TFAP2E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.67498881
2regulation of female gonad development (GO:2000194)7.17048055
3regulation of meiosis (GO:0040020)6.17344113
4protein K6-linked ubiquitination (GO:0085020)6.00852740
5regulation of exit from mitosis (GO:0007096)5.99614557
6female gamete generation (GO:0007292)5.93862859
7mitotic metaphase plate congression (GO:0007080)5.93711945
8histone H2A monoubiquitination (GO:0035518)5.90773031
9mitotic chromosome condensation (GO:0007076)5.81368281
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.74763759
11histone H2A ubiquitination (GO:0033522)5.45329106
12regulation of sister chromatid cohesion (GO:0007063)5.43777318
13oocyte maturation (GO:0001556)5.39870016
14regulation of meiotic cell cycle (GO:0051445)5.25359466
15regulation of histone H3-K27 methylation (GO:0061085)5.21565703
16activated T cell proliferation (GO:0050798)5.01790043
17negative regulation of meiosis (GO:0045835)5.00491861
18sphingosine metabolic process (GO:0006670)4.98364171
19DNA methylation involved in gamete generation (GO:0043046)4.97972305
20metaphase plate congression (GO:0051310)4.94982959
21base-excision repair, AP site formation (GO:0006285)4.91336059
22male meiosis (GO:0007140)4.90929581
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.83296004
24negative regulation of smooth muscle cell differentiation (GO:0051151)4.73760704
25establishment of chromosome localization (GO:0051303)4.62858035
26regulation of meiosis I (GO:0060631)4.60679656
27notochord development (GO:0030903)4.58955712
28meiotic cell cycle (GO:0051321)4.57683382
29negative regulation of meiotic cell cycle (GO:0051447)4.57589618
30DNA damage induced protein phosphorylation (GO:0006975)4.57528568
31attachment of spindle microtubules to kinetochore (GO:0008608)4.51561971
32antigen processing and presentation of endogenous antigen (GO:0019883)4.44534428
33diol metabolic process (GO:0034311)4.41836551
34female gonad development (GO:0008585)4.41625157
35regulation of retinoic acid receptor signaling pathway (GO:0048385)4.41158013
36positive regulation of gamma-delta T cell activation (GO:0046645)4.40510824
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.35223042
38sphingoid metabolic process (GO:0046519)4.33777783
39regulation of germinal center formation (GO:0002634)4.31248714
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.26314013
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22622120
42positive regulation of meiotic cell cycle (GO:0051446)4.16953434
43gene silencing by RNA (GO:0031047)4.10777330
44regulation of acrosome reaction (GO:0060046)4.09895488
45ribosomal small subunit assembly (GO:0000028)4.09489014
46meiotic chromosome segregation (GO:0045132)4.08329682
47negative regulation of keratinocyte proliferation (GO:0010839)4.02674958
48citrulline biosynthetic process (GO:0019240)4.01374934
49DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.99845991
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98313334
51microtubule severing (GO:0051013)3.97682202
52DNA damage response, signal transduction resulting in transcription (GO:0042772)3.97496677
53positive thymic T cell selection (GO:0045059)3.95817811
54regulation of keratinocyte proliferation (GO:0010837)3.95776838
55positive T cell selection (GO:0043368)3.95339687
56positive regulation of B cell differentiation (GO:0045579)3.87421000
57negative regulation of DNA-templated transcription, elongation (GO:0032785)3.76266941
58negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.76266941
59mitotic sister chromatid segregation (GO:0000070)3.75920075
60pyrimidine nucleotide catabolic process (GO:0006244)3.75569523
61DNA methylation (GO:0006306)3.68545906
62DNA alkylation (GO:0006305)3.68545906
63negative regulation of erythrocyte differentiation (GO:0045647)3.64091107
64type B pancreatic cell development (GO:0003323)3.63806090
65mitotic sister chromatid cohesion (GO:0007064)3.61575615
66negative regulation of B cell apoptotic process (GO:0002903)3.58227525
67monoubiquitinated protein deubiquitination (GO:0035520)3.57415419
68cell wall macromolecule metabolic process (GO:0044036)3.55939696
69maturation of 5.8S rRNA (GO:0000460)3.54779177
70protein localization to chromosome, centromeric region (GO:0071459)3.53489283
71myoblast migration (GO:0051451)3.52588327
72positive regulation of megakaryocyte differentiation (GO:0045654)3.52466534
73negative regulation of reproductive process (GO:2000242)3.52366627
74negative regulation of cell killing (GO:0031342)3.51352631
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51352631
76negative regulation of hormone metabolic process (GO:0032351)3.50238693
77negative regulation of hormone biosynthetic process (GO:0032353)3.50238693
78positive regulation of meiosis (GO:0045836)3.49486042
79positive regulation of Cdc42 GTPase activity (GO:0043089)3.47374160
80purine deoxyribonucleotide catabolic process (GO:0009155)3.43218710
81oogenesis (GO:0048477)3.41623153
82regulation of keratinocyte differentiation (GO:0045616)3.40030418
83chaperone-mediated protein transport (GO:0072321)3.35806012
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.34756448
85sister chromatid cohesion (GO:0007062)3.34728378
86protein localization to kinetochore (GO:0034501)3.31424167
87regulation of transforming growth factor beta2 production (GO:0032909)3.30780645
88negative regulation of T-helper cell differentiation (GO:0045623)3.30449425
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.30449425
90oocyte development (GO:0048599)3.29604365
91regulation of spindle organization (GO:0090224)3.28676420
92ovulation cycle (GO:0042698)3.26770187
93protein localization to chromosome (GO:0034502)3.25825626
94ubiquinone biosynthetic process (GO:0006744)3.25633045
95multicellular organism reproduction (GO:0032504)3.25626923
96chromosome segregation (GO:0007059)3.25116857
97snRNA transcription (GO:0009301)3.23044921
98T cell selection (GO:0045058)3.19911039
99seminiferous tubule development (GO:0072520)3.19020726
100B cell receptor signaling pathway (GO:0050853)3.18910943
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.18792147
102definitive hemopoiesis (GO:0060216)3.18268969
103mucosal-associated lymphoid tissue development (GO:0048537)3.17849294
104Peyers patch development (GO:0048541)3.17849294
105negative T cell selection (GO:0043383)3.17102830
106regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.13871267
107regulation of transcription from RNA polymerase I promoter (GO:0006356)3.13046169
108positive regulation of chromosome segregation (GO:0051984)3.12849343
109regulation of chromosome segregation (GO:0051983)3.11715642
110intestinal epithelial cell development (GO:0060576)3.11138847
111negative regulation of cell aging (GO:0090344)3.09134583
112positive regulation of chemokine secretion (GO:0090197)3.08132747
113synaptonemal complex assembly (GO:0007130)3.06794931
114positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05394386
115negative thymic T cell selection (GO:0045060)3.05214224
116regulation of gamma-delta T cell differentiation (GO:0045586)3.04827568
117glycerophospholipid catabolic process (GO:0046475)3.04548601
118mast cell activation involved in immune response (GO:0002279)3.04294995
119mast cell degranulation (GO:0043303)3.04294995
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.03588018
121regulation of DNA methylation (GO:0044030)3.02618252
122microtubule nucleation (GO:0007020)3.00512962
123regulation of establishment of cell polarity (GO:2000114)3.00226431
124Arp2/3 complex-mediated actin nucleation (GO:0034314)2.99153581
125resolution of meiotic recombination intermediates (GO:0000712)2.98700166
126meiotic nuclear division (GO:0007126)2.98357690
127response to interleukin-15 (GO:0070672)2.98047717
128cellular extravasation (GO:0045123)2.97262827
129meiotic cell cycle process (GO:1903046)2.97251332
130leukocyte cell-cell adhesion (GO:0007159)2.96595099
131spindle checkpoint (GO:0031577)2.95526955
132histone monoubiquitination (GO:0010390)2.93659352
133regulation of hypersensitivity (GO:0002883)2.92812042
134sister chromatid segregation (GO:0000819)2.92229087
135regulation of Cdc42 GTPase activity (GO:0043088)2.91572541
136neutrophil activation (GO:0042119)2.90758712
137kinetochore assembly (GO:0051382)2.88798248
138synaptic vesicle maturation (GO:0016188)2.88779093
139thymic T cell selection (GO:0045061)2.87919780
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.87546606
141positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.87546606
142positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.87546606
143purine deoxyribonucleotide metabolic process (GO:0009151)2.86823543
144germinal center formation (GO:0002467)2.86457395
145regulation of B cell differentiation (GO:0045577)2.85887443
146negative regulation of cell division (GO:0051782)2.84658158
147negative regulation of leukocyte mediated immunity (GO:0002704)2.83275120
148regulation of chemokine secretion (GO:0090196)2.82966865
149regulation of regulatory T cell differentiation (GO:0045589)2.82750789
150regulation of gamma-delta T cell activation (GO:0046643)2.81756981
151phosphatidylglycerol biosynthetic process (GO:0006655)2.80669961
152UV protection (GO:0009650)2.80457855
153response to misfolded protein (GO:0051788)2.78792070
154synaptic vesicle exocytosis (GO:0016079)2.77166614
155regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75235342
156ncRNA 3-end processing (GO:0043628)2.73820088
157DNA integration (GO:0015074)2.73286163
158ubiquinone metabolic process (GO:0006743)2.71475743
159negative regulation of lymphocyte mediated immunity (GO:0002707)2.69811144
160immunoglobulin mediated immune response (GO:0016064)2.68316345
161leukocyte aggregation (GO:0070486)2.65949728
162positive regulation of granulocyte differentiation (GO:0030854)2.65836761
163regulation of B cell receptor signaling pathway (GO:0050855)2.65503589
164programmed necrotic cell death (GO:0097300)2.64810553
165neutrophil activation involved in immune response (GO:0002283)2.64430929
166granulocyte activation (GO:0036230)2.63744915
167regulation of glutamate receptor signaling pathway (GO:1900449)2.63218511
168necrotic cell death (GO:0070265)2.62853515
169regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62172801
170regulation of natural killer cell mediated immunity (GO:0002715)2.62172801
171regulation of activation of Janus kinase activity (GO:0010533)2.62032176
172mast cell activation (GO:0045576)2.61013851
173cellular response to exogenous dsRNA (GO:0071360)2.60999425
174regulation of interleukin-2 biosynthetic process (GO:0045076)2.60368880
175purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.59305259
176positive regulation of T cell differentiation in thymus (GO:0033089)2.58046089
177positive regulation of interleukin-4 production (GO:0032753)2.57000629
178heterotypic cell-cell adhesion (GO:0034113)2.55413981
179positive regulation of interleukin-17 production (GO:0032740)2.54147225
180cellular anion homeostasis (GO:0030002)2.52299181
181positive regulation of antigen processing and presentation (GO:0002579)2.50956884
182stress granule assembly (GO:0034063)2.50591440
183negative regulation of lymphocyte apoptotic process (GO:0070229)2.50405197
184regulation of interleukin-4 production (GO:0032673)2.50167180
185actin nucleation (GO:0045010)2.49528699
186positive regulation of calcium-mediated signaling (GO:0050850)2.49385318
187T cell migration (GO:0072678)2.48987581
188leukocyte degranulation (GO:0043299)2.47864795
189regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47482724
190quinone biosynthetic process (GO:1901663)2.46356405
191regulation of synaptic vesicle exocytosis (GO:2000300)2.45234114
192negative regulation of T cell apoptotic process (GO:0070233)2.44186992
193regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.42781622
194regulation of T-helper 2 cell differentiation (GO:0045628)2.42613719
195cellular response to interleukin-15 (GO:0071350)2.42337345
196antigen receptor-mediated signaling pathway (GO:0050851)2.42272808
197regulation of synaptic vesicle transport (GO:1902803)2.41893827
198regulation of cytokine production involved in inflammatory response (GO:1900015)2.41195539
199positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.40214104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.88540722
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.04640062
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.82274716
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.56122691
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.45801894
6KAP1_22055183_ChIP-Seq_ESCs_Mouse3.42630705
7VDR_21846776_ChIP-Seq_THP-1_Human3.38651225
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.31372427
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.18026592
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.15913629
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.11280238
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.88647303
13AR_21909140_ChIP-Seq_LNCAP_Human2.73933095
14SCL_19346495_ChIP-Seq_HPC-7_Human2.67088392
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62150839
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.61984082
17E2F7_22180533_ChIP-Seq_HELA_Human2.61633645
18VDR_24763502_ChIP-Seq_THP-1_Human2.44602510
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.39479328
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31940587
21ELF1_20517297_ChIP-Seq_JURKAT_Human2.30660377
22MAF_26560356_Chip-Seq_TH2_Human2.28418087
23P68_20966046_ChIP-Seq_HELA_Human2.23771206
24* UTX_26944678_Chip-Seq_JUKART_Human2.23426648
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22809836
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20716059
27MYC_22102868_ChIP-Seq_BL_Human2.19847246
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17372563
29MAF_26560356_Chip-Seq_TH1_Human2.13835947
30BCL6_27268052_Chip-Seq_Bcells_Human2.13709000
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11573365
32LXR_22292898_ChIP-Seq_THP-1_Human2.10520251
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03535536
34CIITA_25753668_ChIP-Seq_RAJI_Human2.02778238
35BCOR_27268052_Chip-Seq_Bcells_Human2.01495499
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00622939
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00009252
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.98305677
39RNF2_27304074_Chip-Seq_NSC_Mouse1.97004704
40MYC_18940864_ChIP-ChIP_HL60_Human1.92821248
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.90236432
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90098037
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88685302
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87906067
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.87624356
46* KDM2B_26808549_Chip-Seq_DND41_Human1.85294883
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.81909689
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81586615
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75160686
50MYB_26560356_Chip-Seq_TH2_Human1.73576544
51PHF8_20622854_ChIP-Seq_HELA_Human1.72119496
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.71650359
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.68524925
54LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68447674
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64723012
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.64489267
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.62859968
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.60213689
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60170641
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.56266927
61SMC4_20622854_ChIP-Seq_HELA_Human1.56159431
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.55552393
63CTCF_21964334_ChIP-Seq_BJAB-B_Human1.53681177
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.53198523
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52845904
66EZH2_22144423_ChIP-Seq_EOC_Human1.52704857
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52344628
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52235816
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.52154859
70* E2F1_20622854_ChIP-Seq_HELA_Human1.51966739
71* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51504699
72RUNX_20019798_ChIP-Seq_JUKART_Human1.51156041
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50600698
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50288255
75TCF7_22412390_ChIP-Seq_EML_Mouse1.49459767
76SPI1_23547873_ChIP-Seq_NB4_Human1.48427270
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46684355
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46575664
79GATA3_27048872_Chip-Seq_THYMUS_Human1.46140847
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45786172
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.45437556
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43840259
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42957544
84* SA1_27219007_Chip-Seq_ERYTHROID_Human1.42552949
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.41704494
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41519829
87SPI1_23127762_ChIP-Seq_K562_Human1.41211825
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40770289
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40448762
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40397058
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40288644
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39126133
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39039424
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38184558
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37611752
96P300_27268052_Chip-Seq_Bcells_Human1.35944574
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.35051368
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34834327
99CTCF_26484167_Chip-Seq_Bcells_Mouse1.33546243
100AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33025717
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31331985
102MYB_26560356_Chip-Seq_TH1_Human1.30319011
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.29710571
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29170915
105* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.28789402
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28769497
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28452961
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28443845
109* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28101766
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27736896
111* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27733453
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27688526
113OCT4_19829295_ChIP-Seq_ESCs_Human1.27258601
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27224740
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26735995
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.26466914
117SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25768279
118SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25469551
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25275145
120* NFYA_21822215_ChIP-Seq_K562_Human1.24674006
121STAT1_17558387_ChIP-Seq_HELA_Human1.24585432
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24492355
123FUS_26573619_Chip-Seq_HEK293_Human1.23878214
124ETS1_21867929_ChIP-Seq_TH2_Mouse1.23877273
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23495693
126RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23263236
127SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22326039
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21292028
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20686372
130* SA1_27219007_Chip-Seq_Bcells_Human1.20144313
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19955851
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19761661
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19554322
134IGF1R_20145208_ChIP-Seq_DFB_Human1.18606730
135* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18531209
136* KDM2B_26808549_Chip-Seq_JURKAT_Human1.18347108
137CDX2_22108803_ChIP-Seq_LS180_Human1.17430742
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17340583
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17191585
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16612363
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16259732
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16259732
143* HNFA_21074721_ChIP-Seq_CACO-2_Human1.16238795
144MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15977321
145BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15852922
146* CTCF_20526341_ChIP-Seq_ESCs_Human1.15533318
147* TBL1_22424771_ChIP-Seq_293T_Human1.15495175
148CJUN_26792858_Chip-Seq_BT549_Human1.15470667
149SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14720551
150TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14709882
151NFE2_27457419_Chip-Seq_LIVER_Mouse1.14468804
152PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14081458
153* CTCF_27219007_Chip-Seq_Bcells_Human1.12641898
154CTCF_21964334_Chip-Seq_Bcells_Human1.12529849
155YY1_22570637_ChIP-Seq_MALME-3M_Human1.12425746
156* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12416035
157SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11999767
158EWS_26573619_Chip-Seq_HEK293_Human1.11539093
159RARB_24833708_ChIP-Seq_LIVER_Mouse1.11199319
160TAF2_19829295_ChIP-Seq_ESCs_Human1.11180208
161PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10812885
162TP63_23658742_ChIP-Seq_EP156T_Human1.10585586
163PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08866006
164BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08823916
165* GATA6_21074721_ChIP-Seq_CACO-2_Human1.08118059
166FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08049084
167EZH2_27294783_Chip-Seq_NPCs_Mouse1.08010497
168REST_21632747_ChIP-Seq_MESCs_Mouse1.07740003
169* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07433563
170* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06956351
171NANOG_18555785_Chip-Seq_ESCs_Mouse1.06946130
172JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05661736
173NANOG_21062744_ChIP-ChIP_HESCs_Human1.05651808
174ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03755493
175* ETV1_20927104_ChIP-Seq_GIST48_Human1.03446085
176ERG_20517297_ChIP-Seq_VCAP_Human1.03315795
177AR_21572438_ChIP-Seq_LNCaP_Human1.01120348
178ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99676928
179TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99632500
180* RBPJ_21746931_ChIP-Seq_IB4_Human0.98674374
181* PHF8_20622853_ChIP-Seq_HELA_Human0.98297825
182* ATF3_27146783_Chip-Seq_COLON_Human0.98020606
183* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97355998
184GF1B_26923725_Chip-Seq_HPCs_Mouse0.96910609
185SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96414468
186KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96276469
187POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96144141
188KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95525773
189STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94144109
190PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94020066
191NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93823114
192CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92419621
193STAT3_23295773_ChIP-Seq_U87_Human0.91259053
194FOXH1_21741376_ChIP-Seq_EPCs_Human0.90605225
195KAP1_27257070_Chip-Seq_ESCs_Mouse0.89400461
196TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89351623
197VDR_22108803_ChIP-Seq_LS180_Human0.87570218
198PKCTHETA_26484144_Chip-Seq_BREAST_Human0.86043821
199CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86009692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.22116175
2MP0003646_muscle_fatigue4.81104617
3MP0005451_abnormal_body_composition4.77100566
4MP0003693_abnormal_embryo_hatching3.64378177
5MP0001835_abnormal_antigen_presentation3.19485010
6MP0003787_abnormal_imprinting3.12557943
7MP0008877_abnormal_DNA_methylation3.05453013
8MP0003763_abnormal_thymus_physiology2.87393912
9MP0000579_abnormal_nail_morphology2.84500936
10MP0001986_abnormal_taste_sensitivity2.82559112
11MP0003172_abnormal_lysosome_physiology2.73301737
12MP0005395_other_phenotype2.65014587
13MP0002102_abnormal_ear_morphology2.64977783
14MP0003699_abnormal_female_reproductive2.61937216
15MP0002653_abnormal_ependyma_morphology2.59783632
16MP0004957_abnormal_blastocyst_morpholog2.49535883
17MP0005671_abnormal_response_to2.46723405
18MP0006292_abnormal_olfactory_placode2.45021663
19MP0003111_abnormal_nucleus_morphology2.39137623
20MP0001800_abnormal_humoral_immune2.38094517
21MP0001119_abnormal_female_reproductive2.37869966
22MP0005000_abnormal_immune_tolerance2.36782532
23MP0003123_paternal_imprinting2.36555437
24MP0003077_abnormal_cell_cycle2.34391681
25MP0010094_abnormal_chromosome_stability2.33925872
26MP0003315_abnormal_perineum_morphology2.30804334
27MP0003724_increased_susceptibility_to2.27475334
28MP0003436_decreased_susceptibility_to2.20730490
29MP0005025_abnormal_response_to2.18221772
30MP0002796_impaired_skin_barrier2.14377169
31MP0005423_abnormal_somatic_nervous2.13227772
32MP0009379_abnormal_foot_pigmentation2.09983573
33MP0002723_abnormal_immune_serum2.08091597
34MP0003941_abnormal_skin_development2.06906369
35MP0002148_abnormal_hypersensitivity_rea2.04373420
36MP0001188_hyperpigmentation2.03614059
37MP0002420_abnormal_adaptive_immunity2.00453731
38MP0003937_abnormal_limbs/digits/tail_de1.98978037
39MP0001929_abnormal_gametogenesis1.95144797
40MP0001819_abnormal_immune_cell1.94711315
41MP0002419_abnormal_innate_immunity1.92135365
42MP0004859_abnormal_synaptic_plasticity1.90237669
43MP0009278_abnormal_bone_marrow1.89258923
44MP0000685_abnormal_immune_system1.89162324
45MP0002452_abnormal_antigen_presenting1.88802089
46MP0002398_abnormal_bone_marrow1.88654636
47MP0002249_abnormal_larynx_morphology1.87729011
48MP0000653_abnormal_sex_gland1.84700787
49MP0001346_abnormal_lacrimal_gland1.79272512
50MP0004185_abnormal_adipocyte_glucose1.79238086
51MP0002210_abnormal_sex_determination1.78532572
52MP0003121_genomic_imprinting1.74074853
53MP0005464_abnormal_platelet_physiology1.71603552
54MP0005646_abnormal_pituitary_gland1.70289308
55MP0005408_hypopigmentation1.69592997
56MP0000716_abnormal_immune_system1.68595960
57MP0006082_CNS_inflammation1.67950814
58MP0005387_immune_system_phenotype1.65323345
59MP0001790_abnormal_immune_system1.65323345
60MP0001968_abnormal_touch/_nociception1.61459133
61MP0005187_abnormal_penis_morphology1.61382753
62MP0001851_eye_inflammation1.61328222
63MP0003866_abnormal_defecation1.60511424
64MP0000465_gastrointestinal_hemorrhage1.59809897
65MP0004381_abnormal_hair_follicle1.58765865
66MP0003635_abnormal_synaptic_transmissio1.56891635
67MP0003453_abnormal_keratinocyte_physiol1.52943337
68MP0000689_abnormal_spleen_morphology1.52314553
69MP0002722_abnormal_immune_system1.50892060
70MP0000681_abnormal_thyroid_gland1.50274690
71MP0002877_abnormal_melanocyte_morpholog1.49346534
72MP0002060_abnormal_skin_morphology1.48481414
73MP0000703_abnormal_thymus_morphology1.47839223
74MP0009785_altered_susceptibility_to1.46680500
75MP0000427_abnormal_hair_cycle1.46458726
76MP0000383_abnormal_hair_follicle1.44834656
77MP0004947_skin_inflammation1.43350485
78MP0000566_synostosis1.41738188
79MP0008932_abnormal_embryonic_tissue1.39949439
80MP0005075_abnormal_melanosome_morpholog1.35320595
81MP0002933_joint_inflammation1.35218143
82MP0009333_abnormal_splenocyte_physiolog1.34932516
83MP0003136_yellow_coat_color1.34557179
84MP0002429_abnormal_blood_cell1.32326371
85MP0003690_abnormal_glial_cell1.31510902
86MP0010234_abnormal_vibrissa_follicle1.31461172
87MP0005257_abnormal_intraocular_pressure1.31198777
88MP0005174_abnormal_tail_pigmentation1.30997930
89MP0003880_abnormal_central_pattern1.28004010
90MP0002064_seizures1.27699560
91MP0008569_lethality_at_weaning1.26916956
92MP0004043_abnormal_pH_regulation1.26882257
93MP0002405_respiratory_system_inflammati1.26248973
94MP0004142_abnormal_muscle_tone1.25749040
95MP0003938_abnormal_ear_development1.25560790
96MP0001216_abnormal_epidermal_layer1.24642904
97MP0008007_abnormal_cellular_replicative1.24598303
98MP0002733_abnormal_thermal_nociception1.23812815
99MP0005397_hematopoietic_system_phenotyp1.23799643
100MP0001545_abnormal_hematopoietic_system1.23799643
101MP0010678_abnormal_skin_adnexa1.23301351
102MP0002138_abnormal_hepatobiliary_system1.22880238
103MP0005535_abnormal_body_temperature1.22316851
104MP0001502_abnormal_circadian_rhythm1.19512855
105MP0001145_abnormal_male_reproductive1.18859150
106MP0005501_abnormal_skin_physiology1.18685933
107MP0002161_abnormal_fertility/fecundity1.17884803
108MP0010155_abnormal_intestine_physiology1.17844256
109MP0002085_abnormal_embryonic_tissue1.16296849
110MP0002063_abnormal_learning/memory/cond1.15319722
111MP0005058_abnormal_lysosome_morphology1.14887541
112MP0003755_abnormal_palate_morphology1.14818947
113MP0000350_abnormal_cell_proliferation1.13649680
114MP0002822_catalepsy1.13371504
115MP0001486_abnormal_startle_reflex1.13345475
116MP0005310_abnormal_salivary_gland1.13089563
117MP0006035_abnormal_mitochondrial_morpho1.11933273
118MP0006036_abnormal_mitochondrial_physio1.11252685
119MP0001970_abnormal_pain_threshold1.09499294
120MP0002572_abnormal_emotion/affect_behav1.07560088
121MP0003950_abnormal_plasma_membrane1.06787870
122MP0001730_embryonic_growth_arrest1.06406667
123MP0006276_abnormal_autonomic_nervous1.06087198
124MP0000613_abnormal_salivary_gland1.05860723
125MP0000647_abnormal_sebaceous_gland1.05432406
126MP0001845_abnormal_inflammatory_respons1.03812981
127MP0002396_abnormal_hematopoietic_system1.03641486
128MP0000462_abnormal_digestive_system1.03573236
129MP0002163_abnormal_gland_morphology1.02805726
130MP0009745_abnormal_behavioral_response1.02539826
131MP0001529_abnormal_vocalization1.01401076
132MP0000015_abnormal_ear_pigmentation1.01299653
133MP0004264_abnormal_extraembryonic_tissu1.00432919
134MP0005645_abnormal_hypothalamus_physiol0.99871029
135MP0003879_abnormal_hair_cell0.98405891
136MP0002084_abnormal_developmental_patter0.98382123
137MP0002098_abnormal_vibrissa_morphology0.98381942
138MP0001853_heart_inflammation0.95010870
139MP0010030_abnormal_orbit_morphology0.93602134
140MP0001849_ear_inflammation0.91083301
141MP0010771_integument_phenotype0.89867610
142MP0002272_abnormal_nervous_system0.89723904
143MP0008874_decreased_physiological_sensi0.89117041
144MP0008469_abnormal_protein_level0.87866152
145MP0008260_abnormal_autophagy0.87786614
146MP0002067_abnormal_sensory_capabilities0.86709347
147MP0009384_cardiac_valve_regurgitation0.86137208
148MP0002166_altered_tumor_susceptibility0.85829972
149MP0001672_abnormal_embryogenesis/_devel0.84800842
150MP0005380_embryogenesis_phenotype0.84800842
151MP0002332_abnormal_exercise_endurance0.84393787
152MP0001697_abnormal_embryo_size0.82939457
153MP0009046_muscle_twitch0.82510900
154MP0000490_abnormal_crypts_of0.81616409
155MP0002009_preneoplasia0.80963312
156MP0001765_abnormal_ion_homeostasis0.80689692
157MP0000920_abnormal_myelination0.77729176
158MP0009250_abnormal_appendicular_skeleto0.77444070
159MP0000377_abnormal_hair_follicle0.77275204
160MP0001764_abnormal_homeostasis0.76358455
161MP0002006_tumorigenesis0.76072264
162MP0008873_increased_physiological_sensi0.75602070
163MP0005647_abnormal_sex_gland0.74673840
164MP0002177_abnormal_outer_ear0.74401495
165MP0008872_abnormal_physiological_respon0.74314806
166MP0002735_abnormal_chemical_nociception0.74283013
167MP0002019_abnormal_tumor_incidence0.73984050
168MP0000639_abnormal_adrenal_gland0.73945584
169MP0005166_decreased_susceptibility_to0.73876179
170MP0003183_abnormal_peptide_metabolism0.73348268
171MP0008961_abnormal_basal_metabolism0.72061843
172MP0004130_abnormal_muscle_cell0.71094786
173MP0001915_intracranial_hemorrhage0.70470539
174MP0008875_abnormal_xenobiotic_pharmacok0.70176569
175MP0003329_amyloid_beta_deposits0.69800124
176MP0008995_early_reproductive_senescence0.68441520
177MP0000432_abnormal_head_morphology0.68354789
178MP0002233_abnormal_nose_morphology0.66858664
179MP0004782_abnormal_surfactant_physiolog0.65227618
180MP0005248_abnormal_Harderian_gland0.64956831
181MP0002116_abnormal_craniofacial_bone0.63270336
182MP0001340_abnormal_eyelid_morphology0.63208771
183MP0000627_abnormal_mammary_gland0.62637013
184MP0003786_premature_aging0.62282525
185MP0001905_abnormal_dopamine_level0.61648389
186MP0010386_abnormal_urinary_bladder0.61331470
187MP0005621_abnormal_cell_physiology0.60699957
188MP0002282_abnormal_trachea_morphology0.60609398
189MP0003698_abnormal_male_reproductive0.60039152
190MP0003935_abnormal_craniofacial_develop0.60006358
191MP0010368_abnormal_lymphatic_system0.59877670
192MP0001919_abnormal_reproductive_system0.59440009

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)7.09447171
2Elevated erythrocyte sedimentation rate (HP:0003565)4.99145956
3Lip pit (HP:0100267)4.92586116
4Recurrent gram-negative bacterial infections (HP:0005420)4.60151956
5Papillary thyroid carcinoma (HP:0002895)4.52626786
6Cortical dysplasia (HP:0002539)4.42228755
7Premature ovarian failure (HP:0008209)4.40391843
8Chromsome breakage (HP:0040012)4.33255178
9Recurrent abscess formation (HP:0002722)4.16602916
10Breast hypoplasia (HP:0003187)4.09440108
11Birth length less than 3rd percentile (HP:0003561)4.03786002
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97490763
13Shawl scrotum (HP:0000049)3.89911001
14Facial hemangioma (HP:0000329)3.88365654
15Autoimmune thrombocytopenia (HP:0001973)3.81652563
16Infertility (HP:0000789)3.75057508
17Flat capital femoral epiphysis (HP:0003370)3.68679642
18Leukocytosis (HP:0001974)3.68203257
19Patellar aplasia (HP:0006443)3.67448423
20Panhypogammaglobulinemia (HP:0003139)3.64892695
21Adrenal hypoplasia (HP:0000835)3.58928476
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.57033258
23Granulocytopenia (HP:0001913)3.54865147
24Aplasia/Hypoplasia of the patella (HP:0006498)3.54528716
25Autoimmune hemolytic anemia (HP:0001890)3.43091825
26Agammaglobulinemia (HP:0004432)3.42291250
27Gingivitis (HP:0000230)3.39926675
28Periodontitis (HP:0000704)3.38985124
29Aplasia/Hypoplasia of the breasts (HP:0010311)3.38496723
30Breast aplasia (HP:0100783)3.36195790
31Insulin-resistant diabetes mellitus (HP:0000831)3.34038372
32Severe combined immunodeficiency (HP:0004430)3.32474435
33Stomatitis (HP:0010280)3.27545957
34Poikiloderma (HP:0001029)3.26953566
35Eosinophilia (HP:0001880)3.25485735
36Thrombocytosis (HP:0001894)3.24936196
37Attenuation of retinal blood vessels (HP:0007843)3.17355103
38Increased IgE level (HP:0003212)3.14756816
39Abnormality of the labia minora (HP:0012880)3.10189841
