ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of pigment cell differentiation (GO:0050932)	8.12074849
2	positive regulation of developmental pigmentation (GO:0048087)	7.84487353
3	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	7.56812011
4	regulation of meiosis I (GO:0060631)	7.55979970
5	DNA methylation involved in gamete generation (GO:0043046)	7.46310046
6	protein-chromophore linkage (GO:0018298)	7.34286089
7	lipopolysaccharide biosynthetic process (GO:0009103)	6.82517985
8	lipopolysaccharide metabolic process (GO:0008653)	6.14042182
9	sulfate transmembrane transport (GO:1902358)	6.02055282
10	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	5.59848276
11	regulation of protein glycosylation (GO:0060049)	5.56184731
12	piRNA metabolic process (GO:0034587)	5.39907340
13	paraxial mesoderm development (GO:0048339)	5.20402788
14	sulfate transport (GO:0008272)	5.18967869
15	meiotic chromosome segregation (GO:0045132)	5.11627852
16	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	5.01798871
17	negative regulation of glycoprotein biosynthetic process (GO:0010561)	4.96391934
18	negative regulation of cell cycle G2/M phase transition (GO:1902750)	4.92788030
19	heme transport (GO:0015886)	4.89466237
20	germinal center formation (GO:0002467)	4.75409219
21	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.58653500
22	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.53510090
23	positive regulation of dendritic spine morphogenesis (GO:0061003)	4.40641201
24	vitamin transmembrane transport (GO:0035461)	4.37152477
25	sympathetic nervous system development (GO:0048485)	4.34430981
26	positive regulation of meiosis (GO:0045836)	4.24104572
27	rhodopsin mediated signaling pathway (GO:0016056)	4.17284397
28	tyrosine metabolic process (GO:0006570)	4.16348887
29	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.09407785
30	L-phenylalanine catabolic process (GO:0006559)	4.09407785
31	response to nitrosative stress (GO:0051409)	4.02453264
32	ribonucleoprotein complex disassembly (GO:0032988)	3.99346585
33	regulation of developmental pigmentation (GO:0048070)	3.95383883
34	positive regulation of meiotic cell cycle (GO:0051446)	3.92665873
35	flavonoid metabolic process (GO:0009812)	3.90072597
36	notochord development (GO:0030903)	3.88676996
37	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.71795253
38	DNA deamination (GO:0045006)	3.67828292
39	cellular response to reactive nitrogen species (GO:1902170)	3.65509987
40	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.64981876
41	SMAD protein complex assembly (GO:0007183)	3.64855981
42	serotonin receptor signaling pathway (GO:0007210)	3.56894422
43	reciprocal meiotic recombination (GO:0007131)	3.55660176
44	reciprocal DNA recombination (GO:0035825)	3.55660176
45	iron coordination entity transport (GO:1901678)	3.55485600
46	negative regulation of glycoprotein metabolic process (GO:1903019)	3.54454099
47	tachykinin receptor signaling pathway (GO:0007217)	3.50460042
48	centriole replication (GO:0007099)	3.47323085
49	regulation of odontogenesis (GO:0042481)	3.37735571
50	negative regulation of stem cell proliferation (GO:2000647)	3.31191207
51	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.30426970
52	L-phenylalanine metabolic process (GO:0006558)	3.30426970
53	cellular response to gamma radiation (GO:0071480)	3.30111090
54	heart valve formation (GO:0003188)	3.28270607
55	regulation of transforming growth factor beta2 production (GO:0032909)	3.26526992
56	glutamate receptor signaling pathway (GO:0007215)	3.25941128
57	pantothenate metabolic process (GO:0015939)	3.23446440
58	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	3.23099410
59	postsynaptic membrane organization (GO:0001941)	3.18406627
60	sulfur compound transport (GO:0072348)	3.11461388
61	organelle disassembly (GO:1903008)	3.09291991
62	glycerol metabolic process (GO:0006071)	3.08153870
63	regulation of keratinocyte proliferation (GO:0010837)	3.06992954
64	regulation of interleukin-5 production (GO:0032674)	3.06519897
65	lysine metabolic process (GO:0006553)	3.00099162
66	lysine catabolic process (GO:0006554)	3.00099162
67	nodal signaling pathway (GO:0038092)	2.99757120
68	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.99219430
69	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.98010834
70	negative regulation of cell-matrix adhesion (GO:0001953)	2.90350075
