TFAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.99066105
2DNA deamination (GO:0045006)5.00794336
3transcription from mitochondrial promoter (GO:0006390)4.83294455
4proline biosynthetic process (GO:0006561)4.66230164
5DNA unwinding involved in DNA replication (GO:0006268)4.55704056
6formation of translation preinitiation complex (GO:0001731)4.53623858
7replication fork processing (GO:0031297)4.35177350
8DNA strand elongation involved in DNA replication (GO:0006271)4.29884618
9telomere maintenance via semi-conservative replication (GO:0032201)4.29038943
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.20590587
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.20396236
12protein localization to kinetochore (GO:0034501)4.18700603
13DNA strand elongation (GO:0022616)4.09751245
14indolalkylamine metabolic process (GO:0006586)4.08809818
15tryptophan catabolic process (GO:0006569)4.07068160
16indole-containing compound catabolic process (GO:0042436)4.07068160
17indolalkylamine catabolic process (GO:0046218)4.07068160
18somatic hypermutation of immunoglobulin genes (GO:0016446)4.05458822
19somatic diversification of immune receptors via somatic mutation (GO:0002566)4.05458822
20embryonic process involved in female pregnancy (GO:0060136)4.03087649
21mitochondrial DNA metabolic process (GO:0032042)3.99783170
22kynurenine metabolic process (GO:0070189)3.95519027
23DNA replication initiation (GO:0006270)3.88421342
24water-soluble vitamin biosynthetic process (GO:0042364)3.84727263
25histone H4-K12 acetylation (GO:0043983)3.80853985
26negative regulation of RNA splicing (GO:0033119)3.78407610
27viral mRNA export from host cell nucleus (GO:0046784)3.77819273
28viral transcription (GO:0019083)3.75433406
29negative regulation of mRNA processing (GO:0050686)3.70694332
30regulation of hippo signaling (GO:0035330)3.68816416
31ribosome biogenesis (GO:0042254)3.65513227
32fucose catabolic process (GO:0019317)3.62653942
33L-fucose metabolic process (GO:0042354)3.62653942
34L-fucose catabolic process (GO:0042355)3.62653942
35translational termination (GO:0006415)3.60092255
36regulation of translational fidelity (GO:0006450)3.59437450
37heterochromatin organization (GO:0070828)3.58216019
38telomere maintenance via recombination (GO:0000722)3.55698202
39dosage compensation (GO:0007549)3.54400088
40DNA duplex unwinding (GO:0032508)3.52766423
41detection of light stimulus involved in visual perception (GO:0050908)3.52355064
42detection of light stimulus involved in sensory perception (GO:0050962)3.52355064
43mitotic sister chromatid segregation (GO:0000070)3.51606859
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.50457989
45pseudouridine synthesis (GO:0001522)3.49539308
46tryptophan metabolic process (GO:0006568)3.49130437
47sulfation (GO:0051923)3.49002768
48establishment of apical/basal cell polarity (GO:0035089)3.48992679
49DNA geometric change (GO:0032392)3.48693369
50tachykinin receptor signaling pathway (GO:0007217)3.48060471
51ribosomal small subunit assembly (GO:0000028)3.47361088
52folic acid-containing compound biosynthetic process (GO:0009396)3.46906163
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.45963498
54base-excision repair (GO:0006284)3.43766082
55negative regulation of telomere maintenance (GO:0032205)3.42008698
56DNA replication checkpoint (GO:0000076)3.40153784
57mitotic G1 DNA damage checkpoint (GO:0031571)3.40148002
58mitotic nuclear envelope disassembly (GO:0007077)3.38334384
59ribosomal small subunit biogenesis (GO:0042274)3.37891370
60mitotic recombination (GO:0006312)3.35771579
61regulation of gene silencing by RNA (GO:0060966)3.34581819
62regulation of posttranscriptional gene silencing (GO:0060147)3.34581819
63regulation of gene silencing by miRNA (GO:0060964)3.34581819
64translational initiation (GO:0006413)3.33449799
65rRNA catabolic process (GO:0016075)3.33152857
66negative regulation of transcription regulatory region DNA binding (GO:2000678)3.33021193
67ribonucleoprotein complex biogenesis (GO:0022613)3.32149328
68maturation of SSU-rRNA (GO:0030490)3.31269474
69translational elongation (GO:0006414)3.31251285
70DNA replication-dependent nucleosome organization (GO:0034723)3.31056095
71DNA replication-dependent nucleosome assembly (GO:0006335)3.31056095
72protein localization to chromosome, centromeric region (GO:0071459)3.29916419
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29524081
74termination of RNA polymerase II transcription (GO:0006369)3.28109218
75mRNA cleavage (GO:0006379)3.26993998
76proline metabolic process (GO:0006560)3.25893025
77pre-miRNA processing (GO:0031054)3.25540979
78spliceosomal tri-snRNP complex assembly (GO:0000244)3.23743491
79telomere maintenance via telomere lengthening (GO:0010833)3.22583147
80regulation of double-strand break repair via homologous recombination (GO:0010569)3.21721360
81adaptation of signaling pathway (GO:0023058)3.18721219
82negative regulation of mRNA metabolic process (GO:1903312)3.17660418
83nuclear pore organization (GO:0006999)3.15840384
84IMP biosynthetic process (GO:0006188)3.15047655
85trophectodermal cell differentiation (GO:0001829)3.14139637
86mitochondrial RNA metabolic process (GO:0000959)3.14125511
87sister chromatid segregation (GO:0000819)3.13886565
88nuclear pore complex assembly (GO:0051292)3.12471544
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12020402
90DNA methylation involved in gamete generation (GO:0043046)3.11673086
91regulation of double-strand break repair (GO:2000779)3.09947939
92mitochondrial DNA replication (GO:0006264)3.09684248
93DNA strand renaturation (GO:0000733)3.08867197
94membrane disassembly (GO:0030397)3.08651137
95nuclear envelope disassembly (GO:0051081)3.08651137
96regulation of nuclear cell cycle DNA replication (GO:0033262)3.05751060
97indole-containing compound metabolic process (GO:0042430)3.04776718
98rRNA processing (GO:0006364)3.04632344
99piRNA metabolic process (GO:0034587)3.02644587
100rRNA transcription (GO:0009303)3.02416233
101cellular response to ATP (GO:0071318)3.02291189
102cell proliferation in forebrain (GO:0021846)2.96508322
103G1 DNA damage checkpoint (GO:0044783)2.96488130
104double-strand break repair via homologous recombination (GO:0000724)2.96210924
105recombinational repair (GO:0000725)2.95976470
106oxidative demethylation (GO:0070989)2.95367226
107rRNA metabolic process (GO:0016072)2.93757868
108DNA topological change (GO:0006265)2.92987908
109mitotic G1/S transition checkpoint (GO:0044819)2.92349989
110chromatin assembly (GO:0031497)2.92190999
111cornea development in camera-type eye (GO:0061303)2.92164530
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91211681
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.91211681
