TEX261

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hypotonic response (GO:0006971)4.95480871
2L-phenylalanine metabolic process (GO:0006558)4.91627953
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.91627953
4L-phenylalanine catabolic process (GO:0006559)4.72334361
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.72334361
6alpha-linolenic acid metabolic process (GO:0036109)4.37992358
7regulation of response to osmotic stress (GO:0047484)4.20731002
8protein localization to endosome (GO:0036010)4.18597687
9valine metabolic process (GO:0006573)4.18019440
10lysine catabolic process (GO:0006554)4.12838942
11lysine metabolic process (GO:0006553)4.12838942
12aromatic amino acid family catabolic process (GO:0009074)4.12529394
13regulation of triglyceride catabolic process (GO:0010896)4.11433043
14sulfur amino acid catabolic process (GO:0000098)4.10695731
15ethanol oxidation (GO:0006069)4.07341796
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95763251
17glyoxylate metabolic process (GO:0046487)3.95377896
18skin morphogenesis (GO:0043589)3.89291323
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.86544199
20kynurenine metabolic process (GO:0070189)3.81511196
21cysteine metabolic process (GO:0006534)3.79277710
22protein retention in ER lumen (GO:0006621)3.75384424
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74757735
24tryptophan catabolic process (GO:0006569)3.72824257
25indole-containing compound catabolic process (GO:0042436)3.72824257
26indolalkylamine catabolic process (GO:0046218)3.72824257
27amino-acid betaine metabolic process (GO:0006577)3.70019770
28barbed-end actin filament capping (GO:0051016)3.65436906
29regulation of early endosome to late endosome transport (GO:2000641)3.61849826
30negative regulation of erythrocyte differentiation (GO:0045647)3.61059564
31peptidyl-glutamic acid carboxylation (GO:0017187)3.52885194
32protein carboxylation (GO:0018214)3.52885194
33tryptophan metabolic process (GO:0006568)3.52211460
34COPI coating of Golgi vesicle (GO:0048205)3.48121325
35Golgi transport vesicle coating (GO:0048200)3.48121325
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.47903383
37glycine metabolic process (GO:0006544)3.46094405
38positive regulation of triglyceride biosynthetic process (GO:0010867)3.44776547
39serine family amino acid biosynthetic process (GO:0009070)3.44689882
402-oxoglutarate metabolic process (GO:0006103)3.40856031
41tricarboxylic acid metabolic process (GO:0072350)3.38962992
42cell-substrate adherens junction assembly (GO:0007045)3.38901988
43focal adhesion assembly (GO:0048041)3.38901988
44cell-substrate junction assembly (GO:0007044)3.38860103
45fatty acid beta-oxidation (GO:0006635)3.38840146
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.38578661
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38578661
48positive regulation of triglyceride metabolic process (GO:0090208)3.37513962
49negative regulation of fibrinolysis (GO:0051918)3.36708604
50bile acid biosynthetic process (GO:0006699)3.35541298
51pinocytosis (GO:0006907)3.34784022
52stress fiber assembly (GO:0043149)3.31775242
53adherens junction assembly (GO:0034333)3.29760864
54positive regulation of extracellular matrix organization (GO:1903055)3.29411979
55regulation of extracellular matrix disassembly (GO:0010715)3.27758960
56aldehyde catabolic process (GO:0046185)3.25403742
57branched-chain amino acid catabolic process (GO:0009083)3.22405538
58carnitine metabolic process (GO:0009437)3.22350267
59branched-chain amino acid metabolic process (GO:0009081)3.22130181
60high-density lipoprotein particle remodeling (GO:0034375)3.20260085
61fatty acid oxidation (GO:0019395)3.16984468
62cellular modified amino acid catabolic process (GO:0042219)3.16711250
63complement activation, alternative pathway (GO:0006957)3.14965292
64basement membrane organization (GO:0071711)3.14931130
65activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.13545491
66serine family amino acid metabolic process (GO:0009069)3.13371463
67aromatic amino acid family metabolic process (GO:0009072)3.12651171
68negative regulation of fatty acid transport (GO:2000192)3.12387140
69lipid oxidation (GO:0034440)3.12164138
704-hydroxyproline metabolic process (GO:0019471)3.11920825
71homocysteine metabolic process (GO:0050667)3.10286114
72serine family amino acid catabolic process (GO:0009071)3.09651144
73regulation of cholesterol esterification (GO:0010872)3.08937304
74ethanol metabolic process (GO:0006067)3.08061372
75plasma lipoprotein particle clearance (GO:0034381)3.07696388
76fatty acid catabolic process (GO:0009062)3.07614126
77pentose-phosphate shunt (GO:0006098)3.07368266
78cell volume homeostasis (GO:0006884)3.05831619
79regulation of cholesterol metabolic process (GO:0090181)3.03442439
80reverse cholesterol transport (GO:0043691)3.03432580
81regulation of triglyceride metabolic process (GO:0090207)3.03406907
82primary alcohol catabolic process (GO:0034310)3.02738195
83positive regulation of nuclease activity (GO:0032075)3.01896798
84L-serine metabolic process (GO:0006563)3.00256137
85vesicle coating (GO:0006901)2.99851890
86proline biosynthetic process (GO:0006561)2.99549242
87biotin metabolic process (GO:0006768)2.98177823
88plasma lipoprotein particle remodeling (GO:0034369)2.97776752
89protein-lipid complex remodeling (GO:0034368)2.97776752
90macromolecular complex remodeling (GO:0034367)2.97776752
91mannose metabolic process (GO:0006013)2.97431354
92tyrosine metabolic process (GO:0006570)2.97131874
93regulation of fibrinolysis (GO:0051917)2.96025222
94aspartate family amino acid catabolic process (GO:0009068)2.95352521
95alpha-amino acid catabolic process (GO:1901606)2.94397660
96short-chain fatty acid metabolic process (GO:0046459)2.93290152
97response to nitrosative stress (GO:0051409)2.92643040
98NADPH regeneration (GO:0006740)2.91502883
99regulation of glucose import in response to insulin stimulus (GO:2001273)2.91433021
100positive regulation of blood vessel endothelial cell migration (GO:0043536)2.91188078
101regulation of NFAT protein import into nucleus (GO:0051532)2.89612601
102regulation of cholesterol homeostasis (GO:2000188)2.88921792
103regulation of cholesterol biosynthetic process (GO:0045540)2.88499354
104urea metabolic process (GO:0019627)2.88474406
105urea cycle (GO:0000050)2.88474406
106regulation of protein activation cascade (GO:2000257)2.87928069
107plasma lipoprotein particle assembly (GO:0034377)2.87902568
108monocarboxylic acid catabolic process (GO:0072329)2.87630524
109apoptotic cell clearance (GO:0043277)2.87488851
110cortical cytoskeleton organization (GO:0030865)2.85883307
111cellular ketone body metabolic process (GO:0046950)2.85627194
112positive regulation of receptor recycling (GO:0001921)2.84377746
113phospholipid efflux (GO:0033700)2.84322662
114negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.81923876
115hemidesmosome assembly (GO:0031581)2.81443813
116nitrogen cycle metabolic process (GO:0071941)2.81294703
117regulation of triglyceride biosynthetic process (GO:0010866)2.80732239
118cellular amino acid catabolic process (GO:0009063)2.79659146
119endoplasmic reticulum unfolded protein response (GO:0030968)2.79372211
120modulation by symbiont of host cellular process (GO:0044068)2.78279297
121low-density lipoprotein particle remodeling (GO:0034374)2.77943209
122maternal placenta development (GO:0001893)2.77765784
123negative regulation of cell size (GO:0045792)2.77645391
124negative regulation of sterol transport (GO:0032372)2.76887076
125negative regulation of cholesterol transport (GO:0032375)2.76887076
126regulation of complement activation (GO:0030449)2.76303029
127bile acid metabolic process (GO:0008206)2.75623344
128spliceosomal tri-snRNP complex assembly (GO:0000244)2.74023490
129carboxylic acid catabolic process (GO:0046395)2.73706444
130organic acid catabolic process (GO:0016054)2.73706444
131hyaluronan catabolic process (GO:0030214)2.71036205
132cell adhesion mediated by integrin (GO:0033627)2.68690469
133positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67910017
134low-density lipoprotein particle clearance (GO:0034383)2.67902597
135antigen processing and presentation of endogenous antigen (GO:0019883)2.67694679
136COPII vesicle coating (GO:0048208)2.67167437
137drug transmembrane transport (GO:0006855)2.66847215
138response to laminar fluid shear stress (GO:0034616)2.66641238
139ketone body metabolic process (GO:1902224)2.65742979
140acylglycerol homeostasis (GO:0055090)2.65640446
141triglyceride homeostasis (GO:0070328)2.65640446
142regulation of nuclease activity (GO:0032069)2.65435446
143ER-nucleus signaling pathway (GO:0006984)2.65327708
144embryonic process involved in female pregnancy (GO:0060136)2.64410361
145protein-lipid complex assembly (GO:0065005)2.63621745
146acetyl-CoA metabolic process (GO:0006084)2.63323745
147positive regulation of triglyceride lipase activity (GO:0061365)2.62761410
148positive regulation of lipoprotein lipase activity (GO:0051006)2.62761410
149epithelial cell-cell adhesion (GO:0090136)2.60338510
150regulation of extracellular matrix organization (GO:1903053)2.58346937
151cellular response to unfolded protein (GO:0034620)2.56609644
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.54659919
153regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53940122
154desmosome organization (GO:0002934)2.53836894
155protein maturation by protein folding (GO:0022417)2.53679456
156negative regulation of protein localization to plasma membrane (GO:1903077)2.52764258
157apoptotic process involved in morphogenesis (GO:0060561)2.50566525
158regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.48583107
159regulation of histone H3-K27 methylation (GO:0061085)2.48572273
160glucose catabolic process (GO:0006007)2.46360152
161regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.45868817
162modulation by virus of host morphology or physiology (GO:0019048)2.45373947
163NADH metabolic process (GO:0006734)2.44526235
164embryo implantation (GO:0007566)2.43816254
165peptidyl-proline hydroxylation (GO:0019511)2.42091793
166membrane protein ectodomain proteolysis (GO:0006509)2.41247223
167cytoskeletal anchoring at plasma membrane (GO:0007016)2.39694451
168positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.39367748
169modulation by virus of host process (GO:0019054)2.37844658
170endodermal cell differentiation (GO:0035987)2.37815039
171protein hydroxylation (GO:0018126)2.37660350
172cellular response to osmotic stress (GO:0071470)2.37389611
173protein targeting to plasma membrane (GO:0072661)2.37261563
174proline metabolic process (GO:0006560)2.36366429
175sodium ion export (GO:0071436)2.36220034
176activation of Rac GTPase activity (GO:0032863)2.34873918
177vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34594898
178adhesion of symbiont to host (GO:0044406)2.33482905
179cellular response to topologically incorrect protein (GO:0035967)2.32669557
180positive regulation of protein dephosphorylation (GO:0035307)2.32641447
181endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.31188523
182cortical actin cytoskeleton organization (GO:0030866)2.31128049
183positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.26601573
184glucose 6-phosphate metabolic process (GO:0051156)2.25823839
185membrane raft organization (GO:0031579)2.25580461
186mitotic chromosome condensation (GO:0007076)2.25412785
187branching involved in mammary gland duct morphogenesis (GO:0060444)2.22060969
188regulation of nucleobase-containing compound transport (GO:0032239)2.20841586
189regulation of plasminogen activation (GO:0010755)2.20734036
190planar cell polarity pathway involved in neural tube closure (GO:0090179)2.20348998
191positive regulation of myotube differentiation (GO:0010831)2.20213564
192hyaluronan metabolic process (GO:0030212)2.18701488
193substrate-dependent cell migration (GO:0006929)2.16845480

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.72612869
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.31701998
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.00227026
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.80845526
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.29022039
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.94546226
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.74342474
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74176164
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.59512359
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.26566591
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21212297
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.18281929
13ZNF263_19887448_ChIP-Seq_K562_Human2.09777881
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03829778
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99123222
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.96007540
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91269226
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85931902
19TCF7_22412390_ChIP-Seq_EML_Mouse1.81418518
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75367204
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.73740418
22VDR_21846776_ChIP-Seq_THP-1_Human1.73617415
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72329782
24KDM2B_26808549_Chip-Seq_DND41_Human1.70417734
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.69672965
26KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68774596
27P300_27058665_Chip-Seq_ZR-75-30cells_Human1.67695317
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.65017809
29GATA1_22025678_ChIP-Seq_K562_Human1.64691625
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61791218
31MYC_22102868_ChIP-Seq_BL_Human1.60212320
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59999386
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59489893
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58096719
35* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55961295
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52795759
37KDM2B_26808549_Chip-Seq_K562_Human1.50415624
38* CLOCK_20551151_ChIP-Seq_293T_Human1.49284631
39ATF3_27146783_Chip-Seq_COLON_Human1.47886504
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47632236
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47572850
42SCL_19346495_ChIP-Seq_HPC-7_Human1.46845216
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46243285
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46196972
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43993253
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42698082
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42463633
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42218644
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40243465
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40154126
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.39127434
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38317704
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38136912
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37965768
55TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36264708
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36142056
57TP53_22127205_ChIP-Seq_IMR90_Human1.35967235
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35740528
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33933167
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.33471660
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32647332
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31001244
63MAF_26560356_Chip-Seq_TH1_Human1.30853861
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30496857
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30220333
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27676891
67LXR_22292898_ChIP-Seq_THP-1_Human1.26708683
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25448325
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25289284
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24078800
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23942649
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.23499197
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.23386025
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23309416
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22476818
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22386360
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.22315264
78SPI1_23547873_ChIP-Seq_NB4_Human1.21690889
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21160002
80UTX_26944678_Chip-Seq_JUKART_Human1.18688959
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18389980
82* ELK3_25401928_ChIP-Seq_HUVEC_Human1.17592709
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.16936886
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.16936886
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16895245
86VDR_24763502_ChIP-Seq_THP-1_Human1.16648993
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16544078
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16445564
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.16257611
90NCOR1_26117541_ChIP-Seq_K562_Human1.16157676
91NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15191615
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15046991
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14795860
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14773968
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14146837
96* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13625194
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13190523
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.13020240
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12562359
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.11989309
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.11097635
102E2F7_22180533_ChIP-Seq_HELA_Human1.10797374
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.09872848
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09517887
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09083391
106CREB1_26743006_Chip-Seq_LNCaP_Human1.08824499
107MYB_26560356_Chip-Seq_TH2_Human1.08718509
108IRF8_27001747_Chip-Seq_BMDM_Mouse1.08522689
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.08244771
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.08214835
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06909613
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06640043
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06448119
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.05631607
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05293502
116CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04430057
117MAF_26560356_Chip-Seq_TH2_Human1.04330712
118ETS1_20019798_ChIP-Seq_JURKAT_Human1.04205092
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03729465
120SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03729465
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03573413
122MYB_26560356_Chip-Seq_TH1_Human1.03520885
123GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03067937
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02749329
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02681385
126SMC4_20622854_ChIP-Seq_HELA_Human1.02549657
127RUNX1_27514584_Chip-Seq_MCF-7_Human1.01751118
128* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01521133
129EST1_17652178_ChIP-ChIP_JURKAT_Human0.99934524
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99822745
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99731474
132EGR1_19374776_ChIP-ChIP_THP-1_Human0.99600708
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99041415
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98853447
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98675139
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97516959
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97119768
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96481617
139P68_20966046_ChIP-Seq_HELA_Human0.96457816
140E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96128452
141XRN2_22483619_ChIP-Seq_HELA_Human0.95932047
142THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95340990
143* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95109068
144IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93888136
145RACK7_27058665_Chip-Seq_MCF-7_Human0.93120179
146CTCF_26484167_Chip-Seq_Bcells_Mouse0.93037092
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92508759
148PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92010791
149* GABP_19822575_ChIP-Seq_HepG2_Human0.92008769
150FOXP3_21729870_ChIP-Seq_TREG_Human0.91991616
151DCP1A_22483619_ChIP-Seq_HELA_Human0.91252864
152BCL6_27268052_Chip-Seq_Bcells_Human0.91119509
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90906235
154TFEB_21752829_ChIP-Seq_HELA_Human0.90863858
155AR_21909140_ChIP-Seq_LNCAP_Human0.90726349
156SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90505942
157CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90388145
158PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89962560
159BCOR_27268052_Chip-Seq_Bcells_Human0.88874114
160SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88590906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.34036560
2MP0005360_urolithiasis4.15442038
3MP0009840_abnormal_foam_cell3.53842108
4MP0005365_abnormal_bile_salt3.35772036
5MP0003806_abnormal_nucleotide_metabolis3.23844588
6MP0005085_abnormal_gallbladder_physiolo3.19342731
7MP0002877_abnormal_melanocyte_morpholog2.56013458
8MP0003191_abnormal_cellular_cholesterol2.50394555
9MP0008875_abnormal_xenobiotic_pharmacok2.41677657
10MP0003252_abnormal_bile_duct2.40500421
11MP0010329_abnormal_lipoprotein_level2.26042448
12MP0005083_abnormal_biliary_tract2.25755048
13MP0003705_abnormal_hypodermis_morpholog2.16011150
14MP0005058_abnormal_lysosome_morphology2.15202754
15MP0001666_abnormal_nutrient_absorption2.10423183
16MP0004272_abnormal_basement_membrane2.05718799
17MP0003300_gastrointestinal_ulcer2.04563772
18MP0005257_abnormal_intraocular_pressure1.99756170
19MP0008260_abnormal_autophagy1.99426571
20MP0005332_abnormal_amino_acid1.99097800
21MP0003091_abnormal_cell_migration1.95786046
22MP0003186_abnormal_redox_activity1.93283758
23MP0001958_emphysema1.87720614
24MP0005670_abnormal_white_adipose1.82723182
25MP0001849_ear_inflammation1.77919837
26MP0003436_decreased_susceptibility_to1.76291451
27MP0005076_abnormal_cell_differentiation1.76183237
28MP0000609_abnormal_liver_physiology1.74662446
29MP0006054_spinal_hemorrhage1.72800400
30MP0004233_abnormal_muscle_weight1.72421928
31MP0003656_abnormal_erythrocyte_physiolo1.71457528
32MP0010234_abnormal_vibrissa_follicle1.68622810
33MP0003195_calcinosis1.64059596
34MP0003950_abnormal_plasma_membrane1.62787252
35MP0005275_abnormal_skin_tensile1.62746585
36MP0004858_abnormal_nervous_system1.62061422
37MP0008438_abnormal_cutaneous_collagen1.61949460
38MP0009643_abnormal_urine_homeostasis1.59838609
39MP0003011_delayed_dark_adaptation1.56838123
40MP0009278_abnormal_bone_marrow1.51943759
41MP0000751_myopathy1.51738484
42MP0002118_abnormal_lipid_homeostasis1.50594857
43MP0005409_darkened_coat_color1.49375359
44MP0005319_abnormal_enzyme/_coenzyme1.48724631
45MP0002060_abnormal_skin_morphology1.47842733
46MP0005623_abnormal_meninges_morphology1.47614059
47MP0002138_abnormal_hepatobiliary_system1.45704109
48MP0001853_heart_inflammation1.41762111
49MP0010368_abnormal_lymphatic_system1.40790683
50MP0003453_abnormal_keratinocyte_physiol1.40628506
51MP0001835_abnormal_antigen_presentation1.38838153
52MP0005464_abnormal_platelet_physiology1.33724394
53MP0005584_abnormal_enzyme/coenzyme_acti1.32793392
54MP0000678_abnormal_parathyroid_gland1.31280711
55MP0000733_abnormal_muscle_development1.30961563
56MP0001348_abnormal_lacrimal_gland1.27757395
57MP0001764_abnormal_homeostasis1.27649219
58MP0000767_abnormal_smooth_muscle1.27110020
59MP0004019_abnormal_vitamin_homeostasis1.25684076
60MP0005503_abnormal_tendon_morphology1.23583742
61MP0008469_abnormal_protein_level1.23311988
62MP0000685_abnormal_immune_system1.23073986
63MP0005220_abnormal_exocrine_pancreas1.21320539
64MP0002396_abnormal_hematopoietic_system1.19788119
65MP0003279_aneurysm1.18582003
66MP0000759_abnormal_skeletal_muscle1.17860459
67MP0002796_impaired_skin_barrier1.17215981
68MP0000598_abnormal_liver_morphology1.15714897
69MP0004130_abnormal_muscle_cell1.15426814
70MP0000003_abnormal_adipose_tissue1.15023496
71MP0002896_abnormal_bone_mineralization1.14884680
72MP0004087_abnormal_muscle_fiber1.14372366
73MP0005666_abnormal_adipose_tissue1.12338660
74MP0003303_peritoneal_inflammation1.11561669
75MP0002419_abnormal_innate_immunity1.10808726
76MP0001915_intracranial_hemorrhage1.09366090
77MP0009333_abnormal_splenocyte_physiolog1.08684156
78MP0006036_abnormal_mitochondrial_physio1.07679341
79MP0003724_increased_susceptibility_to1.06704379
80MP0000747_muscle_weakness1.06629713
81MP0005408_hypopigmentation1.06287967
82MP0009785_altered_susceptibility_to1.03885178
83MP0009763_increased_sensitivity_to1.02495801
84MP0003763_abnormal_thymus_physiology1.02262545
85MP0000467_abnormal_esophagus_morphology1.01739880
86MP0005025_abnormal_response_to1.00882712
87MP0005330_cardiomyopathy0.99475580
88MP0002933_joint_inflammation0.98916190
89MP0002998_abnormal_bone_remodeling0.98793243
90MP0001533_abnormal_skeleton_physiology0.96349436
91MP0001730_embryonic_growth_arrest0.95613552