71	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.88655128
72	cerebral cortex radially oriented cell migration (GO:0021799)	2.85926449
73	activation of protein kinase A activity (GO:0034199)	2.85818184
74	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.83495405
75	L-fucose catabolic process (GO:0042355)	2.82083064
76	fucose catabolic process (GO:0019317)	2.82083064
77	L-fucose metabolic process (GO:0042354)	2.82083064
78	aromatic amino acid family catabolic process (GO:0009074)	2.80822863
79	synaptic transmission, glutamatergic (GO:0035249)	2.80733868
80	cell migration in hindbrain (GO:0021535)	2.78412870
81	response to mercury ion (GO:0046689)	2.78224171
82	negative regulation of mast cell activation (GO:0033004)	2.77192707
83	cellular response to nitric oxide (GO:0071732)	2.75547297
84	negative regulation of norepinephrine secretion (GO:0010700)	2.72173792
85	aspartate family amino acid catabolic process (GO:0009068)	2.71104858
86	regulation of uterine smooth muscle contraction (GO:0070472)	2.69225739
87	somite rostral/caudal axis specification (GO:0032525)	2.68154189
88	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.67780851
89	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	2.64233865
90	alditol metabolic process (GO:0019400)	2.62760507
91	positive regulation of amine transport (GO:0051954)	2.61704894
92	chemosensory behavior (GO:0007635)	2.61587569
93	adaptation of signaling pathway (GO:0023058)	2.61435146
94	cellular response to sterol (GO:0036315)	2.59789189
95	positive regulation of SMAD protein import into nucleus (GO:0060391)	2.59341087
96	negative regulation of neural precursor cell proliferation (GO:2000178)	2.58841432
97	response to epinephrine (GO:0071871)	2.56659337
98	sphingosine metabolic process (GO:0006670)	13.0002110
99	diol metabolic process (GO:0034311)	11.8510367
100	sphingoid metabolic process (GO:0046519)	11.2916814

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.88999588
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.35626480
3	AR_21572438_ChIP-Seq_LNCaP_Human	3.97513742
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.24498395
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	3.09597713
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.65920170
7	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.36482860
8	P300_19829295_ChIP-Seq_ESCs_Human	2.32842075
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.27104648
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26432630
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19269813
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.08354236
13	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.02966749
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.97769071
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94304310
16	FUS_26573619_Chip-Seq_HEK293_Human	1.91308048
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.87083728
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86338916
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.86338916
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.85626564
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.84743295
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81634163
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.74073837
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.71197813
25	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.71190507
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.65092886
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63267485
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59177608
29	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55082350
30	TCF4_23295773_ChIP-Seq_U87_Human	1.54101688
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51699317
32	* STAT3_23295773_ChIP-Seq_U87_Human	1.50937108
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49646434
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.48206805
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.48206805
36	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.46693367
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45705564
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.45458438
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43985697
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.43400505
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.43363058
42	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.43274387
43	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.43046913
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.41347387
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41347387
46	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.40845342
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40211787
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39918085
49	AR_25329375_ChIP-Seq_VCAP_Human	1.39467429
50	VDR_22108803_ChIP-Seq_LS180_Human	1.39371473
51	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.35163186
52	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.32695743
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30719360
54	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30563458
55	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.30341036
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.30205499
57	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.29178075
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28348060
59	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.26835349
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26803790
61	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.26599174
62	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24471443
63	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24357264
64	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.23326697
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23042443
66	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.22454841
67	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.20837237
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20521607
69	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19234053
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17873799
71	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.16477790
72	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.15924691
73	TP53_18474530_ChIP-ChIP_U2OS_Human	1.15908696
74	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.15106478
75	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15087107
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12960597
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11710355
78	EWS_26573619_Chip-Seq_HEK293_Human	1.11427746
79	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.11421003
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11400648
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11279738
82	AR_19668381_ChIP-Seq_PC3_Human	1.10806510
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.09842534
84	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.09639623
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09179575
86	EGR1_19032775_ChIP-ChIP_M12_Human	1.08002500
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.07968563
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07612354
89	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.07021048
90	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.06100950
91	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05281961
92	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.04798171
93	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04539571
94	CJUN_26792858_Chip-Seq_BT549_Human	1.03995422
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02378791
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02078029
97	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.01509812
98	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.00940538
99	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00604043
100	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99024259

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	8.09250991
2	MP0003136_yellow_coat_color	6.91347942
3	MP0005171_absent_coat_pigmentation	6.36027430
4	MP0002653_abnormal_ependyma_morphology	5.33575857
5	MP0000569_abnormal_digit_pigmentation	4.77693982
6	MP0003045_fibrosis	4.75255267
7	MP0003890_abnormal_embryonic-extraembry	3.62424404
8	MP0003646_muscle_fatigue	3.36738785
9	MP0003879_abnormal_hair_cell	3.13760016
10	MP0005670_abnormal_white_adipose	3.05592084
11	MP0004381_abnormal_hair_follicle	2.92212367
12	MP0002168_other_aberrant_phenotype	2.16600202
13	MP0002735_abnormal_chemical_nociception	2.12499669
14	MP0005075_abnormal_melanosome_morpholog	2.04080775
15	MP0002138_abnormal_hepatobiliary_system	1.99158586
16	MP0005085_abnormal_gallbladder_physiolo	1.85934380
17	MP0003137_abnormal_impulse_conducting	1.64158432
18	MP0005174_abnormal_tail_pigmentation	1.60964278
19	MP0003195_calcinosis	1.60797068
20	MP0001486_abnormal_startle_reflex	1.54904982
21	MP0002095_abnormal_skin_pigmentation	1.50724269
22	MP0001501_abnormal_sleep_pattern	1.49826832
23	MP0009046_muscle_twitch	1.47354403
24	MP0000749_muscle_degeneration	1.45489530
25	MP0001984_abnormal_olfaction	1.40988998
26	MP0002938_white_spotting	1.34089930
27	MP0003705_abnormal_hypodermis_morpholog	1.28487414
28	MP0005395_other_phenotype	1.25874931
29	MP0002075_abnormal_coat/hair_pigmentati	1.25853755
30	MP0004859_abnormal_synaptic_plasticity	1.23866230
31	MP0004233_abnormal_muscle_weight	1.20694878
32	MP0001529_abnormal_vocalization	1.19816443
33	MP0002160_abnormal_reproductive_system	1.17163446
34	MP0008872_abnormal_physiological_respon	1.16635514
35	MP0000015_abnormal_ear_pigmentation	1.12134958
36	MP0002272_abnormal_nervous_system	1.09172865
37	MP0002733_abnormal_thermal_nociception	1.04538947
38	MP0003635_abnormal_synaptic_transmissio	1.04159987
39	MP0004147_increased_porphyrin_level	1.03280227
40	MP0001970_abnormal_pain_threshold	1.02382078
41	MP0010352_gastrointestinal_tract_polyps	1.00985770
42	MP0003183_abnormal_peptide_metabolism	0.96779632
43	MP0009745_abnormal_behavioral_response	0.92626382
44	MP0001440_abnormal_grooming_behavior	0.92521732
45	MP0002572_abnormal_emotion/affect_behav	0.88226908
46	MP0004043_abnormal_pH_regulation	0.86510176
47	MP0005551_abnormal_eye_electrophysiolog	0.86194260
48	MP0002971_abnormal_brown_adipose	0.80206557
49	MP0004270_analgesia	0.80183773
50	MP0005365_abnormal_bile_salt	0.79816923
51	MP0001186_pigmentation_phenotype	0.78517004
52	MP0002064_seizures	0.78147440
53	MP0008569_lethality_at_weaning	0.77614160
54	MP0005386_behavior/neurological_phenoty	0.76264353
55	MP0004924_abnormal_behavior	0.76264353
56	MP0000778_abnormal_nervous_system	0.70530485
57	MP0002269_muscular_atrophy	0.68760089
58	MP0003632_abnormal_nervous_system	0.67744744
59	MP0001968_abnormal_touch/_nociception	0.67419868
60	MP0002067_abnormal_sensory_capabilities	0.66053833
61	MP0002063_abnormal_learning/memory/cond	0.65962885
62	MP0000534_abnormal_ureter_morphology	0.65905688
63	MP0002229_neurodegeneration	0.65464001
64	MP0003329_amyloid_beta_deposits	0.65060480
65	MP0008770_decreased_survivor_rate	0.63738184
66	MP0005330_cardiomyopathy	0.57074235
67	MP0005410_abnormal_fertilization	0.55998215
68	MP0003787_abnormal_imprinting	0.54730495
69	MP0000427_abnormal_hair_cycle	0.53807689
70	MP0002277_abnormal_respiratory_mucosa	0.53755377
71	MP0008877_abnormal_DNA_methylation	0.52979000
72	MP0002734_abnormal_mechanical_nocicepti	0.52272466
73	MP0005389_reproductive_system_phenotype	0.52061151
74	MP0002876_abnormal_thyroid_physiology	0.51986360
75	MP0001324_abnormal_eye_pigmentation	0.51678037
76	MP0003252_abnormal_bile_duct	0.49281444
77	MP0002102_abnormal_ear_morphology	0.47901872
78	MP0003631_nervous_system_phenotype	0.47818415
79	MP0002882_abnormal_neuron_morphology	0.47764884
80	MP0002557_abnormal_social/conspecific_i	0.46722776
81	MP0000371_diluted_coat_color	0.45429846
82	MP0006072_abnormal_retinal_apoptosis	0.44951512
83	MP0002254_reproductive_system_inflammat	0.44132396
84	MP0004142_abnormal_muscle_tone	0.43329307
85	MP0000026_abnormal_inner_ear	0.43282980
86	MP0003698_abnormal_male_reproductive	0.43148202
87	MP0002736_abnormal_nociception_after	0.42932147
88	MP0008789_abnormal_olfactory_epithelium	0.42861744
89	MP0009115_abnormal_fat_cell	0.39981262
90	MP0002752_abnormal_somatic_nervous	0.39892571
91	MP0004484_altered_response_of	0.39866187
92	MP0005620_abnormal_muscle_contractility	0.39466519
93	MP0003959_abnormal_lean_body	0.39426657
94	MP0002928_abnormal_bile_duct	0.39215591
95	MP0001963_abnormal_hearing_physiology	0.39128905
96	MP0002751_abnormal_autonomic_nervous	0.38306673
97	MP0003937_abnormal_limbs/digits/tail_de	0.36796735
98	MP0005394_taste/olfaction_phenotype	0.36418394
99	MP0005499_abnormal_olfactory_system	0.36418394
100	MP0005195_abnormal_posterior_eye	0.35869058

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	8.37409320
2	Amelogenesis imperfecta (HP:0000705)	7.46059939
3	Parakeratosis (HP:0001036)	6.15831997
4	Acanthocytosis (HP:0001927)	5.75795373
5	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	5.50296483
6	Pancreatic cysts (HP:0001737)	4.68012411
7	Dialeptic seizures (HP:0011146)	4.67127534
8	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.27856152
9	Focal seizures (HP:0007359)	3.84731767
10	Colon cancer (HP:0003003)	3.72291668
11	Hematochezia (HP:0002573)	3.57782652
12	Aplastic anemia (HP:0001915)	3.57131865
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.50331627
14	Proximal amyotrophy (HP:0007126)	3.47090946
15	Spontaneous hematomas (HP:0007420)	3.32916771
16	Abnormality of the renal medulla (HP:0100957)	3.25017908
17	Nephronophthisis (HP:0000090)	3.23577174
18	Rectal prolapse (HP:0002035)	3.23112728
19	Erythroderma (HP:0001019)	3.18650166
20	Difficulty walking (HP:0002355)	3.10367000
21	Congenital stationary night blindness (HP:0007642)	3.01440711
22	Abnormality of the renal cortex (HP:0011035)	3.00142332
23	Chromsome breakage (HP:0040012)	2.98521888
24	Pancreatic fibrosis (HP:0100732)	2.94537698
25	Esophageal varix (HP:0002040)	2.91473417
26	Congenital ichthyosiform erythroderma (HP:0007431)	2.91297658
27	Potter facies (HP:0002009)	2.88470261
28	Facial shape deformation (HP:0011334)	2.88470261
29	Overlapping toe (HP:0001845)	2.87954983
30	Febrile seizures (HP:0002373)	2.83463382
31	Poikilocytosis (HP:0004447)	2.68249609
32	Ulnar claw (HP:0001178)	2.66929649
33	Cystic liver disease (HP:0006706)	2.63543566
34	Global brain atrophy (HP:0002283)	2.60773185
35	Synostosis of carpal bones (HP:0005048)	2.58975841
36	Pendular nystagmus (HP:0012043)	2.58324802
37	Vertebral arch anomaly (HP:0008438)	2.50450423
38	Abnormality of the vocal cords (HP:0008777)	2.49645756
39	Duplicated collecting system (HP:0000081)	2.49042277
40	Prolonged partial thromboplastin time (HP:0003645)	2.48869242
41	Bile duct proliferation (HP:0001408)	2.46465674
42	Abnormal biliary tract physiology (HP:0012439)	2.46465674
43	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.44483061
44	Abnormality of the renal collecting system (HP:0004742)	2.42573063
45	Autoimmune hemolytic anemia (HP:0001890)	2.41554635
46	Scapular winging (HP:0003691)	2.41465980
47	Joint hemorrhage (HP:0005261)	2.40543914
48	True hermaphroditism (HP:0010459)	2.31700211
49	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.31273065
50	Inability to walk (HP:0002540)	2.29385345
51	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.26379321
52	Broad-based gait (HP:0002136)	2.22920555
53	Progressive inability to walk (HP:0002505)	2.20786857
54	Tubulointerstitial fibrosis (HP:0005576)	2.16491579
55	Cerebellar dysplasia (HP:0007033)	2.16434494
56	Molar tooth sign on MRI (HP:0002419)	2.15890824
57	Abnormality of midbrain morphology (HP:0002418)	2.15890824
58	Abnormality of the intrinsic pathway (HP:0010989)	2.15755608
59	Enlarged kidneys (HP:0000105)	2.11712137
60	Abnormality of macular pigmentation (HP:0008002)	2.11442839
61	Bilateral sensorineural hearing impairment (HP:0008619)	2.10948677
62	Conical tooth (HP:0000698)	2.10179482
63	Atonic seizures (HP:0010819)	2.10149988
64	Neoplasm of the small intestine (HP:0100833)	2.07688277
65	Conjunctival telangiectasia (HP:0000524)	2.03190143
66	Absence seizures (HP:0002121)	2.01551614
67	Volvulus (HP:0002580)	1.98761605
68	Tarsal synostosis (HP:0008368)	1.97377129
69	Broad ribs (HP:0000885)	1.97080638
70	Tubular atrophy (HP:0000092)	1.94313313
71	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.92568165
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89911863
73	Oligodontia (HP:0000677)	1.89350096
74	Reticulocytopenia (HP:0001896)	1.87326779
75	Asplenia (HP:0001746)	1.87161389
76	Synostosis involving bones of the lower limbs (HP:0009138)	1.86569756
77	Synostosis involving bones of the feet (HP:0009140)	1.86569756
78	Meningioma (HP:0002858)	1.84846119
79	Portal hypertension (HP:0001409)	1.84427288
80	Albinism (HP:0001022)	1.84067180
81	Hypokalemia (HP:0002900)	1.83565292
82	Drooling (HP:0002307)	1.83039753
83	Absent speech (HP:0001344)	1.81007566
84	Radial bowing (HP:0002986)	1.79944203
85	Vacuolated lymphocytes (HP:0001922)	1.79734073
86	Abnormal albumin level (HP:0012116)	1.78857583
87	Hypoalbuminemia (HP:0003073)	1.78857583
88	Retinitis pigmentosa (HP:0000510)	1.77870123
89	Ulnar bowing (HP:0003031)	1.77349419
90	Increased cerebral lipofuscin (HP:0011813)	1.74719495
91	Impaired smooth pursuit (HP:0007772)	1.74652343
92	Decreased circulating renin level (HP:0003351)	1.73951511
93	Severe visual impairment (HP:0001141)	1.73759415
94	Clubbing of toes (HP:0100760)	1.72593853
95	Type II lissencephaly (HP:0007260)	1.71956698
96	Congenital hepatic fibrosis (HP:0002612)	1.71776484
97	Excessive salivation (HP:0003781)	1.67344966
98	Clumsiness (HP:0002312)	1.67266651
99	Hyperalaninemia (HP:0003348)	1.66717553
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.66717553

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	9.73612030
2	STK38L	6.57104663
3	LATS2	5.72024116
4	PINK1	3.40412777
5	FRK	2.98740821
6	PRKD3	2.79261029
7	NLK	2.70821444
8	MAP3K4	2.61635818
9	STK38	2.48971757
10	ZAK	2.46725886
11	MAP3K6	2.35397927
12	MAP2K7	1.95207938
13	ACVR1B	1.86473074
14	MAP2K2	1.85476887
15	STK3	1.74945275
16	GRK1	1.52609467
17	MAP3K2	1.35796059
18	ADRBK2	1.34829086
19	MELK	1.20428011
20	BMPR1B	1.16854973
21	NEK2	1.12320529
22	PIK3CG	1.11775185
23	CASK	1.08510461
24	MAP2K4	1.05011114
25	KSR2	0.98923191
26	CSNK1A1L	0.93322584
27	CCNB1	0.90265503
28	EIF2AK3	0.90158627
29	WNK4	0.89335031
30	MARK1	0.79455753
31	DAPK2	0.78352985
32	ADRBK1	0.77320218
33	PRKAA2	0.68604052
34	GRK7	0.67183473
35	IRAK3	0.60404969
36	RET	0.54345134
37	PDPK1	0.54307745
38	MAP3K5	0.53857835
39	SIK2	0.49919676
40	NTRK3	0.44473947
41	CSNK1G1	0.44462991
42	STK39	0.44005459
43	TGFBR1	0.41975946
44	FER	0.35976448
45	DYRK1A	0.35706715
46	STK11	0.35122691
47	MAPK7	0.34054348
48	PRKD1	0.33901038
49	CDK3	0.33721713
50	GRK5	0.33512443
51	MAP2K6	0.33362440
52	PHKG1	0.31640038
53	PHKG2	0.31640038
54	TGFBR2	0.31433442
55	SCYL2	0.31340877
56	MAPK13	0.30239678
57	MAP2K1	0.30230881
58	WNK3	0.30220985
59	PBK	0.30123381
60	DYRK2	0.30061799
61	FGFR3	0.29324667
62	MAP3K1	0.27974683
63	OXSR1	0.26393197
64	TEC	0.26237925
65	TAOK1	0.26188655
66	CAMK2B	0.25214771
67	PRKCG	0.23655867
68	CDK5	0.22322605
69	PRKCE	0.21871067
70	PIM1	0.20401873
71	PRKG2	0.17691183
72	TAF1	0.16337698
73	TAOK3	0.15931322
74	CSNK1A1	0.15142204
75	PRKACA	0.13696938
76	CAMK2A	0.13695328
77	NUAK1	0.13242320
78	MAPK3	0.13042110
79	MOS	0.12994771
80	CSNK1D	0.12960839
81	PRKACB	0.12775272
82	MAPK8	0.11657203
83	GSK3B	0.11021708
84	PIK3CA	0.10858729
85	ABL1	0.10355188
86	PLK1	0.10311855
87	TNK2	0.09770977
88	TAOK2	0.09053426
89	TRIM28	0.09011580
90	MINK1	0.08722133
91	PLK4	0.07816869
92	CDK19	0.07731290
93	MAP4K2	0.06109846
94	TXK	0.04225890
95	SGK1	0.03976831
96	AKT2	0.03492272
97	MAPK1	0.03239350
98	PRKCB	0.02221522
99	CSNK1G2	0.02097810
100	MAPK4	0.01904267

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	6.40382394
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.93102010
3	Phototransduction_Homo sapiens_hsa04744	4.65663705
4	Sphingolipid metabolism_Homo sapiens_hsa00600	3.65132643
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.44702188
6	Nicotine addiction_Homo sapiens_hsa05033	3.31088545
7	Taste transduction_Homo sapiens_hsa04742	3.11180513
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.90136312
9	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.28748848
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.23084300
11	Morphine addiction_Homo sapiens_hsa05032	2.12132830
12	GABAergic synapse_Homo sapiens_hsa04727	1.92344008
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.83089354
14	Glutamatergic synapse_Homo sapiens_hsa04724	1.72297047
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.58380803
16	Phenylalanine metabolism_Homo sapiens_hsa00360	1.24957411
17	Butanoate metabolism_Homo sapiens_hsa00650	1.24190633
18	Serotonergic synapse_Homo sapiens_hsa04726	1.21156971
19	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.20719852
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20537520
21	Calcium signaling pathway_Homo sapiens_hsa04020	1.17671824
22	Circadian entrainment_Homo sapiens_hsa04713	1.15078906
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11668584
24	Histidine metabolism_Homo sapiens_hsa00340	1.10988886
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.07108761
26	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.05642897
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02317501
28	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.99133253
29	Nitrogen metabolism_Homo sapiens_hsa00910	0.98969418
30	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97808576
31	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.97577275
32	Salivary secretion_Homo sapiens_hsa04970	0.96856434
33	Tryptophan metabolism_Homo sapiens_hsa00380	0.93939515
34	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.86439739
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.85206514
36	Olfactory transduction_Homo sapiens_hsa04740	0.83772684
37	Bile secretion_Homo sapiens_hsa04976	0.83731132
38	Glycerolipid metabolism_Homo sapiens_hsa00561	0.83355852
39	Long-term depression_Homo sapiens_hsa04730	0.79063227
40	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.78795651
41	Basal transcription factors_Homo sapiens_hsa03022	0.76201915
42	Linoleic acid metabolism_Homo sapiens_hsa00591	0.74330774
43	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.72878594
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70499622
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66475235
46	cAMP signaling pathway_Homo sapiens_hsa04024	0.65996428
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65859427
48	ABC transporters_Homo sapiens_hsa02010	0.65528209
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65491676
50	One carbon pool by folate_Homo sapiens_hsa00670	0.61478075
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60794485
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60673076
53	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60497407
54	Viral myocarditis_Homo sapiens_hsa05416	0.60483423
55	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.58503071
56	Gap junction_Homo sapiens_hsa04540	0.58411717
57	VEGF signaling pathway_Homo sapiens_hsa04370	0.53866513
58	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51907595
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.50495141
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48339120
61	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.48172594
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.47821672
63	Fatty acid degradation_Homo sapiens_hsa00071	0.46917269
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.44881592
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44308122
66	Gastric acid secretion_Homo sapiens_hsa04971	0.44145144
67	Platelet activation_Homo sapiens_hsa04611	0.42483076
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42315938
69	GnRH signaling pathway_Homo sapiens_hsa04912	0.40592760
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40330516
71	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.37714065
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37337331
73	Colorectal cancer_Homo sapiens_hsa05210	0.36002008
74	Cholinergic synapse_Homo sapiens_hsa04725	0.35787745
75	Insulin secretion_Homo sapiens_hsa04911	0.34248378
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33453632
77	Lysine degradation_Homo sapiens_hsa00310	0.33120519
78	Fanconi anemia pathway_Homo sapiens_hsa03460	0.32930506
79	Tuberculosis_Homo sapiens_hsa05152	0.32031650
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.31595019
81	Retinol metabolism_Homo sapiens_hsa00830	0.31129343
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30857327
83	Renin secretion_Homo sapiens_hsa04924	0.30561192
84	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.28713036
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28172314
86	ECM-receptor interaction_Homo sapiens_hsa04512	0.26563717
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.26334716
88	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.26072403
89	Complement and coagulation cascades_Homo sapiens_hsa04610	0.25513623
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.24874041
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.24364745
92	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.24098793
93	Long-term potentiation_Homo sapiens_hsa04720	0.23722133
94	Oocyte meiosis_Homo sapiens_hsa04114	0.23403227
95	Adherens junction_Homo sapiens_hsa04520	0.20410460
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.19793440
97	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.18570551
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.17157707
99	Estrogen signaling pathway_Homo sapiens_hsa04915	0.16080439
100	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.15879804

TFAMP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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