TF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)9.00716799
2regulation of fibrinolysis (GO:0051917)8.50802468
3regulation of protein activation cascade (GO:2000257)7.54175505
4protein carboxylation (GO:0018214)7.22913223
5peptidyl-glutamic acid carboxylation (GO:0017187)7.22913223
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.20322004
7L-phenylalanine catabolic process (GO:0006559)7.20322004
8regulation of complement activation (GO:0030449)7.17998410
9L-phenylalanine metabolic process (GO:0006558)6.69526233
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.69526233
11complement activation, alternative pathway (GO:0006957)6.41155041
12blood coagulation, intrinsic pathway (GO:0007597)6.29343595
13very-low-density lipoprotein particle assembly (GO:0034379)6.28978654
14fibrinolysis (GO:0042730)5.82764002
15exogenous drug catabolic process (GO:0042738)5.81069352
16intestinal cholesterol absorption (GO:0030299)5.74364545
17negative regulation of cholesterol transport (GO:0032375)5.71877377
18negative regulation of sterol transport (GO:0032372)5.71877377
19regulation of plasminogen activation (GO:0010755)5.69977115
20plasma lipoprotein particle assembly (GO:0034377)5.65348357
21regulation of cholesterol esterification (GO:0010872)5.58210417
22cholesterol efflux (GO:0033344)5.56457496
23protein-lipid complex remodeling (GO:0034368)5.50934005
24macromolecular complex remodeling (GO:0034367)5.50934005
25plasma lipoprotein particle remodeling (GO:0034369)5.50934005
26drug catabolic process (GO:0042737)5.45125502
27epoxygenase P450 pathway (GO:0019373)5.44649886
28glyoxylate metabolic process (GO:0046487)5.35629935
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.32675638
30low-density lipoprotein particle remodeling (GO:0034374)5.24126813
31high-density lipoprotein particle remodeling (GO:0034375)5.16764042
32protein-lipid complex assembly (GO:0065005)5.13769504
33ethanol oxidation (GO:0006069)5.12741618
34regulation of apoptotic cell clearance (GO:2000425)5.02353009
35omega-hydroxylase P450 pathway (GO:0097267)4.81971472
36negative regulation of protein activation cascade (GO:2000258)4.79259377
37reverse cholesterol transport (GO:0043691)4.77312781
38urea metabolic process (GO:0019627)4.76834055
39aromatic amino acid family catabolic process (GO:0009074)4.75685354
40phospholipid efflux (GO:0033700)4.71012950
41plasma lipoprotein particle organization (GO:0071827)4.70176890
42negative regulation of blood coagulation (GO:0030195)4.67148700
43negative regulation of hemostasis (GO:1900047)4.67148700
44plasma lipoprotein particle clearance (GO:0034381)4.65631192
45cellular glucuronidation (GO:0052695)4.51886910
46protein-lipid complex subunit organization (GO:0071825)4.47810938
47protein activation cascade (GO:0072376)4.45853036
48positive regulation of hemostasis (GO:1900048)4.39299624
49positive regulation of blood coagulation (GO:0030194)4.39299624
50acylglycerol homeostasis (GO:0055090)4.31984114
51triglyceride homeostasis (GO:0070328)4.31984114
52acute-phase response (GO:0006953)4.30063627
53regulation of humoral immune response (GO:0002920)4.29881516
54nitrogen cycle metabolic process (GO:0071941)4.29552530
55positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.29365387
56glutamate metabolic process (GO:0006536)4.27437386
57negative regulation of coagulation (GO:0050819)4.26499140
58uronic acid metabolic process (GO:0006063)4.24379741
59glucuronate metabolic process (GO:0019585)4.24379741
60bile acid metabolic process (GO:0008206)4.23470577
61positive regulation of triglyceride lipase activity (GO:0061365)4.18412413
62positive regulation of lipoprotein lipase activity (GO:0051006)4.18412413
63urea cycle (GO:0000050)4.16652890
64ethanol metabolic process (GO:0006067)4.14318742
65negative regulation of lipase activity (GO:0060192)4.11531481
66negative regulation of wound healing (GO:0061045)4.10527484
67serine family amino acid catabolic process (GO:0009071)4.09963891
68regulation of bile acid biosynthetic process (GO:0070857)4.06693259
69positive regulation of coagulation (GO:0050820)4.04259288
70bile acid biosynthetic process (GO:0006699)4.02831986
