ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	reproduction (GO:0000003)	9.92406575
2	axonemal dynein complex assembly (GO:0070286)	9.88870295
3	spermatid development (GO:0007286)	9.67339648
4	motile cilium assembly (GO:0044458)	9.57669827
5	cilium or flagellum-dependent cell motility (GO:0001539)	9.41852430
6	cilium movement (GO:0003341)	8.40827670
7	regulation of cilium movement (GO:0003352)	8.03649475
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.67405513
9	single fertilization (GO:0007338)	7.46874085
10	sperm capacitation (GO:0048240)	7.44568422
11	synaptonemal complex organization (GO:0070193)	7.01207850
12	synaptonemal complex assembly (GO:0007130)	6.94919464
13	male meiosis (GO:0007140)	6.92696023
14	negative regulation of inclusion body assembly (GO:0090084)	6.71741161
15	piRNA metabolic process (GO:0034587)	6.57100664
16	spermatogenesis (GO:0007283)	6.47072449
17	male gamete generation (GO:0048232)	6.44651353
18	organic cation transport (GO:0015695)	6.38898569
19	microtubule depolymerization (GO:0007019)	6.38404866
20	fertilization (GO:0009566)	6.24254691
21	spermatid nucleus differentiation (GO:0007289)	6.20797308
22	gamete generation (GO:0007276)	5.93096386
23	regulation of inclusion body assembly (GO:0090083)	5.68578419
24	calcium ion-dependent exocytosis (GO:0017156)	5.63298181
25	germ cell development (GO:0007281)	5.35365340
26	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.32107185
27	sexual reproduction (GO:0019953)	5.21575176
28	ventricular system development (GO:0021591)	5.15167887
29	cell recognition (GO:0008037)	5.09043700
30	glycerol ether metabolic process (GO:0006662)	4.98427713
31	single strand break repair (GO:0000012)	4.80205591
32	chromosome organization involved in meiosis (GO:0070192)	4.71306073
33	microtubule severing (GO:0051013)	4.69656669
34	regulation of microtubule-based movement (GO:0060632)	4.69066341
35	multicellular organismal reproductive process (GO:0048609)	4.66768701
36	chromosome condensation (GO:0030261)	4.61856520
37	ether metabolic process (GO:0018904)	4.60693383
38	DNA packaging (GO:0006323)	4.37983254
39	male meiosis I (GO:0007141)	4.36975705
40	DNA methylation involved in gamete generation (GO:0043046)	4.24794830
41	seminiferous tubule development (GO:0072520)	4.19896703
42	protein K11-linked deubiquitination (GO:0035871)	4.16806681
43	left/right pattern formation (GO:0060972)	4.14436213
44	meiotic nuclear division (GO:0007126)	4.11486726
45	chaperone-mediated protein complex assembly (GO:0051131)	3.86329736
46	multicellular organismal development (GO:0007275)	3.74920772
47	monoubiquitinated protein deubiquitination (GO:0035520)	3.71674705
48	genitalia morphogenesis (GO:0035112)	3.59828939
49	sequestering of actin monomers (GO:0042989)	3.53465919
50	meiosis I (GO:0007127)	3.44433340
51	protein polyglutamylation (GO:0018095)	3.30439214
52	microtubule polymerization or depolymerization (GO:0031109)	3.29256852
53	meiotic cell cycle (GO:0051321)	3.15786835
54	polyol catabolic process (GO:0046174)	3.14965159
55	protein refolding (GO:0042026)	3.11811346
56	glycolytic process (GO:0006096)	3.11543367
57	positive regulation of macrophage activation (GO:0043032)	3.06091851
58	nucleus organization (GO:0006997)	3.05806330
59	alditol metabolic process (GO:0019400)	3.02403199
60	protein localization to cilium (GO:0061512)	2.98694892
61	carnitine transport (GO:0015879)	2.96932403
62	amino-acid betaine transport (GO:0015838)	2.96932403
63	regulation of spindle checkpoint (GO:0090231)	2.96822851
64	nucleoside diphosphate phosphorylation (GO:0006165)	2.93264256
65	cilium organization (GO:0044782)	2.90554355
66	interferon-gamma secretion (GO:0072643)	2.86658508
67	centriole assembly (GO:0098534)	2.82409212
68	cilium assembly (GO:0042384)	2.80742051
69	carnitine transmembrane transport (GO:1902603)	2.80546922
70	microtubule-based movement (GO:0007018)	2.77073773
71	cellular component assembly involved in morphogenesis (GO:0010927)	2.74889356
72	polyamine biosynthetic process (GO:0006596)	2.72686660
73	GTP biosynthetic process (GO:0006183)	2.72249235
74	chromatin silencing (GO:0006342)	2.71908232
75	intraciliary transport (GO:0042073)	2.70113488
76	mitotic sister chromatid cohesion (GO:0007064)	2.67518877
77	synapsis (GO:0007129)	2.65747168
78	cilium morphogenesis (GO:0060271)	2.65419234
