TEX264

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.06806446
2L-phenylalanine catabolic process (GO:0006559)6.06806446
3L-phenylalanine metabolic process (GO:0006558)5.98138738
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.98138738
5aromatic amino acid family catabolic process (GO:0009074)5.06485199
6sulfur amino acid catabolic process (GO:0000098)4.87826190
7alpha-linolenic acid metabolic process (GO:0036109)4.77728451
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.65312988
9cysteine metabolic process (GO:0006534)4.58987717
10glyoxylate metabolic process (GO:0046487)4.58588339
11bile acid biosynthetic process (GO:0006699)4.57553139
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.40570009
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.35759423
14kynurenine metabolic process (GO:0070189)4.31729066
15indole-containing compound catabolic process (GO:0042436)4.26353054
16indolalkylamine catabolic process (GO:0046218)4.26353054
17tryptophan catabolic process (GO:0006569)4.26353054
18lysine catabolic process (GO:0006554)4.24485564
19lysine metabolic process (GO:0006553)4.24485564
20GDP-mannose metabolic process (GO:0019673)4.20192979
21protein carboxylation (GO:0018214)4.19425215
22peptidyl-glutamic acid carboxylation (GO:0017187)4.19425215
23negative regulation of fibrinolysis (GO:0051918)4.13249073
24high-density lipoprotein particle remodeling (GO:0034375)4.08755356
25protein maturation by protein folding (GO:0022417)4.05492599
26coenzyme catabolic process (GO:0009109)4.02379156
27amino-acid betaine metabolic process (GO:0006577)3.99680150
28tryptophan metabolic process (GO:0006568)3.98013783
29urea metabolic process (GO:0019627)3.89216546
30urea cycle (GO:0000050)3.89216546
31serine family amino acid catabolic process (GO:0009071)3.88623465
32regulation of protein activation cascade (GO:2000257)3.88197808
33aromatic amino acid family metabolic process (GO:0009072)3.84135007
34cellular ketone body metabolic process (GO:0046950)3.82352719
35bile acid metabolic process (GO:0008206)3.79900022
36regulation of fibrinolysis (GO:0051917)3.77670122
37cellular modified amino acid catabolic process (GO:0042219)3.74225798
38regulation of complement activation (GO:0030449)3.71757919
39regulation of cholesterol esterification (GO:0010872)3.70284160
40complement activation, alternative pathway (GO:0006957)3.67255085
41alpha-amino acid catabolic process (GO:1901606)3.62920301
42plasma lipoprotein particle clearance (GO:0034381)3.62877902
43cofactor catabolic process (GO:0051187)3.61769640
44reverse cholesterol transport (GO:0043691)3.61717267
45homocysteine metabolic process (GO:0050667)3.61486515
46nitrogen cycle metabolic process (GO:0071941)3.60560232
47tyrosine metabolic process (GO:0006570)3.57615196
48aspartate family amino acid catabolic process (GO:0009068)3.55804499
49cellular amino acid catabolic process (GO:0009063)3.52496670
50aldehyde catabolic process (GO:0046185)3.50877752
51regulation of cholesterol homeostasis (GO:2000188)3.49199900
52short-chain fatty acid metabolic process (GO:0046459)3.49161490
53ethanol oxidation (GO:0006069)3.48277931
54regulation of triglyceride catabolic process (GO:0010896)3.46595605
55acetyl-CoA metabolic process (GO:0006084)3.45358430
56fatty acid beta-oxidation (GO:0006635)3.40395845
57pinocytosis (GO:0006907)3.40075453
58glutamate metabolic process (GO:0006536)3.39352547
59serine family amino acid metabolic process (GO:0009069)3.37675038
60ketone body metabolic process (GO:1902224)3.36901781
61protein-lipid complex remodeling (GO:0034368)3.36148027
62macromolecular complex remodeling (GO:0034367)3.36148027
63plasma lipoprotein particle remodeling (GO:0034369)3.36148027
64fatty acid oxidation (GO:0019395)3.36129495
65negative regulation of cholesterol transport (GO:0032375)3.32406551
66negative regulation of sterol transport (GO:0032372)3.32406551
67lipid oxidation (GO:0034440)3.31633740
68fatty acid catabolic process (GO:0009062)3.30988668
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30842173
70serine family amino acid biosynthetic process (GO:0009070)3.29793171
71organic acid catabolic process (GO:0016054)3.26777038
72carboxylic acid catabolic process (GO:0046395)3.26777038
73antigen processing and presentation of endogenous antigen (GO:0019883)3.26328971
74triglyceride homeostasis (GO:0070328)3.25284848
75acylglycerol homeostasis (GO:0055090)3.25284848
76Golgi transport vesicle coating (GO:0048200)3.24897277
77COPI coating of Golgi vesicle (GO:0048205)3.24897277
78monocarboxylic acid catabolic process (GO:0072329)3.24369913
79phospholipid efflux (GO:0033700)3.23205082
80very long-chain fatty acid metabolic process (GO:0000038)3.22610850
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22263350
82fibrinolysis (GO:0042730)3.20711873
83neutrophil activation involved in immune response (GO:0002283)3.17234844
842-oxoglutarate metabolic process (GO:0006103)3.15922428
85cellular glucuronidation (GO:0052695)3.15677402
86carnitine metabolic process (GO:0009437)3.14223831
87cholesterol efflux (GO:0033344)3.12377977
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11473027
89response to mercury ion (GO:0046689)3.11250964
90regulation of cholesterol biosynthetic process (GO:0045540)3.10455855
91heme transport (GO:0015886)3.09663099
92regulation of cholesterol metabolic process (GO:0090181)3.09588854
93glycine metabolic process (GO:0006544)3.09292166
94drug catabolic process (GO:0042737)3.06593543
95uronic acid metabolic process (GO:0006063)3.06368794
96glucuronate metabolic process (GO:0019585)3.06368794
97benzene-containing compound metabolic process (GO:0042537)3.04443803
98drug transmembrane transport (GO:0006855)3.03383366
99urate metabolic process (GO:0046415)3.01243749
100valine metabolic process (GO:0006573)2.98900871
101positive regulation of triglyceride lipase activity (GO:0061365)2.97603066
102positive regulation of lipoprotein lipase activity (GO:0051006)2.97603066
103endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.97232451
104Arp2/3 complex-mediated actin nucleation (GO:0034314)2.96449912
105arginine metabolic process (GO:0006525)2.96294308
106amino sugar catabolic process (GO:0046348)2.95081463
107proline biosynthetic process (GO:0006561)2.94364801
108branched-chain amino acid catabolic process (GO:0009083)2.93948490
109biotin metabolic process (GO:0006768)2.89914270
110bile acid and bile salt transport (GO:0015721)2.89380602
111thioester metabolic process (GO:0035383)2.89368660
112acyl-CoA metabolic process (GO:0006637)2.89368660
113indolalkylamine metabolic process (GO:0006586)2.88952011
114positive regulation of lipid catabolic process (GO:0050996)2.87516828
115negative regulation of protein activation cascade (GO:2000258)2.87493808
116response to interferon-beta (GO:0035456)2.81561063
117immunoglobulin mediated immune response (GO:0016064)2.74897344
118NIK/NF-kappaB signaling (GO:0038061)2.71761088
119cellular response to interferon-beta (GO:0035458)2.69766641
120autophagic vacuole fusion (GO:0000046)2.68909905
121regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67474913
122mannose metabolic process (GO:0006013)2.61964489
123purine deoxyribonucleotide catabolic process (GO:0009155)2.58986896
124deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56518427
125response to peptidoglycan (GO:0032494)2.55481965
126mature B cell differentiation involved in immune response (GO:0002313)2.54871862
127lipoxygenase pathway (GO:0019372)2.52603698
128negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47443136
129negative regulation of nitric oxide biosynthetic process (GO:0045019)2.46348015
130NADH metabolic process (GO:0006734)2.43698065
131regulation of superoxide anion generation (GO:0032928)2.39314759
132detection of bacterium (GO:0016045)2.38819633
133UV protection (GO:0009650)2.37516158
134regulation of RIG-I signaling pathway (GO:0039535)2.37451713
135regulation of metalloenzyme activity (GO:0048552)2.36494033
136regulation of B cell receptor signaling pathway (GO:0050855)2.35651925
137regulation of interferon-beta biosynthetic process (GO:0045357)2.33547254
138amyloid precursor protein catabolic process (GO:0042987)2.32991910
139glycosphingolipid catabolic process (GO:0046479)2.30563396
140barbed-end actin filament capping (GO:0051016)2.30527679
141heme biosynthetic process (GO:0006783)2.30376973
142negative regulation of glycoprotein metabolic process (GO:1903019)2.30096953
143iron-sulfur cluster assembly (GO:0016226)2.29350093
144metallo-sulfur cluster assembly (GO:0031163)2.29350093
145positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28901519
146organelle membrane fusion (GO:0090174)2.28088812
147actin nucleation (GO:0045010)2.27565426
148detection of other organism (GO:0098543)2.26876456
149negative regulation of innate immune response (GO:0045824)2.26687330
150antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.26347141
151negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.26223033
152lipopolysaccharide-mediated signaling pathway (GO:0031663)2.24741613
153heme metabolic process (GO:0042168)2.23990595
154antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.22171897
155regulation of chemokine biosynthetic process (GO:0045073)2.21638731
156regulation of mitochondrial membrane potential (GO:0051881)2.19801088
157positive regulation of B cell differentiation (GO:0045579)2.19177048
158xenobiotic catabolic process (GO:0042178)2.19104071
159macrophage activation involved in immune response (GO:0002281)2.17132451
160modulation by symbiont of host immune response (GO:0052553)2.16371936
161positive regulation by symbiont of host defense response (GO:0052509)2.16371936
162modulation by symbiont of host defense response (GO:0052031)2.16371936
163modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.16371936
164modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.16371936
165positive regulation by organism of defense response of other organism involved in symbiotic interact2.16371936
166proline metabolic process (GO:0006560)2.14552975
167hyaluronan catabolic process (GO:0030214)2.14085299
168type I interferon signaling pathway (GO:0060337)2.13716912
169cellular response to type I interferon (GO:0071357)2.13716912
170pyrimidine nucleoside salvage (GO:0043097)2.13093018
171pyrimidine-containing compound salvage (GO:0008655)2.13093018
172myeloid cell activation involved in immune response (GO:0002275)2.13092896
173negative regulation of myeloid cell apoptotic process (GO:0033033)2.12694714
174glycolipid catabolic process (GO:0019377)2.12546561
175myeloid dendritic cell differentiation (GO:0043011)2.11732400
176fibril organization (GO:0097435)2.11033599
177response to type I interferon (GO:0034340)2.08853148
178pentose metabolic process (GO:0019321)2.08751618
179response to thyroid hormone (GO:0097066)2.08685998
180positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.08206143
181positive regulation of gamma-delta T cell activation (GO:0046645)2.07385376
182type B pancreatic cell proliferation (GO:0044342)2.07302540
183chaperone mediated protein folding requiring cofactor (GO:0051085)2.06595681
184regulation of defense response to virus by virus (GO:0050690)2.06519635
185negative regulation of cell killing (GO:0031342)2.06004729
186negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.06004729
187myeloid dendritic cell activation (GO:0001773)2.05668525
188positive regulation of monocyte chemotaxis (GO:0090026)2.05659100
189regulation of release of cytochrome c from mitochondria (GO:0090199)2.04525770
190positive regulation of chemokine biosynthetic process (GO:0045080)2.04101165
191cyclooxygenase pathway (GO:0019371)2.03605392
192leukocyte aggregation (GO:0070486)2.02999697
193positive regulation of T cell mediated cytotoxicity (GO:0001916)2.01521309
194glucose catabolic process (GO:0006007)2.00954575
195antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.00946239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.14798633
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.97707614
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.38425610
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.18223442
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.44388599
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.88686603
