TFAP2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)9.39048196
2melanin metabolic process (GO:0006582)8.47100230
3secondary metabolite biosynthetic process (GO:0044550)7.68872104
4desmosome organization (GO:0002934)7.59940651
5hemidesmosome assembly (GO:0031581)6.02616320
6establishment of skin barrier (GO:0061436)5.31861451
7molting cycle (GO:0042303)5.29774342
8hair cycle (GO:0042633)5.29774342
9limb bud formation (GO:0060174)5.18257276
10lateral sprouting from an epithelium (GO:0060601)5.09842882
11regulation of water loss via skin (GO:0033561)4.80470769
12negative regulation of keratinocyte proliferation (GO:0010839)4.60824151
13keratinocyte proliferation (GO:0043616)4.33216621
14keratinization (GO:0031424)4.24013826
15polarized epithelial cell differentiation (GO:0030859)4.14114978
16* keratinocyte development (GO:0003334)4.07739675
17tyrosine metabolic process (GO:0006570)3.81122252
18face development (GO:0060324)3.77415108
19cranial nerve morphogenesis (GO:0021602)3.66692029
20head development (GO:0060322)3.65635675
21embryonic skeletal joint morphogenesis (GO:0060272)3.57899666
22regulation of keratinocyte proliferation (GO:0010837)3.55200920
23keratinocyte differentiation (GO:0030216)3.37827893
24epidermis development (GO:0008544)3.31736486
25gap junction assembly (GO:0016264)3.30453938
26multicellular organismal water homeostasis (GO:0050891)3.29977420
27cardiac right ventricle morphogenesis (GO:0003215)3.28441529
28* sympathetic nervous system development (GO:0048485)3.24766333
29melanosome organization (GO:0032438)3.22739463
30melanocyte differentiation (GO:0030318)3.20861887
31regulation of cell proliferation involved in kidney development (GO:1901722)3.19602708
32regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.18859225
33mesonephros development (GO:0001823)3.18844471
34mesenchymal cell differentiation involved in kidney development (GO:0072161)3.18838249
35mesenchymal cell differentiation involved in renal system development (GO:2001012)3.18838249
36phenol-containing compound biosynthetic process (GO:0046189)3.18467519
37pattern specification involved in kidney development (GO:0061004)3.16496335
38positive regulation of interleukin-8 secretion (GO:2000484)3.15670212
39hair follicle morphogenesis (GO:0031069)3.14304306
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.13341627
41establishment of apical/basal cell polarity (GO:0035089)3.12158675
42regulation of mammary gland epithelial cell proliferation (GO:0033599)3.08211949
43long-chain fatty acid biosynthetic process (GO:0042759)3.07162880
44pigment cell differentiation (GO:0050931)3.06595693
45cell-substrate junction assembly (GO:0007044)3.05442480
46mitotic G1 DNA damage checkpoint (GO:0031571)3.04820678
47semaphorin-plexin signaling pathway (GO:0071526)3.04418665
48regulation of apoptotic process involved in morphogenesis (GO:1902337)3.00909798
49pigment granule organization (GO:0048753)3.00600060
50negative regulation of axon extension involved in axon guidance (GO:0048843)2.98712476
51regulation of somitogenesis (GO:0014807)2.97894857
52intermediate filament organization (GO:0045109)2.95178303
53mesenchymal to epithelial transition (GO:0060231)2.92895399
54mesenchymal cell differentiation (GO:0048762)2.92484324
55bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90549740
56endosome to pigment granule transport (GO:0043485)2.89945227
57endosome to melanosome transport (GO:0035646)2.89945227
58endothelial cell morphogenesis (GO:0001886)2.89681649
59negative regulation of cell fate commitment (GO:0010454)2.89602182
60hair cycle process (GO:0022405)2.88905667
61molting cycle process (GO:0022404)2.88905667
62sphingoid metabolic process (GO:0046519)2.88595375
63mitotic G1/S transition checkpoint (GO:0044819)2.88208811
64notochord development (GO:0030903)2.83290747
65endocardial cushion development (GO:0003197)2.80527447
66adherens junction assembly (GO:0034333)2.77762029
67hair follicle development (GO:0001942)2.77322852
68glucosamine-containing compound catabolic process (GO:1901072)2.75982406
69hippo signaling (GO:0035329)2.75909238
70G1 DNA damage checkpoint (GO:0044783)2.75899185
71regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.75299504
72regulation of tight junction assembly (GO:2000810)2.74369265
73adenine nucleotide transport (GO:0051503)2.74120862
74positive regulation of meiotic cell cycle (GO:0051446)2.73134080
75regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.72943896
76embryonic camera-type eye development (GO:0031076)2.71314856
77regulation of phospholipase A2 activity (GO:0032429)2.70612989
78purine ribonucleotide transport (GO:0015868)2.69219708
79epidermal cell differentiation (GO:0009913)2.67734023
80somatic stem cell division (GO:0048103)2.67484880
81negative regulation of cell aging (GO:0090344)2.67428987
82midgut development (GO:0007494)2.66363501
83kidney morphogenesis (GO:0060993)2.65839731
84regulation of timing of cell differentiation (GO:0048505)2.64690957
85negative regulation of axon guidance (GO:1902668)2.63183683
86positive regulation of cardiac muscle cell differentiation (GO:2000727)2.62940225
87positive regulation of keratinocyte differentiation (GO:0045618)2.61544602
88regulation of interleukin-8 secretion (GO:2000482)2.60066979
89Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59359925
90cell surface receptor signaling pathway involved in heart development (GO:0061311)2.59223007
91negative regulation of stem cell proliferation (GO:2000647)2.58743274
92regulation of cardioblast differentiation (GO:0051890)2.58200980
93radial glial cell differentiation (GO:0060019)2.57489677
94purine nucleotide transport (GO:0015865)2.57461077
95GDP-mannose metabolic process (GO:0019673)2.56478852
96water homeostasis (GO:0030104)2.56193972
97intestinal epithelial cell development (GO:0060576)2.55445132
98establishment or maintenance of monopolar cell polarity (GO:0061339)2.54995092
99establishment of monopolar cell polarity (GO:0061162)2.54995092
100negative regulation of catenin import into nucleus (GO:0035414)2.53229099
101interferon-gamma secretion (GO:0072643)2.51880983
