TFAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.37758000
2DNA strand elongation involved in DNA replication (GO:0006271)4.37661415
3nucleobase biosynthetic process (GO:0046112)4.30696449
4folic acid-containing compound biosynthetic process (GO:0009396)4.22034618
5mitotic sister chromatid segregation (GO:0000070)4.21304624
6mitotic sister chromatid cohesion (GO:0007064)4.21159588
7ribosomal small subunit assembly (GO:0000028)4.21033948
8DNA replication initiation (GO:0006270)4.19805366
9DNA strand elongation (GO:0022616)4.14189393
10telomere maintenance via semi-conservative replication (GO:0032201)4.09448667
11sister chromatid segregation (GO:0000819)4.08137621
12purine nucleobase biosynthetic process (GO:0009113)4.07623967
13IMP biosynthetic process (GO:0006188)4.03783595
14maturation of SSU-rRNA (GO:0030490)3.94288232
15formation of translation preinitiation complex (GO:0001731)3.90165245
16pore complex assembly (GO:0046931)3.86638841
17mitotic metaphase plate congression (GO:0007080)3.75801191
18viral transcription (GO:0019083)3.71542607
19ribosomal large subunit biogenesis (GO:0042273)3.70994378
20translational termination (GO:0006415)3.68450024
21telomere maintenance via recombination (GO:0000722)3.64298747
22regulation of centriole replication (GO:0046599)3.64069796
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.61122358
24chromatin remodeling at centromere (GO:0031055)3.60252109
25IMP metabolic process (GO:0046040)3.57438605
26mitotic recombination (GO:0006312)3.55656404
27CENP-A containing nucleosome assembly (GO:0034080)3.53996439
28DNA deamination (GO:0045006)3.53392060
29glycine metabolic process (GO:0006544)3.53391589
30translational elongation (GO:0006414)3.53342496
31DNA replication-dependent nucleosome organization (GO:0034723)3.52415022
32DNA replication-dependent nucleosome assembly (GO:0006335)3.52415022
33non-recombinational repair (GO:0000726)3.50795627
34double-strand break repair via nonhomologous end joining (GO:0006303)3.50795627
35DNA ligation (GO:0006266)3.47654097
36protein localization to kinetochore (GO:0034501)3.47300851
37metaphase plate congression (GO:0051310)3.46517662
38DNA replication checkpoint (GO:0000076)3.46443280
39nuclear pore organization (GO:0006999)3.45799158
40spindle checkpoint (GO:0031577)3.45634452
41negative regulation of chromosome segregation (GO:0051985)3.45356138
42ribosome biogenesis (GO:0042254)3.44694127
43DNA topological change (GO:0006265)3.44157506
44negative regulation of mitotic sister chromatid separation (GO:2000816)3.43804128
45negative regulation of sister chromatid segregation (GO:0033046)3.43804128
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.43804128
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.43804128
48regulation of DNA endoreduplication (GO:0032875)3.41206171
49mitotic nuclear envelope disassembly (GO:0007077)3.40581298
50ribonucleoprotein complex biogenesis (GO:0022613)3.38853866
51mitotic spindle checkpoint (GO:0071174)3.38511891
52telomere maintenance via telomere lengthening (GO:0010833)3.38498785
53regulation of chromosome segregation (GO:0051983)3.32426508
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28917989
55regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28917989
56rRNA modification (GO:0000154)3.28692133
57translational initiation (GO:0006413)3.27305536
58histone exchange (GO:0043486)3.25279245
59mitotic spindle assembly checkpoint (GO:0007094)3.23324390
60ribosome assembly (GO:0042255)3.22548801
61folic acid metabolic process (GO:0046655)3.22375430
62DNA replication-independent nucleosome assembly (GO:0006336)3.21480452
63DNA replication-independent nucleosome organization (GO:0034724)3.21480452
64spindle assembly checkpoint (GO:0071173)3.21418376
65negative regulation of DNA-dependent DNA replication (GO:2000104)3.19418676
66DNA double-strand break processing (GO:0000729)3.19277189
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.18988166
68nuclear pore complex assembly (GO:0051292)3.18381664
69tetrahydrofolate metabolic process (GO:0046653)3.18084832
70establishment of viral latency (GO:0019043)3.16758742
71regulation of sister chromatid segregation (GO:0033045)3.15354516
72regulation of mitotic sister chromatid separation (GO:0010965)3.15354516
73regulation of mitotic sister chromatid segregation (GO:0033047)3.15354516
74regulation of centrosome cycle (GO:0046605)3.15196612
75kinetochore assembly (GO:0051382)3.14782190
76nuclear envelope disassembly (GO:0051081)3.12865964
77membrane disassembly (GO:0030397)3.12865964
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12770679
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12212217
80spliceosomal snRNP assembly (GO:0000387)3.11969684
81pteridine-containing compound biosynthetic process (GO:0042559)3.11778381
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11074419
83negative regulation of RNA splicing (GO:0033119)3.10865821
84ribosomal small subunit biogenesis (GO:0042274)3.10748949