114NADH dehydrogenase complex assembly (GO:0010257)2.91211681
115intracellular estrogen receptor signaling pathway (GO:0030520)2.91150474
116peptidyl-arginine omega-N-methylation (GO:0035247)2.91124968
117positive regulation of protein homooligomerization (GO:0032464)2.90351924
118RNA export from nucleus (GO:0006405)2.87063279
119regulation of mesoderm development (GO:2000380)2.85966171
120establishment of monopolar cell polarity (GO:0061162)2.85931088
121establishment or maintenance of monopolar cell polarity (GO:0061339)2.85931088
122SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85230672
123histone arginine methylation (GO:0034969)2.85087818
124maturation of 5.8S rRNA (GO:0000460)2.84583947
125mRNA export from nucleus (GO:0006406)2.83840620
126RNA splicing, via transesterification reactions (GO:0000375)2.83648743
127viral life cycle (GO:0019058)2.83521011
128DNA double-strand break processing (GO:0000729)2.83226970
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82666222
130response to pheromone (GO:0019236)2.82591060
131RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82539735
132mRNA splicing, via spliceosome (GO:0000398)2.82539735
133regulation of sister chromatid cohesion (GO:0007063)2.82286462
134spliceosomal snRNP assembly (GO:0000387)2.81603623
135nuclear-transcribed mRNA catabolic process (GO:0000956)2.81536894
136kinetochore assembly (GO:0051382)2.80762553
137protein polyglutamylation (GO:0018095)2.80140639
138somite development (GO:0061053)2.78144709
139reflex (GO:0060004)2.77617396
140amine catabolic process (GO:0009310)2.77529451
141cellular biogenic amine catabolic process (GO:0042402)2.77529451
142negative regulation of systemic arterial blood pressure (GO:0003085)2.77145189
143protein complex biogenesis (GO:0070271)2.77136399
144cellular ketone body metabolic process (GO:0046950)2.73626495
145reciprocal DNA recombination (GO:0035825)2.73434949
146reciprocal meiotic recombination (GO:0007131)2.73434949
147snRNA transcription (GO:0009301)2.73246795
148mannosylation (GO:0097502)2.73242768
149preassembly of GPI anchor in ER membrane (GO:0016254)2.70819767
150primary amino compound metabolic process (GO:1901160)2.70818959
151epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68979613
152neural tube formation (GO:0001841)2.68870576
153kidney morphogenesis (GO:0060993)2.68023030
154spinal cord motor neuron differentiation (GO:0021522)2.67893106
155synaptic transmission, cholinergic (GO:0007271)2.65462478
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65436713
157regulation of telomere maintenance (GO:0032204)2.65432466
158regulation of rhodopsin mediated signaling pathway (GO:0022400)2.63949887
159mitochondrial respiratory chain complex assembly (GO:0033108)2.60397900
160rhodopsin mediated signaling pathway (GO:0016056)2.60357702
161purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.57881610
1623-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.57881610
163protein K11-linked deubiquitination (GO:0035871)2.56958469
164serotonin metabolic process (GO:0042428)2.53993910
165positive regulation of digestive system process (GO:0060456)2.52327652
166ketone body metabolic process (GO:1902224)2.51153517
167multicellular organism reproduction (GO:0032504)2.50260828
168axoneme assembly (GO:0035082)2.49998639
169respiratory chain complex IV assembly (GO:0008535)2.49806207
170tRNA modification (GO:0006400)2.49089953
171gamma-aminobutyric acid transport (GO:0015812)2.45710514
172NAD biosynthetic process (GO:0009435)2.43315639
173behavioral response to ethanol (GO:0048149)2.42099903
174flavonoid metabolic process (GO:0009812)2.41754139
175negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.41014344
176positive regulation of fatty acid oxidation (GO:0046321)2.40934845
177negative regulation of astrocyte differentiation (GO:0048712)2.40494397
178regulation of acrosome reaction (GO:0060046)2.40350158
179peptidyl-histidine modification (GO:0018202)2.39195257
180protein K6-linked ubiquitination (GO:0085020)2.37860991
181meiotic chromosome segregation (GO:0045132)2.37836935
182embryonic epithelial tube formation (GO:0001838)2.35723049
183protein-cofactor linkage (GO:0018065)2.34798597
184cAMP catabolic process (GO:0006198)2.34653397
185photoreceptor cell development (GO:0042461)2.34527023
186endoderm formation (GO:0001706)2.33461630
187ncRNA catabolic process (GO:0034661)2.33290719
188neuronal action potential (GO:0019228)2.32417933
189positive regulation of fatty acid transport (GO:2000193)2.32324440
190negative regulation of reactive oxygen species metabolic process (GO:2000378)2.31991223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14034441
2EZH2_22144423_ChIP-Seq_EOC_Human4.05233521
3ZNF274_21170338_ChIP-Seq_K562_Hela3.83615535
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.82112425
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.46770022
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.31512806
7VDR_22108803_ChIP-Seq_LS180_Human3.26815753
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.26638696
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87135902
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87114554
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79704465
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69076277
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59705212
14* MYC_22102868_ChIP-Seq_BL_Human2.59375848
15GBX2_23144817_ChIP-Seq_PC3_Human2.55421197
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49548791
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47079236
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.43152580
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.43152580
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.43152580
21EWS_26573619_Chip-Seq_HEK293_Human2.36982966
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.35804630
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22736712
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14699997
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11050880
26VDR_21846776_ChIP-Seq_THP-1_Human2.03048527
27FUS_26573619_Chip-Seq_HEK293_Human2.02171424
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00338204
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98328833
30IGF1R_20145208_ChIP-Seq_DFB_Human1.94169580
31XRN2_22483619_ChIP-Seq_HELA_Human1.93307829
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91200337
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87803726
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84178557
35* ETS1_20019798_ChIP-Seq_JURKAT_Human1.83964857
36IRF1_19129219_ChIP-ChIP_H3396_Human1.82943999