71complement activation, classical pathway (GO:0006958)3.99273690
72negative regulation of complement activation (GO:0045916)3.82539660
73regulation of cholesterol biosynthetic process (GO:0045540)3.81341244
74drug metabolic process (GO:0017144)3.79644366
75imidazole-containing compound metabolic process (GO:0052803)3.79519350
76glycine metabolic process (GO:0006544)3.72792841
77complement activation (GO:0006956)3.71599921
78lipoprotein metabolic process (GO:0042157)3.69693523
79regulation of cholesterol homeostasis (GO:2000188)3.61828526
80tyrosine metabolic process (GO:0006570)3.60573284
81cholesterol homeostasis (GO:0042632)3.59620455
82bile acid and bile salt transport (GO:0015721)3.58806092
83proline metabolic process (GO:0006560)3.58159017
84sterol homeostasis (GO:0055092)3.54673041
85cholesterol transport (GO:0030301)3.50772188
86sterol transport (GO:0015918)3.50772188
87intestinal absorption (GO:0050892)3.50583201
88positive regulation of extracellular matrix organization (GO:1903055)3.46991828
89regulation of triglyceride catabolic process (GO:0010896)3.44242653
90positive regulation of fatty acid biosynthetic process (GO:0045723)3.44041316
91response to mercury ion (GO:0046689)3.43970961
92amino-acid betaine metabolic process (GO:0006577)3.41795648
93phenylpropanoid metabolic process (GO:0009698)3.39811632
94cytolysis (GO:0019835)3.39479264
95oxidative demethylation (GO:0070989)3.39002784
96dicarboxylic acid biosynthetic process (GO:0043650)3.33170332
97sodium-independent organic anion transport (GO:0043252)3.32603898
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.29932738
99regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.28641170
100alpha-amino acid catabolic process (GO:1901606)3.28337410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.36527290
2PPARA_22158963_ChIP-Seq_LIVER_Mouse5.32011635
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.28727463
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.82570451
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.33893103
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01771253
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97511536
8* FOXA2_19822575_ChIP-Seq_HepG2_Human3.79424275
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.73128400
10* HNF4A_19822575_ChIP-Seq_HepG2_Human2.91200120
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.79597956
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75943359
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.46496774
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.23615040
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8336446
16ESR1_15608294_ChIP-ChIP_MCF-7_Human1.86981233
17CLOCK_20551151_ChIP-Seq_293T_Human1.80112092
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69428817
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68194272
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50191260
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45858413
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42653536
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.41991767
24ZNF263_19887448_ChIP-Seq_K562_Human1.39422229
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.33023153
26SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29799537
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29465580
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.28755607
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22129808
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.22017363
31GATA4_25053715_ChIP-Seq_YYC3_Human1.18313734
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12906425
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11929927
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09231200
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.07619857
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05510111
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02947823
38RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01197918
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00738134
