ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	9.45218462
2	epithelial cilium movement (GO:0003351)	9.19794929
3	spermatid development (GO:0007286)	9.18734962
4	motile cilium assembly (GO:0044458)	8.90064040
5	regulation of cilium movement (GO:0003352)	7.76684522
6	cilium movement (GO:0003341)	7.72726215
7	single fertilization (GO:0007338)	7.61900396
8	sperm capacitation (GO:0048240)	7.51746744
9	male meiosis (GO:0007140)	7.46169268
10	synaptonemal complex assembly (GO:0007130)	7.14574130
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.12768208
12	synaptonemal complex organization (GO:0070193)	7.05598080
13	piRNA metabolic process (GO:0034587)	6.51358913
14	fertilization (GO:0009566)	6.22500110
15	spermatogenesis (GO:0007283)	6.19140938
16	male gamete generation (GO:0048232)	6.16859856
17	microtubule depolymerization (GO:0007019)	6.15065707
18	spermatid nucleus differentiation (GO:0007289)	6.03315356
19	organic cation transport (GO:0015695)	5.99728955
20	negative regulation of inclusion body assembly (GO:0090084)	5.95266208
21	gamete generation (GO:0007276)	5.68751311
22	calcium ion-dependent exocytosis (GO:0017156)	5.37632834
23	cell recognition (GO:0008037)	5.36673657
24	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.32949597
25	microtubule severing (GO:0051013)	5.19692301
26	regulation of inclusion body assembly (GO:0090083)	5.14911812
27	ventricular system development (GO:0021591)	5.10959209
28	germ cell development (GO:0007281)	5.08750446
29	chromosome organization involved in meiosis (GO:0070192)	4.91192845
30	regulation of microtubule-based movement (GO:0060632)	4.49450534
31	chromosome condensation (GO:0030261)	4.49339825
32	multicellular organismal reproductive process (GO:0048609)	4.45978704
33	male meiosis I (GO:0007141)	4.44754475
34	meiotic nuclear division (GO:0007126)	4.31068578
35	glycerol ether metabolic process (GO:0006662)	4.28382219
36	DNA methylation involved in gamete generation (GO:0043046)	4.27743590
37	monoubiquitinated protein deubiquitination (GO:0035520)	4.24436363
38	DNA packaging (GO:0006323)	4.22632138
39	seminiferous tubule development (GO:0072520)	4.10274944
40	ether metabolic process (GO:0018904)	3.95710980
41	protein polyglutamylation (GO:0018095)	3.87404206
42	chaperone-mediated protein complex assembly (GO:0051131)	3.79705562
43	single strand break repair (GO:0000012)	3.70641767
44	protein K11-linked deubiquitination (GO:0035871)	3.68536361
45	multicellular organismal development (GO:0007275)	3.57189615
46	meiosis I (GO:0007127)	3.57001110
47	sexual reproduction (GO:0019953)	3.53101899
48	left/right pattern formation (GO:0060972)	3.52043070
49	positive regulation of macrophage activation (GO:0043032)	3.35153101
50	regulation of spindle checkpoint (GO:0090231)	3.32635942
51	genitalia morphogenesis (GO:0035112)	3.31816433
52	sequestering of actin monomers (GO:0042989)	3.27967008
53	microtubule polymerization or depolymerization (GO:0031109)	3.24291949
54	amino-acid betaine transport (GO:0015838)	3.09854398
55	carnitine transport (GO:0015879)	3.09854398
56	protein localization to cilium (GO:0061512)	3.08396159
57	synapsis (GO:0007129)	2.98348263
58	carnitine transmembrane transport (GO:1902603)	2.97557959
59	meiotic cell cycle (GO:0051321)	2.96184871
60	nucleus organization (GO:0006997)	2.95576415
61	centriole assembly (GO:0098534)	2.93872290
62	intraciliary transport (GO:0042073)	2.81229391
63	cilium organization (GO:0044782)	2.80058774
64	cellular component assembly involved in morphogenesis (GO:0010927)	2.79877615
65	polyol catabolic process (GO:0046174)	2.79311043
66	meiotic cell cycle process (GO:1903046)	2.76773168
67	centriole replication (GO:0007099)	2.73925324
68	microtubule-based movement (GO:0007018)	2.72718234
69	cilium morphogenesis (GO:0060271)	2.68466409
70	nucleoside diphosphate phosphorylation (GO:0006165)	2.68342394
71	glycolytic process (GO:0006096)	2.68089531
72	cilium assembly (GO:0042384)	2.67977338
73	alditol metabolic process (GO:0019400)	2.64344788
74	protein refolding (GO:0042026)	2.63221960
75	interferon-gamma secretion (GO:0072643)	2.60035854
76	axoneme assembly (GO:0035082)	2.56029204
77	mitotic sister chromatid cohesion (GO:0007064)	2.55836220
78	GTP biosynthetic process (GO:0006183)	2.55178898
79	negative regulation of organelle assembly (GO:1902116)	2.55019616