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.80437221
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79713063
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78083913
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.77731900
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76472299
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.75763321
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73553330
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70269424
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67801170
46MYC_18940864_ChIP-ChIP_HL60_Human1.66747476
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66252066
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66007068
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65930908
50ER_23166858_ChIP-Seq_MCF-7_Human1.65454421
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64163355
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62865660
53P300_19829295_ChIP-Seq_ESCs_Human1.62362672
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60541328
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.60499782
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60345786
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59478971
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.58381628
59TAF15_26573619_Chip-Seq_HEK293_Human1.57893584
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55567934
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55321024
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55300032
63GABP_19822575_ChIP-Seq_HepG2_Human1.53699221
64TP53_22573176_ChIP-Seq_HFKS_Human1.52914251
65TTF2_22483619_ChIP-Seq_HELA_Human1.52533736
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51610627
67REST_21632747_ChIP-Seq_MESCs_Mouse1.51396577
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50906578
69* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49210819
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48990062
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.48500765
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.48331359
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.47799145
74VDR_23849224_ChIP-Seq_CD4+_Human1.46257987
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45663341
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44733855
77RNF2_27304074_Chip-Seq_NSC_Mouse1.44109974
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.43899490
79FOXP3_21729870_ChIP-Seq_TREG_Human1.43755008
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43535864
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42931325
82BCAT_22108803_ChIP-Seq_LS180_Human1.42279538
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41353822
84STAT3_23295773_ChIP-Seq_U87_Human1.40829981
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.40157086
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40078075
87DCP1A_22483619_ChIP-Seq_HELA_Human1.39791770
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39091752
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38426472
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38121486
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37994030
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37840051
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37790455
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.36973195
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36957987
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36189190
97* KDM5A_27292631_Chip-Seq_BREAST_Human1.35899224
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34893364
99TCF4_23295773_ChIP-Seq_U87_Human1.34576284
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.34570138
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33991392
102CBP_20019798_ChIP-Seq_JUKART_Human1.33991392
103CIITA_25753668_ChIP-Seq_RAJI_Human1.32069825
104ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30534114
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30011345
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29730253
107NCOR_22424771_ChIP-Seq_293T_Human1.27963420
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27284231
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26934535
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26560872
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.25599466
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25321447
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.24373594
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24071605
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23920022
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23484281
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23482232
118EED_16625203_ChIP-ChIP_MESCs_Mouse1.23015385
119NANOG_21062744_ChIP-ChIP_HESCs_Human1.22256314
120TCF7_22412390_ChIP-Seq_EML_Mouse1.19335629
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.18910641
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18910641
123AR_21909140_ChIP-Seq_LNCAP_Human1.18394473
124AR_25329375_ChIP-Seq_VCAP_Human1.17599287
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17486395
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17090833
127ERA_21632823_ChIP-Seq_H3396_Human1.16796682
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16191621
129AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16094793
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15216888
131* HOXB7_26014856_ChIP-Seq_BT474_Human1.14977304
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13851068
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11928971
134POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11789625
135PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11470545
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11450948
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10351204
138JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09681966
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09469958
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09469958
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.08883676
142TCF4_22108803_ChIP-Seq_LS180_Human1.08728542
143NANOG_19829295_ChIP-Seq_ESCs_Human1.08647659
144SOX2_19829295_ChIP-Seq_ESCs_Human1.08647659
145SMAD4_21799915_ChIP-Seq_A2780_Human1.07743278
146AR_21572438_ChIP-Seq_LNCaP_Human1.07281046
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06208541
148* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06087038
149NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05842687
150EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04860628
151RUNX2_22187159_ChIP-Seq_PCA_Human1.04682947
