TFB1M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.33811380
2DNA deamination (GO:0045006)5.11425715
3ribosomal small subunit assembly (GO:0000028)4.88812572
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63949693
5ATP synthesis coupled proton transport (GO:0015986)4.63949693
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.63602706
7chaperone-mediated protein transport (GO:0072321)4.63551148
8DNA strand elongation involved in DNA replication (GO:0006271)4.48130027
9DNA strand elongation (GO:0022616)4.35853601
10telomere maintenance via semi-conservative replication (GO:0032201)4.34332167
11folic acid-containing compound biosynthetic process (GO:0009396)4.24979095
12nucleobase biosynthetic process (GO:0046112)4.10249105
13formation of translation preinitiation complex (GO:0001731)4.06463347
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03484321
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.03484321
16NADH dehydrogenase complex assembly (GO:0010257)4.03484321
17DNA replication initiation (GO:0006270)4.02816937
18telomere maintenance via recombination (GO:0000722)3.98521354
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.98013048
20protein complex biogenesis (GO:0070271)3.94860237
21mitochondrial respiratory chain complex assembly (GO:0033108)3.93937363
22maturation of SSU-rRNA (GO:0030490)3.84584243
23purine nucleobase biosynthetic process (GO:0009113)3.79898520
24protein neddylation (GO:0045116)3.77004565
25viral transcription (GO:0019083)3.73074386
26respiratory electron transport chain (GO:0022904)3.70337246
27ribosomal large subunit biogenesis (GO:0042273)3.70191244
28mitotic recombination (GO:0006312)3.69354535
29CENP-A containing nucleosome assembly (GO:0034080)3.69253212
30translational termination (GO:0006415)3.68770802
31electron transport chain (GO:0022900)3.63565396
32chromatin remodeling at centromere (GO:0031055)3.60724503
33proteasome assembly (GO:0043248)3.59820454
34respiratory chain complex IV assembly (GO:0008535)3.55802593
35translational elongation (GO:0006414)3.53224425
36pteridine-containing compound biosynthetic process (GO:0042559)3.52764278
37DNA unwinding involved in DNA replication (GO:0006268)3.50965334
38telomere maintenance via telomere lengthening (GO:0010833)3.48209856
39IMP biosynthetic process (GO:0006188)3.48093831
40spliceosomal snRNP assembly (GO:0000387)3.46808717
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44524654
42water-soluble vitamin biosynthetic process (GO:0042364)3.42100161
43kinetochore organization (GO:0051383)3.40189321
44ribonucleoprotein complex biogenesis (GO:0022613)3.36585778
45cotranslational protein targeting to membrane (GO:0006613)3.35582826
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35359577
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35359577
48regulation of mitotic spindle checkpoint (GO:1903504)3.32614354
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32614354
50protein targeting to ER (GO:0045047)3.32187261
51folic acid metabolic process (GO:0046655)3.31628772
52ribosome biogenesis (GO:0042254)3.29329565
53DNA double-strand break processing (GO:0000729)3.29322805
54translational initiation (GO:0006413)3.29050401
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24303900
56mitotic metaphase plate congression (GO:0007080)3.24226371
57ribosomal small subunit biogenesis (GO:0042274)3.23966763
58DNA replication checkpoint (GO:0000076)3.22803346
59replication fork processing (GO:0031297)3.22630049
60IMP metabolic process (GO:0046040)3.22180667
61cytochrome complex assembly (GO:0017004)3.21983285
62kinetochore assembly (GO:0051382)3.21894567
63histone exchange (GO:0043486)3.20151450
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.19633192
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19633192
66DNA replication-independent nucleosome organization (GO:0034724)3.19334341
67DNA replication-independent nucleosome assembly (GO:0006336)3.19334341
68pseudouridine synthesis (GO:0001522)3.18871919
69protein localization to endoplasmic reticulum (GO:0070972)3.18673649
70negative regulation of DNA-dependent DNA replication (GO:2000104)3.18583262
71establishment of protein localization to endoplasmic reticulum (GO:0072599)3.12068786
72DNA catabolic process, exonucleolytic (GO:0000738)3.11559498
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08408060
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08207440
75protein targeting to mitochondrion (GO:0006626)3.08049438
76regulation of mitochondrial translation (GO:0070129)3.07847445
77mitochondrial RNA metabolic process (GO:0000959)3.07256091
78* rRNA processing (GO:0006364)3.05532393
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05495798
80DNA replication-dependent nucleosome assembly (GO:0006335)3.05452372
81DNA replication-dependent nucleosome organization (GO:0034723)3.05452372
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04871192
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03973366
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.03421271