92MP0000858_altered_metastatic_potential0.94907118
93MP0005387_immune_system_phenotype0.94601799
94MP0001790_abnormal_immune_system0.94601799
95MP0001845_abnormal_inflammatory_respons0.94059114
96MP0001542_abnormal_bone_strength0.93660390
97MP0009384_cardiac_valve_regurgitation0.93616756
98MP0005636_abnormal_mineral_homeostasis0.92995633
99MP0003828_pulmonary_edema0.92748572
100MP0005621_abnormal_cell_physiology0.92512568
101MP0005501_abnormal_skin_physiology0.92490628
102MP0010630_abnormal_cardiac_muscle0.91782870
103MP0005451_abnormal_body_composition0.90951269
104MP0005671_abnormal_response_to0.90652879
105MP0004808_abnormal_hematopoietic_stem0.90347074
106MP0003868_abnormal_feces_composition0.89942584
107MP0002089_abnormal_postnatal_growth/wei0.89593069
108MP0000343_altered_response_to0.89459053
109MP0009780_abnormal_chondrocyte_physiolo0.87439514
110MP0003329_amyloid_beta_deposits0.87325098
111MP0003172_abnormal_lysosome_physiology0.87253970
112MP0006138_congestive_heart_failure0.87026887
113MP0009379_abnormal_foot_pigmentation0.86574613
114MP0003221_abnormal_cardiomyocyte_apopto0.86153392
115MP0009053_abnormal_anal_canal0.86008287
116MP0001756_abnormal_urination0.85365643
117MP0000689_abnormal_spleen_morphology0.84391476
118MP0005000_abnormal_immune_tolerance0.83952579
119MP0002166_altered_tumor_susceptibility0.83660942
120MP0004147_increased_porphyrin_level0.83419998
121MP0003448_altered_tumor_morphology0.83101566
122MP0000465_gastrointestinal_hemorrhage0.81408834
123MP0010155_abnormal_intestine_physiology0.81183377
124MP0001800_abnormal_humoral_immune0.81166539
125MP0002136_abnormal_kidney_physiology0.81143009
126MP0000749_muscle_degeneration0.80790273
127MP0005397_hematopoietic_system_phenotyp0.80662029
128MP0001545_abnormal_hematopoietic_system0.80662029
129MP0009642_abnormal_blood_homeostasis0.80390647
130MP0006082_CNS_inflammation0.80369491
131MP0003075_altered_response_to0.80016790
132MP0000681_abnormal_thyroid_gland0.79638086
133MP0004036_abnormal_muscle_relaxation0.79569810
134MP0000604_amyloidosis0.79093320
135MP0005023_abnormal_wound_healing0.78988580
136MP0002452_abnormal_antigen_presenting0.78963308
137MP0004084_abnormal_cardiac_muscle0.78151278
138MP0001216_abnormal_epidermal_layer0.77995764
139MP0003566_abnormal_cell_adhesion0.77745122
140MP0004185_abnormal_adipocyte_glucose0.76867115
141MP0002970_abnormal_white_adipose0.76633300
142MP0005334_abnormal_fat_pad0.76064016
143MP0000750_abnormal_muscle_regeneration0.75595448
144MP0002722_abnormal_immune_system0.75339520
145MP0002723_abnormal_immune_serum0.75221743
146MP0003795_abnormal_bone_structure0.75008832
147MP0002269_muscular_atrophy0.75003936
148MP0005375_adipose_tissue_phenotype0.74141807
149MP0000490_abnormal_crypts_of0.74090315
150MP0002971_abnormal_brown_adipose0.74024279
151MP0004510_myositis0.73712124
152MP0004947_skin_inflammation0.73539235
153MP0005164_abnormal_response_to0.73023720
154MP0002405_respiratory_system_inflammati0.72891292
155MP0002837_dystrophic_cardiac_calcinosis0.72678482
156MP0002420_abnormal_adaptive_immunity0.72057971
157MP0002078_abnormal_glucose_homeostasis0.71857692
158MP0005165_increased_susceptibility_to0.71601597
159MP0002132_abnormal_respiratory_system0.71462371
160MP0001243_abnormal_dermal_layer0.71078169
161MP0000249_abnormal_blood_vessel0.70938186
162MP0009115_abnormal_fat_cell0.70371875
163MP0009931_abnormal_skin_appearance0.70253189
164MP0005508_abnormal_skeleton_morphology0.70248676
165MP0010352_gastrointestinal_tract_polyps0.69933501
166MP0005390_skeleton_phenotype0.69895858
167MP0009764_decreased_sensitivity_to0.69320684

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.53800852
2Xanthomatosis (HP:0000991)4.08110408
3Premature rupture of membranes (HP:0001788)4.00186569
4Hypoglycemic coma (HP:0001325)3.88927659
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.85534373
6Distal lower limb muscle weakness (HP:0009053)3.84397648
7Intrahepatic cholestasis (HP:0001406)3.81697653
8Deep venous thrombosis (HP:0002625)3.74473104
9Ketosis (HP:0001946)3.54526706
10Hyperammonemia (HP:0001987)3.53350479
11Flat acetabular roof (HP:0003180)3.49892944
12Upper limb amyotrophy (HP:0009129)3.39387368
13Distal upper limb amyotrophy (HP:0007149)3.39387368
14Achilles tendon contracture (HP:0001771)3.34570375
15Hyperglycinuria (HP:0003108)3.34465136
16Ketoacidosis (HP:0001993)3.33432619
17Vertebral compression fractures (HP:0002953)3.32159680
18Hand muscle atrophy (HP:0009130)3.15244130
19Complement deficiency (HP:0004431)3.15227368
20Obstructive sleep apnea (HP:0002870)3.11456999
21Abnormality of the Achilles tendon (HP:0005109)3.10673207
22Abnormality of fatty-acid metabolism (HP:0004359)3.09233013
23Abnormality of the common coagulation pathway (HP:0010990)3.03360068
24Hyperlipoproteinemia (HP:0010980)2.99046113
25Abnormality of serine family amino acid metabolism (HP:0010894)2.97795638
26Abnormality of glycine metabolism (HP:0010895)2.97795638
27Prolonged partial thromboplastin time (HP:0003645)2.97005115
28Abnormality of the distal phalanges of the toes (HP:0010182)2.88934800
29Hypoalphalipoproteinemia (HP:0003233)2.87439907
30Systemic lupus erythematosus (HP:0002725)2.87124129
31Vacuolated lymphocytes (HP:0001922)2.86561050
32Hypobetalipoproteinemia (HP:0003563)2.85159257
33Dicarboxylic aciduria (HP:0003215)2.80828898
34Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80828898
35Stridor (HP:0010307)2.79484844
36Generalized aminoaciduria (HP:0002909)2.78066794
37Abnormality of the intrinsic pathway (HP:0010989)2.77962243
38Abnormality of complement system (HP:0005339)2.77547479
39Spinal rigidity (HP:0003306)2.75105035
40Abnormality of carpal bone ossification (HP:0006257)2.74016804
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.73478892
42Increased connective tissue (HP:0009025)2.72290928
43Hypolipoproteinemia (HP:0010981)2.72233280
44Dysostosis multiplex (HP:0000943)2.68422250
45Urinary glycosaminoglycan excretion (HP:0003541)2.67208352
46Mucopolysacchariduria (HP:0008155)2.67208352
47Joint hemorrhage (HP:0005261)2.62656417
48Axonal loss (HP:0003447)2.61854194
49Spinal cord compression (HP:0002176)2.61149445
50Late onset (HP:0003584)2.60492801
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.59594284
52Myocardial infarction (HP:0001658)2.59159767
53Vascular tortuosity (HP:0004948)2.58418962
54Increased variability in muscle fiber diameter (HP:0003557)2.50316416