152EZH2_27294783_Chip-Seq_ESCs_Mouse1.03606295
153ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03504004
154KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03247944
155ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03232973
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03128693
157TFEB_21752829_ChIP-Seq_HELA_Human1.02634854
158POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02090469
159AR_20517297_ChIP-Seq_VCAP_Human1.02027030
160PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01592303
161* ELK3_25401928_ChIP-Seq_HUVEC_Human1.00272455
162CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99990322
163BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99875924
164PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99866723
165ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99775567
166NANOG_20526341_ChIP-Seq_ESCs_Human0.99725465
167SMAD4_21741376_ChIP-Seq_EPCs_Human0.99672473
168SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99284682
169OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99181193
170KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98534642
171CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98293401
172SMAD3_21741376_ChIP-Seq_EPCs_Human0.98039227
173SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97741563
174PIAS1_25552417_ChIP-Seq_VCAP_Human0.97666277
175YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97358445
176DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97350180
177* UTX_26944678_Chip-Seq_JUKART_Human0.97335837
178TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96892243
179SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96364661
180TAF2_19829295_ChIP-Seq_ESCs_Human0.96027020
181* MAF_26560356_Chip-Seq_TH1_Human0.95906186
182MYC_19829295_ChIP-Seq_ESCs_Human0.95859811
183NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95842907
184MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95524835
185SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94783524
186FLI1_21867929_ChIP-Seq_TH2_Mouse0.94774070
187SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94368597
188ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94357392
189P53_21459846_ChIP-Seq_SAOS-2_Human0.94228332
190POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92889551
191TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92322343
192FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90726836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.92959102
2MP0010094_abnormal_chromosome_stability3.59688817
3MP0004957_abnormal_blastocyst_morpholog3.50542586
4MP0003693_abnormal_embryo_hatching3.13115029
5MP0003111_abnormal_nucleus_morphology3.01980109
6MP0010030_abnormal_orbit_morphology2.97819858
7MP0003646_muscle_fatigue2.92877656
8MP0003077_abnormal_cell_cycle2.81799648
9MP0003195_calcinosis2.81146278
10MP0003136_yellow_coat_color2.57206048
11MP0005646_abnormal_pituitary_gland2.55618099
12MP0002396_abnormal_hematopoietic_system2.53331852
13MP0009278_abnormal_bone_marrow2.51365348
14MP0001968_abnormal_touch/_nociception2.49968220
15MP0010352_gastrointestinal_tract_polyps2.49386727
16MP0008058_abnormal_DNA_repair2.41594327
17MP0005551_abnormal_eye_electrophysiolog2.32354626
18MP0002736_abnormal_nociception_after2.11661483
19MP0008872_abnormal_physiological_respon2.09967947
20MP0000490_abnormal_crypts_of2.07883216
21MP0000631_abnormal_neuroendocrine_gland2.07156689
22MP0003890_abnormal_embryonic-extraembry2.01868431
23MP0002653_abnormal_ependyma_morphology2.01241039
24MP0000350_abnormal_cell_proliferation2.00708854
25MP0001485_abnormal_pinna_reflex1.98147892
26MP0005645_abnormal_hypothalamus_physiol1.97439138
27MP0005075_abnormal_melanosome_morpholog1.97039604
28MP0000372_irregular_coat_pigmentation1.94683090
29MP0008932_abnormal_embryonic_tissue1.91821798
30MP0005397_hematopoietic_system_phenotyp1.88909533
31MP0001545_abnormal_hematopoietic_system1.88909533
32MP0001986_abnormal_taste_sensitivity1.88241213
33MP0006292_abnormal_olfactory_placode1.86075918
34MP0003786_premature_aging1.85918703
35MP0008007_abnormal_cellular_replicative1.83543431
36MP0001730_embryonic_growth_arrest1.82311493
37MP0002102_abnormal_ear_morphology1.81822321
38MP0005380_embryogenesis_phenotype1.81196818
39MP0001672_abnormal_embryogenesis/_devel1.81196818
40MP0002938_white_spotting1.78697563
41MP0002085_abnormal_embryonic_tissue1.71819274
42MP0002084_abnormal_developmental_patter1.71446235
43MP0001697_abnormal_embryo_size1.69644385
44MP0002876_abnormal_thyroid_physiology1.69278858
45MP0002086_abnormal_extraembryonic_tissu1.68750181
46MP0004197_abnormal_fetal_growth/weight/1.66063731
47MP0001293_anophthalmia1.64573270
48MP0004885_abnormal_endolymph1.63779040
49MP0002160_abnormal_reproductive_system1.61850310
50MP0003984_embryonic_growth_retardation1.60742864
51MP0002138_abnormal_hepatobiliary_system1.60223930
52MP0002088_abnormal_embryonic_growth/wei1.57964461
53MP0004264_abnormal_extraembryonic_tissu1.55238813
54MP0004145_abnormal_muscle_electrophysio1.51987238
55MP0004043_abnormal_pH_regulation1.51454907
56MP0003283_abnormal_digestive_organ1.51128577
57MP0002638_abnormal_pupillary_reflex1.47488692
58MP0009745_abnormal_behavioral_response1.47310739
59MP0005389_reproductive_system_phenotype1.46943954
60MP0005076_abnormal_cell_differentiation1.46290712
61MP0004142_abnormal_muscle_tone1.46040863
62MP0002163_abnormal_gland_morphology1.45430855
63MP0002080_prenatal_lethality1.44357967
64MP0005253_abnormal_eye_physiology1.43561215
65MP0003119_abnormal_digestive_system1.42843372
66MP0002019_abnormal_tumor_incidence1.39822104
67MP0006072_abnormal_retinal_apoptosis1.39134314
68MP0002837_dystrophic_cardiac_calcinosis1.38710965
69MP0004133_heterotaxia1.38451287
70MP0002928_abnormal_bile_duct1.37629920
71MP0002249_abnormal_larynx_morphology1.36043180
72MP0000313_abnormal_cell_death1.35775509
73MP0003567_abnormal_fetal_cardiomyocyte1.35576000
74MP0008995_early_reproductive_senescence1.35571422
75MP0002735_abnormal_chemical_nociception1.30963804
76MP0000427_abnormal_hair_cycle1.30342322
77MP0005174_abnormal_tail_pigmentation1.29507616
78MP0001873_stomach_inflammation1.29444201
79MP0010307_abnormal_tumor_latency1.27634610
80MP0001919_abnormal_reproductive_system1.27156041
81MP0004808_abnormal_hematopoietic_stem1.25047050
82MP0003763_abnormal_thymus_physiology1.24953017
83MP0001501_abnormal_sleep_pattern1.24556850
84MP0003787_abnormal_imprinting1.23222757
85MP0009333_abnormal_splenocyte_physiolog1.19795933
86MP0009046_muscle_twitch1.19562075
87MP0002272_abnormal_nervous_system1.19363408
88MP0003123_paternal_imprinting1.17369185
89MP0006276_abnormal_autonomic_nervous1.15717498
90MP0000703_abnormal_thymus_morphology1.15274404