80	regulation of centriole replication (GO:0046599)	2.53091914
81	lactate metabolic process (GO:0006089)	2.48677253
82	peptidyl-glutamic acid modification (GO:0018200)	2.47234395
83	single-organism membrane fusion (GO:0044801)	2.38145769
84	gene silencing by RNA (GO:0031047)	2.38050480
85	calcium ion import (GO:0070509)	2.38003718
86	nuclear pore complex assembly (GO:0051292)	2.35414956
87	peptidyl-threonine dephosphorylation (GO:0035970)	2.31922422
88	cell wall macromolecule catabolic process (GO:0016998)	16.0106782
89	cell wall macromolecule metabolic process (GO:0044036)	16.0106782
90	fusion of sperm to egg plasma membrane (GO:0007342)	14.3862480
91	acrosome assembly (GO:0001675)	13.4834197
92	sperm motility (GO:0030317)	12.6941372
93	sperm-egg recognition (GO:0035036)	12.2762442
94	multicellular organism reproduction (GO:0032504)	12.1987169
95	acrosome reaction (GO:0007340)	11.1986498
96	cell-cell recognition (GO:0009988)	11.0053926
97	plasma membrane fusion (GO:0045026)	10.9548441
98	binding of sperm to zona pellucida (GO:0007339)	10.6317278
99	reproduction (GO:0000003)	10.2725618
100	cilium or flagellum-dependent cell motility (GO:0001539)	10.0092570

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.40539664
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.95144237
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.92313915
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.04616743
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.81076627
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.80496302
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.47685924
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.44114819
9	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.30747702
10	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.24602989
11	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.20334151
12	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	2.17373534
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14623950
14	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.11564450
15	VDR_22108803_ChIP-Seq_LS180_Human	2.07308857
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.04554243
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.02897255
18	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.96625239
19	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.94183190
20	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.91895911
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.89903722
22	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.82263564
23	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.71869101
24	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.68805279
25	STAT1_17558387_ChIP-Seq_HELA_Human	1.68321986
26	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.64982152
27	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.62570875
28	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60883432
29	KDM2B_26808549_Chip-Seq_REH_Human	1.60256467
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59022028
31	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.55772568
32	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.52989612
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.51724624
34	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.47434810
35	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.46899639
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46005000
37	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.45997337
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.45008807
39	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.43735538
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42916775
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.42916775
42	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.41581321
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41296676
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37292433
45	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.36368360
46	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33383420
47	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.33057098
48	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.30754057
49	GF1_26923725_Chip-Seq_HPCs_Mouse	1.28469822
