TEX38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.86090174
2multicellular organism reproduction (GO:0032504)9.85405108
3spermatid development (GO:0007286)9.83391707
4axonemal dynein complex assembly (GO:0070286)9.18737062
5plasma membrane fusion (GO:0045026)9.13696370
6epithelial cilium movement (GO:0003351)9.09470040
7motile cilium assembly (GO:0044458)8.93997275
8regulation of cilium movement (GO:0003352)8.77483740
9reproduction (GO:0000003)8.58727908
10cilium or flagellum-dependent cell motility (GO:0001539)8.15611004
11response to pheromone (GO:0019236)8.07095602
12negative regulation of inclusion body assembly (GO:0090084)7.80359784
13piRNA metabolic process (GO:0034587)7.36707084
14rRNA methylation (GO:0031167)7.32018144
15cilium movement (GO:0003341)7.30357416
16protein targeting to Golgi (GO:0000042)7.16377889
17synaptonemal complex organization (GO:0070193)7.10615158
18sperm capacitation (GO:0048240)7.07257136
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.98291178
20establishment of protein localization to Golgi (GO:0072600)6.86360103
21spermatogenesis (GO:0007283)6.83486455
22synaptonemal complex assembly (GO:0007130)6.81601829
23male gamete generation (GO:0048232)6.80759332
24single fertilization (GO:0007338)6.78832540
25organic cation transport (GO:0015695)6.77386850
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.74632957
27retrograde transport, vesicle recycling within Golgi (GO:0000301)6.72164087
28phosphatidylethanolamine metabolic process (GO:0046337)6.65682574
29male meiosis (GO:0007140)6.57191142
30microtubule depolymerization (GO:0007019)6.45246935
31regulation of inclusion body assembly (GO:0090083)6.28837669
32gamete generation (GO:0007276)6.23809826
33rRNA modification (GO:0000154)6.14706341
34fertilization (GO:0009566)5.97048543
35calcium ion-dependent exocytosis (GO:0017156)5.65190899
36regulation of microtubule-based movement (GO:0060632)5.59134064
37chromosome condensation (GO:0030261)5.56948418
38germ cell development (GO:0007281)5.49587225
39cellular process involved in reproduction in multicellular organism (GO:0022412)5.39940266
40spermatid nucleus differentiation (GO:0007289)5.35431683
41protein localization to Golgi apparatus (GO:0034067)5.30647891
42cellular ketone body metabolic process (GO:0046950)5.26893395
43centriole replication (GO:0007099)5.26443392
44DNA packaging (GO:0006323)5.25461834
45ventricular system development (GO:0021591)4.95812828
46male meiosis I (GO:0007141)4.94953903
47multicellular organismal reproductive process (GO:0048609)4.94344330
48glycerol ether metabolic process (GO:0006662)4.80675594
49centriole assembly (GO:0098534)4.77930072
50regulation of Rab GTPase activity (GO:0032313)4.72691518
51positive regulation of Rab GTPase activity (GO:0032851)4.72691518
52microtubule severing (GO:0051013)4.72169404
53cell recognition (GO:0008037)4.68144302
54DNA methylation involved in gamete generation (GO:0043046)4.64842425
55ketone body metabolic process (GO:1902224)4.63786953
56seminiferous tubule development (GO:0072520)4.59107465
57chromosome organization involved in meiosis (GO:0070192)4.42739197
58ether metabolic process (GO:0018904)4.41994711
59regulation of transcription involved in cell fate commitment (GO:0060850)4.36345663
60left/right pattern formation (GO:0060972)4.35798509
61chaperone-mediated protein complex assembly (GO:0051131)4.20578483
62meiotic nuclear division (GO:0007126)4.19985810
63sexual reproduction (GO:0019953)4.15357709
64meiosis I (GO:0007127)4.09877118
65multicellular organismal development (GO:0007275)3.93977386
66protein refolding (GO:0042026)3.93802334
67sequestering of actin monomers (GO:0042989)3.91943659
68polyol catabolic process (GO:0046174)3.74366403
69peptidyl-threonine dephosphorylation (GO:0035970)3.73946960
70response to acidic pH (GO:0010447)3.70621662
71protein polyglutamylation (GO:0018095)3.68878194
72single strand break repair (GO:0000012)3.66739404
73regulation of centriole replication (GO:0046599)3.65633114
74regulation of somitogenesis (GO:0014807)3.61602688
75coenzyme catabolic process (GO:0009109)3.60109258
76negative regulation of Rho protein signal transduction (GO:0035024)3.51708952
77carnitine transport (GO:0015879)3.49530872
78amino-acid betaine transport (GO:0015838)3.49530872
79regulation of spindle checkpoint (GO:0090231)3.43571816
80nonmotile primary cilium assembly (GO:0035058)3.40437789
81genitalia morphogenesis (GO:0035112)3.39557192
82protein K11-linked deubiquitination (GO:0035871)3.34107074
83carnitine transmembrane transport (GO:1902603)3.34070209
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30380491
85multicellular organismal movement (GO:0050879)3.28763533
86musculoskeletal movement (GO:0050881)3.28763533
87regulation of interleukin-13 production (GO:0032656)3.27721824
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.26470997
89microtubule polymerization or depolymerization (GO:0031109)3.25432285
90left/right axis specification (GO:0070986)3.25024488
91meiotic cell cycle (GO:0051321)3.24518250
92histone H3-K9 demethylation (GO:0033169)3.23447548
93nucleus organization (GO:0006997)3.22920492
94glycolytic process (GO:0006096)3.14241467
95cerebral cortex neuron differentiation (GO:0021895)3.13595590
96regulation of phosphoprotein phosphatase activity (GO:0043666)3.06557005
97regulation of protein polyubiquitination (GO:1902914)3.05767718
98mitochondrion degradation (GO:0000422)3.04916356
99mitotic sister chromatid cohesion (GO:0007064)2.99814180
100membrane protein intracellular domain proteolysis (GO:0031293)2.96742554
101microtubule nucleation (GO:0007020)2.96736506
102cellular response to pH (GO:0071467)2.96482780
103interferon-gamma secretion (GO:0072643)2.96230169
104cranial nerve morphogenesis (GO:0021602)2.96010127
105regulation of T-helper 2 cell differentiation (GO:0045628)2.95297422
106polyamine biosynthetic process (GO:0006596)2.93298892
107negative regulation of gene expression, epigenetic (GO:0045814)2.91971130
108mitochondrial fission (GO:0000266)2.83378246
109histone exchange (GO:0043486)2.83190059
110axoneme assembly (GO:0035082)2.82621035
111vesicle transport along microtubule (GO:0047496)2.81855440
112NAD biosynthetic process (GO:0009435)2.81776511
113alditol metabolic process (GO:0019400)2.80353044
114RNA destabilization (GO:0050779)2.77910956
115protein-DNA complex disassembly (GO:0032986)2.76346945
116nucleosome disassembly (GO:0006337)2.76346945
117nucleoside diphosphate phosphorylation (GO:0006165)2.76018134
118monoubiquitinated protein deubiquitination (GO:0035520)2.75473460
119meiotic cell cycle process (GO:1903046)2.74680101
120chromatin silencing (GO:0006342)2.74229687
121protein localization to cilium (GO:0061512)2.73408421
122RNA localization (GO:0006403)2.73303042
123tooth mineralization (GO:0034505)2.72440063
124negative regulation of histone methylation (GO:0031061)2.72138760
125negative regulation of DNA repair (GO:0045738)2.71706758
126homeostasis of number of cells within a tissue (GO:0048873)2.71356329
127positive regulation of macrophage activation (GO:0043032)2.71219913
128intra-Golgi vesicle-mediated transport (GO:0006891)2.70244401
129microtubule-based movement (GO:0007018)2.66703449
130peptidyl-glutamic acid modification (GO:0018200)2.64210318
131regulation of cilium assembly (GO:1902017)2.61582613
132positive regulation of glycolytic process (GO:0045821)2.60612273
133protein K48-linked deubiquitination (GO:0071108)2.56402910
134cellular component assembly involved in morphogenesis (GO:0010927)2.51381958
135cilium organization (GO:0044782)2.46818378
136quaternary ammonium group transport (GO:0015697)2.45913445
137lactate metabolic process (GO:0006089)2.43612085
138negative regulation of organelle assembly (GO:1902116)2.42826087
139sperm motility (GO:0030317)13.8526111
140acrosome reaction (GO:0007340)12.2776346
141fusion of sperm to egg plasma membrane (GO:0007342)12.0499171
142cell wall macromolecule catabolic process (GO:0016998)11.5255888
143cell wall macromolecule metabolic process (GO:0044036)11.5255888
144acrosome assembly (GO:0001675)11.4969788
145sperm-egg recognition (GO:0035036)11.0057828
146binding of sperm to zona pellucida (GO:0007339)10.1040677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.17871611
2EZH2_22144423_ChIP-Seq_EOC_Human5.12711373
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.00237679
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.68405053
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12670609
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.83879420
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80125427
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68914910
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.40613773
10VDR_22108803_ChIP-Seq_LS180_Human2.31921060
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18011347
12DROSHA_22980978_ChIP-Seq_HELA_Human2.12382819
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11176422
14FUS_26573619_Chip-Seq_HEK293_Human2.09250525
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.01907211
16ZNF274_21170338_ChIP-Seq_K562_Hela2.00765324
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.99646588
18ERA_21632823_ChIP-Seq_H3396_Human1.91298761
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91236786
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89980946
21FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82470209
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78160171
23RAC3_21632823_ChIP-Seq_H3396_Human1.76197362
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.72796133
25SOX2_22085726_ChIP-Seq_NPCs_Mouse1.64914582
26ER_23166858_ChIP-Seq_MCF-7_Human1.64513088
27MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59432057
28FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59427828
29OCT4_20526341_ChIP-Seq_ESCs_Human1.59111269
30GATA3_21867929_ChIP-Seq_CD8_Mouse1.55613396
31STAT1_17558387_ChIP-Seq_HELA_Human1.55589833
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55194897
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.54934600
34AUTS2_25519132_ChIP-Seq_293T-REX_Human1.54841398
35PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.53414325
36TAF2_19829295_ChIP-Seq_ESCs_Human1.51039201
37WDR5_24793694_ChIP-Seq_LNCAP_Human1.50863563
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50460387
39GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49609880
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47711229
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46316810
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45964450
43AR_25329375_ChIP-Seq_VCAP_Human1.45933449
44MYC_19829295_ChIP-Seq_ESCs_Human1.45672266
45P68_20966046_ChIP-Seq_HELA_Human1.43774582
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42774938
47SMAD4_21741376_ChIP-Seq_EPCs_Human1.41860532
48P53_21459846_ChIP-Seq_SAOS-2_Human1.41492666
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39981851
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.39739304
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.39725439
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.37468274
53TP63_22573176_ChIP-Seq_HFKS_Human1.36824324
54LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35473188
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.35431811
56REST_21632747_ChIP-Seq_MESCs_Mouse1.35071267
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33873188
58BCOR_27268052_Chip-Seq_Bcells_Human1.33839654
59RAD21_21589869_ChIP-Seq_MESCs_Mouse1.30820936
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.28694234
61TAF15_26573619_Chip-Seq_HEK293_Human1.28166679
62GF1_26923725_Chip-Seq_HPCs_Mouse1.28089805
63P300_27268052_Chip-Seq_Bcells_Human1.27994636
64P300_19829295_ChIP-Seq_ESCs_Human1.27535429
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.25255385
66RBPJ_21746931_ChIP-Seq_IB4_Human1.24854734
67SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24438947
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.24320947
69ETV1_20927104_ChIP-Seq_GIST48_Human1.24040821
70JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.23831037
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23792154
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23767428
73CBP_20019798_ChIP-Seq_JUKART_Human1.23767428
74CBX2_22325352_ChIP-Seq_293T-Rex_Human1.23606315
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.23573091
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.23563766
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23064994
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22866573
79CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22836632
80SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.21697788
81MYC_27129775_Chip-Seq_CORNEA_Mouse1.21485201
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21413502
83SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21398705
84ERG_20517297_ChIP-Seq_VCAP_Human1.20933605
85P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20882902
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19926283
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19799851
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19004642
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.18883650
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18840553
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17802531
92SPI1_26923725_Chip-Seq_HPCs_Mouse1.17410961
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17156074
94LXR_22292898_ChIP-Seq_THP-1_Human1.16657645
95TP53_18474530_ChIP-ChIP_U2OS_Human1.16579813
96CEBPB_22108803_ChIP-Seq_LS180_Human1.16463513
97CTCF_27219007_Chip-Seq_Bcells_Human1.15781306
98AR_21572438_ChIP-Seq_LNCaP_Human1.15103464
99PHF8_20622854_ChIP-Seq_HELA_Human1.14880059
100KDM2B_26808549_Chip-Seq_REH_Human1.14402955
101CTCF_20526341_ChIP-Seq_ESCs_Human1.14208821
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12407655
103GATA1_19941827_ChIP-Seq_MEL86_Mouse1.12381954
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12234549
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.12060189
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11607514
107SMRT_27268052_Chip-Seq_Bcells_Human1.11467143
108RUNX2_22187159_ChIP-Seq_PCA_Human1.11188829
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10556167
110SMAD4_21799915_ChIP-Seq_A2780_Human1.10382937
111TBL1_22424771_ChIP-Seq_293T_Human1.10370263
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09453665
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08993577
114BCL6_27268052_Chip-Seq_Bcells_Human1.08800169
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.08352122
116GATA3_21867929_ChIP-Seq_TH1_Mouse1.08115514
117SA1_27219007_Chip-Seq_Bcells_Human1.07509963
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05552081
119NFYB_21822215_ChIP-Seq_K562_Human1.05337481
120STAT3_23295773_ChIP-Seq_U87_Human1.05278552
121RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04929566
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03497498
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02869389
124KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.02812257
125SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02784263
126TAL1_26923725_Chip-Seq_HPCs_Mouse1.02281721
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01910536
128SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99871327
129NANOG_19829295_ChIP-Seq_ESCs_Human0.99863110
130SOX2_19829295_ChIP-Seq_ESCs_Human0.99863110
131GATA6_21074721_ChIP-Seq_CACO-2_Human0.98985729
132KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98781809
133TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.98679203
134SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98486383
135SOX11_22085726_ChIP-Seq_ESNs_Mouse0.98299450
136PHF8_20622853_ChIP-Seq_HELA_Human0.98157668
137SMC4_20622854_ChIP-Seq_HELA_Human0.98121917
138OCT4_19829295_ChIP-Seq_ESCs_Human0.97679121
139EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96607205
140PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96478251
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96205636
142NANOG_20526341_ChIP-Seq_ESCs_Human0.96067186
143SOX2_21211035_ChIP-Seq_LN229_Human0.96004473
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.95931608
145NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94599917
146RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93825536
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.93294660
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93165588
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92427600
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92414228
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92414228
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91522834
153LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91354268
154RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90609996
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90521911
156CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90453977
157FLI1_21867929_ChIP-Seq_CD8_Mouse0.90183407
158CBX2_27304074_Chip-Seq_ESCs_Mouse0.88901286
159SMAD3_21741376_ChIP-Seq_ESCs_Human0.87782542
160ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86872845
161ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86738224
162E2F1_20622854_ChIP-Seq_HELA_Human0.85436314
163CTCF_26484167_Chip-Seq_Bcells_Mouse0.85323126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.87418123
2MP0001929_abnormal_gametogenesis5.34329761
3MP0008877_abnormal_DNA_methylation3.65790564
4MP0002161_abnormal_fertility/fecundity3.25780411
5MP0002210_abnormal_sex_determination3.17795976
6MP0001348_abnormal_lacrimal_gland3.04286098
7MP0001145_abnormal_male_reproductive2.70410135
8MP0005670_abnormal_white_adipose2.70391497
9MP0002653_abnormal_ependyma_morphology2.54904439
10MP0005423_abnormal_somatic_nervous2.44303505
11MP0000678_abnormal_parathyroid_gland2.36496883
12MP0000653_abnormal_sex_gland2.33435259
13MP0003646_muscle_fatigue2.27398869
14MP0003718_maternal_effect2.00889112
15MP0005410_abnormal_fertilization15.9960418
16MP0002160_abnormal_reproductive_system1.91617790
17MP0001485_abnormal_pinna_reflex1.80516760
18MP0002822_catalepsy1.79652778
19MP0002132_abnormal_respiratory_system1.73010833
20MP0004233_abnormal_muscle_weight1.62760463
21MP0001984_abnormal_olfaction1.43136153
22MP0002249_abnormal_larynx_morphology1.40868779
23MP0004859_abnormal_synaptic_plasticity1.37798905
24MP0005083_abnormal_biliary_tract1.36889233
25MP0001486_abnormal_startle_reflex1.35672265
26MP0005379_endocrine/exocrine_gland_phen1.33007453
27MP0006292_abnormal_olfactory_placode1.30288415
28MP0004742_abnormal_vestibular_system1.29080538
29MP0008995_early_reproductive_senescence1.26285035
30MP0003787_abnormal_imprinting1.15423775
31MP0005310_abnormal_salivary_gland1.13634413
32MP0001963_abnormal_hearing_physiology1.12922654
33MP0002735_abnormal_chemical_nociception1.10561106
34MP0003329_amyloid_beta_deposits1.10390981
35MP0001905_abnormal_dopamine_level1.09822187
36MP0005623_abnormal_meninges_morphology1.09273220
37MP0001765_abnormal_ion_homeostasis1.07167641
38MP0000026_abnormal_inner_ear1.06715707
39MP0002234_abnormal_pharynx_morphology1.05772145
40MP0005647_abnormal_sex_gland1.03921435
41MP0002139_abnormal_hepatobiliary_system1.02109615
42MP0001968_abnormal_touch/_nociception1.00737283
43MP0005389_reproductive_system_phenotype0.94633576
44MP0005395_other_phenotype0.94445963
45MP0003115_abnormal_respiratory_system0.88931015
46MP0002557_abnormal_social/conspecific_i0.88737849
47MP0002269_muscular_atrophy0.88227485
48MP0002254_reproductive_system_inflammat0.87488800
49MP0001529_abnormal_vocalization0.87296540
50MP0002127_abnormal_cardiovascular_syste0.85079061
51MP0002138_abnormal_hepatobiliary_system0.79247336
52MP0002282_abnormal_trachea_morphology0.78979739
53MP0002272_abnormal_nervous_system0.76679063
54MP0002067_abnormal_sensory_capabilities0.74038567
55MP0004036_abnormal_muscle_relaxation0.73966769
56MP0005248_abnormal_Harderian_gland0.73185680
57MP0003878_abnormal_ear_physiology0.72439426
58MP0005377_hearing/vestibular/ear_phenot0.72439426
59MP0000534_abnormal_ureter_morphology0.70752450
60MP0000613_abnormal_salivary_gland0.70393912
61MP0002572_abnormal_emotion/affect_behav0.69975399
62MP0001270_distended_abdomen0.69876876
63MP0003786_premature_aging0.69562375
64MP0004085_abnormal_heartbeat0.68491041
65MP0003880_abnormal_central_pattern0.68247209
66MP0005451_abnormal_body_composition0.67244667
67MP0009046_muscle_twitch0.66259550
68MP0009745_abnormal_behavioral_response0.63430800
69MP0003635_abnormal_synaptic_transmissio0.63210472
70MP0002734_abnormal_mechanical_nocicepti0.63017385
71MP0003122_maternal_imprinting0.62282789
72MP0003879_abnormal_hair_cell0.61910382
73MP0010307_abnormal_tumor_latency0.61557290
74MP0003699_abnormal_female_reproductive0.60580126
75MP0004510_myositis0.58156783
76MP0002909_abnormal_adrenal_gland0.57879178
77MP0008007_abnormal_cellular_replicative0.57864504
78MP0000681_abnormal_thyroid_gland0.57486541
79MP0008058_abnormal_DNA_repair0.57364977
80MP0004145_abnormal_muscle_electrophysio0.57114533
81MP0002638_abnormal_pupillary_reflex0.56919455
82MP0001299_abnormal_eye_distance/0.56703698
83MP0008569_lethality_at_weaning0.56006418
84MP0001970_abnormal_pain_threshold0.55160547
85MP0010386_abnormal_urinary_bladder0.54871613
86MP0001501_abnormal_sleep_pattern0.53946934
87MP0005636_abnormal_mineral_homeostasis0.53816752
88MP0004484_altered_response_of0.53650814
89MP0003631_nervous_system_phenotype0.52699816
90MP0002697_abnormal_eye_size0.51772904
91MP0003936_abnormal_reproductive_system0.51393613
92MP0006036_abnormal_mitochondrial_physio0.49211734
93MP0000604_amyloidosis0.49114672
94MP0002733_abnormal_thermal_nociception0.48582017
95MP0004270_analgesia0.47912205
96MP0005666_abnormal_adipose_tissue0.47781114
97MP0000751_myopathy0.47449070
98MP0009053_abnormal_anal_canal0.46818511
99MP0003633_abnormal_nervous_system0.46718032
100MP0003119_abnormal_digestive_system0.46336761
101MP0001324_abnormal_eye_pigmentation0.45792795
102MP0001502_abnormal_circadian_rhythm0.44693994
103MP0000749_muscle_degeneration0.44382286
104MP0002106_abnormal_muscle_physiology0.44361156
105MP0004811_abnormal_neuron_physiology0.44171941
106MP0002102_abnormal_ear_morphology0.43471775
107MP0005535_abnormal_body_temperature0.43255390
108MP0001879_abnormal_lymphatic_vessel0.42260727
109MP0003942_abnormal_urinary_system0.41648287
110MP0000358_abnormal_cell_content/0.41384127
111MP0008961_abnormal_basal_metabolism0.40867656
112MP0005253_abnormal_eye_physiology0.40559436
113MP0002752_abnormal_somatic_nervous0.40050405
114MP0004043_abnormal_pH_regulation0.39486294
115MP0001440_abnormal_grooming_behavior0.39376771
116MP0004130_abnormal_muscle_cell0.38967384
117MP0010329_abnormal_lipoprotein_level0.38704556
118MP0005391_vision/eye_phenotype0.38408290
119MP0003861_abnormal_nervous_system0.36676822
120MP0001764_abnormal_homeostasis0.36669861
121MP0010094_abnormal_chromosome_stability0.36033089
122MP0004087_abnormal_muscle_fiber0.35255738
123MP0009115_abnormal_fat_cell0.35126506
124MP0002837_dystrophic_cardiac_calcinosis0.34820361
125MP0001293_anophthalmia0.34409070
126MP0001849_ear_inflammation0.33693001
127MP0002092_abnormal_eye_morphology0.32435729
128MP0002152_abnormal_brain_morphology0.32308246
129MP0002928_abnormal_bile_duct0.32057868
130MP0001919_abnormal_reproductive_system0.31382703
131MP0002229_neurodegeneration0.31360838
132MP0001730_embryonic_growth_arrest0.30622612
133MP0004808_abnormal_hematopoietic_stem0.30289987
134MP0003948_abnormal_gas_homeostasis0.29767323
135MP0004858_abnormal_nervous_system0.29163640
136MP0005195_abnormal_posterior_eye0.28937727
137MP0002877_abnormal_melanocyte_morpholog0.28838031
138MP0002169_no_abnormal_phenotype0.27559075
139MP0008789_abnormal_olfactory_epithelium0.27363127
140MP0010630_abnormal_cardiac_muscle0.27319178
141MP0002873_normal_phenotype0.27146518
142MP0001944_abnormal_pancreas_morphology0.27008986
143MP0005369_muscle_phenotype0.26711933
144MP0003011_delayed_dark_adaptation0.26289759
145MP0000759_abnormal_skeletal_muscle0.26231744
146MP0005394_taste/olfaction_phenotype0.26199565
147MP0005499_abnormal_olfactory_system0.26199565
148MP0002693_abnormal_pancreas_physiology0.25969930
149MP0000313_abnormal_cell_death0.25678297
150MP0000955_abnormal_spinal_cord0.25327610
151MP0005375_adipose_tissue_phenotype0.24437037
152MP0002009_preneoplasia0.23993637
153MP0000013_abnormal_adipose_tissue0.22025064
154MP0002971_abnormal_brown_adipose0.21050472
155MP0005551_abnormal_eye_electrophysiolog0.21032692
156MP0000049_abnormal_middle_ear0.20969691
157MP0006035_abnormal_mitochondrial_morpho0.20389244
158MP0003953_abnormal_hormone_level0.19817469
159MP0001545_abnormal_hematopoietic_system0.19778623
160MP0005397_hematopoietic_system_phenotyp0.19778623

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.89918367
2Abnormal respiratory motile cilium morphology (HP:0005938)8.89918367
3Abnormal respiratory motile cilium physiology (HP:0012261)8.87463962
4Severe visual impairment (HP:0001141)8.25919948
5Rhinitis (HP:0012384)7.54139477
6Chronic bronchitis (HP:0004469)7.23157218
7Infertility (HP:0000789)7.23109195
8Abnormal ciliary motility (HP:0012262)6.67984082
9Nasal polyposis (HP:0100582)6.55416160
10Abnormality of the nasal mucosa (HP:0000433)5.34447558
11Bony spicule pigmentary retinopathy (HP:0007737)5.16603329
12Male infertility (HP:0003251)5.11621459
13Abnormal rod and cone electroretinograms (HP:0008323)4.90965746
14Attenuation of retinal blood vessels (HP:0007843)4.89370830
15Chronic hepatic failure (HP:0100626)4.70287314
16Bronchitis (HP:0012387)4.54759181
17Bronchiectasis (HP:0002110)4.23662902
18Hyperkalemia (HP:0002153)4.21957714
19Abnormality of macular pigmentation (HP:0008002)4.11776479
20Resting tremor (HP:0002322)3.95621022
21Potter facies (HP:0002009)3.92307093
22Facial shape deformation (HP:0011334)3.92307093
23Nephronophthisis (HP:0000090)3.90646451
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.85110864
25Abnormal spermatogenesis (HP:0008669)3.63281972
26Recurrent otitis media (HP:0000403)3.32052446
27Hypoplasia of the thymus (HP:0000778)3.16745416
28Impulsivity (HP:0100710)3.15528718
29Aplasia/Hypoplasia of the sacrum (HP:0008517)3.15316177
30Hypoplastic ischia (HP:0003175)3.13422376
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.13388562
32Cone-rod dystrophy (HP:0000548)3.05026526
33Enlarged epiphyses (HP:0010580)3.00643810
34Recurrent sinusitis (HP:0011108)3.00448713
35Abnormality of the renal medulla (HP:0100957)2.88045546
36Abnormality of the ischium (HP:0003174)2.86857744
37Postural instability (HP:0002172)2.83451980
38Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.79187047
39Recurrent bronchitis (HP:0002837)2.75827156
40Abnormality of the costochondral junction (HP:0000919)2.63023698
41Tubular atrophy (HP:0000092)2.62871960
42Abnormality of midbrain morphology (HP:0002418)2.52505996
43Molar tooth sign on MRI (HP:0002419)2.52505996
44Atonic seizures (HP:0010819)2.52198865
45Abnormal gallbladder physiology (HP:0012438)2.50520871
46Cholecystitis (HP:0001082)2.50520871
47Widely patent fontanelles and sutures (HP:0004492)2.50124393
48Insulin-resistant diabetes mellitus (HP:0000831)2.49556907
49Amelogenesis imperfecta (HP:0000705)2.43830326
50Dyschromatopsia (HP:0007641)2.38991280
51Hypoalphalipoproteinemia (HP:0003233)2.38611009
52Abnormality of potassium homeostasis (HP:0011042)2.38120677
53Abnormality of the aortic arch (HP:0012303)2.36153327
54Progressive sensorineural hearing impairment (HP:0000408)2.34490709
55Gonadotropin excess (HP:0000837)2.34362009
56Renal Fanconi syndrome (HP:0001994)2.33198188
57Abnormality of dental color (HP:0011073)2.30163955
58Truncal obesity (HP:0001956)2.29674106
59Progressive cerebellar ataxia (HP:0002073)2.23874623
60Generalized aminoaciduria (HP:0002909)2.23409323
61Portal hypertension (HP:0001409)2.22249655
62Abnormality of the hepatic vasculature (HP:0006707)2.21694270
63Tubulointerstitial nephritis (HP:0001970)2.21159259
64Tubulointerstitial abnormality (HP:0001969)2.16446380
65Azoospermia (HP:0000027)2.11665070
66Exercise-induced myalgia (HP:0003738)2.10874163
67Unilateral renal agenesis (HP:0000122)2.09067127
68Hyperthyroidism (HP:0000836)2.07363367
69Renovascular hypertension (HP:0100817)2.07299247
70Congenital stationary night blindness (HP:0007642)2.06424111
71Myokymia (HP:0002411)2.05838943
72Congenital malformation of the right heart (HP:0011723)2.04720002
73Double outlet right ventricle (HP:0001719)2.04720002
74Pancreatic fibrosis (HP:0100732)2.03014265
75Choroideremia (HP:0001139)2.00305861
76Absent/shortened dynein arms (HP:0200106)13.0018504
77Dynein arm defect of respiratory motile cilia (HP:0012255)13.0018504
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5468267
79Bundle branch block (HP:0011710)1.96924729
80Tubulointerstitial fibrosis (HP:0005576)1.95746711
81Spastic tetraparesis (HP:0001285)1.95455648
82Scotoma (HP:0000575)1.95437238
83Optic nerve hypoplasia (HP:0000609)1.94166404
84Abnormality of the parathyroid morphology (HP:0011766)1.93566075
85Decreased central vision (HP:0007663)1.93028666
86Medial flaring of the eyebrow (HP:0010747)1.92344472
87Myoglobinuria (HP:0002913)1.91678988
88Abnormal drinking behavior (HP:0030082)1.89577897
89Polydipsia (HP:0001959)1.89577897
90Asymmetric septal hypertrophy (HP:0001670)1.87104281
91Menstrual irregularities (HP:0000858)1.86922522
92Abnormality of the pubic bones (HP:0003172)1.86773615
93Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82581288
94Osteomalacia (HP:0002749)1.80640931
95Epiphyseal dysplasia (HP:0002656)1.78512787
96Hypophosphatemic rickets (HP:0004912)1.77757142
97Abnormality of renal resorption (HP:0011038)1.77044075
98Tetany (HP:0001281)1.76946420
99Abnormal ventriculo-arterial connection (HP:0011563)1.76096501
100Transposition of the great arteries (HP:0001669)1.76096501
101Abnormal connection of the cardiac segments (HP:0011545)1.76096501
102Cerebellar dysplasia (HP:0007033)1.75045572
103Pendular nystagmus (HP:0012043)1.74154923
104Atelectasis (HP:0100750)1.73847245
105Occipital encephalocele (HP:0002085)1.73506142
106Recurrent pneumonia (HP:0006532)1.73449695
107Flattened epiphyses (HP:0003071)1.72638577
108Flat capital femoral epiphysis (HP:0003370)1.71179845
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70656250
110Abnormality of renal excretion (HP:0011036)1.69936913
111Exercise-induced muscle cramps (HP:0003710)1.67160337
112Hyporeflexia of lower limbs (HP:0002600)1.66640023
113Hemorrhage of the eye (HP:0011885)1.66527679
114Postaxial foot polydactyly (HP:0001830)1.65415088
115Aplasia/Hypoplasia of the macula (HP:0008059)1.62584111
116Difficulty climbing stairs (HP:0003551)1.62340309
117Aplasia/Hypoplasia of the lens (HP:0008063)1.59896800
118Rhabdomyolysis (HP:0003201)1.59421221
119Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.58903625
120Stage 5 chronic kidney disease (HP:0003774)1.57024136
121Abnormal urine output (HP:0012590)1.56005262
122Heterotopia (HP:0002282)1.54184883
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.53772755
124Neurofibrillary tangles (HP:0002185)1.49755740
125Congenital hepatic fibrosis (HP:0002612)1.48344481
126Abnormality of the dental root (HP:0006486)1.48050467
127Taurodontia (HP:0000679)1.48050467
128Abnormality of permanent molar morphology (HP:0011071)1.48050467
129Abnormality of the lower motor neuron (HP:0002366)1.47439445
130Zonular cataract (HP:0010920)1.47379293
131Abnormality of the renal cortex (HP:0011035)1.45750664
132Oculomotor apraxia (HP:0000657)1.44147254
133Fatigable weakness (HP:0003473)1.43054057
134Abnormality of the neuromuscular junction (HP:0003398)1.43054057
135Abnormality of the dental pulp (HP:0006479)1.41616130
136Easy fatigability (HP:0003388)1.41554868
137Renal dysplasia (HP:0000110)1.40826247
138Fibular hypoplasia (HP:0003038)1.39203043
139EMG: neuropathic changes (HP:0003445)1.37365380
140Constricted visual fields (HP:0001133)1.35520772
141Abnormality of molar (HP:0011077)1.31628959
142Abnormality of molar morphology (HP:0011070)1.31628959
143Polyuria (HP:0000103)1.31088544
144Generalized muscle weakness (HP:0003324)1.30706556
145Decreased motor nerve conduction velocity (HP:0003431)1.29643729
146Bell-shaped thorax (HP:0001591)1.29145006
147Absent epiphyses (HP:0010577)1.29132319
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.29132319
149Hemiparesis (HP:0001269)1.28488532
150Short ribs (HP:0000773)1.27540900
151Postaxial hand polydactyly (HP:0001162)1.27511226
152Cerebral inclusion bodies (HP:0100314)1.26179262
153Sensory axonal neuropathy (HP:0003390)1.26131797
154Abnormal biliary tract physiology (HP:0012439)1.25430545
155Bile duct proliferation (HP:0001408)1.25430545
156Abnormality of the sella turcica (HP:0002679)1.24428997
157Sclerocornea (HP:0000647)1.23506306
158Personality changes (HP:0000751)1.20353302
159Hypercholesterolemia (HP:0003124)1.19566842
160Deformed sella turcica (HP:0002681)1.19491724
161Glucose intolerance (HP:0000833)1.19483773
162Cystic liver disease (HP:0006706)1.18822546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.76679470
2PDK37.29831439
3PDK47.29831439
4TESK16.87517820
5PRKD35.39177006
6ICK4.82754678
7PDK24.59395818
8DDR23.98294046
9BRD43.00316278
10PLK22.81254465
11INSRR2.62505493
12WNK42.40619811
13MAP4K22.34094053
14PTK2B2.06535301
15PNCK2.04559072
16STK392.03771352
17DYRK1B2.02998865
18STK381.91814072
19NEK21.78395006
20MST1R1.47100878
21AKT31.43550096
22MAPK151.31048057
23NEK61.28690599
24MAP3K41.28329281
25PDK11.17432304
26CDK121.17035947
27CAMK1D1.15286106
28CDK71.12370526
29PINK11.08456012
30CAMK10.98437466
31WNK10.97922226
32DYRK30.95990295
33CDK190.92954400
34NTRK20.88153773
35MAP3K100.82100858
36PDPK10.80390595
37RPS6KA20.77012885
38TYRO30.76879358
39WNK30.73902048
40WEE10.73617057
41ROCK10.70195211
42MAP3K110.68409846
43MUSK0.67947946
44TESK20.65897932
45PRKG10.64742753
46MAP3K90.64295103
47BMPR1B0.63839213
48RPS6KL10.62510272
49RPS6KC10.62510272
50RPS6KA60.61414310
51KSR20.61330384
52EEF2K0.60676695
53PASK0.59339887
54CAMK40.59184626
55MAP3K60.58315545
56MAP2K60.58130620
57ZAK0.56772241
58MAP3K20.56576582
59MAP2K20.55391963
60IRAK10.55193940
61RIPK10.53787702
62PIM10.53730685
63PRPF4B0.53318932
64CCNB10.53281464
65LMTK20.52733234
66OXSR10.52214710
67RIPK40.50801552
68LATS20.48289784
69MAPK10.48262039
70TTK0.48223804
71FRK0.47756070
72SIK20.47641326
73CHEK20.47094540
74PRKG20.46668617
75TLK10.46135121
76STK30.45676587
77BRSK20.45041136
78STK38L0.45004244
79CDK10.42812747
80PRKAA10.42336813
81PRKCG0.42042436
82ARAF0.41567491
83SGK20.41235330
84TRIB30.40070342
85SGK10.37866172
86BRSK10.36254985
87MET0.35648235
88MARK30.35480077
89MAP2K70.34444553
90PAK10.32828197
91SGK2230.32452193
92SGK4940.32452193
93RPS6KB10.30757923
94CDK30.30239075
95STK40.29984132
96FLT30.29809190
97MTOR0.29343156
98FGFR30.29046284
99IRAK20.28602426
100CAMK1G0.27732499
101CDK40.26994909
102MAPK140.26324079
103MAPK130.25276063
104SGK30.25133542
105CHEK10.24861136
106LATS10.24375520
107CAMKK10.24141652
108MAP2K40.23727697
109MARK20.23686545
110TIE10.23495203
111PRKCB0.23287577
112MAPK110.23254515
113PRKCZ0.23092994
114MAP3K80.22920272
115PLK30.21917006
116PLK10.20874270
117ACVR1B0.19454081
118GRK70.18934138
119FER0.18751050
120PKN10.18358664
121PRKACB0.18137247
122BRAF0.17544686
123MAP3K10.17456435
124CAMK2A0.17287357
125JAK30.17023517
126TTN0.16805320
127GSK3A0.15786609
128PAK20.15411632
129UHMK10.15408971
130PIK3CG0.14041453
131PRKCQ0.13227831
132ATM0.13161491
133RPS6KA10.11685568
134CDK60.10733415
135EPHB10.10152676
136PRKACG0.10007108
137CSF1R0.09981932
138AURKA0.09692966
139CDK150.08598684
140YES10.08369978
141PAK40.07950049
142BUB10.07351328
143GSK3B0.06936904
144CDK180.06654618
145STK110.05905880
146CASK0.05713465
147MAPK80.05153996
148CDK140.04757168
149CSNK2A10.04523767
150CDK11A0.04427640
151PRKAA20.02139055
152PRKACA0.02100501
153ATR0.01589532
154PHKG20.01409532
155PHKG10.01409532
156CDK20.00866653
157SIK10.00167331
158PAK60.00122862
159RPS6KA3-0.0054187

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.21004467
2Fatty acid biosynthesis_Homo sapiens_hsa000614.44774613
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.08828202
4Vitamin B6 metabolism_Homo sapiens_hsa007503.57391124
5Olfactory transduction_Homo sapiens_hsa047403.46985991
6Pyruvate metabolism_Homo sapiens_hsa006203.19621337
7Butanoate metabolism_Homo sapiens_hsa006502.93705283
8Selenocompound metabolism_Homo sapiens_hsa004502.91696447
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.80671740
10Glucagon signaling pathway_Homo sapiens_hsa049222.71598082
11Linoleic acid metabolism_Homo sapiens_hsa005912.69825417
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.52739284
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.42194412
14Propanoate metabolism_Homo sapiens_hsa006402.39888713
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27747889
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.18881385
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15396856
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.14896236
19Basal transcription factors_Homo sapiens_hsa030221.89230780
20Phototransduction_Homo sapiens_hsa047441.87515082
21Phenylalanine metabolism_Homo sapiens_hsa003601.83500502
22Fructose and mannose metabolism_Homo sapiens_hsa000511.81201652
23Glycerolipid metabolism_Homo sapiens_hsa005611.76288193
24PPAR signaling pathway_Homo sapiens_hsa033201.75129221
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.72280335
26Fatty acid degradation_Homo sapiens_hsa000711.68991325
27Fatty acid metabolism_Homo sapiens_hsa012121.68297563
28Fat digestion and absorption_Homo sapiens_hsa049751.68279919
29Oocyte meiosis_Homo sapiens_hsa041141.59426489
30Nicotine addiction_Homo sapiens_hsa050331.56544403
31Amphetamine addiction_Homo sapiens_hsa050311.54922546
32Cardiac muscle contraction_Homo sapiens_hsa042601.52891385
33Pentose phosphate pathway_Homo sapiens_hsa000301.52558642
34Carbon metabolism_Homo sapiens_hsa012001.47140875
35Dorso-ventral axis formation_Homo sapiens_hsa043201.41333845
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.38577733
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36164834
38Tyrosine metabolism_Homo sapiens_hsa003501.33409926
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23161525
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16847287
41Insulin secretion_Homo sapiens_hsa049111.14224179
42Morphine addiction_Homo sapiens_hsa050321.12039567
43Type I diabetes mellitus_Homo sapiens_hsa049401.11071426
44Arginine biosynthesis_Homo sapiens_hsa002201.06251371
45Mineral absorption_Homo sapiens_hsa049781.05727054
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01219323
47Ether lipid metabolism_Homo sapiens_hsa005651.00195822
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99642300
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.99542465
50Hedgehog signaling pathway_Homo sapiens_hsa043400.99293296
51Huntingtons disease_Homo sapiens_hsa050160.98275236
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97241122
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96076762
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.95505670
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91821443
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.91692573
57Renin secretion_Homo sapiens_hsa049240.88138215
58Long-term potentiation_Homo sapiens_hsa047200.86070072
59Arginine and proline metabolism_Homo sapiens_hsa003300.84615644
60Antigen processing and presentation_Homo sapiens_hsa046120.84177280
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.83017316
62mRNA surveillance pathway_Homo sapiens_hsa030150.82082922
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80128326
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.79467826
65Biosynthesis of amino acids_Homo sapiens_hsa012300.79330149
66Nitrogen metabolism_Homo sapiens_hsa009100.77055356
67Glutamatergic synapse_Homo sapiens_hsa047240.76590571
68Synaptic vesicle cycle_Homo sapiens_hsa047210.75961439
69AMPK signaling pathway_Homo sapiens_hsa041520.75502001
70Estrogen signaling pathway_Homo sapiens_hsa049150.74500433
71One carbon pool by folate_Homo sapiens_hsa006700.71979883
72Bile secretion_Homo sapiens_hsa049760.71692177
73Purine metabolism_Homo sapiens_hsa002300.71290174
74Glutathione metabolism_Homo sapiens_hsa004800.70422026
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68732279
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67772272
77Autoimmune thyroid disease_Homo sapiens_hsa053200.66222222
78Graft-versus-host disease_Homo sapiens_hsa053320.65609327
79Arachidonic acid metabolism_Homo sapiens_hsa005900.64985066
80Tight junction_Homo sapiens_hsa045300.64775831
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.64108891
82Allograft rejection_Homo sapiens_hsa053300.63328690
83Pancreatic secretion_Homo sapiens_hsa049720.62251709
84Endocytosis_Homo sapiens_hsa041440.61863761
85RNA transport_Homo sapiens_hsa030130.60373659
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59688071
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59602632
88Viral myocarditis_Homo sapiens_hsa054160.59468471
89Serotonergic synapse_Homo sapiens_hsa047260.59464084
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59376527
91Thyroid hormone synthesis_Homo sapiens_hsa049180.58520144
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58415017
93beta-Alanine metabolism_Homo sapiens_hsa004100.57439096
94MAPK signaling pathway_Homo sapiens_hsa040100.57409164
95Collecting duct acid secretion_Homo sapiens_hsa049660.56793706
96GABAergic synapse_Homo sapiens_hsa047270.55529977
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52474366
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52036263
99Inositol phosphate metabolism_Homo sapiens_hsa005620.51472083
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50021278
101Retinol metabolism_Homo sapiens_hsa008300.49581011
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49504038
103Fanconi anemia pathway_Homo sapiens_hsa034600.48977744
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.47841222
105Wnt signaling pathway_Homo sapiens_hsa043100.46915483
106Chemical carcinogenesis_Homo sapiens_hsa052040.45638262
107Gastric acid secretion_Homo sapiens_hsa049710.42810167
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41448431
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40510869
110Legionellosis_Homo sapiens_hsa051340.40260718
111Cholinergic synapse_Homo sapiens_hsa047250.39279719
112Tryptophan metabolism_Homo sapiens_hsa003800.37173191
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36608409
114ABC transporters_Homo sapiens_hsa020100.34491405
115VEGF signaling pathway_Homo sapiens_hsa043700.33954293
116cAMP signaling pathway_Homo sapiens_hsa040240.33846938
117Circadian entrainment_Homo sapiens_hsa047130.33178207
118Insulin resistance_Homo sapiens_hsa049310.32828390
119Salivary secretion_Homo sapiens_hsa049700.32295292
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.31894503
121Cocaine addiction_Homo sapiens_hsa050300.31823731
122Adherens junction_Homo sapiens_hsa045200.30972251
123Calcium signaling pathway_Homo sapiens_hsa040200.30597155
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30375700
125Metabolic pathways_Homo sapiens_hsa011000.29522614
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29421784
127Sulfur metabolism_Homo sapiens_hsa009200.28423928
128Sulfur relay system_Homo sapiens_hsa041220.27840296
129Basal cell carcinoma_Homo sapiens_hsa052170.27481802
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27303531
131Renin-angiotensin system_Homo sapiens_hsa046140.26689046
132Type II diabetes mellitus_Homo sapiens_hsa049300.25555512
133Insulin signaling pathway_Homo sapiens_hsa049100.24980192
134Salmonella infection_Homo sapiens_hsa051320.24221768
135Protein digestion and absorption_Homo sapiens_hsa049740.23325763
136Alcoholism_Homo sapiens_hsa050340.22809505
137Taste transduction_Homo sapiens_hsa047420.21758865

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