91MP0003718_maternal_effect1.12791541
92MP0009697_abnormal_copulation1.12487863
93MP0002234_abnormal_pharynx_morphology1.11848024
94MP0003705_abnormal_hypodermis_morpholog1.10055277
95MP0002932_abnormal_joint_morphology1.09745616
96MP0000689_abnormal_spleen_morphology1.08390514
97MP0008877_abnormal_DNA_methylation1.08089200
98MP0002398_abnormal_bone_marrow1.06575275
99MP0002557_abnormal_social/conspecific_i1.05799028
100MP0002722_abnormal_immune_system1.03940514
101MP0005084_abnormal_gallbladder_morpholo1.03693098
102MP0002111_abnormal_tail_morphology1.02292653
103MP0000049_abnormal_middle_ear1.01372082
104MP0003937_abnormal_limbs/digits/tail_de1.01137596
105MP0000383_abnormal_hair_follicle1.00468961
106MP0005195_abnormal_posterior_eye1.00434166
107MP0010386_abnormal_urinary_bladder0.99860431
108MP0001486_abnormal_startle_reflex0.98045775
109MP0009053_abnormal_anal_canal0.97744471
110MP0001963_abnormal_hearing_physiology0.97568847
111MP0002092_abnormal_eye_morphology0.97162914
112MP0000538_abnormal_urinary_bladder0.96743651
113MP0002733_abnormal_thermal_nociception0.95137400
114MP0002132_abnormal_respiratory_system0.94947046
115MP0002572_abnormal_emotion/affect_behav0.94043692
116MP0000678_abnormal_parathyroid_gland0.93540170
117MP0003698_abnormal_male_reproductive0.93316074
118MP0000569_abnormal_digit_pigmentation0.92659763
119MP0000026_abnormal_inner_ear0.91396626
120MP0003935_abnormal_craniofacial_develop0.91369762
121MP0002009_preneoplasia0.90840682
122MP0001970_abnormal_pain_threshold0.90476630
123MP0005220_abnormal_exocrine_pancreas0.90452112
124MP0004130_abnormal_muscle_cell0.90202010
125MP0002752_abnormal_somatic_nervous0.89277721
126MP0002751_abnormal_autonomic_nervous0.89199980
127MP0004233_abnormal_muscle_weight0.89089536
128MP0002184_abnormal_innervation0.88805135
129MP0000685_abnormal_immune_system0.88643614
130MP0008875_abnormal_xenobiotic_pharmacok0.87538146
131MP0000477_abnormal_intestine_morphology0.87027099
132MP0001849_ear_inflammation0.86956352
133MP0002114_abnormal_axial_skeleton0.86492654
134MP0002282_abnormal_trachea_morphology0.86238853
135MP0000653_abnormal_sex_gland0.85291438
136MP0002064_seizures0.85048376
137MP0005171_absent_coat_pigmentation0.84976266
138MP0002095_abnormal_skin_pigmentation0.84079920
139MP0004742_abnormal_vestibular_system0.83124297
140MP0005379_endocrine/exocrine_gland_phen0.82919912
141MP0001664_abnormal_digestion0.82618109
142MP0000432_abnormal_head_morphology0.82434322
143MP0003121_genomic_imprinting0.82151118
144MP0003880_abnormal_central_pattern0.82020942
145MP0001929_abnormal_gametogenesis0.81074428
146MP0002405_respiratory_system_inflammati0.80905233
147MP0002075_abnormal_coat/hair_pigmentati0.80728036
148MP0000371_diluted_coat_color0.79294735
149MP0000428_abnormal_craniofacial_morphol0.78194625
150MP0001145_abnormal_male_reproductive0.77881072
151MP0002429_abnormal_blood_cell0.77788021
152MP0001324_abnormal_eye_pigmentation0.77459182
153MP0005377_hearing/vestibular/ear_phenot0.77084156
154MP0003878_abnormal_ear_physiology0.77084156
155MP0005394_taste/olfaction_phenotype0.76816943
156MP0005499_abnormal_olfactory_system0.76816943
157MP0004924_abnormal_behavior0.76675149
158MP0005386_behavior/neurological_phenoty0.76675149
159MP0000230_abnormal_systemic_arterial0.76510777
160MP0002277_abnormal_respiratory_mucosa0.76209143
161MP0009250_abnormal_appendicular_skeleto0.75455285
162MP0005023_abnormal_wound_healing0.75168918
163MP0002116_abnormal_craniofacial_bone0.74619890
164MP0003453_abnormal_keratinocyte_physiol0.74131526
165MP0005410_abnormal_fertilization0.73608442
166MP0002970_abnormal_white_adipose0.71486827
167MP0003755_abnormal_palate_morphology0.71148544
168MP0002210_abnormal_sex_determination0.71020506
169MP0001915_intracranial_hemorrhage0.70932020
170MP0008770_decreased_survivor_rate0.69825189
171MP0001286_abnormal_eye_development0.69369175
172MP0005266_abnormal_metabolism0.68382507
173MP0009703_decreased_birth_body0.67126935
174MP0003938_abnormal_ear_development0.66026795
175MP0002925_abnormal_cardiovascular_devel0.66026148
176MP0000470_abnormal_stomach_morphology0.64690787
177MP0000716_abnormal_immune_system0.64283216
178MP0002697_abnormal_eye_size0.63768516
179MP0005501_abnormal_skin_physiology0.63572414
180MP0000537_abnormal_urethra_morphology0.62668605
181MP0008789_abnormal_olfactory_epithelium0.61862607

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.61154547
2Pancreatic cysts (HP:0001737)4.29841389
3Type II lissencephaly (HP:0007260)3.86161069
4Ependymoma (HP:0002888)3.84466637
5Pancreatic fibrosis (HP:0100732)3.70962492
6Congenital stationary night blindness (HP:0007642)3.66554725
7True hermaphroditism (HP:0010459)3.53106861
8Selective tooth agenesis (HP:0001592)3.43964899
9Nephronophthisis (HP:0000090)3.43214600
10Pendular nystagmus (HP:0012043)3.41130744
11Rectal fistula (HP:0100590)3.41060365
12Rectovaginal fistula (HP:0000143)3.41060365
13Hypochromic microcytic anemia (HP:0004840)3.40099187
14Attenuation of retinal blood vessels (HP:0007843)3.38793669
15Cerebellar dysplasia (HP:0007033)3.35328146
16Intestinal fistula (HP:0100819)3.32016628
17Molar tooth sign on MRI (HP:0002419)3.24850769
18Abnormality of midbrain morphology (HP:0002418)3.24850769
19Poikiloderma (HP:0001029)3.15962895
20Reticulocytopenia (HP:0001896)3.11369892
21Facial hemangioma (HP:0000329)3.09856852
22Abnormality of the renal cortex (HP:0011035)3.08167078
23Vaginal fistula (HP:0004320)3.02901373
24Absent thumb (HP:0009777)3.00932165
25Rhabdomyosarcoma (HP:0002859)2.99600440
26Astrocytoma (HP:0009592)2.98930839
27Abnormality of the astrocytes (HP:0100707)2.98930839
28Patellar aplasia (HP:0006443)2.97830076
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97355629
30Concave nail (HP:0001598)2.97025746
31Aplasia/hypoplasia of the humerus (HP:0006507)2.96911765
32Basal cell carcinoma (HP:0002671)2.94191785
33Abnormality of cells of the erythroid lineage (HP:0012130)2.90903030
34Abnormal number of incisors (HP:0011064)2.90552379
35Abnormality of the renal medulla (HP:0100957)2.87398178
36Short humerus (HP:0005792)2.84153015
37Neoplasm of striated muscle (HP:0009728)2.83655637
38Abnormal number of erythroid precursors (HP:0012131)2.83252097
39Chromsome breakage (HP:0040012)2.82782179
40Abnormality of the ileum (HP:0001549)2.82243235
41Cystic liver disease (HP:0006706)2.79947663
42Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.79874933
43Abolished electroretinogram (ERG) (HP:0000550)2.79623973
44Decreased central vision (HP:0007663)2.76923213
45Aplasia/Hypoplasia of the patella (HP:0006498)2.75689050
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.75663903
47Absent radius (HP:0003974)2.74628791