85DNA damage response, detection of DNA damage (GO:0042769)3.03343455
86protein-cofactor linkage (GO:0018065)3.01911521
87translation (GO:0006412)3.01573555
88peptidyl-histidine modification (GO:0018202)3.00823893
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99499964
90pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.97699164
91RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92889469
92histone mRNA metabolic process (GO:0008334)2.92141190
93* rRNA metabolic process (GO:0016072)2.91609589
94inner mitochondrial membrane organization (GO:0007007)2.90804968
95protein localization to kinetochore (GO:0034501)2.89355094
96transcription from mitochondrial promoter (GO:0006390)2.87851246
97viral life cycle (GO:0019058)2.87171143
98regulation of helicase activity (GO:0051095)2.85990391
99establishment of protein localization to mitochondrion (GO:0072655)2.85904163
100protein localization to mitochondrion (GO:0070585)2.85757585
101cellular component biogenesis (GO:0044085)2.85250383
102oxidative phosphorylation (GO:0006119)2.84400994
103cellular protein complex disassembly (GO:0043624)2.84023387
104transcription-coupled nucleotide-excision repair (GO:0006283)2.83911470
105protein localization to chromosome, centromeric region (GO:0071459)2.83717631
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83643807
107tetrahydrofolate metabolic process (GO:0046653)2.82227279
108mitotic nuclear envelope disassembly (GO:0007077)2.81272043
109tRNA processing (GO:0008033)2.80846699
110protein deneddylation (GO:0000338)2.80436940
111establishment of integrated proviral latency (GO:0075713)2.80225858
112amino acid salvage (GO:0043102)2.79761247
113L-methionine salvage (GO:0071267)2.79761247
114L-methionine biosynthetic process (GO:0071265)2.79761247
115telomere organization (GO:0032200)2.79519582
116telomere maintenance (GO:0000723)2.78020684
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77559328
118maturation of 5.8S rRNA (GO:0000460)2.77417945
119metaphase plate congression (GO:0051310)2.76186100
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75205340
121negative regulation of ligase activity (GO:0051352)2.75205340
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74971940
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74893364
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74893364
125termination of RNA polymerase III transcription (GO:0006386)2.74433927
126transcription elongation from RNA polymerase III promoter (GO:0006385)2.74433927
127pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.73603155
128ribosome assembly (GO:0042255)2.73575605
1292-deoxyribonucleotide biosynthetic process (GO:0009265)2.71516414
130deoxyribose phosphate biosynthetic process (GO:0046385)2.71516414
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.70791695
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.70791695
133signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.70791695
134meiotic chromosome segregation (GO:0045132)2.70756881
135nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69240772
136spliceosomal complex assembly (GO:0000245)2.69117116
137regulation of cellular amino acid metabolic process (GO:0006521)2.68159551
138mitotic chromosome condensation (GO:0007076)2.66933171
139cullin deneddylation (GO:0010388)2.66061232
140signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65753887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.12565285
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.15174591
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89574746
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56002365
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.28919476
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14739713
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.11508464
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.97165872
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94276440
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93776748
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82009691
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71012132
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67017007
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63386525
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56255579
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55199010
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49828992
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.41924254
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38948433
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33384827
21VDR_23849224_ChIP-Seq_CD4+_Human2.29404698
22XRN2_22483619_ChIP-Seq_HELA_Human2.23178958
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19868139
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19228265
25DCP1A_22483619_ChIP-Seq_HELA_Human2.14048335
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09007661
27ZNF274_21170338_ChIP-Seq_K562_Hela2.06878419