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00282037
41DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99803338
42* LXR_22292898_ChIP-Seq_THP-1_Human0.99280185
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97256010
44SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96976433
45CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96620086
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96039935
47GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91852343
48GATA6_25053715_ChIP-Seq_YYC3_Human0.91807832
49NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91176842
50ERG_21242973_ChIP-ChIP_JURKAT_Human0.89416171
51* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88856138
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88384106
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87185140
54POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87178066
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86216314
56HTT_18923047_ChIP-ChIP_STHdh_Human0.85897997
57TP63_17297297_ChIP-ChIP_HaCaT_Human0.82606104
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77333375
59STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77059022
60FOXA1_25552417_ChIP-Seq_VCAP_Human0.76570031
61KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76510403
62HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76061476
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75686595
64AR_21909140_ChIP-Seq_LNCAP_Human0.74987431
65SOX2_20726797_ChIP-Seq_SW620_Human0.74546579
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73673621
67MYC_19915707_ChIP-ChIP_AK7_Human0.73619314
68ESR1_21235772_ChIP-Seq_MCF-7_Human0.73495650
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72899165
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72820039
71* ESR1_20079471_ChIP-ChIP_T-47D_Human0.71604018
72AR_21572438_ChIP-Seq_LNCaP_Human0.71377812
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68729281
74DROSHA_22980978_ChIP-Seq_HELA_Human0.68454135
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68174734
76SMC4_20622854_ChIP-Seq_HELA_Human0.67448012
77RARA_24833708_ChIP-Seq_LIVER_Mouse0.66948888
78SMAD1_18555785_Chip-Seq_ESCs_Mouse0.66927195
79TP53_16413492_ChIP-PET_HCT116_Human0.66492880
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.65763751
81NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.65138198
82PCGF2_27294783_Chip-Seq_NPCs_Mouse0.64116714
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64055111
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.62931545
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.62392619
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.60688532
87GATA1_19941827_ChIP-Seq_MEL_Mouse0.60609205
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.60134382
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59968090
90SOX2_21211035_ChIP-Seq_LN229_Human0.58027143
91ZFP281_18757296_ChIP-ChIP_E14_Mouse0.57071210
92RUNX1_27457419_Chip-Seq_LIVER_Mouse0.57040562
93ESRRB_18555785_Chip-Seq_ESCs_Mouse0.56913538
94* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.56757506
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.52619493
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.52580338
97* CEBPB_22108803_ChIP-Seq_LS180_Human0.51990074
98SOX11_22085726_ChIP-Seq_ESNs_Mouse0.51632231
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.50672689
100PU1_27457419_Chip-Seq_LIVER_Mouse0.50022300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.74083578
2MP0005360_urolithiasis5.92697069
3MP0005365_abnormal_bile_salt5.79188328
4MP0005085_abnormal_gallbladder_physiolo5.26410857
5MP0003195_calcinosis5.19624972
6MP0008875_abnormal_xenobiotic_pharmacok4.59628988
7MP0001666_abnormal_nutrient_absorption3.84483082
8MP0010329_abnormal_lipoprotein_level3.63927568
9MP0003252_abnormal_bile_duct3.51270206
10MP0003868_abnormal_feces_composition3.21911914
11MP0003122_maternal_imprinting3.06758202
12MP0002138_abnormal_hepatobiliary_system2.33727037
13MP0009840_abnormal_foam_cell2.32404929
14MP0005332_abnormal_amino_acid2.12026890
15MP0000609_abnormal_liver_physiology1.87249088
16MP0002118_abnormal_lipid_homeostasis1.85239232
17MP0005408_hypopigmentation1.84844731
18MP0000566_synostosis1.84587560
19MP0003123_paternal_imprinting1.68650579
20MP0009697_abnormal_copulation1.67376883
21MP0003191_abnormal_cellular_cholesterol1.63072654
22MP0001915_intracranial_hemorrhage1.58775983
23MP0002876_abnormal_thyroid_physiology1.58122400
24MP0010368_abnormal_lymphatic_system1.49650713
25MP0002089_abnormal_postnatal_growth/wei1.49635990
26MP0003690_abnormal_glial_cell1.44479711
27MP0005058_abnormal_lysosome_morphology1.40200619
28MP0000604_amyloidosis1.37736946
29MP0005451_abnormal_body_composition1.35549018
30MP0000920_abnormal_myelination1.28469035
31MP0003172_abnormal_lysosome_physiology1.27638589
32MP0003329_amyloid_beta_deposits1.26919685
33MP0001661_extended_life_span1.22772816
34MP0003806_abnormal_nucleotide_metabolis1.20279889
35MP0004019_abnormal_vitamin_homeostasis1.19956616
36MP0001764_abnormal_homeostasis1.15943712
37MP0009780_abnormal_chondrocyte_physiolo1.15640587
38MP0002132_abnormal_respiratory_system1.13025300
39MP0003879_abnormal_hair_cell1.08631491
40MP0000598_abnormal_liver_morphology1.05294125
41MP0003656_abnormal_erythrocyte_physiolo0.96380872
42MP0005636_abnormal_mineral_homeostasis0.94117331
43MP0005409_darkened_coat_color0.92760140
44MP0003632_abnormal_nervous_system0.92019286
45MP0005319_abnormal_enzyme/_coenzyme0.90907998
46MP0005584_abnormal_enzyme/coenzyme_acti0.90687476
47MP0000639_abnormal_adrenal_gland0.85640748
48MP0005167_abnormal_blood-brain_barrier0.85064362
49MP0009642_abnormal_blood_homeostasis0.83590174
50MP0005464_abnormal_platelet_physiology0.81759810
51MP0009643_abnormal_urine_homeostasis0.81239262
52MP0004270_analgesia0.80855567
53MP0005670_abnormal_white_adipose0.78974353
54MP0002971_abnormal_brown_adipose0.78953140
55MP0003633_abnormal_nervous_system0.71383840
56MP0003631_nervous_system_phenotype0.71323446
57MP0003121_genomic_imprinting0.70936013
58MP0004272_abnormal_basement_membrane0.69699180
59MP0002078_abnormal_glucose_homeostasis0.65677935
60MP0005084_abnormal_gallbladder_morpholo0.59422194
61MP0003950_abnormal_plasma_membrane0.58157557
62MP0002909_abnormal_adrenal_gland0.55288369
63MP0006054_spinal_hemorrhage0.53533637
64MP0003075_altered_response_to0.53263173
65MP0005376_homeostasis/metabolism_phenot0.52461268
66MP0005023_abnormal_wound_healing0.51353372
67MP0003183_abnormal_peptide_metabolism0.50685556
68MP0008469_abnormal_protein_level0.50684634
69MP0009763_increased_sensitivity_to0.49122757
70MP0005448_abnormal_energy_balance0.49103730
71MP0005646_abnormal_pituitary_gland0.49092126
72MP0003011_delayed_dark_adaptation0.48658211
73MP0003638_abnormal_response/metabolism_0.48076008
74MP0001756_abnormal_urination0.46986616
75MP0002064_seizures0.46245958
76MP0005395_other_phenotype0.45613863
77MP0002282_abnormal_trachea_morphology0.44484601
78MP0005164_abnormal_response_to0.44450577
79MP0003953_abnormal_hormone_level0.44209020
80MP0005220_abnormal_exocrine_pancreas0.43393364
81MP0002168_other_aberrant_phenotype0.42713295
82MP0005551_abnormal_eye_electrophysiolog0.42505376
83MP0005187_abnormal_penis_morphology0.39283282
84MP0009115_abnormal_fat_cell0.38987149
85MP0003878_abnormal_ear_physiology0.38863699
86MP0005377_hearing/vestibular/ear_phenot0.38863699
87MP0004883_abnormal_blood_vessel0.37972909
88MP0001270_distended_abdomen0.37963956
89MP0005257_abnormal_intraocular_pressure0.37906527
90MP0002933_joint_inflammation0.37213620
91MP0003115_abnormal_respiratory_system0.36810557
92MP0005410_abnormal_fertilization0.35756258
93MP0000003_abnormal_adipose_tissue0.34853474
94MP0005334_abnormal_fat_pad0.32888589
95MP0008569_lethality_at_weaning0.32553916
96MP0002229_neurodegeneration0.32330034
97MP0002249_abnormal_larynx_morphology0.32021453
98MP0003634_abnormal_glial_cell0.31274996
99MP0003566_abnormal_cell_adhesion0.30212650
100MP0003567_abnormal_fetal_cardiomyocyte0.29742323

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)8.73285312
2Complement deficiency (HP:0004431)7.72153029
3Hypobetalipoproteinemia (HP:0003563)7.55307269
4Abnormality of monocarboxylic acid metabolism (HP:0010996)7.05878444
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.79091437
6Joint hemorrhage (HP:0005261)6.74181524
7Abnormality of complement system (HP:0005339)5.99131598
8Abnormality of the common coagulation pathway (HP:0010990)5.55090997
9Systemic lupus erythematosus (HP:0002725)5.12413186
10Xanthomatosis (HP:0000991)5.03726363
11Glomerulonephritis (HP:0000099)5.00946229
12Conjugated hyperbilirubinemia (HP:0002908)4.77283631
13Hypolipoproteinemia (HP:0010981)4.57813301
14Spontaneous abortion (HP:0005268)4.46514678
15Hypercholesterolemia (HP:0003124)4.18094611
16Intrahepatic cholestasis (HP:0001406)4.06988880
17Hyperlipoproteinemia (HP:0010980)3.85459219
18Hemorrhage of the eye (HP:0011885)3.72859501
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.67766805
20Epidermoid cyst (HP:0200040)3.41720455
21Menorrhagia (HP:0000132)3.38355061
22Vascular calcification (HP:0004934)3.34111070
23Fat malabsorption (HP:0002630)3.29756992
24Abnormality of the intrinsic pathway (HP:0010989)3.20027234
25Gingival bleeding (HP:0000225)3.18921283
26Mitral stenosis (HP:0001718)3.15008899
27Nephritis (HP:0000123)3.06711887
28Purpura (HP:0000979)2.98477370
29Acanthocytosis (HP:0001927)2.97498183
30Cardiovascular calcification (HP:0011915)2.93702195
31Hypoalphalipoproteinemia (HP:0003233)2.88710074
32Recurrent gram-negative bacterial infections (HP:0005420)2.80585778
33Osteomalacia (HP:0002749)2.72537736
34Rickets (HP:0002748)2.70696232
35Hyperglycinemia (HP:0002154)2.60262838
36Thrombophlebitis (HP:0004418)2.57756098
37Arthropathy (HP:0003040)2.56660318
38Abnormality of pyrimidine metabolism (HP:0004353)2.53693265
39Abnormality of carpal bone ossification (HP:0006257)2.53631414
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51052322
41Myocardial infarction (HP:0001658)2.45916842
42Hypophosphatemic rickets (HP:0004912)2.44269996
43Abnormal tarsal ossification (HP:0008369)2.44112673
44Hepatocellular carcinoma (HP:0001402)2.37221552
45Generalized aminoaciduria (HP:0002909)2.27862818
46Hyperammonemia (HP:0001987)2.25686239
47Abnormality of glycine metabolism (HP:0010895)2.25198429
48Abnormality of serine family amino acid metabolism (HP:0010894)2.25198429
49Skin nodule (HP:0200036)2.23787987
50Pulmonary embolism (HP:0002204)2.19473096
51Abnormality of the Achilles tendon (HP:0005109)2.17939546
52Steatorrhea (HP:0002570)2.15200533
53Broad alveolar ridges (HP:0000187)2.13053778
54Increased serum pyruvate (HP:0003542)2.11446704
55Hyperglycinuria (HP:0003108)2.11160744
56Poikilocytosis (HP:0004447)2.10273318
57Scanning speech (HP:0002168)2.07804913
58Hypoglycemic coma (HP:0001325)2.06398593
59Small epiphyses (HP:0010585)2.05256955
60Abnormality of methionine metabolism (HP:0010901)2.04025332
61Bifid scrotum (HP:0000048)2.03964514
62Pancreatic islet-cell hyperplasia (HP:0004510)2.00613941
63Flat acetabular roof (HP:0003180)2.00486647
64Deep venous thrombosis (HP:0002625)11.3656747
65Abnormality of glycolysis (HP:0004366)1.96828081
66Enlarged kidneys (HP:0000105)1.92533064
67Alacrima (HP:0000522)1.92345340
68Abnormal gallbladder physiology (HP:0012438)1.92230494
69Cholecystitis (HP:0001082)1.92230494
70Delayed CNS myelination (HP:0002188)1.89426930
71Hepatoblastoma (HP:0002884)1.87738572
72Abnormality of the lumbar spine (HP:0100712)1.86914014
73Abnormal hand bone ossification (HP:0010660)1.85299982
74Abnormal ossification of hand bones (HP:0005921)1.83048181
75Facial shape deformation (HP:0011334)1.81576317
76Potter facies (HP:0002009)1.81576317
77Amyloidosis (HP:0011034)1.80552389
78Hydroxyprolinuria (HP:0003080)1.74603853
79Abnormality of proline metabolism (HP:0010907)1.74603853
80Retinal atrophy (HP:0001105)1.66479385
81Submucous cleft hard palate (HP:0000176)1.66018110
82Vaginal fistula (HP:0004320)1.64615125
83Broad palm (HP:0001169)1.64465707
84Fair hair (HP:0002286)1.64011172
85Joint swelling (HP:0001386)1.62199778
86Abnormal delivery (HP:0001787)1.61113798
87Epistaxis (HP:0000421)1.58515146
88Epiphyseal dysplasia (HP:0002656)1.58105969
89Hyperbilirubinemia (HP:0002904)1.58023396
90Abnormality of nucleobase metabolism (HP:0010932)1.57319952
91Abnormality of serum amino acid levels (HP:0003112)1.57318802
92Abnormality of pain sensation (HP:0010832)1.57038399
93Impaired pain sensation (HP:0007328)1.57038399
94Abnormality of the nasal septum (HP:0000419)1.56987639
95Back pain (HP:0003418)1.54370245
96Cholelithiasis (HP:0001081)1.51900667
97Hyperphosphaturia (HP:0003109)1.51482646
98Reduced antithrombin III activity (HP:0001976)1.44321925
99Mucopolysacchariduria (HP:0008155)1.43750194
100Urinary glycosaminoglycan excretion (HP:0003541)1.43750194

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR46.82780331
2FGFR34.53490107
3ICK3.34918194
4RIPK12.98993179
5FGFR22.71952957
6TYRO32.69298481
7WNK42.62979616
8CDK122.37091924
9ERN12.35338164
10NTRK32.31199282
11EPHA42.25652147
12PIK3CA2.12377241
13TRIB32.06887805
14PDGFRA1.93353106
15FGFR11.86953509
16WNK11.62680462
17RET1.49953282
18SGK4941.48585866
19SGK2231.48585866
20MAPK111.45082335
21PDPK11.44143347
22MAP3K21.37060455
23SIK21.33580674
24AKT31.33277004
25PRKAA21.29953279
26NTRK21.25461276
27SIK11.23917507
28DYRK1B1.21880096
29KSR21.17510187
30LATS21.15768833
31UHMK11.13624643
32PKN21.12813677
33PDK11.12370289
34ERBB21.09917436
35SGK31.04150903
36LATS11.01863423
37SGK10.96177063
38SGK20.93092409
39PRKACG0.92845753
40PRKCG0.87526839
41MAP3K90.86685833
42EEF2K0.86465078
43DDR20.85506623
44EIF2AK10.85127368
45TGFBR20.80604022
46IRAK30.79338091
47TYK20.74615906
48NEK90.73926920
49CSNK1E0.73675856
50RPS6KB10.71429839
51STK390.71181206
52PRKAA10.69878665
53NTRK10.69302643
54PRKCZ0.68765979
55BRSK10.65666736
56MAP2K40.65306558
57CAMKK10.65163113
58MAP3K10.64561246
59DAPK20.64298782
60MINK10.61709595
61CAMK1D0.58549385
62RPS6KA30.58093619
63CSNK1D0.56579105
64FGR0.56190578
65ALK0.55233305
66PRKG10.53111608
67MAPK100.51299414
68SRC0.51164554
69IGF1R0.50289729
70MARK10.49085219
71MAPKAPK30.46576212
72MAP3K30.45588865
73SCYL20.44883776
74MAP3K110.43475931
75MTOR0.43345109
76MET0.43143827
77CDK60.41479587
78STK380.41202836
79CDK50.41128970
80CDC42BPA0.40571072
81CDK70.39447226
82MAPKAPK50.38770730
83MAP3K50.38452025
84NEK60.38340760
85MAP3K70.37719855
86MARK20.37602983
87CDK150.37459985
88PTK60.36287392
89CAMK40.35658330
90JAK10.35355559
91PRKCB0.35010988
92PRPF4B0.34441926
93JAK20.34400924
94BCR0.34254714
95PTK20.33409129
96EPHA30.32965725
97CAMKK20.32835396
98SMG10.32634747
99CSF1R0.32516110
100FYN0.31518034

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.71962740
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.34943920
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31911631
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.31381421
5Caffeine metabolism_Homo sapiens_hsa002322.91071690
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.77822845
7Arginine biosynthesis_Homo sapiens_hsa002202.70779324
8Retinol metabolism_Homo sapiens_hsa008302.68674010
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.55969912
10Fatty acid degradation_Homo sapiens_hsa000712.48884920
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47448168
12Chemical carcinogenesis_Homo sapiens_hsa052042.37110108
13Histidine metabolism_Homo sapiens_hsa003402.34697673
14Phenylalanine metabolism_Homo sapiens_hsa003602.34276901
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.33474496
16Steroid hormone biosynthesis_Homo sapiens_hsa001402.22938807
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.11265021
18Tyrosine metabolism_Homo sapiens_hsa003502.03154088
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.99478543
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98543464
21Bile secretion_Homo sapiens_hsa049761.95919873
22Butanoate metabolism_Homo sapiens_hsa006501.86545470
23PPAR signaling pathway_Homo sapiens_hsa033201.77757573
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72543179
25Fat digestion and absorption_Homo sapiens_hsa049751.63801658
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.63034815
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.61144035
28Starch and sucrose metabolism_Homo sapiens_hsa005001.60185068
29Vitamin B6 metabolism_Homo sapiens_hsa007501.59358902
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50540429
31Tryptophan metabolism_Homo sapiens_hsa003801.46674627
32Fatty acid metabolism_Homo sapiens_hsa012121.38987854
33Staphylococcus aureus infection_Homo sapiens_hsa051501.38750139
34Arginine and proline metabolism_Homo sapiens_hsa003301.32124081
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30902016
36Peroxisome_Homo sapiens_hsa041461.25240451
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22984946
38beta-Alanine metabolism_Homo sapiens_hsa004101.20379056
39Biosynthesis of amino acids_Homo sapiens_hsa012301.17998833
40Steroid biosynthesis_Homo sapiens_hsa001001.17179632
41ABC transporters_Homo sapiens_hsa020101.13598828
42Prion diseases_Homo sapiens_hsa050201.11733911
43Pyruvate metabolism_Homo sapiens_hsa006200.99498992
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.98741729
45Propanoate metabolism_Homo sapiens_hsa006400.98224925
46Linoleic acid metabolism_Homo sapiens_hsa005910.97793234
47Fatty acid biosynthesis_Homo sapiens_hsa000610.97124608
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93166306
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91765256
50Carbon metabolism_Homo sapiens_hsa012000.90860328
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88463089
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.84672381
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82744083
54Vitamin digestion and absorption_Homo sapiens_hsa049770.80982515
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79606383
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78790418
57Other glycan degradation_Homo sapiens_hsa005110.70170942
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.67858699
59Lysine degradation_Homo sapiens_hsa003100.64395308
60One carbon pool by folate_Homo sapiens_hsa006700.59547666
61Arachidonic acid metabolism_Homo sapiens_hsa005900.59446529
62Glycerolipid metabolism_Homo sapiens_hsa005610.48993180
63Fructose and mannose metabolism_Homo sapiens_hsa000510.45671927
64Fatty acid elongation_Homo sapiens_hsa000620.41278420
65Pertussis_Homo sapiens_hsa051330.38389811
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37537144
67Metabolic pathways_Homo sapiens_hsa011000.36876751
68Glucagon signaling pathway_Homo sapiens_hsa049220.31995534
69Sulfur relay system_Homo sapiens_hsa041220.31001716
70Insulin resistance_Homo sapiens_hsa049310.30038755
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.29482205
72Renin-angiotensin system_Homo sapiens_hsa046140.29177639
73Thyroid hormone synthesis_Homo sapiens_hsa049180.29045396
74N-Glycan biosynthesis_Homo sapiens_hsa005100.23774961
75Nitrogen metabolism_Homo sapiens_hsa009100.19515830
76Galactose metabolism_Homo sapiens_hsa000520.19465225
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15602646
78Pentose phosphate pathway_Homo sapiens_hsa000300.14488893
79Sulfur metabolism_Homo sapiens_hsa009200.14403309
80AMPK signaling pathway_Homo sapiens_hsa041520.11844475
81Sphingolipid metabolism_Homo sapiens_hsa006000.09953690
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09216369
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08031887
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.07818012
85Glutathione metabolism_Homo sapiens_hsa004800.05343466
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04658484
87Insulin signaling pathway_Homo sapiens_hsa049100.01456546
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00125599
89Ether lipid metabolism_Homo sapiens_hsa00565-0.1317748
90Selenocompound metabolism_Homo sapiens_hsa00450-0.1273148
91Amoebiasis_Homo sapiens_hsa05146-0.1233088
92Long-term potentiation_Homo sapiens_hsa04720-0.1148739
93Circadian rhythm_Homo sapiens_hsa04710-0.0952851
94Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0900552
95African trypanosomiasis_Homo sapiens_hsa05143-0.0755208
96GABAergic synapse_Homo sapiens_hsa04727-0.0749352
97Folate biosynthesis_Homo sapiens_hsa00790-0.0620105
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0590738
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0475323
100ECM-receptor interaction_Homo sapiens_hsa04512-0.0335832

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