102cerebral cortex radially oriented cell migration (GO:0021799)2.50402095
103mesenchymal-epithelial cell signaling (GO:0060638)2.50326907
104heart valve morphogenesis (GO:0003179)2.49651141
105cranial nerve structural organization (GO:0021604)2.48980773
106facial nerve structural organization (GO:0021612)2.48843123
107polyol transport (GO:0015791)2.48037257
108histone H3-K4 trimethylation (GO:0080182)2.47911492
109negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.47228881
110regulation of early endosome to late endosome transport (GO:2000641)2.46473967
111cell proliferation in forebrain (GO:0021846)2.46305499
112negative regulation of chondrocyte differentiation (GO:0032331)2.45030107
113dorsal/ventral axis specification (GO:0009950)2.44979706
114* forelimb morphogenesis (GO:0035136)2.44162133
115negative regulation of TOR signaling (GO:0032007)2.43742477
116ephrin receptor signaling pathway (GO:0048013)2.43297702
117uterus development (GO:0060065)2.42741767
118peptide cross-linking (GO:0018149)2.42110698
119Golgi transport vesicle coating (GO:0048200)2.41938143
120COPI coating of Golgi vesicle (GO:0048205)2.41938143
121regulation of establishment of planar polarity (GO:0090175)2.41919344
122regulation of axon extension involved in axon guidance (GO:0048841)2.41829548
123endothelial cell chemotaxis (GO:0035767)2.41816012
124establishment of tissue polarity (GO:0007164)2.41049948
125establishment of planar polarity (GO:0001736)2.41049948
126anterior/posterior axis specification, embryo (GO:0008595)2.40917365
127mitotic sister chromatid segregation (GO:0000070)2.40662834
128regulation of development, heterochronic (GO:0040034)2.40522182
129mammary gland epithelial cell differentiation (GO:0060644)2.40502843
130skin morphogenesis (GO:0043589)2.39958123
131otic vesicle formation (GO:0030916)2.39507381
132spinal cord association neuron differentiation (GO:0021527)2.38616906
133cell-substrate adherens junction assembly (GO:0007045)2.38258148
134focal adhesion assembly (GO:0048041)2.38258148
135atrioventricular valve morphogenesis (GO:0003181)2.38112164
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37486592
137maternal placenta development (GO:0001893)2.36829219
138ectoderm development (GO:0007398)2.36349739
139regulation of keratinocyte differentiation (GO:0045616)2.36342340
140pericardium development (GO:0060039)2.36159696
141proximal/distal pattern formation (GO:0009954)2.36156164
142* embryonic skeletal system morphogenesis (GO:0048704)2.35606518
143lens morphogenesis in camera-type eye (GO:0002089)2.35391496
144negative regulation of cell fate specification (GO:0009996)2.35294201
145mammary gland development (GO:0030879)2.34881532
146* retina layer formation (GO:0010842)2.34337602
147mammary gland epithelial cell proliferation (GO:0033598)2.34136117
148regulation of NFAT protein import into nucleus (GO:0051532)2.33985657
149regulation of mesenchymal cell apoptotic process (GO:2001053)2.33361931
150establishment of epithelial cell polarity (GO:0090162)2.32842705
151regulation of chromatin binding (GO:0035561)2.31686013
152regulation of hippo signaling (GO:0035330)2.31450855
153regulation of protein sumoylation (GO:0033233)2.30846268
154presynaptic membrane assembly (GO:0097105)2.30211961
155pigment biosynthetic process (GO:0046148)2.29883636
156epithelial cell-cell adhesion (GO:0090136)2.29789372
157branching involved in mammary gland duct morphogenesis (GO:0060444)2.29188637
158negative regulation of Ras GTPase activity (GO:0034261)2.29058265
159cochlea morphogenesis (GO:0090103)2.28868630
160presynaptic membrane organization (GO:0097090)2.28842927
161odontogenesis of dentin-containing tooth (GO:0042475)2.28823326
162* neural crest cell development (GO:0014032)2.28631441
163mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.28401889
164* embryonic forelimb morphogenesis (GO:0035115)2.28015328
165pharyngeal system development (GO:0060037)2.26033090
166asymmetric protein localization (GO:0008105)2.25917808
167regulation of axon guidance (GO:1902667)2.25532438
168regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.25172201
169branching involved in salivary gland morphogenesis (GO:0060445)2.24914019
170male sex determination (GO:0030238)2.24822868
171regulation of mesenchymal cell proliferation (GO:0010464)2.24227984
172epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.23854288
173dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.23852528
174DNA integration (GO:0015074)2.23667570
175regulation of hair cycle (GO:0042634)2.23656349
176regulation of chemokine secretion (GO:0090196)2.23574167
177regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.23252500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.15062186
2ZNF263_19887448_ChIP-Seq_K562_Human3.21998284
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.02904402
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92923304
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.88484999
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.77861296
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69255995
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.65875138
9* RACK7_27058665_Chip-Seq_MCF-7_Human2.63177401
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.61146092
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.48810396
12GBX2_23144817_ChIP-Seq_PC3_Human2.47566097
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46642457
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.29366858
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25293721
16EZH2_22144423_ChIP-Seq_EOC_Human2.21799802
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16843809
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15381009
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.15244203
20VDR_22108803_ChIP-Seq_LS180_Human2.14976103
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.12755352
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11990609
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11990609
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11302029
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10860311
