ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	9.43468927
2	spermatid development (GO:0007286)	9.24798028
3	motile cilium assembly (GO:0044458)	9.19936579
4	cilium movement (GO:0003341)	8.30195241
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	8.07631582
6	regulation of cilium movement (GO:0003352)	7.87237057
7	single fertilization (GO:0007338)	7.83413673
8	male meiosis (GO:0007140)	7.38656811
9	piRNA metabolic process (GO:0034587)	7.20262339
10	synaptonemal complex assembly (GO:0007130)	7.08450361
11	synaptonemal complex organization (GO:0070193)	7.07153850
12	sperm capacitation (GO:0048240)	6.85518405
13	fertilization (GO:0009566)	6.53766025
14	spermatogenesis (GO:0007283)	6.44961100
15	male gamete generation (GO:0048232)	6.42651858
16	microtubule depolymerization (GO:0007019)	6.41313241
17	negative regulation of inclusion body assembly (GO:0090084)	5.97475477
18	gamete generation (GO:0007276)	5.91791064
19	organic cation transport (GO:0015695)	5.76298989
20	calcium ion-dependent exocytosis (GO:0017156)	5.33223979
21	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.32758434
22	cell recognition (GO:0008037)	5.26604997
23	ventricular system development (GO:0021591)	5.25620524
24	germ cell development (GO:0007281)	5.17513404
25	regulation of inclusion body assembly (GO:0090083)	5.10515858
26	glycerol ether metabolic process (GO:0006662)	4.99107091
27	chromosome organization involved in meiosis (GO:0070192)	4.91940740
28	microtubule severing (GO:0051013)	4.82639359
29	spermatid nucleus differentiation (GO:0007289)	4.80301306
30	DNA methylation involved in gamete generation (GO:0043046)	4.72841528
31	regulation of microtubule-based movement (GO:0060632)	4.66299942
32	multicellular organismal reproductive process (GO:0048609)	4.64063750
33	ether metabolic process (GO:0018904)	4.61236547
34	seminiferous tubule development (GO:0072520)	4.47606762
35	male meiosis I (GO:0007141)	4.38871736
36	chromosome condensation (GO:0030261)	4.24519075
37	monoubiquitinated protein deubiquitination (GO:0035520)	4.15210394
38	sequestering of actin monomers (GO:0042989)	4.14141501
39	chaperone-mediated protein complex assembly (GO:0051131)	4.13721963
40	meiotic nuclear division (GO:0007126)	4.13323553
41	protein K11-linked deubiquitination (GO:0035871)	3.96841174
42	DNA packaging (GO:0006323)	3.96216624
43	GTP biosynthetic process (GO:0006183)	3.88765998
44	left/right pattern formation (GO:0060972)	3.84716526
45	multicellular organismal development (GO:0007275)	3.77335749
46	genitalia morphogenesis (GO:0035112)	3.71725129
47	protein polyglutamylation (GO:0018095)	3.56069312
48	nucleoside diphosphate phosphorylation (GO:0006165)	3.51484436
49	meiosis I (GO:0007127)	3.46987503
50	UTP biosynthetic process (GO:0006228)	3.46849765
51	single strand break repair (GO:0000012)	3.43825969
52	microtubule polymerization or depolymerization (GO:0031109)	3.43266103
53	sexual reproduction (GO:0019953)	3.31414913
54	polyol catabolic process (GO:0046174)	3.29147154
55	lactate metabolic process (GO:0006089)	3.22592876
56	protein localization to cilium (GO:0061512)	3.20975953
57	meiotic cell cycle (GO:0051321)	3.18216785
58	alditol metabolic process (GO:0019400)	3.17406066
59	UTP metabolic process (GO:0046051)	3.15564588
60	regulation of spindle checkpoint (GO:0090231)	3.09528943
61	synapsis (GO:0007129)	3.04234437
62	glycolytic process (GO:0006096)	3.00844139
63	intraciliary transport (GO:0042073)	2.93338009
64	amino-acid betaine transport (GO:0015838)	2.92550513
65	carnitine transport (GO:0015879)	2.92550513
66	cellular component assembly involved in morphogenesis (GO:0010927)	2.88818082
67	cilium morphogenesis (GO:0060271)	2.87695559
68	cilium organization (GO:0044782)	2.87154305
69	microtubule-based movement (GO:0007018)	2.86138414
70	axoneme assembly (GO:0035082)	2.82020450
71	carnitine transmembrane transport (GO:1902603)	2.80432346
72	mitotic sister chromatid cohesion (GO:0007064)	2.79321890
73	glycerol metabolic process (GO:0006071)	2.76803640
74	cilium assembly (GO:0042384)	2.74962504
75	protein refolding (GO:0042026)	2.71217366
76	meiotic cell cycle process (GO:1903046)	2.69280792
77	guanosine-containing compound biosynthetic process (GO:1901070)	2.69221132
78	positive regulation of macrophage activation (GO:0043032)	2.65663393
79	interferon-gamma secretion (GO:0072643)	2.62888036
80	negative regulation of organelle assembly (GO:1902116)	2.62354027
81	CTP metabolic process (GO:0046036)	2.61016159
82	CTP biosynthetic process (GO:0006241)	2.61016159
83	nucleus organization (GO:0006997)	2.60643788
84	centriole assembly (GO:0098534)	2.58820081
85	cell redox homeostasis (GO:0045454)	2.54221423
86	gene silencing by RNA (GO:0031047)	2.51935409
87	fusion of sperm to egg plasma membrane (GO:0007342)	14.9536546
88	cell wall macromolecule metabolic process (GO:0044036)	13.7521268
89	cell wall macromolecule catabolic process (GO:0016998)	13.7521268
90	acrosome assembly (GO:0001675)	13.7461714
91	sperm motility (GO:0030317)	13.2726373
92	sperm-egg recognition (GO:0035036)	12.0708743
93	multicellular organism reproduction (GO:0032504)	12.0699361
94	plasma membrane fusion (GO:0045026)	11.4156659
95	acrosome reaction (GO:0007340)	11.2737364
96	binding of sperm to zona pellucida (GO:0007339)	11.0096192
97	cell-cell recognition (GO:0009988)	10.8077265
98	axonemal dynein complex assembly (GO:0070286)	10.1707258
99	reproduction (GO:0000003)	10.1242057
100	epithelial cilium movement (GO:0003351)	10.0701933

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.49883796
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.90709936
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.97145862
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.36460565
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.09274885
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.96362600
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.85706609
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.67581119
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.28608360
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.23548322
11	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.18789303
12	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	2.10756726
13	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.07474675
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.01683370
15	VDR_22108803_ChIP-Seq_LS180_Human	1.99731335
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.96970116
17	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.92167733
18	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.90303178
19	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.84698140
20	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.78462120
21	STAT1_17558387_ChIP-Seq_HELA_Human	1.73636620
22	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.68962416
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66713008
24	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.64639032
25	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.64327060
26	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.63171956
27	KDM2B_26808549_Chip-Seq_REH_Human	1.61272927
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58212794
29	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.56640095
30	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.53625467
31	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.51390116
32	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49058199
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46896853
34	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.46281925
35	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.45658735
36	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.43638697
37	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.41892201
38	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.39078148
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36528404
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35775798
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.34954208
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34954208
43	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34524788
44	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32887698
45	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.32068044
46	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.31780634
47	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.31401881
48	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.26016560
49	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.24186816
50	P53_21459846_ChIP-Seq_SAOS-2_Human	1.23640093
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.23620223
52	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.23513081
53	GF1_26923725_Chip-Seq_HPCs_Mouse	1.22960018
54	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.20092909
55	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17849235
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17535352
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.17499841
58	P53_22387025_ChIP-Seq_ESCs_Mouse	1.16943892
59	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.16829022
60	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16592654
61	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.14001231
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.12240080
63	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.12176960
64	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.11014300
65	P300_18555785_Chip-Seq_ESCs_Mouse	1.10439877
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10194743
67	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.09717362
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08774581
69	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07996805
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07996805
71	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.05785112
72	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.05150567
73	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.04869956
74	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.04329373
75	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03424750
76	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.02983752
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02916156
78	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.02781886
79	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.01726807
80	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01464707
81	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.01403613
82	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.00407821
83	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.98350649
84	ERG_20517297_ChIP-Seq_VCAP_Human	0.97807597
85	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96643772
86	SOX9_26525672_Chip-Seq_HEART_Mouse	0.96576836
87	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95699318
88	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.94750054
89	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.92964259
90	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.92711596
91	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.91706306
92	PU1_27457419_Chip-Seq_LIVER_Mouse	0.90803952
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.90678248
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.89667902
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89363445
96	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.88400473
97	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.87898534
98	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.87423433
99	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.87184441
100	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.86079473

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.08805726
2	MP0001929_abnormal_gametogenesis	5.65094701
3	MP0008877_abnormal_DNA_methylation	4.45067017
4	MP0002210_abnormal_sex_determination	3.47514258
5	MP0002161_abnormal_fertility/fecundity	3.29554384
6	MP0001145_abnormal_male_reproductive	2.96393026
7	MP0000653_abnormal_sex_gland	2.59089297
8	MP0002653_abnormal_ependyma_morphology	2.37494026
9	MP0005670_abnormal_white_adipose	2.36778918
10	MP0005410_abnormal_fertilization	16.3772114
11	MP0005623_abnormal_meninges_morphology	1.72976213
12	MP0002160_abnormal_reproductive_system	1.55530883
13	MP0003646_muscle_fatigue	1.51598228
14	MP0002282_abnormal_trachea_morphology	1.39296313
15	MP0001765_abnormal_ion_homeostasis	1.18974879
16	MP0009046_muscle_twitch	1.15337860
17	MP0005647_abnormal_sex_gland	1.14648381
18	MP0004233_abnormal_muscle_weight	1.13859787
19	MP0008058_abnormal_DNA_repair	1.07106820
20	MP0008057_abnormal_DNA_replication	0.98136913
21	MP0001984_abnormal_olfaction	0.93587841
22	MP0003011_delayed_dark_adaptation	0.86168417
23	MP0005389_reproductive_system_phenotype	0.80147527
24	MP0002234_abnormal_pharynx_morphology	0.80020129
25	MP0008995_early_reproductive_senescence	0.70480880
26	MP0000569_abnormal_digit_pigmentation	0.63515167
27	MP0005636_abnormal_mineral_homeostasis	0.63220650
28	MP0004036_abnormal_muscle_relaxation	0.59577052
29	MP0010094_abnormal_chromosome_stability	0.58475681
30	MP0002139_abnormal_hepatobiliary_system	0.53420264
31	MP0003950_abnormal_plasma_membrane	0.52847725
32	MP0005253_abnormal_eye_physiology	0.52107886
33	MP0004134_abnormal_chest_morphology	0.50911535
34	MP0001324_abnormal_eye_pigmentation	0.49343782
35	MP0003329_amyloid_beta_deposits	0.48902071
36	MP0003699_abnormal_female_reproductive	0.48706614
37	MP0003786_premature_aging	0.48024675
38	MP0005551_abnormal_eye_electrophysiolog	0.47988478
39	MP0002736_abnormal_nociception_after	0.44337947
40	MP0004019_abnormal_vitamin_homeostasis	0.44172752
41	MP0003115_abnormal_respiratory_system	0.43927032
42	MP0005377_hearing/vestibular/ear_phenot	0.43663410
43	MP0003878_abnormal_ear_physiology	0.43663410
44	MP0005666_abnormal_adipose_tissue	0.41816955
45	MP0001545_abnormal_hematopoietic_system	0.40604056
46	MP0005397_hematopoietic_system_phenotyp	0.40604056
47	MP0002102_abnormal_ear_morphology	0.39304909
48	MP0004133_heterotaxia	0.38308018
49	MP0006072_abnormal_retinal_apoptosis	0.38261789
50	MP0003633_abnormal_nervous_system	0.37154728
51	MP0008007_abnormal_cellular_replicative	0.37136641
52	MP0002269_muscular_atrophy	0.35912919
53	MP0001764_abnormal_homeostasis	0.35032448
54	MP0001119_abnormal_female_reproductive	0.34765507
55	MP0000358_abnormal_cell_content/	0.34373662
56	MP0002928_abnormal_bile_duct	0.33298169
57	MP0005391_vision/eye_phenotype	0.31675866
58	MP0001293_anophthalmia	0.30020706
59	MP0006036_abnormal_mitochondrial_physio	0.28948605
60	MP0010307_abnormal_tumor_latency	0.28145849
61	MP0004084_abnormal_cardiac_muscle	0.27460207
62	MP0003631_nervous_system_phenotype	0.27322398
63	MP0000604_amyloidosis	0.25218022
64	MP0009115_abnormal_fat_cell	0.24001440
65	MP0001968_abnormal_touch/_nociception	0.23641233
66	MP0002971_abnormal_brown_adipose	0.23260642
67	MP0004811_abnormal_neuron_physiology	0.22747776
68	MP0000534_abnormal_ureter_morphology	0.22232290
69	MP0003861_abnormal_nervous_system	0.22089382
70	MP0009278_abnormal_bone_marrow	0.21633864
71	MP0002152_abnormal_brain_morphology	0.21422875
72	MP0009250_abnormal_appendicular_skeleto	0.20536372
73	MP0004808_abnormal_hematopoietic_stem	0.20449602
74	MP0002169_no_abnormal_phenotype	0.20389259
75	MP0001730_embryonic_growth_arrest	0.20323062
76	MP0002873_normal_phenotype	0.20298189
77	MP0004043_abnormal_pH_regulation	0.19879486
78	MP0000751_myopathy	0.19847925
79	MP0001727_abnormal_embryo_implantation	0.18964124
80	MP0004145_abnormal_muscle_electrophysio	0.18265190
81	MP0002295_abnormal_pulmonary_circulatio	0.17288865
82	MP0005503_abnormal_tendon_morphology	0.17152960
83	MP0000462_abnormal_digestive_system	0.16810121
84	MP0002909_abnormal_adrenal_gland	0.15930632
85	MP0008875_abnormal_xenobiotic_pharmacok	0.15112110
86	MP0005195_abnormal_posterior_eye	0.15061512
87	MP0000432_abnormal_head_morphology	0.14598624
88	MP0002229_neurodegeneration	0.14081546
89	MP0003111_abnormal_nucleus_morphology	0.14047616
90	MP0005319_abnormal_enzyme/_coenzyme	0.13987743
91	MP0003948_abnormal_gas_homeostasis	0.13526050
92	MP0003942_abnormal_urinary_system	0.13472171
93	MP0000001_mammalian_phenotype	0.12908863
94	MP0002109_abnormal_limb_morphology	0.12836215
95	MP0005365_abnormal_bile_salt	0.11813997
96	MP0000313_abnormal_cell_death	0.11742831
97	MP0003879_abnormal_hair_cell	0.11449003
98	MP0000427_abnormal_hair_cycle	0.11084304
99	MP0009697_abnormal_copulation	0.11035989
100	MP0002084_abnormal_developmental_patter	0.10927038

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory epithelium morphology (HP:0012253)	9.44586672
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.44586672
3	Abnormal ciliary motility (HP:0012262)	8.34521568
4	Chronic bronchitis (HP:0004469)	8.07020361
5	Rhinitis (HP:0012384)	7.80899699
6	Infertility (HP:0000789)	6.48664901
7	Nasal polyposis (HP:0100582)	6.23672596
8	Abnormality of the nasal mucosa (HP:0000433)	5.12811519
9	Bronchitis (HP:0012387)	4.61758568
10	Bronchiectasis (HP:0002110)	4.43014626
11	Male infertility (HP:0003251)	4.18555226
12	Recurrent sinusitis (HP:0011108)	3.98622660
13	Nephronophthisis (HP:0000090)	3.80754333
14	Recurrent otitis media (HP:0000403)	3.35897219
15	Abnormal spermatogenesis (HP:0008669)	3.19264897
16	Abnormality of the renal medulla (HP:0100957)	2.85924986
17	Medial flaring of the eyebrow (HP:0010747)	2.56965958
18	Abnormality of midbrain morphology (HP:0002418)	2.53632056
19	Molar tooth sign on MRI (HP:0002419)	2.53632056
20	Tubulointerstitial nephritis (HP:0001970)	2.51317009
21	Tubular atrophy (HP:0000092)	2.37447583
22	Recurrent bronchitis (HP:0002837)	2.31584039
23	Tubulointerstitial abnormality (HP:0001969)	2.22572884
24	Gonadotropin excess (HP:0000837)	2.11219693
25	Azoospermia (HP:0000027)	2.02705009
26	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	14.0970524
27	Absent/shortened dynein arms (HP:0200106)	13.8639584
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.8639584
29	Abnormal respiratory motile cilium physiology (HP:0012261)	10.1043674
30	Fibular hypoplasia (HP:0003038)	1.87255852
31	Tubulointerstitial fibrosis (HP:0005576)	1.84861597
32	Impulsivity (HP:0100710)	1.82350537
33	Dyschromatopsia (HP:0007641)	1.80204405
34	Abnormality of permanent molar morphology (HP:0011071)	1.69358511
35	Abnormality of the dental root (HP:0006486)	1.69358511
36	Taurodontia (HP:0000679)	1.69358511
37	Decreased central vision (HP:0007663)	1.69061535
38	Stage 5 chronic kidney disease (HP:0003774)	1.69033982
39	Postaxial foot polydactyly (HP:0001830)	1.68381008
40	Abnormality of the renal cortex (HP:0011035)	1.68163971
41	Abnormal drinking behavior (HP:0030082)	1.63564037
42	Polydipsia (HP:0001959)	1.63564037
43	Abnormality of renal excretion (HP:0011036)	1.61629403
44	Congenital hepatic fibrosis (HP:0002612)	1.59898538
45	Cholecystitis (HP:0001082)	1.59424137
46	Abnormal gallbladder physiology (HP:0012438)	1.59424137
47	Abnormality of molar morphology (HP:0011070)	1.57493919
48	Abnormality of molar (HP:0011077)	1.57493919
49	Abnormality of the dental pulp (HP:0006479)	1.57172433
50	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.54993727
51	Chronic sinusitis (HP:0011109)	1.53473484
52	Gait imbalance (HP:0002141)	1.51436859
53	Abnormality of dentin (HP:0010299)	1.51217271
54	Congenital primary aphakia (HP:0007707)	1.50376366
55	Absent frontal sinuses (HP:0002688)	1.49628237
56	Microglossia (HP:0000171)	1.49608881
57	Short ribs (HP:0000773)	1.48227850
58	Abnormality of the lower motor neuron (HP:0002366)	1.44797348
59	Aplasia/Hypoplasia of the lens (HP:0008063)	1.41616691
60	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.41032057
61	Absent epiphyses (HP:0010577)	1.41032057
62	Pancreatic fibrosis (HP:0100732)	1.40625007
63	Oculomotor apraxia (HP:0000657)	1.39863639
64	Postaxial hand polydactyly (HP:0001162)	1.39390793
65	Choroideremia (HP:0001139)	1.38465761
66	Vascular calcification (HP:0004934)	1.35459415
67	Cystic liver disease (HP:0006706)	1.33435524
68	Spastic tetraparesis (HP:0001285)	1.32830468
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.30832408
70	Renal dysplasia (HP:0000110)	1.29624676
71	Facial cleft (HP:0002006)	1.28161451
72	J-shaped sella turcica (HP:0002680)	1.27438809
73	Amyotrophic lateral sclerosis (HP:0007354)	1.25644371
74	Nephrogenic diabetes insipidus (HP:0009806)	1.24967189
75	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.24357642
76	Heterotopia (HP:0002282)	1.23370906
77	Asymmetric septal hypertrophy (HP:0001670)	1.22404432
78	Cardiovascular calcification (HP:0011915)	1.21560293
79	Genital tract atresia (HP:0001827)	1.19886556
80	Abnormal urine output (HP:0012590)	1.19621731
81	Short femoral neck (HP:0100864)	1.19484014
82	Hemorrhage of the eye (HP:0011885)	1.18262072
83	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.17927339
84	Deformed sella turcica (HP:0002681)	1.16542898
85	Bell-shaped thorax (HP:0001591)	1.16441868
86	Abnormal biliary tract physiology (HP:0012439)	1.16432553
87	Bile duct proliferation (HP:0001408)	1.16432553
88	Neurofibrillary tangles (HP:0002185)	1.16258910
89	Abnormality of saccadic eye movements (HP:0000570)	1.15568726
90	Vaginal atresia (HP:0000148)	1.15025415
91	Median cleft lip (HP:0000161)	1.13306113
92	True hermaphroditism (HP:0010459)	1.13148914
93	Congenital malformation of the right heart (HP:0011723)	1.13004236
94	Double outlet right ventricle (HP:0001719)	1.13004236
95	Bundle branch block (HP:0011710)	1.10472048
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.10406159
97	Breast carcinoma (HP:0003002)	1.09166411
98	Constricted visual fields (HP:0001133)	1.08841044
99	Poor coordination (HP:0002370)	1.08040108
100	Exercise-induced myalgia (HP:0003738)	1.06613458

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK4	9.15946928
2	PDK3	9.15946928
3	PDK2	5.93188082
4	TESK1	4.85063869
5	PRKD3	4.00062849
6	ICK	3.28081594
7	PTK2B	2.27052145
8	STK39	2.22676655
9	WNK4	2.19213980
10	PNCK	1.86819025
11	STK38	1.52199724
12	NEK2	1.50235728
13	PDK1	1.20096605
14	DYRK1B	1.10002675
15	IRAK1	0.86895723
16	TYRO3	0.84373508
17	DYRK3	0.82643381
18	WNK1	0.79354802
19	PASK	0.75075414
20	MAPK15	0.68347360
21	TESK2	0.65922213
22	PDPK1	0.64464038
23	CCNB1	0.62599688
24	STK3	0.61960780
25	TTK	0.61267570
26	STK38L	0.59387039
27	LMTK2	0.59087972
28	EEF2K	0.58708862
29	PINK1	0.57462105
30	CHEK2	0.52420860
31	MAP2K6	0.51233129
32	RIPK4	0.46220220
33	CAMK1G	0.38989121
34	IRAK2	0.38511913
35	CHEK1	0.36704873
36	WEE1	0.35872774
37	NTRK2	0.35131967
38	MAPKAPK5	0.33628878
39	MAP3K10	0.32492798
40	MUSK	0.31799150
41	PRKCG	0.31298842
42	PAK1	0.30599935
43	CAMKK1	0.29553949
44	BRSK2	0.27827973
45	PRKG2	0.27485131
46	ATM	0.25626487
47	ATR	0.22864455
48	PLK4	0.22155164
49	MARK2	0.19726306
50	MARK3	0.18202443
51	CDK15	0.17436257
52	NEK6	0.17367215
53	PLK1	0.17088006
54	PAK2	0.17067597
55	PRKAA1	0.16442967
56	RPS6KB1	0.14859037
57	CDK18	0.14757805
58	PKN1	0.14509896
59	PRKG1	0.13367250
60	CDK11A	0.12816729
61	MTOR	0.12323370
62	STK10	0.11802508
63	PRKCQ	0.11385784
64	CDC7	0.11237083
65	BRAF	0.11184942
66	PRKACG	0.11023266
67	PRKCZ	0.10946318
68	CDK14	0.10564050
69	WNK3	0.07818621
70	BRSK1	0.07626857
71	CSNK2A1	0.07371425
72	MAP3K4	0.07271002
73	DDR2	0.07164368
74	CSF1R	0.06831744
75	CAMK2A	0.04896750
76	PAK4	0.04614769
77	RPS6KA1	0.03942022
78	STK11	0.03240895
79	CSNK1D	0.02934574
80	MAPK8	0.02624542
81	CSNK2A2	0.02088304
82	CDK1	0.01987387
83	MAP2K7	0.01800426
84	PRKCA	0.01750291
85	GSK3B	0.01570613
86	PRKCD	0.01199898
87	EGFR	0.00891388
88	PRKACA	0.00549639
89	CDK2	0.00073373
90	RPS6KA3	-0.0278862
91	PRKDC	-0.0223471
92	MINK1	-0.0194027
93	MARK1	-0.0191972
94	MET	-0.0165758
95	PDGFRB	-0.0136653
96	MAP3K5	-0.0105077
97	AURKA	-0.0103768
98	OXSR1	-0.0103468
99	PRKCB	-0.0045970
100	PAK6	-0.0040432

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.37367434
2	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.41144764
3	Pyruvate metabolism_Homo sapiens_hsa00620	4.17440432
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.91447805
5	Propanoate metabolism_Homo sapiens_hsa00640	3.49374526
6	Glucagon signaling pathway_Homo sapiens_hsa04922	2.90063311
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.59083971
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.54534695
9	Pentose phosphate pathway_Homo sapiens_hsa00030	2.50968164
10	Basal transcription factors_Homo sapiens_hsa03022	2.41752796
11	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.29441626
12	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.18423643
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.96765510
14	PPAR signaling pathway_Homo sapiens_hsa03320	1.89638679
15	Glycerolipid metabolism_Homo sapiens_hsa00561	1.88923483
16	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.78753883
17	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.77724574
18	Oocyte meiosis_Homo sapiens_hsa04114	1.76941895
19	Amphetamine addiction_Homo sapiens_hsa05031	1.70474398
20	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.62310876
21	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.62007511
22	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.52653370
23	Carbon metabolism_Homo sapiens_hsa01200	1.44819721
24	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.44629375
25	Renin secretion_Homo sapiens_hsa04924	1.42235477
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37903519
27	Mineral absorption_Homo sapiens_hsa04978	1.36437124
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.26443897
29	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.25774777
30	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.23274021
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.22070694