55Hyperglycinemia (HP:0002154)2.49690779
56Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46903393
57Muscle fiber splitting (HP:0003555)2.46817282
58Abnormality of skeletal muscle fiber size (HP:0012084)2.46630049
59Hyperacusis (HP:0010780)2.46621108
60Arterial tortuosity (HP:0005116)2.46529981
61Cerebral aneurysm (HP:0004944)2.46355546
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46339058
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.46291395
64Distal lower limb amyotrophy (HP:0008944)2.43277197
65Centrally nucleated skeletal muscle fibers (HP:0003687)2.42063507
66Abnormal ossification of hand bones (HP:0005921)2.41333390
67Myoglobinuria (HP:0002913)2.40767917
68Abnormality of methionine metabolism (HP:0010901)2.40436952
69Hypercholesterolemia (HP:0003124)2.39470537
70Hyperbilirubinemia (HP:0002904)2.37421273
71Diaphragmatic weakness (HP:0009113)2.37000924
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36404644
73Abnormality of polysaccharide metabolism (HP:0011012)2.36404644
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36404644
75Fat malabsorption (HP:0002630)2.36178610
76Elbow flexion contracture (HP:0002987)2.35374583
77Cervical subluxation (HP:0003308)2.34469961
78Aortic aneurysm (HP:0004942)2.34233502
79Mildly elevated creatine phosphokinase (HP:0008180)2.33801703
80Fragile skin (HP:0001030)2.33390143
81Ankle contracture (HP:0006466)2.27795842
82Hypoglycemic seizures (HP:0002173)2.27362805
83Abnormality of the acetabulum (HP:0003170)2.26507426
84Aortic dissection (HP:0002647)2.25938490
85Wormian bones (HP:0002645)2.25586465
86Beaking of vertebral bodies (HP:0004568)2.24768740
87Abnormality of purine metabolism (HP:0004352)2.24323011
88Abnormality of nucleobase metabolism (HP:0010932)2.23287147
89Broad face (HP:0000283)2.22395428
90Opisthotonus (HP:0002179)2.22135723
91Abnormality of pyrimidine metabolism (HP:0004353)2.21215418
92Type 1 muscle fiber predominance (HP:0003803)2.20421740
93Thoracic kyphosis (HP:0002942)2.19810001
94Coxa vara (HP:0002812)2.19062714
95Dilatation of the ascending aorta (HP:0005111)2.18983665
96Scapular winging (HP:0003691)2.16388304
97Disproportionate tall stature (HP:0001519)2.15506290
98Asymmetry of the thorax (HP:0001555)2.12973774
99Multiple enchondromatosis (HP:0005701)2.11463552
100Metabolic acidosis (HP:0001942)2.11369523
101Abnormal cartilage morphology (HP:0002763)2.10224335
102Nonimmune hydrops fetalis (HP:0001790)2.09796978
103Rhabdomyolysis (HP:0003201)2.09625669
104Osteolytic defects of the hand bones (HP:0009699)2.09353457
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.09353457
106Limb-girdle muscle atrophy (HP:0003797)2.08707113
107Atrophic scars (HP:0001075)2.08465182
108Epidermoid cyst (HP:0200040)2.07432991
109Blue sclerae (HP:0000592)2.04910679
110Glomerulonephritis (HP:0000099)2.04810349
111Aneurysm (HP:0002617)2.03612962
112Spontaneous hematomas (HP:0007420)2.03578373
113Ulnar bowing (HP:0003031)2.02303490
114Increased serum ferritin (HP:0003281)2.01988619
115Asymmetric septal hypertrophy (HP:0001670)2.00314945
116Steatorrhea (HP:0002570)1.98409436
117Thin bony cortex (HP:0002753)1.97954671
118Generalized amyotrophy (HP:0003700)1.97813196
119Bladder diverticulum (HP:0000015)1.97091655
120Vascular calcification (HP:0004934)1.96935087
121Nausea (HP:0002018)1.96910255
122Pancreatitis (HP:0001733)1.95663559
123Hypertriglyceridemia (HP:0002155)1.94626709
124Mitral regurgitation (HP:0001653)1.92101570
125Hepatic necrosis (HP:0002605)1.91552331
126Delayed CNS myelination (HP:0002188)1.91454046
127Abnormality of the phalanges of the hallux (HP:0010057)1.91215881
128Lethargy (HP:0001254)1.90898688
129Hemorrhage of the eye (HP:0011885)1.90437721
130Mitral stenosis (HP:0001718)1.89579783
131Hepatocellular carcinoma (HP:0001402)1.89225014
132Aplasia of the musculature (HP:0100854)1.89089949
133Knee flexion contracture (HP:0006380)1.88896859
134Genu recurvatum (HP:0002816)1.88443591
135Chronic otitis media (HP:0000389)1.88371321
136Spondylolisthesis (HP:0003302)1.87435593
137Shallow orbits (HP:0000586)1.87416296
138Abnormal hand bone ossification (HP:0010660)1.86633713
139Protrusio acetabuli (HP:0003179)1.85651306
140Polycythemia (HP:0001901)1.85233875
141Abnormality of iron homeostasis (HP:0011031)1.84933040
142Cardiovascular calcification (HP:0011915)1.83258942
143Gout (HP:0001997)1.83130544
144Hip contracture (HP:0003273)1.82848483
145Abnormality of transition element cation homeostasis (HP:0011030)1.82458287
146Hyperinsulinemic hypoglycemia (HP:0000825)1.82274512
147Vomiting (HP:0002013)1.81218989
148Epistaxis (HP:0000421)1.81136280
149Mesangial abnormality (HP:0001966)1.79250051
150Conjugated hyperbilirubinemia (HP:0002908)1.79212652
151Difficulty running (HP:0009046)1.79027034
152Short nail (HP:0001799)1.77507622
153Recurrent gram-negative bacterial infections (HP:0005420)1.77425635
154Biconcave vertebral bodies (HP:0004586)1.77339219
155Hyperparathyroidism (HP:0000843)1.76892106
156Proximal tubulopathy (HP:0000114)1.75319453
157Back pain (HP:0003418)1.75237421
158Skin nodule (HP:0200036)1.75206234
159Impaired platelet aggregation (HP:0003540)1.74599070
160Abnormal platelet function (HP:0011869)1.74599070
161Mitral valve prolapse (HP:0001634)1.74523158
162Thrombocytosis (HP:0001894)1.73930467
163Abnormality of serum amino acid levels (HP:0003112)1.72950266
164Cardiomegaly (HP:0001640)1.72156927
165Exercise-induced myalgia (HP:0003738)1.71899191
166Abnormality of the lumbar spine (HP:0100712)1.71087301
167Cerebral palsy (HP:0100021)1.70918961
168Peritonitis (HP:0002586)1.70778138
169Urticaria (HP:0001025)1.69927195
170J-shaped sella turcica (HP:0002680)1.69555800
171Abnormality of the nasal mucosa (HP:0000433)1.69508956
172Insomnia (HP:0100785)1.68896812
173Spastic diplegia (HP:0001264)1.67764874
174Slender build (HP:0001533)1.67471617
175Abnormal vertebral ossification (HP:0100569)1.67412894
176Abnormality of the thoracic spine (HP:0100711)1.67400944
177Abnormality of oral frenula (HP:0000190)1.64951087
178Rough bone trabeculation (HP:0100670)1.64877311
179Metatarsus adductus (HP:0001840)1.64615463
180Foot dorsiflexor weakness (HP:0009027)1.63539930
181Abnormality of glycolipid metabolism (HP:0010969)1.62604471
182Abnormality of liposaccharide metabolism (HP:0010968)1.62604471
183Abnormality of glycosphingolipid metabolism (HP:0004343)1.62604471