50	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.27211269
51	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.24459836
52	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23631147
53	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.22811192
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22178861
55	P53_21459846_ChIP-Seq_SAOS-2_Human	1.20945384
56	P53_22387025_ChIP-Seq_ESCs_Mouse	1.20848588
57	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.19934401
58	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.19604396
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18767416
60	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.18749078
61	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17991565
62	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.17739030
63	P300_18555785_Chip-Seq_ESCs_Mouse	1.17614347
64	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.16199838
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16138425
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14697790
67	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.14148514
68	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.14028547
69	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.13927723
70	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.12095438
71	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.11866744
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08760068
73	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.06877469
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.06794943
75	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.05643713
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05091687
77	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.04574154
78	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.04154499
79	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04126262
80	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02416250
81	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02366256
82	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02366256
83	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.02151731
84	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.99964406
85	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.98680796
86	PU1_27457419_Chip-Seq_LIVER_Mouse	0.97581465
87	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.97400340
88	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.97099863
89	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.96593411
90	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.96446443
91	SOX9_26525672_Chip-Seq_HEART_Mouse	0.96381948
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96375318
93	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.96153173
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95815834
95	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.94319379
96	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.92794897
97	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.92584649
98	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.91897013
99	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91587763
100	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.90930815

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.08546355
2	MP0001929_abnormal_gametogenesis	5.60318934
3	MP0008877_abnormal_DNA_methylation	4.36758600
4	MP0002210_abnormal_sex_determination	3.52597634
5	MP0002161_abnormal_fertility/fecundity	3.28961598
6	MP0002653_abnormal_ependyma_morphology	3.07914074
7	MP0001145_abnormal_male_reproductive	3.04125164
8	MP0000653_abnormal_sex_gland	2.67111555
9	MP0005670_abnormal_white_adipose	2.23104418
10	MP0005410_abnormal_fertilization	16.0723661
11	MP0005623_abnormal_meninges_morphology	1.93699378
12	MP0004233_abnormal_muscle_weight	1.74471885
13	MP0009046_muscle_twitch	1.58813204
14	MP0002160_abnormal_reproductive_system	1.58736366
15	MP0003646_muscle_fatigue	1.53004705
16	MP0008058_abnormal_DNA_repair	1.47290205
17	MP0002282_abnormal_trachea_morphology	1.21700250
18	MP0001984_abnormal_olfaction	1.18461866
19	MP0001765_abnormal_ion_homeostasis	1.01413064
20	MP0002234_abnormal_pharynx_morphology	1.00642640
21	MP0005647_abnormal_sex_gland	0.99885983
22	MP0010094_abnormal_chromosome_stability	0.85633019