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.58734290
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.29574406
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.28228180
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74105943
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.60280109
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54179135
13VDR_21846776_ChIP-Seq_THP-1_Human2.43043931
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.40355670
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38921755
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36343660
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.34512729
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00785491
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99815831
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96684910
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95126761
22CLOCK_20551151_ChIP-Seq_293T_Human1.94883854
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82985184
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82650658
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82008299
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79610038
27ZNF263_19887448_ChIP-Seq_K562_Human1.79250893
28* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78244475
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76473629
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74436215
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.72494466
32VDR_24763502_ChIP-Seq_THP-1_Human1.67490910
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65783279
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.62951089
35* MAF_26560356_Chip-Seq_TH1_Human1.59784569
36LXR_22292898_ChIP-Seq_THP-1_Human1.59302694
37SPI1_23547873_ChIP-Seq_NB4_Human1.56111587
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53090186
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52805748
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.50176763
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.48888877
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48593628
43MYC_22102868_ChIP-Seq_BL_Human1.48179176
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46799769
45UTX_26944678_Chip-Seq_JUKART_Human1.44678421
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.44255765
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43910535
48* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41748411
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.41499766
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40877038
51MAF_26560356_Chip-Seq_TH2_Human1.40041877
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39579340
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39334861
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.37998239
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37741691
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37221723
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35767884
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35764047
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33458257
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.30532706
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30460346
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30155472
63TFEB_21752829_ChIP-Seq_HELA_Human1.30144308
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29992672
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27293648
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26648065
67IRF8_27001747_Chip-Seq_BMDM_Mouse1.26621308
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24907755
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23600959
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22866051
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22775076
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.22644667
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22188835
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22062565
75* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21625708
76RACK7_27058665_Chip-Seq_MCF-7_Human1.21182048
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21177072
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19605036
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18185905
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18043778
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.17176462
82SPI1_23127762_ChIP-Seq_K562_Human1.16996400
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16182919
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16129344
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15611415
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14915896
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12999878
88DCP1A_22483619_ChIP-Seq_HELA_Human1.12953267
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11826733
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11743981
91MYB_26560356_Chip-Seq_TH2_Human1.11493455
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09874191
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09598769
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09354431
95RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08453166
96CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07964938
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07944222
98RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06950271
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06575744
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05153314
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04948081
102GABP_19822575_ChIP-Seq_HepG2_Human1.04627774
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.03821573
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02400794
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.02107953
106STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02012177
107MYB_26560356_Chip-Seq_TH1_Human1.01628385
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.01610856
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01600671
