth sign on MRI (HP:0002419)2.65076457
56Abnormality of midbrain morphology (HP:0002418)2.65076457
57Squamous cell carcinoma (HP:0002860)2.63990559
58Basal cell carcinoma (HP:0002671)2.62551512
59Meningitis (HP:0001287)2.62550239
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61524999
61Gonadotropin excess (HP:0000837)2.61071306
62Recurrent viral infections (HP:0004429)2.58919212
63Increased hepatocellular lipid droplets (HP:0006565)2.57644658
64Impulsivity (HP:0100710)2.55815688
65Tubulointerstitial abnormality (HP:0001969)2.54710757
66Azoospermia (HP:0000027)2.53878741
67Mesangial abnormality (HP:0001966)2.51616747
68Acute lymphatic leukemia (HP:0006721)2.49142925
69Abnormality of the lower motor neuron (HP:0002366)2.48937326
70Cervical subluxation (HP:0003308)2.48728235
71Facial diplegia (HP:0001349)2.42091145
72Medial flaring of the eyebrow (HP:0010747)2.40070008
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39697870
74Mediastinal lymphadenopathy (HP:0100721)2.39629550
75Lipid accumulation in hepatocytes (HP:0006561)2.36709221
76Entropion (HP:0000621)2.32893383
77Ulnar bowing (HP:0003031)2.30492955
78Chronic obstructive pulmonary disease (HP:0006510)2.29003629
79Obstructive lung disease (HP:0006536)2.29003629
80Inflammation of the large intestine (HP:0002037)2.25726069
81Recurrent gram-negative bacterial infections (HP:0005420)2.24939871
82Progressive external ophthalmoplegia (HP:0000590)2.24628684
83Thin bony cortex (HP:0002753)2.20219219
84Exertional dyspnea (HP:0002875)2.15771949
85Dysostosis multiplex (HP:0000943)2.15248579
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.14324634
87Cholecystitis (HP:0001082)2.13539885
88Abnormal gallbladder physiology (HP:0012438)2.13539885
89Joint stiffness (HP:0001387)2.12102201
90Tubulointerstitial fibrosis (HP:0005576)2.11821956
91Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11269961
92External ophthalmoplegia (HP:0000544)2.09974464
93Fetal akinesia sequence (HP:0001989)2.06913890
94Amyotrophic lateral sclerosis (HP:0007354)2.06654618
95Epiphyseal stippling (HP:0010655)2.06264404
96Myopathic facies (HP:0002058)2.05834321
97Congenital stationary night blindness (HP:0007642)2.05710539
98Osteomyelitis (HP:0002754)2.02610741
99Postaxial foot polydactyly (HP:0001830)2.02131926
100Villous atrophy (HP:0011473)2.00611089
101Abnormality of small intestinal villus morphology (HP:0011472)2.00611089
102Aplasia of the musculature (HP:0100854)2.00566391
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3705007
104Absent/shortened dynein arms (HP:0200106)12.8005281
105Dynein arm defect of respiratory motile cilia (HP:0012255)12.8005281
106Fibular hypoplasia (HP:0003038)1.97982974
107Capillary hemangiomas (HP:0005306)1.97915276
108Clumsiness (HP:0002312)1.96605663
109Stage 5 chronic kidney disease (HP:0003774)1.95164936
110Muscle fiber atrophy (HP:0100295)1.93939957
111Pustule (HP:0200039)1.93655682
112Increased serum ferritin (HP:0003281)1.92706706
113Polydipsia (HP:0001959)1.92549222
114Abnormal drinking behavior (HP:0030082)1.92549222
115Abnormal rod and cone electroretinograms (HP:0008323)1.91885429
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91850461
117Abnormality of macrophages (HP:0004311)1.91200845
118Dyschromatopsia (HP:0007641)1.90655850
119Progressive microcephaly (HP:0000253)1.90265386
120Congenital hepatic fibrosis (HP:0002612)1.88034037
121Hypertensive crisis (HP:0100735)1.87709047
122Abnormality of the intrinsic pathway (HP:0010989)1.87310300
123Spastic tetraparesis (HP:0001285)1.85732761
124Hypercortisolism (HP:0001578)1.85578915
125Joint hemorrhage (HP:0005261)1.82847062
126Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81335846
127Verrucae (HP:0200043)1.81168882
128Papilloma (HP:0012740)1.81168882
129Abnormality of the renal cortex (HP:0011035)1.80985047
130Respiratory difficulties (HP:0002880)1.80397766
131Impaired proprioception (HP:0010831)1.80323246
132Turricephaly (HP:0000262)1.80026179
133Bony spicule pigmentary retinopathy (HP:0007737)1.79941293
134Recurrent pneumonia (HP:0006532)1.79132620
135Progressive neurologic deterioration (HP:0002344)1.77324448
136Prolonged partial thromboplastin time (HP:0003645)1.75885381
137Long clavicles (HP:0000890)1.74342987
138Oculomotor apraxia (HP:0000657)1.73060192
139Abnormal epiphyseal ossification (HP:0010656)1.72961849
140Choroideremia (HP:0001139)1.72674051
141Short ribs (HP:0000773)1.72049353
142Renal dysplasia (HP:0000110)1.66142386
143Decreased central vision (HP:0007663)1.65770840
144Abnormality of renal excretion (HP:0011036)1.63180113
145Abnormality of dentin (HP:0010299)1.60744383
146Bile duct proliferation (HP:0001408)1.58000958
147Abnormal biliary tract physiology (HP:0012439)1.58000958
148Heterotopia (HP:0002282)1.56442094
149Bell-shaped thorax (HP:0001591)1.54064987
150Absent frontal sinuses (HP:0002688)1.51566654
151Facial cleft (HP:0002006)1.51435882
152Abnormality of permanent molar morphology (HP:0011071)1.51177962
153Abnormality of the dental root (HP:0006486)1.51177962
154Taurodontia (HP:0000679)1.51177962
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50501436
156Absent epiphyses (HP:0010577)1.50501436
157Chronic sinusitis (HP:0011109)1.50435724
158Postaxial hand polydactyly (HP:0001162)1.48341084
159Deformed sella turcica (HP:0002681)1.48112424
160J-shaped sella turcica (HP:0002680)1.47948530
161Neurofibrillary tangles (HP:0002185)1.46236306
162Upper motor neuron abnormality (HP:0002127)1.45531113
163Hemorrhage of the eye (HP:0011885)1.41120033
164Abnormality of molar (HP:0011077)1.40964224
165Abnormality of molar morphology (HP:0011070)1.40964224
166Cystic liver disease (HP:0006706)1.40850105
167Double outlet right ventricle (HP:0001719)1.39755788
168Congenital malformation of the right heart (HP:0011723)1.39755788
169Microglossia (HP:0000171)1.39620367
170Abnormality of the dental pulp (HP:0006479)1.39239533
171Nephropathy (HP:0000112)1.38112421
172Abnormal urine output (HP:0012590)1.36387394
173Short femoral neck (HP:0100864)1.36307055
174Short thorax (HP:0010306)1.36198283
175Aplasia/Hypoplasia of the lens (HP:0008063)1.35760917
176Broad distal phalanx of finger (HP:0009836)1.33119893
177Loss of speech (HP:0002371)1.29608711
178Pancreatic fibrosis (HP:0100732)1.28342268
179Decreased electroretinogram (ERG) amplitude (HP:0000654)1.28330506
180Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.26886024
181Median cleft lip (HP:0000161)1.26046530
182Easy fatigability (HP:0003388)1.23646323
183Aplasia/Hypoplasia of the tongue (HP:0010295)1.23122451
184Cerebellar dysplasia (HP:0007033)1.22744151
185Supernumerary spleens (HP:0009799)1.22692934
186Exercise-induced myalgia (HP:0003738)1.22185651
187Polyuria (HP:0000103)1.20438028
188Short nail (HP:0001799)1.20081662
189Abnormality of ocular smooth pursuit (HP:0000617)1.19564729
190Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.18748427
191Asymmetric septal hypertrophy (HP:0001670)1.17518528
192Aplasia/Hypoplasia of the fibula (HP:0006492)1.17407795

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.38740498
2PDK38.38740498
3TESK16.22841404
4PDK25.51817286
5PRKD34.41854494
6ICK4.22063140
7ERN13.27592036
8BLK3.19909765
9TLK12.76511918
10MAP2K32.43696995
11PTK2B2.40136346
12TRIB32.26693344
13WNK42.25092114
14STK392.22237768
15TYK22.12344357
16GRK62.08779225
17DAPK11.90696220
18NEK21.84802574
19FLT31.83424106
20SMG11.82169565
21STK381.81420364
22PNCK1.74514860
23IRAK41.65141633
24BCKDK1.64950117
25RPS6KC11.60807159
26RPS6KL11.60807159
27TBK11.55658070
28KIT1.53868417
29MAPK121.49807094
30RPS6KA21.49735414
31MAP4K11.44627181
32RPS6KA61.44097575
33MAPK111.38713495
34DYRK1B1.36045072
35PIM21.33018564
36VRK21.32428642
37CDK41.28276971
38IKBKB1.19911987
39RPS6KA41.14883725
40PDK11.13600873
41IRAK31.11361427
42NME21.10497883
43MAPK151.09768036
44SYK1.04968244
45KDR1.02610169
46MAPKAPK31.02460860
47BTK0.99567909
48PRKD20.97427713
49DYRK30.96688074
50LMTK20.96491319
51SIK10.92853534
52CDK60.92344163
53TAF10.90683571
54PKN20.89601093
55WNK10.88249892
56HIPK20.86464870
57PIK3CG0.85260760
58IRAK10.83270513
59PRPF4B0.79894087
60MAPK40.79570678
61PASK0.79481981
62RPS6KB20.78444215
63TYRO30.77733711
64LYN0.77526756
65CCNB10.76799500
66CSNK1G30.74904396
67STK30.72560971
68MAP3K110.72398021
69TEC0.71823527
70RPS6KA50.69448220
71MAPK70.69303799
72BRD40.68872717
73PINK10.68346852
74IKBKE0.67185933
75MAPKAPK20.65377873
76PDPK10.64611144
77TTK0.64266279
78RIPK40.61950315
79CDK70.61922009
80PRKD10.61489389
81LCK0.58290456
82CSNK1G20.58010951
83EEF2K0.57171245
84MATK0.55710881
85CSNK1A1L0.54337847
86BMX0.53017418
87CHEK20.52674264
88TESK20.52363172
89IRAK20.50699023
90MAP2K40.50657659
91VRK10.49362600
92BMPR20.48853269
93MAPK100.47505946
94ABL20.46300492
95MAP2K20.45867752
96MAPK30.45004688
97CDC70.44387224
98CHEK10.41488087
99HCK0.41182158
100MAP2K60.40731915
101ATR0.39758855
102AKT20.39323736
103STK160.39008171
104PTK60.38404402
105MAPKAPK50.36839499
106STK38L0.35310164
107NTRK20.35037112
108CAMK1G0.34164444
109PAK10.32781138
110ATM0.30991650
111WEE10.30719279
112PRKCG0.30040134
113MUSK0.29629111
114MARK20.27532301
115MTOR0.23838312
116PRKAA10.23640511
117PRKG20.22245067
118PAK20.20943522
119CAMKK10.20324528
120MAP3K100.18348875
121RPS6KB10.17696622
122NEK60.16468150
123PLK10.15637864
124CSF1R0.14982055
125PAK40.14970066
126PRKCQ0.14742027
127CLK10.13766878
128PLK40.12909585
129PRKCZ0.12820340
130STK100.10496766
131BRSK20.09086111
132BMPR1B0.07539635
133MARK30.07502677
134CSNK2A10.07496789
135CDK150.07345594
136RPS6KA10.06743218
137CDK120.05746619
138BRAF0.05638031
139CDK180.04972295
140ZAP700.04728259
141BRSK10.03787872
142CDK11A0.03633683
143PRKG10.03295919
144GSK3B0.03263141
145YES10.03113105
146PIM10.02849816
147CDK10.02457288
148MAPK80.02336242
149PRKACG0.02174308
150EPHB10.01883164
151MAP3K50.01628459
152CDK20.01244841
153AURKA0.01029355
154PRKCD0.00893770
155PDGFRB0.00391132
156CAMK2A-0.0449738
157TAOK1-0.0433968
158PKN1-0.0433592
159PRKACB-0.0381015
160WNK3-0.0306948
161CSNK1D-0.0299623
162PRKDC-0.0218657
163CSNK2A2-0.0188777
164PRKCA-0.0130549
165MAP3K4-0.0121557
166PRKCB-0.0120246
167STK11-0.0086231
168EGFR-0.0077771
169CDK14-0.0048109

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.34982856
2Fatty acid biosynthesis_Homo sapiens_hsa000614.19288527
3Vitamin B6 metabolism_Homo sapiens_hsa007503.97710303
4Sulfur relay system_Homo sapiens_hsa041223.84460511
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.62480395
6Pyruvate metabolism_Homo sapiens_hsa006203.61301197
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.18621076
8Linoleic acid metabolism_Homo sapiens_hsa005913.06634432
9Base excision repair_Homo sapiens_hsa034102.77522798
10Glucagon signaling pathway_Homo sapiens_hsa049222.69436293
11Primary immunodeficiency_Homo sapiens_hsa053402.68172776
12Propanoate metabolism_Homo sapiens_hsa006402.67515528
13Basal transcription factors_Homo sapiens_hsa030222.58303073
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.41387726
15Selenocompound metabolism_Homo sapiens_hsa004502.37920082
16Other glycan degradation_Homo sapiens_hsa005112.32464883
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.24985543
18Carbohydrate digestion and absorption_Homo sapiens_hsa049732.20609036
19Pentose phosphate pathway_Homo sapiens_hsa000302.11828308
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08448089
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08270171
22Glycerolipid metabolism_Homo sapiens_hsa005611.98587011
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.95711259
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.89762773
25Dorso-ventral axis formation_Homo sapiens_hsa043201.88402259
26Fanconi anemia pathway_Homo sapiens_hsa034601.87773782
27DNA replication_Homo sapiens_hsa030301.83029404
28Non-homologous end-joining_Homo sapiens_hsa034501.77885304
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73709127
30PPAR signaling pathway_Homo sapiens_hsa033201.70611616
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.69741731
32Oocyte meiosis_Homo sapiens_hsa041141.68166635
33Asthma_Homo sapiens_hsa053101.67974421
34Leishmaniasis_Homo sapiens_hsa051401.65330920
35Fructose and mannose metabolism_Homo sapiens_hsa000511.61282840
36Acute myeloid leukemia_Homo sapiens_hsa052211.57288247
37Amphetamine addiction_Homo sapiens_hsa050311.56496721
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.56168453
39Allograft rejection_Homo sapiens_hsa053301.56016498
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.50385281
41Autoimmune thyroid disease_Homo sapiens_hsa053201.50171165
42Ether lipid metabolism_Homo sapiens_hsa005651.49859865
43Fat digestion and absorption_Homo sapiens_hsa049751.45077448
44Osteoclast differentiation_Homo sapiens_hsa043801.41201709
45Mineral absorption_Homo sapiens_hsa049781.41134371
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40172611
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34893197
48Herpes simplex infection_Homo sapiens_hsa051681.33992646
49mTOR signaling pathway_Homo sapiens_hsa041501.31652297
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28326332
51Carbon metabolism_Homo sapiens_hsa012001.27987298
52Graft-versus-host disease_Homo sapiens_hsa053321.26140211
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.25032008
54Non-small cell lung cancer_Homo sapiens_hsa052231.22723509
55Hematopoietic cell lineage_Homo sapiens_hsa046401.22416468
56Cardiac muscle contraction_Homo sapiens_hsa042601.22277624
57Huntingtons disease_Homo sapiens_hsa050161.21296236
58Renin secretion_Homo sapiens_hsa049241.19633790
59Fatty acid metabolism_Homo sapiens_hsa012121.17718443
60Antigen processing and presentation_Homo sapiens_hsa046121.16118184
61Fatty acid degradation_Homo sapiens_hsa000711.14297140
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13973886
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13080133
64mRNA surveillance pathway_Homo sapiens_hsa030151.04392595
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04214297
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03137479
67Tuberculosis_Homo sapiens_hsa051521.02907535
68Type I diabetes mellitus_Homo sapiens_hsa049401.01821406
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01612781
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99267007
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97816883
72Glutathione metabolism_Homo sapiens_hsa004800.97641443
73Purine metabolism_Homo sapiens_hsa002300.97100680
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95410865
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94889189
76Nucleotide excision repair_Homo sapiens_hsa034200.93884707
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93580656
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92083569
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89454548
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.88235679
81Systemic lupus erythematosus_Homo sapiens_hsa053220.87948002
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87927333
83Lysosome_Homo sapiens_hsa041420.87486742
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86288997
85HTLV-I infection_Homo sapiens_hsa051660.85622418
86Epstein-Barr virus infection_Homo sapiens_hsa051690.84325463
87Chronic myeloid leukemia_Homo sapiens_hsa052200.83876894
88Arachidonic acid metabolism_Homo sapiens_hsa005900.82469384
89ABC transporters_Homo sapiens_hsa020100.79923737
90Chemical carcinogenesis_Homo sapiens_hsa052040.79109275
91RNA transport_Homo sapiens_hsa030130.78711811
92Ribosome_Homo sapiens_hsa030100.78593990
93Toxoplasmosis_Homo sapiens_hsa051450.77614252
94Measles_Homo sapiens_hsa051620.77317452
95Vitamin digestion and absorption_Homo sapiens_hsa049770.76737728
96Notch signaling pathway_Homo sapiens_hsa043300.76506663
97Sphingolipid metabolism_Homo sapiens_hsa006000.76244793
98Biosynthesis of amino acids_Homo sapiens_hsa012300.74575130
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74014708
100Hedgehog signaling pathway_Homo sapiens_hsa043400.73141330
101Hepatitis B_Homo sapiens_hsa051610.70510905
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.70164410
103Legionellosis_Homo sapiens_hsa051340.70137643
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70092357
105Platelet activation_Homo sapiens_hsa046110.69188186
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69035157
107Estrogen signaling pathway_Homo sapiens_hsa049150.67356659
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.66563547
109Long-term potentiation_Homo sapiens_hsa047200.66427236
110Staphylococcus aureus infection_Homo sapiens_hsa051500.64834882
111Collecting duct acid secretion_Homo sapiens_hsa049660.64089908
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62216363
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62093873
114Pancreatic cancer_Homo sapiens_hsa052120.61393586
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.59416073
116Renin-angiotensin system_Homo sapiens_hsa046140.59207275
117Hepatitis C_Homo sapiens_hsa051600.58108141
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.56307593
119T cell receptor signaling pathway_Homo sapiens_hsa046600.55019533
120Insulin secretion_Homo sapiens_hsa049110.54894088
121Bile secretion_Homo sapiens_hsa049760.54494283
122One carbon pool by folate_Homo sapiens_hsa006700.54012707
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53723804
124Viral myocarditis_Homo sapiens_hsa054160.52373861
125African trypanosomiasis_Homo sapiens_hsa051430.50556338
126Insulin resistance_Homo sapiens_hsa049310.48627935
127Thyroid hormone synthesis_Homo sapiens_hsa049180.47056627
128Bladder cancer_Homo sapiens_hsa052190.45844810
129AMPK signaling pathway_Homo sapiens_hsa041520.45710343
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.45253334
131Alcoholism_Homo sapiens_hsa050340.44253777
132VEGF signaling pathway_Homo sapiens_hsa043700.43423894
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43405555
134Endocytosis_Homo sapiens_hsa041440.42960297
135Rheumatoid arthritis_Homo sapiens_hsa053230.42054060
136TNF signaling pathway_Homo sapiens_hsa046680.41975585
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41354712
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40218241
139Pancreatic secretion_Homo sapiens_hsa049720.39123729
140Calcium signaling pathway_Homo sapiens_hsa040200.38843707
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38812842
142Lysine degradation_Homo sapiens_hsa003100.37267033
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.36887124
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36040284
145Metabolic pathways_Homo sapiens_hsa011000.35834175
146Cell cycle_Homo sapiens_hsa041100.35703815
147RNA polymerase_Homo sapiens_hsa030200.35424430
148Pyrimidine metabolism_Homo sapiens_hsa002400.34622737
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31292489
150Inositol phosphate metabolism_Homo sapiens_hsa005620.31075661
151Sulfur metabolism_Homo sapiens_hsa009200.30813738
152Protein digestion and absorption_Homo sapiens_hsa049740.27944363
153Salivary secretion_Homo sapiens_hsa049700.27454743
154B cell receptor signaling pathway_Homo sapiens_hsa046620.27166330
155Salmonella infection_Homo sapiens_hsa051320.27165226
156Gastric acid secretion_Homo sapiens_hsa049710.23689825
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23077156
158N-Glycan biosynthesis_Homo sapiens_hsa005100.21973202
159cAMP signaling pathway_Homo sapiens_hsa040240.21907814
160Viral carcinogenesis_Homo sapiens_hsa052030.19702895
161Taste transduction_Homo sapiens_hsa047420.19168637
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18857339
163RNA degradation_Homo sapiens_hsa030180.18346263
164Retinol metabolism_Homo sapiens_hsa008300.18273949
165Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18199733
166Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16420764
167Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15027502
168Homologous recombination_Homo sapiens_hsa034400.12097482
169Wnt signaling pathway_Homo sapiens_hsa043100.11912864
170Influenza A_Homo sapiens_hsa051640.11796108
171Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11710498
172Synaptic vesicle cycle_Homo sapiens_hsa047210.11452554

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