85termination of RNA polymerase II transcription (GO:0006369)3.10726079
86pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.09626656
87serine family amino acid biosynthetic process (GO:0009070)3.08168283
88mitotic G2/M transition checkpoint (GO:0044818)3.08159977
89protein complex localization (GO:0031503)3.07513924
90positive regulation of chromosome segregation (GO:0051984)3.06810696
91establishment of integrated proviral latency (GO:0075713)3.06801918
92regulation of translational fidelity (GO:0006450)3.05188187
93chaperone-mediated protein complex assembly (GO:0051131)3.04809803
94negative regulation of mRNA processing (GO:0050686)3.04269639
95maturation of 5.8S rRNA (GO:0000460)3.04037988
96cotranslational protein targeting to membrane (GO:0006613)3.02651911
97chromatin assembly or disassembly (GO:0006333)3.02374713
98chromosome segregation (GO:0007059)3.01698015
99protein targeting to ER (GO:0045047)3.01282107
100establishment of chromosome localization (GO:0051303)3.01016026
101rRNA processing (GO:0006364)3.00354469
102regulation of mitochondrial translation (GO:0070129)2.99231317
103DNA damage response, detection of DNA damage (GO:0042769)2.99108742
104regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98256597
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.97205621
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97205621
107protein localization to chromosome, centromeric region (GO:0071459)2.97112832
108pseudouridine synthesis (GO:0001522)2.96285695
109kinetochore organization (GO:0051383)2.94785925
110rRNA methylation (GO:0031167)2.89624468
111rRNA metabolic process (GO:0016072)2.89566294
112cellular protein complex disassembly (GO:0043624)2.87603119
113pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.86820559
114regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86228977
115protein localization to endoplasmic reticulum (GO:0070972)2.85572494
116transcription-coupled nucleotide-excision repair (GO:0006283)2.84605970
117establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83744931
118viral life cycle (GO:0019058)2.82151222
119DNA duplex unwinding (GO:0032508)2.80224973
120spliceosomal complex assembly (GO:0000245)2.79924350
121proteasome assembly (GO:0043248)2.79641571
122DNA geometric change (GO:0032392)2.79086819
123L-serine metabolic process (GO:0006563)2.77437557
124translation (GO:0006412)2.75762040
125regulation of spindle organization (GO:0090224)2.73724998
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72446481
127mitotic chromosome condensation (GO:0007076)2.72108251
128folic acid-containing compound metabolic process (GO:0006760)2.70508338
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70295522
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69784577
131protein complex disassembly (GO:0043241)2.68996032
132mitochondrial DNA replication (GO:0006264)2.68731421
133deoxyribose phosphate biosynthetic process (GO:0046385)2.68709746
1342-deoxyribonucleotide biosynthetic process (GO:0009265)2.68709746
135telomere maintenance (GO:0000723)2.67615316
136regulation of helicase activity (GO:0051095)2.67397211
137telomere organization (GO:0032200)2.66550033
138pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.66435895
139UMP metabolic process (GO:0046049)2.66435895
140pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.66435895
141UMP biosynthetic process (GO:0006222)2.66435895
142deoxyribonucleotide biosynthetic process (GO:0009263)2.66051698
143regulation of histone H3-K9 methylation (GO:0051570)2.65174453
144one-carbon metabolic process (GO:0006730)2.64614176
145negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64594479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14959337
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.45823333
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69649454
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51760983
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.41063480
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11319891
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94226157
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90404701
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87214838
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.83934665
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83371953
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.75164868
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64742441
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62687518
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.58048761
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39367606
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39033111
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35846794
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31035328
20XRN2_22483619_ChIP-Seq_HELA_Human2.22996701
21VDR_23849224_ChIP-Seq_CD4+_Human2.17244979
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16216842
23AR_21909140_ChIP-Seq_LNCAP_Human2.13250501
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.04864091
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02793140
26FOXP3_21729870_ChIP-Seq_TREG_Human2.00058898
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99895030
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.95322182
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95089057
30DCP1A_22483619_ChIP-Seq_HELA_Human1.92014325
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91714198
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90497916
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86402169
34* GABP_19822575_ChIP-Seq_HepG2_Human1.81969718
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78849624
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71887733
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70659232
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66861454
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64510595
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62340853
41* TTF2_22483619_ChIP-Seq_HELA_Human1.61987796
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61604006
43* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59024377
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57276990
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56587662
46ELK1_19687146_ChIP-ChIP_HELA_Human1.56450568
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55422688
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54174283
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52586095
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51510000
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50505300
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44505722
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44372268
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.44018442
55* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43010695
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.38039130
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37804090
58MYC_22102868_ChIP-Seq_BL_Human1.37326068
59CIITA_25753668_ChIP-Seq_RAJI_Human1.37135595
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36249965
61KDM5A_27292631_Chip-Seq_BREAST_Human1.35978736
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34415356
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33667716
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31425699
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.28599052
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25713964
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19703640
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18032646
69EWS_26573619_Chip-Seq_HEK293_Human1.15845594
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15829133
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15424444
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15229453
73* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15103114
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14336442
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14298750
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14066285
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.13524349
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11999764
79MYC_18940864_ChIP-ChIP_HL60_Human1.11080959
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10717193
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10356353
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09921442
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.05898049
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04203099
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.02554369
86FUS_26573619_Chip-Seq_HEK293_Human1.02113319
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.01526956
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.01399521
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00933489
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99975481
91* RXR_22158963_ChIP-Seq_LIVER_Mouse0.99494446
92POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99198565
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97071139
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95594184
95* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95104880
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93978313
97TFEB_21752829_ChIP-Seq_HELA_Human0.92851136
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91186176
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91058127
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88045672
101* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87109168
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.86597392
103SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86544132
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85971148
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82902974
106CHD1_26751641_Chip-Seq_LNCaP_Human0.81963730
107TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80407843
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79687034
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78440695
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77366178
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77219757
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76832039
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75852301
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75286113
115ELK1_22589737_ChIP-Seq_MCF10A_Human0.75164273
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.70365320
117ELF5_23300383_ChIP-Seq_T47D_Human0.69070570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41356870
2MP0003806_abnormal_nucleotide_metabolis4.30058043
3MP0010094_abnormal_chromosome_stability4.10645662
4MP0004957_abnormal_blastocyst_morpholog3.91677526
5MP0002139_abnormal_hepatobiliary_system3.75170082
6MP0003111_abnormal_nucleus_morphology3.51324039
7MP0003077_abnormal_cell_cycle3.31291916
8MP0008057_abnormal_DNA_replication3.05918056
9MP0008058_abnormal_DNA_repair2.92657098
10MP0005360_urolithiasis2.89294395
11MP0005085_abnormal_gallbladder_physiolo2.58572174
12MP0003941_abnormal_skin_development2.58397357
13MP0008007_abnormal_cellular_replicative2.57577177
14MP0005365_abnormal_bile_salt2.48436965
15MP0001730_embryonic_growth_arrest2.23906737
16MP0008932_abnormal_embryonic_tissue2.08549697
17MP0003123_paternal_imprinting2.05555861
18MP0008875_abnormal_xenobiotic_pharmacok1.87859921
19MP0000350_abnormal_cell_proliferation1.78726755
20MP0010352_gastrointestinal_tract_polyps1.78101701
21* MP0006036_abnormal_mitochondrial_physio1.77228832
22MP0002396_abnormal_hematopoietic_system1.71551310
23MP0003186_abnormal_redox_activity1.62113850
24MP0002138_abnormal_hepatobiliary_system1.56630436
25MP0001672_abnormal_embryogenesis/_devel1.55843916
26MP0005380_embryogenesis_phenotype1.55843916
27MP0001697_abnormal_embryo_size1.54740737
28MP0003252_abnormal_bile_duct1.50712560
29MP0003937_abnormal_limbs/digits/tail_de1.50376279
30MP0003984_embryonic_growth_retardation1.43851628
31MP0008877_abnormal_DNA_methylation1.43819632
32MP0003567_abnormal_fetal_cardiomyocyte1.42225132
33MP0002088_abnormal_embryonic_growth/wei1.42077370
34* MP0002080_prenatal_lethality1.41046468
35MP0009697_abnormal_copulation1.40244679
36MP0002132_abnormal_respiratory_system1.39122323
37MP0009379_abnormal_foot_pigmentation1.33857107
38MP0001764_abnormal_homeostasis1.27845920
39MP0003718_maternal_effect1.27434914
40MP0010307_abnormal_tumor_latency1.26025954
41MP0000490_abnormal_crypts_of1.24988895
42MP0002086_abnormal_extraembryonic_tissu1.24921859
43MP0004197_abnormal_fetal_growth/weight/1.24423592
44MP0002938_white_spotting1.24044430
45MP0005332_abnormal_amino_acid1.23851819
46* MP0006035_abnormal_mitochondrial_morpho1.22803866
47MP0002009_preneoplasia1.21521517
48MP0003890_abnormal_embryonic-extraembry1.20608723
49MP0002019_abnormal_tumor_incidence1.20515476
50MP0003786_premature_aging1.19410106
51MP0000537_abnormal_urethra_morphology1.18833438
52MP0004808_abnormal_hematopoietic_stem1.18228145
53MP0001929_abnormal_gametogenesis1.17643409
54* MP0000313_abnormal_cell_death1.17547370
55MP0002697_abnormal_eye_size1.16809461
56* MP0002085_abnormal_embryonic_tissue1.16214539
57MP0009672_abnormal_birth_weight1.16103973
58MP0002084_abnormal_developmental_patter1.15566360
59MP0002210_abnormal_sex_determination1.13990645
60MP0001286_abnormal_eye_development1.13430017
61MP0003763_abnormal_thymus_physiology1.12882486
62MP0009053_abnormal_anal_canal1.12678250
63MP0001293_anophthalmia1.09943582
64MP0000598_abnormal_liver_morphology1.03819667
65MP0000609_abnormal_liver_physiology1.02620954
66MP0010329_abnormal_lipoprotein_level1.02543127
67MP0001145_abnormal_male_reproductive1.01932360
68MP0005266_abnormal_metabolism1.01545901
69MP0002111_abnormal_tail_morphology1.00821772
70MP0003705_abnormal_hypodermis_morpholog0.99941997
71MP0005083_abnormal_biliary_tract0.99805755
72* MP0005319_abnormal_enzyme/_coenzyme0.99529525
73MP0005410_abnormal_fertilization0.99218832
74MP0004133_heterotaxia0.98770561
75MP0009703_decreased_birth_body0.97097921
76MP0001529_abnormal_vocalization0.95396166
77MP0002877_abnormal_melanocyte_morpholog0.91404794
78MP0002160_abnormal_reproductive_system0.90760114
79MP0006072_abnormal_retinal_apoptosis0.90319709
80MP0005408_hypopigmentation0.90228472
81* MP0000358_abnormal_cell_content/0.88268662
82MP0000653_abnormal_sex_gland0.88022170
83MP0002796_impaired_skin_barrier0.87959249
84MP0000703_abnormal_thymus_morphology0.86807293
85MP0000689_abnormal_spleen_morphology0.85432142
86MP0003119_abnormal_digestive_system0.85044422
87MP0006054_spinal_hemorrhage0.83258980
88MP0003121_genomic_imprinting0.83073816
89MP0005397_hematopoietic_system_phenotyp0.81013201
90MP0001545_abnormal_hematopoietic_system0.81013201