40Milia (HP:0001056)3.04331902
41Abnormality of eosinophils (HP:0001879)3.01857356
42Secondary amenorrhea (HP:0000869)3.00892622
43Myositis (HP:0100614)2.94787626
44Meningitis (HP:0001287)2.90473291
45Abnormality of binocular vision (HP:0011514)2.89920059
46Diplopia (HP:0000651)2.89920059
47Chronic otitis media (HP:0000389)2.87650802
48Acute myeloid leukemia (HP:0004808)2.86797455
49Capillary hemangiomas (HP:0005306)2.85840482
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82829163
51Prostate neoplasm (HP:0100787)2.82037474
52Abnormality of the fovea (HP:0000493)2.82001540
53Hemiplegia (HP:0002301)2.77495934
54Papilledema (HP:0001085)2.76224036
55Abnormality of the fingertips (HP:0001211)2.74988554
56Oligodactyly (hands) (HP:0001180)2.72778308
57Cellulitis (HP:0100658)2.72097337
58Recurrent fungal infections (HP:0002841)2.71932345
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.71456159
60Hypoplasia of the fovea (HP:0007750)2.71456159
61Hypergammaglobulinemia (HP:0010702)2.70036418
62Obstructive lung disease (HP:0006536)2.69770681
63Chronic obstructive pulmonary disease (HP:0006510)2.69770681
64Pustule (HP:0200039)2.66558161
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66513716
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.64016742
67Myokymia (HP:0002411)2.63915745
68Abnormality of lateral ventricle (HP:0030047)2.63231206
69Ankle clonus (HP:0011448)2.60915101
70Cerebral palsy (HP:0100021)2.55923779
71Primary amenorrhea (HP:0000786)2.55417002
72Fragile nails (HP:0001808)2.53279768
73Hyperglycemia (HP:0003074)2.52198060
74Atelectasis (HP:0100750)2.49716968
75Hypergonadotropic hypogonadism (HP:0000815)2.49597300
76Combined immunodeficiency (HP:0005387)2.48462526
77Abnormality of the phalanges of the hallux (HP:0010057)2.46123201
78Mediastinal lymphadenopathy (HP:0100721)2.43690333
79Increased cerebral lipofuscin (HP:0011813)2.42138549
80Malnutrition (HP:0004395)2.41701054
81Oligodactyly (HP:0012165)2.40740800
82Parakeratosis (HP:0001036)2.40527932
83Abnormality of the preputium (HP:0100587)2.37038218
84Chronic bronchitis (HP:0004469)2.35114824
85Annular pancreas (HP:0001734)2.34426878
86B lymphocytopenia (HP:0010976)2.34123638
87Eczematoid dermatitis (HP:0000976)2.33855986
88Encephalitis (HP:0002383)2.32701504
89Abnormality of B cell number (HP:0010975)2.32559788
90Prolonged bleeding time (HP:0003010)2.27744708
91Thyroid carcinoma (HP:0002890)2.26652762
92Dyschromatopsia (HP:0007641)2.24944528
93Anterior segment dysgenesis (HP:0007700)2.23175730
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.22197613
95Short thumb (HP:0009778)2.21469417
96Hypertensive crisis (HP:0100735)2.21454364
97Increased IgM level (HP:0003496)2.19851886
98Atrioventricular block (HP:0001678)2.17014587
99Chest pain (HP:0100749)2.16846861
100Pulmonary fibrosis (HP:0002206)2.15657695
101Microvesicular hepatic steatosis (HP:0001414)2.15324841
102Hypotrichosis (HP:0001006)2.15029479
103Congenital stationary night blindness (HP:0007642)2.14997517
104Chin dimple (HP:0010751)2.14368796
105Abnormality of the proximal phalanges of the hand (HP:0009834)2.12862995
106Abnormality of chromosome stability (HP:0003220)2.12215189
107Spinal canal stenosis (HP:0003416)2.11887718
108Absent radius (HP:0003974)2.11743293
109Rhabdomyolysis (HP:0003201)2.11520311
110Tetraplegia (HP:0002445)2.11417064
111Rib fusion (HP:0000902)2.10916966
112Midline defect of the nose (HP:0004122)2.10503874
113Fibular aplasia (HP:0002990)2.10112911
114Status epilepticus (HP:0002133)2.08505442
115Abnormality of the heme biosynthetic pathway (HP:0010472)2.08223119
116Arterial tortuosity (HP:0005116)2.07874589
117Microglossia (HP:0000171)2.07397348
118Sandal gap (HP:0001852)2.07186812
119Aplasia/Hypoplasia of the sternum (HP:0006714)2.07061201
120Meckel diverticulum (HP:0002245)2.06017775
1213-Methylglutaconic aciduria (HP:0003535)2.05879030
122Abnormality of T cell number (HP:0011839)2.05738790
123Absent forearm bone (HP:0003953)2.05060999
124Aplasia involving forearm bones (HP:0009822)2.05060999
125Anosmia (HP:0000458)2.03082115
126Aplasia/Hypoplasia of the thymus (HP:0010515)2.02648927
127Abnormality of chromosome segregation (HP:0002916)2.02090575
128Increased intramyocellular lipid droplets (HP:0012240)2.01921234
129Increased muscle lipid content (HP:0009058)2.01795866
130Abnormality of T cells (HP:0002843)2.01547920
131Oligodontia (HP:0000677)2.01446171
132Recurrent viral infections (HP:0004429)2.01348275
133Chronic mucocutaneous candidiasis (HP:0002728)1.99803965
134Recurrent cutaneous fungal infections (HP:0011370)1.99803965
135Focal motor seizures (HP:0011153)1.99773908
136Sparse scalp hair (HP:0002209)1.99044734
137Sparse lateral eyebrow (HP:0005338)1.98913755
138Blepharitis (HP:0000498)1.97672828
139Onycholysis (HP:0001806)1.97333044
140Poor eye contact (HP:0000817)1.96881952
141Aplasia involving bones of the extremities (HP:0009825)1.95767204
142Aplasia involving bones of the upper limbs (HP:0009823)1.95767204
143Aplasia of the phalanges of the hand (HP:0009802)1.95767204
144Brushfield spots (HP:0001088)1.95604725
145Cerebral hypomyelination (HP:0006808)1.95444513
146Ragged-red muscle fibers (HP:0003200)1.94811239
147Epileptic encephalopathy (HP:0200134)1.94569559
148Fetal akinesia sequence (HP:0001989)1.93802710
149Posterior embryotoxon (HP:0000627)1.93725803
150Sepsis (HP:0100806)1.92399530
151Vasculitis (HP:0002633)1.91520622
152Urticaria (HP:0001025)1.91289543
153Supernumerary spleens (HP:0009799)1.89886178
154Hypochromic anemia (HP:0001931)1.89584820
155Inflammation of the large intestine (HP:0002037)1.88091996
156Abnormality of the labia (HP:0000058)1.87293114
157Duodenal stenosis (HP:0100867)1.86933177
158Small intestinal stenosis (HP:0012848)1.86933177
159Mesangial abnormality (HP:0001966)1.86031648
160Recurrent bacterial skin infections (HP:0005406)1.84923482
161Abnormality of the ileum (HP:0001549)1.84911284
162Clubbing of toes (HP:0100760)1.84504478
163Global brain atrophy (HP:0002283)1.84190318
164Deep palmar crease (HP:0006191)1.83960506
165Abnormality of the line of Schwalbe (HP:0008048)1.83777676
166Myelodysplasia (HP:0002863)1.82737828
167Thoracic kyphosis (HP:0002942)1.82265902
168Abnormality of DNA repair (HP:0003254)1.82249151
169Testicular atrophy (HP:0000029)1.82065949
170Gastrointestinal inflammation (HP:0004386)1.81472972
171Increased serum ferritin (HP:0003281)1.80262293
172Gastrointestinal infarctions (HP:0005244)1.78880929
173Erythema (HP:0010783)1.78456487
174Abnormality of the labia majora (HP:0012881)1.77792562
175Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77067278
176Dicarboxylic aciduria (HP:0003215)1.77067278
177Ectropion (HP:0000656)1.76832698
178J-shaped sella turcica (HP:0002680)1.76116944
179Reduced antithrombin III activity (HP:0001976)1.75686887
180Abnormal number of erythroid precursors (HP:0012131)1.75431000
181Overlapping toe (HP:0001845)1.75330115
182Visual hallucinations (HP:0002367)1.74470286
183Ectopic kidney (HP:0000086)1.73882327
184Abnormality of T cell physiology (HP:0011840)1.73528353
185Absent eyebrow (HP:0002223)1.73074632
186Curly hair (HP:0002212)1.72500887
187Obstructive sleep apnea (HP:0002870)1.72407372
188Epistaxis (HP:0000421)1.71968961
189Vascular tortuosity (HP:0004948)1.71404778
190Hypoplastic pelvis (HP:0008839)1.69701566
191Microtia (HP:0008551)1.68818765
192Aplasia/Hypoplasia of the macula (HP:0008059)1.67720780
193Nail dystrophy (HP:0008404)1.67500050
194Woolly hair (HP:0002224)1.67139390
195Cystic hygroma (HP:0000476)1.67076074
196Popliteal pterygium (HP:0009756)1.66885738
197Impulsivity (HP:0100710)1.66795414
198Bifid tongue (HP:0010297)1.63458307
199Skin pits (HP:0100276)1.63254611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.59434857
2LATS25.08139198
3MAP3K64.41820118
4MAP4K14.12247465
5STK38L3.95518087
6ERBB43.61172206
7TAOK33.07119674
8FES3.05657149
9BCKDK2.91977201
10KSR22.73469312
11TXK2.58771282
12TESK22.56942767
13PLK42.52900995
14PRKCH2.38667985
15MAPKAPK32.34698860
16DAPK22.29557920
17EEF2K2.28947661
18MAP3K112.24097937
19TAOK12.23922405
20STK32.23891388
21MOS2.19884397
22PRKD32.14573261
23TTK2.11557581
24MAP3K132.10402459
25SIK22.08539687
26GRK62.05818191
27TNK22.01150060
28MAP2K32.00176387
29BRAF1.97033904
30SYK1.92179739
31CDK81.90007723
32CDC71.87912167
33RAF11.85458288
34BMPR21.81210344
35CAMKK11.81066157
36DAPK11.79190467
37MAP3K91.79039108
38ICK1.72256785
39TBK11.71302472
40RIPK41.70652721
41MUSK1.68733599
42CHEK21.67269506
43DYRK21.66776533
44ITK1.53683230
45CSF1R1.50412606
46MELK1.45728978
47ZAP701.44291733
48KDR1.44095767
49KIT1.37645372
50ARAF1.36989075
51CAMKK21.35818568
52MAPKAPK51.31769734
53CDK91.29922419
54LCK1.28290756
55BTK1.28010844
56NME21.27519862
57DMPK1.27268494
58JAK31.24966534
59MAP2K61.24648214
60STK241.18806846
61MAPK121.18123651
62PIM21.16500107
63NEK21.15850713
64ABL21.15812365
65PRPF4B1.15279663
66STK381.10296359
67PRKD21.08866752
68MAPK131.05944393
69CSK1.05686478
70MAP3K41.05371292
71PLK11.03444401
72TYRO30.96973242
73STK100.96919753
74PRKCQ0.95652057
75CDK30.93101158
76MARK10.92689101
77BLK0.90140254
78PDK10.89087096
79AURKB0.85342723
80ADRBK10.85311483
81RPS6KB20.83657753
82TEC0.81810911
83GRK70.81518132
84PAK60.80254465
85MINK10.79089312
86IKBKB0.79055409
87KSR10.76940460
88IKBKE0.76606526
89MAP2K40.76567613
90HCK0.75168212
91CSNK1G10.75141033
92MAP3K50.74941792
93MAP3K80.71858185
94MAP3K10.70674730
95RPS6KA20.70671962
96MAP2K70.68512350
97NTRK30.68126436
98RET0.68052543
99LYN0.67833336
100AKT30.67212073
101MAP3K20.65297871
102UHMK10.65263387
103RPS6KC10.65099927
104RPS6KL10.65099927
105MAPK150.64411986
106AURKA0.63355695
107PBK0.63202404
108ACVR1B0.61714504
109NTRK20.61175112
110BUB10.61145816
111VRK20.60467292
112PRKAA20.60271810
113RPS6KA60.58805180
114NLK0.58375734
115MAP3K140.56853507
116PDPK10.56510945
117NUAK10.56074216
118DYRK1B0.55393360
119WNK10.53393065
120ABL10.53270891
121TYK20.52959838
122IRAK20.52787945
123HIPK20.52462632
124PRKAA10.52207583
125CSNK1G20.51713884
126CDK70.51474680
127MST1R0.49733052
128PIK3CG0.48552447
129JAK10.47868432
130WNK40.47852720
131BRSK20.46941710
132ATM0.46925532
133CHEK10.46445415
134PLK30.45595003
135TAOK20.45259856
136TRPM70.44283817
137RPS6KA40.44153146
138MAPK30.43674515
139CDK40.41902750
140CSNK1G30.41814706
141SCYL20.41750085
142PRKCD0.41524934
143EPHB10.41321266
144CDK120.40530897
145PKN10.40481398
146MARK20.39187724
147FYN0.38892176
148MAPK110.38382907
149CCNB10.37358577
150CDK50.36798787
151ADRBK20.35574942
152MAPK70.34558708
153MAP3K120.33420066
154STK110.32994949
155MAPK40.32061235
156BRSK10.29665698
157CSNK1A1L0.29389165
158MAP2K10.27540255
159CDK10.27177606
160CHUK0.26349852
161CDK20.25651839
162CDK60.24308830
163VRK10.24068692
164DYRK30.23930045
165CSNK1D0.23403457
166PIM10.22300178
167FRK0.21175224
168SGK20.20884588
169EPHA30.18372016
170WEE10.18134431
171EPHA40.17460673
172AKT10.16947659
173JAK20.16064379
174CAMK2A0.15923142
175MAPK100.13829142
176RPS6KA10.13599696

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.64770069
2Primary immunodeficiency_Homo sapiens_hsa053403.63989323
3Basal transcription factors_Homo sapiens_hsa030223.57673446
4Ovarian steroidogenesis_Homo sapiens_hsa049133.39928868
5RNA degradation_Homo sapiens_hsa030183.05155482
6Vitamin B6 metabolism_Homo sapiens_hsa007503.00026410
7Graft-versus-host disease_Homo sapiens_hsa053322.83286546
8Allograft rejection_Homo sapiens_hsa053302.81149698
9Circadian rhythm_Homo sapiens_hsa047102.76755191
10Autoimmune thyroid disease_Homo sapiens_hsa053202.74726689
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.62075383
12Type I diabetes mellitus_Homo sapiens_hsa049402.51511537
13RNA polymerase_Homo sapiens_hsa030202.45953620
14Pancreatic cancer_Homo sapiens_hsa052122.27734203
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27437739
16Linoleic acid metabolism_Homo sapiens_hsa005912.27341512
17Viral myocarditis_Homo sapiens_hsa054162.17125211
18Fanconi anemia pathway_Homo sapiens_hsa034602.16807362
19Staphylococcus aureus infection_Homo sapiens_hsa051502.16113192
20Dorso-ventral axis formation_Homo sapiens_hsa043202.11589084
21Leishmaniasis_Homo sapiens_hsa051402.11019925
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.08266938
23Oocyte meiosis_Homo sapiens_hsa041142.08169894
24TGF-beta signaling pathway_Homo sapiens_hsa043501.99795157
25Homologous recombination_Homo sapiens_hsa034401.95304514
26p53 signaling pathway_Homo sapiens_hsa041151.91525342
27Ether lipid metabolism_Homo sapiens_hsa005651.90205682
28GnRH signaling pathway_Homo sapiens_hsa049121.87490733
29Rheumatoid arthritis_Homo sapiens_hsa053231.74047473
30RNA transport_Homo sapiens_hsa030131.65982915
31MicroRNAs in cancer_Homo sapiens_hsa052061.62052063
32Antigen processing and presentation_Homo sapiens_hsa046121.61024055
33Nicotine addiction_Homo sapiens_hsa050331.60299091
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.58253304
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58189862
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57758765
37Prolactin signaling pathway_Homo sapiens_hsa049171.56082497
38Synaptic vesicle cycle_Homo sapiens_hsa047211.54293809
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53755785
40T cell receptor signaling pathway_Homo sapiens_hsa046601.53742157
41Phototransduction_Homo sapiens_hsa047441.51432763
42Sphingolipid metabolism_Homo sapiens_hsa006001.48643591
43Long-term potentiation_Homo sapiens_hsa047201.48049727
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47345887
45B cell receptor signaling pathway_Homo sapiens_hsa046621.45841543
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.45415879
47Hematopoietic cell lineage_Homo sapiens_hsa046401.43910044
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42854886
49Choline metabolism in cancer_Homo sapiens_hsa052311.40513325
50Osteoclast differentiation_Homo sapiens_hsa043801.38759199
51Tuberculosis_Homo sapiens_hsa051521.36694605
52Colorectal cancer_Homo sapiens_hsa052101.31797421
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31560954
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31246799
55Acute myeloid leukemia_Homo sapiens_hsa052211.30456661
56mTOR signaling pathway_Homo sapiens_hsa041501.29831361
57Hippo signaling pathway_Homo sapiens_hsa043901.29767494
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29372387
59Asthma_Homo sapiens_hsa053101.28151548
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.26371854
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24190933
62Malaria_Homo sapiens_hsa051441.19973740
63Renal cell carcinoma_Homo sapiens_hsa052111.19259989
64Endometrial cancer_Homo sapiens_hsa052131.16588587
65Adherens junction_Homo sapiens_hsa045201.16517072
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16374661
67VEGF signaling pathway_Homo sapiens_hsa043701.15218536
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13526209
69Measles_Homo sapiens_hsa051621.08905182
70Thyroid cancer_Homo sapiens_hsa052161.08733365
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04723266
72Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02745699
73Morphine addiction_Homo sapiens_hsa050321.00341138
74Pertussis_Homo sapiens_hsa051331.00016638
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99874165
76Hedgehog signaling pathway_Homo sapiens_hsa043400.99659963
77Legionellosis_Homo sapiens_hsa051340.97690451
78Circadian entrainment_Homo sapiens_hsa047130.97267362
79Non-homologous end-joining_Homo sapiens_hsa034500.96960424
80Bladder cancer_Homo sapiens_hsa052190.96095886
81Small cell lung cancer_Homo sapiens_hsa052220.95261959
82mRNA surveillance pathway_Homo sapiens_hsa030150.94852874
83Non-small cell lung cancer_Homo sapiens_hsa052230.94302480
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90859458
85Cholinergic synapse_Homo sapiens_hsa047250.89246197
86Long-term depression_Homo sapiens_hsa047300.89056416
87GABAergic synapse_Homo sapiens_hsa047270.88402121
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88080482
89FoxO signaling pathway_Homo sapiens_hsa040680.87573117
90Nucleotide excision repair_Homo sapiens_hsa034200.87500728
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86962396
92Base excision repair_Homo sapiens_hsa034100.86582511
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85678266
94Chemokine signaling pathway_Homo sapiens_hsa040620.84766053
95Ras signaling pathway_Homo sapiens_hsa040140.83702411
96Phagosome_Homo sapiens_hsa041450.83485157
97Prostate cancer_Homo sapiens_hsa052150.83169036
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82708117
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.82041167
100Basal cell carcinoma_Homo sapiens_hsa052170.82038288
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.78591339
102Platelet activation_Homo sapiens_hsa046110.78126957
103Regulation of autophagy_Homo sapiens_hsa041400.77936883
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77122512
105African trypanosomiasis_Homo sapiens_hsa051430.75702196
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.75647798
107Olfactory transduction_Homo sapiens_hsa047400.73336780
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71466262
109Inositol phosphate metabolism_Homo sapiens_hsa005620.70512905
110Oxytocin signaling pathway_Homo sapiens_hsa049210.70116378
111Systemic lupus erythematosus_Homo sapiens_hsa053220.69615274
112Salivary secretion_Homo sapiens_hsa049700.68805594
113Taste transduction_Homo sapiens_hsa047420.68222366
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67831923
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67621405
116Wnt signaling pathway_Homo sapiens_hsa043100.65670695
117Chronic myeloid leukemia_Homo sapiens_hsa052200.65088460
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.64936706
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.64497419
120HTLV-I infection_Homo sapiens_hsa051660.64419287
121Arachidonic acid metabolism_Homo sapiens_hsa005900.63925366
122Alcoholism_Homo sapiens_hsa050340.63448493
123Calcium signaling pathway_Homo sapiens_hsa040200.61998256
124ErbB signaling pathway_Homo sapiens_hsa040120.61366937
125MAPK signaling pathway_Homo sapiens_hsa040100.59271398
126Estrogen signaling pathway_Homo sapiens_hsa049150.57577274
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.57541556
128Melanoma_Homo sapiens_hsa052180.56576813
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55492151
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.54513123
131Purine metabolism_Homo sapiens_hsa002300.54342452
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51932527
133Other glycan degradation_Homo sapiens_hsa005110.51878295
134Influenza A_Homo sapiens_hsa051640.51861604
135Pyrimidine metabolism_Homo sapiens_hsa002400.47371623
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47257188
137Dopaminergic synapse_Homo sapiens_hsa047280.46796498
138Lysosome_Homo sapiens_hsa041420.46467591
139Hepatitis B_Homo sapiens_hsa051610.45923475
140Serotonergic synapse_Homo sapiens_hsa047260.45903784
141Hepatitis C_Homo sapiens_hsa051600.45860896
142Amphetamine addiction_Homo sapiens_hsa050310.45640583
143Glioma_Homo sapiens_hsa052140.44793508
144Shigellosis_Homo sapiens_hsa051310.44383054
145Pathways in cancer_Homo sapiens_hsa052000.44278058
146Ribosome_Homo sapiens_hsa030100.43231403
147Epstein-Barr virus infection_Homo sapiens_hsa051690.43223116
148Rap1 signaling pathway_Homo sapiens_hsa040150.42191351
149Folate biosynthesis_Homo sapiens_hsa007900.41980426
150Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41312404
151Retinol metabolism_Homo sapiens_hsa008300.41088665
152Notch signaling pathway_Homo sapiens_hsa043300.41077188
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38796053
154Herpes simplex infection_Homo sapiens_hsa051680.36935636
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36893383
156Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36166184
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35925777
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.35888787
159Histidine metabolism_Homo sapiens_hsa003400.35270323
160Mismatch repair_Homo sapiens_hsa034300.34090302
161Lysine degradation_Homo sapiens_hsa003100.33317617
162cAMP signaling pathway_Homo sapiens_hsa040240.32919954
163Vascular smooth muscle contraction_Homo sapiens_hsa042700.32318364
164Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31984732
165Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31982257
166Tight junction_Homo sapiens_hsa045300.31850407
167Melanogenesis_Homo sapiens_hsa049160.31723109
168Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31141213
169Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27033615
170Amoebiasis_Homo sapiens_hsa051460.25724595
171Glutamatergic synapse_Homo sapiens_hsa047240.24470860
172DNA replication_Homo sapiens_hsa030300.22312849

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