ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	female mating behavior (GO:0060180)	8.97281258
2	negative regulation of T cell receptor signaling pathway (GO:0050860)	7.89745666
3	monocyte chemotaxis (GO:0002548)	7.16411498
4	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	6.72605505
5	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	5.49126080
6	relaxation of smooth muscle (GO:0044557)	5.41652772
7	transmission of nerve impulse (GO:0019226)	5.10977683
8	protein-chromophore linkage (GO:0018298)	5.08317632
9	regulation of T cell receptor signaling pathway (GO:0050856)	5.00106044
10	multicellular organismal reproductive behavior (GO:0033057)	4.55218308
11	intestinal epithelial cell development (GO:0060576)	4.22937594
12	indolalkylamine metabolic process (GO:0006586)	4.21104546
13	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.19685816
14	limb bud formation (GO:0060174)	4.13377197
15	cytidine deamination (GO:0009972)	4.03912395
16	cytidine metabolic process (GO:0046087)	4.03912395
17	cytidine catabolic process (GO:0006216)	4.03912395
18	regulation of chemokine-mediated signaling pathway (GO:0070099)	4.03792693
19	regulation of T cell chemotaxis (GO:0010819)	3.94807446
20	positive regulation of T cell chemotaxis (GO:0010820)	3.94807446
21	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.93970630
22	adaptation of signaling pathway (GO:0023058)	3.91149795
23	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.86696489
24	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.86462449
25	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.84757385
26	negative regulation of smooth muscle contraction (GO:0045986)	3.80260314
27	regulation of chronic inflammatory response (GO:0002676)	3.72654399
28	phasic smooth muscle contraction (GO:0014821)	3.69122505
29	DNA deamination (GO:0045006)	3.68317850
30	cellular biogenic amine catabolic process (GO:0042402)	3.65674997
31	amine catabolic process (GO:0009310)	3.65674997
32	positive regulation of interleukin-2 production (GO:0032743)	3.64715068
33	meiotic chromosome segregation (GO:0045132)	3.64126320
34	amino acid salvage (GO:0043102)	3.44812436
35	L-methionine salvage (GO:0071267)	3.44812436
36	L-methionine biosynthetic process (GO:0071265)	3.44812436
37	S-adenosylmethionine metabolic process (GO:0046500)	3.40476261
38	keratinocyte development (GO:0003334)	3.40161177
39	nephron tubule formation (GO:0072079)	3.32891571
40	tryptophan metabolic process (GO:0006568)	3.29338038
41	neural tube formation (GO:0001841)	3.28743769
42	otic vesicle formation (GO:0030916)	3.28085248
43	dopamine transport (GO:0015872)	3.27980752
44	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.27539612
45	opioid receptor signaling pathway (GO:0038003)	3.23541407
46	cellular response to ATP (GO:0071318)	3.23533106
47	regulation of activation of Janus kinase activity (GO:0010533)	3.23110424
48	histone H3-K4 trimethylation (GO:0080182)	3.20449387
49	inner ear receptor stereocilium organization (GO:0060122)	3.16640319
50	peristalsis (GO:0030432)	3.13976679
51	indole-containing compound metabolic process (GO:0042430)	3.07349001
52	proline biosynthetic process (GO:0006561)	3.03906677
53	negative regulation of myotube differentiation (GO:0010832)	3.03483624
54	long term synaptic depression (GO:0060292)	3.00746392
55	negative regulation of muscle contraction (GO:0045932)	2.94392940
56	single strand break repair (GO:0000012)	2.93940972
57	regulation of neurotransmitter uptake (GO:0051580)	2.92933039
58	cellular response to interleukin-15 (GO:0071350)	2.91849662
59	synaptic transmission, dopaminergic (GO:0001963)	2.87160583
60	NLS-bearing protein import into nucleus (GO:0006607)	2.86390175
61	multi-organism reproductive behavior (GO:0044705)	2.86224907
62	nucleotide transmembrane transport (GO:1901679)	2.84973308
63	indole-containing compound catabolic process (GO:0042436)	2.84810292
64	indolalkylamine catabolic process (GO:0046218)	2.84810292
65	tryptophan catabolic process (GO:0006569)	2.84810292
66	reproductive behavior (GO:0019098)	2.82914627
67	positive regulation of T cell apoptotic process (GO:0070234)	2.82455127
68	regulation of cell migration involved in sprouting angiogenesis (GO:0090049)	2.81353453
69	regulation of microtubule-based movement (GO:0060632)	2.81209905
70	nucleoside diphosphate catabolic process (GO:0009134)	2.76619966
71	startle response (GO:0001964)	2.76548216
72	positive regulation of monocyte chemotaxis (GO:0090026)	2.74681920
73	negative regulation of B cell proliferation (GO:0030889)	2.73887624
74	tyrosine phosphorylation of STAT protein (GO:0007260)	2.71273718
75	eosinophil chemotaxis (GO:0048245)	2.70447841
76	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.70352721
77	embryonic epithelial tube formation (GO:0001838)	2.69967256
78	regulation of interleukin-2 production (GO:0032663)	2.66760711
79	regulation of regulatory T cell differentiation (GO:0045589)	2.66720041
80	positive regulation of NF-kappaB import into nucleus (GO:0042346)	2.65208546
81	glial cell proliferation (GO:0014009)	2.56945674
82	tachykinin receptor signaling pathway (GO:0007217)	2.56126668
83	catecholamine transport (GO:0051937)	2.56093835
84	myoblast migration (GO:0051451)	2.54332253
85	peptidyl-lysine trimethylation (GO:0018023)	2.54328836
86	vocalization behavior (GO:0071625)	2.54076214
87	response to monoamine (GO:0071867)	2.54068830
88	response to catecholamine (GO:0071869)	2.54068830
89	epithelial tube formation (GO:0072175)	2.50180358
90	positive regulation of extracellular matrix organization (GO:1903055)	2.49216812
91	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.49087274
92	positive regulation of interleukin-8 secretion (GO:2000484)	2.49083964
93	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.47800912
94	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.47663222
95	spinal cord development (GO:0021510)	2.47215658
96	regulation of T cell migration (GO:2000404)	2.47066499
97	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.46554797
98	DNA demethylation (GO:0080111)	2.45778141
99	regulation of acrosome reaction (GO:0060046)	2.45242185
100	regulation of female receptivity (GO:0045924)	10.4331418

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.82902452
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.19892070
3	VDR_22108803_ChIP-Seq_LS180_Human	3.17968200
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.02761423
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.53768253
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.52275505
7	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.36837666
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36360068
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36233268
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.35730401
11	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.32973372
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.25436291
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.25436291
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.24077716
15	FUS_26573619_Chip-Seq_HEK293_Human	2.14769706
16	P300_19829295_ChIP-Seq_ESCs_Human	2.08202339
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.95777161
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92717162
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.90129116
20	TP53_16413492_ChIP-PET_HCT116_Human	1.88277675
21	* TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.86272390
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79586776
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.74998367
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.74419542
25	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.73810504
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.69660730
27	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.69063291
28	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.61731038
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.60949985
30	SOX2_19829295_ChIP-Seq_ESCs_Human	1.58770063
31	NANOG_19829295_ChIP-Seq_ESCs_Human	1.58770063
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58197109
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52313912
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51103923
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50630853
36	RXR_22108803_ChIP-Seq_LS180_Human	1.48633676
37	TCF4_23295773_ChIP-Seq_U87_Human	1.45571341
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44634783
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44034036
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.42624808
41	STAT3_23295773_ChIP-Seq_U87_Human	1.38626481
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.37098636
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36557238
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35504189
45	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30146134
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29779744
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29660749
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29063949
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28017237
50	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.24466791
51	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.22679093
52	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22212855
53	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.21969301
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21881739
55	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.21881092
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20571947
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19235706
58	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.19117368
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19033953
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.19033953
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18047301
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17973121
63	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17826099
64	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.14633682
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14339875
66	AR_25329375_ChIP-Seq_VCAP_Human	1.13100090
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12662417
68	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.12443081
69	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12422303
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12083267
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.11973763
72	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.11107863
73	EWS_26573619_Chip-Seq_HEK293_Human	1.08384440
74	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.06564606
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05038588
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03023584
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01977349
78	SMRT_27268052_Chip-Seq_Bcells_Human	1.01044389
79	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99332929
80	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.98486869
81	RUNX_20019798_ChIP-Seq_JUKART_Human	0.98233111
82	CJUN_26792858_Chip-Seq_BT549_Human	0.98206411
83	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97263618
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94919276
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94919276
86	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.94630885
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94520263
88	AHR_22903824_ChIP-Seq_MCF-7_Human	0.93882876
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.92909334
90	RUNX2_22187159_ChIP-Seq_PCA_Human	0.92326702
91	NCOR_22424771_ChIP-Seq_293T_Human	0.91983948
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91596140
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91493947
94	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.90950130
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.90450556
96	GATA3_26560356_Chip-Seq_TH2_Human	0.90295640
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.90200126
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.89768520
99	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.89387368
100	EGR1_19032775_ChIP-ChIP_M12_Human	0.89076910

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	8.42196488
2	MP0009780_abnormal_chondrocyte_physiolo	4.84723994
3	MP0002132_abnormal_respiratory_system	3.91459423
4	MP0002163_abnormal_gland_morphology	3.47049968
5	MP0000372_irregular_coat_pigmentation	3.22252370
6	MP0004381_abnormal_hair_follicle	3.03577116
7	MP0005646_abnormal_pituitary_gland	2.55161527
8	MP0005379_endocrine/exocrine_gland_phen	2.26408359
9	MP0001968_abnormal_touch/_nociception	2.19483213
10	MP0005187_abnormal_penis_morphology	2.17335724
11	MP0003045_fibrosis	2.16494468
12	MP0004885_abnormal_endolymph	2.13797248
13	MP0006276_abnormal_autonomic_nervous	2.10974364
14	MP0003938_abnormal_ear_development	2.08623200
15	MP0005671_abnormal_response_to	2.08233056
16	MP0002638_abnormal_pupillary_reflex	1.87701954
17	MP0005360_urolithiasis	1.85764571
18	MP0000647_abnormal_sebaceous_gland	1.79550761
19	MP0000537_abnormal_urethra_morphology	1.73933907
20	MP0003879_abnormal_hair_cell	1.70503918
21	MP0002909_abnormal_adrenal_gland	1.67699353
22	MP0002736_abnormal_nociception_after	1.56001695
23	MP0002138_abnormal_hepatobiliary_system	1.55005057
24	MP0005410_abnormal_fertilization	1.52719977
25	MP0005670_abnormal_white_adipose	1.46270045
26	MP0002282_abnormal_trachea_morphology	1.42436786
27	MP0002090_abnormal_vision	1.42097210
28	MP0004145_abnormal_muscle_electrophysio	1.39664111
29	MP0008872_abnormal_physiological_respon	1.36462021
30	MP0001485_abnormal_pinna_reflex	1.29834630
31	MP0003567_abnormal_fetal_cardiomyocyte	1.29139714
32	MP0005551_abnormal_eye_electrophysiolog	1.26605532
33	MP0001984_abnormal_olfaction	1.24239226
34	MP0002168_other_aberrant_phenotype	1.23886657
35	MP0004782_abnormal_surfactant_physiolog	1.21008606
36	MP0000230_abnormal_systemic_arterial	1.19466671
37	MP0009333_abnormal_splenocyte_physiolog	1.18375397
38	MP0002653_abnormal_ependyma_morphology	1.17967155
39	MP0001501_abnormal_sleep_pattern	1.17102432
40	MP0008775_abnormal_heart_ventricle	1.15262032
41	MP0009765_abnormal_xenobiotic_induced	1.11589259
42	MP0001486_abnormal_startle_reflex	1.06488689
43	MP0000538_abnormal_urinary_bladder	1.05134863
44	MP0005310_abnormal_salivary_gland	1.03765887
45	MP0005395_other_phenotype	1.03027218
46	MP0008004_abnormal_stomach_pH	1.00867405
47	MP0003718_maternal_effect	0.98543220
48	MP0004742_abnormal_vestibular_system	0.98497650
49	MP0001764_abnormal_homeostasis	0.97043741
50	MP0003122_maternal_imprinting	0.95444132
51	MP0000516_abnormal_urinary_system	0.94583122
52	MP0005367_renal/urinary_system_phenotyp	0.94583122
53	MP0000049_abnormal_middle_ear	0.89669102
54	MP0006035_abnormal_mitochondrial_morpho	0.88500202
55	MP0002938_white_spotting	0.88371259
56	MP0003646_muscle_fatigue	0.86337714
57	MP0008961_abnormal_basal_metabolism	0.84456004
58	MP0009745_abnormal_behavioral_response	0.83814124
59	MP0005075_abnormal_melanosome_morpholog	0.81180660
60	MP0002277_abnormal_respiratory_mucosa	0.80936381
61	MP0001529_abnormal_vocalization	0.79688617
62	MP0002735_abnormal_chemical_nociception	0.78671981
63	MP0009764_decreased_sensitivity_to	0.77011184
64	MP0002148_abnormal_hypersensitivity_rea	0.76316843
65	MP0000613_abnormal_salivary_gland	0.75672807
66	MP0001853_heart_inflammation	0.74728623
67	MP0002405_respiratory_system_inflammati	0.74044827
68	MP0005645_abnormal_hypothalamus_physiol	0.72981291
69	MP0010155_abnormal_intestine_physiology	0.72619473
70	MP0003828_pulmonary_edema	0.72617681
71	MP0003724_increased_susceptibility_to	0.72419077
72	MP0003638_abnormal_response/metabolism_	0.72374229
73	MP0000631_abnormal_neuroendocrine_gland	0.70754129
74	MP0001963_abnormal_hearing_physiology	0.69356959
75	MP0008875_abnormal_xenobiotic_pharmacok	0.68471788
76	MP0000026_abnormal_inner_ear	0.67560011
77	MP0004085_abnormal_heartbeat	0.67253241
78	MP0002233_abnormal_nose_morphology	0.66446361
79	MP0002751_abnormal_autonomic_nervous	0.66068138
80	MP0003755_abnormal_palate_morphology	0.65725252
81	MP0000778_abnormal_nervous_system	0.64229790
82	MP0009785_altered_susceptibility_to	0.62553667
83	MP0001905_abnormal_dopamine_level	0.61331671
84	MP0001346_abnormal_lacrimal_gland	0.60634462
85	MP0000534_abnormal_ureter_morphology	0.60523649
86	MP0003880_abnormal_central_pattern	0.59942451
87	MP0003937_abnormal_limbs/digits/tail_de	0.59431869
88	MP0004130_abnormal_muscle_cell	0.59275439
89	MP0003942_abnormal_urinary_system	0.58337798
90	MP0001502_abnormal_circadian_rhythm	0.58039127
91	MP0002557_abnormal_social/conspecific_i	0.57980368
92	MP0008995_early_reproductive_senescence	0.56422773
93	MP0001800_abnormal_humoral_immune	0.56409637
94	MP0001851_eye_inflammation	0.55756228
95	MP0009278_abnormal_bone_marrow	0.53109966
96	MP0002876_abnormal_thyroid_physiology	0.52765746
97	MP0000685_abnormal_immune_system	0.52452821
98	MP0005253_abnormal_eye_physiology	0.51105647
99	MP0008789_abnormal_olfactory_epithelium	0.49849419
100	MP0000569_abnormal_digit_pigmentation	0.49790414

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Concave nail (HP:0001598)	5.25343223
2	Thyroid-stimulating hormone excess (HP:0002925)	4.93879137
3	Severe visual impairment (HP:0001141)	3.87730340
4	Abnormality of lateral ventricle (HP:0030047)	3.78826909
5	Neonatal respiratory distress (HP:0002643)	3.49644764
6	Keratoconjunctivitis sicca (HP:0001097)	3.44234978
7	True hermaphroditism (HP:0010459)	3.41808570
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.39177166
9	Keratoconjunctivitis (HP:0001096)	3.38417639
10	Type I diabetes mellitus (HP:0100651)	3.36886906
11	Hypoproteinemia (HP:0003075)	3.36087116
12	11 pairs of ribs (HP:0000878)	3.22138051
13	Hemiparesis (HP:0001269)	3.17539383
14	Premature skin wrinkling (HP:0100678)	3.06113225
15	Attenuation of retinal blood vessels (HP:0007843)	3.00679344
16	Congenital stationary night blindness (HP:0007642)	2.93274069
17	Tubular atrophy (HP:0000092)	2.92402009
18	Abnormality of midbrain morphology (HP:0002418)	2.77420806
19	Molar tooth sign on MRI (HP:0002419)	2.77420806
20	Stomatitis (HP:0010280)	2.76531423
21	Keratitis (HP:0000491)	2.68758283
22	Anhidrosis (HP:0000970)	2.67069219
23	Abolished electroretinogram (ERG) (HP:0000550)	2.66285976
24	Mesangial abnormality (HP:0001966)	2.65955199
25	Intestinal atresia (HP:0011100)	2.62393321
26	Pancreatic cysts (HP:0001737)	2.60890451
27	Conical tooth (HP:0000698)	2.59896005
28	Hypoplastic iliac wings (HP:0002866)	2.59112880
29	Gaze-evoked nystagmus (HP:0000640)	2.57980912
30	Short chin (HP:0000331)	2.57175310
31	Febrile seizures (HP:0002373)	2.57010925
32	Hyperventilation (HP:0002883)	2.55721314
33	Absent eyebrow (HP:0002223)	2.54813481
34	Abnormal albumin level (HP:0012116)	2.53159848
35	Hypoalbuminemia (HP:0003073)	2.53159848
36	Oligodontia (HP:0000677)	2.52861390
37	Retinal dysplasia (HP:0007973)	2.52375445
38	Broad alveolar ridges (HP:0000187)	2.51022714
39	Focal seizures (HP:0007359)	2.48233426
40	Abnormality of the dental root (HP:0006486)	2.48076782
41	Taurodontia (HP:0000679)	2.48076782
42	Abnormality of permanent molar morphology (HP:0011071)	2.48076782
43	Cerebellar dysplasia (HP:0007033)	2.45328454
44	Hypothermia (HP:0002045)	2.45327745
45	Bony spicule pigmentary retinopathy (HP:0007737)	2.42946836
46	Pigmentary retinal degeneration (HP:0001146)	2.42530600
47	T lymphocytopenia (HP:0005403)	2.36177735
48	Sparse eyelashes (HP:0000653)	2.35781491
49	Abnormality of molar morphology (HP:0011070)	2.34546540
50	Abnormality of molar (HP:0011077)	2.34546540
51	Abnormality of the dental pulp (HP:0006479)	2.34250601
52	Agitation (HP:0000713)	2.33554940
53	Abnormality of the anterior horn cell (HP:0006802)	2.26296369
54	Degeneration of anterior horn cells (HP:0002398)	2.26296369
55	Hypoplastic nipples (HP:0002557)	2.25353428
56	Thyroiditis (HP:0100646)	2.21063456
57	Elevated erythrocyte sedimentation rate (HP:0003565)	2.20147958
58	Respiratory difficulties (HP:0002880)	2.20071821
59	Abnormality of macular pigmentation (HP:0008002)	2.19802571
60	X-linked dominant inheritance (HP:0001423)	2.19459671
61	Albinism (HP:0001022)	2.16311909
62	Narrow forehead (HP:0000341)	2.16262816
63	Bifid tongue (HP:0010297)	2.14782705
64	Brittle hair (HP:0002299)	2.14492904
65	Abnormality of T cell number (HP:0011839)	2.13887095
66	Depressed nasal tip (HP:0000437)	2.12547525
67	Abnormality of the labia minora (HP:0012880)	2.11653758
68	Large for gestational age (HP:0001520)	2.09519475
69	Medial flaring of the eyebrow (HP:0010747)	2.08373472
70	Choroideremia (HP:0001139)	2.07924445
71	Increased connective tissue (HP:0009025)	2.05798311
72	3-Methylglutaconic aciduria (HP:0003535)	2.02545577
73	Diastasis recti (HP:0001540)	2.00816708
74	Optic nerve hypoplasia (HP:0000609)	2.00547894
75	Severe combined immunodeficiency (HP:0004430)	2.00443605
76	Erythroderma (HP:0001019)	1.99360301
77	IgG deficiency (HP:0004315)	1.98907581
78	Gangrene (HP:0100758)	1.98162479
79	Prominent supraorbital ridges (HP:0000336)	1.98073638
80	Cystic liver disease (HP:0006706)	1.91901735
81	Fibular hypoplasia (HP:0003038)	1.89213631
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.89101835
83	Microvesicular hepatic steatosis (HP:0001414)	1.86871435
84	Facial hemangioma (HP:0000329)	1.86014711
85	Pancreatic fibrosis (HP:0100732)	1.85953905
86	Optic neuritis (HP:0100653)	1.85451652
87	Retrobulbar optic neuritis (HP:0100654)	1.85451652
88	Renal hypoplasia (HP:0000089)	1.80017375
89	Type II lissencephaly (HP:0007260)	1.79944473
90	Keratoconus (HP:0000563)	1.78095963