32	Fat digestion and absorption_Homo sapiens_hsa04975	1.13999453
33	Fatty acid degradation_Homo sapiens_hsa00071	1.12018460
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.11513739
35	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.10902007
36	Huntingtons disease_Homo sapiens_hsa05016	1.10641725
37	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.07937756
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02604203
39	Purine metabolism_Homo sapiens_hsa00230	1.02514004
40	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.99867892
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.99331521
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98569635
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93499010
44	Glutathione metabolism_Homo sapiens_hsa00480	0.90886099
45	Long-term potentiation_Homo sapiens_hsa04720	0.85913604
46	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.82017900
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79226410
48	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.75571278
49	Insulin secretion_Homo sapiens_hsa04911	0.74924094
50	Renin-angiotensin system_Homo sapiens_hsa04614	0.74305106
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.71828786
52	Antigen processing and presentation_Homo sapiens_hsa04612	0.68772133
53	RNA transport_Homo sapiens_hsa03013	0.64110426
54	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.63441328
55	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.61556608
56	Estrogen signaling pathway_Homo sapiens_hsa04915	0.58995556
57	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.58364524
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.58247140
59	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57700339
60	Bile secretion_Homo sapiens_hsa04976	0.56560647
61	Sulfur metabolism_Homo sapiens_hsa00920	0.55844997
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55393481
63	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.52161087
64	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51290795
65	Protein digestion and absorption_Homo sapiens_hsa04974	0.50662474
66	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.50010642
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46158585
68	VEGF signaling pathway_Homo sapiens_hsa04370	0.44910045
69	Pancreatic secretion_Homo sapiens_hsa04972	0.44730508
70	Salivary secretion_Homo sapiens_hsa04970	0.43037877
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.42348829
72	Metabolic pathways_Homo sapiens_hsa01100	0.41803039
73	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39062460
74	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.37993312
75	AMPK signaling pathway_Homo sapiens_hsa04152	0.37727009
76	ABC transporters_Homo sapiens_hsa02010	0.36299880
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35743503
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35125698
79	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34915405
80	Gastric acid secretion_Homo sapiens_hsa04971	0.32359840
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.32345713
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31061050
83	Endocytosis_Homo sapiens_hsa04144	0.30030402
84	Cocaine addiction_Homo sapiens_hsa05030	0.29792971
85	Olfactory transduction_Homo sapiens_hsa04740	0.28672272
86	Circadian entrainment_Homo sapiens_hsa04713	0.26957065
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.25680167
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25554468
89	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.23659814
90	Taste transduction_Homo sapiens_hsa04742	0.23626485
91	Legionellosis_Homo sapiens_hsa05134	0.22152858
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.19011012
93	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.18555446
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.18232626
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.15618946
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.15546655
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.15503149
98	Alcoholism_Homo sapiens_hsa05034	0.13847951
99	Retinol metabolism_Homo sapiens_hsa00830	0.08905412
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.07262835

TEX36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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