91MP0002722_abnormal_immune_system0.80991317
92MP0010234_abnormal_vibrissa_follicle0.80608671
93MP0005501_abnormal_skin_physiology0.80368791
94MP0002233_abnormal_nose_morphology0.80213257
95MP0009840_abnormal_foam_cell0.79513355
96MP0010030_abnormal_orbit_morphology0.78918437
97MP0002092_abnormal_eye_morphology0.78644845
98MP0006292_abnormal_olfactory_placode0.78460737
99MP0002398_abnormal_bone_marrow0.77698811
100MP0009333_abnormal_splenocyte_physiolog0.75584120
101MP0001915_intracranial_hemorrhage0.75488052
102MP0004185_abnormal_adipocyte_glucose0.75086964
103MP0001727_abnormal_embryo_implantation0.74778300
104MP0002102_abnormal_ear_morphology0.73849937
105MP0001666_abnormal_nutrient_absorption0.73596963
106MP0001188_hyperpigmentation0.72128113
107MP0000647_abnormal_sebaceous_gland0.71561244
108MP0001853_heart_inflammation0.71230233
109MP0003136_yellow_coat_color0.69723755
110MP0003698_abnormal_male_reproductive0.69651567
111* MP0003221_abnormal_cardiomyocyte_apopto0.69459531
112MP0005389_reproductive_system_phenotype0.68988431
113MP0001119_abnormal_female_reproductive0.68657263
114MP0002269_muscular_atrophy0.68448853
115MP0000428_abnormal_craniofacial_morphol0.67618175
116MP0003861_abnormal_nervous_system0.66447874
117MP0003943_abnormal_hepatobiliary_system0.65253887
118MP0005076_abnormal_cell_differentiation0.64865129
119MP0008995_early_reproductive_senescence0.64299897
120MP0005670_abnormal_white_adipose0.64158606
121MP0001661_extended_life_span0.62913045
122* MP0005384_cellular_phenotype0.62527977
123MP0002429_abnormal_blood_cell0.62364636
124MP0000477_abnormal_intestine_morphology0.62290824
125MP0005395_other_phenotype0.61936886
126MP0001346_abnormal_lacrimal_gland0.61800820
127MP0003755_abnormal_palate_morphology0.60714946
128MP0005376_homeostasis/metabolism_phenot0.60363426
129MP0010368_abnormal_lymphatic_system0.59782509
130MP0003315_abnormal_perineum_morphology0.59263894
131MP0005187_abnormal_penis_morphology0.59214394
132MP0005220_abnormal_exocrine_pancreas0.58974287
133MP0001881_abnormal_mammary_gland0.58623222
134MP0002163_abnormal_gland_morphology0.56983597
135MP0009643_abnormal_urine_homeostasis0.56484422
136MP0004019_abnormal_vitamin_homeostasis0.56400338
137MP0003699_abnormal_female_reproductive0.55941335
138MP0004264_abnormal_extraembryonic_tissu0.55836028
139MP0005391_vision/eye_phenotype0.55805896
140MP0008789_abnormal_olfactory_epithelium0.55143352
141MP0003935_abnormal_craniofacial_develop0.54776412
142MP0002161_abnormal_fertility/fecundity0.53795264
143MP0000049_abnormal_middle_ear0.53730293

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.94730250
2Birth length less than 3rd percentile (HP:0003561)4.37728508
3Abnormality of cells of the erythroid lineage (HP:0012130)4.22641591
4Abnormal number of erythroid precursors (HP:0012131)4.05032515
5Hypobetalipoproteinemia (HP:0003563)3.86314322
6Reticulocytopenia (HP:0001896)3.84684629
7Abnormality of pyrimidine metabolism (HP:0004353)3.64863370
8Oral leukoplakia (HP:0002745)3.58813282
9Hyperglycinemia (HP:0002154)3.47305051
10Volvulus (HP:0002580)3.37126859
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.30959007
12Colon cancer (HP:0003003)3.09638310
13Intrahepatic cholestasis (HP:0001406)3.05327405
14Breast hypoplasia (HP:0003187)3.04495292
15Hyperglycinuria (HP:0003108)3.03955665
16Nephroblastoma (Wilms tumor) (HP:0002667)2.98462039
17Increased hepatocellular lipid droplets (HP:0006565)2.88626508
18Degeneration of anterior horn cells (HP:0002398)2.88475069
19Abnormality of the anterior horn cell (HP:0006802)2.88475069
20Macrocytic anemia (HP:0001972)2.87819408
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85833579
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84207084
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84207084
24Embryonal renal neoplasm (HP:0011794)2.83864466
25Medulloblastoma (HP:0002885)2.80493695
26Abnormality of glycine metabolism (HP:0010895)2.78742329
27Abnormality of serine family amino acid metabolism (HP:0010894)2.78742329
28Aplastic anemia (HP:0001915)2.77168497
29Abnormality of the labia minora (HP:0012880)2.73928601
30Acute necrotizing encephalopathy (HP:0006965)2.73087877
31Microvesicular hepatic steatosis (HP:0001414)2.69564010
32Rhabdomyosarcoma (HP:0002859)2.66005311
33Acute encephalopathy (HP:0006846)2.64237027
34Multiple enchondromatosis (HP:0005701)2.64196143
35Impulsivity (HP:0100710)2.63703277
36Hyperammonemia (HP:0001987)2.61812596
37Abnormality of serum amino acid levels (HP:0003112)2.56376315
38Lipid accumulation in hepatocytes (HP:0006561)2.55728677
39Abnormality of the duodenum (HP:0002246)2.55286813
40Hypoglycemic coma (HP:0001325)2.55015537
41Increased nuchal translucency (HP:0010880)2.54891651
42Ependymoma (HP:0002888)2.54059727
43Abnormal mitochondria in muscle tissue (HP:0008316)2.47888487
44Cortical dysplasia (HP:0002539)2.44783424
45Increased serum lactate (HP:0002151)2.42848807
46Pallor (HP:0000980)2.42355987
47Absent thumb (HP:0009777)2.42315905
48Abnormality of chromosome stability (HP:0003220)2.42161119
49Progressive muscle weakness (HP:0003323)2.40443758
50Selective tooth agenesis (HP:0001592)2.38629979
51Nausea (HP:0002018)2.37565379
52Abnormality of methionine metabolism (HP:0010901)2.35872087
53Absent radius (HP:0003974)2.34046907
54Abnormality of glycolysis (HP:0004366)2.32263042
55Increased serum pyruvate (HP:0003542)2.32263042
56Megaloblastic anemia (HP:0001889)2.31969889
57Triphalangeal thumb (HP:0001199)2.30491252
58Patellar aplasia (HP:0006443)2.25435691
59Pancreatic islet-cell hyperplasia (HP:0004510)2.23252394
60Abnormality of the carotid arteries (HP:0005344)2.21867256
61Abnormality of the preputium (HP:0100587)2.21457592
62Progressive macrocephaly (HP:0004481)2.20089529
63Sloping forehead (HP:0000340)2.19319997
64Horseshoe kidney (HP:0000085)2.18730591
65Abnormal lung lobation (HP:0002101)2.18261565
66Ectopic kidney (HP:0000086)2.16277162
67Absent forearm bone (HP:0003953)2.16191571
68Aplasia involving forearm bones (HP:0009822)2.16191571
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16117688
70Meckel diverticulum (HP:0002245)2.15533569
71Aplasia/Hypoplasia of the patella (HP:0006498)2.15119450
72Supernumerary spleens (HP:0009799)2.14339362
73Rhabdomyolysis (HP:0003201)2.13704195
74Microretrognathia (HP:0000308)2.13287881
75Cellular immunodeficiency (HP:0005374)2.13149368
76Myelodysplasia (HP:0002863)2.12538784
77Hypolipoproteinemia (HP:0010981)2.12030974
78Pancytopenia (HP:0001876)2.11663593
79Cerebral edema (HP:0002181)2.11325003
80Carpal bone hypoplasia (HP:0001498)2.11182832
81Spastic diplegia (HP:0001264)2.09415176
82Dicarboxylic aciduria (HP:0003215)2.06812359
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06812359
84Ragged-red muscle fibers (HP:0003200)2.06493784
85Hepatic necrosis (HP:0002605)2.06481156
86Abnormality of reticulocytes (HP:0004312)2.05756193
87Clubbing of toes (HP:0100760)2.05716828
88Mitochondrial inheritance (HP:0001427)2.04641089
89Choanal atresia (HP:0000453)2.02877880
90Progressive external ophthalmoplegia (HP:0000590)2.00813963
91Reduced antithrombin III activity (HP:0001976)2.00109090
92Stenosis of the external auditory canal (HP:0000402)1.99652268
93Abnormality of sulfur amino acid metabolism (HP:0004339)1.99234467
94Lethargy (HP:0001254)1.98919661
95Proximal placement of thumb (HP:0009623)1.98181848
96Glioma (HP:0009733)1.97540599
97Chromsome breakage (HP:0040012)1.97087883
98Abnormality of the ileum (HP:0001549)1.97075352
99Deep venous thrombosis (HP:0002625)1.96579828
100Cafe-au-lait spot (HP:0000957)1.95027158
101Neoplasm of the pancreas (HP:0002894)1.94632249
102Abnormality of alanine metabolism (HP:0010916)1.94378508
103Hyperalaninemia (HP:0003348)1.94378508
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94378508
105Abnormality of the heme biosynthetic pathway (HP:0010472)1.93698819
106Facial cleft (HP:0002006)1.93519914
107Abnormality of homocysteine metabolism (HP:0010919)1.92753041
108Homocystinuria (HP:0002156)1.92753041
109Thrombocytosis (HP:0001894)1.92661125
11011 pairs of ribs (HP:0000878)1.91755540
111Lactic acidosis (HP:0003128)1.91154110
112Delayed CNS myelination (HP:0002188)1.91027604
113Respiratory difficulties (HP:0002880)1.90726030
114Ketosis (HP:0001946)1.88756138
115Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88204996
116Deviation of the thumb (HP:0009603)1.88195185
117Overlapping toe (HP:0001845)1.87782074
118Neoplasm of the colon (HP:0100273)1.87266152
119Rough bone trabeculation (HP:0100670)1.86354782
120Type I transferrin isoform profile (HP:0003642)1.85510684
121Abnormality of nucleobase metabolism (HP:0010932)1.84567767
122Abnormal spermatogenesis (HP:0008669)1.83514248
123Angiofibromas (HP:0010615)1.83434491
124Adenoma sebaceum (HP:0009720)1.83434491
125Agnosia (HP:0010524)1.83240613
126Leukodystrophy (HP:0002415)1.83175537
127Neoplasm of striated muscle (HP:0009728)1.82068455
128Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80614539
129Increased CSF lactate (HP:0002490)1.79927851
130Small intestinal stenosis (HP:0012848)1.79824401
131Duodenal stenosis (HP:0100867)1.79824401
132Ovarian neoplasm (HP:0100615)1.79440052
133Premature graying of hair (HP:0002216)1.79213418
134Abnormality of fatty-acid metabolism (HP:0004359)1.79138373
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.79000811
136Sparse eyelashes (HP:0000653)1.78797165
137Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77701949
138Hepatocellular necrosis (HP:0001404)1.77125330
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76715179
140Hyperbilirubinemia (HP:0002904)1.76503928
141Bone marrow hypocellularity (HP:0005528)1.76243154
142Short middle phalanx of the 5th finger (HP:0004220)1.71812134
143Abnormal umbilical cord blood vessels (HP:0011403)1.70335705
144Single umbilical artery (HP:0001195)1.70335705
145Abnormality of the fetal cardiovascular system (HP:0010948)1.70335705
146Septate vagina (HP:0001153)1.69660949