91	Increased corneal curvature (HP:0100692)	1.78095963
92	Ureteral obstruction (HP:0006000)	1.77547125
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74882573
94	Abnormality of transition element cation homeostasis (HP:0011030)	1.74201646
95	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.71227345
96	Hypoplasia of the fovea (HP:0007750)	1.71227345
97	Cupped ear (HP:0000378)	1.68493358
98	Amelogenesis imperfecta (HP:0000705)	1.67517997
99	Abnormal sex determination (HP:0012244)	1.67391250
100	Sex reversal (HP:0012245)	1.67391250

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.47885432
2	CASK	4.10550024
3	FRK	4.02399159
4	ADRBK2	3.45541021
5	MST4	3.31603589
6	MAP4K2	3.21921645
7	EPHB2	2.61253117
8	TAF1	2.44754745
9	WNK3	2.34682494
10	NUAK1	2.33216153
11	TLK1	2.16926466
12	EPHA4	2.08634296
13	STK16	1.84489033
14	ERBB2	1.77155060
15	TYRO3	1.73018768
16	IRAK3	1.70292586
17	BUB1	1.70156282
18	PINK1	1.62602198
19	ACVR1B	1.55344602
20	PIK3CG	1.54396980
21	MAPKAPK3	1.53869844
22	OXSR1	1.44796952
23	IRAK1	1.37696454
24	FES	1.36921853
25	PAK3	1.33556803
26	IKBKB	1.31409671
27	INSRR	1.27522400
28	BCKDK	1.23409191
29	DMPK	1.21797234
30	TNK2	1.20349745
31	PRKCG	1.05556527
32	CHUK	1.04313184
33	KSR1	1.03957339
34	KIT	1.03053591
35	ICK	1.02424219
36	PRKCE	1.02096009
37	PRKCI	1.01493649
38	BMPR2	0.98308037
39	GRK1	0.97934196
40	ILK	0.92958069
41	PLK2	0.92453173
42	IKBKE	0.92359523
43	NTRK2	0.92327084
44	PRKD3	0.90489005
45	PNCK	0.89825109
46	MARK1	0.89531925
47	CDK12	0.88789852
48	MAP3K12	0.83810520
49	STK39	0.83772473
50	PRKCQ	0.83257149
51	ADRBK1	0.82365188
52	TBK1	0.78726539
53	SYK	0.77017080
54	ZAP70	0.75933325
55	CAMK1G	0.74384301
56	DYRK1A	0.68902762
57	ITK	0.61873689
58	ROCK1	0.61346727
59	EPHA2	0.59761259
60	DAPK1	0.58762491
61	VRK1	0.56869366
62	DAPK2	0.56176109
63	KDR	0.55841788
64	MAP3K10	0.55333021
65	DYRK3	0.53559502
66	DYRK2	0.52838425
67	CDK19	0.50416190
68	CSK	0.50047542
69	CAMK1	0.49831483
70	TAOK3	0.48570019
71	TNIK	0.47111506
72	TEC	0.46079878
73	CAMK2A	0.44765207
74	LYN	0.41936173
75	MYLK	0.40991771
76	FGR	0.39882023
77	JAK2	0.38546322
78	LCK	0.37749022
79	MINK1	0.37542306
80	CSNK2A1	0.35596175
81	MAP2K1	0.33829640
82	MAP3K14	0.33742812
83	CDK5	0.32811926
84	MAPK7	0.32571470
85	CSNK1G2	0.31678802
86	PRKCH	0.31074050
87	STK38L	0.30893581
88	TRIM28	0.30450012
89	IRAK4	0.30217602
90	PRKCD	0.29550066
91	ABL1	0.28687753
92	CAMK4	0.28554803
93	MAP3K4	0.28427065
94	LATS2	0.27330233
95	VRK2	0.27155716
96	STK3	0.26172742
97	PRKACA	0.25555875
98	JAK3	0.25532447
99	PRKACG	0.23475928
100	MKNK2	0.22950344

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Tryptophan metabolism_Homo sapiens_hsa00380	3.60439057
2	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.06650001
3	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.81673168
4	Caffeine metabolism_Homo sapiens_hsa00232	2.49356131
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.39445368
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.36010580
7	Olfactory transduction_Homo sapiens_hsa04740	2.20228703
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.18265365
9	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.16445382
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15778659
11	Nitrogen metabolism_Homo sapiens_hsa00910	1.94684597
12	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.93713551
13	Circadian entrainment_Homo sapiens_hsa04713	1.76021815
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.75992808
15	Nicotine addiction_Homo sapiens_hsa05033	1.68184465
16	Phototransduction_Homo sapiens_hsa04744	1.68056216
17	Rheumatoid arthritis_Homo sapiens_hsa05323	1.59836384
18	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.59119845
19	Basal transcription factors_Homo sapiens_hsa03022	1.58234298
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.57650691
21	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.56860059
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.56014888
23	Salivary secretion_Homo sapiens_hsa04970	1.49746929
24	Morphine addiction_Homo sapiens_hsa05032	1.49416418
25	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.48821133
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.43014007
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.40311139
28	Chemokine signaling pathway_Homo sapiens_hsa04062	1.37435338
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36363798