48Decreased circulating renin level (HP:0003351)2.73813070
49Annular pancreas (HP:0001734)2.72014295
50Tongue fasciculations (HP:0001308)2.69744636
51Tubular atrophy (HP:0000092)2.68753430
52Neoplasm of the oral cavity (HP:0100649)2.67693794
53Medulloblastoma (HP:0002885)2.67530818
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.63176994
55Absent forearm bone (HP:0003953)2.62822755
56Aplasia involving forearm bones (HP:0009822)2.62822755
57Volvulus (HP:0002580)2.58869008
58Chronic hepatic failure (HP:0100626)2.55915759
59Hypochromic anemia (HP:0001931)2.55827237
60Fibular aplasia (HP:0002990)2.53337490
61Genetic anticipation (HP:0003743)2.53138955
62Ulnar bowing (HP:0003031)2.52247303
63Squamous cell carcinoma (HP:0002860)2.51852612
64Pustule (HP:0200039)2.50132624
65Abnormal rod and cone electroretinograms (HP:0008323)2.49277579
66Myelodysplasia (HP:0002863)2.44197092
67Bony spicule pigmentary retinopathy (HP:0007737)2.43737583
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.42707064
69Short 5th finger (HP:0009237)2.42149303
70Renal cortical cysts (HP:0000803)2.42039734
71Hyperventilation (HP:0002883)2.40220466
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.38657891
73Asplenia (HP:0001746)2.38620925
74Increased corneal curvature (HP:0100692)2.38377520
75Keratoconus (HP:0000563)2.38377520
76Hypoplasia of the pons (HP:0012110)2.38102903
77Glioma (HP:0009733)2.38037981
78Muscle fibrillation (HP:0010546)2.36854978
79Birth length less than 3rd percentile (HP:0003561)2.36115764
80Meckel diverticulum (HP:0002245)2.35628583
81Multiple enchondromatosis (HP:0005701)2.35267937
82Colon cancer (HP:0003003)2.34692325
83Acute lymphatic leukemia (HP:0006721)2.34239752
84Broad alveolar ridges (HP:0000187)2.33524380
85Sclerocornea (HP:0000647)2.28596660
86Chorioretinal atrophy (HP:0000533)2.28530781
87Lissencephaly (HP:0001339)2.27667475
88Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.26999083
89Abnormality of the pons (HP:0007361)2.25199884
90Premature graying of hair (HP:0002216)2.23633822
91Abnormal drinking behavior (HP:0030082)2.22875612
92Polydipsia (HP:0001959)2.22875612
93Medial flaring of the eyebrow (HP:0010747)2.19755406
94Gaze-evoked nystagmus (HP:0000640)2.18952019
95Severe muscular hypotonia (HP:0006829)2.18862753
96Abnormal hemoglobin (HP:0011902)2.18671402
97Congenital sensorineural hearing impairment (HP:0008527)2.18194163
98Ectopic kidney (HP:0000086)2.17314333
99Bilateral microphthalmos (HP:0007633)2.17121508
100Progressive cerebellar ataxia (HP:0002073)2.16229507
101Impulsivity (HP:0100710)2.13809864
102Abnormality of alanine metabolism (HP:0010916)2.13269079
103Hyperalaninemia (HP:0003348)2.13269079
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13269079
105Partial agenesis of the corpus callosum (HP:0001338)2.13239239
106Fibular hypoplasia (HP:0003038)2.12237254
107Abnormality of the preputium (HP:0100587)2.08561152
108Aplastic anemia (HP:0001915)2.08542384
109Anencephaly (HP:0002323)2.08016665
110Intestinal atresia (HP:0011100)2.07863005
111Vertebral fusion (HP:0002948)2.07581685
112Breast hypoplasia (HP:0003187)2.07263170
113Trismus (HP:0000211)2.06944570
114Abnormality of the anterior horn cell (HP:0006802)2.05009161
115Degeneration of anterior horn cells (HP:0002398)2.05009161
116Missing ribs (HP:0000921)2.04924656
117Clumsiness (HP:0002312)2.04063068
118Furrowed tongue (HP:0000221)2.01538396
119Progressive inability to walk (HP:0002505)2.01226946
120Pallor (HP:0000980)2.01189549
121Abnormality of DNA repair (HP:0003254)2.00744376
122Orthostatic hypotension (HP:0001278)1.99709063
123Nephroblastoma (Wilms tumor) (HP:0002667)1.99482645
124Constricted visual fields (HP:0001133)1.98188067
125Abnormality of chromosome stability (HP:0003220)1.98158524
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.96644345
127Hypoplasia of the fovea (HP:0007750)1.96644345
128High anterior hairline (HP:0009890)1.95008136
129Abdominal situs inversus (HP:0003363)1.94395755
130Abnormality of abdominal situs (HP:0011620)1.94395755
131Increased IgM level (HP:0003496)1.92968375
132Methylmalonic aciduria (HP:0012120)1.92860548
133Male pseudohermaphroditism (HP:0000037)1.92508404
134Atresia of the external auditory canal (HP:0000413)1.92134764
135Aplasia/Hypoplasia of the tibia (HP:0005772)1.91796787
136Methylmalonic acidemia (HP:0002912)1.91580393
137Abnormality of the lower motor neuron (HP:0002366)1.91543978
138Congenital, generalized hypertrichosis (HP:0004540)1.91333123
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90497712
140Small hand (HP:0200055)1.90485556
141Abnormality of the nasal septum (HP:0000419)1.90243137
142Neoplasm of the adrenal cortex (HP:0100641)1.90188268
143Preauricular skin tag (HP:0000384)1.90180183
144Skin tags (HP:0010609)1.89877690
145Abnormality of the labia minora (HP:0012880)1.89861609
146Congenital hepatic fibrosis (HP:0002612)1.88562823
147Oral leukoplakia (HP:0002745)1.88500272
148Renal duplication (HP:0000075)1.87830914
149Abnormality of the renal collecting system (HP:0004742)1.87370776
150Prominent nose (HP:0000448)1.86964882
151Protruding tongue (HP:0010808)1.86903866
152Hemivertebrae (HP:0002937)1.86736290
153Small intestinal stenosis (HP:0012848)1.84164787
154Duodenal stenosis (HP:0100867)1.84164787
155Supernumerary spleens (HP:0009799)1.83405825
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.82458823
157Spinal muscular atrophy (HP:0007269)1.82441680
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.82270329
159Microretrognathia (HP:0000308)1.81784616
160Tracheoesophageal fistula (HP:0002575)1.81695622
161Hypotelorism (HP:0000601)1.81567148
162Inability to walk (HP:0002540)1.79125372
163Hypoplasia of the radius (HP:0002984)1.77711169
164Embryonal renal neoplasm (HP:0011794)1.77082232
165Cafe-au-lait spot (HP:0000957)1.76971296
166Premature ovarian failure (HP:0008209)1.76676072
167Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76470035
168Large for gestational age (HP:0001520)1.76361427
169Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76022630
170Vertebral hypoplasia (HP:0008417)1.76022630
171Proximal placement of thumb (HP:0009623)1.75686989
172Oligohydramnios (HP:0001562)1.75231558
173Shawl scrotum (HP:0000049)1.75212548
174Short thumb (HP:0009778)1.75042155
175Polyuria (HP:0000103)1.74294911
176Aplasia/hypoplasia of the uterus (HP:0008684)1.73402054
177Preaxial hand polydactyly (HP:0001177)1.72371561
178Enlarged kidneys (HP:0000105)1.72204527
179Hemiparesis (HP:0001269)1.71026350
180Abnormal biliary tract physiology (HP:0012439)1.69623968
181Bile duct proliferation (HP:0001408)1.69623968
182Dandy-Walker malformation (HP:0001305)1.68961320
183Pachygyria (HP:0001302)1.68383827