79	meiotic cell cycle process (GO:1903046)	2.64667752
80	glycerol metabolic process (GO:0006071)	2.61992081
81	lactate metabolic process (GO:0006089)	2.61581358
82	axoneme assembly (GO:0035082)	2.57849166
83	centriole replication (GO:0007099)	2.50560847
84	negative regulation of organelle assembly (GO:1902116)	2.47291859
85	regulation of cilium assembly (GO:1902017)	2.46627372
86	RNA localization (GO:0006403)	2.42493890
87	nucleosome disassembly (GO:0006337)	2.41513623
88	protein-DNA complex disassembly (GO:0032986)	2.41513623
89	cell wall macromolecule metabolic process (GO:0044036)	15.1832260
90	cell wall macromolecule catabolic process (GO:0016998)	15.1832260
91	sperm motility (GO:0030317)	13.8837443
92	fusion of sperm to egg plasma membrane (GO:0007342)	13.8401751
93	acrosome reaction (GO:0007340)	11.9230900
94	acrosome assembly (GO:0001675)	11.8437938
95	sperm-egg recognition (GO:0035036)	11.7222142
96	multicellular organism reproduction (GO:0032504)	11.2692983
97	binding of sperm to zona pellucida (GO:0007339)	10.6510930
98	plasma membrane fusion (GO:0045026)	10.5484891
99	cell-cell recognition (GO:0009988)	10.5040866
100	epithelial cilium movement (GO:0003351)	10.4146946

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.23893169
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.94847816
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.58587625
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.40823199
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.21836039
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.86812068
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.71884503
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37039998
9	VDR_22108803_ChIP-Seq_LS180_Human	2.32902241
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.32883504
11	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.08822559
12	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.07284379
13	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.05311531
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04628543
15	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.98425699
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92521524
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.78731761
18	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.76081184
19	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.72574719
20	STAT1_17558387_ChIP-Seq_HELA_Human	1.72252412
21	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.71121810
22	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.69868289
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67410594
24	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.67202535
25	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.64634970
26	KDM2B_26808549_Chip-Seq_REH_Human	1.63557039
27	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.59148351
28	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.58857013
29	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56077807
30	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.55445743
31	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.52970375
32	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.52186050
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50782414
34	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.46632528
35	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.44346249
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.43306926
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43306926
38	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.40453121
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40090477
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38215640
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35834046
42	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.33860916
43	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.32545439
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.32244140
45	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30661952
46	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.30093296
47	P53_21459846_ChIP-Seq_SAOS-2_Human	1.27496757
48	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27379707
49	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24468265
50	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.23650843
51	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.22587287
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22303170
53	GF1_26923725_Chip-Seq_HPCs_Mouse	1.20347194
54	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17277064
55	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.16754165
56	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16553570
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16220096
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16220096
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15674374
60	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.15147432
61	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.14193485
62	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13764940
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13733154
64	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.13309981
65	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.08798842
66	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.08084139
67	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.07672223
68	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.07323457
69	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.06970739
70	P300_18555785_Chip-Seq_ESCs_Mouse	1.06753011
71	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06366345
72	TAF15_26573619_Chip-Seq_HEK293_Human	1.06188758
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05845222
74	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.04097037
75	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.03682209
76	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.03237782
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02878935
78	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02706093
79	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02665254
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02423812
81	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.02222702
82	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.99110012
83	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.98555217
84	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.97704103
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97259912
86	ERG_20517297_ChIP-Seq_VCAP_Human	0.97168052
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97002588
88	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.96594638
89	NFYB_21822215_ChIP-Seq_K562_Human	0.95946670
90	SOX9_26525672_Chip-Seq_HEART_Mouse	0.95000663
91	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.93579165
92	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93526767
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.93443387
94	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.93361453
95	PU1_27457419_Chip-Seq_LIVER_Mouse	0.93198566
96	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.93100680
97	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.92149471
98	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.91943204
99	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.91897694
100	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.91589139

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.17819671
2	MP0001929_abnormal_gametogenesis	5.61710793
3	MP0008877_abnormal_DNA_methylation	3.94993394
4	MP0002210_abnormal_sex_determination	3.42566110
5	MP0002161_abnormal_fertility/fecundity	3.35856941
6	MP0001145_abnormal_male_reproductive	2.91743426
7	MP0005670_abnormal_white_adipose	2.67805353
8	MP0000653_abnormal_sex_gland	2.54086923
9	MP0002653_abnormal_ependyma_morphology	2.45932278
10	MP0005410_abnormal_fertilization	16.5639535
11	MP0005623_abnormal_meninges_morphology	1.51354704
12	MP0002160_abnormal_reproductive_system	1.49812343
13	MP0004233_abnormal_muscle_weight	1.44609750
14	MP0002282_abnormal_trachea_morphology	1.24939573
15	MP0001984_abnormal_olfaction	1.22124695
16	MP0003646_muscle_fatigue	1.20816261
17	MP0001765_abnormal_ion_homeostasis	1.18026436
18	MP0008058_abnormal_DNA_repair	1.12372945
19	MP0002234_abnormal_pharynx_morphology	0.94568588
20	MP0005647_abnormal_sex_gland	0.92975408
21	MP0009046_muscle_twitch	0.89412506
22	MP0005389_reproductive_system_phenotype	0.75089062
23	MP0003878_abnormal_ear_physiology	0.67897130
24	MP0005377_hearing/vestibular/ear_phenot	0.67897130
25	MP0003011_delayed_dark_adaptation	0.66611659
26	MP0005636_abnormal_mineral_homeostasis	0.64516833
27	MP0008995_early_reproductive_senescence	0.61890293
28	MP0003115_abnormal_respiratory_system	0.60142409
29	MP0002102_abnormal_ear_morphology	0.58650266
30	MP0002928_abnormal_bile_duct	0.58297072
31	MP0001324_abnormal_eye_pigmentation	0.54951215
32	MP0005666_abnormal_adipose_tissue	0.50242497
33	MP0002736_abnormal_nociception_after	0.49885307
34	MP0004019_abnormal_vitamin_homeostasis	0.49720281
35	MP0010094_abnormal_chromosome_stability	0.49061015
36	MP0005551_abnormal_eye_electrophysiolog	0.48327923
37	MP0000358_abnormal_cell_content/	0.47481054
38	MP0003699_abnormal_female_reproductive	0.45852190
39	MP0004036_abnormal_muscle_relaxation	0.44704319
40	MP0001764_abnormal_homeostasis	0.44059927
41	MP0005253_abnormal_eye_physiology	0.42531310
42	MP0001293_anophthalmia	0.42370625
43	MP0002269_muscular_atrophy	0.41073908
44	MP0000569_abnormal_digit_pigmentation	0.39510165
45	MP0003329_amyloid_beta_deposits	0.37512362
46	MP0006036_abnormal_mitochondrial_physio	0.35494440
47	MP0009115_abnormal_fat_cell	0.35387080
48	MP0002971_abnormal_brown_adipose	0.34713433
49	MP0003950_abnormal_plasma_membrane	0.32359700
50	MP0005391_vision/eye_phenotype	0.32299316
51	MP0001119_abnormal_female_reproductive	0.30993188
52	MP0000534_abnormal_ureter_morphology	0.29753577
53	MP0004133_heterotaxia	0.29733669
54	MP0001968_abnormal_touch/_nociception	0.29699698
55	MP0003633_abnormal_nervous_system	0.29447765
56	MP0008875_abnormal_xenobiotic_pharmacok	0.29030515
57	MP0001545_abnormal_hematopoietic_system	0.27848222
58	MP0005397_hematopoietic_system_phenotyp	0.27848222
59	MP0004811_abnormal_neuron_physiology	0.25395177
60	MP0002796_impaired_skin_barrier	0.25301943
61	MP0002139_abnormal_hepatobiliary_system	0.25168125
62	MP0002132_abnormal_respiratory_system	0.24936234
63	MP0003942_abnormal_urinary_system	0.24718679
64	MP0006035_abnormal_mitochondrial_morpho	0.24545739
65	MP0003111_abnormal_nucleus_morphology	0.23853286
66	MP0003786_premature_aging	0.22321591
67	MP0003879_abnormal_hair_cell	0.22261431
68	MP0001986_abnormal_taste_sensitivity	0.21276966
69	MP0010307_abnormal_tumor_latency	0.21251549
70	MP0003861_abnormal_nervous_system	0.20917938
71	MP0009278_abnormal_bone_marrow	0.20457476
72	MP0002693_abnormal_pancreas_physiology	0.20377100
73	MP0002169_no_abnormal_phenotype	0.19924062
74	MP0002873_normal_phenotype	0.19708114
75	MP0001849_ear_inflammation	0.19619848
76	MP0003631_nervous_system_phenotype	0.19300224
77	MP0002152_abnormal_brain_morphology	0.19262517
78	MP0005365_abnormal_bile_salt	0.18999453
79	MP0000604_amyloidosis	0.17783252
80	MP0004742_abnormal_vestibular_system	0.17660581
81	MP0005319_abnormal_enzyme/_coenzyme	0.17507318
82	MP0002092_abnormal_eye_morphology	0.16825448
83	MP0003959_abnormal_lean_body	0.16748292
84	MP0009672_abnormal_birth_weight	0.16722236
85	MP0006072_abnormal_retinal_apoptosis	0.16520301
86	MP0002295_abnormal_pulmonary_circulatio	0.15942115
87	MP0003948_abnormal_gas_homeostasis	0.15843297
88	MP0002229_neurodegeneration	0.14894744
89	MP0002405_respiratory_system_inflammati	0.14827815
90	MP0004145_abnormal_muscle_electrophysio	0.14766654
91	MP0008569_lethality_at_weaning	0.14348983
92	MP0000313_abnormal_cell_death	0.14236742
93	MP0005195_abnormal_posterior_eye	0.13791569
94	MP0001730_embryonic_growth_arrest	0.13511129
95	MP0000462_abnormal_digestive_system	0.13126496
96	MP0002118_abnormal_lipid_homeostasis	0.12909263
97	MP0009250_abnormal_appendicular_skeleto	0.12586285
98	MP0010329_abnormal_lipoprotein_level	0.12555109
99	MP0000001_mammalian_phenotype	0.12095098
100	MP0008057_abnormal_DNA_replication	0.11099155

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.39942427
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.39046201
3	Abnormal respiratory epithelium morphology (HP:0012253)	9.39046201
4	Rhinitis (HP:0012384)	7.58505986
5	Abnormal ciliary motility (HP:0012262)	7.53747144
6	Chronic bronchitis (HP:0004469)	7.51853152
7	Infertility (HP:0000789)	6.64615834
8	Nasal polyposis (HP:0100582)	6.38981486
9	Abnormality of the nasal mucosa (HP:0000433)	5.24331441
10	Bronchitis (HP:0012387)	4.60858677
11	Bronchiectasis (HP:0002110)	4.46724955
12	Male infertility (HP:0003251)	4.36034031
13	Nephronophthisis (HP:0000090)	4.08178079
14	Recurrent sinusitis (HP:0011108)	3.47446685
15	Abnormal spermatogenesis (HP:0008669)	3.39251409
16	Recurrent otitis media (HP:0000403)	3.29831476
17	Abnormality of the renal medulla (HP:0100957)	3.13080847
18	Tubulointerstitial nephritis (HP:0001970)	2.92957175
19	Medial flaring of the eyebrow (HP:0010747)	2.68103481
20	Recurrent bronchitis (HP:0002837)	2.66862360
21	Molar tooth sign on MRI (HP:0002419)	2.58431965
22	Abnormality of midbrain morphology (HP:0002418)	2.58431965
23	Impulsivity (HP:0100710)	2.44032058
24	Tubular atrophy (HP:0000092)	2.42524116
25	Tubulointerstitial abnormality (HP:0001969)	2.31187304
26	Azoospermia (HP:0000027)	2.21529624
27	Abnormal gallbladder physiology (HP:0012438)	2.17340387
28	Cholecystitis (HP:0001082)	2.17340387
29	Gonadotropin excess (HP:0000837)	2.11753081
30	Absent/shortened dynein arms (HP:0200106)	13.5582437
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.5582437
32	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.2972150
33	Dyschromatopsia (HP:0007641)	1.93700698
34	Decreased central vision (HP:0007663)	1.86024802
35	Postaxial foot polydactyly (HP:0001830)	1.81035591
36	Stage 5 chronic kidney disease (HP:0003774)	1.74441006
37	Spastic tetraparesis (HP:0001285)	1.73626230
38	Tubulointerstitial fibrosis (HP:0005576)	1.71637714
39	Asymmetric septal hypertrophy (HP:0001670)	1.71242004
40	Congenital hepatic fibrosis (HP:0002612)	1.68644717
41	Gait imbalance (HP:0002141)	1.65191633
42	Congenital primary aphakia (HP:0007707)	1.65106434
43	Abnormality of the renal cortex (HP:0011035)	1.63793862
44	Heterotopia (HP:0002282)	1.61860229
45	Abnormality of the dental root (HP:0006486)	1.60878017
46	Taurodontia (HP:0000679)	1.60878017
47	Abnormality of permanent molar morphology (HP:0011071)	1.60878017
48	Abnormality of renal excretion (HP:0011036)	1.58874267
49	Choroideremia (HP:0001139)	1.58289138
50	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.57818188
51	Chronic sinusitis (HP:0011109)	1.57525568
52	Polydipsia (HP:0001959)	1.57287247
53	Abnormal drinking behavior (HP:0030082)	1.57287247
54	Aplasia/Hypoplasia of the lens (HP:0008063)	1.56823476
55	Abnormal biliary tract physiology (HP:0012439)	1.56784039
56	Bile duct proliferation (HP:0001408)	1.56784039
57	Short ribs (HP:0000773)	1.55195351
58	Bundle branch block (HP:0011710)	1.52800857
59	Abnormality of molar (HP:0011077)	1.50981265
60	Abnormality of molar morphology (HP:0011070)	1.50981265
61	Abnormality of the dental pulp (HP:0006479)	1.48294637
62	Fibular hypoplasia (HP:0003038)	1.48148878
63	Postaxial hand polydactyly (HP:0001162)	1.47791691
64	Renal dysplasia (HP:0000110)	1.46881066
65	Oculomotor apraxia (HP:0000657)	1.46703833
66	Bell-shaped thorax (HP:0001591)	1.46433864
67	Hemorrhage of the eye (HP:0011885)	1.44471370
68	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.43222898
69	Double outlet right ventricle (HP:0001719)	1.42081174
70	Congenital malformation of the right heart (HP:0011723)	1.42081174
71	Nephrogenic diabetes insipidus (HP:0009806)	1.41650920
72	Facial cleft (HP:0002006)	1.38674502
73	Cystic liver disease (HP:0006706)	1.37489652
74	Deformed sella turcica (HP:0002681)	1.35313883
75	Abnormality of dentin (HP:0010299)	1.34844922
76	Optic nerve hypoplasia (HP:0000609)	1.34652107
77	Abnormality of saccadic eye movements (HP:0000570)	1.32200120
78	Pancreatic fibrosis (HP:0100732)	1.32135196
79	Constricted visual fields (HP:0001133)	1.31610304
80	Vaginal atresia (HP:0000148)	1.30708659
81	Abnormality of the lower motor neuron (HP:0002366)	1.28829472
82	Genital tract atresia (HP:0001827)	1.28808996
83	Easy fatigability (HP:0003388)	1.27697857
84	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.25856293
85	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.25464734
86	Absent epiphyses (HP:0010577)	1.25464734
87	Sensory axonal neuropathy (HP:0003390)	1.25338702
88	Abnormality of the neuromuscular junction (HP:0003398)	1.24317537
89	Fatigable weakness (HP:0003473)	1.24317537
90	Cerebellar dysplasia (HP:0007033)	1.24288257
91	Abnormality of ocular smooth pursuit (HP:0000617)	1.24186319
92	Neurofibrillary tangles (HP:0002185)	1.23513337
93	Poor coordination (HP:0002370)	1.21817182
94	Vascular calcification (HP:0004934)	1.20821692
95	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.20539780
96	Abnormal urine output (HP:0012590)	1.19781680
97	True hermaphroditism (HP:0010459)	1.19409598
98	Nephropathy (HP:0000112)	1.16958902
99	J-shaped sella turcica (HP:0002680)	1.15699104
100	Absent frontal sinuses (HP:0002688)	1.14684481

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK4	9.11982404
2	PDK3	9.11982404
3	PDK2	5.92140147
4	TESK1	5.37134388
5	PRKD3	4.09711726
6	ICK	3.69415246
7	PTK2B	1.93454540
8	WNK4	1.85171284
9	STK39	1.78560106
10	PNCK	1.64011918
11	STK38	1.57295699
12	DYRK1B	1.34899566
13	NEK2	1.32974573
14	PDK1	1.15117494
15	IRAK1	0.97297056
16	LMTK2	0.75835148
17	DYRK3	0.75097356
18	TYRO3	0.74019889
19	MAP2K6	0.72409925
20	MAPK15	0.70499903
21	WNK1	0.64171801
22	PASK	0.64039273
23	RIPK4	0.63173097
24	PDPK1	0.61000055
25	CCNB1	0.58610799
26	STK3	0.54545661
27	CHEK2	0.54228614
28	EEF2K	0.52658401
29	IRAK2	0.52402034
30	TTK	0.49001671
31	CAMK1G	0.45719581
32	NTRK2	0.43856759
33	STK38L	0.42462374
34	TESK2	0.42233424
35	PINK1	0.40962291
36	PLK4	0.39210740
37	MUSK	0.37696864
38	CHEK1	0.34347817
39	MAPKAPK5	0.31534420
40	PAK1	0.31042645
41	PRKCG	0.29308969
42	ATM	0.23332953
43	PAK2	0.22867412
44	NEK6	0.22489150
45	WEE1	0.21327394
46	MARK2	0.21174393
47	MAP3K10	0.20583131
48	CAMKK1	0.20082978
49	ATR	0.18367582
50	MTOR	0.18317870
51	BRSK2	0.18174309
52	PRKCZ	0.16164115
53	PRKAA1	0.15059911
54	STK11	0.14249303
55	PRKG2	0.14026558
56	PKN1	0.13808076
57	PAK4	0.12910832
58	PRKCQ	0.12696461
59	RPS6KB1	0.10259511
60	CDK15	0.09938546
61	PLK1	0.09589306
62	CDC7	0.09212703
63	MAP3K5	0.07780476
64	CDK18	0.07572974
65	CDK12	0.06876245
66	CDK11A	0.06400139
67	RPS6KA1	0.06040003
68	MARK3	0.05860586
69	PRKG1	0.05708106
70	CSNK2A1	0.05602004
71	YES1	0.05587847
72	PRKACG	0.05396280
73	GSK3B	0.04827033
74	BRSK1	0.03964002
75	CAMK2A	0.03518000
76	CDK14	0.03382553
77	CSNK2A2	0.02785963
78	CDK6	0.02662854
79	CSNK1D	0.02338241
80	RIPK1	0.02051940
81	PRKCD	0.01303701
82	PRKCA	0.01121549
83	MAPK8	0.01118819
84	PDGFRB	0.01116354
85	CDK1	0.00899729
86	STK10	0.00889682
87	PRKACB	0.00750673
88	CDK2	0.00537132
89	PRKCB	0.00496838
90	WNK3	0.00281515
91	PIM1	0.00016003
92	CAMK1	-0.0314523
93	BRAF	-0.0301689
94	GSK3A	-0.0252707
95	RPS6KA3	-0.0242902
96	PRKACA	-0.0240876
97	MAP3K1	-0.0168206
98	CSF1R	-0.0089392
99	EGFR	-0.0069657
100	ZAP70	-0.0042181

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.56349771
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.18420342
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.54378129
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.51901768
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.00154940
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.94807066
7	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.68056782
8	Propanoate metabolism_Homo sapiens_hsa00640	2.63196896
9	Glucagon signaling pathway_Homo sapiens_hsa04922	2.59120977
10	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.30925416
11	Basal transcription factors_Homo sapiens_hsa03022	2.25610273
12	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.11732457
13	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.07243993
14	Glycerolipid metabolism_Homo sapiens_hsa00561	2.04512972
15	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.02806922
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.97420059
17	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.86435814
18	PPAR signaling pathway_Homo sapiens_hsa03320	1.81579925
19	Pentose phosphate pathway_Homo sapiens_hsa00030	1.70107749
20	Oocyte meiosis_Homo sapiens_hsa04114	1.69686161
21	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.65790323
22	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.61495772
23	Mineral absorption_Homo sapiens_hsa04978	1.60764271
24	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.55636688
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.49927286
26	Amphetamine addiction_Homo sapiens_hsa05031	1.39361978
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.39353074
28	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.37301132
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.37284313
30	Carbon metabolism_Homo sapiens_hsa01200	1.35967063
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.33596781
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.31637668
33	Collecting duct acid secretion_Homo sapiens_hsa04966	1.28255092
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.27522856
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.24799802
36	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.22783882
37	Fatty acid degradation_Homo sapiens_hsa00071	1.19874719
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19370988
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.17443921
40	Glutathione metabolism_Homo sapiens_hsa00480	1.16108153
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08135200
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.06903772
43	Antigen processing and presentation_Homo sapiens_hsa04612	1.03916979
44	Renin secretion_Homo sapiens_hsa04924	1.03142633
45	Purine metabolism_Homo sapiens_hsa00230	1.01791499
46	Huntingtons disease_Homo sapiens_hsa05016	1.01602388
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.86238583
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.82220840
49	mRNA surveillance pathway_Homo sapiens_hsa03015	0.81483008
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79699068
51	Insulin secretion_Homo sapiens_hsa04911	0.78930584
52	Bile secretion_Homo sapiens_hsa04976	0.75578778
53	Sulfur metabolism_Homo sapiens_hsa00920	0.69827023
54	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69192638
55	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.68555808
56	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.68127183
57	Estrogen signaling pathway_Homo sapiens_hsa04915	0.64886878
58	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.63606238
59	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.61523252
60	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.60786847
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60686666
62	RNA transport_Homo sapiens_hsa03013	0.60536870
63	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.60170163
64	Renin-angiotensin system_Homo sapiens_hsa04614	0.60006836
65	Long-term potentiation_Homo sapiens_hsa04720	0.58869324
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.55633980
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.55099025
68	Pancreatic secretion_Homo sapiens_hsa04972	0.54572853
69	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54305961
70	ABC transporters_Homo sapiens_hsa02010	0.54249199
71	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.52762652
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.52342036
73	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.51985337
74	Legionellosis_Homo sapiens_hsa05134	0.51761744
75	Salivary secretion_Homo sapiens_hsa04970	0.49153212
76	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.48273777
77	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.48191307
78	Gastric acid secretion_Homo sapiens_hsa04971	0.45702845
79	Taste transduction_Homo sapiens_hsa04742	0.41669363
80	Metabolic pathways_Homo sapiens_hsa01100	0.41636567
81	Endocytosis_Homo sapiens_hsa04144	0.38198133
82	AMPK signaling pathway_Homo sapiens_hsa04152	0.37354469
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35258142
84	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.33390492
85	cAMP signaling pathway_Homo sapiens_hsa04024	0.32408298
86	VEGF signaling pathway_Homo sapiens_hsa04370	0.29637852
87	Circadian entrainment_Homo sapiens_hsa04713	0.27090434
88	Alcoholism_Homo sapiens_hsa05034	0.23332101
89	Pyrimidine metabolism_Homo sapiens_hsa00240	0.21379417
90	Retinol metabolism_Homo sapiens_hsa00830	0.20506404
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.17964263
92	Cocaine addiction_Homo sapiens_hsa05030	0.15014584
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.13318456
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.12951279
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.10710846
96	Wnt signaling pathway_Homo sapiens_hsa04310	0.10508980
97	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.09521965
98	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.06968448
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.05561716
100	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.04809439

TEX33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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