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.33650127
31	Measles_Homo sapiens_hsa05162	1.25366927
32	Arginine and proline metabolism_Homo sapiens_hsa00330	1.25346629
33	Retinol metabolism_Homo sapiens_hsa00830	1.18534013
34	Allograft rejection_Homo sapiens_hsa05330	1.17221416
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.11316570
36	Taste transduction_Homo sapiens_hsa04742	1.11285018
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.10594388
38	ABC transporters_Homo sapiens_hsa02010	1.10526886
39	Circadian rhythm_Homo sapiens_hsa04710	1.10040232
40	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.09788622
41	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.04129063
42	Butanoate metabolism_Homo sapiens_hsa00650	1.02770442
43	cAMP signaling pathway_Homo sapiens_hsa04024	1.01010613
44	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.98424994
45	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.97052707
46	Sulfur metabolism_Homo sapiens_hsa00920	0.95409562
47	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.91348826
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.85782784
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.83863832
50	GABAergic synapse_Homo sapiens_hsa04727	0.83147458
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83084418
52	Calcium signaling pathway_Homo sapiens_hsa04020	0.82879609
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.81298622
54	Purine metabolism_Homo sapiens_hsa00230	0.80821001
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.80260669
56	Antigen processing and presentation_Homo sapiens_hsa04612	0.79013699
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78026516
58	Serotonergic synapse_Homo sapiens_hsa04726	0.77011861
59	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.75621550
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74635256
61	RNA polymerase_Homo sapiens_hsa03020	0.74461628
62	Sulfur relay system_Homo sapiens_hsa04122	0.68950390
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.68908201
64	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67596150
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.66404963
66	Lysine degradation_Homo sapiens_hsa00310	0.63053822
67	Prion diseases_Homo sapiens_hsa05020	0.62788713
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.62306409
69	Platelet activation_Homo sapiens_hsa04611	0.58151138
70	Legionellosis_Homo sapiens_hsa05134	0.55946643
71	Fatty acid degradation_Homo sapiens_hsa00071	0.54222912
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54035591
73	Homologous recombination_Homo sapiens_hsa03440	0.52709142
74	Renin secretion_Homo sapiens_hsa04924	0.51578326
75	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.51246390
76	Regulation of autophagy_Homo sapiens_hsa04140	0.49198649
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47337022
78	TNF signaling pathway_Homo sapiens_hsa04668	0.46808045
79	Proteasome_Homo sapiens_hsa03050	0.46234139
80	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.43938842
81	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42878501
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.42602947
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42506704
84	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.41908327
85	Mineral absorption_Homo sapiens_hsa04978	0.41645082
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40101005
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38792456
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37934151
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37539658
90	Long-term depression_Homo sapiens_hsa04730	0.37114573
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.36110371
92	Alcoholism_Homo sapiens_hsa05034	0.34551176
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34547093
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33983247
95	Cocaine addiction_Homo sapiens_hsa05030	0.33457290
96	Folate biosynthesis_Homo sapiens_hsa00790	0.32495821
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.32244683
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31540421
99	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31195698
100	Parkinsons disease_Homo sapiens_hsa05012	0.30853109

TEX28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »