TFAP2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.89854390
2cornea development in camera-type eye (GO:0061303)5.85905396
3ribosome assembly (GO:0042255)5.09226135
4mitotic metaphase plate congression (GO:0007080)4.78275548
5purine nucleobase biosynthetic process (GO:0009113)4.69354917
6regulation of cell proliferation involved in kidney development (GO:1901722)4.65242091
7formation of translation preinitiation complex (GO:0001731)4.62430314
8nucleobase biosynthetic process (GO:0046112)4.54031029
9regulation of water loss via skin (GO:0033561)4.37583519
10establishment of skin barrier (GO:0061436)4.22832418
11negative regulation of keratinocyte proliferation (GO:0010839)4.19268181
12interferon-gamma secretion (GO:0072643)4.13673525
13ribosome biogenesis (GO:0042254)4.09272645
14maturation of SSU-rRNA (GO:0030490)4.08788282
15protein localization to kinetochore (GO:0034501)3.95701176
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.95078745
17regulation of gene silencing by RNA (GO:0060966)3.95059035
18regulation of posttranscriptional gene silencing (GO:0060147)3.95059035
19regulation of gene silencing by miRNA (GO:0060964)3.95059035
20DNA replication checkpoint (GO:0000076)3.94384505
21mitotic nuclear envelope disassembly (GO:0007077)3.93555788
22ER overload response (GO:0006983)3.93510164
23regulation of spindle organization (GO:0090224)3.93459079
24* keratinocyte development (GO:0003334)3.86490832
25metaphase plate congression (GO:0051310)3.85295929
26folic acid metabolic process (GO:0046655)3.82372302
27intestinal epithelial cell development (GO:0060576)3.78341412
28nuclear pore organization (GO:0006999)3.76673337
29nuclear envelope disassembly (GO:0051081)3.70989728
30membrane disassembly (GO:0030397)3.70989728
31lung-associated mesenchyme development (GO:0060484)3.69023835
32positive regulation of chromosome segregation (GO:0051984)3.64542055
33mitotic sister chromatid segregation (GO:0000070)3.61099993
34DNA replication initiation (GO:0006270)3.58787220
35polarized epithelial cell differentiation (GO:0030859)3.57506414
36histone H2A monoubiquitination (GO:0035518)3.57155650
37ribonucleoprotein complex biogenesis (GO:0022613)3.52891835
38bundle of His cell to Purkinje myocyte communication (GO:0086069)3.52374016
39cell differentiation involved in embryonic placenta development (GO:0060706)3.49511726
40DNA replication-dependent nucleosome organization (GO:0034723)3.48575846
41DNA replication-dependent nucleosome assembly (GO:0006335)3.48575846
42ear development (GO:0043583)3.44971702
43epithelial cell maturation (GO:0002070)3.38420131
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38352459
45paraxial mesoderm development (GO:0048339)3.35811705
46regulation of mitotic spindle organization (GO:0060236)3.35210613
47protein localization to chromosome, centromeric region (GO:0071459)3.34997559
48limb bud formation (GO:0060174)3.34365229
49blastocyst development (GO:0001824)3.33908014
50nuclear pore complex assembly (GO:0051292)3.32173351
51notochord development (GO:0030903)3.32099325
52* trophectodermal cell differentiation (GO:0001829)3.30333917
53cardiac right ventricle morphogenesis (GO:0003215)3.30222880
54regulation of keratinocyte differentiation (GO:0045616)3.30010338
55positive regulation of keratinocyte differentiation (GO:0045618)3.27443003
56lateral sprouting from an epithelium (GO:0060601)3.26686142
57otic vesicle formation (GO:0030916)3.25210763
58ribosomal large subunit biogenesis (GO:0042273)3.23616491
59negative regulation of epidermal cell differentiation (GO:0045605)3.22522184
60regulation of keratinocyte proliferation (GO:0010837)3.22303460
61negative regulation of chromosome segregation (GO:0051985)3.20895166
62rRNA processing (GO:0006364)3.20641576
63regulation of translational termination (GO:0006449)3.20621295
64regulation of chromosome segregation (GO:0051983)3.18989222
65spindle checkpoint (GO:0031577)3.18496915
66DNA strand elongation involved in DNA replication (GO:0006271)3.18312777
67dorsal/ventral axis specification (GO:0009950)3.18072471
68mitotic spindle checkpoint (GO:0071174)3.17093666
69establishment of chromosome localization (GO:0051303)3.15837703
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.14683267
71regulation of telomere maintenance via telomerase (GO:0032210)3.13609360
72rRNA modification (GO:0000154)3.13474296
73nuclear envelope organization (GO:0006998)3.11857425
74rRNA metabolic process (GO:0016072)3.11234124
75histone H4-K12 acetylation (GO:0043983)3.10974304
76eyelid development in camera-type eye (GO:0061029)3.09684627
77negative regulation of mitotic sister chromatid separation (GO:2000816)3.08359248
78negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08359248
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08359248
80negative regulation of sister chromatid segregation (GO:0033046)3.08359248
81regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.06860370
82sister chromatid segregation (GO:0000819)3.06614301
83mitotic spindle assembly checkpoint (GO:0007094)3.06254039
84regulation of centriole replication (GO:0046599)3.03957738
85folic acid-containing compound biosynthetic process (GO:0009396)3.03848271
86regulation of centrosome cycle (GO:0046605)3.03781698
87lens development in camera-type eye (GO:0002088)3.03157464
88branching involved in labyrinthine layer morphogenesis (GO:0060670)3.02524165
89protein K6-linked ubiquitination (GO:0085020)3.01676614
90regulation of translation in response to stress (GO:0043555)3.01418413
91spindle assembly checkpoint (GO:0071173)3.01224915
92DNA strand elongation (GO:0022616)3.01125941
93regulation of tight junction assembly (GO:2000810)3.00951284
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00877881
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00244611
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.00244611
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97223610
98translational initiation (GO:0006413)2.95497469
99IMP biosynthetic process (GO:0006188)2.95433469
100gap junction assembly (GO:0016264)2.94282226
101maturation of 5.8S rRNA (GO:0000460)2.94130029
102sympathetic nervous system development (GO:0048485)2.93200795
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91695637
104mitotic G1 DNA damage checkpoint (GO:0031571)2.90574365
105mitotic chromosome condensation (GO:0007076)2.88933841
106attachment of spindle microtubules to kinetochore (GO:0008608)2.88458644
107DNA unwinding involved in DNA replication (GO:0006268)2.87835114
108regulation of histone H3-K27 methylation (GO:0061085)2.86633153
109histone arginine methylation (GO:0034969)2.86259731
110DNA double-strand break processing (GO:0000729)2.85165477
111regulation of helicase activity (GO:0051095)2.84741705
112proteasome assembly (GO:0043248)2.84614967
113histone H2A ubiquitination (GO:0033522)2.83592031
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83405942
115trophoblast giant cell differentiation (GO:0060707)2.82570770
116tight junction assembly (GO:0070830)2.81878437
117branching involved in salivary gland morphogenesis (GO:0060445)2.81609538
118nephron tubule formation (GO:0072079)2.81485188
119spliceosomal snRNP assembly (GO:0000387)2.81130342
120regulation of hippo signaling (GO:0035330)2.81111609
121negative regulation of epidermis development (GO:0045683)2.80221327
122regulation of mitotic sister chromatid separation (GO:0010965)2.79967315
123regulation of mitotic sister chromatid segregation (GO:0033047)2.79967315
124regulation of sister chromatid segregation (GO:0033045)2.79967315
125negative regulation of histone methylation (GO:0031061)2.78355609
126kinetochore assembly (GO:0051382)2.75308494
127regulation of sister chromatid cohesion (GO:0007063)2.73764332
128cranial suture morphogenesis (GO:0060363)2.72615054
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.72193866
130white fat cell differentiation (GO:0050872)2.72012166
131chaperone-mediated protein complex assembly (GO:0051131)2.71845412
132protein localization to chromosome (GO:0034502)2.71649709
133ribosomal small subunit biogenesis (GO:0042274)2.71648309
134transcription from RNA polymerase I promoter (GO:0006360)2.71509798
135negative regulation of translational initiation (GO:0045947)2.71258980
136positive regulation of mitotic sister chromatid separation (GO:1901970)2.69711819
137positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69711819
138replication fork processing (GO:0031297)2.69083040
139spindle assembly involved in mitosis (GO:0090307)2.69051035
140anterior/posterior axis specification, embryo (GO:0008595)2.65724563
141keratinization (GO:0031424)2.65438033
142kinetochore organization (GO:0051383)2.64387117
143positive regulation of epidermal cell differentiation (GO:0045606)2.63706611
144lung lobe morphogenesis (GO:0060463)2.63265027
145prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.62812266
146pyrimidine-containing compound transmembrane transport (GO:0072531)2.61598921
147prostate gland growth (GO:0060736)2.61547514
148TOR signaling (GO:0031929)2.61529024
149regulation of DNA endoreduplication (GO:0032875)2.60483797
150establishment of tissue polarity (GO:0007164)2.59840076
151establishment of planar polarity (GO:0001736)2.59840076
152epithelial tube branching involved in lung morphogenesis (GO:0060441)2.59511238
153ectoderm development (GO:0007398)2.58972392
154face development (GO:0060324)2.57666563
155embryonic camera-type eye development (GO:0031076)2.57406283
156negative regulation of kidney development (GO:0090185)2.57258442
157morphogenesis of embryonic epithelium (GO:0016331)2.56941810
158multicellular organismal water homeostasis (GO:0050891)2.55836333
159embryonic cranial skeleton morphogenesis (GO:0048701)2.54308597
160regulation of epidermal cell differentiation (GO:0045604)2.52797499
161regulation of timing of cell differentiation (GO:0048505)2.51466861
162NLS-bearing protein import into nucleus (GO:0006607)2.51083197
163purine ribonucleotide transport (GO:0015868)2.48994335
164artery development (GO:0060840)2.47042423
165diterpenoid biosynthetic process (GO:0016102)2.45973118
166negative regulation of dendrite morphogenesis (GO:0050774)2.44472718
167embryonic body morphogenesis (GO:0010172)2.44034391
168regulation of centrosome duplication (GO:0010824)2.44021140
169keratinocyte differentiation (GO:0030216)2.44019841
170glandular epithelial cell differentiation (GO:0002067)2.42370005
171adenine nucleotide transport (GO:0051503)2.40336599
172calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.39915293
173viral mRNA export from host cell nucleus (GO:0046784)2.39644366
174apical protein localization (GO:0045176)2.36880776
175embryonic camera-type eye morphogenesis (GO:0048596)2.36531191
176columnar/cuboidal epithelial cell development (GO:0002066)2.31205076
177regulation of glomerulus development (GO:0090192)2.30849530
178heart valve morphogenesis (GO:0003179)2.29357725
179regulation of mesenchymal cell apoptotic process (GO:2001053)2.29060462
180regulation of glomerular filtration (GO:0003093)2.28095164
181positive regulation of neuroblast proliferation (GO:0002052)2.27979485
182negative regulation of transcription by competitive promoter binding (GO:0010944)2.27202200
183cell-cell junction assembly (GO:0007043)2.27058734
184regulation of development, heterochronic (GO:0040034)2.24967886
185positive regulation of epidermis development (GO:0045684)2.24615822
186neural crest cell development (GO:0014032)2.23024031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.36800578
2ESR1_21235772_ChIP-Seq_MCF-7_Human4.84211628
3ESR1_20079471_ChIP-ChIP_T-47D_Human4.33194083
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.95859586
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.88842004
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.52025628
7* ESR2_21235772_ChIP-Seq_MCF-7_Human3.41819291
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28338070
9* AHR_22903824_ChIP-Seq_MCF-7_Human3.02176610
10* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.99699636
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76944070
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74681950
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71192399
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68024353
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.65724890
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.61480442
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.61480442
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.61480442
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58499369
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48551751
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.42448193
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.39810436
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.38367440
24* ARNT_22903824_ChIP-Seq_MCF-7_Human2.36205065
25* ESR1_15608294_ChIP-ChIP_MCF-7_Human2.35762256
26ZNF263_19887448_ChIP-Seq_K562_Human2.26135167
27AR_21909140_ChIP-Seq_LNCAP_Human2.25617115
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25169991
29* GATA3_24758297_ChIP-Seq_MCF-7_Human2.24575175
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23212191
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.18811369
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16290537
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.13702982
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.12097038
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11413734
36PKCTHETA_26484144_Chip-Seq_BREAST_Human2.06271778
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.05440796
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04655385
39TCF3_18692474_ChIP-Seq_MEFs_Mouse2.04301744
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03349320
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02790191
42STAT3_1855785_ChIP-Seq_MESCs_Mouse2.01940789
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01571940
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.99664987
45* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.99405915
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97851399
47XRN2_22483619_ChIP-Seq_HELA_Human1.96474917
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91183555
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.91181332
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85638020
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84049187
52ELF5_23300383_ChIP-Seq_T47D_Human1.82394545
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82354805
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81486110
55* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79841018
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79094161
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78294070
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74727253
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.74282629
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.68936451
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.68501469
62* RUNX1_27514584_Chip-Seq_MCF-7_Human1.64834371
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62812924
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58726705
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58333385
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57290495
67VDR_23849224_ChIP-Seq_CD4+_Human1.56967586
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.54769314
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51197190
70* E2F1_21310950_ChIP-Seq_MCF-7_Human1.50642173
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.50332821
72TTF2_22483619_ChIP-Seq_HELA_Human1.49632311
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48836969
74DCP1A_22483619_ChIP-Seq_HELA_Human1.47780043
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47342660
76GABP_19822575_ChIP-Seq_HepG2_Human1.44773664
77* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44097442
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43309014
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.42699583
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42096636
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.39393220
82KDM5A_27292631_Chip-Seq_BREAST_Human1.39169783
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39045685
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.38080108
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.36936526
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36788222
87NANOG_18692474_ChIP-Seq_MEFs_Mouse1.33106356
88* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33048240
89* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33048240
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32440670
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31047686
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30859808
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30679724
94* NANOG_16153702_ChIP-ChIP_HESCs_Human1.30623411
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30144463
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29191564
97* GATA6_25053715_ChIP-Seq_YYC3_Human1.27670968
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26902657
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22506549
100FOXP3_21729870_ChIP-Seq_TREG_Human1.21755587
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17470645
102SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17379957
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16554105
104MYC_22102868_ChIP-Seq_BL_Human1.15109746
105NANOG_18692474_ChIP-Seq_MESCs_Mouse1.14835078
106POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14747362
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14400424
108* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14044309
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13668302
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.13037452
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12303733
112POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11805864
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11653164
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11590561
115* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11396203
116* HOXB7_26014856_ChIP-Seq_BT474_Human1.10691891
117FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10274505
118* ER_23166858_ChIP-Seq_MCF-7_Human1.09964939
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07376704
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07058281
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06907666
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06863793
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06299939
124FOXO3_23340844_ChIP-Seq_DLD1_Human1.04943767
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04531108
126* SOX2_16153702_ChIP-ChIP_HESCs_Human1.03726921
127CDX2_20551321_ChIP-Seq_CACO-2_Human1.03470255
128RACK7_27058665_Chip-Seq_MCF-7_Human1.02863619
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02802875
130KAP1_27257070_Chip-Seq_ESCs_Mouse1.02714020
131ATF3_27146783_Chip-Seq_COLON_Human1.02555928
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01977524
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00785633
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99404467
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98903670
136GATA4_25053715_ChIP-Seq_YYC3_Human0.98405197
137CHD1_26751641_Chip-Seq_LNCaP_Human0.98209767
138HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95394137
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94299543
140CIITA_25753668_ChIP-Seq_RAJI_Human0.93302469
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93129810
142MYC_18940864_ChIP-ChIP_HL60_Human0.92080883
143TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91664174
144FUS_26573619_Chip-Seq_HEK293_Human0.90819302
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.90282403
146TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89178399
147SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88812671
148KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88383319
149ELK1_19687146_ChIP-ChIP_HELA_Human0.87827232
150TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87800360
151TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87711607
152EWS_26573619_Chip-Seq_HEK293_Human0.87483542
153TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85324706
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83150493
155CJUN_26792858_Chip-Seq_BT549_Human0.81266327
156FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79891990
157SOX17_20123909_ChIP-Seq_XEN_Mouse0.79800635
158P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79081630
159SOX2_20726797_ChIP-Seq_SW620_Human0.78383844
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.77111695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.54602511
2MP0004957_abnormal_blastocyst_morpholog3.84981225
3MP0003111_abnormal_nucleus_morphology3.79628446
4MP0006292_abnormal_olfactory_placode3.35832942
5MP0010094_abnormal_chromosome_stability3.18934075
6MP0003077_abnormal_cell_cycle3.01066589
7MP0003123_paternal_imprinting2.79021183
8MP0008057_abnormal_DNA_replication2.72405734
9MP0010352_gastrointestinal_tract_polyps2.58988804
10MP0010234_abnormal_vibrissa_follicle2.51863216
11MP0000427_abnormal_hair_cycle2.51376999
12MP0003718_maternal_effect2.48401329
13MP0002796_impaired_skin_barrier2.43527177
14MP0004264_abnormal_extraembryonic_tissu2.38697378
15MP0003941_abnormal_skin_development2.36492117
16MP0008932_abnormal_embryonic_tissue2.31379497
17MP0003705_abnormal_hypodermis_morpholog2.26286748
18MP0001730_embryonic_growth_arrest2.25992128
19MP0008789_abnormal_olfactory_epithelium2.23771170
20MP0005257_abnormal_intraocular_pressure2.19151314
21MP0002653_abnormal_ependyma_morphology2.09211498
22MP0000350_abnormal_cell_proliferation2.01888866
23MP0001672_abnormal_embryogenesis/_devel1.99436878
24MP0005380_embryogenesis_phenotype1.99436878
25MP0008058_abnormal_DNA_repair1.97137455
26MP0002160_abnormal_reproductive_system1.93489452
27MP0003567_abnormal_fetal_cardiomyocyte1.91099423
28MP0002938_white_spotting1.88778094
29MP0005670_abnormal_white_adipose1.86019057
30MP0002086_abnormal_extraembryonic_tissu1.84578223
31MP0008007_abnormal_cellular_replicative1.82099836
32MP0002084_abnormal_developmental_patter1.79286034
33MP0001697_abnormal_embryo_size1.78657443
34MP0001346_abnormal_lacrimal_gland1.77372233
35MP0003566_abnormal_cell_adhesion1.77141534
36MP0003984_embryonic_growth_retardation1.76972463
37MP0002088_abnormal_embryonic_growth/wei1.75425888
38MP0005501_abnormal_skin_physiology1.73864786
39MP0002085_abnormal_embryonic_tissue1.69654650
40MP0005076_abnormal_cell_differentiation1.67989546
41MP0000613_abnormal_salivary_gland1.63888086
42MP0002282_abnormal_trachea_morphology1.63461714
43MP0009384_cardiac_valve_regurgitation1.63290140
44MP0001849_ear_inflammation1.63121447
45MP0003786_premature_aging1.60917705
46MP0005248_abnormal_Harderian_gland1.58400834
47MP0004197_abnormal_fetal_growth/weight/1.58043211
48MP0010678_abnormal_skin_adnexa1.54024679
49MP0002080_prenatal_lethality1.53529056
50MP0000579_abnormal_nail_morphology1.52662674
51MP0000383_abnormal_hair_follicle1.52544282
52MP0003453_abnormal_keratinocyte_physiol1.49731680
53MP0005408_hypopigmentation1.49234242
54MP0003119_abnormal_digestive_system1.46955712
55MP0005646_abnormal_pituitary_gland1.44205000
56MP0005394_taste/olfaction_phenotype1.42497080
57MP0005499_abnormal_olfactory_system1.42497080
58MP0010307_abnormal_tumor_latency1.40719004
59MP0000049_abnormal_middle_ear1.37691002
60MP0003136_yellow_coat_color1.36538680
61MP0000647_abnormal_sebaceous_gland1.35456057
62MP0002254_reproductive_system_inflammat1.31602143
63MP0004782_abnormal_surfactant_physiolog1.30949947
64MP0002098_abnormal_vibrissa_morphology1.28564351
65MP0001216_abnormal_epidermal_layer1.28101627
66MP0000377_abnormal_hair_follicle1.25038548
67MP0010030_abnormal_orbit_morphology1.24847780
68MP0003315_abnormal_perineum_morphology1.24177334
69MP0000627_abnormal_mammary_gland1.23948157
70MP0000537_abnormal_urethra_morphology1.23011385
71MP0009053_abnormal_anal_canal1.21276177
72MP0005023_abnormal_wound_healing1.20371963
73MP0003806_abnormal_nucleotide_metabolis1.20170108
74MP0002697_abnormal_eye_size1.19666770
75MP0003937_abnormal_limbs/digits/tail_de1.18078102
76MP0005389_reproductive_system_phenotype1.16762469
77MP0003121_genomic_imprinting1.15843269
78MP0003890_abnormal_embryonic-extraembry1.15836634
79MP0001293_anophthalmia1.11451573
80MP0000762_abnormal_tongue_morphology1.11385275
81MP0003942_abnormal_urinary_system1.10671636
82MP0001340_abnormal_eyelid_morphology1.10239640
83MP0001919_abnormal_reproductive_system1.10002816
84MP0002233_abnormal_nose_morphology1.07304873
85MP0000750_abnormal_muscle_regeneration1.04308425
86MP0009780_abnormal_chondrocyte_physiolo1.03405507
87MP0001485_abnormal_pinna_reflex1.02914621
88MP0002751_abnormal_autonomic_nervous1.02076959
89MP0004133_heterotaxia1.02008173
90MP0008877_abnormal_DNA_methylation1.00571373
91MP0000428_abnormal_craniofacial_morphol1.00133769
92MP0002111_abnormal_tail_morphology1.00052632
93MP0004272_abnormal_basement_membrane0.99814082
94MP0003221_abnormal_cardiomyocyte_apopto0.98406458
95MP0000367_abnormal_coat/_hair0.95514979
96MP0000490_abnormal_crypts_of0.95319681
97MP0004381_abnormal_hair_follicle0.94521322
98MP0002060_abnormal_skin_morphology0.93956185
99MP0003878_abnormal_ear_physiology0.93599238
100MP0005377_hearing/vestibular/ear_phenot0.93599238
101MP0003936_abnormal_reproductive_system0.91921344
102MP0003787_abnormal_imprinting0.91867300
103MP0002210_abnormal_sex_determination0.91598109
104MP0001145_abnormal_male_reproductive0.90679270
105MP0003755_abnormal_palate_morphology0.90663746
106MP0005275_abnormal_skin_tensile0.90410138
107MP0000467_abnormal_esophagus_morphology0.90116418
108MP0000516_abnormal_urinary_system0.89820216
109MP0005367_renal/urinary_system_phenotyp0.89820216
110MP0003935_abnormal_craniofacial_develop0.89807725
111MP0000534_abnormal_ureter_morphology0.89518174
112MP0005395_other_phenotype0.88964258
113MP0004185_abnormal_adipocyte_glucose0.87934268
114MP0002177_abnormal_outer_ear0.87729923
115MP0000313_abnormal_cell_death0.87191995
116MP0008260_abnormal_autophagy0.87021918
117MP0002638_abnormal_pupillary_reflex0.86176401
118MP0002019_abnormal_tumor_incidence0.85041555
119MP0000566_synostosis0.84251912
120MP0002249_abnormal_larynx_morphology0.80231783
121MP0009840_abnormal_foam_cell0.78326635
122MP0003950_abnormal_plasma_membrane0.78103850
123MP0009703_decreased_birth_body0.77887452
124MP0001881_abnormal_mammary_gland0.77640835
125MP0000432_abnormal_head_morphology0.75801962
126MP0001286_abnormal_eye_development0.75445900
127MP0005197_abnormal_uvea_morphology0.74224043
128MP0000653_abnormal_sex_gland0.74211981
129MP0004084_abnormal_cardiac_muscle0.74139314
130MP0002092_abnormal_eye_morphology0.73520232
131MP0001727_abnormal_embryo_implantation0.73029805
132MP0002396_abnormal_hematopoietic_system0.73019458
133MP0001177_atelectasis0.72675996
134MP0002116_abnormal_craniofacial_bone0.72487625
135MP0005621_abnormal_cell_physiology0.71678955
136MP0009250_abnormal_appendicular_skeleto0.71337713
137MP0003938_abnormal_ear_development0.70650344
138MP0005384_cellular_phenotype0.70255269
139MP0010771_integument_phenotype0.69318749
140MP0009672_abnormal_birth_weight0.69221120
141MP0001929_abnormal_gametogenesis0.68315234

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)4.47417880
2Birth length less than 3rd percentile (HP:0003561)4.29045109
3Pili torti (HP:0003777)4.23865352
4Selective tooth agenesis (HP:0001592)4.13580883
5Ependymoma (HP:0002888)4.07619342
6Abnormality of the labia minora (HP:0012880)3.68375863
7Absent radius (HP:0003974)3.46696358
8Carpal bone hypoplasia (HP:0001498)3.45932468
9Absent forearm bone (HP:0003953)3.26688765
10Aplasia involving forearm bones (HP:0009822)3.26688765
11Cerebral hypomyelination (HP:0006808)3.26216355
12Rough bone trabeculation (HP:0100670)3.22529699
13Impulsivity (HP:0100710)3.17080890
14Oral leukoplakia (HP:0002745)3.16817950
15Abnormality of the frontal sinuses (HP:0002687)3.14634901
16Curly hair (HP:0002212)3.11913380
17Patellar aplasia (HP:0006443)3.10493295
18Aplasia/Hypoplasia of the patella (HP:0006498)3.01423829
19Breast carcinoma (HP:0003002)2.88227162
20Sparse eyelashes (HP:0000653)2.85015461
21Esophageal atresia (HP:0002032)2.82592068
22Aplasia/Hypoplasia of the fovea (HP:0008060)2.80286912
23Hypoplasia of the fovea (HP:0007750)2.80286912
24Aplasia/hypoplasia of the humerus (HP:0006507)2.80136985
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.77510438
26Abnormality of the nasal septum (HP:0000419)2.74713468
27Ectopic kidney (HP:0000086)2.71519450
28Erythroderma (HP:0001019)2.71345174