28FOXP3_21729870_ChIP-Seq_TREG_Human2.06699265
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03536438
30* GABP_19822575_ChIP-Seq_HepG2_Human2.02403770
31* SRF_21415370_ChIP-Seq_HL-1_Mouse1.99159330
32AR_21909140_ChIP-Seq_LNCAP_Human1.98972644
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92728486
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89296324
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84932264
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80361269
37EWS_26573619_Chip-Seq_HEK293_Human1.78800867
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77058480
39TTF2_22483619_ChIP-Seq_HELA_Human1.72322786
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71821987
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71597252
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70838501
43VDR_22108803_ChIP-Seq_LS180_Human1.70805196
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.69338752
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.68703936
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.64950902
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63898661
48* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63865265
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63284334
50FUS_26573619_Chip-Seq_HEK293_Human1.59792522
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58780162
52* ELK1_19687146_ChIP-ChIP_HELA_Human1.55701288
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52972256
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52380211
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51611790
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51249761
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51021396
58IGF1R_20145208_ChIP-Seq_DFB_Human1.48039828
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.47716281
60CIITA_25753668_ChIP-Seq_RAJI_Human1.44565558
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44259424
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43502939
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39255174
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39030086
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36697773
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.31737115
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30660263
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29442018
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28199845
70KDM5A_27292631_Chip-Seq_BREAST_Human1.26597059
71* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21854873
72* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21302380
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21160439
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20842626
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20704763
76IRF1_19129219_ChIP-ChIP_H3396_Human1.19792016
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17599200
78MYC_22102868_ChIP-Seq_BL_Human1.15809968
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.14248220
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14122347
81MYC_18940864_ChIP-ChIP_HL60_Human1.14081694
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13804355
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13070321
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12709918
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12455437
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11844335
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11470412
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10942474
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10901237
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.07624186
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05297654
92TAF15_26573619_Chip-Seq_HEK293_Human1.04103173
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02320906
94TFEB_21752829_ChIP-Seq_HELA_Human1.01806323
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99917452
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99479711
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99168256
98P300_19829295_ChIP-Seq_ESCs_Human0.98958070
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98054626
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97955731
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97549691
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96470683
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95533220
104EGR1_19374776_ChIP-ChIP_THP-1_Human0.94163781
105TP53_22573176_ChIP-Seq_HFKS_Human0.93704753
106SPI1_23547873_ChIP-Seq_NB4_Human0.92923996
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92662444
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91477776
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88956969
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88180478
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87109768
112ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85876403
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.83975391
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83960968
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83402629
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83122234
117PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82419946
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82391061
119NANOG_19829295_ChIP-Seq_ESCs_Human0.81865430
120SOX2_19829295_ChIP-Seq_ESCs_Human0.81865430
121SCL_19346495_ChIP-Seq_HPC-7_Human0.80311525
122IRF8_22096565_ChIP-ChIP_GC-B_Human0.78914398
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.78019762
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77655550
125VDR_21846776_ChIP-Seq_THP-1_Human0.77178418
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77092025
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77012246
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.76799752
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76523370
130RXR_22158963_ChIP-Seq_LIVER_Mouse0.75162086
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74513241
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.74383810
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74346073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.58499745
2MP0003806_abnormal_nucleotide_metabolis4.14783877
3MP0010094_abnormal_chromosome_stability4.00611016
4MP0004957_abnormal_blastocyst_morpholog3.91713018
5MP0003111_abnormal_nucleus_morphology3.37580850
6MP0003077_abnormal_cell_cycle3.23711650
7MP0008057_abnormal_DNA_replication3.19407030
8MP0008058_abnormal_DNA_repair3.12846649
9MP0004147_increased_porphyrin_level2.99871731
10MP0002139_abnormal_hepatobiliary_system2.49070929
11MP0003656_abnormal_erythrocyte_physiolo2.41902687
12MP0003186_abnormal_redox_activity2.33369779
13MP0002396_abnormal_hematopoietic_system2.24862429
14MP0003195_calcinosis2.21323586
15MP0002938_white_spotting2.18905165
16MP0009697_abnormal_copulation2.16953529
17MP0008007_abnormal_cellular_replicative2.16329563
18MP0005365_abnormal_bile_salt2.15443730
19MP0008877_abnormal_DNA_methylation2.11852742
20MP0005085_abnormal_gallbladder_physiolo2.08168115
21MP0003136_yellow_coat_color2.02621255
22* MP0006036_abnormal_mitochondrial_physio1.98967010
23MP0008932_abnormal_embryonic_tissue1.97696889
24MP0000372_irregular_coat_pigmentation1.95364069
25MP0006072_abnormal_retinal_apoptosis1.91501848
26MP0001529_abnormal_vocalization1.83764116
27MP0003123_paternal_imprinting1.81366634
28MP0001730_embryonic_growth_arrest1.75584081
29MP0003786_premature_aging1.73417174
30MP0005360_urolithiasis1.72705220
31MP0008875_abnormal_xenobiotic_pharmacok1.67919257
32MP0002102_abnormal_ear_morphology1.66896563
33MP0003718_maternal_effect1.66445789
34MP0001764_abnormal_homeostasis1.66048593
35MP0002163_abnormal_gland_morphology1.63223316
36MP0008789_abnormal_olfactory_epithelium1.62700112
37MP0003941_abnormal_skin_development1.60970105
38MP0005397_hematopoietic_system_phenotyp1.60297183
39MP0001545_abnormal_hematopoietic_system1.60297183
40MP0000490_abnormal_crypts_of1.56770963
41MP0003122_maternal_imprinting1.54624316
42MP0003121_genomic_imprinting1.50237172
43MP0000350_abnormal_cell_proliferation1.37517710
44MP0003763_abnormal_thymus_physiology1.35283672
45MP0006035_abnormal_mitochondrial_morpho1.35100522
46MP0002019_abnormal_tumor_incidence1.31732441
47MP0006292_abnormal_olfactory_placode1.30943081
48MP0008995_early_reproductive_senescence1.27549250
49MP0004133_heterotaxia1.26832687
50MP0001929_abnormal_gametogenesis1.26242448
51MP0005551_abnormal_eye_electrophysiolog1.25372483
52MP0000313_abnormal_cell_death1.23957869
53MP0002210_abnormal_sex_determination1.23560420
54MP0002736_abnormal_nociception_after1.21708583
55MP0004808_abnormal_hematopoietic_stem1.19284977
56MP0009333_abnormal_splenocyte_physiolog1.18338408
57MP0001984_abnormal_olfaction1.18002901
58* MP0002080_prenatal_lethality1.17288816
59MP0005075_abnormal_melanosome_morpholog1.15450740
60MP0005253_abnormal_eye_physiology1.14152408
61MP0002132_abnormal_respiratory_system1.14032159
62MP0001145_abnormal_male_reproductive1.13202624
63MP0005389_reproductive_system_phenotype1.11522831
64* MP0001697_abnormal_embryo_size1.11329832
65MP0004142_abnormal_muscle_tone1.11255284
66MP0005394_taste/olfaction_phenotype1.09115787
67MP0005499_abnormal_olfactory_system1.09115787
68MP0008872_abnormal_physiological_respon1.08525087
69MP0000653_abnormal_sex_gland1.07451290
70MP0005319_abnormal_enzyme/_coenzyme1.07019105
71MP0005380_embryogenesis_phenotype1.06675581
72MP0001672_abnormal_embryogenesis/_devel1.06675581
73MP0003567_abnormal_fetal_cardiomyocyte1.06087383
74MP0000689_abnormal_spleen_morphology1.06086877
75MP0005083_abnormal_biliary_tract1.05808155
76MP0002398_abnormal_bone_marrow1.04462917
77MP0005379_endocrine/exocrine_gland_phen1.03887489
78MP0002638_abnormal_pupillary_reflex1.03223632
79MP0003937_abnormal_limbs/digits/tail_de1.02346403
80MP0005408_hypopigmentation1.00890967
81* MP0001286_abnormal_eye_development1.00417295
82MP0003984_embryonic_growth_retardation1.00192349