184Advanced eruption of teeth (HP:0006288)1.61440746
185Syringomyelia (HP:0003396)1.60301158
186Spinal cord lesions (HP:0100561)1.60301158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.68496205
2TRIB33.60273274
3ERN13.40697086
4PKN23.35696342
5PRPF4B3.11945084
6SMG13.03643268
7FLT32.85272142
8ICK2.59493360
9MAP4K12.40151387
10NME22.38285091
11PIK3CG2.25553842
12PDGFRA2.22075234
13CDK122.17561571
14MAP2K32.17194299
15IRAK32.12780622
16SIK11.93171911
17KDR1.82418515
18TTN1.81276098
19TYK21.71493161
20TAOK31.69982010
21FGFR41.66903748
22TGFBR21.66514840
23LRRK21.64197531
24EPHA21.60349384
25ZAP701.53698457
26TESK21.51570359
27KSR21.51039492
28TBK11.49562258
29PTK61.48407696
30NEK91.46120661
31STK101.44010907
32KIT1.41084210
33EEF2K1.38833967
34TESK11.35506311
35MAP3K131.35428277
36MAP3K31.32939426
37BTK1.26754013
38DDR21.25151044
39EPHB11.23714755
40PIM21.23165830
41CSF1R1.22220658
42MAP3K101.19658139
43PTK21.17686789
44MAPKAPK31.17438556
45JAK31.16963555
46MTOR1.16289412
47MST1R1.10762633
48STK161.10213548
49RPS6KA41.06389741
50BLK1.06155807
51ARAF1.05579484
52MAP3K11.05040444
53LATS21.04747146
54CDC42BPA1.02146134
55MAP3K111.00969485
56PRKD21.00331905
57EIF2AK30.96816702
58MAP3K140.95972396
59NLK0.95728471
60SCYL20.90655778
61IRAK40.90097810
62MOS0.88988840
63MYLK0.88866172
64SIK30.88730197
65STK380.88533996
66JAK20.87316809
67TAOK20.85751066
68TAOK10.84668180
69PAK40.82992489
70FGFR30.82665639
71PASK0.82532125
72MAPK110.82296934
73DYRK1B0.81534062
74MAP3K80.81456121
75PDK30.80260193
76PDK40.80260193
77ITK0.80077793
78PDPK10.79776246
79TEC0.79481761
80IKBKE0.77062142
81NTRK10.76559180
82GRK60.74267406
83ILK0.74032433
84INSRR0.72489665
85JAK10.71306707
86PAK20.70919241
87LMTK20.67165893
88MAPK120.67057480
89MAP3K60.66807485
90RIPK10.66748685
91RET0.66335949
92CSK0.65000720
93MAP2K20.64577546
94RIPK40.64262426
95MET0.63445908
96MAP3K20.62416062
97MARK20.61563843
98TRPM70.61419402
99EIF2AK10.59885668
100EPHA30.59646742
101STK40.59579128
102RPS6KA20.58527819
103IRAK10.58084230
104CDK70.56659973
105IKBKB0.56451946
106LYN0.55711932
107PRKD30.55373693
108PDGFRB0.55328242
109LCK0.54733115
110IRAK20.54512789
111MAPK150.52097239
112CDK80.51931682
113MELK0.51490529
114MAP2K60.49780989
115MAP3K70.49507331
116MAPK40.49217855
117TLK10.49109844
118SYK0.47064949
119MAP2K10.46291448
120ABL20.45548181
121BMX0.45333765
122PRKD10.43932524
123PRKG20.43864232
124DMPK0.43815615
125LIMK10.43785795
126HCK0.43607727
127PIM10.43196225
128RPS6KB20.42920334
129CDK60.42699762
130PDK20.42666134
131RPS6KC10.41901486
132RPS6KL10.41901486
133TXK0.41619929
134CLK10.41369239
135ACVR1B0.40163716
136BRSK20.39637302
137WNK40.39463645
138AKT20.38594652
139CDK90.38574255
140HIPK20.38300920
141BUB10.38284995
142CDK40.37409191
143MAPKAPK20.36000465
144PDK10.35763814
145RAF10.34734655
146PRKAA20.34139850
147ROCK20.34099663
148MAP3K50.32087092
149TGFBR10.30515081

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000712.95438010
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.77955653
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67303678
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52645093
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34597883
6Propanoate metabolism_Homo sapiens_hsa006402.29253868
7Tryptophan metabolism_Homo sapiens_hsa003802.29144647
8Nitrogen metabolism_Homo sapiens_hsa009102.19916018
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17870477
10Chronic myeloid leukemia_Homo sapiens_hsa052202.15226470
11Fatty acid metabolism_Homo sapiens_hsa012122.08931728
12Selenocompound metabolism_Homo sapiens_hsa004502.01867133
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96340011
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93184692
15Folate biosynthesis_Homo sapiens_hsa007901.90947950
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90846659
17Peroxisome_Homo sapiens_hsa041461.88691951
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81046344
19Bladder cancer_Homo sapiens_hsa052191.76214042
20Complement and coagulation cascades_Homo sapiens_hsa046101.75621150
21Non-small cell lung cancer_Homo sapiens_hsa052231.73979326
22Pancreatic cancer_Homo sapiens_hsa052121.71848024
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.69054060
24PPAR signaling pathway_Homo sapiens_hsa033201.68716972
25Carbon metabolism_Homo sapiens_hsa012001.66275642
26Sulfur relay system_Homo sapiens_hsa041221.64237510
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63223083
28Fatty acid elongation_Homo sapiens_hsa000621.61067682
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59503875
30Prion diseases_Homo sapiens_hsa050201.58825378
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.56795930
32Focal adhesion_Homo sapiens_hsa045101.56788451
33Staphylococcus aureus infection_Homo sapiens_hsa051501.54564381
34Pyruvate metabolism_Homo sapiens_hsa006201.50408784
35Caffeine metabolism_Homo sapiens_hsa002321.50272886
36beta-Alanine metabolism_Homo sapiens_hsa004101.48999110
37Pentose phosphate pathway_Homo sapiens_hsa000301.48883653
38Thyroid cancer_Homo sapiens_hsa052161.48130079
39Arginine biosynthesis_Homo sapiens_hsa002201.47050491
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45266764
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.44690035
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43886471
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43651051
44Other glycan degradation_Homo sapiens_hsa005111.41275211
45Butanoate metabolism_Homo sapiens_hsa006501.40645261
46Biosynthesis of amino acids_Homo sapiens_hsa012301.35028961
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34319756
48Notch signaling pathway_Homo sapiens_hsa043301.34082763
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.31597618
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31089328
51Fat digestion and absorption_Homo sapiens_hsa049751.30783970
52Chemical carcinogenesis_Homo sapiens_hsa052041.29285394
53Small cell lung cancer_Homo sapiens_hsa052221.27556080
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27352784
55Proteoglycans in cancer_Homo sapiens_hsa052051.27252949
56ECM-receptor interaction_Homo sapiens_hsa045121.26977456
57Endometrial cancer_Homo sapiens_hsa052131.25824237
58Histidine metabolism_Homo sapiens_hsa003401.25455017
59Renal cell carcinoma_Homo sapiens_hsa052111.25434104
60Insulin signaling pathway_Homo sapiens_hsa049101.23716160