29Fragile nails (HP:0001808)2.71170333
30Premature ovarian failure (HP:0008209)2.70970377
31Septate vagina (HP:0001153)2.70493579
32Congenital ichthyosiform erythroderma (HP:0007431)2.69256369
33Right ventricular cardiomyopathy (HP:0011663)2.68538206
34Astrocytoma (HP:0009592)2.67696744
35Abnormality of the astrocytes (HP:0100707)2.67696744
36Amelogenesis imperfecta (HP:0000705)2.64517751
37Trismus (HP:0000211)2.62809229
38Microglossia (HP:0000171)2.62672281
39Glioma (HP:0009733)2.60849260
40Neoplasm of the oral cavity (HP:0100649)2.58600761
41Duplicated collecting system (HP:0000081)2.56938205
42Abnormality of the renal collecting system (HP:0004742)2.51628432
43Follicular hyperkeratosis (HP:0007502)2.51354397
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.50429859
45Abnormality of the dental root (HP:0006486)2.49743268
46Taurodontia (HP:0000679)2.49743268
47Abnormality of permanent molar morphology (HP:0011071)2.49743268
48Medulloblastoma (HP:0002885)2.49513398
49Abnormality of the salivary glands (HP:0010286)2.44365858
50Shawl scrotum (HP:0000049)2.43955659
51Sparse lateral eyebrow (HP:0005338)2.43752042
52Short humerus (HP:0005792)2.42799480
53Colon cancer (HP:0003003)2.42765565
54Aplasia cutis congenita (HP:0001057)2.42615013
55Milia (HP:0001056)2.40811224
56Nail dystrophy (HP:0008404)2.40422789
57Breast aplasia (HP:0100783)2.40233605
58Abnormality of the axillary hair (HP:0100134)2.39881546
59Abnormality of secondary sexual hair (HP:0009888)2.39881546
60Biliary tract neoplasm (HP:0100574)2.38884921
61Short hallux (HP:0010109)2.38633920
62Hypotrichosis (HP:0001006)2.38336884
63Abnormality of dental color (HP:0011073)2.37747488
64Pendular nystagmus (HP:0012043)2.36762101
65Ureteral duplication (HP:0000073)2.36343216
66Abnormal trabecular bone morphology (HP:0100671)2.34055923
67Stenosis of the external auditory canal (HP:0000402)2.33481817
68Abnormality of nail color (HP:0100643)2.32277885
69Abnormality of chromosome stability (HP:0003220)2.31378615
70Woolly hair (HP:0002224)2.29582780
71Aplasia/Hypoplasia of the breasts (HP:0010311)2.29557146
72Concave nail (HP:0001598)2.29394512
73Abnormality of molar morphology (HP:0011070)2.27850820
74Abnormality of molar (HP:0011077)2.27850820
75Abnormality of the dental pulp (HP:0006479)2.27762481
76Supernumerary spleens (HP:0009799)2.23918031
77Facial hemangioma (HP:0000329)2.21697706
78Abnormality of the parathyroid morphology (HP:0011766)2.21555081
79Abnormality of the fovea (HP:0000493)2.21172034
80Abnormality of the anterior horn cell (HP:0006802)2.21163107
81Degeneration of anterior horn cells (HP:0002398)2.21163107
82Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.19148075
83Short 1st metacarpal (HP:0010034)2.19148075
84Multiple enchondromatosis (HP:0005701)2.18229073
85Absent thumb (HP:0009777)2.18155987
86Rhabdomyosarcoma (HP:0002859)2.17044126
87Oligodactyly (HP:0012165)2.16111648
88Long nose (HP:0003189)2.15747604
89Abnormal hair laboratory examination (HP:0003328)2.15522587
90Adrenal hypoplasia (HP:0000835)2.15401591
91Meckel diverticulum (HP:0002245)2.14693784
92Hamartoma of the eye (HP:0010568)2.14414581
93Conjunctival hamartoma (HP:0100780)2.14243216
94Chromsome breakage (HP:0040012)2.13940910
95Reticulocytopenia (HP:0001896)2.13903592
96Neoplasm of the pancreas (HP:0002894)2.13891768
97Secondary amenorrhea (HP:0000869)2.13805485
98Blepharitis (HP:0000498)2.12630051
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10752427
100Rib fusion (HP:0000902)2.10511617
101Fused cervical vertebrae (HP:0002949)2.09927282
102Aplasia/Hypoplasia of the hallux (HP:0008362)2.07673217
103Abnormality of the ileum (HP:0001549)2.05834208
104Abnormality of the umbilical cord (HP:0010881)2.05320334
105Hypoplastic labia majora (HP:0000059)2.04140746
106Abnormality of the preputium (HP:0100587)2.02787841
107Renal agenesis (HP:0000104)2.02280072
108Deep philtrum (HP:0002002)2.01732486
109Natal tooth (HP:0000695)2.00871452
110Atresia of the external auditory canal (HP:0000413)1.99358310
111Spinal muscular atrophy (HP:0007269)1.98260146
112Short middle phalanx of the 5th finger (HP:0004220)1.98196105
113Aplasia involving bones of the extremities (HP:0009825)1.97720103
114Aplasia involving bones of the upper limbs (HP:0009823)1.97720103
115Aplasia of the phalanges of the hand (HP:0009802)1.97720103
116Wide intermamillary distance (HP:0006610)1.97580766
117Depressed nasal tip (HP:0000437)1.96682250
118Abnormality of the carotid arteries (HP:0005344)1.96244576
119Horseshoe kidney (HP:0000085)1.94966989
120CNS hypomyelination (HP:0003429)1.94713552
121Deviation of the thumb (HP:0009603)1.94347434
122Triphalangeal thumb (HP:0001199)1.94087202
123Oligodactyly (hands) (HP:0001180)1.92505300
124Morphological abnormality of the middle ear (HP:0008609)1.92312489
125Alopecia of scalp (HP:0002293)1.92303657
126Aqueductal stenosis (HP:0002410)1.90669666
127Hyperglycinemia (HP:0002154)1.90190383
128Proximal placement of thumb (HP:0009623)1.89446974
129Abnormal number of incisors (HP:0011064)1.89087741
130Premature graying of hair (HP:0002216)1.88989208
131Abnormality of the proximal phalanges of the hand (HP:0009834)1.88201939
132Abnormality of the distal phalanges of the toes (HP:0010182)1.87512265
133Neoplasm of striated muscle (HP:0009728)1.86143246
134Absent eyelashes (HP:0000561)1.85985611
135Tracheoesophageal fistula (HP:0002575)1.85547789
136Ankle contracture (HP:0006466)1.85351326
137Agnosia (HP:0010524)1.84872213
138Lip pit (HP:0100267)1.84017652
139Abnormal blistering of the skin (HP:0008066)1.82521719
140Median cleft lip (HP:0000161)1.82505931
141Abnormality of the 1st metacarpal (HP:0010009)1.81170848
142Small intestinal stenosis (HP:0012848)1.80906447
143Duodenal stenosis (HP:0100867)1.80906447
144Absent hand (HP:0004050)1.80624440
145Areflexia of lower limbs (HP:0002522)1.80433076
146Advanced eruption of teeth (HP:0006288)1.79852233
147Anal stenosis (HP:0002025)1.79456641
148Squamous cell carcinoma (HP:0002860)1.79338888
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78519425
150Difficulty climbing stairs (HP:0003551)1.77881410
151Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77808137
152Hemivertebrae (HP:0002937)1.77611558
153Abnormality of the labia majora (HP:0012881)1.77237672
154Plantar hyperkeratosis (HP:0007556)1.76661802
155Missing ribs (HP:0000921)1.76489565
156Death in infancy (HP:0001522)1.75850049
157Short thumb (HP:0009778)1.75794530
158Abnormality of the fetal cardiovascular system (HP:0010948)1.75049621
159Abnormal umbilical cord blood vessels (HP:0011403)1.75049621
160Single umbilical artery (HP:0001195)1.75049621
161Progressive muscle weakness (HP:0003323)1.74396249
162Choanal atresia (HP:0000453)1.73042416
163Severe Myopia (HP:0011003)1.69632417
164Abnormality of the aortic arch (HP:0012303)1.64243625
165High anterior hairline (HP:0009890)1.62733871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.03006026
2BUB14.62413745
3PLK44.48916854
4WEE14.48080194
5TTK2.86654575
6TSSK62.86045181
7STK242.84980156
8NEK12.54069361
9PNCK2.43502280
10NEK22.42767834
11PBK2.37150431
12STK392.36722226
13RPS6KB22.34570096
14VRK22.20451331
15AKT32.09184108
16CDC72.04085575
17NUAK11.96241371
18GRK11.94267644
19CDK121.92858677
20LATS21.91786119
21PLK11.90697128
22TAF11.89464667
23EIF2AK11.78364829
24SRPK11.74841592
25PLK31.65509307
26NME21.61668707
27ACVR1B1.58999934
28TRIM281.54965133
29STK101.54857872
30BRSK21.54551930
31STK38L1.51777876
32OXSR11.50805590
33MST41.43737119
34CDK71.42796329
35LATS11.41955109
36MUSK1.39657297
37MAP3K81.38061138
38DYRK31.34628204
39MAP3K121.34316786
40CHEK21.33800892
41ALK1.33097931
42PIK3CA1.31854106
43AURKB1.29730549
44AURKA1.29338955
45PRKCI1.26143966
46MAPKAPK31.23907644
47PAK41.10393151
48EEF2K1.09504602
49MKNK21.05681891
50MKNK11.04908697
51STK31.04219593
52EIF2AK31.02224210
53SIK11.02048337
54CHEK11.01018375
55FRK0.99996937
56SMG10.98747914
57NEK60.98473160
58CASK0.98160242
59PDK40.97564460
60PDK30.97564460
61SIK30.95359432
62CDK40.92239452
63ATR0.89519382
64FER0.89020300
65ZAK0.86723231
66PDK20.86523796
67MAP3K30.84846297
68PKN20.81704320
69MTOR0.80257239
70MAP2K10.78564698
71BRAF0.77364024
72CDK20.76825520
73MATK0.76381119
74TESK20.75231351
75ILK0.74865349
76BRSK10.73796278
77FGFR20.72433072
78LRRK20.72099580
79STK160.69642713
80IRAK20.69536492
81PAK10.69234306
82CDK30.69130000
83CSNK1E0.67154741
84CDK60.66185647
85RPS6KB10.65647117
86RPS6KA40.64865084
87PASK0.64744651
88HIPK20.64198036
89PLK20.62957666
90ATM0.61144554
91MET0.59352750
92CHUK0.58236094
93MAP2K20.56204107
94PIM10.55933997
95MAP3K90.54412981
96PRKCE0.53028287
97NME10.52532856
98INSRR0.52174093
99CDK10.51938029
100TRIB30.50772485
101MAPK130.50609345
102CSNK2A20.49805653
103AKT20.49654740
104PIM20.47965091
105CDK90.47772180
106MELK0.45384475
107BMX0.45074568
108DMPK0.44344327
109SCYL20.43990919
110CSNK2A10.42408120
111WNK40.42185337
112PTK2B0.42089389
113TNIK0.41975785
114BCR0.41934802
115TGFBR10.40775825
116VRK10.40367394
117DDR20.39439258
118ADRBK20.39064478
119DYRK20.38224534
120TYRO30.37467095
121ICK0.37042296
122STK380.37015543
123TAOK10.34180509
124FGFR10.34049346
125BRD40.33963353
126MST1R0.33930706
127PTK20.33371953
128MAP3K110.31841502
129STK40.31385732
130MAPKAPK50.31125852
131CSNK1A10.31044365
132PAK30.30554142
133CSNK1D0.29605250
134TESK10.29122531
135ARAF0.27822822
136PAK20.26132109
137RPS6KA10.25335388
138TAOK20.23827583
139EIF2AK20.23670268
140LIMK10.21568271
141RAF10.19915574
142MAPK140.19414233
143PRKDC0.19321367

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.41871306
2RNA transport_Homo sapiens_hsa030133.67919247
3DNA replication_Homo sapiens_hsa030303.53519561
4RNA polymerase_Homo sapiens_hsa030203.47641471
5Mismatch repair_Homo sapiens_hsa034303.44008951
6Vitamin B6 metabolism_Homo sapiens_hsa007503.14462807
7Spliceosome_Homo sapiens_hsa030403.02975401
8Proteasome_Homo sapiens_hsa030502.91764339
9Cell cycle_Homo sapiens_hsa041102.76295230
10Ribosome_Homo sapiens_hsa030102.60878872
11Nucleotide excision repair_Homo sapiens_hsa034202.46882821
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46722191
13Base excision repair_Homo sapiens_hsa034102.42520114
14Homologous recombination_Homo sapiens_hsa034402.35181805
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.02290448
16p53 signaling pathway_Homo sapiens_hsa041151.99377399
17One carbon pool by folate_Homo sapiens_hsa006701.97735678
18Pyrimidine metabolism_Homo sapiens_hsa002401.96777142
19Basal transcription factors_Homo sapiens_hsa030221.90196070
20Fanconi anemia pathway_Homo sapiens_hsa034601.82006691
21mRNA surveillance pathway_Homo sapiens_hsa030151.72860002
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57252945
23RNA degradation_Homo sapiens_hsa030181.56723633
24Folate biosynthesis_Homo sapiens_hsa007901.48429282
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42507815
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41345420
27Steroid biosynthesis_Homo sapiens_hsa001001.40226276
28Hippo signaling pathway_Homo sapiens_hsa043901.36827887
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35676296
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33952686
31Protein export_Homo sapiens_hsa030601.32109498
32Oocyte meiosis_Homo sapiens_hsa041141.30394270
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30186969
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25717790
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.23719100
36Caffeine metabolism_Homo sapiens_hsa002321.22584229
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20346407
38Epstein-Barr virus infection_Homo sapiens_hsa051691.17992619
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17342285
40Collecting duct acid secretion_Homo sapiens_hsa049661.17307960
41Fatty acid elongation_Homo sapiens_hsa000621.14365342
42Non-homologous end-joining_Homo sapiens_hsa034501.12483611
43Basal cell carcinoma_Homo sapiens_hsa052171.09909123
44Pentose phosphate pathway_Homo sapiens_hsa000301.05114416
45Regulation of autophagy_Homo sapiens_hsa041401.03196729
46Purine metabolism_Homo sapiens_hsa002301.03171684
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02106241
48Hedgehog signaling pathway_Homo sapiens_hsa043400.99514648
49Biosynthesis of amino acids_Homo sapiens_hsa012300.98794239
50Adherens junction_Homo sapiens_hsa045200.97548856
51N-Glycan biosynthesis_Homo sapiens_hsa005100.96130001
52MicroRNAs in cancer_Homo sapiens_hsa052060.95830445
53Tight junction_Homo sapiens_hsa045300.94639539
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92681642
55Sphingolipid metabolism_Homo sapiens_hsa006000.89699070
56Oxidative phosphorylation_Homo sapiens_hsa001900.88371239
57Fructose and mannose metabolism_Homo sapiens_hsa000510.86205007
58mTOR signaling pathway_Homo sapiens_hsa041500.85821594
59Phototransduction_Homo sapiens_hsa047440.85378944
60Thyroid cancer_Homo sapiens_hsa052160.84259190
61Lysine degradation_Homo sapiens_hsa003100.84254212
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.83952244
63Chemical carcinogenesis_Homo sapiens_hsa052040.83604014
64Small cell lung cancer_Homo sapiens_hsa052220.79150377
65Ovarian steroidogenesis_Homo sapiens_hsa049130.78486867
66Viral carcinogenesis_Homo sapiens_hsa052030.78180981
67Linoleic acid metabolism_Homo sapiens_hsa005910.77299874
68Antigen processing and presentation_Homo sapiens_hsa046120.73101460
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.72011451
70TGF-beta signaling pathway_Homo sapiens_hsa043500.71889981
71Bladder cancer_Homo sapiens_hsa052190.71441438
72Histidine metabolism_Homo sapiens_hsa003400.70102554
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68724881
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68623432
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68139850
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.67806159
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.67259901
78HTLV-I infection_Homo sapiens_hsa051660.65984998
79Huntingtons disease_Homo sapiens_hsa050160.64760218
80Notch signaling pathway_Homo sapiens_hsa043300.63791946
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62240003
82Melanogenesis_Homo sapiens_hsa049160.60735236
83Vibrio cholerae infection_Homo sapiens_hsa051100.56426738
84Axon guidance_Homo sapiens_hsa043600.56094001
85Selenocompound metabolism_Homo sapiens_hsa004500.55960382
86Galactose metabolism_Homo sapiens_hsa000520.54155242
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52745761
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51701717
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.50922153
90Prostate cancer_Homo sapiens_hsa052150.47651675
91Proteoglycans in cancer_Homo sapiens_hsa052050.45203367
92Renal cell carcinoma_Homo sapiens_hsa052110.44541147
93Pathways in cancer_Homo sapiens_hsa052000.44145797
94HIF-1 signaling pathway_Homo sapiens_hsa040660.44082383
95Metabolic pathways_Homo sapiens_hsa011000.43497590
96Endometrial cancer_Homo sapiens_hsa052130.43483690
97Vitamin digestion and absorption_Homo sapiens_hsa049770.43435950
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43393616
99Glutathione metabolism_Homo sapiens_hsa004800.42958753
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42883098
101Colorectal cancer_Homo sapiens_hsa052100.42871068
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42768142
103Herpes simplex infection_Homo sapiens_hsa051680.42521889
104Retinol metabolism_Homo sapiens_hsa008300.42193029
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41269605
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40906989
107Carbon metabolism_Homo sapiens_hsa012000.40877675
108Tyrosine metabolism_Homo sapiens_hsa003500.40707145
109Wnt signaling pathway_Homo sapiens_hsa043100.40533002
110Arachidonic acid metabolism_Homo sapiens_hsa005900.39759885
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39682986
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38180452
113ECM-receptor interaction_Homo sapiens_hsa045120.36581089
114Mineral absorption_Homo sapiens_hsa049780.36451108
115Sulfur relay system_Homo sapiens_hsa041220.35684051
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34848426
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34420935
118Hepatitis C_Homo sapiens_hsa051600.33541889
119Acute myeloid leukemia_Homo sapiens_hsa052210.33507533
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32793350
121FoxO signaling pathway_Homo sapiens_hsa040680.31773224
122Arginine and proline metabolism_Homo sapiens_hsa003300.31279157
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27958501
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26558003
125Fatty acid biosynthesis_Homo sapiens_hsa000610.25860804
126Circadian rhythm_Homo sapiens_hsa047100.25069555
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24878091
128AMPK signaling pathway_Homo sapiens_hsa041520.23086886
129Apoptosis_Homo sapiens_hsa042100.21148001
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19618767
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19181852
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19004775
133Melanoma_Homo sapiens_hsa052180.18872776
134Legionellosis_Homo sapiens_hsa051340.17954784
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17009698
136Dorso-ventral axis formation_Homo sapiens_hsa043200.16964660

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