TFAP2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of inhibitory postsynaptic membrane potential (GO:0060080)7.10204270
2pyrimidine nucleobase catabolic process (GO:0006208)6.84057048
3regulation of respiratory gaseous exchange by neurological system process (GO:0002087)6.82792409
4histone arginine methylation (GO:0034969)6.46593801
5desmosome organization (GO:0002934)5.91685202
6regulation of respiratory system process (GO:0044065)5.83364162
7nucleobase catabolic process (GO:0046113)5.52158791
8* sympathetic nervous system development (GO:0048485)5.47398175
9positive regulation of cell cycle checkpoint (GO:1901978)5.28526296
10establishment of mitochondrion localization (GO:0051654)5.08710411
11neuronal action potential propagation (GO:0019227)4.78585365
12regulation of mitotic spindle checkpoint (GO:1903504)4.73258394
13regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.73258394
14hemidesmosome assembly (GO:0031581)4.72534412
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.55178148
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.45936953
17mitochondrion transport along microtubule (GO:0047497)4.45936953
18planar cell polarity pathway involved in neural tube closure (GO:0090179)4.45096398
19regulation of respiratory gaseous exchange (GO:0043576)4.44978120
20positive regulation by host of viral transcription (GO:0043923)4.41533800
21neuron recognition (GO:0008038)4.38990725
22postsynaptic membrane organization (GO:0001941)4.36401266
23regulation of dendritic cell antigen processing and presentation (GO:0002604)4.35569298
24lateral sprouting from an epithelium (GO:0060601)4.26190858
25positive regulation of vesicle fusion (GO:0031340)4.19434013
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.18953756
27adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.15427808
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.07301431
29auditory behavior (GO:0031223)4.06100616
30cell-cell junction maintenance (GO:0045217)4.01474634
31negative regulation of axon extension involved in axon guidance (GO:0048843)3.92391861
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.85910444
33positive regulation of synapse assembly (GO:0051965)3.85501618
34neuron remodeling (GO:0016322)3.76188586
35negative regulation of keratinocyte proliferation (GO:0010839)3.75548094
36dendritic spine morphogenesis (GO:0060997)3.70882633
37presynaptic membrane organization (GO:0097090)3.66363495
38regulation of short-term neuronal synaptic plasticity (GO:0048172)3.66071277
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.64933606
40negative regulation of axon guidance (GO:1902668)3.63219439
41regulation of vesicle fusion (GO:0031338)3.62614477
42G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.59567439
43histone H3-K4 trimethylation (GO:0080182)3.57814161
44cell junction maintenance (GO:0034331)3.54033540
45membrane hyperpolarization (GO:0060081)3.53542266
46rhodopsin mediated signaling pathway (GO:0016056)3.50716918
47ganglion development (GO:0061548)3.48630350
48positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.48629952
49regulation of rhodopsin mediated signaling pathway (GO:0022400)3.47290926
50neuronal ion channel clustering (GO:0045161)3.47003833
51presynaptic membrane assembly (GO:0097105)3.44843751
52photoreceptor cell differentiation (GO:0046530)3.42136474
53eye photoreceptor cell differentiation (GO:0001754)3.42136474
54membrane depolarization during action potential (GO:0086010)3.38502089
55neurotransmitter-gated ion channel clustering (GO:0072578)3.37460764
56behavioral response to nicotine (GO:0035095)3.36076618
57cranial nerve morphogenesis (GO:0021602)3.34970618
58response to prostaglandin E (GO:0034695)3.34543861
59phenol-containing compound catabolic process (GO:0019336)3.34222883
60positive regulation of membrane potential (GO:0045838)3.33363647
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33090441
62ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.30917673
63synaptic vesicle exocytosis (GO:0016079)3.30623300
64head development (GO:0060322)3.30534227
65mesenchyme morphogenesis (GO:0072132)3.29119929
66neuron cell-cell adhesion (GO:0007158)3.29099176
67cell migration in hindbrain (GO:0021535)3.25470902
68retinal ganglion cell axon guidance (GO:0031290)3.24532142
69endocardial cushion morphogenesis (GO:0003203)3.23883801
70central nervous system projection neuron axonogenesis (GO:0021952)3.23825624
71cornea development in camera-type eye (GO:0061303)3.22452282
72protein localization to synapse (GO:0035418)3.22195966
73regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.19255245
74axon extension (GO:0048675)3.18372096
75dendrite morphogenesis (GO:0048813)3.17907838
76middle ear morphogenesis (GO:0042474)3.17046135
77keratinocyte proliferation (GO:0043616)3.16229064
78catechol-containing compound biosynthetic process (GO:0009713)3.15961810
79catecholamine biosynthetic process (GO:0042423)3.15961810
80regulation of secondary heart field cardioblast proliferation (GO:0003266)3.14936317
81regulation of cardioblast proliferation (GO:0003264)3.14936317
82synapse assembly (GO:0007416)3.14499701
83neural crest cell development (GO:0014032)3.13024377
84establishment of planar polarity (GO:0001736)3.12945777
85establishment of tissue polarity (GO:0007164)3.12945777
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12563902
87neuromuscular synaptic transmission (GO:0007274)3.12089835
88Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.11906129
89non-canonical Wnt signaling pathway (GO:0035567)3.09396665
90sensory perception of pain (GO:0019233)3.06587181
91negative regulation of cell fate specification (GO:0009996)3.05888793
92negative regulation of catenin import into nucleus (GO:0035414)3.05357953
93regulation of axon extension involved in axon guidance (GO:0048841)3.04240094
94positive regulation of antigen processing and presentation (GO:0002579)3.03442885
95eyelid development in camera-type eye (GO:0061029)3.03039941
96axonal fasciculation (GO:0007413)3.03004956
97negative regulation of translation, ncRNA-mediated (GO:0040033)3.02090064
98regulation of translation, ncRNA-mediated (GO:0045974)3.02090064
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.02090064
100cerebellar granule cell differentiation (GO:0021707)3.02039207
101regulation of establishment of planar polarity (GO:0090175)3.01784098
102limb bud formation (GO:0060174)3.01498619
103layer formation in cerebral cortex (GO:0021819)3.00701789
104embryonic cranial skeleton morphogenesis (GO:0048701)2.99931992
105membrane depolarization (GO:0051899)2.97855459
106mesenchymal cell development (GO:0014031)2.97367308
107anatomical structure arrangement (GO:0048532)2.96944156
108cochlea morphogenesis (GO:0090103)2.96806827
109photoreceptor cell development (GO:0042461)2.96403710
110regulation of axon guidance (GO:1902667)2.95734617
111suckling behavior (GO:0001967)2.95029752
112regulation of synapse assembly (GO:0051963)2.93776365
113positive regulation of interleukin-1 beta secretion (GO:0050718)2.92624375
114glutamate receptor signaling pathway (GO:0007215)2.91669122
115keratinocyte development (GO:0003334)2.91057279
116mechanosensory behavior (GO:0007638)2.90794855
117embryonic body morphogenesis (GO:0010172)2.89774430
118regulation of synaptic vesicle transport (GO:1902803)2.89573503
119mesenchymal cell proliferation (GO:0010463)2.89052642
120positive regulation of gastrulation (GO:2000543)2.88801467
121embryonic forelimb morphogenesis (GO:0035115)2.88214256
122regulation of synaptic vesicle exocytosis (GO:2000300)2.87480373
123epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.87230570
124establishment of skin barrier (GO:0061436)2.85885688
125neuron maturation (GO:0042551)2.85707737
126keratinocyte differentiation (GO:0030216)2.85353288
127startle response (GO:0001964)2.85310203
128synaptic transmission, glutamatergic (GO:0035249)2.84827843
129eye photoreceptor cell development (GO:0042462)2.84792756
130regulation of action potential (GO:0098900)2.84028642
131body morphogenesis (GO:0010171)2.84010673
132regulation of glutamate receptor signaling pathway (GO:1900449)2.83855928
133exploration behavior (GO:0035640)2.83380065
134negative chemotaxis (GO:0050919)2.83270019
135response to auditory stimulus (GO:0010996)2.82667523
136dopamine receptor signaling pathway (GO:0007212)2.82552300
137regulation of spindle checkpoint (GO:0090231)2.82203197
138embryonic retina morphogenesis in camera-type eye (GO:0060059)2.82136235
139calcium ion-dependent exocytosis (GO:0017156)2.81763988
140regulation of mesenchymal cell apoptotic process (GO:2001053)2.81745576
141regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.80768283
142regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80719789
143adult walking behavior (GO:0007628)2.78565971
144synaptic transmission, cholinergic (GO:0007271)2.77149158
145mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.76729650
146positive regulation of microtubule polymerization (GO:0031116)2.74671222
147lens fiber cell development (GO:0070307)2.74136778
148protein polyglutamylation (GO:0018095)2.73478902
149cell surface receptor signaling pathway involved in heart development (GO:0061311)2.72335960
150neurotransmitter secretion (GO:0007269)2.71770008
151regulation of postsynaptic membrane potential (GO:0060078)2.71476685
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.70910126
153facial nerve structural organization (GO:0021612)2.70179981
154synaptic vesicle maturation (GO:0016188)2.68888532
155positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68516223
156chondrocyte development (GO:0002063)2.68377425
157photoreceptor cell maintenance (GO:0045494)2.67831103
158cell differentiation in hindbrain (GO:0021533)2.67313802
159tongue development (GO:0043586)2.67060910
160regulation of heart morphogenesis (GO:2000826)2.67060754
161positive regulation of interleukin-1 secretion (GO:0050716)2.66838926
162neuromuscular process controlling posture (GO:0050884)2.66110024
163positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65655970
164retinal cone cell development (GO:0046549)2.65032705
165regulation of dopamine secretion (GO:0014059)2.64758608
166positive regulation of action potential (GO:0045760)2.63929364
167axon extension involved in axon guidance (GO:0048846)2.63869767
168neuron projection extension involved in neuron projection guidance (GO:1902284)2.63869767
169cerebellar Purkinje cell differentiation (GO:0021702)2.63556949
170negative regulation of cell fate commitment (GO:0010454)2.60359192
171mesenchymal cell differentiation involved in kidney development (GO:0072161)2.58432819
172mesenchymal cell differentiation involved in renal system development (GO:2001012)2.58432819
173regulation of T-helper 1 cell differentiation (GO:0045625)2.57630584
174proximal/distal pattern formation (GO:0009954)2.55777935
175stem cell development (GO:0048864)2.53250570
176positive regulation of odontogenesis (GO:0042482)2.53018316
177dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52960492
178positive regulation of granulocyte chemotaxis (GO:0071624)2.52880372
179cardiac epithelial to mesenchymal transition (GO:0060317)2.51788784
180pattern specification involved in kidney development (GO:0061004)2.51553049
181* forelimb morphogenesis (GO:0035136)2.51502672
182phototransduction (GO:0007602)2.50854500
183mesenchymal to epithelial transition (GO:0060231)2.50007039
184chondrocyte differentiation (GO:0002062)2.49911949
185cartilage morphogenesis (GO:0060536)2.49834075
186detection of visible light (GO:0009584)2.49429264
187response to prostaglandin (GO:0034694)2.48616287
188phototransduction, visible light (GO:0007603)2.47548293
189dorsal/ventral axis specification (GO:0009950)2.47366949
190face morphogenesis (GO:0060325)2.47102901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.28793052
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.27084764