147Neoplasm of the adrenal gland (HP:0100631)1.69259307
148Embryonal neoplasm (HP:0002898)1.68163534
149Abnormality of the pons (HP:0007361)1.65682134
150Short thumb (HP:0009778)1.64144945
151Hypoplasia of the pons (HP:0012110)1.63956591
152Duplicated collecting system (HP:0000081)1.63696383
153Postnatal microcephaly (HP:0005484)1.63096554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.75922041
2CDC73.74487674
3WEE13.57364890
4EIF2AK13.55880162
5PBK2.83210452
6BCKDK2.64861329
7PDK32.60625117
8PDK42.60625117
9NME22.44422712
10NEK12.43043451
11NEK22.37213591
12STK162.25447130
13VRK22.22003096
14MST42.15014152
15TTK2.13703833
16SRPK12.12758626
17EIF2AK32.06047718
18TAF12.04944049
19TSSK62.03864128
20VRK11.99667610
21PASK1.93907503
22MKNK11.93525133
23PLK41.86822480
24PLK11.83093749
25ACVR1B1.78305626
26PDK21.77143876
27PKN21.67819182
28MKNK21.59147954
29TRIM281.57563677
30BRD41.55962113
31BRSK21.55429913
32TLK11.54797180
33ATR1.54107552
34MAP2K31.53275427
35RPS6KB21.52171080
36DYRK31.50848216
37AURKB1.47606521
38RPS6KA41.47248864
39PLK31.46586639
40TGFBR11.35104128
41CDK71.34528969
42CDK41.34047028
43MAP3K81.31323672
44EEF2K1.29527003
45PNCK1.27709168
46FLT31.26310372
47CDK121.22565361
48ZAK1.21787239
49CHEK21.12294977
50TESK21.10228910
51SCYL21.10094857
52TAOK21.07104960
53MAP3K31.05546777
54STK101.04174768
55AURKA0.99064998
56CHEK10.97917720
57MAP3K100.97737494
58CCNB10.95815560
59STK40.94225747
60MAP4K10.90710360
61TNIK0.88315019
62MAP2K60.84108511
63BRSK10.83010559
64ATM0.82122942
65KDR0.81869912
66NEK90.80549681
67NME10.79781805
68PAK40.76583381
69ERBB30.75989183
70ALK0.74379379
71CSNK2A20.72251548
72CSNK2A10.71452035
73CDK60.70070672
74ERBB40.69896169
75GRK60.68677550
76CSNK1G10.68231827
77* CDK20.66743513
78BMPR1B0.65767978
79PIM10.64796105
80SMG10.64391303
81TESK10.63898374
82BCR0.63363484
83MAP3K110.62493286
84MAP3K120.60618080
85CDK30.57800907
86STK38L0.55192147
87STK240.53823040
88EIF2AK20.52434651
89MAPK110.52170084
90FGFR10.49985927
91EPHA20.49948796
92CSNK1G30.49100182
93BRAF0.48670288
94MAPKAPK30.48165241
95LRRK20.47106301
96NLK0.46404356
97CDK10.46301098
98LATS10.46201089
99YES10.44829332
100RAF10.43233881
101MAP3K50.41969502
102OBSCN0.41619922
103CSNK1A1L0.41406592
104PLK20.41185165
105CDK80.40187398
106AKT20.38583506
107LATS20.38287316
108MELK0.38209779
109CDK90.38076623
110CSNK1G20.38056385
111TEC0.36001878
112STK30.33406988
113PAK10.32393407
114PRKCI0.31968577
115RPS6KB10.31223390
116NUAK10.30348125
117BTK0.29527305
118RPS6KA50.28279069
119STK390.28111323
120CLK10.25817709
121CSNK1E0.25768567
122PRKDC0.23334919
123CSF1R0.22694101
124WNK30.22527624
125TRIB30.22014322
126ZAP700.20598411
127OXSR10.20585948
128DMPK0.20292672
129DAPK10.19208026
130DYRK20.18296537

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.12366197
2Mismatch repair_Homo sapiens_hsa034303.51847532
3Ribosome_Homo sapiens_hsa030103.07016557
4One carbon pool by folate_Homo sapiens_hsa006702.94648818
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82796503
6Proteasome_Homo sapiens_hsa030502.61874545
7Spliceosome_Homo sapiens_hsa030402.61458101
8RNA polymerase_Homo sapiens_hsa030202.51226960
9RNA transport_Homo sapiens_hsa030132.38701607
10Base excision repair_Homo sapiens_hsa034102.34491718
11Nucleotide excision repair_Homo sapiens_hsa034202.22501008
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21201879
13Pyrimidine metabolism_Homo sapiens_hsa002402.19894475
14Homologous recombination_Homo sapiens_hsa034402.16954756
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93312897
16Cell cycle_Homo sapiens_hsa041101.82054957
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.80626350
18Selenocompound metabolism_Homo sapiens_hsa004501.78908285
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78332274
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70314768
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.70311324
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.66784248
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60253191
24Biosynthesis of amino acids_Homo sapiens_hsa012301.55006121
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54827115
26Fanconi anemia pathway_Homo sapiens_hsa034601.52912082
27Carbon metabolism_Homo sapiens_hsa012001.50092279
28RNA degradation_Homo sapiens_hsa030181.46764396
29Propanoate metabolism_Homo sapiens_hsa006401.46691328
30Non-homologous end-joining_Homo sapiens_hsa034501.42524495
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38975923
32Folate biosynthesis_Homo sapiens_hsa007901.38302472
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36372926
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35984923
35Sulfur relay system_Homo sapiens_hsa041221.30754197
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.22413561
37Basal transcription factors_Homo sapiens_hsa030221.21765881
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20391377
39Fatty acid degradation_Homo sapiens_hsa000711.17892314
40mRNA surveillance pathway_Homo sapiens_hsa030151.17740978
41Pyruvate metabolism_Homo sapiens_hsa006201.15314386
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14093250
43Steroid biosynthesis_Homo sapiens_hsa001001.10873961
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07951452
45Purine metabolism_Homo sapiens_hsa002301.06593776
46Caffeine metabolism_Homo sapiens_hsa002321.06556393
47Systemic lupus erythematosus_Homo sapiens_hsa053221.03477130
48Arginine biosynthesis_Homo sapiens_hsa002200.95109016
49Tryptophan metabolism_Homo sapiens_hsa003800.95029398
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94087597
51Pentose phosphate pathway_Homo sapiens_hsa000300.93803016
52Vitamin B6 metabolism_Homo sapiens_hsa007500.90988412
53p53 signaling pathway_Homo sapiens_hsa041150.89196390
54Nitrogen metabolism_Homo sapiens_hsa009100.88733027
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87150941
56Peroxisome_Homo sapiens_hsa041460.85198194
57Alzheimers disease_Homo sapiens_hsa050100.84506745
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83845871
59Glutathione metabolism_Homo sapiens_hsa004800.81286273
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79349034
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74838838
62Epstein-Barr virus infection_Homo sapiens_hsa051690.74008251
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73470108
64Chemical carcinogenesis_Homo sapiens_hsa052040.72180008
65beta-Alanine metabolism_Homo sapiens_hsa004100.69554406
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69367911
67Fatty acid elongation_Homo sapiens_hsa000620.68647887
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65833635
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65636222
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61245086
71Antigen processing and presentation_Homo sapiens_hsa046120.60537921
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56430783
73Complement and coagulation cascades_Homo sapiens_hsa046100.55523541
74Parkinsons disease_Homo sapiens_hsa050120.55335433
75Huntingtons disease_Homo sapiens_hsa050160.55317450
76Protein export_Homo sapiens_hsa030600.54744579
77Phenylalanine metabolism_Homo sapiens_hsa003600.54222135
78Metabolic pathways_Homo sapiens_hsa011000.53600345
79Arginine and proline metabolism_Homo sapiens_hsa003300.52840094
80Fatty acid metabolism_Homo sapiens_hsa012120.52759631
81Herpes simplex infection_Homo sapiens_hsa051680.50744811
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50158565
83Thyroid cancer_Homo sapiens_hsa052160.48496193
84Tyrosine metabolism_Homo sapiens_hsa003500.48341121
85TGF-beta signaling pathway_Homo sapiens_hsa043500.48063205
86Retinol metabolism_Homo sapiens_hsa008300.46663476
87Fructose and mannose metabolism_Homo sapiens_hsa000510.45934290
88N-Glycan biosynthesis_Homo sapiens_hsa005100.45918810
89Butanoate metabolism_Homo sapiens_hsa006500.45530899
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.45525672
91Lysine degradation_Homo sapiens_hsa003100.44878036
92Oocyte meiosis_Homo sapiens_hsa041140.44685569
93Galactose metabolism_Homo sapiens_hsa000520.44447498
94Starch and sucrose metabolism_Homo sapiens_hsa005000.41853870
95Fat digestion and absorption_Homo sapiens_hsa049750.41680139
96Viral carcinogenesis_Homo sapiens_hsa052030.41608668
97PPAR signaling pathway_Homo sapiens_hsa033200.38013558
98Legionellosis_Homo sapiens_hsa051340.35718017
99Vitamin digestion and absorption_Homo sapiens_hsa049770.35712104
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.35658017
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33566238
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33102025
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31539339
104MicroRNAs in cancer_Homo sapiens_hsa052060.28340979
105Wnt signaling pathway_Homo sapiens_hsa043100.28197581
106Alcoholism_Homo sapiens_hsa050340.28148716
107HTLV-I infection_Homo sapiens_hsa051660.27907908
108Colorectal cancer_Homo sapiens_hsa052100.26337929
109Sulfur metabolism_Homo sapiens_hsa009200.24944504
110Hippo signaling pathway_Homo sapiens_hsa043900.24605122
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24603725
112Histidine metabolism_Homo sapiens_hsa003400.23895436
113Adherens junction_Homo sapiens_hsa045200.20054137
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19783941
115Oxidative phosphorylation_Homo sapiens_hsa001900.18757588
116Basal cell carcinoma_Homo sapiens_hsa052170.14886025
117Small cell lung cancer_Homo sapiens_hsa052220.13880950
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.13131883
119Cardiac muscle contraction_Homo sapiens_hsa042600.09510194
120Prostate cancer_Homo sapiens_hsa052150.09449616
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.07035445
122Hedgehog signaling pathway_Homo sapiens_hsa043400.03287953
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.02950479
124Tight junction_Homo sapiens_hsa045300.02246912

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