23	MP0008057_abnormal_DNA_replication	0.85512312
24	MP0005389_reproductive_system_phenotype	0.83662271
25	MP0002102_abnormal_ear_morphology	0.74128024
26	MP0004036_abnormal_muscle_relaxation	0.63460929
27	MP0003699_abnormal_female_reproductive	0.59942219
28	MP0002928_abnormal_bile_duct	0.58422648
29	MP0008995_early_reproductive_senescence	0.58116937
30	MP0005636_abnormal_mineral_homeostasis	0.56396701
31	MP0003950_abnormal_plasma_membrane	0.53513724
32	MP0003011_delayed_dark_adaptation	0.52797507
33	MP0010307_abnormal_tumor_latency	0.52512064
34	MP0001293_anophthalmia	0.51693225
35	MP0003111_abnormal_nucleus_morphology	0.51610221
36	MP0003115_abnormal_respiratory_system	0.50949699
37	MP0003878_abnormal_ear_physiology	0.50340988
38	MP0005377_hearing/vestibular/ear_phenot	0.50340988
39	MP0001324_abnormal_eye_pigmentation	0.48557868
40	MP0002269_muscular_atrophy	0.46189552
41	MP0008007_abnormal_cellular_replicative	0.43922551
42	MP0001730_embryonic_growth_arrest	0.43497387
43	MP0006036_abnormal_mitochondrial_physio	0.43355661
44	MP0001119_abnormal_female_reproductive	0.43073905
45	MP0005551_abnormal_eye_electrophysiolog	0.42094833
46	MP0004084_abnormal_cardiac_muscle	0.41129118
47	MP0000358_abnormal_cell_content/	0.39566605
48	MP0003786_premature_aging	0.39229097
49	MP0002132_abnormal_respiratory_system	0.38687355
50	MP0001764_abnormal_homeostasis	0.36689315
51	MP0005253_abnormal_eye_physiology	0.35128687
52	MP0004133_heterotaxia	0.35093268
53	MP0004019_abnormal_vitamin_homeostasis	0.35063599
54	MP0003633_abnormal_nervous_system	0.34509690
55	MP0005666_abnormal_adipose_tissue	0.31917947
56	MP0001545_abnormal_hematopoietic_system	0.31159823
57	MP0005397_hematopoietic_system_phenotyp	0.31159823
58	MP0002736_abnormal_nociception_after	0.28477158
59	MP0009697_abnormal_copulation	0.28224661
60	MP0003861_abnormal_nervous_system	0.28171127
61	MP0005391_vision/eye_phenotype	0.27698177
62	MP0000313_abnormal_cell_death	0.27220779
63	MP0002084_abnormal_developmental_patter	0.27022055
64	MP0009115_abnormal_fat_cell	0.26757878
65	MP0002139_abnormal_hepatobiliary_system	0.24649337
66	MP0001672_abnormal_embryogenesis/_devel	0.24443430
67	MP0005380_embryogenesis_phenotype	0.24443430
68	MP0004811_abnormal_neuron_physiology	0.23791362
69	MP0002971_abnormal_brown_adipose	0.23354102
70	MP0002152_abnormal_brain_morphology	0.23047282
71	MP0005365_abnormal_bile_salt	0.22710466
72	MP0003631_nervous_system_phenotype	0.22626055
73	MP0003077_abnormal_cell_cycle	0.22498348
74	MP0000432_abnormal_head_morphology	0.22490395
75	MP0003984_embryonic_growth_retardation	0.22361044
76	MP0003329_amyloid_beta_deposits	0.21844491
77	MP0001697_abnormal_embryo_size	0.21286831
78	MP0002169_no_abnormal_phenotype	0.20849981
79	MP0003787_abnormal_imprinting	0.20696141
80	MP0008875_abnormal_xenobiotic_pharmacok	0.20648602
81	MP0002873_normal_phenotype	0.20577473
82	MP0002088_abnormal_embryonic_growth/wei	0.19550865
83	MP0006035_abnormal_mitochondrial_morpho	0.18227795
84	MP0000534_abnormal_ureter_morphology	0.17851666
85	MP0004808_abnormal_hematopoietic_stem	0.16736768
86	MP0005195_abnormal_posterior_eye	0.16702491
87	MP0002085_abnormal_embryonic_tissue	0.16095950
88	MP0004145_abnormal_muscle_electrophysio	0.15720870
89	MP0001968_abnormal_touch/_nociception	0.15020765
90	MP0003879_abnormal_hair_cell	0.14354901
91	MP0000001_mammalian_phenotype	0.14124826
92	MP0003943_abnormal_hepatobiliary_system	0.14088271
93	MP0002080_prenatal_lethality	0.14001169
94	MP0002837_dystrophic_cardiac_calcinosis	0.13889029
95	MP0005319_abnormal_enzyme/_coenzyme	0.13466349
96	MP0009250_abnormal_appendicular_skeleto	0.13449535
97	MP0002092_abnormal_eye_morphology	0.13314912
98	MP0003948_abnormal_gas_homeostasis	0.12573533
99	MP0000569_abnormal_digit_pigmentation	0.12335103
100	MP0005257_abnormal_intraocular_pressure	0.11963117

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium physiology (HP:0012261)	9.57732130
2	Abnormal respiratory epithelium morphology (HP:0012253)	8.81540022
3	Abnormal respiratory motile cilium morphology (HP:0005938)	8.81540022
4	Abnormal ciliary motility (HP:0012262)	7.84177879
5	Rhinitis (HP:0012384)	7.82854123
6	Chronic bronchitis (HP:0004469)	7.41291600
7	Nasal polyposis (HP:0100582)	6.40499628
8	Infertility (HP:0000789)	6.26776046
9	Abnormality of the nasal mucosa (HP:0000433)	5.24963023
10	Bronchitis (HP:0012387)	4.62197307
11	Bronchiectasis (HP:0002110)	4.53594058
12	Male infertility (HP:0003251)	4.31108384
13	Nephronophthisis (HP:0000090)	4.07931377
14	Abnormal spermatogenesis (HP:0008669)	3.82275970
15	Recurrent sinusitis (HP:0011108)	3.54837029
16	Recurrent otitis media (HP:0000403)	3.30322911
17	Medial flaring of the eyebrow (HP:0010747)	3.25242417
18	Abnormality of the renal medulla (HP:0100957)	3.03906015
19	Abnormality of midbrain morphology (HP:0002418)	2.95335735
20	Molar tooth sign on MRI (HP:0002419)	2.95335735
21	Azoospermia (HP:0000027)	2.84518545
22	Recurrent bronchitis (HP:0002837)	2.76134445
23	Tubular atrophy (HP:0000092)	2.58897371
24	Tubulointerstitial nephritis (HP:0001970)	2.47319875
25	Impulsivity (HP:0100710)	2.44823051
26	Tongue fasciculations (HP:0001308)	2.34355357
27	Tubulointerstitial abnormality (HP:0001969)	2.32548512
28	Muscle fibrillation (HP:0010546)	2.15429333
29	Congenital primary aphakia (HP:0007707)	2.11955838
30	Gait imbalance (HP:0002141)	2.11632768
31	Tubulointerstitial fibrosis (HP:0005576)	2.02940380
32	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.8491107
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	12.5625153
34	Absent/shortened dynein arms (HP:0200106)	12.5625153
35	Pancreatic fibrosis (HP:0100732)	1.99564000
36	Postaxial foot polydactyly (HP:0001830)	1.91111811
37	Congenital hepatic fibrosis (HP:0002612)	1.90752040
38	Chronic sinusitis (HP:0011109)	1.87461762
39	Abnormality of saccadic eye movements (HP:0000570)	1.86494428
40	Decreased central vision (HP:0007663)	1.86111900
41	Microglossia (HP:0000171)	1.85444277
42	Polydipsia (HP:0001959)	1.82804315
43	Abnormal drinking behavior (HP:0030082)	1.82804315
44	Nephrogenic diabetes insipidus (HP:0009806)	1.80589379
45	Dyschromatopsia (HP:0007641)	1.75193015
46	Facial cleft (HP:0002006)	1.75174241
47	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.74494248
48	Aplasia/Hypoplasia of the lens (HP:0008063)	1.72393370
49	Gonadotropin excess (HP:0000837)	1.72068061
50	Genital tract atresia (HP:0001827)	1.69644391
51	Postaxial hand polydactyly (HP:0001162)	1.67960727
52	Stage 5 chronic kidney disease (HP:0003774)	1.65873405
53	Abnormality of renal excretion (HP:0011036)	1.64255139
54	Renal dysplasia (HP:0000110)	1.63175919
55	Cholecystitis (HP:0001082)	1.62737501
56	Abnormal gallbladder physiology (HP:0012438)	1.62737501
57	Poor coordination (HP:0002370)	1.61283099
58	Vaginal atresia (HP:0000148)	1.60736063
59	Abnormality of the renal cortex (HP:0011035)	1.60735513
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.59095688
61	Bile duct proliferation (HP:0001408)	1.58605585
62	Abnormal biliary tract physiology (HP:0012439)	1.58605585
63	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.58003444
64	Short ribs (HP:0000773)	1.57693776
65	Optic nerve hypoplasia (HP:0000609)	1.57449611
66	Fibular hypoplasia (HP:0003038)	1.57429315
67	Abnormality of ocular smooth pursuit (HP:0000617)	1.54268590
68	Impaired smooth pursuit (HP:0007772)	1.51190622
69	Congenital malformation of the right heart (HP:0011723)	1.50702699
70	Double outlet right ventricle (HP:0001719)	1.50702699
71	Oculomotor apraxia (HP:0000657)	1.50597788
72	Spastic tetraparesis (HP:0001285)	1.50077514
73	Cystic liver disease (HP:0006706)	1.47946715
74	Abnormality of permanent molar morphology (HP:0011071)	1.46092537
75	Abnormality of the dental root (HP:0006486)	1.46092537
76	Taurodontia (HP:0000679)	1.46092537
77	Median cleft lip (HP:0000161)	1.45436363
78	Heterotopia (HP:0002282)	1.44676835
79	Absent frontal sinuses (HP:0002688)	1.42608779
80	Abnormality of molar morphology (HP:0011070)	1.36842472
81	Abnormality of molar (HP:0011077)	1.36842472
82	Absent epiphyses (HP:0010577)	1.36469121
83	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.36469121
84	Easy fatigability (HP:0003388)	1.35030825
85	Chronic hepatic failure (HP:0100626)	1.34810174
86	Abnormality of the lower motor neuron (HP:0002366)	1.34596827
87	Abnormality of the dental pulp (HP:0006479)	1.33583445
88	Bundle branch block (HP:0011710)	1.33559208
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.32159503
90	J-shaped sella turcica (HP:0002680)	1.31775807
91	Choroideremia (HP:0001139)	1.31365726
92	Cerebellar dysplasia (HP:0007033)	1.31183191
93	True hermaphroditism (HP:0010459)	1.30687152