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00969376
111BCOR_27268052_Chip-Seq_Bcells_Human0.98571765
112FOXA2_19822575_ChIP-Seq_HepG2_Human0.98169778
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98162765
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97680329
115CTCF_20526341_ChIP-Seq_ESCs_Human0.97269116
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95417611
117SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93238215
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93169913
119BCL6_27268052_Chip-Seq_Bcells_Human0.91837745
120EGR1_19032775_ChIP-ChIP_M12_Human0.91398107
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90342696
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90099587
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89284051
124* ATF3_27146783_Chip-Seq_COLON_Human0.88878479
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88373895
126HNF4A_19822575_ChIP-Seq_HepG2_Human0.87457914
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.87415290
128ELK3_25401928_ChIP-Seq_HUVEC_Human0.86718109
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84265646
130TP63_22573176_ChIP-Seq_HFKS_Human0.83495666
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81971384
132* SMC4_20622854_ChIP-Seq_HELA_Human0.81954498
133GATA1_22025678_ChIP-Seq_K562_Human0.81813946
134ELF1_20517297_ChIP-Seq_JURKAT_Human0.81635398
135CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81448944
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81402973
137HTT_18923047_ChIP-ChIP_STHdh_Human0.80838673
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78702118
139* P68_20966046_ChIP-Seq_HELA_Human0.77955488
140* CTCF_27219007_Chip-Seq_Bcells_Human0.77310870
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76778098
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.76581736
143SA1_27219007_Chip-Seq_Bcells_Human0.76510276
144RARB_24833708_ChIP-Seq_LIVER_Mouse0.74993704
145SOX2_20726797_ChIP-Seq_SW620_Human0.74975981
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.73187659
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72968609
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72968609
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72071619
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69602477
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.69397583
152RARA_24833708_ChIP-Seq_LIVER_Mouse0.69273240
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.69090299
154* GATA4_25053715_ChIP-Seq_YYC3_Human0.68298687
155GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67618137
156MYC_19915707_ChIP-ChIP_AK7_Human0.67391422
157P53_21459846_ChIP-Seq_SAOS-2_Human0.67376815
158P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66760378
159E2F1_20622854_ChIP-Seq_HELA_Human0.66623395
160TAF2_19829295_ChIP-Seq_ESCs_Human0.66289521
161SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.66139077
162FOXH1_21741376_ChIP-Seq_ESCs_Human0.65960611
163* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.65816005
164EOMES_21245162_ChIP-Seq_HESCs_Human0.65628904
165PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65616926
166PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.65554470
167OCT4_20526341_ChIP-Seq_ESCs_Human0.65181627
168JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.64313605
169PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63300926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.35392732
2MP0005360_urolithiasis5.99420279
3MP0005365_abnormal_bile_salt4.78329433
4MP0005085_abnormal_gallbladder_physiolo4.48915570
5MP0008875_abnormal_xenobiotic_pharmacok4.29288137
6MP0003806_abnormal_nucleotide_metabolis4.07824371
7MP0009840_abnormal_foam_cell3.93922013
8MP0003195_calcinosis3.04656724
9MP0010329_abnormal_lipoprotein_level2.93809385
10MP0003436_decreased_susceptibility_to2.91335790
11MP0005332_abnormal_amino_acid2.89035053
12MP0003191_abnormal_cellular_cholesterol2.61243361
13MP0003252_abnormal_bile_duct2.61021339
14MP0005083_abnormal_biliary_tract2.57081528
15MP0003329_amyloid_beta_deposits2.42269362
16MP0009333_abnormal_splenocyte_physiolog2.40518282
17MP0001835_abnormal_antigen_presentation2.40418547
18MP0005464_abnormal_platelet_physiology2.29650253
19MP0004019_abnormal_vitamin_homeostasis2.24580322
20MP0005671_abnormal_response_to2.24425481
21MP0002419_abnormal_innate_immunity2.16330996
22MP0009785_altered_susceptibility_to2.14309424
23MP0005025_abnormal_response_to2.13955209
24MP0003705_abnormal_hypodermis_morpholog2.12936853
25MP0008438_abnormal_cutaneous_collagen2.10534544
26MP0002148_abnormal_hypersensitivity_rea2.08398747
27MP0000604_amyloidosis2.06832403
28MP0005000_abnormal_immune_tolerance2.02327341
29MP0002118_abnormal_lipid_homeostasis1.98233429
30MP0000685_abnormal_immune_system1.97139644
31MP0005058_abnormal_lysosome_morphology1.96843707
32MP0001666_abnormal_nutrient_absorption1.90307432
33MP0003763_abnormal_thymus_physiology1.80350432
34MP0005319_abnormal_enzyme/_coenzyme1.76446111
35MP0003011_delayed_dark_adaptation1.76219787
36MP0000609_abnormal_liver_physiology1.72866884
37MP0003724_increased_susceptibility_to1.72675734
38MP0002723_abnormal_immune_serum1.70195408
39MP0001800_abnormal_humoral_immune1.68671609
40MP0002452_abnormal_antigen_presenting1.68589109
41MP0005275_abnormal_skin_tensile1.66138724
42MP0003186_abnormal_redox_activity1.66038876
43MP0005584_abnormal_enzyme/coenzyme_acti1.63283934
44MP0000858_altered_metastatic_potential1.62916184
45MP0002420_abnormal_adaptive_immunity1.62715441
46MP0001819_abnormal_immune_cell1.61433310
47MP0005451_abnormal_body_composition1.61260251
48MP0003303_peritoneal_inflammation1.60924029
49MP0009643_abnormal_urine_homeostasis1.60728190
50MP0001790_abnormal_immune_system1.59887955
51MP0005387_immune_system_phenotype1.59887955
52MP0000015_abnormal_ear_pigmentation1.57088104
53MP0001845_abnormal_inflammatory_respons1.50887028
54MP0001873_stomach_inflammation1.48433021
55MP0010155_abnormal_intestine_physiology1.47916861
56MP0002132_abnormal_respiratory_system1.43076580
57MP0001853_heart_inflammation1.39222329
58MP0000465_gastrointestinal_hemorrhage1.32362240
59MP0002405_respiratory_system_inflammati1.29685069
60MP0004947_skin_inflammation1.29633089
61MP0001542_abnormal_bone_strength1.24576349
62MP0002138_abnormal_hepatobiliary_system1.23226810
63MP0001756_abnormal_urination1.23085599
64MP0003300_gastrointestinal_ulcer1.22670846
65MP0008004_abnormal_stomach_pH1.19029715
66MP0001764_abnormal_homeostasis1.15163396
67MP0000716_abnormal_immune_system1.15155975
68MP0004858_abnormal_nervous_system1.14618956
69MP0001545_abnormal_hematopoietic_system1.13965629
70MP0005397_hematopoietic_system_phenotyp1.13965629
71MP0003656_abnormal_erythrocyte_physiolo1.13611695
72MP0005670_abnormal_white_adipose1.12370321
73MP0003183_abnormal_peptide_metabolism1.12210266
74MP0002796_impaired_skin_barrier1.12087675
75MP0006036_abnormal_mitochondrial_physio1.11726365
76MP0005636_abnormal_mineral_homeostasis1.11531660
77MP0005310_abnormal_salivary_gland1.08125610
78MP0002398_abnormal_bone_marrow1.06205537
79MP0003828_pulmonary_edema1.05520069
80MP0003866_abnormal_defecation1.05100760
81MP0009278_abnormal_bone_marrow1.04917555
82MP0002429_abnormal_blood_cell1.03075065
83MP0002722_abnormal_immune_system1.02372064
84MP0000689_abnormal_spleen_morphology1.02135751
85MP0002998_abnormal_bone_remodeling0.98867318
86MP0002295_abnormal_pulmonary_circulatio0.98303936
87MP0001661_extended_life_span0.97711286
88MP0004130_abnormal_muscle_cell0.97036778
89MP0004381_abnormal_hair_follicle0.95075929
90MP0002254_reproductive_system_inflammat0.94725504
91MP0004510_myositis0.93785199
92MP0004043_abnormal_pH_regulation0.92168176
93MP0003690_abnormal_glial_cell0.91837415
94MP0001958_emphysema0.91085524
95MP0000598_abnormal_liver_morphology0.90885934
96MP0005075_abnormal_melanosome_morpholog0.90874299
97MP0009764_decreased_sensitivity_to0.89924859
98MP0005330_cardiomyopathy0.85590577
99MP0002876_abnormal_thyroid_physiology0.84218908
100MP0003448_altered_tumor_morphology0.84192956
101MP0005084_abnormal_gallbladder_morpholo0.82329726
102MP0002933_joint_inflammation0.81916532
103MP0004185_abnormal_adipocyte_glucose0.81333007
104MP0003075_altered_response_to0.80676084
105MP0008260_abnormal_autophagy0.80424497
106MP0005408_hypopigmentation0.80372436
107MP0000681_abnormal_thyroid_gland0.80090352
108MP0003279_aneurysm0.79908303
109MP0002877_abnormal_melanocyte_morpholog0.77491887
110MP0009642_abnormal_blood_homeostasis0.77085423
111MP0008469_abnormal_protein_level0.74542703
112MP0005390_skeleton_phenotype0.74250336
113MP0006035_abnormal_mitochondrial_morpho0.74143644
114MP0000249_abnormal_blood_vessel0.73963003
115MP0003868_abnormal_feces_composition0.73911434
116MP0005535_abnormal_body_temperature0.73903415
117MP0002136_abnormal_kidney_physiology0.73574919
118MP0002166_altered_tumor_susceptibility0.73559258
119MP0002837_dystrophic_cardiac_calcinosis0.73049237
120MP0003795_abnormal_bone_structure0.72567133
121MP0005376_homeostasis/metabolism_phenot0.70836143
122MP0005595_abnormal_vascular_smooth0.70653706
123MP0002078_abnormal_glucose_homeostasis0.69473019
124MP0002090_abnormal_vision0.68773079
125MP0005647_abnormal_sex_gland0.67855986
126MP0009763_increased_sensitivity_to0.66139137
127MP0000747_muscle_weakness0.65569550
128MP0003638_abnormal_response/metabolism_0.65140054
129MP0001984_abnormal_olfaction0.64078882
130MP0001765_abnormal_ion_homeostasis0.63735739
131MP0005023_abnormal_wound_healing0.63305582
132MP0000230_abnormal_systemic_arterial0.62781165
133MP0000013_abnormal_adipose_tissue0.62453594
134MP0002971_abnormal_brown_adipose0.62307940
135MP0002168_other_aberrant_phenotype0.62231616
136MP0005164_abnormal_response_to0.62081207
137MP0008874_decreased_physiological_sensi0.60680884
138MP0002060_abnormal_skin_morphology0.60060529
139MP0005334_abnormal_fat_pad0.59379415
140MP0005165_increased_susceptibility_to0.58950487
141MP0009697_abnormal_copulation0.58353011
142MP0006082_CNS_inflammation0.56606754
143MP0001243_abnormal_dermal_layer0.56466208
144MP0010368_abnormal_lymphatic_system0.55974585
145MP0003879_abnormal_hair_cell0.55959640
146MP0005395_other_phenotype0.55387223
147MP0000538_abnormal_urinary_bladder0.55382728
148MP0002269_muscular_atrophy0.54130768
149MP0004883_abnormal_blood_vessel0.53906748
150MP0000920_abnormal_myelination0.53723116
151MP0003172_abnormal_lysosome_physiology0.51091383
152MP0009765_abnormal_xenobiotic_induced0.50204257
153MP0000639_abnormal_adrenal_gland0.49991735
154MP0005166_decreased_susceptibility_to0.49246684
155MP0001533_abnormal_skeleton_physiology0.48633809
156MP0005448_abnormal_energy_balance0.46947246
157MP0005666_abnormal_adipose_tissue0.46714541
158MP0002909_abnormal_adrenal_gland0.44930165
159MP0009384_cardiac_valve_regurgitation0.44211586
160MP0000343_altered_response_to0.43708076

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.60332677
2Xanthomatosis (HP:0000991)5.12987795
3Deep venous thrombosis (HP:0002625)5.09493765
4Intrahepatic cholestasis (HP:0001406)4.61395948
5Abnormality of glycolipid metabolism (HP:0010969)4.36439047
6Abnormality of liposaccharide metabolism (HP:0010968)4.36439047
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.36439047
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.29525574
9Hyperlipoproteinemia (HP:0010980)4.28568543
10Hypobetalipoproteinemia (HP:0003563)4.00855471
11Hyperglycinuria (HP:0003108)3.85675531
12Hyperammonemia (HP:0001987)3.80249505
13Abnormality of glycine metabolism (HP:0010895)3.72537170
14Abnormality of serine family amino acid metabolism (HP:0010894)3.72537170
15Hyperglycinemia (HP:0002154)3.70340187
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67909954
17Complement deficiency (HP:0004431)3.66792140
18Ketosis (HP:0001946)3.64611708
19Elevated erythrocyte sedimentation rate (HP:0003565)3.58103207
20Prolonged partial thromboplastin time (HP:0003645)3.56189380
21Abnormality of fatty-acid metabolism (HP:0004359)3.56026348
22Gout (HP:0001997)3.40856266
23Hypolipoproteinemia (HP:0010981)3.38989723
24Abnormality of macrophages (HP:0004311)3.33790860
25Hypoalphalipoproteinemia (HP:0003233)3.31104906
26Recurrent abscess formation (HP:0002722)3.23921069
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17848250
28Eczematoid dermatitis (HP:0000976)3.10489208
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.04067825
30Recurrent bacterial skin infections (HP:0005406)3.02041139
31Loss of speech (HP:0002371)3.00172329
32Petechiae (HP:0000967)2.98934882
33Ketoacidosis (HP:0001993)2.97980895
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.96623073
35Chronic obstructive pulmonary disease (HP:0006510)2.92144569
36Obstructive lung disease (HP:0006536)2.92144569
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.91788094
38Cholecystitis (HP:0001082)2.89095225
39Abnormal gallbladder physiology (HP:0012438)2.89095225
40Increased cerebral lipofuscin (HP:0011813)2.85818079
41Purpura (HP:0000979)2.79975370
42Hypoglycemic coma (HP:0001325)2.75126677
43Fat malabsorption (HP:0002630)2.73738439
44Abnormality of complement system (HP:0005339)2.67581410
45Stomatitis (HP:0010280)2.64114736
46Dicarboxylic aciduria (HP:0003215)2.63214056
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63214056
48Abnormality of purine metabolism (HP:0004352)2.61011378
49Abnormality of methionine metabolism (HP:0010901)2.60718434
50Neurofibrillary tangles (HP:0002185)2.60474777
51Prolonged neonatal jaundice (HP:0006579)2.60254368
52Upper motor neuron abnormality (HP:0002127)2.59139947
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.58747370
54Epidermoid cyst (HP:0200040)2.56309331
55Abnormality of the common coagulation pathway (HP:0010990)2.55079440
56Lethargy (HP:0001254)2.54460729
57Distal lower limb muscle weakness (HP:0009053)2.49962186
58Systemic lupus erythematosus (HP:0002725)2.47952439
59Axonal loss (HP:0003447)2.47149905
60Abnormality of proline metabolism (HP:0010907)2.44560095
61Hydroxyprolinuria (HP:0003080)2.44560095
62Joint hemorrhage (HP:0005261)2.41850967
63Malnutrition (HP:0004395)2.40860066
64Irritability (HP:0000737)2.40633049
65Abnormality of serum amino acid levels (HP:0003112)2.39875761
66Vascular calcification (HP:0004934)2.36654178
67J-shaped sella turcica (HP:0002680)2.35956149
68Neonatal onset (HP:0003623)2.33158587
69Metabolic acidosis (HP:0001942)2.32737725
70Delayed CNS myelination (HP:0002188)2.32736529
71Cholelithiasis (HP:0001081)2.32589535
72Abnormal gallbladder morphology (HP:0012437)2.32200361
73Premature rupture of membranes (HP:0001788)2.31403844
74Amyloidosis (HP:0011034)2.31331318
75Mediastinal lymphadenopathy (HP:0100721)2.29004584
76Sensorimotor neuropathy (HP:0007141)2.28841103
77Hepatosplenomegaly (HP:0001433)2.28298970
78Myocardial infarction (HP:0001658)2.27722201
79Cardiovascular calcification (HP:0011915)2.27643917
80Abnormality of nucleobase metabolism (HP:0010932)2.27318088
81Pustule (HP:0200039)2.26893335
82Hypercholesterolemia (HP:0003124)2.26513940
83Abnormality of the intrinsic pathway (HP:0010989)2.26048814
84Recurrent skin infections (HP:0001581)2.25557060
85Vomiting (HP:0002013)2.24797077
86Recurrent gram-negative bacterial infections (HP:0005420)2.22788836
87Progressive neurologic deterioration (HP:0002344)2.20426611
88Cerebral inclusion bodies (HP:0100314)2.19869742
89Mitral stenosis (HP:0001718)2.18537781
90Abnormality of the Achilles tendon (HP:0005109)2.18153323
91Steatorrhea (HP:0002570)2.18095153
92Protrusio acetabuli (HP:0003179)2.18082696
93Myositis (HP:0100614)2.17392681
94Hypertriglyceridemia (HP:0002155)2.16878394
95Hypertensive crisis (HP:0100735)2.15617294
96Generalized aminoaciduria (HP:0002909)2.15443665
97Brushfield spots (HP:0001088)2.13459804
98Rhabdomyolysis (HP:0003201)2.12891448
99Hyperbilirubinemia (HP:0002904)2.12402896
100Hypokinesia (HP:0002375)2.11006580
101Increased purine levels (HP:0004368)2.11003751
102Hyperuricemia (HP:0002149)2.11003751
103Type I transferrin isoform profile (HP:0003642)2.09908816
104Cerebral edema (HP:0002181)2.09531379
105Skin nodule (HP:0200036)2.09529920
106Reduced subcutaneous adipose tissue (HP:0003758)2.09297992
107Increased serum ferritin (HP:0003281)2.08925835
108Vacuolated lymphocytes (HP:0001922)2.07678428
109Dysostosis multiplex (HP:0000943)2.05760189
110Alkalosis (HP:0001948)2.03925388
111Conjugated hyperbilirubinemia (HP:0002908)2.02147829
112Abnormal cartilage morphology (HP:0002763)1.99155163
113Beaking of vertebral bodies (HP:0004568)1.94641046
114Spastic paraparesis (HP:0002313)1.94018402
115Vertebral compression fractures (HP:0002953)1.92680565
116Polygenic inheritance (HP:0010982)1.92112481
117Urticaria (HP:0001025)1.91645105
118Rough bone trabeculation (HP:0100670)1.89679983
119Opisthotonus (HP:0002179)1.89171634
120Global brain atrophy (HP:0002283)1.87139867
121Peritonitis (HP:0002586)1.87006394
122Hepatic necrosis (HP:0002605)1.86945644
123Urinary glycosaminoglycan excretion (HP:0003541)1.86530678
124Mucopolysacchariduria (HP:0008155)1.86530678
125Protuberant abdomen (HP:0001538)1.85846462
126Fatigue (HP:0012378)1.85282682
127Abnormality of the gallbladder (HP:0005264)1.85222591
128Proximal tubulopathy (HP:0000114)1.84543776
129Chronic mucocutaneous candidiasis (HP:0002728)1.84179147
130Recurrent cutaneous fungal infections (HP:0011370)1.84179147
131Epistaxis (HP:0000421)1.83729474
132Thoracic kyphosis (HP:0002942)1.83326110
133Recurrent fungal infections (HP:0002841)1.82764803
134Hepatocellular carcinoma (HP:0001402)1.82497202
135Growth hormone excess (HP:0000845)1.80325402
136Interstitial pulmonary disease (HP:0006530)1.79525894
137Neoplasm of head and neck (HP:0012288)1.79478777
138Esophageal neoplasm (HP:0100751)1.79478777
139Glucose intolerance (HP:0000833)1.78780051
140Cerebral hemorrhage (HP:0001342)1.78517673
141Pancreatitis (HP:0001733)1.77862986
142Ileus (HP:0002595)1.77557567
143Late onset (HP:0003584)1.75899302
144Acute hepatic failure (HP:0006554)1.75835827
145Gastrointestinal stroma tumor (HP:0100723)1.75794845
146Epiphyseal stippling (HP:0010655)1.74984111
147Abnormal platelet function (HP:0011869)1.73476670
148Impaired platelet aggregation (HP:0003540)1.73476670
149Ragged-red muscle fibers (HP:0003200)1.73470044
150Gastrointestinal inflammation (HP:0004386)1.72401151
151Hepatocellular necrosis (HP:0001404)1.72382280
152Gingivitis (HP:0000230)1.72195421
153Joint stiffness (HP:0001387)1.70517920
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70510038
155Abnormal protein N-linked glycosylation (HP:0012347)1.70510038
156Abnormal protein glycosylation (HP:0012346)1.70510038
157Abnormal glycosylation (HP:0012345)1.70510038
158Asymmetric septal hypertrophy (HP:0001670)1.70260389
159Abnormality of the nasal mucosa (HP:0000433)1.69898920
160Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69575447
161Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69575447
162Abnormality of polysaccharide metabolism (HP:0011012)1.69575447
163Meningitis (HP:0001287)1.69527862
164Spontaneous abortion (HP:0005268)1.69188714
165Colitis (HP:0002583)1.68676372
166Microretrognathia (HP:0000308)1.63597021
167Pulmonary infiltrates (HP:0002113)1.61050274
168Cervical subluxation (HP:0003308)1.60443721
169Inflammation of the large intestine (HP:0002037)1.59586343
170Erythema (HP:0010783)1.59437011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.39778138
2BCKDK4.31458589
3TRIB33.19276720
4ARAF2.99552280
5SIK12.61931140
6IRAK32.58892123
7VRK22.40881376
8SMG12.34722594
9MAP4K12.27276445
10FGFR42.20511228
11PIM21.93215649
12NTRK11.70595815
13PRPF4B1.68932172
14DAPK21.67123802
15KSR21.62647928
16OXSR11.59094719
17TESK11.57658401
18CAMKK21.54398574
19FES1.47434261
20LIMK11.46700820
21MAP3K111.46694990
22MAPKAPK31.43977225
23TESK21.42415103
24TAOK21.41086392
25NME21.41033550
26PKN21.31799919
27CAMKK11.31230548
28WNK41.31196472
29IRAK41.29969157
30RIPK41.29933963
31GRK51.28913265
32KDR1.27329023
33LATS21.25269856
34PDK31.24393387
35PDK41.24393387
36PINK11.20803958
37MST1R1.17364177
38TBK11.14676650
39LMTK21.14526189
40TNK21.14307077
41MAP2K11.12949620
42PTK2B1.12248700
43MAP3K31.09508581
44LRRK21.07249478
45PDK21.07214894
46PAK41.04255694
47MET1.01718477
48DAPK31.01691932
49SCYL21.01114865
50EPHA21.00753186
51ABL20.99591233
52BTK0.97600229
53DDR20.97291190
54PRKD20.96960406
55MAP3K90.96360811
56STK160.95694589
57CSK0.95134392
58STK390.94754334
59PAK30.94340867
60MAP2K40.93209451
61PAK60.91874748
62TGFBR20.90149012
63IKBKB0.87713772
64EPHA40.87632166
65MOS0.86801294
66EPHB10.85727933
67ILK0.84744306
68ZAP700.84416710
69FER0.84322857
70MAP2K20.82667091
71INSRR0.82123233
72TYK20.81800452
73CDK190.81459297
74IKBKE0.80458483
75TAOK10.79285260
76CAMK2G0.79142518
77EIF2AK10.77907285
78BRAF0.77071774
79ITK0.76785813
80MYLK0.76134748
81PIK3CG0.74173188
82HCK0.74137367
83PDPK10.73969278
84GRK60.73769840
85BLK0.73556432
86PHKG20.73538220
87PHKG10.73538220
88MAPK120.73252055
89PTK20.71230986
90RIPK10.70931455
91TXK0.69819189
92MAPK150.69220693
93EIF2AK30.68269551
94PRKD30.67958114
95CSF1R0.67918411
96JAK30.67536800
97TEC0.67024997
98PAK10.65874843
99PDK10.65204357
100PDGFRA0.63841282
101SYK0.63824155
102PRKCZ0.63561142
103ERBB40.63288560
104RET0.63004259
105CDK80.62640253
106MAP3K10.62631340
107STK38L0.62058997
108MAP2K30.61971717
109LYN0.61025656
110MAP3K120.60946063
111MAP3K130.60578406
112SIK30.57995718
113LCK0.57204648
114PRKG20.56411776
115WNK30.56111065
116HIPK20.55697674
117KIT0.55642887
118MAP3K20.55274273
119EPHA30.54513031
120SGK2230.53198238
121SGK4940.53198238
122ICK0.53154684
123STK380.52095444
124NEK10.51293313
125MAPK110.51130878
126MARK30.50470009
127GRK70.49384152
128DAPK10.48602364
129RAF10.48590185
130PRKCG0.48051254
131CDK90.47816361
132CAMK1D0.46211980
133TAF10.44816577
134PRKCI0.44085671
135JAK20.42695240
136BMX0.42573686
137PRKACG0.42417163
138MAP2K60.42240273
139JAK10.42087483
140MAPK40.42002421
141STK100.41400503
142CAMK2D0.40563551
143MINK10.39171572
144MAPKAPK20.38528085
145TTN0.38166784
146PTK60.38080390
147CAMK2B0.37863923
148MAP3K80.37229889
149NEK90.35546538
150PRKD10.35017020
151CDC42BPA0.33259937

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.72813319
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95640213
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92988372
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70564036
5Nitrogen metabolism_Homo sapiens_hsa009102.66090022
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62365912
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53521815
8Fatty acid degradation_Homo sapiens_hsa000712.51852935
9Arginine biosynthesis_Homo sapiens_hsa002202.50093677
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28210556
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15595468
12Butanoate metabolism_Homo sapiens_hsa006502.13638862
13Tryptophan metabolism_Homo sapiens_hsa003802.13133288
14Peroxisome_Homo sapiens_hsa041462.11259572
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06337157
16Propanoate metabolism_Homo sapiens_hsa006402.06121381
17Complement and coagulation cascades_Homo sapiens_hsa046102.04404933
18Fatty acid metabolism_Homo sapiens_hsa012121.98444055
19PPAR signaling pathway_Homo sapiens_hsa033201.86237146
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83855087
21Primary immunodeficiency_Homo sapiens_hsa053401.80735785
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78283159
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78214936
24Allograft rejection_Homo sapiens_hsa053301.72706277
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71857741
26Pyruvate metabolism_Homo sapiens_hsa006201.71039598
27Histidine metabolism_Homo sapiens_hsa003401.70697380
28Chemical carcinogenesis_Homo sapiens_hsa052041.68558735
29Proteasome_Homo sapiens_hsa030501.66970699
30Fatty acid elongation_Homo sapiens_hsa000621.66919614
31Autoimmune thyroid disease_Homo sapiens_hsa053201.65928956
32beta-Alanine metabolism_Homo sapiens_hsa004101.59680552
33Antigen processing and presentation_Homo sapiens_hsa046121.55568139
34Graft-versus-host disease_Homo sapiens_hsa053321.55388630
35Leishmaniasis_Homo sapiens_hsa051401.54387621
36Sulfur metabolism_Homo sapiens_hsa009201.48893196
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.47027330
38Bile secretion_Homo sapiens_hsa049761.46198403
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44681117
40Carbon metabolism_Homo sapiens_hsa012001.41872790
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41761343
42Folate biosynthesis_Homo sapiens_hsa007901.40139170
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.39204642
44Steroid biosynthesis_Homo sapiens_hsa001001.39110231
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38748849
46Caffeine metabolism_Homo sapiens_hsa002321.38292818
47Asthma_Homo sapiens_hsa053101.37642837
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.36237124
49Phenylalanine metabolism_Homo sapiens_hsa003601.35252109
50Rheumatoid arthritis_Homo sapiens_hsa053231.34195468
51Retinol metabolism_Homo sapiens_hsa008301.32591277
52Biosynthesis of amino acids_Homo sapiens_hsa012301.31984426
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31011665
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28858449
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26885204
56Staphylococcus aureus infection_Homo sapiens_hsa051501.25688006
57Sulfur relay system_Homo sapiens_hsa041221.25020179
58Tyrosine metabolism_Homo sapiens_hsa003501.22544161
59Vitamin B6 metabolism_Homo sapiens_hsa007501.21477191
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19748783
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18769703
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18231448
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.15810982
64Osteoclast differentiation_Homo sapiens_hsa043801.15281239
65Arginine and proline metabolism_Homo sapiens_hsa003301.14720406
66Starch and sucrose metabolism_Homo sapiens_hsa005001.12601282
67Intestinal immune network for IgA production_Homo sapiens_hsa046721.12116003
68Hematopoietic cell lineage_Homo sapiens_hsa046401.09721890
69Pertussis_Homo sapiens_hsa051331.07716661
70Tuberculosis_Homo sapiens_hsa051521.04590943
71Viral myocarditis_Homo sapiens_hsa054161.03960648
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02409362
73N-Glycan biosynthesis_Homo sapiens_hsa005101.01446954
74Pyrimidine metabolism_Homo sapiens_hsa002401.01254485
75Fat digestion and absorption_Homo sapiens_hsa049750.99651313
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97417604
77Base excision repair_Homo sapiens_hsa034100.96366576
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.96146838
79Glutathione metabolism_Homo sapiens_hsa004800.95321819
80Vitamin digestion and absorption_Homo sapiens_hsa049770.94308720
81Glycerolipid metabolism_Homo sapiens_hsa005610.93449573
82Selenocompound metabolism_Homo sapiens_hsa004500.90945328
83Ribosome_Homo sapiens_hsa030100.90536948
84Pentose phosphate pathway_Homo sapiens_hsa000300.89941875
85Salmonella infection_Homo sapiens_hsa051320.88062138
86Shigellosis_Homo sapiens_hsa051310.88048265
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86308753
88Type I diabetes mellitus_Homo sapiens_hsa049400.85777726
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80548142
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79238950
91Fructose and mannose metabolism_Homo sapiens_hsa000510.79093361
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78944901
93ABC transporters_Homo sapiens_hsa020100.78552154
94Malaria_Homo sapiens_hsa051440.78114077
95Measles_Homo sapiens_hsa051620.73195044
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72845683
97Fatty acid biosynthesis_Homo sapiens_hsa000610.72026309
98Lysosome_Homo sapiens_hsa041420.70937685
99Influenza A_Homo sapiens_hsa051640.70130774
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69992047
101Collecting duct acid secretion_Homo sapiens_hsa049660.69120679
102Apoptosis_Homo sapiens_hsa042100.68819730
103Toxoplasmosis_Homo sapiens_hsa051450.66681977
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65126903
105Herpes simplex infection_Homo sapiens_hsa051680.64017678
106Legionellosis_Homo sapiens_hsa051340.63501776
107T cell receptor signaling pathway_Homo sapiens_hsa046600.60023644
108Oxidative phosphorylation_Homo sapiens_hsa001900.58555349
109Metabolic pathways_Homo sapiens_hsa011000.58346675
110DNA replication_Homo sapiens_hsa030300.55476897
111Galactose metabolism_Homo sapiens_hsa000520.54491128
112Sphingolipid metabolism_Homo sapiens_hsa006000.51286253
113B cell receptor signaling pathway_Homo sapiens_hsa046620.49835974
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.49706572
115Acute myeloid leukemia_Homo sapiens_hsa052210.49423890
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.49233905
117Regulation of autophagy_Homo sapiens_hsa041400.48976808
118Huntingtons disease_Homo sapiens_hsa050160.47790992
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47601787
120Prion diseases_Homo sapiens_hsa050200.43209891
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41721398
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.41600241
123Other glycan degradation_Homo sapiens_hsa005110.40659328
124Synaptic vesicle cycle_Homo sapiens_hsa047210.40628355
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40311954
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.36445373
127Parkinsons disease_Homo sapiens_hsa050120.34438711
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.29851930
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29387133
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27535438
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27158691
132Vibrio cholerae infection_Homo sapiens_hsa051100.25641628
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25367083
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21381310
135Alzheimers disease_Homo sapiens_hsa050100.20740035
136Linoleic acid metabolism_Homo sapiens_hsa005910.19811366
137Mineral absorption_Homo sapiens_hsa049780.15340176
138Insulin resistance_Homo sapiens_hsa049310.13508708
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12874184
140Renin-angiotensin system_Homo sapiens_hsa046140.12316784
141Phagosome_Homo sapiens_hsa041450.09068063
142AMPK signaling pathway_Homo sapiens_hsa041520.08573557
143Arachidonic acid metabolism_Homo sapiens_hsa005900.07473759
144Protein digestion and absorption_Homo sapiens_hsa049740.06577077
145Lysine degradation_Homo sapiens_hsa003100.05153518
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.04565139
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.03389070

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