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06987812
27AR_21572438_ChIP-Seq_LNCaP_Human2.06324917
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04603693
29E2F7_22180533_ChIP-Seq_HELA_Human2.04145048
30HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01756397
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.99832674
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.99456045
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98582586
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.95106943
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92351290
36RNF2_27304074_Chip-Seq_NSC_Mouse1.90449399
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89459584
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87880442
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86694226
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82878050
41* UBF1/2_26484160_Chip-Seq_HMECs_Human1.80029297
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79853479
43* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79109810
44* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79109810
45XRN2_22483619_ChIP-Seq_HELA_Human1.79056427
46VDR_21846776_ChIP-Seq_THP-1_Human1.78558537
47LXR_22292898_ChIP-Seq_THP-1_Human1.78308282
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77923927
49ATF3_27146783_Chip-Seq_COLON_Human1.75294937
50* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74173803
51* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74157179
52* RUNX1_27514584_Chip-Seq_MCF-7_Human1.73432128
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.72759727
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.72282758
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.70344596
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64361214
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.62571688
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61986056
59* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.60202926
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60149933
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59650570
62CLOCK_20551151_ChIP-Seq_293T_Human1.59139365
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57837003
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56383696
65AR_21909140_ChIP-Seq_LNCAP_Human1.54680725
66* TP63_19390658_ChIP-ChIP_HaCaT_Human1.54551705
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53865389
68* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52650982
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51330990
70* AHR_22903824_ChIP-Seq_MCF-7_Human1.49768456
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49029682
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47191875
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46273950
74* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45724947
75TP53_18474530_ChIP-ChIP_U2OS_Human1.44745759
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.44485063
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43758218
78* ARNT_22903824_ChIP-Seq_MCF-7_Human1.39425878
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.39323112
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39098556
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39068928
82CREB1_26743006_Chip-Seq_LNCaP_Human1.38820374
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38800720
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38062188
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37279544
86TP53_16413492_ChIP-PET_HCT116_Human1.36378822
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36361185
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36138957
89* KDM2B_26808549_Chip-Seq_K562_Human1.35995905
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34828197
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33814497
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.33463563
93CHD1_26751641_Chip-Seq_LNCaP_Human1.32910984
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.32589676
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32204650
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31490828
97DCP1A_22483619_ChIP-Seq_HELA_Human1.31027385
98* TAF15_26573619_Chip-Seq_HEK293_Human1.29078636
99FUS_26573619_Chip-Seq_HEK293_Human1.28974897
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28914521
101SMC4_20622854_ChIP-Seq_HELA_Human1.28427092
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28193213
103GATA6_25053715_ChIP-Seq_YYC3_Human1.27630879
104* P300_19829295_ChIP-Seq_ESCs_Human1.26472958
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25298689
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25249090
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25073460
108TP53_22127205_ChIP-Seq_IMR90_Human1.25025036
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25012501
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22639998
111KDM2B_26808549_Chip-Seq_DND41_Human1.22603865
112ESR1_21235772_ChIP-Seq_MCF-7_Human1.22384424
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22233094
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20837116
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19960506
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19009692
117MYC_22102868_ChIP-Seq_BL_Human1.18925402
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18683417
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.18418849
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17753009
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17668308
122ERG_21242973_ChIP-ChIP_JURKAT_Human1.17642515
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.17454794
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.16837347
125P68_20966046_ChIP-Seq_HELA_Human1.16751503
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16476580
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15780251
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14375474
129POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13763675
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13620093
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13386575
132CDX2_20551321_ChIP-Seq_CACO-2_Human1.13050065
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12651432
134NFE2_27457419_Chip-Seq_LIVER_Mouse1.12617300
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.12126370
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10007053
137ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08343776
138KDM5A_27292631_Chip-Seq_BREAST_Human1.07112974
139KLF5_25053715_ChIP-Seq_YYC3_Human1.06954734
140TCF4_18268006_ChIP-ChIP_LS174T_Human1.06831927
141TRIM28_21343339_ChIP-Seq_HEK293_Human1.06324069
142TET1_21451524_ChIP-Seq_MESCs_Mouse1.06318581
143BCAT_22108803_ChIP-Seq_LS180_Human1.06178372
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06015090
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06015090
146EWS_26573619_Chip-Seq_HEK293_Human1.05540373
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05406147
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05055739
149SMAD4_21799915_ChIP-Seq_A2780_Human1.04685916
150SMAD3_21741376_ChIP-Seq_HESCs_Human1.04631536
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03143170
152ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02697223
153ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02391908
154* CJUN_26792858_Chip-Seq_BT549_Human1.02294553
155P53_22387025_ChIP-Seq_ESCs_Mouse1.02080409
156MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00666859
157CMYC_18555785_Chip-Seq_ESCs_Mouse1.00317907
158TCF7_22412390_ChIP-Seq_EML_Mouse1.00135885
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.99749837
160* MITF_21258399_ChIP-Seq_MELANOMA_Human0.99448308
161* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99350393
162SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99091372
163TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98740560
164KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98418627
165SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98017965
166IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97955738
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97615587
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97550429
169EZH2_27294783_Chip-Seq_NPCs_Mouse0.96923668
170MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96700474
171MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96305756
172UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95478154
173TTF2_22483619_ChIP-Seq_HELA_Human0.94897568
174P300_18555785_Chip-Seq_ESCs_Mouse0.94776867
175TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94573574
176TFEB_21752829_ChIP-Seq_HELA_Human0.94094692
177PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92929820
178EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92902422
179TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92408132
180SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92189918
181CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92147855
182OCT4_18555785_Chip-Seq_ESCs_Mouse0.91858568
183NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91472776
184AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90929097
185CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90898987
186EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90873931
187SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90516336
188ISL1_27105846_Chip-Seq_CPCs_Mouse0.89967705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle4.01791995
2MP0000383_abnormal_hair_follicle3.72958454
3MP0002796_impaired_skin_barrier3.66358680
4MP0002877_abnormal_melanocyte_morpholog3.59046814
5MP0000579_abnormal_nail_morphology3.55475360
6MP0000566_synostosis3.44172313
7MP0003941_abnormal_skin_development3.34580277
8MP0005408_hypopigmentation3.10621344
9MP0002098_abnormal_vibrissa_morphology3.09950264
10MP0003136_yellow_coat_color2.84235414
11MP0000647_abnormal_sebaceous_gland2.78137449
12MP0010678_abnormal_skin_adnexa2.72871682
13MP0002249_abnormal_larynx_morphology2.58961381
14MP0002254_reproductive_system_inflammat2.58244765
15MP0000762_abnormal_tongue_morphology2.54731692
16MP0001346_abnormal_lacrimal_gland2.52680442
17MP0002102_abnormal_ear_morphology2.50870221
18MP0003705_abnormal_hypodermis_morpholog2.41969461
19MP0005501_abnormal_skin_physiology2.32252526
20MP0005409_darkened_coat_color2.31542323
21MP0002060_abnormal_skin_morphology2.28521652
22MP0001188_hyperpigmentation2.26818813
23MP0010030_abnormal_orbit_morphology2.11092931
24MP0001216_abnormal_epidermal_layer2.00758153
25MP0000371_diluted_coat_color2.00059400
26MP0005171_absent_coat_pigmentation1.99459195
27MP0000467_abnormal_esophagus_morphology1.98503696
28MP0009379_abnormal_foot_pigmentation1.98350019
29MP0003938_abnormal_ear_development1.88667944
30MP0000377_abnormal_hair_follicle1.87050279
31MP0008789_abnormal_olfactory_epithelium1.83596623
32MP0000427_abnormal_hair_cycle1.82515488
33MP0010771_integument_phenotype1.80932462
34MP0005275_abnormal_skin_tensile1.80003835
35MP0000049_abnormal_middle_ear1.75999358
36MP0006292_abnormal_olfactory_placode1.74566432
37MP0005076_abnormal_cell_differentiation1.74111659
38MP0005083_abnormal_biliary_tract1.73943238
39MP0003453_abnormal_keratinocyte_physiol1.73615638
40MP0009250_abnormal_appendicular_skeleto1.65954992
41MP0002075_abnormal_coat/hair_pigmentati1.64605066
42MP0003755_abnormal_palate_morphology1.61217511
43MP0000569_abnormal_digit_pigmentation1.58049249
44MP0005197_abnormal_uvea_morphology1.57909424
45MP0003385_abnormal_body_wall1.52747595
46MP0003315_abnormal_perineum_morphology1.52054635
47MP0001186_pigmentation_phenotype1.51507949
48MP0001324_abnormal_eye_pigmentation1.47840222
49MP0002277_abnormal_respiratory_mucosa1.47007721
50MP0005499_abnormal_olfactory_system1.46800348
51MP0005394_taste/olfaction_phenotype1.46800348
52MP0000003_abnormal_adipose_tissue1.46763223
53MP0001340_abnormal_eyelid_morphology1.42724162
54MP0003937_abnormal_limbs/digits/tail_de1.42197343
55MP0004233_abnormal_muscle_weight1.39766522
56MP0002233_abnormal_nose_morphology1.38756556
57MP0005623_abnormal_meninges_morphology1.36657843
58MP0002009_preneoplasia1.35610372
59MP0005248_abnormal_Harderian_gland1.32323553
60MP0009053_abnormal_anal_canal1.31016511
61MP0002177_abnormal_outer_ear1.27785051
62MP0000537_abnormal_urethra_morphology1.22915173
63MP0002938_white_spotting1.18119786
64MP0000516_abnormal_urinary_system1.16328750
65MP0005367_renal/urinary_system_phenotyp1.16328750
66MP0008438_abnormal_cutaneous_collagen1.16196376
67MP0002282_abnormal_trachea_morphology1.13198540
68MP0000432_abnormal_head_morphology1.12232465
69MP0003566_abnormal_cell_adhesion1.11969034
70MP0009384_cardiac_valve_regurgitation1.09607979
71MP0000462_abnormal_digestive_system1.09524754
72MP0003111_abnormal_nucleus_morphology1.09363634
73MP0003787_abnormal_imprinting1.08975391
74MP0003950_abnormal_plasma_membrane1.08900212
75MP0001348_abnormal_lacrimal_gland1.08820813
76MP0005503_abnormal_tendon_morphology1.07649429
77MP0008995_early_reproductive_senescence1.07461706
78MP0010234_abnormal_vibrissa_follicle1.06458291
79MP0002116_abnormal_craniofacial_bone1.06228549
80MP0002234_abnormal_pharynx_morphology1.05287096
81MP0003693_abnormal_embryo_hatching1.00246891
82MP0006072_abnormal_retinal_apoptosis0.99774879
83MP0005423_abnormal_somatic_nervous0.99510547
84MP0000026_abnormal_inner_ear0.99429920
85MP0000613_abnormal_salivary_gland0.96898953
86MP0002751_abnormal_autonomic_nervous0.96727191
87MP0000778_abnormal_nervous_system0.96258549
88MP0002095_abnormal_skin_pigmentation0.96069042
89MP0001849_ear_inflammation0.95350493
90MP0008932_abnormal_embryonic_tissue0.95297734
91MP0002697_abnormal_eye_size0.94796712
92MP0004264_abnormal_extraembryonic_tissu0.94611072
93MP0003880_abnormal_central_pattern0.93796215
94MP0001286_abnormal_eye_development0.93400432
95MP0004858_abnormal_nervous_system0.92275971
96MP0002089_abnormal_postnatal_growth/wei0.91387199
97MP0010094_abnormal_chromosome_stability0.91379426
98MP0000534_abnormal_ureter_morphology0.90687466
99MP0004742_abnormal_vestibular_system0.89523758
100MP0005257_abnormal_intraocular_pressure0.89348260
101MP0000367_abnormal_coat/_hair0.89308673
102MP0003935_abnormal_craniofacial_develop0.89238416
103MP0000627_abnormal_mammary_gland0.88262533
104MP0003077_abnormal_cell_cycle0.87587392
105MP0004957_abnormal_blastocyst_morpholog0.86882648
106MP0005508_abnormal_skeleton_morphology0.85614605
107MP0005174_abnormal_tail_pigmentation0.85492782
108MP0000013_abnormal_adipose_tissue0.84202301
109MP0000631_abnormal_neuroendocrine_gland0.83562227
110MP0000470_abnormal_stomach_morphology0.83357733
111MP0009931_abnormal_skin_appearance0.82990754
112MP0003045_fibrosis0.82743836
113MP0001243_abnormal_dermal_layer0.82622594
114MP0005187_abnormal_penis_morphology0.81918038
115MP0002109_abnormal_limb_morphology0.81751219
116MP0001851_eye_inflammation0.81621700
117MP0005075_abnormal_melanosome_morpholog0.79089427
118MP0002160_abnormal_reproductive_system0.78163910
119MP0001191_abnormal_skin_condition0.76473826
120MP0000733_abnormal_muscle_development0.76335245
121MP0002111_abnormal_tail_morphology0.73565046
122MP0002932_abnormal_joint_morphology0.73381484
123MP0005058_abnormal_lysosome_morphology0.73035535
124MP0005023_abnormal_wound_healing0.72891365
125MP0004782_abnormal_surfactant_physiolog0.72225802
126MP0003936_abnormal_reproductive_system0.70137273
127MP0004272_abnormal_basement_membrane0.68733293
128MP0002752_abnormal_somatic_nervous0.67828742
129MP0000538_abnormal_urinary_bladder0.67466442
130MP0000163_abnormal_cartilage_morphology0.66681988
131MP0003942_abnormal_urinary_system0.66392966
132MP0000015_abnormal_ear_pigmentation0.64658249
133MP0002184_abnormal_innervation0.63976098
134MP0002114_abnormal_axial_skeleton0.63835762
135MP0000372_irregular_coat_pigmentation0.63391866
136MP0006138_congestive_heart_failure0.61585089
137MP0000678_abnormal_parathyroid_gland0.61520180
138MP0001984_abnormal_olfaction0.61376327
139MP0005193_abnormal_anterior_eye0.60854169
140MP0000350_abnormal_cell_proliferation0.60150908
141MP0004185_abnormal_adipocyte_glucose0.58900402
142MP0001486_abnormal_startle_reflex0.58236483
143MP0002092_abnormal_eye_morphology0.57606450
144MP0004197_abnormal_fetal_growth/weight/0.55377548

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)4.91750642
2Fragile nails (HP:0001808)4.56221343
3Parakeratosis (HP:0001036)4.52627636
4Milia (HP:0001056)4.52173682
5Onycholysis (HP:0001806)4.10565323
6Blue irides (HP:0000635)4.02611548
7Concave nail (HP:0001598)3.90994877
8Sparse lateral eyebrow (HP:0005338)3.87158171
9Plantar hyperkeratosis (HP:0007556)3.86931220
10Ocular albinism (HP:0001107)3.82300257
11* Aplasia cutis congenita (HP:0001057)3.64838682
12* White forelock (HP:0002211)3.62241735
13Septo-optic dysplasia (HP:0100842)3.59237208
14Septate vagina (HP:0001153)3.55885596
15Hypopigmentation of the fundus (HP:0007894)3.45422495
16Woolly hair (HP:0002224)3.36273801
17Selective tooth agenesis (HP:0001592)3.27562497
18Ulnar bowing (HP:0003031)3.24229845
19* Patchy hypopigmentation of hair (HP:0011365)3.20409503
20Atrophic scars (HP:0001075)3.17917534
21Breast hypoplasia (HP:0003187)3.15653083
22Aplasia/Hypoplasia of the macula (HP:0008059)3.15020456
23Iris hypopigmentation (HP:0007730)3.11084029
24Pili torti (HP:0003777)2.99208094
25Aplasia of the musculature (HP:0100854)2.92891779
26Aplasia/Hypoplasia affecting the retina (HP:0008061)2.90126070
27Popliteal pterygium (HP:0009756)2.88550464
28Abnormality of secondary sexual hair (HP:0009888)2.86648291
29Abnormality of the axillary hair (HP:0100134)2.86648291
30Thick nail (HP:0001805)2.84553582
31Abnormality of the parietal bone (HP:0002696)2.83507383
32Conical tooth (HP:0000698)2.81016895
33Hypoplasia of the iris (HP:0007676)2.78595752
34Natal tooth (HP:0000695)2.78172888
35Nail dystrophy (HP:0008404)2.77946514
36Palmoplantar hyperkeratosis (HP:0000972)2.77533263
37Abnormality of incisor morphology (HP:0011063)2.76790422
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.75693072
39Hypoplasia of the fovea (HP:0007750)2.75693072
40Palmar hyperkeratosis (HP:0010765)2.75512569
41Aplasia involving bones of the upper limbs (HP:0009823)2.71967847
42Aplasia of the phalanges of the hand (HP:0009802)2.71967847
43Aplasia involving bones of the extremities (HP:0009825)2.71967847
44Amelogenesis imperfecta (HP:0000705)2.69733971
45Freckling (HP:0001480)2.66330082
46Partial duplication of thumb phalanx (HP:0009944)2.63677616
47Sparse scalp hair (HP:0002209)2.63544277
48Abnormal auditory evoked potentials (HP:0006958)2.62706421
49Premature rupture of membranes (HP:0001788)2.56898050
50Abnormality of nail color (HP:0100643)2.56080358
51Alacrima (HP:0000522)2.54698272
52Esophageal atresia (HP:0002032)2.52485809
53Partial duplication of the phalanx of hand (HP:0009999)2.49404445
54Optic nerve hypoplasia (HP:0000609)2.49345248
55Absent septum pellucidum (HP:0001331)2.46000638
56Abnormality of the distal phalanges of the toes (HP:0010182)2.45524821
57Congenital ichthyosiform erythroderma (HP:0007431)2.44451026
58Upper limb muscle weakness (HP:0003484)2.40681503
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39160323
60Right ventricular cardiomyopathy (HP:0011663)2.36226298
61Heterochromia iridis (HP:0001100)2.30923094
62Generalized hypopigmentation (HP:0007513)2.30798700
63Abnormality of the labia majora (HP:0012881)2.29843847
64Underdeveloped nasal alae (HP:0000430)2.28331964
65Abnormality of the salivary glands (HP:0010286)2.23823373
66Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.23048109
67Absent eyebrow (HP:0002223)2.21010517
68Alopecia of scalp (HP:0002293)2.18292294
69Down-sloping shoulders (HP:0200021)2.18231310
70Hyperacusis (HP:0010780)2.17031487
71Cutaneous finger syndactyly (HP:0010554)2.15323041
72Abnormality of the septum pellucidum (HP:0007375)2.15251436
73Squamous cell carcinoma (HP:0002860)2.15110059
74Hypoplastic labia majora (HP:0000059)2.15038785
75Hypohidrosis (HP:0000966)2.13971061
76Advanced eruption of teeth (HP:0006288)2.12827951
77Abnormality of the fovea (HP:0000493)2.12114438
78Chin dimple (HP:0010751)2.10720224
79Hypoplasia of dental enamel (HP:0006297)2.09592773
80Abnormality of the phalanges of the 5th finger (HP:0004213)2.08808061
81Ridged nail (HP:0001807)2.06747982
82Duplication of thumb phalanx (HP:0009942)2.06703048
83Coronal craniosynostosis (HP:0004440)2.06455352
84Cutaneous melanoma (HP:0012056)2.06355356
85Corneal erosion (HP:0200020)2.05499353
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04402390
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04157623
88Thin bony cortex (HP:0002753)2.03599917
89Symphalangism affecting the phalanges of the hand (HP:0009773)2.03192647
90Protrusio acetabuli (HP:0003179)2.02485191
91Abnormal blistering of the skin (HP:0008066)2.01176693
92Ectropion (HP:0000656)2.01068522
93Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01059672
94Generalized hypopigmentation of hair (HP:0011358)2.00728277
95Oligodontia (HP:0000677)2.00456163
96* Premature graying of hair (HP:0002216)1.99550669
97Trismus (HP:0000211)1.99510821
98Decreased lacrimation (HP:0000633)1.99366151
99Absent/shortened dynein arms (HP:0200106)1.99204064
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.99204064
101Gastrointestinal atresia (HP:0002589)1.99163880
102Congenital, generalized hypertrichosis (HP:0004540)1.97208163
103Cupped ear (HP:0000378)1.95935561
104Short 5th finger (HP:0009237)1.94013143
105Hypodontia (HP:0000668)1.91513611
106Broad face (HP:0000283)1.90964550
107Sparse eyelashes (HP:0000653)1.89695885
108Fragile skin (HP:0001030)1.88139347
109Shallow orbits (HP:0000586)1.87796203
110Poikiloderma (HP:0001029)1.85779852
111Corneal dystrophy (HP:0001131)1.85545462
112* Lip pit (HP:0100267)1.84846705
113Duplicated collecting system (HP:0000081)1.84767686
114Absent eyelashes (HP:0000561)1.84152339
115Testicular atrophy (HP:0000029)1.83509150
116Short middle phalanx of the 5th finger (HP:0004220)1.81710775
117Pterygium (HP:0001059)1.81678513
118Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81477175
119Abnormality of molar (HP:0011077)1.81283813
120Abnormality of molar morphology (HP:0011070)1.81283813
121Xerostomia (HP:0000217)1.81102136
122Distal lower limb muscle weakness (HP:0009053)1.80937553
123Cutaneous syndactyly (HP:0012725)1.80078709
124Renal dysplasia (HP:0000110)1.79446636
125Humeroradial synostosis (HP:0003041)1.79390741
126Synostosis involving the elbow (HP:0003938)1.79390741
127Abnormality of the incisor (HP:0000676)1.79354457
128Stomach cancer (HP:0012126)1.77731294
129* Overfolded helix (HP:0000396)1.77423225
130Abnormality of the middle phalanges of the toes (HP:0010183)1.75575454
131Abnormal hair laboratory examination (HP:0003328)1.74754108
132Abnormality of the dental root (HP:0006486)1.72541684
133Taurodontia (HP:0000679)1.72541684
134Abnormality of permanent molar morphology (HP:0011071)1.72541684
135* Nasolacrimal duct obstruction (HP:0000579)1.72428590
136Smooth philtrum (HP:0000319)1.71946341
137Increased number of teeth (HP:0011069)1.71049981
138Depressed nasal tip (HP:0000437)1.70593142
139* Abnormality of the lacrimal duct (HP:0011481)1.70103145
140Abnormality of the 2nd finger (HP:0004100)1.69411717
141* Abnormality of the nasolacrimal system (HP:0000614)1.69219842
142Akinesia (HP:0002304)1.69006723
143Abnormal ciliary motility (HP:0012262)1.68878229
144Cervical subluxation (HP:0003308)1.67088676
145Bowing of the arm (HP:0006488)1.66665377
146Bowed forearm bones (HP:0003956)1.66665377
147Erythroderma (HP:0001019)1.66051275
148Abnormal respiratory epithelium morphology (HP:0012253)1.65394155
149Abnormal respiratory motile cilium morphology (HP:0005938)1.65394155
150Hypoplasia of the ulna (HP:0003022)1.65295474
151Birth length less than 3rd percentile (HP:0003561)1.64382551
152Facial cleft (HP:0002006)1.62469399
153* Elbow flexion contracture (HP:0002987)1.59767870
154Albinism (HP:0001022)1.59157047
155Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.56670554
156Bladder diverticulum (HP:0000015)1.56459195
157Vascular calcification (HP:0004934)1.56379656
158Entropion (HP:0000621)1.54670820
159Abnormality of the dental pulp (HP:0006479)1.54237656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.28615203
2PDK24.25613696
3BLK3.86994227
4TRIB33.36637694
5MST1R2.88581476
6SIK12.88311650
7WEE12.79882624
8EPHB22.42761493
9TNIK2.39554641
10CDK32.35226402
11MKNK22.20843492
12EEF2K2.03799288
13GRK71.98287836
14LATS11.95823661
15MAPK151.94952901
16MKNK11.92057235
17TRPM71.86354983
18SIK31.66416754
19TLK11.66335782
20BMPR1B1.62478018
21MTOR1.62136055
22FER1.56880995
23INSRR1.55599471
24YES11.55236820
25SMG11.55009456
26EIF2AK21.48374219
27STK161.46571301
28NME21.43325921
29ZAK1.43079329
30ERBB31.37402377
31FGR1.34047081
32PRPF4B1.32951258
33DDR21.30027863
34PKN21.28970878
35GRK11.27925057
36EPHA21.27680365
37WNK41.25280239
38RIPK11.23768231
39BRSK11.21579966
40BMPR21.20981159
41PAK41.18524655
42MAP3K61.14908219
43BCR1.14488956
44AKT31.13197664
45NTRK11.11888331
46BRSK21.11644250
47PKN11.10794568
48MST41.10329509
49EPHA41.09774785
50TGFBR11.01547379
51MET1.01142001
52ICK1.00094590
53PRKCE0.99472598
54NEK60.99472448
55MAPK130.97533004
56BRD40.97244668
57NUAK10.94978562
58STK390.93927780
59MUSK0.93526932
60MAP3K30.93304890
61PDGFRA0.92873116
62PBK0.92095060
63EPHA30.91400169
64OXSR10.91315182
65MAPKAPK50.90263774
66DYRK1A0.87649326
67PIK3CG0.86574904
68NME10.86541794
69EIF2AK10.86097192
70TRIM280.85797151
71FGFR20.85555019
72IRAK10.85257761
73MARK20.84183855
74PRKD20.84020174
75TESK10.83765393
76SRPK10.79873986
77MELK0.79244040
78STK38L0.79237965
79TAOK20.79086561
80EPHB10.78030648
81DYRK20.76655168
82UHMK10.75330513
83BMX0.75065439
84STK380.74435657
85MAP3K20.73788730
86RPS6KA20.72802005
87PTK60.72168364
88NLK0.71044372
89ADRBK20.69568138
90NEK20.69263523
91AKT20.68580147
92CDK120.67610315
93MAPKAPK30.67199721
94TNK20.66910161
95MARK30.66349899
96PIM20.65200041
97CDK60.65052643
98MAPK110.64713029
99PIK3CA0.64563843
100DMPK0.63927523
101ERN10.63831236
102AURKA0.62883419
103MATK0.62292875
104CHEK20.61809849
105PAK20.61557119
106CAMK2A0.61323681
107ILK0.60721728
108NTRK20.59050211
109NTRK30.57648129
110ADRBK10.56185964
111CDC42BPA0.56057954
112STK30.55756577
113LATS20.55257308
114PDGFRB0.54791210
115PRKD30.54460911
116GSK3A0.54003668
117SIK20.53492077
118ABL20.53207840
119GRK50.52016263
120MAP2K10.51876689
121CSNK1A1L0.51703847
122MAP3K140.51303648
123HIPK20.50877166
124AURKB0.50700029
125CAMK1G0.50516157
126PRKCI0.50186188
127PRKAA20.49645515
128ERBB20.49595235
129STK240.49048570
130DYRK30.48102369
131BUB10.47790585
132MAPKAPK20.47574582
133CAMK2B0.47288267
134SGK10.47013135
135PTK20.45670012
136RPS6KA10.44008048
137CHUK0.43618926
138IRAK30.43426999
139RPS6KB20.42963854
140LMTK20.42910609
141TGFBR20.42902211
142CDK70.42894724
143ACVR1B0.42845346
144IKBKB0.41652764
145RPS6KL10.40743220
146RPS6KC10.40743220
147CHEK10.40418486
148CAMK1D0.40072204
149RAF10.39730443
150RPS6KA60.38876829
151LIMK10.37999602
152CSK0.37370519
153DYRK1B0.37283193
154PDPK10.37033779
155PRKG10.36713980
156PLK10.36374419
157WNK10.34799397
158ATR0.34625107
159ERBB40.34534242
160MAP2K20.33818818
161MAPK120.33789422
162FGFR10.33711921
163TXK0.33296254
164PNCK0.33213271
165MAPK70.32137812

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.05120282
2Basal cell carcinoma_Homo sapiens_hsa052172.91647750
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.62061179
4Phototransduction_Homo sapiens_hsa047442.50780318
5Hedgehog signaling pathway_Homo sapiens_hsa043402.36193383
6Thyroid cancer_Homo sapiens_hsa052162.11923915
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07931354
8Axon guidance_Homo sapiens_hsa043602.00708146
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82968079
10Nicotine addiction_Homo sapiens_hsa050331.81436142
11Wnt signaling pathway_Homo sapiens_hsa043101.76181762
12Cell cycle_Homo sapiens_hsa041101.76097982
13Sphingolipid metabolism_Homo sapiens_hsa006001.73833378
14Fructose and mannose metabolism_Homo sapiens_hsa000511.70809501
15Hippo signaling pathway_Homo sapiens_hsa043901.66741072
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58094784
17Arachidonic acid metabolism_Homo sapiens_hsa005901.57687516
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57150069
19Lysine degradation_Homo sapiens_hsa003101.56467915
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54323662
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.49313981
22Tyrosine metabolism_Homo sapiens_hsa003501.48538949
23Ribosome_Homo sapiens_hsa030101.47952738
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46531127
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45379368
26ECM-receptor interaction_Homo sapiens_hsa045121.44355532
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44312204
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43877377
29Taste transduction_Homo sapiens_hsa047421.43148353
30Serotonergic synapse_Homo sapiens_hsa047261.42459939
31Chronic myeloid leukemia_Homo sapiens_hsa052201.42353050
32Graft-versus-host disease_Homo sapiens_hsa053321.40744654
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40482397
34Melanogenesis_Homo sapiens_hsa049161.35123528
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33766320
36Adherens junction_Homo sapiens_hsa045201.33303599
37Linoleic acid metabolism_Homo sapiens_hsa005911.29362820
38Ether lipid metabolism_Homo sapiens_hsa005651.26262389
39Melanoma_Homo sapiens_hsa052181.20629841
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20098879
41Vitamin B6 metabolism_Homo sapiens_hsa007501.19069614
42Fatty acid biosynthesis_Homo sapiens_hsa000611.18461071
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16672468
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15661670
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.12626947
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11839703
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11773459
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10928208
49mTOR signaling pathway_Homo sapiens_hsa041501.10823137
50RNA transport_Homo sapiens_hsa030131.09331235
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08639860
52MicroRNAs in cancer_Homo sapiens_hsa052061.08175800
53Fanconi anemia pathway_Homo sapiens_hsa034601.07965936
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07509289
55Long-term depression_Homo sapiens_hsa047301.05695909
56Calcium signaling pathway_Homo sapiens_hsa040201.04688928
57Ras signaling pathway_Homo sapiens_hsa040141.01716111
58TGF-beta signaling pathway_Homo sapiens_hsa043501.00668124
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00066027
60Salivary secretion_Homo sapiens_hsa049700.99903568
61Glutamatergic synapse_Homo sapiens_hsa047240.98430649
62Notch signaling pathway_Homo sapiens_hsa043300.97645564
63Biosynthesis of amino acids_Homo sapiens_hsa012300.97103258
64Other glycan degradation_Homo sapiens_hsa005110.95794793
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93306818
66DNA replication_Homo sapiens_hsa030300.93261969
67N-Glycan biosynthesis_Homo sapiens_hsa005100.92152843
68Pancreatic cancer_Homo sapiens_hsa052120.91598819
69mRNA surveillance pathway_Homo sapiens_hsa030150.91347149
70AMPK signaling pathway_Homo sapiens_hsa041520.90075469
71Rap1 signaling pathway_Homo sapiens_hsa040150.89854746
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89706531
73Insulin signaling pathway_Homo sapiens_hsa049100.89275558
74Non-small cell lung cancer_Homo sapiens_hsa052230.88201470
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87533022
76Pathways in cancer_Homo sapiens_hsa052000.87282323
77Renin secretion_Homo sapiens_hsa049240.86461392
78Tight junction_Homo sapiens_hsa045300.86192310
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85243517
80Glioma_Homo sapiens_hsa052140.84678578
81ErbB signaling pathway_Homo sapiens_hsa040120.82431400
82VEGF signaling pathway_Homo sapiens_hsa043700.81902606
83Hematopoietic cell lineage_Homo sapiens_hsa046400.81214450
84One carbon pool by folate_Homo sapiens_hsa006700.81033411
85Autoimmune thyroid disease_Homo sapiens_hsa053200.80565524
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80318343
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80141150
88Proteoglycans in cancer_Homo sapiens_hsa052050.79220361
89Fatty acid elongation_Homo sapiens_hsa000620.79043103
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78348372
91Homologous recombination_Homo sapiens_hsa034400.77609102
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77358980
93Colorectal cancer_Homo sapiens_hsa052100.76232252
94Nucleotide excision repair_Homo sapiens_hsa034200.75006988
95Endocytosis_Homo sapiens_hsa041440.73955535
96MAPK signaling pathway_Homo sapiens_hsa040100.72469846
97Small cell lung cancer_Homo sapiens_hsa052220.72233426
98p53 signaling pathway_Homo sapiens_hsa041150.71975221
99Prostate cancer_Homo sapiens_hsa052150.71483366
100FoxO signaling pathway_Homo sapiens_hsa040680.71441037
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71317167
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70858358
103Dorso-ventral axis formation_Homo sapiens_hsa043200.70595919
104Lysosome_Homo sapiens_hsa041420.70355594
105Steroid biosynthesis_Homo sapiens_hsa001000.69748136
106Acute myeloid leukemia_Homo sapiens_hsa052210.69615669
107Mineral absorption_Homo sapiens_hsa049780.69023080
108Amoebiasis_Homo sapiens_hsa051460.68905733
109Choline metabolism in cancer_Homo sapiens_hsa052310.68097852
110Olfactory transduction_Homo sapiens_hsa047400.67811489
111GnRH signaling pathway_Homo sapiens_hsa049120.67289629
112Circadian rhythm_Homo sapiens_hsa047100.66776151
113Morphine addiction_Homo sapiens_hsa050320.66092253
114Renal cell carcinoma_Homo sapiens_hsa052110.65254966
115Oxytocin signaling pathway_Homo sapiens_hsa049210.64742482
116Dilated cardiomyopathy_Homo sapiens_hsa054140.64579970
117Focal adhesion_Homo sapiens_hsa045100.64122867
118Pentose phosphate pathway_Homo sapiens_hsa000300.63096810
119Circadian entrainment_Homo sapiens_hsa047130.62061313
120Ovarian steroidogenesis_Homo sapiens_hsa049130.61563401
121Protein digestion and absorption_Homo sapiens_hsa049740.60161298
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59583651
123Basal transcription factors_Homo sapiens_hsa030220.59225166
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58941279
125cAMP signaling pathway_Homo sapiens_hsa040240.58795114
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.57724575
127Pyrimidine metabolism_Homo sapiens_hsa002400.57670861
128Base excision repair_Homo sapiens_hsa034100.56700127
129Glucagon signaling pathway_Homo sapiens_hsa049220.55495526
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54926515
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.54205515
132Insulin resistance_Homo sapiens_hsa049310.53039291
133Rheumatoid arthritis_Homo sapiens_hsa053230.51705999
134RNA polymerase_Homo sapiens_hsa030200.51338376
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.51148501
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51137558
137Galactose metabolism_Homo sapiens_hsa000520.50738248
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.50644459
139Viral carcinogenesis_Homo sapiens_hsa052030.49869857
140Pancreatic secretion_Homo sapiens_hsa049720.47506028
141Spliceosome_Homo sapiens_hsa030400.47192374
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47050160
143Bladder cancer_Homo sapiens_hsa052190.46785625
144Hepatitis C_Homo sapiens_hsa051600.46439891
145Retinol metabolism_Homo sapiens_hsa008300.45989484
146Estrogen signaling pathway_Homo sapiens_hsa049150.45504630
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45381016
148Gastric acid secretion_Homo sapiens_hsa049710.44782299
149Endometrial cancer_Homo sapiens_hsa052130.44597314
150Vibrio cholerae infection_Homo sapiens_hsa051100.44493332
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.44172739
152Inositol phosphate metabolism_Homo sapiens_hsa005620.43649317
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43590468
154Asthma_Homo sapiens_hsa053100.42677925
155Gap junction_Homo sapiens_hsa045400.42038096
156GABAergic synapse_Homo sapiens_hsa047270.41423697
157Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39042098
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38355256
159Collecting duct acid secretion_Homo sapiens_hsa049660.37584430
160HTLV-I infection_Homo sapiens_hsa051660.37254414
161cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37160767
162African trypanosomiasis_Homo sapiens_hsa051430.37126821

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