94	Abnormal urine output (HP:0012590)	1.29675128
95	Asymmetric septal hypertrophy (HP:0001670)	1.27063117
96	Pancreatic cysts (HP:0001737)	1.25264642
97	Abnormality of the neuromuscular junction (HP:0003398)	1.24991754
98	Fatigable weakness (HP:0003473)	1.24991754
99	Deformed sella turcica (HP:0002681)	1.24246948
100	Supernumerary spleens (HP:0009799)	1.20754420

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	8.51856200
2	PDK4	8.51856200
3	TESK1	5.59958788
4	PDK2	5.51831153
5	PRKD3	4.05954098
6	ICK	3.65091240
7	PTK2B	2.50755447
8	STK39	2.38664573
9	WNK4	2.35211201
10	STK38	1.93267941
11	NEK2	1.76591919
12	PNCK	1.30101809
13	BRSK2	1.25236172
14	PDK1	1.23828380
15	DYRK1B	1.10433283
16	STK38L	1.07923032
17	LMTK2	0.92929698
18	CHEK2	0.91828940
19	PLK4	0.89412608
20	DYRK3	0.89196452
21	WEE1	0.88723450
22	CCNB1	0.87860318
23	TYRO3	0.86404605
24	STK3	0.80736132
25	IRAK1	0.78840506
26	TTK	0.77261969
27	PDPK1	0.74476788
28	WNK1	0.73384713
29	TESK2	0.66965947
30	BRSK1	0.61575254
31	RIPK4	0.59881427
32	PASK	0.58763722
33	MAPK15	0.51523011
34	CHEK1	0.51499115
35	MAP2K6	0.49225368
36	PINK1	0.47548902
37	MAP2K7	0.45262507
38	MARK3	0.44055974
39	EEF2K	0.43091289
40	CDK12	0.41824037
41	CDC7	0.38070727
42	PAK1	0.37835209
43	IRAK2	0.37658617
44	PLK1	0.35836981
45	PRKCG	0.35262455
46	MUSK	0.33886301
47	ATM	0.33619291
48	ATR	0.33448173
49	NEK6	0.31614529
50	ZAP70	0.24453962
51	NTRK2	0.23606788
52	MAP3K4	0.22782669
53	CAMK1G	0.21744296
54	PRKAA1	0.21335615
55	PAK2	0.20381772
56	PKN1	0.19811782
57	MTOR	0.17035837
58	STK10	0.17011952
59	MAPKAPK5	0.16616465
60	BUB1	0.16282768
61	PDGFRB	0.16111055
62	RPS6KB1	0.14600057
63	MARK2	0.14082973
64	PRKCZ	0.13940398
65	PRKG2	0.13714144
66	PRKCQ	0.13288126
67	BRAF	0.13282511
68	CSNK2A1	0.12247167
69	CDK15	0.11727769
70	CSNK2A2	0.10692122
71	CAMKK1	0.10352305
72	CDK2	0.10061461
73	AURKA	0.09810122
74	CDK1	0.09322909
75	CDK18	0.08879775
76	CDK11A	0.08136025
77	STK11	0.07945442
78	GSK3B	0.07720136
79	RPS6KA1	0.07611913
80	PRKG1	0.07608551
81	MAP3K10	0.07588189
82	CDK4	0.07261897
83	YES1	0.06955563
84	AKT3	0.06687475
85	LATS1	0.06598785
86	RIPK1	0.06011811
87	PAK4	0.04795952
88	PRKACG	0.04484295
89	MAPK8	0.04364760
90	OBSCN	0.03634284
91	CDK14	0.03616583
92	CSF1R	0.03386674
93	OXSR1	0.02914712
94	CDK3	0.02647517
95	MAP3K5	0.02551975
96	AURKB	0.02183385
97	EGFR	0.01882361
98	CAMK2A	0.01697157
99	PRKCD	0.01565571
100	CSNK1D	0.01247603

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.65202812
2	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.05832643
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.87868227
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.43216127
5	Basal transcription factors_Homo sapiens_hsa03022	3.30786111
6	Pentose phosphate pathway_Homo sapiens_hsa00030	3.01935048
7	Propanoate metabolism_Homo sapiens_hsa00640	2.87987819
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.74169750
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.70586090
10	Glucagon signaling pathway_Homo sapiens_hsa04922	2.54775102
11	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.42584910
12	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.12697015
13	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.03686442
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.95402899
15	Oocyte meiosis_Homo sapiens_hsa04114	1.92327381
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.90318765
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.85881972
18	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.83404553
19	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.68327962
20	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.65883652
21	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.64980822
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.64438899
23	Carbon metabolism_Homo sapiens_hsa01200	1.58538274
24	Renin-angiotensin system_Homo sapiens_hsa04614	1.52494391
25	Mineral absorption_Homo sapiens_hsa04978	1.45178767
26	Amphetamine addiction_Homo sapiens_hsa05031	1.42969838
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35104307
28	Fat digestion and absorption_Homo sapiens_hsa04975	1.33506141
29	Huntingtons disease_Homo sapiens_hsa05016	1.32376602
30	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.31481633
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.29286733
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27973513
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.25266584
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.25052683
35	Purine metabolism_Homo sapiens_hsa00230	1.20791861
36	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.20313070
37	RNA transport_Homo sapiens_hsa03013	1.17967105
38	mRNA surveillance pathway_Homo sapiens_hsa03015	1.10446237
39	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.09113174
40	Fatty acid degradation_Homo sapiens_hsa00071	1.02454144
41	Fatty acid metabolism_Homo sapiens_hsa01212	1.01861230
42	Glutathione metabolism_Homo sapiens_hsa00480	1.00684580
43	Renin secretion_Homo sapiens_hsa04924	0.96019184
44	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.93474309
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89184789
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.88714975
47	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.85505086
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83162403
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82298701
50	Antigen processing and presentation_Homo sapiens_hsa04612	0.81015220
51	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80371149
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73202170
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70158388
54	Insulin secretion_Homo sapiens_hsa04911	0.69932562
55	Long-term potentiation_Homo sapiens_hsa04720	0.63872816
56	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.63154345
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62665090
58	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.60943635
59	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.56728983
60	Estrogen signaling pathway_Homo sapiens_hsa04915	0.56043040
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55270206
62	Bile secretion_Homo sapiens_hsa04976	0.54398667
63	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.50724220
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.49853704
65	Homologous recombination_Homo sapiens_hsa03440	0.49209416
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.48191845
67	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.46338961
68	Metabolic pathways_Homo sapiens_hsa01100	0.46207582
69	Cell cycle_Homo sapiens_hsa04110	0.44392672
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.43708923
71	Pancreatic secretion_Homo sapiens_hsa04972	0.42965549
72	AMPK signaling pathway_Homo sapiens_hsa04152	0.42747795
73	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.42077083
74	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41290750
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.40145653
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39141282
77	Taste transduction_Homo sapiens_hsa04742	0.37742788
78	Protein digestion and absorption_Homo sapiens_hsa04974	0.37733230
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37409575
80	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.37406354
81	Endocytosis_Homo sapiens_hsa04144	0.37188693
82	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.35520898
83	ABC transporters_Homo sapiens_hsa02010	0.33758095
84	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.33329329
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.33043678
86	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.32928116
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32429464
88	Sulfur metabolism_Homo sapiens_hsa00920	0.30342166
89	Salivary secretion_Homo sapiens_hsa04970	0.29943604
90	Alcoholism_Homo sapiens_hsa05034	0.28554939
91	Lysine degradation_Homo sapiens_hsa00310	0.27680869
92	Legionellosis_Homo sapiens_hsa05134	0.25400180
93	Viral carcinogenesis_Homo sapiens_hsa05203	0.24403392
94	cAMP signaling pathway_Homo sapiens_hsa04024	0.22657726
95	Gastric acid secretion_Homo sapiens_hsa04971	0.21340886
96	RNA degradation_Homo sapiens_hsa03018	0.19961969
97	Cocaine addiction_Homo sapiens_hsa05030	0.19072294
98	Salmonella infection_Homo sapiens_hsa05132	0.12594582
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.12583576
100	VEGF signaling pathway_Homo sapiens_hsa04370	0.11791950

TEX43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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