61VEGF signaling pathway_Homo sapiens_hsa043701.19850909
62Starch and sucrose metabolism_Homo sapiens_hsa005001.19490643
63Retinol metabolism_Homo sapiens_hsa008301.19296672
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.18905129
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15492795
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.15104793
67One carbon pool by folate_Homo sapiens_hsa006701.14539756
68Amoebiasis_Homo sapiens_hsa051461.14094625
69Glioma_Homo sapiens_hsa052141.13892304
70mTOR signaling pathway_Homo sapiens_hsa041501.12183420
71Protein export_Homo sapiens_hsa030601.11667989
72B cell receptor signaling pathway_Homo sapiens_hsa046621.07257901
73Vitamin digestion and absorption_Homo sapiens_hsa049771.04800697
74Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04233454
75Hepatitis B_Homo sapiens_hsa051611.04100065
76Tyrosine metabolism_Homo sapiens_hsa003501.03294143
77Adherens junction_Homo sapiens_hsa045201.02508890
78ABC transporters_Homo sapiens_hsa020101.01799561
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98924957
80Prostate cancer_Homo sapiens_hsa052150.98784840
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.98559268
82Glutathione metabolism_Homo sapiens_hsa004800.98452399
83Shigellosis_Homo sapiens_hsa051310.98211538
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97989914
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.97869979
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97326810
87Osteoclast differentiation_Homo sapiens_hsa043800.96164074
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.93873302
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93024996
90Lysosome_Homo sapiens_hsa041420.92821915
91Hepatitis C_Homo sapiens_hsa051600.92214985
92AMPK signaling pathway_Homo sapiens_hsa041520.92164429
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91891051
94Sulfur metabolism_Homo sapiens_hsa009200.91504580
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91200226
96Dilated cardiomyopathy_Homo sapiens_hsa054140.89764456
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88477897
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88184187
99MicroRNAs in cancer_Homo sapiens_hsa052060.86811190
100Arginine and proline metabolism_Homo sapiens_hsa003300.86623613
101ErbB signaling pathway_Homo sapiens_hsa040120.85703622
102Phenylalanine metabolism_Homo sapiens_hsa003600.85626292
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85518354
104Ribosome_Homo sapiens_hsa030100.85076800
105Vibrio cholerae infection_Homo sapiens_hsa051100.84316251
106Glycerolipid metabolism_Homo sapiens_hsa005610.83420087
107TNF signaling pathway_Homo sapiens_hsa046680.83095498
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79849671
109Prolactin signaling pathway_Homo sapiens_hsa049170.79805897
110Inositol phosphate metabolism_Homo sapiens_hsa005620.78632505
111Endocytosis_Homo sapiens_hsa041440.78250487
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75770136
113Bile secretion_Homo sapiens_hsa049760.75194515
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74515278
115N-Glycan biosynthesis_Homo sapiens_hsa005100.74421799
116Influenza A_Homo sapiens_hsa051640.74285440
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73364665
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72771518
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.72738712
120Lysine degradation_Homo sapiens_hsa003100.71132185
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70697160
122Steroid biosynthesis_Homo sapiens_hsa001000.70082332
123GnRH signaling pathway_Homo sapiens_hsa049120.69961011
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69934064
125DNA replication_Homo sapiens_hsa030300.68572419
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68190417
127Galactose metabolism_Homo sapiens_hsa000520.68134721
128Estrogen signaling pathway_Homo sapiens_hsa049150.68081838
129HTLV-I infection_Homo sapiens_hsa051660.67798035
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.67579347
131Colorectal cancer_Homo sapiens_hsa052100.62749869
132Salmonella infection_Homo sapiens_hsa051320.61725523
133HIF-1 signaling pathway_Homo sapiens_hsa040660.60332176
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60208363
135Metabolic pathways_Homo sapiens_hsa011000.57139627
136Pyrimidine metabolism_Homo sapiens_hsa002400.56244312
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56023082
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55277045
139Choline metabolism in cancer_Homo sapiens_hsa052310.55090783
140Glucagon signaling pathway_Homo sapiens_hsa049220.54576969
141Base excision repair_Homo sapiens_hsa034100.54374086
142FoxO signaling pathway_Homo sapiens_hsa040680.53461726
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52663612
144Viral myocarditis_Homo sapiens_hsa054160.51092332
145Viral carcinogenesis_Homo sapiens_hsa052030.50972741
146Fructose and mannose metabolism_Homo sapiens_hsa000510.50349589
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47772567
148Fatty acid biosynthesis_Homo sapiens_hsa000610.47229919
149Antigen processing and presentation_Homo sapiens_hsa046120.45651289
150Insulin resistance_Homo sapiens_hsa049310.42271375
151Renin-angiotensin system_Homo sapiens_hsa046140.40525029
152Leishmaniasis_Homo sapiens_hsa051400.38317280
153Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37382187
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36089954
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34830603
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.32903073
157Legionellosis_Homo sapiens_hsa051340.31362761
158Proteasome_Homo sapiens_hsa030500.29741516
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26727107
160alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23261889
161Apoptosis_Homo sapiens_hsa042100.22453709
162Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20682651
163Toxoplasmosis_Homo sapiens_hsa051450.18643483
164Acute myeloid leukemia_Homo sapiens_hsa052210.18341262
165Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18301151
166Pertussis_Homo sapiens_hsa051330.17820541
167Measles_Homo sapiens_hsa051620.16855233
168Intestinal immune network for IgA production_Homo sapiens_hsa046720.15521945
169Primary immunodeficiency_Homo sapiens_hsa053400.15231898
170Malaria_Homo sapiens_hsa051440.13295853

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