83MP0005645_abnormal_hypothalamus_physiol0.97767601
84MP0000598_abnormal_liver_morphology0.96984503
85MP0001485_abnormal_pinna_reflex0.96004470
86MP0002088_abnormal_embryonic_growth/wei0.95595336
87MP0000358_abnormal_cell_content/0.95584984
88MP0003880_abnormal_central_pattern0.94959902
89MP0000631_abnormal_neuroendocrine_gland0.91960813
90MP0002837_dystrophic_cardiac_calcinosis0.91934829
91MP0002722_abnormal_immune_system0.91863813
92MP0002233_abnormal_nose_morphology0.91369797
93MP0003119_abnormal_digestive_system0.91148128
94MP0002429_abnormal_blood_cell0.90639522
95MP0002751_abnormal_autonomic_nervous0.90544778
96MP0002269_muscular_atrophy0.90454168
97MP0004145_abnormal_muscle_electrophysio0.89786200
98MP0005266_abnormal_metabolism0.89682974
99MP0005395_other_phenotype0.89177402
100MP0000609_abnormal_liver_physiology0.88847565
101MP0003011_delayed_dark_adaptation0.88783022
102MP0005332_abnormal_amino_acid0.88326899
103MP0003646_muscle_fatigue0.88226275
104MP0010352_gastrointestinal_tract_polyps0.87389888
105MP0001119_abnormal_female_reproductive0.86655161
106MP0001968_abnormal_touch/_nociception0.86359576
107MP0003787_abnormal_imprinting0.85927896
108MP0006054_spinal_hemorrhage0.85351483
109MP0000569_abnormal_digit_pigmentation0.84877481
110MP0003890_abnormal_embryonic-extraembry0.84617518
111MP0002090_abnormal_vision0.84529469
112MP0002928_abnormal_bile_duct0.82910065
113MP0001324_abnormal_eye_pigmentation0.82608032
114MP0005084_abnormal_gallbladder_morpholo0.82513906
115MP0002095_abnormal_skin_pigmentation0.82311568
116MP0002234_abnormal_pharynx_morphology0.81534116
117MP0003221_abnormal_cardiomyocyte_apopto0.80838828
118MP0001666_abnormal_nutrient_absorption0.80070014
119MP0005636_abnormal_mineral_homeostasis0.78478731
120MP0004264_abnormal_extraembryonic_tissu0.78173294
121MP0002086_abnormal_extraembryonic_tissu0.78118972
122MP0010329_abnormal_lipoprotein_level0.76785364
123MP0001835_abnormal_antigen_presentation0.76520359
124MP0000049_abnormal_middle_ear0.76413514
125MP0000749_muscle_degeneration0.76311863
126MP0000685_abnormal_immune_system0.75900037
127MP0000703_abnormal_thymus_morphology0.75495966
128MP0004197_abnormal_fetal_growth/weight/0.74511546
129* MP0002085_abnormal_embryonic_tissue0.74501253
130MP0005220_abnormal_exocrine_pancreas0.74449126
131MP0002160_abnormal_reproductive_system0.73381074
132MP0002653_abnormal_ependyma_morphology0.72996797
133MP0001661_extended_life_span0.72879695
134MP0005174_abnormal_tail_pigmentation0.71983943
135MP0001293_anophthalmia0.71934548
136MP0002282_abnormal_trachea_morphology0.71805952
137MP0005391_vision/eye_phenotype0.71614618
138MP0005671_abnormal_response_to0.71506501
139MP0002697_abnormal_eye_size0.71284175
140MP0000716_abnormal_immune_system0.71055664
141MP0005058_abnormal_lysosome_morphology0.70735302
142MP0002084_abnormal_developmental_patter0.70588737
143MP0008469_abnormal_protein_level0.70520919
144MP0001346_abnormal_lacrimal_gland0.70512596
145MP0005410_abnormal_fertilization0.70144918
146MP0003943_abnormal_hepatobiliary_system0.70105923
147MP0009643_abnormal_urine_homeostasis0.69000820
148MP0009379_abnormal_foot_pigmentation0.68755091
149MP0001873_stomach_inflammation0.68711374
150MP0005376_homeostasis/metabolism_phenot0.68651837
151MP0003698_abnormal_male_reproductive0.68309202

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.37319025
2Abnormal number of erythroid precursors (HP:0012131)4.35297825
3Birth length less than 3rd percentile (HP:0003561)4.33990026
4Abnormality of the heme biosynthetic pathway (HP:0010472)4.27532716
5Reticulocytopenia (HP:0001896)4.17188467
6Aplastic anemia (HP:0001915)4.12273256
7Hepatic necrosis (HP:0002605)3.47806634
8Oral leukoplakia (HP:0002745)3.46179654
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.38321495
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.38321495
11Hepatocellular necrosis (HP:0001404)3.34639973
12Abnormality of pyrimidine metabolism (HP:0004353)3.23903181
13Chromsome breakage (HP:0040012)3.08157098
14Increased serum lactate (HP:0002151)3.00004501
15Abnormality of the labia minora (HP:0012880)2.91748195
16Carpal bone hypoplasia (HP:0001498)2.90755185
17Hypobetalipoproteinemia (HP:0003563)2.89681620
18Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81867962
19Increased CSF lactate (HP:0002490)2.76704578
20Pallor (HP:0000980)2.75804436
21Renal Fanconi syndrome (HP:0001994)2.71775151
22Pancreatic fibrosis (HP:0100732)2.71522807
23Breast hypoplasia (HP:0003187)2.71136520
24Macrocytic anemia (HP:0001972)2.68377495
253-Methylglutaconic aciduria (HP:0003535)2.66753646
26Pancytopenia (HP:0001876)2.66435440
27Mitochondrial inheritance (HP:0001427)2.66282793
28Pancreatic cysts (HP:0001737)2.64798653
29Abnormal mitochondria in muscle tissue (HP:0008316)2.59452508
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58405919
31Microretrognathia (HP:0000308)2.56107899
32Acute necrotizing encephalopathy (HP:0006965)2.53238782
33Hyperglycinuria (HP:0003108)2.50851573
34Methylmalonic acidemia (HP:0002912)2.47462112
35Abnormality of midbrain morphology (HP:0002418)2.46572398
36Molar tooth sign on MRI (HP:0002419)2.46572398
37Acute encephalopathy (HP:0006846)2.45963152
38Generalized aminoaciduria (HP:0002909)2.44987894
39Type I transferrin isoform profile (HP:0003642)2.43742505
40Secondary amenorrhea (HP:0000869)2.42005992
41Degeneration of anterior horn cells (HP:0002398)2.39231293
42Abnormality of the anterior horn cell (HP:0006802)2.39231293
43True hermaphroditism (HP:0010459)2.37042719
44Lactic acidosis (HP:0003128)2.36291567
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35493168
46Irregular epiphyses (HP:0010582)2.34654275
47Abnormality of reticulocytes (HP:0004312)2.34478520
48Abnormality of glycolysis (HP:0004366)2.31203348
49Increased serum pyruvate (HP:0003542)2.31203348
50Supernumerary spleens (HP:0009799)2.30995365
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.30878484
52Respiratory failure (HP:0002878)2.29636359
53Cerebral edema (HP:0002181)2.28559258
54Nausea (HP:0002018)2.27999129
55Abnormality of chromosome stability (HP:0003220)2.27821848
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27273635
57Abnormality of alanine metabolism (HP:0010916)2.27273635
58Hyperalaninemia (HP:0003348)2.27273635
59Rough bone trabeculation (HP:0100670)2.26589841
60Lipid accumulation in hepatocytes (HP:0006561)2.25891899
61Absent thumb (HP:0009777)2.25888306
62Small intestinal stenosis (HP:0012848)2.24916019
63Duodenal stenosis (HP:0100867)2.24916019
64Cerebral hypomyelination (HP:0006808)2.23170556
65Abnormality of glycine metabolism (HP:0010895)2.21605762
66Abnormality of serine family amino acid metabolism (HP:0010894)2.21605762
67Triphalangeal thumb (HP:0001199)2.21122474
68Thrombocytosis (HP:0001894)2.18432495
69Hypoglycemic coma (HP:0001325)2.18016735
70Hypoplasia of the pons (HP:0012110)2.17318799
71Increased hepatocellular lipid droplets (HP:0006565)2.17068881
72Abnormality of the preputium (HP:0100587)2.16390778
73Bone marrow hypocellularity (HP:0005528)2.14318520
74Medulloblastoma (HP:0002885)2.14152094
75Meckel diverticulum (HP:0002245)2.13876835
76Optic disc pallor (HP:0000543)2.13281664
77Abnormality of the duodenum (HP:0002246)2.13221331
78Myelodysplasia (HP:0002863)2.12881439
79Abnormality of methionine metabolism (HP:0010901)2.11214907
80Abnormality of lateral ventricle (HP:0030047)2.11201729
81Hyperbilirubinemia (HP:0002904)2.09249333
82Colon cancer (HP:0003003)2.09179592
83CNS demyelination (HP:0007305)2.07260550
84IgM deficiency (HP:0002850)2.07024940
85Premature graying of hair (HP:0002216)2.06882168
86Increased intramyocellular lipid droplets (HP:0012240)2.06502107
87Abnormal protein N-linked glycosylation (HP:0012347)2.05949633
88Abnormal protein glycosylation (HP:0012346)2.05949633
89Abnormal glycosylation (HP:0012345)2.05949633
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05949633
91Nephronophthisis (HP:0000090)2.05620976
92Abnormal spermatogenesis (HP:0008669)2.04685421
93Leukodystrophy (HP:0002415)2.04526686
94Abnormal lung lobation (HP:0002101)2.04289780
95Lethargy (HP:0001254)2.04213615
96Multiple enchondromatosis (HP:0005701)2.04029569
97Abnormality of the pons (HP:0007361)2.03579865
98Bile duct proliferation (HP:0001408)2.03379990
99Abnormal biliary tract physiology (HP:0012439)2.03379990
100Methylmalonic aciduria (HP:0012120)2.03072740
101Intrahepatic cholestasis (HP:0001406)2.02901925
102Abnormality of fatty-acid metabolism (HP:0004359)2.02643836
103Renal cortical cysts (HP:0000803)2.02381934
104Type 2 muscle fiber atrophy (HP:0003554)2.01941044
105Abnormality of serum amino acid levels (HP:0003112)2.01725068
106Medial flaring of the eyebrow (HP:0010747)2.01217284
107Abnormality of the ileum (HP:0001549)2.01118609
108Hyperammonemia (HP:0001987)2.00878553
109Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00660857
110Hyperglycinemia (HP:0002154)2.00573697
111Glycosuria (HP:0003076)2.00468014
112Abnormality of urine glucose concentration (HP:0011016)2.00468014
113Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99959564
114Muscle fiber atrophy (HP:0100295)1.99744577
115Progressive macrocephaly (HP:0004481)1.96705164
11611 pairs of ribs (HP:0000878)1.96181647
117Increased muscle lipid content (HP:0009058)1.95462242
118Patellar aplasia (HP:0006443)1.90863171
119Exercise intolerance (HP:0003546)1.89103756
120Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88859867
121Dicarboxylic aciduria (HP:0003215)1.88859867
122Sloping forehead (HP:0000340)1.86358742
123Reduced antithrombin III activity (HP:0001976)1.86278394
124Septo-optic dysplasia (HP:0100842)1.85159508
125Poikilocytosis (HP:0004447)1.84862192
126Opisthotonus (HP:0002179)1.84734755
127Premature ovarian failure (HP:0008209)1.83313439
128Clubbing of toes (HP:0100760)1.82998103
129Microvesicular hepatic steatosis (HP:0001414)1.81029556
130Horseshoe kidney (HP:0000085)1.80982494
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.80638626
132Megaloblastic anemia (HP:0001889)1.79302331
133Exertional dyspnea (HP:0002875)1.78244313
134Sclerocornea (HP:0000647)1.77175014
135Aplasia/Hypoplasia of the patella (HP:0006498)1.76798660
136Abnormality of renal resorption (HP:0011038)1.76527525
137Respiratory difficulties (HP:0002880)1.76084023
138Intestinal atresia (HP:0011100)1.75541270
139Sparse eyelashes (HP:0000653)1.74838764
140Congenital, generalized hypertrichosis (HP:0004540)1.73723366
141Anencephaly (HP:0002323)1.70217266
142Bilateral microphthalmos (HP:0007633)1.69629401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.16746358
2BUB14.00353297
3WEE13.82883729
4EIF2AK13.41468889
5STK163.39812947
6NUAK13.30055101
7MST43.11913980
8ACVR1B3.03545467
9NME22.99178732
10BCKDK2.92765103
11CDC72.68149292
12NEK22.51532470
13VRK12.30179789
14BMPR1B2.21567965
15SRPK12.20456836
16PASK2.13998118
17DYRK32.13155712
18BRSK22.12081837
19WNK32.09039044
20NEK12.04016032
21FLT32.00622292
22TAF11.90840771
23EIF2AK31.89688133
24FRK1.82281352
25PLK11.80314629
26NME11.77723560
27TSSK61.76359363
28TRIM281.76152767
29TNIK1.75814488
30TTK1.75552851
31MKNK11.65969367
32RPS6KA41.63173757
33RPS6KB21.62800934
34PLK41.59744128
35CDK41.57427222
36ATR1.57145466
37MAP4K21.51916064
38AURKB1.51794962
39CCNB11.38756828
40PNCK1.35118008
41TGFBR11.34397193
42PDK41.30797904
43PDK31.30797904
44PDK21.30559838
45BLK1.27698168
46AURKA1.25954658
47CDK71.25490114
48MKNK21.19677126
49BRSK11.18377280
50CHEK21.18081816
51DYRK21.09083526
52PLK31.02179082
53PLK21.01591080
54MAP3K81.01461312
55KIT1.00616334
56INSRR0.99802320
57OXSR10.97999449
58MUSK0.97454870
59MAPKAPK30.95196139
60KDR0.92883774
61WNK40.92699494
62SCYL20.92475596
63GRK10.91312877
64PIM20.91069466
65BCR0.87787906
66MAP4K10.87773613
67CDK80.87140792
68CHEK10.86701306
69TYK20.84730940
70STK390.83145964
71EEF2K0.79619591
72TLK10.75571239
73STK100.74272479
74CSNK2A10.72661876
75MAP3K110.71809103
76MAPK110.71766538
77PBK0.71630907
78CSNK2A20.71325967
79STK30.71320562
80PIM10.70954762
81ATM0.66980058
82STK40.65742382
83LRRK20.64122683
84PAK40.63429391
85CDK190.62548904
86TEC0.61914090
87BRAF0.61860053
88ZAP700.61819532
89CSNK1G10.60830574
90MAP3K100.59960521
91BTK0.59662903
92MAP3K120.59614255
93CDK60.57439718
94MAP3K40.56533086
95CSNK1E0.53929473
96PRKCG0.53649051
97MAPKAPK50.53037698
98CSNK1G30.52203141
99TIE10.51834091
100CDK30.51822336
101TESK20.51328620
102PKN20.51261912
103TXK0.50154053
104ADRBK20.49976850
105JAK30.49280794
106CDK20.48877715
107ERN10.48101549
108MAP2K30.47532074
109CSF1R0.46660523
110FGFR20.45467847
111PINK10.45384242
112ZAK0.45321107
113RPS6KA50.45282191
114ILK0.44912733
115MELK0.43292802
116MST1R0.43263238
117CSNK1G20.42377249
118TAOK20.40647843
119ERBB40.40478933
120LYN0.40139569
121CDK90.39338227
122NLK0.38221409
123FGFR10.37723844
124DAPK10.37366763
125ABL20.36846278
126CSNK1A1L0.36235029
127MAP3K60.36021948
128MAP2K60.35641632
129TESK10.35178630
130EIF2AK20.34844105
131MYLK0.33782193
132ALK0.33118902
133TAOK30.32896854
134IKBKB0.32551429
135FGFR40.31764556
136NEK90.31300471
137STK38L0.31170982
138CDK10.30266730
139OBSCN0.29063611
140CSNK1A10.26959438
141PRKCQ0.26479779
142STK240.26359208
143MINK10.25800738
144MAPK130.25668173
145PRKDC0.25596558
146PRKCE0.24076929

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46244279
2Mismatch repair_Homo sapiens_hsa034303.59099698
3Ribosome_Homo sapiens_hsa030103.47184180
4Proteasome_Homo sapiens_hsa030503.23447399
5RNA polymerase_Homo sapiens_hsa030202.78595988
6Homologous recombination_Homo sapiens_hsa034402.73114142
7Base excision repair_Homo sapiens_hsa034102.67704813
8One carbon pool by folate_Homo sapiens_hsa006702.62197230
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61355399
10Pyrimidine metabolism_Homo sapiens_hsa002402.49063395
11Spliceosome_Homo sapiens_hsa030402.39148889
12RNA transport_Homo sapiens_hsa030132.33351683
13Nucleotide excision repair_Homo sapiens_hsa034202.32783861
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09552071
15Cell cycle_Homo sapiens_hsa041101.88228801
16Protein export_Homo sapiens_hsa030601.85305443
17Non-homologous end-joining_Homo sapiens_hsa034501.83421511
18Folate biosynthesis_Homo sapiens_hsa007901.80410946
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74089366
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69847778
21RNA degradation_Homo sapiens_hsa030181.68079533
22Selenocompound metabolism_Homo sapiens_hsa004501.66790959
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.63638572
24Basal transcription factors_Homo sapiens_hsa030221.58057459
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55463677
26Fanconi anemia pathway_Homo sapiens_hsa034601.53545078
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49854973
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.49838387
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42745376
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34338946
31Biosynthesis of amino acids_Homo sapiens_hsa012301.34164708
32Purine metabolism_Homo sapiens_hsa002301.28151650
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23248204
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18770184
35Carbon metabolism_Homo sapiens_hsa012001.14669426
36Pyruvate metabolism_Homo sapiens_hsa006201.13276688
37Steroid biosynthesis_Homo sapiens_hsa001001.10697448
38Sulfur relay system_Homo sapiens_hsa041221.10212506
39Cardiac muscle contraction_Homo sapiens_hsa042601.09823418
40Parkinsons disease_Homo sapiens_hsa050121.06637064
41Vitamin B6 metabolism_Homo sapiens_hsa007501.06607319
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06164468
43Butanoate metabolism_Homo sapiens_hsa006501.06128352
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05924460
45Pentose phosphate pathway_Homo sapiens_hsa000301.04503345
46Propanoate metabolism_Homo sapiens_hsa006401.03498874
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.02172544
48Glutathione metabolism_Homo sapiens_hsa004800.99547977
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96395934
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95309955
51p53 signaling pathway_Homo sapiens_hsa041150.91097364
52Oxidative phosphorylation_Homo sapiens_hsa001900.89198785
53Huntingtons disease_Homo sapiens_hsa050160.86191719
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85841572
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85647221
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81483558
57Sulfur metabolism_Homo sapiens_hsa009200.80210334
58mRNA surveillance pathway_Homo sapiens_hsa030150.78436039
59Caffeine metabolism_Homo sapiens_hsa002320.78067377
60Peroxisome_Homo sapiens_hsa041460.73960786
61Nitrogen metabolism_Homo sapiens_hsa009100.73941968
62Fatty acid degradation_Homo sapiens_hsa000710.72725294
63Antigen processing and presentation_Homo sapiens_hsa046120.72090762
64Tryptophan metabolism_Homo sapiens_hsa003800.68216772
65Systemic lupus erythematosus_Homo sapiens_hsa053220.67122156
66Phototransduction_Homo sapiens_hsa047440.66393064
67Epstein-Barr virus infection_Homo sapiens_hsa051690.66264108
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65529688
69Metabolic pathways_Homo sapiens_hsa011000.64483634
70N-Glycan biosynthesis_Homo sapiens_hsa005100.64367898
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.61782223
72Vitamin digestion and absorption_Homo sapiens_hsa049770.59752330
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59646855
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58778045
75Chemical carcinogenesis_Homo sapiens_hsa052040.56108245
76Fructose and mannose metabolism_Homo sapiens_hsa000510.55524013
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54871049
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54852419
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53407234
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51023113
81Herpes simplex infection_Homo sapiens_hsa051680.50855042
82Galactose metabolism_Homo sapiens_hsa000520.50121069
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48106358
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.46987965
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46687467
86beta-Alanine metabolism_Homo sapiens_hsa004100.45903872
87Legionellosis_Homo sapiens_hsa051340.45002171
88Primary immunodeficiency_Homo sapiens_hsa053400.44997326
89Arginine and proline metabolism_Homo sapiens_hsa003300.44689343
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44092542
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38564313
92Arginine biosynthesis_Homo sapiens_hsa002200.38211279
93Regulation of autophagy_Homo sapiens_hsa041400.37786909
94Oocyte meiosis_Homo sapiens_hsa041140.37299259
95Olfactory transduction_Homo sapiens_hsa047400.37270905
96Other glycan degradation_Homo sapiens_hsa005110.35903212
97Alzheimers disease_Homo sapiens_hsa050100.35069775
98Fatty acid metabolism_Homo sapiens_hsa012120.33951707
99Viral carcinogenesis_Homo sapiens_hsa052030.32991501
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32750057
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32742859
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32129977
103Complement and coagulation cascades_Homo sapiens_hsa046100.31812278
104Ether lipid metabolism_Homo sapiens_hsa005650.29346859
105Starch and sucrose metabolism_Homo sapiens_hsa005000.28210856
106Fat digestion and absorption_Homo sapiens_hsa049750.27924477
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.25053894
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24762866
109Tyrosine metabolism_Homo sapiens_hsa003500.24646510
110Histidine metabolism_Homo sapiens_hsa003400.24375347
111Retinol metabolism_Homo sapiens_hsa008300.23668094
112Phenylalanine metabolism_Homo sapiens_hsa003600.23353161
113Collecting duct acid secretion_Homo sapiens_hsa049660.22781359
114Arachidonic acid metabolism_Homo sapiens_hsa005900.20981978
115Fatty acid elongation_Homo sapiens_hsa000620.19853299
116Nicotine addiction_Homo sapiens_hsa050330.17989725
117Linoleic acid metabolism_Homo sapiens_hsa005910.15929425

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