TEX36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.43468927
2spermatid development (GO:0007286)9.24798028
3motile cilium assembly (GO:0044458)9.19936579
4cilium movement (GO:0003341)8.30195241
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.07631582
6regulation of cilium movement (GO:0003352)7.87237057
7single fertilization (GO:0007338)7.83413673
8male meiosis (GO:0007140)7.38656811
9piRNA metabolic process (GO:0034587)7.20262339
10synaptonemal complex assembly (GO:0007130)7.08450361
11synaptonemal complex organization (GO:0070193)7.07153850
12sperm capacitation (GO:0048240)6.85518405
13fertilization (GO:0009566)6.53766025
14spermatogenesis (GO:0007283)6.44961100
15male gamete generation (GO:0048232)6.42651858
16microtubule depolymerization (GO:0007019)6.41313241
17negative regulation of inclusion body assembly (GO:0090084)5.97475477
18gamete generation (GO:0007276)5.91791064
19organic cation transport (GO:0015695)5.76298989
20calcium ion-dependent exocytosis (GO:0017156)5.33223979
21cellular process involved in reproduction in multicellular organism (GO:0022412)5.32758434
22cell recognition (GO:0008037)5.26604997
23ventricular system development (GO:0021591)5.25620524
24germ cell development (GO:0007281)5.17513404
25regulation of inclusion body assembly (GO:0090083)5.10515858
26glycerol ether metabolic process (GO:0006662)4.99107091
27chromosome organization involved in meiosis (GO:0070192)4.91940740
28microtubule severing (GO:0051013)4.82639359
29spermatid nucleus differentiation (GO:0007289)4.80301306
30DNA methylation involved in gamete generation (GO:0043046)4.72841528
31regulation of microtubule-based movement (GO:0060632)4.66299942
32multicellular organismal reproductive process (GO:0048609)4.64063750
33ether metabolic process (GO:0018904)4.61236547
34seminiferous tubule development (GO:0072520)4.47606762
35male meiosis I (GO:0007141)4.38871736
36chromosome condensation (GO:0030261)4.24519075
37monoubiquitinated protein deubiquitination (GO:0035520)4.15210394
38sequestering of actin monomers (GO:0042989)4.14141501
39chaperone-mediated protein complex assembly (GO:0051131)4.13721963
40meiotic nuclear division (GO:0007126)4.13323553
41protein K11-linked deubiquitination (GO:0035871)3.96841174
42DNA packaging (GO:0006323)3.96216624
43GTP biosynthetic process (GO:0006183)3.88765998
44left/right pattern formation (GO:0060972)3.84716526
45multicellular organismal development (GO:0007275)3.77335749
46genitalia morphogenesis (GO:0035112)3.71725129
47protein polyglutamylation (GO:0018095)3.56069312
48nucleoside diphosphate phosphorylation (GO:0006165)3.51484436
49meiosis I (GO:0007127)3.46987503
50UTP biosynthetic process (GO:0006228)3.46849765
51single strand break repair (GO:0000012)3.43825969
52microtubule polymerization or depolymerization (GO:0031109)3.43266103
53sexual reproduction (GO:0019953)3.31414913
54polyol catabolic process (GO:0046174)3.29147154
55lactate metabolic process (GO:0006089)3.22592876
56protein localization to cilium (GO:0061512)3.20975953
57meiotic cell cycle (GO:0051321)3.18216785
58alditol metabolic process (GO:0019400)3.17406066
59UTP metabolic process (GO:0046051)3.15564588
60regulation of spindle checkpoint (GO:0090231)3.09528943
61synapsis (GO:0007129)3.04234437
62glycolytic process (GO:0006096)3.00844139
63intraciliary transport (GO:0042073)2.93338009
64amino-acid betaine transport (GO:0015838)2.92550513
65carnitine transport (GO:0015879)2.92550513
66cellular component assembly involved in morphogenesis (GO:0010927)2.88818082
67cilium morphogenesis (GO:0060271)2.87695559
68cilium organization (GO:0044782)2.87154305
69microtubule-based movement (GO:0007018)2.86138414
70axoneme assembly (GO:0035082)2.82020450
71carnitine transmembrane transport (GO:1902603)2.80432346
72mitotic sister chromatid cohesion (GO:0007064)2.79321890
73glycerol metabolic process (GO:0006071)2.76803640
74cilium assembly (GO:0042384)2.74962504
75protein refolding (GO:0042026)2.71217366
76meiotic cell cycle process (GO:1903046)2.69280792
77guanosine-containing compound biosynthetic process (GO:1901070)2.69221132
78positive regulation of macrophage activation (GO:0043032)2.65663393
79interferon-gamma secretion (GO:0072643)2.62888036
80negative regulation of organelle assembly (GO:1902116)2.62354027
81CTP metabolic process (GO:0046036)2.61016159
82CTP biosynthetic process (GO:0006241)2.61016159
83nucleus organization (GO:0006997)2.60643788
84centriole assembly (GO:0098534)2.58820081
85cell redox homeostasis (GO:0045454)2.54221423
86gene silencing by RNA (GO:0031047)2.51935409
87fusion of sperm to egg plasma membrane (GO:0007342)14.9536546
88cell wall macromolecule catabolic process (GO:0016998)13.7521268
89cell wall macromolecule metabolic process (GO:0044036)13.7521268
90acrosome assembly (GO:0001675)13.7461714
91sperm motility (GO:0030317)13.2726373
92sperm-egg recognition (GO:0035036)12.0708743
93multicellular organism reproduction (GO:0032504)12.0699361
94plasma membrane fusion (GO:0045026)11.4156659
95acrosome reaction (GO:0007340)11.2737364
96binding of sperm to zona pellucida (GO:0007339)11.0096192
97cell-cell recognition (GO:0009988)10.8077265
98axonemal dynein complex assembly (GO:0070286)10.1707258
99reproduction (GO:0000003)10.1242057
100epithelial cilium movement (GO:0003351)10.0701933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.49883796
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.90709936
3EZH2_22144423_ChIP-Seq_EOC_Human3.97145862
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.36460565
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.09274885
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.96362600
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85706609
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.67581119
9ZNF274_21170338_ChIP-Seq_K562_Hela2.28608360
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23548322
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18789303
12KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.10756726
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07474675
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.01683370
15VDR_22108803_ChIP-Seq_LS180_Human1.99731335
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96970116
17RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.92167733
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.90303178
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.84698140
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.78462120
21STAT1_17558387_ChIP-Seq_HELA_Human1.73636620
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68962416
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66713008
24GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.64639032
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.64327060
26KAP1_22055183_ChIP-Seq_ESCs_Mouse1.63171956
27KDM2B_26808549_Chip-Seq_REH_Human1.61272927
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58212794
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.56640095
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53625467
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.51390116
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49058199
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46896853
34SOX2_22085726_ChIP-Seq_NPCs_Mouse1.46281925
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.45658735
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43638697
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.41892201
38FLI1_21867929_ChIP-Seq_TH2_Mouse1.39078148
39RNF2_27304074_Chip-Seq_NSC_Mouse1.36528404
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35775798
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34954208
42CBP_20019798_ChIP-Seq_JUKART_Human1.34954208
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34524788
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32887698
45GATA3_21867929_ChIP-Seq_TH1_Mouse1.32068044
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.31780634
47LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31401881
48CRX_20693478_ChIP-Seq_RETINA_Mouse1.26016560
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24186816
50P53_21459846_ChIP-Seq_SAOS-2_Human1.23640093
51REST_21632747_ChIP-Seq_MESCs_Mouse1.23620223
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23513081
53GF1_26923725_Chip-Seq_HPCs_Mouse1.22960018
54CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20092909
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17849235
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17535352
57TAF15_26573619_Chip-Seq_HEK293_Human1.17499841
58P53_22387025_ChIP-Seq_ESCs_Mouse1.16943892
59OCT4_18555785_Chip-Seq_ESCs_Mouse1.16829022
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16592654
61SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14001231
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12240080
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.12176960
64FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11014300
65P300_18555785_Chip-Seq_ESCs_Mouse1.10439877
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.10194743
67SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09717362
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08774581
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07996805
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07996805
71KLF4_18555785_Chip-Seq_ESCs_Mouse1.05785112
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05150567
73RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04869956
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04329373
75OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03424750
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02983752
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02916156
78RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02781886
79SPI1_26923725_Chip-Seq_HPCs_Mouse1.01726807
80CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01464707
81ESET_19884257_ChIP-Seq_ESCs_Mouse1.01403613
82ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00407821
83GF1B_26923725_Chip-Seq_HPCs_Mouse0.98350649
84ERG_20517297_ChIP-Seq_VCAP_Human0.97807597
85SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96643772
86SOX9_26525672_Chip-Seq_HEART_Mouse0.96576836
87STAT3_18555785_Chip-Seq_ESCs_Mouse0.95699318
88SOX2_18555785_Chip-Seq_ESCs_Mouse0.94750054
89LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92964259
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92711596
91PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91706306
92PU1_27457419_Chip-Seq_LIVER_Mouse0.90803952
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90678248
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.89667902
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89363445
96MYC_27129775_Chip-Seq_CORNEA_Mouse0.88400473
97CTCF_18555785_Chip-Seq_ESCs_Mouse0.87898534
98RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87423433
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87184441
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86079473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08805726
2MP0001929_abnormal_gametogenesis5.65094701
3MP0008877_abnormal_DNA_methylation4.45067017
4MP0002210_abnormal_sex_determination3.47514258
5MP0002161_abnormal_fertility/fecundity3.29554384
6MP0001145_abnormal_male_reproductive2.96393026
7MP0000653_abnormal_sex_gland2.59089297
8MP0002653_abnormal_ependyma_morphology2.37494026
9MP0005670_abnormal_white_adipose2.36778918
10MP0005410_abnormal_fertilization16.3772114
11MP0005623_abnormal_meninges_morphology1.72976213
12MP0002160_abnormal_reproductive_system1.55530883
13MP0003646_muscle_fatigue1.51598228
14MP0002282_abnormal_trachea_morphology1.39296313
15MP0001765_abnormal_ion_homeostasis1.18974879
16MP0009046_muscle_twitch1.15337860
17MP0005647_abnormal_sex_gland1.14648381
18MP0004233_abnormal_muscle_weight1.13859787
19MP0008058_abnormal_DNA_repair1.07106820
20MP0008057_abnormal_DNA_replication0.98136913
21MP0001984_abnormal_olfaction0.93587841
22MP0003011_delayed_dark_adaptation0.86168417
23MP0005389_reproductive_system_phenotype0.80147527
24MP0002234_abnormal_pharynx_morphology0.80020129
25MP0008995_early_reproductive_senescence0.70480880
26MP0000569_abnormal_digit_pigmentation0.63515167
27MP0005636_abnormal_mineral_homeostasis0.63220650
28MP0004036_abnormal_muscle_relaxation0.59577052
29MP0010094_abnormal_chromosome_stability0.58475681
30MP0002139_abnormal_hepatobiliary_system0.53420264
31MP0003950_abnormal_plasma_membrane0.52847725
32MP0005253_abnormal_eye_physiology0.52107886
33MP0004134_abnormal_chest_morphology0.50911535
34MP0001324_abnormal_eye_pigmentation0.49343782
35MP0003329_amyloid_beta_deposits0.48902071
36MP0003699_abnormal_female_reproductive0.48706614
37MP0003786_premature_aging0.48024675
38MP0005551_abnormal_eye_electrophysiolog0.47988478
39MP0002736_abnormal_nociception_after0.44337947
40MP0004019_abnormal_vitamin_homeostasis0.44172752
41MP0003115_abnormal_respiratory_system0.43927032
42MP0005377_hearing/vestibular/ear_phenot0.43663410
43MP0003878_abnormal_ear_physiology0.43663410
44MP0005666_abnormal_adipose_tissue0.41816955
45MP0001545_abnormal_hematopoietic_system0.40604056
46MP0005397_hematopoietic_system_phenotyp0.40604056
47MP0002102_abnormal_ear_morphology0.39304909
48MP0004133_heterotaxia0.38308018
49MP0006072_abnormal_retinal_apoptosis0.38261789
50MP0003633_abnormal_nervous_system0.37154728
51MP0008007_abnormal_cellular_replicative0.37136641
52MP0002269_muscular_atrophy0.35912919
53MP0001764_abnormal_homeostasis0.35032448
54MP0001119_abnormal_female_reproductive0.34765507
55MP0000358_abnormal_cell_content/0.34373662
56MP0002928_abnormal_bile_duct0.33298169
57MP0005391_vision/eye_phenotype0.31675866
58MP0001293_anophthalmia0.30020706
59MP0006036_abnormal_mitochondrial_physio0.28948605
60MP0010307_abnormal_tumor_latency0.28145849
61MP0004084_abnormal_cardiac_muscle0.27460207
62MP0003631_nervous_system_phenotype0.27322398
63MP0000604_amyloidosis0.25218022
64MP0009115_abnormal_fat_cell0.24001440
65MP0001968_abnormal_touch/_nociception0.23641233
66MP0002971_abnormal_brown_adipose0.23260642
67MP0004811_abnormal_neuron_physiology0.22747776
68MP0000534_abnormal_ureter_morphology0.22232290
69MP0003861_abnormal_nervous_system0.22089382
70MP0009278_abnormal_bone_marrow0.21633864
71MP0002152_abnormal_brain_morphology0.21422875
72MP0009250_abnormal_appendicular_skeleto0.20536372
73MP0004808_abnormal_hematopoietic_stem0.20449602
74MP0002169_no_abnormal_phenotype0.20389259
75MP0001730_embryonic_growth_arrest0.20323062
76MP0002873_normal_phenotype0.20298189
77MP0004043_abnormal_pH_regulation0.19879486
78MP0000751_myopathy0.19847925
79MP0001727_abnormal_embryo_implantation0.18964124
80MP0004145_abnormal_muscle_electrophysio0.18265190
81MP0002295_abnormal_pulmonary_circulatio0.17288865
82MP0005503_abnormal_tendon_morphology0.17152960
83MP0000462_abnormal_digestive_system0.16810121
84MP0002909_abnormal_adrenal_gland0.15930632
85MP0008875_abnormal_xenobiotic_pharmacok0.15112110
86MP0005195_abnormal_posterior_eye0.15061512
87MP0000432_abnormal_head_morphology0.14598624
88MP0002229_neurodegeneration0.14081546
89MP0003111_abnormal_nucleus_morphology0.14047616
90MP0005319_abnormal_enzyme/_coenzyme0.13987743
91MP0003948_abnormal_gas_homeostasis0.13526050
92MP0003942_abnormal_urinary_system0.13472171
93MP0000001_mammalian_phenotype0.12908863
94MP0002109_abnormal_limb_morphology0.12836215
95MP0005365_abnormal_bile_salt0.11813997
96MP0000313_abnormal_cell_death0.11742831
97MP0003879_abnormal_hair_cell0.11449003
98MP0000427_abnormal_hair_cycle0.11084304
99MP0009697_abnormal_copulation0.11035989
100MP0002084_abnormal_developmental_patter0.10927038

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.44586672
2Abnormal respiratory epithelium morphology (HP:0012253)9.44586672
3Abnormal ciliary motility (HP:0012262)8.34521568
4Chronic bronchitis (HP:0004469)8.07020361
5Rhinitis (HP:0012384)7.80899699
6Infertility (HP:0000789)6.48664901
7Nasal polyposis (HP:0100582)6.23672596
8Abnormality of the nasal mucosa (HP:0000433)5.12811519
9Bronchitis (HP:0012387)4.61758568
10Bronchiectasis (HP:0002110)4.43014626
11Male infertility (HP:0003251)4.18555226
12Recurrent sinusitis (HP:0011108)3.98622660
13Nephronophthisis (HP:0000090)3.80754333
14Recurrent otitis media (HP:0000403)3.35897219
15Abnormal spermatogenesis (HP:0008669)3.19264897
16Abnormality of the renal medulla (HP:0100957)2.85924986
17Medial flaring of the eyebrow (HP:0010747)2.56965958
18Molar tooth sign on MRI (HP:0002419)2.53632056
19Abnormality of midbrain morphology (HP:0002418)2.53632056
20Tubulointerstitial nephritis (HP:0001970)2.51317009
21Tubular atrophy (HP:0000092)2.37447583
22Recurrent bronchitis (HP:0002837)2.31584039
23Tubulointerstitial abnormality (HP:0001969)2.22572884
24Gonadotropin excess (HP:0000837)2.11219693
25Azoospermia (HP:0000027)2.02705009
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.0970524
27Dynein arm defect of respiratory motile cilia (HP:0012255)13.8639584
28Absent/shortened dynein arms (HP:0200106)13.8639584
29Abnormal respiratory motile cilium physiology (HP:0012261)10.1043674
30Fibular hypoplasia (HP:0003038)1.87255852
31Tubulointerstitial fibrosis (HP:0005576)1.84861597
32Impulsivity (HP:0100710)1.82350537
33Dyschromatopsia (HP:0007641)1.80204405
34Abnormality of the dental root (HP:0006486)1.69358511
35Taurodontia (HP:0000679)1.69358511
36Abnormality of permanent molar morphology (HP:0011071)1.69358511
37Decreased central vision (HP:0007663)1.69061535
38Stage 5 chronic kidney disease (HP:0003774)1.69033982
39Postaxial foot polydactyly (HP:0001830)1.68381008
40Abnormality of the renal cortex (HP:0011035)1.68163971
41Polydipsia (HP:0001959)1.63564037
42Abnormal drinking behavior (HP:0030082)1.63564037
43Abnormality of renal excretion (HP:0011036)1.61629403
44Congenital hepatic fibrosis (HP:0002612)1.59898538
45Cholecystitis (HP:0001082)1.59424137
46Abnormal gallbladder physiology (HP:0012438)1.59424137
47Abnormality of molar morphology (HP:0011070)1.57493919
48Abnormality of molar (HP:0011077)1.57493919
49Abnormality of the dental pulp (HP:0006479)1.57172433
50Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54993727
51Chronic sinusitis (HP:0011109)1.53473484
52Gait imbalance (HP:0002141)1.51436859
53Abnormality of dentin (HP:0010299)1.51217271
54Congenital primary aphakia (HP:0007707)1.50376366
55Absent frontal sinuses (HP:0002688)1.49628237
56Microglossia (HP:0000171)1.49608881
57Short ribs (HP:0000773)1.48227850
58Abnormality of the lower motor neuron (HP:0002366)1.44797348
59Aplasia/Hypoplasia of the lens (HP:0008063)1.41616691
60Absent epiphyses (HP:0010577)1.41032057
61Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.41032057
62Pancreatic fibrosis (HP:0100732)1.40625007
63Oculomotor apraxia (HP:0000657)1.39863639
64Postaxial hand polydactyly (HP:0001162)1.39390793
65Choroideremia (HP:0001139)1.38465761
66Vascular calcification (HP:0004934)1.35459415
67Cystic liver disease (HP:0006706)1.33435524
68Spastic tetraparesis (HP:0001285)1.32830468
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.30832408
70Renal dysplasia (HP:0000110)1.29624676
71Facial cleft (HP:0002006)1.28161451
72J-shaped sella turcica (HP:0002680)1.27438809
73Amyotrophic lateral sclerosis (HP:0007354)1.25644371
74Nephrogenic diabetes insipidus (HP:0009806)1.24967189
75Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24357642
76Heterotopia (HP:0002282)1.23370906
77Asymmetric septal hypertrophy (HP:0001670)1.22404432
78Cardiovascular calcification (HP:0011915)1.21560293
79Genital tract atresia (HP:0001827)1.19886556
80Abnormal urine output (HP:0012590)1.19621731
81Short femoral neck (HP:0100864)1.19484014
82Hemorrhage of the eye (HP:0011885)1.18262072
83Aplasia/Hypoplasia of the fibula (HP:0006492)1.17927339
84Deformed sella turcica (HP:0002681)1.16542898
85Bell-shaped thorax (HP:0001591)1.16441868
86Bile duct proliferation (HP:0001408)1.16432553
87Abnormal biliary tract physiology (HP:0012439)1.16432553
88Neurofibrillary tangles (HP:0002185)1.16258910
89Abnormality of saccadic eye movements (HP:0000570)1.15568726
90Vaginal atresia (HP:0000148)1.15025415
91Median cleft lip (HP:0000161)1.13306113
92True hermaphroditism (HP:0010459)1.13148914
93Congenital malformation of the right heart (HP:0011723)1.13004236
94Double outlet right ventricle (HP:0001719)1.13004236
95Bundle branch block (HP:0011710)1.10472048
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.10406159
97Breast carcinoma (HP:0003002)1.09166411
98Constricted visual fields (HP:0001133)1.08841044
99Poor coordination (HP:0002370)1.08040108
100Exercise-induced myalgia (HP:0003738)1.06613458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.15946928
2PDK49.15946928
3PDK25.93188082
4TESK14.85063869
5PRKD34.00062849
6ICK3.28081594
7PTK2B2.27052145
8STK392.22676655
9WNK42.19213980
10PNCK1.86819025
11STK381.52199724
12NEK21.50235728
13PDK11.20096605
14DYRK1B1.10002675
15IRAK10.86895723
16TYRO30.84373508
17DYRK30.82643381
18WNK10.79354802
19PASK0.75075414
20MAPK150.68347360
21TESK20.65922213
22PDPK10.64464038
23CCNB10.62599688
24STK30.61960780
25TTK0.61267570
26STK38L0.59387039
27LMTK20.59087972
28EEF2K0.58708862
29PINK10.57462105
30CHEK20.52420860
31MAP2K60.51233129
32RIPK40.46220220
33CAMK1G0.38989121
34IRAK20.38511913
35CHEK10.36704873
36WEE10.35872774
37NTRK20.35131967
38MAPKAPK50.33628878
39MAP3K100.32492798
40MUSK0.31799150
41PRKCG0.31298842
42PAK10.30599935
43CAMKK10.29553949
44BRSK20.27827973
45PRKG20.27485131
46ATM0.25626487
47ATR0.22864455
48PLK40.22155164
49MARK20.19726306
50MARK30.18202443
51CDK150.17436257
52NEK60.17367215
53PLK10.17088006
54PAK20.17067597
55PRKAA10.16442967
56RPS6KB10.14859037
57CDK180.14757805
58PKN10.14509896
59PRKG10.13367250
60CDK11A0.12816729
61MTOR0.12323370
62STK100.11802508
63PRKCQ0.11385784
64CDC70.11237083
65BRAF0.11184942
66PRKACG0.11023266
67PRKCZ0.10946318
68CDK140.10564050
69WNK30.07818621
70BRSK10.07626857
71CSNK2A10.07371425
72MAP3K40.07271002
73DDR20.07164368
74CSF1R0.06831744
75CAMK2A0.04896750
76PAK40.04614769
77RPS6KA10.03942022
78STK110.03240895
79CSNK1D0.02934574
80MAPK80.02624542
81CSNK2A20.02088304
82CDK10.01987387
83MAP2K70.01800426
84PRKCA0.01750291
85GSK3B0.01570613
86PRKCD0.01199898
87EGFR0.00891388
88PRKACA0.00549639
89CDK20.00073373
90RPS6KA3-0.0278862
91PRKDC-0.0223471
92MINK1-0.0194027
93MARK1-0.0191972
94MET-0.0165758
95PDGFRB-0.0136653
96MAP3K5-0.0105077
97AURKA-0.0103768
98OXSR1-0.0103468
99PRKCB-0.0045970
100PAK6-0.0040432

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.37367434
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.41144764
3Pyruvate metabolism_Homo sapiens_hsa006204.17440432
4Fatty acid biosynthesis_Homo sapiens_hsa000613.91447805
5Propanoate metabolism_Homo sapiens_hsa006403.49374526
6Glucagon signaling pathway_Homo sapiens_hsa049222.90063311
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.59083971
8Linoleic acid metabolism_Homo sapiens_hsa005912.54534695
9Pentose phosphate pathway_Homo sapiens_hsa000302.50968164
10Basal transcription factors_Homo sapiens_hsa030222.41752796
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.29441626
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.18423643
13Selenocompound metabolism_Homo sapiens_hsa004501.96765510
14PPAR signaling pathway_Homo sapiens_hsa033201.89638679
15Glycerolipid metabolism_Homo sapiens_hsa005611.88923483
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.78753883
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.77724574
18Oocyte meiosis_Homo sapiens_hsa041141.76941895
19Amphetamine addiction_Homo sapiens_hsa050311.70474398
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.62310876
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.62007511
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52653370
23Carbon metabolism_Homo sapiens_hsa012001.44819721
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44629375
25Renin secretion_Homo sapiens_hsa049241.42235477
26Fanconi anemia pathway_Homo sapiens_hsa034601.37903519
27Mineral absorption_Homo sapiens_hsa049781.36437124
28Cardiac muscle contraction_Homo sapiens_hsa042601.26443897
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.25774777
30Fructose and mannose metabolism_Homo sapiens_hsa000511.23274021
31Ether lipid metabolism_Homo sapiens_hsa005651.22070694
32Fat digestion and absorption_Homo sapiens_hsa049751.13999453
33Fatty acid degradation_Homo sapiens_hsa000711.12018460
34Fatty acid metabolism_Homo sapiens_hsa012121.11513739
35Biosynthesis of amino acids_Homo sapiens_hsa012301.10902007
36Huntingtons disease_Homo sapiens_hsa050161.10641725
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07937756
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02604203
39Purine metabolism_Homo sapiens_hsa002301.02514004
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99867892
41Dorso-ventral axis formation_Homo sapiens_hsa043200.99331521
42Collecting duct acid secretion_Homo sapiens_hsa049660.98569635
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93499010
44Glutathione metabolism_Homo sapiens_hsa004800.90886099
45Long-term potentiation_Homo sapiens_hsa047200.85913604
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82017900
47Chemical carcinogenesis_Homo sapiens_hsa052040.79226410
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75571278
49Insulin secretion_Homo sapiens_hsa049110.74924094
50Renin-angiotensin system_Homo sapiens_hsa046140.74305106
51mRNA surveillance pathway_Homo sapiens_hsa030150.71828786
52Antigen processing and presentation_Homo sapiens_hsa046120.68772133
53RNA transport_Homo sapiens_hsa030130.64110426
54Thyroid hormone synthesis_Homo sapiens_hsa049180.63441328
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61556608
56Estrogen signaling pathway_Homo sapiens_hsa049150.58995556
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58364524
58Calcium signaling pathway_Homo sapiens_hsa040200.58247140
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57700339
60Bile secretion_Homo sapiens_hsa049760.56560647
61Sulfur metabolism_Homo sapiens_hsa009200.55844997
62Arachidonic acid metabolism_Homo sapiens_hsa005900.55393481
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.52161087
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51290795
65Protein digestion and absorption_Homo sapiens_hsa049740.50662474
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.50010642
67Hedgehog signaling pathway_Homo sapiens_hsa043400.46158585
68VEGF signaling pathway_Homo sapiens_hsa043700.44910045
69Pancreatic secretion_Homo sapiens_hsa049720.44730508
70Salivary secretion_Homo sapiens_hsa049700.43037877
71Synaptic vesicle cycle_Homo sapiens_hsa047210.42348829
72Metabolic pathways_Homo sapiens_hsa011000.41803039
73Inositol phosphate metabolism_Homo sapiens_hsa005620.39062460
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37993312
75AMPK signaling pathway_Homo sapiens_hsa041520.37727009
76ABC transporters_Homo sapiens_hsa020100.36299880
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.35743503
78Systemic lupus erythematosus_Homo sapiens_hsa053220.35125698
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34915405
80Gastric acid secretion_Homo sapiens_hsa049710.32359840
81cAMP signaling pathway_Homo sapiens_hsa040240.32345713
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31061050
83Endocytosis_Homo sapiens_hsa041440.30030402
84Cocaine addiction_Homo sapiens_hsa050300.29792971
85Olfactory transduction_Homo sapiens_hsa047400.28672272
86Circadian entrainment_Homo sapiens_hsa047130.26957065
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25680167
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.25554468
89B cell receptor signaling pathway_Homo sapiens_hsa046620.23659814
90Taste transduction_Homo sapiens_hsa047420.23626485
91Legionellosis_Homo sapiens_hsa051340.22152858
92Wnt signaling pathway_Homo sapiens_hsa043100.19011012
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18555446
94Glutamatergic synapse_Homo sapiens_hsa047240.18232626
95N-Glycan biosynthesis_Homo sapiens_hsa005100.15618946
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15546655
97Pyrimidine metabolism_Homo sapiens_hsa002400.15503149
98Alcoholism_Homo sapiens_hsa050340.13847951
99Retinol metabolism_Homo sapiens_hsa008300.08905412
100Dopaminergic synapse_Homo sapiens_hsa047280.07262835

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