3EZH2_22144423_ChIP-Seq_EOC_Human3.25605413
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.91434909
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.70804831
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69200551
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60961964
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60961964
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57955796
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57433849
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52882190
12REST_21632747_ChIP-Seq_MESCs_Mouse2.52334788
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43279967
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41157675
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37544833
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31080811
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.26825666
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26416940
19AR_21572438_ChIP-Seq_LNCaP_Human2.25754019
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21735225
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.21233172
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.14510162
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14049675
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.08590438
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04265447
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.02945577
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00270742
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99700902
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97768029
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.97249008
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79782646
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76359044
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.71920998
34* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70133326
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69662206
36RNF2_27304074_Chip-Seq_NSC_Mouse1.68012637
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67469428
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66914884
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.66857077
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.66757848
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.65772650
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63578339
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61976827
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.58098136
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58086809
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.55930788
47AHR_22903824_ChIP-Seq_MCF-7_Human1.51857842
48GBX2_23144817_ChIP-Seq_PC3_Human1.49563849
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.47018009
50IGF1R_20145208_ChIP-Seq_DFB_Human1.46895829
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.46238903
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.44172857
53TP53_18474530_ChIP-ChIP_U2OS_Human1.41957216
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.41656935
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41308764
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.38134009
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38031686
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36311317
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.34693368
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34483198
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33638456
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.33177396
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32306018
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32180160
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31584140
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31089467
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.30550180
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30011934
69* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29586748
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28650887
71* P300_19829295_ChIP-Seq_ESCs_Human1.27802325
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27203793
73BCAT_22108803_ChIP-Seq_LS180_Human1.26122190
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.24620502
75TAF15_26573619_Chip-Seq_HEK293_Human1.22848540
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20699372
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20547294
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20347443
79DROSHA_22980978_ChIP-Seq_HELA_Human1.19020046
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.17611889
81VDR_22108803_ChIP-Seq_LS180_Human1.16294846
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15386629
83* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14053388
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13636818
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12914834
86SMAD4_21799915_ChIP-Seq_A2780_Human1.12065276
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11052524
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10665067
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10665067
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10665067
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08307281
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07407608
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.06572236
94AR_25329375_ChIP-Seq_VCAP_Human1.06452366
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06442501
96CJUN_26792858_Chip-Seq_BT549_Human1.05864390
97ZNF274_21170338_ChIP-Seq_K562_Hela1.05660860
98STAT3_23295773_ChIP-Seq_U87_Human1.05009217
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.04085803
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02330172
101SMAD3_21741376_ChIP-Seq_ESCs_Human1.02308098
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01972812
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01972812
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01815946
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01374190
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01256262
107EWS_26573619_Chip-Seq_HEK293_Human1.00741400
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00331803
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.00330240
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99666536
111TP53_16413492_ChIP-PET_HCT116_Human0.99539902
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98196106
113FUS_26573619_Chip-Seq_HEK293_Human0.97910571
114STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97298331
115CTCF_27219007_Chip-Seq_Bcells_Human0.97267985
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96426222
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95524616
118TCF4_22108803_ChIP-Seq_LS180_Human0.95203431
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94821910
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.94762232
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93725761
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.93038196
123* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92954807
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91607432
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91135396
126SOX9_26525672_Chip-Seq_HEART_Mouse0.90658157
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90235369
128KDM2B_26808549_Chip-Seq_K562_Human0.89651433
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88997667
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88976689
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88765428
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87582225
133AR_19668381_ChIP-Seq_PC3_Human0.87323817
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87047955
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86909701
136RXR_22108803_ChIP-Seq_LS180_Human0.86212514
137ER_23166858_ChIP-Seq_MCF-7_Human0.86180032
138* SOX2_21211035_ChIP-Seq_LN229_Gbm0.85892668
139* RUNX2_22187159_ChIP-Seq_PCA_Human0.85055313
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83916622
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83201806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.31231187
2MP0003122_maternal_imprinting4.30163639
3MP0001346_abnormal_lacrimal_gland3.45543106
4MP0003121_genomic_imprinting3.25216913
5MP0002254_reproductive_system_inflammat3.06494639
6MP0002735_abnormal_chemical_nociception3.00490291
7MP0000579_abnormal_nail_morphology2.94669632
8MP0000566_synostosis2.87453899
9MP0003880_abnormal_central_pattern2.74084164
10MP0003011_delayed_dark_adaptation2.70445167
11MP0003635_abnormal_synaptic_transmissio2.67273557
12MP0003787_abnormal_imprinting2.51683002
13MP0003941_abnormal_skin_development2.50481797
14MP0010030_abnormal_orbit_morphology2.47731864
15MP0005503_abnormal_tendon_morphology2.45214694
16MP0002796_impaired_skin_barrier2.35188792
17MP0005275_abnormal_skin_tensile2.33457579
18MP0002098_abnormal_vibrissa_morphology2.31516586
19MP0000383_abnormal_hair_follicle2.28149850
20MP0001984_abnormal_olfaction2.27841081
21MP0009053_abnormal_anal_canal2.26139063
22MP0008789_abnormal_olfactory_epithelium2.16919420
23MP0001968_abnormal_touch/_nociception2.15254256
24MP0000049_abnormal_middle_ear2.10853281
25MP0002063_abnormal_learning/memory/cond2.09411613
26MP0000762_abnormal_tongue_morphology2.08219953
27MP0001529_abnormal_vocalization2.08103555
28MP0002249_abnormal_larynx_morphology2.04799671
29MP0004742_abnormal_vestibular_system2.02712804
30MP0003385_abnormal_body_wall1.94538881
31MP0002272_abnormal_nervous_system1.93502583
32MP0000955_abnormal_spinal_cord1.93287472
33MP0000537_abnormal_urethra_morphology1.93145006
34MP0005551_abnormal_eye_electrophysiolog1.92968209
35MP0004270_analgesia1.91055914
36MP0000647_abnormal_sebaceous_gland1.89934078
37MP0000538_abnormal_urinary_bladder1.89564394
38MP0009250_abnormal_appendicular_skeleto1.86967582
39MP0010678_abnormal_skin_adnexa1.86880093
40MP0003942_abnormal_urinary_system1.86527375
41MP0001970_abnormal_pain_threshold1.83604117
42MP0010234_abnormal_vibrissa_follicle1.82769802
43MP0005248_abnormal_Harderian_gland1.81895040
44MP0004885_abnormal_endolymph1.81347425
45MP0003755_abnormal_palate_morphology1.81207561
46MP0002638_abnormal_pupillary_reflex1.76917497
47MP0002909_abnormal_adrenal_gland1.75886073
48MP0009046_muscle_twitch1.75876002
49MP0005377_hearing/vestibular/ear_phenot1.75244514
50MP0003878_abnormal_ear_physiology1.75244514
51MP0003937_abnormal_limbs/digits/tail_de1.74604641
52MP0004381_abnormal_hair_follicle1.73627415
53MP0002572_abnormal_emotion/affect_behav1.71734068
54MP0005386_behavior/neurological_phenoty1.71634744
55MP0004924_abnormal_behavior1.71634744
56MP0009745_abnormal_behavioral_response1.69500628
57MP0002736_abnormal_nociception_after1.66381121
58MP0001905_abnormal_dopamine_level1.65818821
59MP0002064_seizures1.65043137
60MP0006072_abnormal_retinal_apoptosis1.62781530
61MP0002938_white_spotting1.61935099
62MP0004142_abnormal_muscle_tone1.61701837
63MP0005187_abnormal_penis_morphology1.59601264
64MP0002067_abnormal_sensory_capabilities1.56560069
65MP0005394_taste/olfaction_phenotype1.55254091
66MP0005499_abnormal_olfactory_system1.55254091
67MP0001440_abnormal_grooming_behavior1.54135770
68MP0005253_abnormal_eye_physiology1.53512181
69MP0002060_abnormal_skin_morphology1.50821119
70MP0002733_abnormal_thermal_nociception1.50797098
71MP0002233_abnormal_nose_morphology1.49536695
72MP0002557_abnormal_social/conspecific_i1.48150466
73MP0001340_abnormal_eyelid_morphology1.47333252
74MP0003315_abnormal_perineum_morphology1.45455257
75MP0001502_abnormal_circadian_rhythm1.45438910
76MP0005501_abnormal_skin_physiology1.43419344
77MP0010386_abnormal_urinary_bladder1.42099162
78MP0000427_abnormal_hair_cycle1.41076455
79MP0004811_abnormal_neuron_physiology1.41064353
80MP0000377_abnormal_hair_follicle1.41057269
81MP0002751_abnormal_autonomic_nervous1.40890090
82MP0000534_abnormal_ureter_morphology1.40070129
83MP0003879_abnormal_hair_cell1.39059380
84MP0002882_abnormal_neuron_morphology1.35949312
85MP0002177_abnormal_outer_ear1.32962108
86MP0005367_renal/urinary_system_phenotyp1.32877425
87MP0000516_abnormal_urinary_system1.32877425
88MP0002009_preneoplasia1.32787989
89MP0002282_abnormal_trachea_morphology1.30737828
90MP0006292_abnormal_olfactory_placode1.30445991
91MP0001486_abnormal_startle_reflex1.30325807
92MP0000467_abnormal_esophagus_morphology1.28435919
93MP0002102_abnormal_ear_morphology1.27253815
94MP0005645_abnormal_hypothalamus_physiol1.27113351
95MP0002160_abnormal_reproductive_system1.24880720
96MP0001270_distended_abdomen1.24618133
97MP0001216_abnormal_epidermal_layer1.24370469
98MP0002876_abnormal_thyroid_physiology1.22696643
99MP0001324_abnormal_eye_pigmentation1.21092140
100MP0002116_abnormal_craniofacial_bone1.19874248
101MP0003935_abnormal_craniofacial_develop1.19735909
102MP0005423_abnormal_somatic_nervous1.19307675
103MP0000778_abnormal_nervous_system1.17549679
104MP0005391_vision/eye_phenotype1.17546051
105MP0002822_catalepsy1.17417851
106MP0002697_abnormal_eye_size1.17403879
107MP0005647_abnormal_sex_gland1.17316440
108MP0005197_abnormal_uvea_morphology1.15441261
109MP0001188_hyperpigmentation1.12774050
110MP0005195_abnormal_posterior_eye1.11930686
111MP0002109_abnormal_limb_morphology1.11345115
112MP0002152_abnormal_brain_morphology1.09019781
113MP0010771_integument_phenotype1.08752503
114MP0005508_abnormal_skeleton_morphology1.07427819
115MP0005409_darkened_coat_color1.07285845
116MP0002932_abnormal_joint_morphology1.07065888
117MP0001299_abnormal_eye_distance/1.06458411
118MP0002108_abnormal_muscle_morphology1.06363480
119MP0006276_abnormal_autonomic_nervous1.05376298
120MP0002066_abnormal_motor_capabilities/c1.05070785
121MP0002184_abnormal_innervation1.03216757
122MP0000678_abnormal_parathyroid_gland1.02753859
123MP0000569_abnormal_digit_pigmentation1.01546503
124MP0008877_abnormal_DNA_methylation1.00745230
125MP0001293_anophthalmia0.98434803
126MP0009384_cardiac_valve_regurgitation0.97869980
127MP0003136_yellow_coat_color0.97330058
128MP0001963_abnormal_hearing_physiology0.96532830
129MP0001348_abnormal_lacrimal_gland0.96475280
130MP0001286_abnormal_eye_development0.96135620
131MP0004272_abnormal_basement_membrane0.95816800
132MP0000432_abnormal_head_morphology0.95592088
133MP0000428_abnormal_craniofacial_morphol0.94551158
134MP0000372_irregular_coat_pigmentation0.93280926
135MP0003890_abnormal_embryonic-extraembry0.89611618
136MP0003938_abnormal_ear_development0.89078497
137MP0004133_heterotaxia0.88347087
138MP0003633_abnormal_nervous_system0.87941301
139MP0003453_abnormal_keratinocyte_physiol0.87851845
140MP0002752_abnormal_somatic_nervous0.87184758
141MP0003861_abnormal_nervous_system0.87093739
142MP0008569_lethality_at_weaning0.86477948
143MP0002092_abnormal_eye_morphology0.82495541
144MP0003631_nervous_system_phenotype0.81706947
145MP0002069_abnormal_eating/drinking_beha0.81524917
146MP0002081_perinatal_lethality0.81443222
147MP0002229_neurodegeneration0.79978251
148MP0004145_abnormal_muscle_electrophysio0.79837481
149MP0002896_abnormal_bone_mineralization0.79784011
150MP0000631_abnormal_neuroendocrine_gland0.79121338
151MP0004858_abnormal_nervous_system0.78497494
152MP0002734_abnormal_mechanical_nocicepti0.77364399
153MP0000163_abnormal_cartilage_morphology0.76876095
154MP0002090_abnormal_vision0.76429486
155MP0000026_abnormal_inner_ear0.76345895
156MP0002166_altered_tumor_susceptibility0.76147248
157MP0001943_abnormal_respiration0.76110400
158MP0000627_abnormal_mammary_gland0.75463040
159MP0003948_abnormal_gas_homeostasis0.74283661
160MP0005257_abnormal_intraocular_pressure0.74092560
161MP0003646_muscle_fatigue0.72113254
162MP0001986_abnormal_taste_sensitivity0.64576024
163MP0003123_paternal_imprinting0.63784846
164MP0003634_abnormal_glial_cell0.63001479
165MP0003329_amyloid_beta_deposits0.61985816
166MP0004134_abnormal_chest_morphology0.54340816

Predicted human phenotypes

RankGene SetZ-score
1Focal seizures (HP:0007359)4.72458503
2Short 4th metacarpal (HP:0010044)4.62847998
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.62847998
4Congenital stationary night blindness (HP:0007642)4.57079110
5Chorioretinal atrophy (HP:0000533)4.47926301
6Abnormal rod and cone electroretinograms (HP:0008323)4.38467807
7Atonic seizures (HP:0010819)4.28444412
8Absent rod-and cone-mediated responses on ERG (HP:0007688)4.22273773
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.19968557
10Limb dystonia (HP:0002451)4.14219762
11Agitation (HP:0000713)4.03894919
12Bony spicule pigmentary retinopathy (HP:0007737)3.91619525
13Lip pit (HP:0100267)3.86761890
14Pendular nystagmus (HP:0012043)3.67757677
15Pheochromocytoma (HP:0002666)3.66272776
16Polyphagia (HP:0002591)3.63217202
17Abnormality of the 4th metacarpal (HP:0010012)3.53883688
18Myokymia (HP:0002411)3.47310704
19Fragile nails (HP:0001808)3.42500384
20Thoracic kyphosis (HP:0002942)3.36052699
21Hypotrichosis (HP:0001006)3.32641998
22Keratoconus (HP:0000563)3.27970151
23Increased corneal curvature (HP:0100692)3.27970151
24Genetic anticipation (HP:0003743)3.26045274
25Decreased central vision (HP:0007663)3.26039818
26Aplasia cutis congenita (HP:0001057)3.23720820
27Failure to thrive in infancy (HP:0001531)3.21063744
28Plantar hyperkeratosis (HP:0007556)3.17274643
29Onycholysis (HP:0001806)3.16120152
30Vitreoretinal degeneration (HP:0000655)3.12040445
31Neuroendocrine neoplasm (HP:0100634)3.02551833
32Narrow nasal bridge (HP:0000446)3.00396787
33Drooling (HP:0002307)2.99721286
34Oligodactyly (hands) (HP:0001180)2.96811987
35Stenosis of the external auditory canal (HP:0000402)2.96295829
36Cutaneous finger syndactyly (HP:0010554)2.95427727
37Hypothermia (HP:0002045)2.94550925
38Termporal pattern (HP:0011008)2.93056440
39Insidious onset (HP:0003587)2.93056440
40Milia (HP:0001056)2.92918698
41Absent eyebrow (HP:0002223)2.91245670
42Abnormality of the nasal septum (HP:0000419)2.89455388
43Microglossia (HP:0000171)2.89312253
44Broad-based gait (HP:0002136)2.88695804
45Abnormality of the parietal bone (HP:0002696)2.88219319
46Amblyopia (HP:0000646)2.81085262
47Abolished electroretinogram (ERG) (HP:0000550)2.80793912
48Ulnar claw (HP:0001178)2.79592717
49Thyroid-stimulating hormone excess (HP:0002925)2.76239164
50Excessive salivation (HP:0003781)2.75627535
51Severe visual impairment (HP:0001141)2.74497734
52Concave nail (HP:0001598)2.74218173
53Visual hallucinations (HP:0002367)2.71448208
54Midline defect of the nose (HP:0004122)2.70172613
55Restlessness (HP:0000711)2.68011718
56Patellar aplasia (HP:0006443)2.63040493
57Pigmentary retinal degeneration (HP:0001146)2.62951715
58Woolly hair (HP:0002224)2.62537322
59Generalized tonic-clonic seizures (HP:0002069)2.61045738
60Down-sloping shoulders (HP:0200021)2.60438824
61Focal motor seizures (HP:0011153)2.60172387
62Esotropia (HP:0000565)2.59308824
63Dialeptic seizures (HP:0011146)2.57770672
64Exostoses (HP:0100777)2.57259179
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.56935989
66Increased IgE level (HP:0003212)2.53632984
67Abnormality of hair growth rate (HP:0011363)2.52431399
68Slow-growing hair (HP:0002217)2.52431399
69Natal tooth (HP:0000695)2.52374252
70Cutaneous syndactyly (HP:0012725)2.52175481
71Short 5th finger (HP:0009237)2.52174701
72Morphological abnormality of the middle ear (HP:0008609)2.51989373
73Parakeratosis (HP:0001036)2.51432117
74Central scotoma (HP:0000603)2.47387368
75Atrophic scars (HP:0001075)2.47277839
76Febrile seizures (HP:0002373)2.44956909
77Short middle phalanx of the 5th finger (HP:0004220)2.43459988
78Aplasia/Hypoplasia of the patella (HP:0006498)2.42723480
79Attenuation of retinal blood vessels (HP:0007843)2.41867400
80Diastasis recti (HP:0001540)2.40489559
81Palmoplantar hyperkeratosis (HP:0000972)2.39636793
82Sparse scalp hair (HP:0002209)2.39228005
83Abnormality of the corticospinal tract (HP:0002492)2.38603569
84Abnormality of the intervertebral disk (HP:0005108)2.35439168
85Oligodontia (HP:0000677)2.34755455
86Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.31529860
87Palmar hyperkeratosis (HP:0010765)2.30742062
88Anophthalmia (HP:0000528)2.27339277
89Hyperthyroidism (HP:0000836)2.25974237
90Hypoplasia of the brainstem (HP:0002365)2.25218057
91Aplasia/Hypoplasia of the brainstem (HP:0007362)2.25218057
92Hip dysplasia (HP:0001385)2.25134691
93Action tremor (HP:0002345)2.23954663
94Absence seizures (HP:0002121)2.23907542
95Abnormality of the nasolacrimal system (HP:0000614)2.22320978
96Macular degeneration (HP:0000608)2.21256184
97Abnormality of macular pigmentation (HP:0008002)2.20299176
98Abnormality of the lacrimal duct (HP:0011481)2.18730863
99Aplasia of the musculature (HP:0100854)2.18718597
100Abnormality of the thoracic spine (HP:0100711)2.17629810
101Spina bifida occulta (HP:0003298)2.17491001
102Dyschromatopsia (HP:0007641)2.16693206
103Ridged nail (HP:0001807)2.15464078
104Urinary bladder sphincter dysfunction (HP:0002839)2.15190299
105High anterior hairline (HP:0009890)2.14995667
106Congenital sensorineural hearing impairment (HP:0008527)2.13101726
107Mixed hearing impairment (HP:0000410)2.12217274
108Abnormality of the 2nd finger (HP:0004100)2.12098970
109Split foot (HP:0001839)2.11734523
110Shawl scrotum (HP:0000049)2.11484095
111Peripheral hypomyelination (HP:0007182)2.11246692
112Labial hypoplasia (HP:0000066)2.09794720
113Pachygyria (HP:0001302)2.09738773
114Protruding tongue (HP:0010808)2.07554054
115Inappropriate behavior (HP:0000719)2.06872921
116White forelock (HP:0002211)2.06454247
117Increased cerebral lipofuscin (HP:0011813)2.06114596
118Advanced eruption of teeth (HP:0006288)2.05574339
119Severe Myopia (HP:0011003)2.04666862
120Absent epiphyses (HP:0010577)2.04240322
121Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04240322
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01961699
123Oligodactyly (HP:0012165)2.00848729
124Nasolacrimal duct obstruction (HP:0000579)2.00756080
125Cerebral hemorrhage (HP:0001342)2.00687775
126Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.00054115
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96882979
128Torticollis (HP:0000473)1.96580679
129Myelomeningocele (HP:0002475)1.96006810
130Wide cranial sutures (HP:0010537)1.95891732
131Abnormality of salivation (HP:0100755)1.94750690
132Popliteal pterygium (HP:0009756)1.94497719
133Broad distal phalanx of finger (HP:0009836)1.92486879
134Metabolic alkalosis (HP:0200114)1.90369904
135Vertebral arch anomaly (HP:0008438)1.89772578
136Renal hypoplasia (HP:0000089)1.89187173
137Photophobia (HP:0000613)1.88869034
138Scotoma (HP:0000575)1.88536323
139Fragile skin (HP:0001030)1.87560059
140Partial agenesis of the corpus callosum (HP:0001338)1.86809295
141Abnormal eating behavior (HP:0100738)1.85366803
142Heterochromia iridis (HP:0001100)1.85131382
143Pancreatic cysts (HP:0001737)1.85071388
144Status epilepticus (HP:0002133)1.84231894
145Pili torti (HP:0003777)1.84146399
146Prolonged QT interval (HP:0001657)1.84048305
147Cone-rod dystrophy (HP:0000548)1.83689124
14811 pairs of ribs (HP:0000878)1.83193678
149Atelectasis (HP:0100750)1.83053124
150Renal dysplasia (HP:0000110)1.83000304
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.81498106
152Hypoplastic female external genitalia (HP:0012815)1.81407309
153* Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80435576
154Poor speech (HP:0002465)1.80233819
155Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79993838
156Exotropia (HP:0000577)1.78355390
157Back pain (HP:0003418)1.77246372
158Hypoplastic labia majora (HP:0000059)1.76035413
159Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75574065
160Macroorchidism (HP:0000053)1.75547711
161Short clavicles (HP:0000894)1.74750432
162Irregular vertebral endplates (HP:0003301)1.74062065
163Asymmetry of the thorax (HP:0001555)1.73921356
164Anhidrosis (HP:0000970)1.73150374
165Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72967043
166Supernumerary ribs (HP:0005815)1.72936325
167Hyperventilation (HP:0002883)1.72146567
168Hypodontia (HP:0000668)1.72126916
169Disinhibition (HP:0000734)1.70880497
170Abnormality of the labia minora (HP:0012880)1.68406273
171Patchy hypopigmentation of hair (HP:0011365)1.67934398
172Myotonia (HP:0002486)1.67850527
173Trigonocephaly (HP:0000243)1.66807683
174Hypoventilation (HP:0002791)1.66696565
175Spinal muscular atrophy (HP:0007269)1.66585137
176Apathy (HP:0000741)1.65789446
177Absent eyelashes (HP:0000561)1.65556401
178Hypsarrhythmia (HP:0002521)1.65115705
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.64351249
180Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.63997156
181Degeneration of the lateral corticospinal tracts (HP:0002314)1.63997156
182* Abnormality of the phalanges of the 5th finger (HP:0004213)1.63427515
183Ureteral obstruction (HP:0006000)1.62100101
184Esophageal atresia (HP:0002032)1.60791049
185Abnormality of the aortic arch (HP:0012303)1.60748254
186Abnormality of the phalanges of the hallux (HP:0010057)1.59583358
187Abnormality of the middle phalanges of the toes (HP:0010183)1.57956101
188Bifid scrotum (HP:0000048)1.56991297
189Ureteral stenosis (HP:0000071)1.56094315
190Increased number of teeth (HP:0011069)1.54860479
191Type II diabetes mellitus (HP:0005978)1.54827695
192Abnormality of the labia majora (HP:0012881)1.54197763
193Erythema (HP:0010783)1.53877566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D5.01329627
2EPHA34.61933005
3LATS14.15680430
4EPHB23.49081544
5ERBB33.28255826
6MAP3K92.78525846
7CASK2.61415244
8DYRK1B2.25954120
9SIK32.12290081
10GRK12.11142131
11SIK12.02210469
12DYRK31.97334448
13ERBB21.94393973
14SGK21.87787623
15MARK11.87686144
16STK38L1.73729399
17FGFR21.70062336
18WNK31.68281722
19MST1R1.66757141
20BMPR1B1.66230390
21LATS21.58603674
22AKT31.57741193
23NTRK21.57182724
24BCR1.54341735
25SGK4941.48232179
26SGK2231.48232179
27CDK31.48093813
28FER1.45232934
29DYRK1A1.43934435
30NTRK11.40539111
31MAP2K71.34897370
32TNIK1.34853659
33MKNK11.34270098
34PNCK1.33762516
35PAK31.27455621
36MAPK131.27198315
37PHKG21.24497559
38PHKG11.24497559
39ICK1.23082317
40PRPF4B1.15991488
41ADRBK11.15757046
42MAP2K41.14853811
43SGK31.14472091
44MAP3K141.14140434
45CDK51.13602229
46PRKCG1.13593452
47TYRO31.11491691
48CAMK11.05672874
49INSRR1.01950121
50PLK20.98777153
51DYRK20.97834440
52UHMK10.96491541
53PAK60.96437380
54STK240.96246812
55PKN20.94704652
56STK30.94369124
57MATK0.94132720
58ADRBK20.93812828
59MARK20.93034685
60MKNK20.92813686
61CHUK0.91676193
62HIPK20.89559739
63CAMKK10.86953341
64MAP3K40.85263887
65CDC42BPA0.84495597
66BRAF0.83907921
67PRKCE0.83596083
68PRKD20.83133634
69WNK10.78611972
70TRIB30.77607416
71DDR20.77262154
72BMPR20.76966000
73WNK40.72950104
74OXSR10.72869974
75FGFR30.72759570
76GRK70.70605908
77CDK190.70285607
78PRKCH0.70172691
79TGFBR10.69280032
80NLK0.68019398
81PDGFRA0.67743167
82CSNK1E0.65735849
83NUAK10.65168088
84PRKCI0.62780801
85CDK140.61399917
86RPS6KA20.59975690
87CAMK2B0.59209761
88EIF2AK20.58368055
89NEK90.58186786
90CDK150.57609750
91PRKAA10.56648072
92CDK180.56273859
93CSNK1A1L0.56043302
94CDK11A0.55180085
95CAMK1G0.55013322
96ROCK10.53554123
97PTK60.52868875
98GRK50.52798801
99KSR10.52404982
100MAPK80.52067305
101RPS6KL10.51616551
102RPS6KC10.51616551
103CSNK1G10.51574728
104RPS6KA60.51326584
105FGFR10.50436719
106CSNK1A10.50313049
107MAP3K60.49023999
108ARAF0.48881782
109IRAK20.48514746
110PLK30.47714052
111PINK10.45231327
112CAMKK20.45137463
113MAPK90.44405938
114SGK10.44233949
115MET0.43777763
116FRK0.43744668
117CAMK40.43569354
118STK380.43542422
119SIK20.42667270
120CSNK1G20.42645204
121CSNK1G30.42211571
122RPS6KB20.41860338
123MINK10.40215145
124CAMK2A0.39931795
125PRKCZ0.38346995
126MAP3K30.38023648
127PRKACA0.36850767
128BRD40.35108341
129MAPK30.34248900
130MAPK140.34221691
131CHEK20.33971841
132RPS6KA30.33831836
133MAP2K20.33542345
134ZAK0.33509444
135PKN10.33413440
136PRKG10.33171298
137MAPKAPK50.33103039
138CDK80.32838317
139AKT10.32620704
140CSNK1D0.32481059
141TRPM70.32259559
142GSK3B0.32172585
143CDK120.31960499
144PRKD30.31247853
145ABL20.30271639
146CAMK2G0.27704395
147RPS6KA10.27644266
148CAMK2D0.26672404
149MTOR0.25590480

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.22608190
2Basal cell carcinoma_Homo sapiens_hsa052173.50187007
3Hedgehog signaling pathway_Homo sapiens_hsa043402.50013599
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.17926427
5Hippo signaling pathway_Homo sapiens_hsa043902.10285506
6Axon guidance_Homo sapiens_hsa043602.07388019
7Wnt signaling pathway_Homo sapiens_hsa043101.95721677
8Cyanoamino acid metabolism_Homo sapiens_hsa004601.86249328
9Cardiac muscle contraction_Homo sapiens_hsa042601.81294143
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.77531746
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74299249
12Adherens junction_Homo sapiens_hsa045201.64587292
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64048063
14Melanogenesis_Homo sapiens_hsa049161.61070513
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.55592362
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53273839
17Histidine metabolism_Homo sapiens_hsa003401.49905705
18Long-term potentiation_Homo sapiens_hsa047201.48034135
19Endometrial cancer_Homo sapiens_hsa052131.44695506
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34177433
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32908409
22Renal cell carcinoma_Homo sapiens_hsa052111.32502637
23Dorso-ventral axis formation_Homo sapiens_hsa043201.31985455
24Phenylalanine metabolism_Homo sapiens_hsa003601.30477898
25Olfactory transduction_Homo sapiens_hsa047401.26411139
26Serotonergic synapse_Homo sapiens_hsa047261.24590096
27TGF-beta signaling pathway_Homo sapiens_hsa043501.21987706
28Collecting duct acid secretion_Homo sapiens_hsa049661.21391750
29Synaptic vesicle cycle_Homo sapiens_hsa047211.17962766
30Circadian entrainment_Homo sapiens_hsa047131.14404270
31Cholinergic synapse_Homo sapiens_hsa047251.12795494
32Tyrosine metabolism_Homo sapiens_hsa003501.10062143
33MicroRNAs in cancer_Homo sapiens_hsa052061.09889509
34ECM-receptor interaction_Homo sapiens_hsa045121.09532401
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09257324
36Nicotine addiction_Homo sapiens_hsa050331.08803986
37Proteoglycans in cancer_Homo sapiens_hsa052051.04355554
38Amphetamine addiction_Homo sapiens_hsa050311.01467681
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.00438945
40Melanoma_Homo sapiens_hsa052180.99769080
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99325327
42Pathways in cancer_Homo sapiens_hsa052000.99097080
43Notch signaling pathway_Homo sapiens_hsa043300.98756775
44Colorectal cancer_Homo sapiens_hsa052100.97059095
45Glutamatergic synapse_Homo sapiens_hsa047240.96746802
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95621603
47Cocaine addiction_Homo sapiens_hsa050300.94633320
48Caffeine metabolism_Homo sapiens_hsa002320.92757241
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92222355
50Linoleic acid metabolism_Homo sapiens_hsa005910.91540885
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90886133
52Type II diabetes mellitus_Homo sapiens_hsa049300.90612471
53Salivary secretion_Homo sapiens_hsa049700.90439820
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89540839
55Dopaminergic synapse_Homo sapiens_hsa047280.88775362
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88260882
57Regulation of autophagy_Homo sapiens_hsa041400.87072487
58Long-term depression_Homo sapiens_hsa047300.87058582
59Taste transduction_Homo sapiens_hsa047420.82824821
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82313890
61Protein digestion and absorption_Homo sapiens_hsa049740.80909712
62Ras signaling pathway_Homo sapiens_hsa040140.80702971
63Ovarian steroidogenesis_Homo sapiens_hsa049130.80609592
64Tight junction_Homo sapiens_hsa045300.78716742
65GABAergic synapse_Homo sapiens_hsa047270.78503258
66Rap1 signaling pathway_Homo sapiens_hsa040150.76966044
67Renin secretion_Homo sapiens_hsa049240.76588815
68Basal transcription factors_Homo sapiens_hsa030220.75461226
69Dilated cardiomyopathy_Homo sapiens_hsa054140.75263347
70Gastric acid secretion_Homo sapiens_hsa049710.73094170
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72115448
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71884005
73ErbB signaling pathway_Homo sapiens_hsa040120.71852109
74Gap junction_Homo sapiens_hsa045400.71451459
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71150336
76Prostate cancer_Homo sapiens_hsa052150.70982764
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70973705
78Circadian rhythm_Homo sapiens_hsa047100.70368927
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67167951
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67114394
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66680040
82Arachidonic acid metabolism_Homo sapiens_hsa005900.66366455
83cAMP signaling pathway_Homo sapiens_hsa040240.64676581
84Vibrio cholerae infection_Homo sapiens_hsa051100.64628757
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63243332
86GnRH signaling pathway_Homo sapiens_hsa049120.63139664
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63070449
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62931145
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62802123
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62595634
91HTLV-I infection_Homo sapiens_hsa051660.62142450
92Butanoate metabolism_Homo sapiens_hsa006500.61676315
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61269286
94Focal adhesion_Homo sapiens_hsa045100.60847269
95MAPK signaling pathway_Homo sapiens_hsa040100.60785182
96Morphine addiction_Homo sapiens_hsa050320.60763906
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60639631
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60137774
99Calcium signaling pathway_Homo sapiens_hsa040200.59989924
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.59488719
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59443928
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59010396
103Lysine degradation_Homo sapiens_hsa003100.58748991
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57753244
105Small cell lung cancer_Homo sapiens_hsa052220.55031526
106AMPK signaling pathway_Homo sapiens_hsa041520.54643534
107Thyroid cancer_Homo sapiens_hsa052160.53839345
108Glioma_Homo sapiens_hsa052140.51844963
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51826786
110Sphingolipid metabolism_Homo sapiens_hsa006000.51757449
111Amoebiasis_Homo sapiens_hsa051460.51691364
112Ether lipid metabolism_Homo sapiens_hsa005650.51269868
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50502062
114VEGF signaling pathway_Homo sapiens_hsa043700.49573142
115Pancreatic secretion_Homo sapiens_hsa049720.48814271
116Choline metabolism in cancer_Homo sapiens_hsa052310.48730294
117Alcoholism_Homo sapiens_hsa050340.48412510
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47587569
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47302742
120Pancreatic cancer_Homo sapiens_hsa052120.46717973
121Insulin secretion_Homo sapiens_hsa049110.46623063
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.45258996
123Oxytocin signaling pathway_Homo sapiens_hsa049210.44481642
124Prolactin signaling pathway_Homo sapiens_hsa049170.44003602
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43925758
126FoxO signaling pathway_Homo sapiens_hsa040680.43276504
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43165891
128Retinol metabolism_Homo sapiens_hsa008300.42821817
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42648479
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.42555980
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38873535
132Thyroid hormone synthesis_Homo sapiens_hsa049180.38054946

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