184Postaxial foot polydactyly (HP:0001830)1.68297200
185Hyperglycinuria (HP:0003108)1.65942779
1863-Methylglutaconic aciduria (HP:0003535)1.63351667
187Sloping forehead (HP:0000340)1.60433157
188Congenital primary aphakia (HP:0007707)1.59201282
189Gait imbalance (HP:0002141)1.58924989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.62072052
2CDK123.97566717
3ICK3.24748778
4ZAK3.14426736
5WNK42.90423838
6ADRBK22.83751080
7GRK12.67650834
8BMPR1B2.63852090
9CDC72.63171212
10CDK72.58897013
11MAP3K102.56944695
12NUAK12.51145267
13EEF2K2.49654086
14STK392.36240367
15TAOK32.35690873
16MAP3K62.31066624
17MATK2.22466780
18INSRR2.15158972
19WEE12.13154189
20MAP3K112.08863217
21NEK21.99939262
22MAPK151.98293445
23MAP4K21.96508560
24DDR21.92081882
25RPS6KB21.91559145
26WNK31.86831479
27TYRO31.71225683
28BUB11.70493300
29GRK61.69179517
30TAF11.69130030
31CASK1.64506721
32VRK21.62376901
33DYRK31.59854893
34PIM21.59833562
35TTK1.59023149
36PASK1.56808184
37STK101.56613609
38PLK11.54730917
39MAP4K11.52108931
40FLT31.47645472
41PIM11.46070261
42CHEK21.45073647
43OXSR11.44187477
44PRKD21.44102129
45MAPK131.41398431
46TRIB31.40563928
47TNIK1.37484786
48TLK11.36054091
49BMX1.35875173
50ATR1.34188044
51ERN11.30545745
52NME21.29962571
53CDK41.26124545
54TXK1.25899337
55PAK41.21289153
56SRPK11.20976029
57YES11.20013408
58DYRK1B1.19516537
59CDK61.18402866
60DAPK11.17181966
61CSK1.16496154
62PDGFRA1.15852007
63PKN21.14577157
64MAP3K41.13955027
65AURKB1.09887031
66CSF1R1.09881355
67CHEK11.08168798
68DYRK21.08088349
69FGFR21.04356121
70ADRBK11.04257833
71BCKDK1.02797225
72ACVR1B1.00424633
73UHMK10.96112461
74BRD40.94929034
75HIPK20.94624535
76DAPK20.93724352
77MTOR0.90783045
78TSSK60.89418781
79NEK10.88966226
80MUSK0.88160299
81STK110.88048328
82MAPK110.87277715
83FGR0.86617183
84* CDK20.86224280
85TESK20.86047251
86ALK0.85577933
87SIK20.85436360
88RPS6KC10.85321470
89RPS6KL10.85321470
90SCYL20.84914861
91MKNK10.84838398
92MAPKAPK30.84161323
93IKBKB0.84134008
94MAP3K80.81372141
95EPHA20.78647428
96BRSK20.77535905
97PRKCG0.77338825
98RPS6KA60.77252131
99LATS20.77209098
100TEC0.76801841
101RPS6KA50.76084941
102MAPKAPK50.75138386
103CDK80.74787801
104MAP2K20.71679650
105CSNK1A1L0.71557614
106TGFBR10.71071269
107ATM0.70811330
108PINK10.70527755
109CSNK1G10.69593032
110AURKA0.69077266
111CSNK1G30.68951245
112MAP3K90.68203404
113PRKCQ0.65955394
114NTRK30.64814532
115PAK30.64455427
116AKT30.63177383
117PRKG20.61862557
118AKT20.61683221
119ITK0.61409651
120CSNK1G20.61047634
121MKNK20.60278294
122BTK0.59894320
123MAP2K60.59418515
124PRKCE0.59030093
125PRKAA10.58938887
126STK40.57233545
127EIF2AK10.56955462
128RPS6KA40.56858780
129TGFBR20.56240939
130PHKG20.56041693
131PHKG10.56041693
132LRRK20.55424090
133VRK10.55006815
134STK30.54155231
135RPS6KA10.54118911
136PRKAA20.53577529
137MAP2K30.53407340
138TNK20.52203665
139CSNK2A20.51896917
140KIT0.51351784
141TIE10.50773851
142PRKCH0.50567224
143MAP2K10.50455821
144IRAK10.49627107
145CSNK2A10.49333135
146PAK20.49157897
147CDK10.48611290
148CSNK1A10.48531973
149TAOK20.47894027
150STK38L0.47296393
151ZAP700.46599549
152PIK3CA0.45153275
153CAMK10.44287425
154MELK0.44025908
155TRPM70.44012412
156STK160.43763526
157PKN10.43006847
158GSK3A0.42759394
159NME10.42144526
160PLK30.41183286
161CSNK1D0.40493770
162PLK40.39941087
163WNK10.39477010
164MARK30.39240699
165PRKACA0.39108786
166MAP2K70.38709708
167PAK10.37921485
168MAPK10.37893828
169PDK20.37506289
170MAPK140.37282810
171MARK20.36154237
172PRKCI0.35175168

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.84648884
2Mismatch repair_Homo sapiens_hsa034304.50851277
3Base excision repair_Homo sapiens_hsa034103.84664774
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48613441
5Spliceosome_Homo sapiens_hsa030403.25666268
6Ribosome_Homo sapiens_hsa030103.21027970
7RNA transport_Homo sapiens_hsa030132.84028679
8Phototransduction_Homo sapiens_hsa047442.80236813
9Homologous recombination_Homo sapiens_hsa034402.68584644
10Nucleotide excision repair_Homo sapiens_hsa034202.53472656
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.51607897
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44793421
13One carbon pool by folate_Homo sapiens_hsa006702.44343564
14Cell cycle_Homo sapiens_hsa041102.42842159
15Nicotine addiction_Homo sapiens_hsa050332.34404430
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.18850016
17Fanconi anemia pathway_Homo sapiens_hsa034602.18742657
18mRNA surveillance pathway_Homo sapiens_hsa030152.12583149
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05456470
20Linoleic acid metabolism_Homo sapiens_hsa005912.03851903
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91562317
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91489391
23RNA polymerase_Homo sapiens_hsa030201.91015205
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88102547
25Nitrogen metabolism_Homo sapiens_hsa009101.87093132
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79527612
27p53 signaling pathway_Homo sapiens_hsa041151.70420824
28Pyrimidine metabolism_Homo sapiens_hsa002401.68274611
29Tryptophan metabolism_Homo sapiens_hsa003801.66593405
30RNA degradation_Homo sapiens_hsa030181.60034769
31Morphine addiction_Homo sapiens_hsa050321.57475023
32Butanoate metabolism_Homo sapiens_hsa006501.53805660
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51932428
34Sulfur relay system_Homo sapiens_hsa041221.51185649
35Notch signaling pathway_Homo sapiens_hsa043301.46005139
36Taste transduction_Homo sapiens_hsa047421.43670370
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.41959587
38Ether lipid metabolism_Homo sapiens_hsa005651.39210497
39Olfactory transduction_Homo sapiens_hsa047401.38191838
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36931623
41Non-homologous end-joining_Homo sapiens_hsa034501.34423196
42ABC transporters_Homo sapiens_hsa020101.31481649
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29377954
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21923469
45Oxidative phosphorylation_Homo sapiens_hsa001901.20268792
46Basal transcription factors_Homo sapiens_hsa030221.18299740
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.16969874
48Glycerolipid metabolism_Homo sapiens_hsa005611.15517953
49Caffeine metabolism_Homo sapiens_hsa002321.13062060
50Primary immunodeficiency_Homo sapiens_hsa053401.12829661
51Fatty acid biosynthesis_Homo sapiens_hsa000611.10409291
52mTOR signaling pathway_Homo sapiens_hsa041501.09595039
53Thyroid cancer_Homo sapiens_hsa052161.08720638
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08678768
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06575841
56Folate biosynthesis_Homo sapiens_hsa007901.05487926
57Biosynthesis of amino acids_Homo sapiens_hsa012301.05334702
58Proteasome_Homo sapiens_hsa030501.04603454
59Herpes simplex infection_Homo sapiens_hsa051681.04160141
60Basal cell carcinoma_Homo sapiens_hsa052171.03963900
61Insulin secretion_Homo sapiens_hsa049111.02559514
62Acute myeloid leukemia_Homo sapiens_hsa052211.00092101
63Serotonergic synapse_Homo sapiens_hsa047260.99557113
64MicroRNAs in cancer_Homo sapiens_hsa052060.96585372
65Circadian entrainment_Homo sapiens_hsa047130.96355472
66Viral carcinogenesis_Homo sapiens_hsa052030.94975775
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94526960
68Hippo signaling pathway_Homo sapiens_hsa043900.94125414
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93346918
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93273974
71Protein export_Homo sapiens_hsa030600.91692488
72Chemical carcinogenesis_Homo sapiens_hsa052040.90980553
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90362652
74GABAergic synapse_Homo sapiens_hsa047270.89504664
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89367169
76Ovarian steroidogenesis_Homo sapiens_hsa049130.89095104
77Retinol metabolism_Homo sapiens_hsa008300.88966424
78Selenocompound metabolism_Homo sapiens_hsa004500.87067580
79Parkinsons disease_Homo sapiens_hsa050120.86672181
80Hedgehog signaling pathway_Homo sapiens_hsa043400.86524447
81Fructose and mannose metabolism_Homo sapiens_hsa000510.86433374
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85390425
83Bladder cancer_Homo sapiens_hsa052190.85272891
84Lysine degradation_Homo sapiens_hsa003100.84302129
85Colorectal cancer_Homo sapiens_hsa052100.83222643
86Epstein-Barr virus infection_Homo sapiens_hsa051690.82727673
87Chronic myeloid leukemia_Homo sapiens_hsa052200.81966073
88Glutamatergic synapse_Homo sapiens_hsa047240.80473365
89HTLV-I infection_Homo sapiens_hsa051660.80269225
90Salivary secretion_Homo sapiens_hsa049700.79854449
91Small cell lung cancer_Homo sapiens_hsa052220.79582312
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.78081322
93Huntingtons disease_Homo sapiens_hsa050160.77264294
94Calcium signaling pathway_Homo sapiens_hsa040200.74952302
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.74765088
96Arachidonic acid metabolism_Homo sapiens_hsa005900.74190747
97Systemic lupus erythematosus_Homo sapiens_hsa053220.73915651
98Propanoate metabolism_Homo sapiens_hsa006400.69688136
99Vitamin digestion and absorption_Homo sapiens_hsa049770.69073534
100Galactose metabolism_Homo sapiens_hsa000520.68034271
101Adherens junction_Homo sapiens_hsa045200.67173622
102TGF-beta signaling pathway_Homo sapiens_hsa043500.66456104
103Sulfur metabolism_Homo sapiens_hsa009200.66371717
104Antigen processing and presentation_Homo sapiens_hsa046120.64168281
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.63351205
106Fat digestion and absorption_Homo sapiens_hsa049750.61327321
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60066067
108Purine metabolism_Homo sapiens_hsa002300.58749097
109Pentose phosphate pathway_Homo sapiens_hsa000300.58608672
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57192242
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57177285
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56462027
113Oocyte meiosis_Homo sapiens_hsa041140.56288627
114Vitamin B6 metabolism_Homo sapiens_hsa007500.55520447
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55476594
116Legionellosis_Homo sapiens_hsa051340.55423881
117Wnt signaling pathway_Homo sapiens_hsa043100.54984581
118Alcoholism_Homo sapiens_hsa050340.54869962
119Cholinergic synapse_Homo sapiens_hsa047250.54795609
120Shigellosis_Homo sapiens_hsa051310.54273351
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.54112428
122Metabolic pathways_Homo sapiens_hsa011000.53161318
123Long-term depression_Homo sapiens_hsa047300.52267758
124Peroxisome_Homo sapiens_hsa041460.52163729
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51753944
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51397909
127Melanoma_Homo sapiens_hsa052180.49806828
128Apoptosis_Homo sapiens_hsa042100.49113655
129Asthma_Homo sapiens_hsa053100.48722677
130Arginine and proline metabolism_Homo sapiens_hsa003300.48013699
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.47949927
132Hepatitis B_Homo sapiens_hsa051610.47332554
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.46407625
134Alzheimers disease_Homo sapiens_hsa050100.46251527
135B cell receptor signaling pathway_Homo sapiens_hsa046620.46096366
136Non-small cell lung cancer_Homo sapiens_hsa052230.46028059
137Measles_Homo sapiens_hsa051620.45747645
138Pathways in cancer_Homo sapiens_hsa052000.44194347
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43092869
140Cardiac muscle contraction_Homo sapiens_hsa042600.42797318
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42444271
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41856387
143VEGF signaling pathway_Homo sapiens_hsa043700.41422349
144beta-Alanine metabolism_Homo sapiens_hsa004100.39897544
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38509735
146Regulation of autophagy_Homo sapiens_hsa041400.38112824
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38099426
148Cocaine addiction_Homo sapiens_hsa050300.38070568
149Endometrial cancer_Homo sapiens_hsa052130.38004179
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37962615
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.37478464
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37367891
153Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35906524
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33962501
155Pancreatic cancer_Homo sapiens_hsa052120.33801799
156N-Glycan biosynthesis_Homo sapiens_hsa005100.33299326
157Viral myocarditis_Homo sapiens_hsa054160.33196947
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30561466
159Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28735759
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27601891
161Prostate cancer_Homo sapiens_hsa052150.27548014
162Glycosaminoglycan degradation_Homo sapiens_hsa005310.26452144
163NF-kappa B signaling pathway_Homo sapiens_hsa040640.25336021
164AMPK signaling pathway_Homo sapiens_hsa041520.25273210
165Jak-STAT signaling pathway_Homo sapiens_hsa046300.24145242
166HIF-1 signaling pathway_Homo sapiens_hsa040660.22137973
167PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21563305
168Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21017853
169Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.20687816
170* Proteoglycans in cancer_Homo sapiens_hsa052050.16035083
171Hematopoietic cell lineage_Homo sapiens_hsa046400.16000456

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »