TFCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium-independent organic anion transport (GO:0043252)6.23882563
2mitotic sister chromatid cohesion (GO:0007064)5.85988212
3ribosome assembly (GO:0042255)5.25336016
4ncRNA catabolic process (GO:0034661)4.72914296
5nuclear pore complex assembly (GO:0051292)4.52780015
6DNA unwinding involved in DNA replication (GO:0006268)4.48095247
7positive regulation of endothelial cell differentiation (GO:0045603)4.37110709
8histone H2B ubiquitination (GO:0033523)4.26539180
9positive regulation of prostaglandin secretion (GO:0032308)4.17691197
10heterochromatin organization (GO:0070828)4.08909724
11monoubiquitinated protein deubiquitination (GO:0035520)4.01347777
12DNA topological change (GO:0006265)4.00093218
13mitotic sister chromatid segregation (GO:0000070)3.97175154
14nuclear pore organization (GO:0006999)3.96645860
15sister chromatid segregation (GO:0000819)3.93748229
16regulation of DNA endoreduplication (GO:0032875)3.90157758
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.85499901
18stress granule assembly (GO:0034063)3.84208021
19pre-miRNA processing (GO:0031054)3.83595995
20regulation of prostaglandin secretion (GO:0032306)3.78341183
21DNA double-strand break processing (GO:0000729)3.68306224
22atrial cardiac muscle cell action potential (GO:0086014)3.68197562
23auditory behavior (GO:0031223)3.67720318
24regulation of sister chromatid cohesion (GO:0007063)3.62907370
25CENP-A containing nucleosome assembly (GO:0034080)3.62544560
26chromatin remodeling at centromere (GO:0031055)3.61410273
27protein localization to synapse (GO:0035418)3.54668517
28NADPH regeneration (GO:0006740)3.53853867
29regulation of helicase activity (GO:0051095)3.50069578
30mitotic chromosome condensation (GO:0007076)3.46803146
31regulation of histone H3-K9 methylation (GO:0051570)3.44465463
32presynaptic membrane assembly (GO:0097105)3.37796478
33positive regulation of icosanoid secretion (GO:0032305)3.35667739
34negative regulation of histone methylation (GO:0031061)3.35278939
35pentose-phosphate shunt (GO:0006098)3.34930111
36positive regulation of macrophage activation (GO:0043032)3.34676623
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.31566770
38blastocyst development (GO:0001824)3.31384901
39negative regulation of membrane potential (GO:0045837)3.30932978
40establishment of integrated proviral latency (GO:0075713)3.29268195
41protein localization to kinetochore (GO:0034501)3.24399831
42histone H3-K9 demethylation (GO:0033169)3.21531062
43formation of translation preinitiation complex (GO:0001731)3.20817368
44negative regulation of DNA repair (GO:0045738)3.19342607
45neuron cell-cell adhesion (GO:0007158)3.17967300
46ribosomal large subunit biogenesis (GO:0042273)3.14716347
47pore complex assembly (GO:0046931)3.14553445
48DNA replication-independent nucleosome assembly (GO:0006336)3.13738217
49DNA replication-independent nucleosome organization (GO:0034724)3.13738217
50vitamin transmembrane transport (GO:0035461)3.09322421
51central nervous system myelination (GO:0022010)3.09194311
52axon ensheathment in central nervous system (GO:0032291)3.09194311
53mitotic nuclear envelope disassembly (GO:0007077)3.09021982
54DNA replication-dependent nucleosome assembly (GO:0006335)3.08958975
55DNA replication-dependent nucleosome organization (GO:0034723)3.08958975
56microtubule depolymerization (GO:0007019)3.06979925
57mechanosensory behavior (GO:0007638)3.06074185
58photoreceptor cell differentiation (GO:0046530)3.05800904
59eye photoreceptor cell differentiation (GO:0001754)3.05800904
60epithelial cell differentiation involved in kidney development (GO:0035850)3.05608202
61postsynaptic membrane organization (GO:0001941)3.03636530
62pyrimidine nucleobase catabolic process (GO:0006208)3.03441732
63regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.02736660
64definitive hemopoiesis (GO:0060216)3.02240968
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02076458
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02076458
67segment specification (GO:0007379)3.01613289
68regulation of DNA methylation (GO:0044030)3.01574633
69nephron epithelium morphogenesis (GO:0072088)3.00417818
70nephron tubule morphogenesis (GO:0072078)3.00417818
71regulation of RNA export from nucleus (GO:0046831)3.00169161
72negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99360428
73nuclear envelope disassembly (GO:0051081)2.98146097
74membrane disassembly (GO:0030397)2.98146097
75kinetochore organization (GO:0051383)2.97912584
76histone exchange (GO:0043486)2.96199991
77mRNA stabilization (GO:0048255)2.96054723
78RNA stabilization (GO:0043489)2.96054723
79positive regulation of fatty acid transport (GO:2000193)2.95164552
80presynaptic membrane organization (GO:0097090)2.94936935
81cerebral cortex radially oriented cell migration (GO:0021799)2.94494586
82positive regulation of mitochondrial fission (GO:0090141)2.93648574
83sister chromatid cohesion (GO:0007062)2.93475877
84negative regulation of mRNA metabolic process (GO:1903312)2.88120598
85cerebellar granule cell differentiation (GO:0021707)2.86414840
86startle response (GO:0001964)2.86066587
87resolution of meiotic recombination intermediates (GO:0000712)2.84545896
88negative regulation of mRNA processing (GO:0050686)2.84381641
89valine metabolic process (GO:0006573)2.83775572
90poly(A)+ mRNA export from nucleus (GO:0016973)2.83486703
91vocalization behavior (GO:0071625)2.82672330
92metaphase plate congression (GO:0051310)2.81976341
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.81784379
94negative regulation of sister chromatid segregation (GO:0033046)2.81784379
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81784379
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81784379
97negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81784379
98mitotic spindle checkpoint (GO:0071174)2.81336963
99dendrite development (GO:0016358)2.80896659
100negative regulation of DNA recombination (GO:0045910)2.80340501
101negative regulation of chromosome segregation (GO:0051985)2.79415351
102cartilage morphogenesis (GO:0060536)2.77448401
103response to auditory stimulus (GO:0010996)2.76695474
104establishment of viral latency (GO:0019043)2.76584464
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75859211
106synaptic transmission, glutamatergic (GO:0035249)2.75639682
107ATP-dependent chromatin remodeling (GO:0043044)2.74398306
108regulation of mRNA stability (GO:0043488)2.74336733
109protein localization to chromosome, centromeric region (GO:0071459)2.73244403
110regulation of centriole replication (GO:0046599)2.72573822
111non-recombinational repair (GO:0000726)2.72529766
112double-strand break repair via nonhomologous end joining (GO:0006303)2.72529766
113positive regulation of histone H3-K4 methylation (GO:0051571)2.72346172
114lung-associated mesenchyme development (GO:0060484)2.72127100
115DNA strand elongation involved in DNA replication (GO:0006271)2.71748648
116oligodendrocyte differentiation (GO:0048709)2.70992164
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70656210
118regulation of chromosome segregation (GO:0051983)2.70490162
119purine nucleobase metabolic process (GO:0006144)2.69937627
120negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.69745139
121mRNA splice site selection (GO:0006376)2.69050973
122regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68196262
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68196262
124regulation of endothelial cell differentiation (GO:0045601)2.67356392
125L-serine metabolic process (GO:0006563)2.67299139
126regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67000117
127DNA replication checkpoint (GO:0000076)2.66866689
128face development (GO:0060324)2.66810866
129spindle checkpoint (GO:0031577)2.66766610
130nucleobase biosynthetic process (GO:0046112)2.65856451
131neurotransmitter-gated ion channel clustering (GO:0072578)2.65571242
132negative regulation of RNA splicing (GO:0033119)2.64274240
133cellular hyperosmotic response (GO:0071474)2.64057183
134mitotic spindle assembly checkpoint (GO:0007094)2.63854538
135positive regulation of fatty acid biosynthetic process (GO:0045723)2.63833053
136mitotic metaphase plate congression (GO:0007080)2.63487451
1373-UTR-mediated mRNA stabilization (GO:0070935)2.61808956
138metanephric mesenchyme development (GO:0072075)2.58370163
139RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.57972722
140mRNA splicing, via spliceosome (GO:0000398)2.57972722
141RNA splicing, via transesterification reactions (GO:0000375)2.57862020
142purine nucleobase biosynthetic process (GO:0009113)2.57669103
143cell migration in hindbrain (GO:0021535)2.57114837
144spindle assembly checkpoint (GO:0071173)2.56405968
145regulation of mitotic sister chromatid segregation (GO:0033047)2.55633184
146regulation of sister chromatid segregation (GO:0033045)2.55633184
147regulation of mitotic sister chromatid separation (GO:0010965)2.55633184
148cranial nerve morphogenesis (GO:0021602)2.55052088
149mitotic G2/M transition checkpoint (GO:0044818)2.54620608
150synaptic vesicle endocytosis (GO:0048488)2.53688734
151negative regulation of astrocyte differentiation (GO:0048712)2.50006904
152neuron recognition (GO:0008038)2.48435351
153microtubule polymerization or depolymerization (GO:0031109)2.45650589
154cranial nerve structural organization (GO:0021604)2.42890828
155dendrite morphogenesis (GO:0048813)2.42465484
156regulation of icosanoid secretion (GO:0032303)2.41970432
157kidney mesenchyme development (GO:0072074)2.41902767
158positive regulation of dendritic spine development (GO:0060999)2.40246302
159apical protein localization (GO:0045176)2.40121845
160positive regulation of male gonad development (GO:2000020)2.39681995
161glomerulus development (GO:0032835)2.38143703
162neuron remodeling (GO:0016322)2.37424643
163hippocampus development (GO:0021766)2.37251285
164glucocorticoid receptor signaling pathway (GO:0042921)2.36916305
165response to pheromone (GO:0019236)2.36567097
166negative regulation of dendrite morphogenesis (GO:0050774)2.35769063
167axonal fasciculation (GO:0007413)2.35622328
168central nervous system projection neuron axonogenesis (GO:0021952)2.35070266
169facial nerve structural organization (GO:0021612)2.33085226
170regulation of male gonad development (GO:2000018)2.32904272
171regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.30774128
172layer formation in cerebral cortex (GO:0021819)2.30683492
173establishment of mitochondrion localization (GO:0051654)2.29702202
174limb bud formation (GO:0060174)2.29311675
175regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29262406
176negative regulation of glycogen biosynthetic process (GO:0045719)2.29058335
177transmission of nerve impulse (GO:0019226)2.27910547
178preassembly of GPI anchor in ER membrane (GO:0016254)2.27475979
179central nervous system neuron axonogenesis (GO:0021955)2.27046730
180spinal cord development (GO:0021510)2.26781886
181negative regulation of glycogen metabolic process (GO:0070874)2.26422626
182replicative senescence (GO:0090399)2.26075662
183positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.25169948
184neuronal ion channel clustering (GO:0045161)2.24955377
185melanin biosynthetic process (GO:0042438)2.24377475
186positive regulation of organic acid transport (GO:0032892)2.24280078
187positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.22819445
188regulation of timing of cell differentiation (GO:0048505)2.22701160
189neuron-neuron synaptic transmission (GO:0007270)2.21209604
190renal tubule morphogenesis (GO:0061333)2.20682034
191dermatan sulfate biosynthetic process (GO:0030208)2.20322708
192negative regulation of dendrite development (GO:2000171)2.18612509
193positive regulation of action potential (GO:0045760)2.17847271
194positive regulation of synapse assembly (GO:0051965)2.17634880
195regulation of postsynaptic membrane potential (GO:0060078)2.16458110
196ear development (GO:0043583)2.15787896
197ionotropic glutamate receptor signaling pathway (GO:0035235)2.15556894
198positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.12421703
199mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.12421703
200regulation of synapse maturation (GO:0090128)2.12037478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.99419364
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.30856565
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.71298213
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64500557
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.41035960
6ZNF274_21170338_ChIP-Seq_K562_Hela3.32428610
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.25561822
8EZH2_22144423_ChIP-Seq_EOC_Human3.14882571
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.95272327
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.75355343
11GBX2_23144817_ChIP-Seq_PC3_Human2.70663187
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.60281142
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.55986985
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46322689
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37303963
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33025822
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27751997
18RNF2_27304074_Chip-Seq_NSC_Mouse2.25247534
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21174744
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20738718
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20738718
22* ELK1_19687146_ChIP-ChIP_HELA_Human2.19165765
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18526807
24TP63_19390658_ChIP-ChIP_HaCaT_Human2.13713600
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.13099512
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10756668
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.06037200
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01779793
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01260497
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97592870
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.96847982
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95145965
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93543738
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92373124
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89779356
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89568799
37TAF15_26573619_Chip-Seq_HEK293_Human1.86950689
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86661982
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85577007
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84647605
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84139820
42* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83033740
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82826085
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82071385
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81542135
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81259223
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78813188
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.78163815
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77419984
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77419984
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77419984
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74119577
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.73911813
54TTF2_22483619_ChIP-Seq_HELA_Human1.73148233
55MYC_22102868_ChIP-Seq_BL_Human1.72535180
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72496076
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.72060892
58FOXP3_21729870_ChIP-Seq_TREG_Human1.71828244
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71161114
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68224585
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67714504
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.66786941
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66534741
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.66447293
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65253103
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.62250671
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61416058
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58784447
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.58538638
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57559069
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57556845
72CLOCK_20551151_ChIP-Seq_293T_Human1.56027916
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.54895827
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54662543
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54629878
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.54293572
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53528104
78AR_21909140_ChIP-Seq_LNCAP_Human1.51289336
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48495034
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45988892
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.45407964
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43661702
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42812237
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42743258
85FUS_26573619_Chip-Seq_HEK293_Human1.42525154
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42514752
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42016151
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41757118
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41458109
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41128030
91P300_19829295_ChIP-Seq_ESCs_Human1.39401960
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37626913
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37268968
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.35787063
95REST_21632747_ChIP-Seq_MESCs_Mouse1.35275154
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35109143
97SMAD4_21799915_ChIP-Seq_A2780_Human1.34840289
98TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31975590
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.31335988
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31056258
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.28641073
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28302621
103AR_25329375_ChIP-Seq_VCAP_Human1.28202935
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27731079
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27714784
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26958843
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26958843
108ER_23166858_ChIP-Seq_MCF-7_Human1.26395152
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24592040
110* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24337719
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23861745
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23829701
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23803036
114MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23270719
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22509546
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21536058
117VDR_23849224_ChIP-Seq_CD4+_Human1.21421140
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20224748
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19096545
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18162354
121TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17948157
122SOX9_26525672_Chip-Seq_HEART_Mouse1.17887489
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15998424
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.14873555
125NANOG_16153702_ChIP-ChIP_HESCs_Human1.14537356
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14490622
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.13243640
128XRN2_22483619_ChIP-Seq_HELA_Human1.10486278
129STAT3_23295773_ChIP-Seq_U87_Human1.10111639
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09933588
131ETS1_20019798_ChIP-Seq_JURKAT_Human1.09153770
132REST_18959480_ChIP-ChIP_MESCs_Mouse1.07059489
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.04989371
134ISL1_27105846_Chip-Seq_CPCs_Mouse1.04828522
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04741179
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04445281
137SOX2_16153702_ChIP-ChIP_HESCs_Human1.04433500
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04356463
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03530423
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03081399
141ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03079456
142NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02599024
143E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02422684
144VDR_22108803_ChIP-Seq_LS180_Human1.02241556
145TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01832626
146LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01432102
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01358027
148JUN_21703547_ChIP-Seq_K562_Human1.00345544
149POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99934914
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.99649449
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98053768
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97204305
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96823975
154EWS_26573619_Chip-Seq_HEK293_Human0.96136322
155SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95946155
156LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95457239
157THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95247796
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94848380
159TRIM28_21343339_ChIP-Seq_HEK293_Human0.94528892
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93639538
161CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92855148
162GF1B_26923725_Chip-Seq_HPCs_Mouse0.92531169
163WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92409425
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90885753
165UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90636792
166PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90466933
167TP53_18474530_ChIP-ChIP_U2OS_Human0.90067532
168NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88905735
169E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88790854
170RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86132487
171POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84639463
172SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83826197
173FLI1_27457419_Chip-Seq_LIVER_Mouse0.82989992
174DCP1A_22483619_ChIP-Seq_HELA_Human0.80774945
175TBX3_20139965_ChIP-Seq_MESCs_Mouse0.80431256
176ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80206104
177* TFEB_21752829_ChIP-Seq_HELA_Human0.80058879
178MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.78120580
179TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77767963
180SPI1_23547873_ChIP-Seq_NB4_Human0.77349042
181ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76806924
182POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76401203
183PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.75978707
184CIITA_25753668_ChIP-Seq_RAJI_Human0.75816489
185TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.75392687
186NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74775264
187CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74319549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.97269940
2MP0003693_abnormal_embryo_hatching3.42821339
3MP0010094_abnormal_chromosome_stability3.25182033
4MP0002653_abnormal_ependyma_morphology3.10050118
5MP0003880_abnormal_central_pattern2.97618303
6MP0008007_abnormal_cellular_replicative2.90272618
7MP0003077_abnormal_cell_cycle2.75216716
8MP0002009_preneoplasia2.62976733
9MP0004957_abnormal_blastocyst_morpholog2.50331603
10MP0003122_maternal_imprinting2.44793371
11MP0003136_yellow_coat_color2.42254542
12MP0003121_genomic_imprinting2.30363804
13MP0005171_absent_coat_pigmentation2.25029556
14MP0000490_abnormal_crypts_of2.23038731
15MP0004742_abnormal_vestibular_system2.20467567
16MP0003890_abnormal_embryonic-extraembry2.18685771
17MP0003787_abnormal_imprinting2.15681425
18MP0001730_embryonic_growth_arrest2.15404735
19MP0004859_abnormal_synaptic_plasticity2.14544586
20MP0006292_abnormal_olfactory_placode2.06189989
21MP0005646_abnormal_pituitary_gland2.06160849
22MP0001486_abnormal_startle_reflex2.02903226
23MP0003635_abnormal_synaptic_transmissio1.92808051
24MP0003111_abnormal_nucleus_morphology1.92749690
25MP0000566_synostosis1.92277068
26MP0001915_intracranial_hemorrhage1.91516241
27MP0003938_abnormal_ear_development1.90927302
28MP0000778_abnormal_nervous_system1.90519558
29MP0008932_abnormal_embryonic_tissue1.90115503
30MP0009046_muscle_twitch1.86417278
31MP0003172_abnormal_lysosome_physiology1.86408911
32MP0000534_abnormal_ureter_morphology1.84249884
33MP0002396_abnormal_hematopoietic_system1.78592323
34MP0008058_abnormal_DNA_repair1.75636755
35MP0002736_abnormal_nociception_after1.74083493
36MP0009745_abnormal_behavioral_response1.73149810
37MP0002085_abnormal_embryonic_tissue1.72902115
38MP0002084_abnormal_developmental_patter1.70250532
39MP0000350_abnormal_cell_proliferation1.69293718
40MP0001293_anophthalmia1.64475178
41MP0003937_abnormal_limbs/digits/tail_de1.64353464
42MP0003718_maternal_effect1.63854903
43MP0004270_analgesia1.62710726
44MP0000428_abnormal_craniofacial_morphol1.61520512
45MP0002272_abnormal_nervous_system1.61149933
46MP0010030_abnormal_orbit_morphology1.57617667
47MP0001672_abnormal_embryogenesis/_devel1.57569480
48MP0005380_embryogenesis_phenotype1.57569480
49MP0002064_seizures1.57307404
50MP0008877_abnormal_DNA_methylation1.56888158
51MP0001697_abnormal_embryo_size1.56313101
52MP0009250_abnormal_appendicular_skeleto1.54315072
53MP0000049_abnormal_middle_ear1.52802265
54MP0004808_abnormal_hematopoietic_stem1.52554161
55MP0002254_reproductive_system_inflammat1.51078659
56MP0003763_abnormal_thymus_physiology1.50642944
57MP0009278_abnormal_bone_marrow1.50345053
58MP0003984_embryonic_growth_retardation1.49669140
59MP0003942_abnormal_urinary_system1.48658093
60MP0002088_abnormal_embryonic_growth/wei1.47998684
61MP0001968_abnormal_touch/_nociception1.44516960
62MP0000569_abnormal_digit_pigmentation1.44297351
63MP0002249_abnormal_larynx_morphology1.40555773
64MP0003567_abnormal_fetal_cardiomyocyte1.38983284
65MP0009672_abnormal_birth_weight1.38085295
66MP0009703_decreased_birth_body1.37437751
67MP0000026_abnormal_inner_ear1.36963325
68MP0002557_abnormal_social/conspecific_i1.36509109
69MP0002063_abnormal_learning/memory/cond1.33591604
70MP0000372_irregular_coat_pigmentation1.33318797
71MP0000631_abnormal_neuroendocrine_gland1.32969232
72MP0002067_abnormal_sensory_capabilities1.31340223
73MP0004885_abnormal_endolymph1.30314648
74MP0002734_abnormal_mechanical_nocicepti1.30281458
75MP0002080_prenatal_lethality1.29987519
76MP0002882_abnormal_neuron_morphology1.28939979
77MP0002184_abnormal_innervation1.27635529
78MP0000703_abnormal_thymus_morphology1.26909226
79MP0005423_abnormal_somatic_nervous1.26539255
80MP0002102_abnormal_ear_morphology1.25559612
81MP0001485_abnormal_pinna_reflex1.24864837
82MP0002938_white_spotting1.24595020
83MP0001963_abnormal_hearing_physiology1.21741182
84MP0002233_abnormal_nose_morphology1.21253530
85MP0010386_abnormal_urinary_bladder1.19888082
86MP0003385_abnormal_body_wall1.18777608
87MP0002752_abnormal_somatic_nervous1.18363989
88MP0002277_abnormal_respiratory_mucosa1.17838420
89MP0003315_abnormal_perineum_morphology1.16994261
90MP0000313_abnormal_cell_death1.14734992
91MP0008789_abnormal_olfactory_epithelium1.14438080
92MP0006276_abnormal_autonomic_nervous1.14435152
93MP0004145_abnormal_muscle_electrophysio1.13192113
94MP0001727_abnormal_embryo_implantation1.11016547
95MP0005551_abnormal_eye_electrophysiolog1.08961286
96MP0000432_abnormal_head_morphology1.08235004
97MP0002572_abnormal_emotion/affect_behav1.07783458
98MP0004811_abnormal_neuron_physiology1.07210250
99MP0002697_abnormal_eye_size1.07145329
100MP0005623_abnormal_meninges_morphology1.07144035
101MP0003755_abnormal_palate_morphology1.06975922
102MP0001502_abnormal_circadian_rhythm1.06554470
103MP0002111_abnormal_tail_morphology1.06540659
104MP0004197_abnormal_fetal_growth/weight/1.06278424
105MP0003123_paternal_imprinting1.04809887
106MP0003878_abnormal_ear_physiology1.04742329
107MP0005377_hearing/vestibular/ear_phenot1.04742329
108MP0002177_abnormal_outer_ear1.03197201
109MP0001286_abnormal_eye_development1.02376314
110MP0003690_abnormal_glial_cell1.02253478
111MP0002877_abnormal_melanocyte_morpholog1.01801087
112MP0002932_abnormal_joint_morphology1.00989119
113MP0004142_abnormal_muscle_tone0.98597265
114MP0003329_amyloid_beta_deposits0.98355117
115MP0009333_abnormal_splenocyte_physiolog0.97932584
116MP0010368_abnormal_lymphatic_system0.97688776
117MP0005408_hypopigmentation0.97477293
118MP0005499_abnormal_olfactory_system0.97312639
119MP0005394_taste/olfaction_phenotype0.97312639
120MP0004133_heterotaxia0.97242491
121MP0000955_abnormal_spinal_cord0.96903335
122MP0001905_abnormal_dopamine_level0.96371229
123MP0005248_abnormal_Harderian_gland0.95340765
124MP0005409_darkened_coat_color0.94932065
125MP0005174_abnormal_tail_pigmentation0.94081355
126MP0004084_abnormal_cardiac_muscle0.92053607
127MP0005645_abnormal_hypothalamus_physiol0.91699777
128MP0002086_abnormal_extraembryonic_tissu0.90607140
129MP0001188_hyperpigmentation0.89770429
130MP0002092_abnormal_eye_morphology0.89617303
131MP0003861_abnormal_nervous_system0.89404542
132MP0000751_myopathy0.87629027
133MP0001984_abnormal_olfaction0.87495887
134MP0000516_abnormal_urinary_system0.87019422
135MP0005367_renal/urinary_system_phenotyp0.87019422
136MP0002152_abnormal_brain_morphology0.86478073
137MP0005253_abnormal_eye_physiology0.86331106
138MP0002116_abnormal_craniofacial_bone0.86190464
139MP0002234_abnormal_pharynx_morphology0.85794879
140MP0002229_neurodegeneration0.84783171
141MP0004510_myositis0.84754831
142MP0000015_abnormal_ear_pigmentation0.83896202
143MP0001177_atelectasis0.83531724
144MP0010307_abnormal_tumor_latency0.83134647
145MP0002114_abnormal_axial_skeleton0.83021460
146MP0002733_abnormal_thermal_nociception0.82893869
147MP0003221_abnormal_cardiomyocyte_apopto0.82821811
148MP0003935_abnormal_craniofacial_develop0.82488871
149MP0001346_abnormal_lacrimal_gland0.81166561
150MP0003941_abnormal_skin_development0.81073344
151MP0005386_behavior/neurological_phenoty0.80098001
152MP0004924_abnormal_behavior0.80098001
153MP0002081_perinatal_lethality0.79834493
154MP0004085_abnormal_heartbeat0.79621407
155MP0002066_abnormal_motor_capabilities/c0.79405111
156MP0003115_abnormal_respiratory_system0.79372934
157MP0002925_abnormal_cardiovascular_devel0.79186281
158MP0001919_abnormal_reproductive_system0.79163098
159MP0000537_abnormal_urethra_morphology0.79049373
160MP0001440_abnormal_grooming_behavior0.78274355
161MP0006035_abnormal_mitochondrial_morpho0.77488985
162MP0001849_ear_inflammation0.74363244
163MP0003943_abnormal_hepatobiliary_system0.71567751
164MP0010352_gastrointestinal_tract_polyps0.69433845
165MP0002405_respiratory_system_inflammati0.65301344
166MP0000579_abnormal_nail_morphology0.65171319
167MP0002398_abnormal_bone_marrow0.64727890
168MP0002109_abnormal_limb_morphology0.63450630

Predicted human phenotypes

RankGene SetZ-score
1Increased nuchal translucency (HP:0010880)4.58807877
2Nonprogressive disorder (HP:0003680)3.92395223
3Abnormality of oral frenula (HP:0000190)3.59805008
4Ankyloglossia (HP:0010296)3.58826536
5Abnormal hair whorl (HP:0010721)3.19900612
6Focal motor seizures (HP:0011153)3.14516647
7Esophageal atresia (HP:0002032)3.11462993
8Abnormality of chromosome stability (HP:0003220)3.04877846
9Adrenal hypoplasia (HP:0000835)3.02576223
10Proximal placement of thumb (HP:0009623)2.97522993
11Abnormality of the labia minora (HP:0012880)2.96541900
12Centrally nucleated skeletal muscle fibers (HP:0003687)2.92463311
13Obsessive-compulsive behavior (HP:0000722)2.87263982
14True hermaphroditism (HP:0010459)2.77820079
15Abnormality of the preputium (HP:0100587)2.76121672
16Deviation of the thumb (HP:0009603)2.72276613
17Large earlobe (HP:0009748)2.70615713
18Pancreatic fibrosis (HP:0100732)2.69790267
19Fetal akinesia sequence (HP:0001989)2.67970740
20Agnosia (HP:0010524)2.66772266
21Hypoplasia of the pons (HP:0012110)2.65443743
22Metaphyseal cupping (HP:0003021)2.65154007
23Meckel diverticulum (HP:0002245)2.62581396
24Epileptic encephalopathy (HP:0200134)2.62484391
25Amniotic constriction ring (HP:0009775)2.61752154
26Abnormality of placental membranes (HP:0011409)2.61752154
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.60399414
28Absent/shortened dynein arms (HP:0200106)2.60399414
29Abnormality of the pons (HP:0007361)2.59862710
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.58105894
31Aplasia involving bones of the extremities (HP:0009825)2.55432172
32Aplasia involving bones of the upper limbs (HP:0009823)2.55432172
33Aplasia of the phalanges of the hand (HP:0009802)2.55432172
34Bell-shaped thorax (HP:0001591)2.50984950
35Abnormality of the ileum (HP:0001549)2.44926247
36Colon cancer (HP:0003003)2.44234766
37Ridged nail (HP:0001807)2.41531057
38Choanal atresia (HP:0000453)2.40396939
39Chronic bronchitis (HP:0004469)2.38951459
40Poor suck (HP:0002033)2.37247277
41Gastrointestinal atresia (HP:0002589)2.37031854
42Exercise-induced muscle cramps (HP:0003710)2.36976313
43Weak cry (HP:0001612)2.35972841
44Cortical dysplasia (HP:0002539)2.33292403
45Selective tooth agenesis (HP:0001592)2.31074296
46Acute myeloid leukemia (HP:0004808)2.28716257
47Renal cortical cysts (HP:0000803)2.27605408
48Abnormal respiratory motile cilium physiology (HP:0012261)2.26727736
49Pancreatic cysts (HP:0001737)2.22153930
50Osteomalacia (HP:0002749)2.21712606
51Round ear (HP:0100830)2.12055371
52Nephronophthisis (HP:0000090)2.11846934
53Cutis marmorata (HP:0000965)2.11846182
54Spastic diplegia (HP:0001264)2.09619344
55Split foot (HP:0001839)2.09523177
56Premature loss of primary teeth (HP:0006323)2.08897439
57Febrile seizures (HP:0002373)2.08510376
58Nasal speech (HP:0001611)2.08011615
59Restlessness (HP:0000711)2.05763284
60Coarctation of aorta (HP:0001680)2.04171786
61Spinal rigidity (HP:0003306)2.03823649
62Abnormality of cochlea (HP:0000375)2.03071324
63Hypoventilation (HP:0002791)2.02922788
64Carpal bone hypoplasia (HP:0001498)2.02740820
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.02566892
66Blepharitis (HP:0000498)2.02252687
67Low anterior hairline (HP:0000294)2.02189800
68Atresia of the external auditory canal (HP:0000413)2.02159498
69Hypoplastic left heart (HP:0004383)2.02031059
70Protruding tongue (HP:0010808)2.01133447
71Reduced antithrombin III activity (HP:0001976)2.00129155
72Aplasia/Hypoplasia of the fovea (HP:0008060)1.98990899
73Hypoplasia of the fovea (HP:0007750)1.98990899
74Abnormal lung lobation (HP:0002101)1.98848182
75Abnormality of midbrain morphology (HP:0002418)1.98777820
76Molar tooth sign on MRI (HP:0002419)1.98777820
77Gait imbalance (HP:0002141)1.98574793
78Medulloblastoma (HP:0002885)1.96037249
79Rectal fistula (HP:0100590)1.95087093
80Rectovaginal fistula (HP:0000143)1.95087093
81Nephroblastoma (Wilms tumor) (HP:0002667)1.93866875
82Astrocytoma (HP:0009592)1.92595336
83Abnormality of the astrocytes (HP:0100707)1.92595336
84Blue irides (HP:0000635)1.92558604
85Turricephaly (HP:0000262)1.92504140
86Abnormality of chromosome segregation (HP:0002916)1.92457129
87Truncal obesity (HP:0001956)1.91758315
88Breech presentation (HP:0001623)1.91697365
89Xerostomia (HP:0000217)1.91345300
90Abnormal ciliary motility (HP:0012262)1.91309167
91Calcaneovalgus deformity (HP:0001848)1.90178521
92Narrow nasal bridge (HP:0000446)1.89793353
93Abnormality of abdominal situs (HP:0011620)1.88661837
94Abdominal situs inversus (HP:0003363)1.88661837
95Morphological abnormality of the inner ear (HP:0011390)1.87697694
96Limb hypertonia (HP:0002509)1.87449534
97Radioulnar synostosis (HP:0002974)1.87213898
98Overriding aorta (HP:0002623)1.87162121
99Pustule (HP:0200039)1.86736778
100Abnormality of the carotid arteries (HP:0005344)1.86283437
101Overlapping toe (HP:0001845)1.84229027
102Abnormality of macular pigmentation (HP:0008002)1.83870525
103Hypoplastic heart (HP:0001961)1.83372487
104Intestinal fistula (HP:0100819)1.83151548
105Oligodactyly (hands) (HP:0001180)1.81124866
106Duodenal stenosis (HP:0100867)1.81099101
107Small intestinal stenosis (HP:0012848)1.81099101
108Transitional cell carcinoma of the bladder (HP:0006740)1.80994016
109Anencephaly (HP:0002323)1.80568121
110Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80062317
111Hypoplasia of the brainstem (HP:0002365)1.80062317
112Atelectasis (HP:0100750)1.79715707
113Missing ribs (HP:0000921)1.79450174
114Malignant gastrointestinal tract tumors (HP:0006749)1.78724138
115Gastrointestinal carcinoma (HP:0002672)1.78724138
116Embryonal renal neoplasm (HP:0011794)1.78528685
117Intestinal malrotation (HP:0002566)1.78119026
118Central scotoma (HP:0000603)1.77479578
119Amyotrophic lateral sclerosis (HP:0007354)1.77453438
120Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77159802
121Hepatoblastoma (HP:0002884)1.76654538
122Median cleft lip (HP:0000161)1.75835485
123Failure to thrive in infancy (HP:0001531)1.75790754
124Ependymoma (HP:0002888)1.75527517
125Abnormality of the renal cortex (HP:0011035)1.75156734
126Septo-optic dysplasia (HP:0100842)1.74998820
127IgM deficiency (HP:0002850)1.74788063
128Excessive salivation (HP:0003781)1.74575313
129Drooling (HP:0002307)1.74575313
130Anal stenosis (HP:0002025)1.74042151
131Congenital primary aphakia (HP:0007707)1.73184374
132Hypoplastic labia majora (HP:0000059)1.73149629
133Glioma (HP:0009733)1.71507594
134Ectopic kidney (HP:0000086)1.70879263
135Abnormality of the duodenum (HP:0002246)1.70186920
136Widely patent fontanelles and sutures (HP:0004492)1.70177336
137Microvesicular hepatic steatosis (HP:0001414)1.69660549
138Shawl scrotum (HP:0000049)1.69445294
139Anophthalmia (HP:0000528)1.68457958
140Increased variability in muscle fiber diameter (HP:0003557)1.68250106
141Anteriorly placed anus (HP:0001545)1.68111456
142Tracheoesophageal fistula (HP:0002575)1.67015049
143Midline defect of the nose (HP:0004122)1.66315784
144Hypoplastic nipples (HP:0002557)1.66125093
145Focal seizures (HP:0007359)1.65493667
146Myelodysplasia (HP:0002863)1.65444206
147Abnormality of the renal medulla (HP:0100957)1.65268469
148Pointed chin (HP:0000307)1.65146141
149Split hand (HP:0001171)1.64965268
150Birth length less than 3rd percentile (HP:0003561)1.63484155
151Long clavicles (HP:0000890)1.63395432
152Aplasia/Hypoplasia of the sternum (HP:0006714)1.63245209
153Volvulus (HP:0002580)1.63016956
154Elfin facies (HP:0004428)1.62391006
155Chin dimple (HP:0010751)1.61857212
156Keratoconus (HP:0000563)1.61213333
157Increased corneal curvature (HP:0100692)1.61213333
158Uterine leiomyosarcoma (HP:0002891)1.60901886
159Leiomyosarcoma (HP:0100243)1.60901886
160Genital tract atresia (HP:0001827)1.60618415
161Cheilitis (HP:0100825)1.60218902
162Nephrogenic diabetes insipidus (HP:0009806)1.60160481
163Horseshoe kidney (HP:0000085)1.59934635
164Abnormality of the antihelix (HP:0009738)1.58682936
165Medial flaring of the eyebrow (HP:0010747)1.58671129
166Hypoplastic female external genitalia (HP:0012815)1.58500921
167Abnormality of the labia majora (HP:0012881)1.58353721
168Stenosis of the external auditory canal (HP:0000402)1.58137485
169Short palm (HP:0004279)1.57895151
170Abnormality of the hip-girdle musculature (HP:0001445)1.57744110
171Abnormality of the musculature of the pelvis (HP:0001469)1.57744110
172Vaginal atresia (HP:0000148)1.55572050
173Vaginal fistula (HP:0004320)1.54950142
174Aqueductal stenosis (HP:0002410)1.54358240
175Broad nasal tip (HP:0000455)1.52908424
176Hypothermia (HP:0002045)1.52600660
177High pitched voice (HP:0001620)1.51023686
178Narrow forehead (HP:0000341)1.48407279
179Optic nerve hypoplasia (HP:0000609)1.48395536
180Wide cranial sutures (HP:0010537)1.47841967
181Renal hypoplasia (HP:0000089)1.47710267
182Abnormality of molar (HP:0011077)1.47684003
183Abnormality of molar morphology (HP:0011070)1.47684003
184Generalized hypopigmentation of hair (HP:0011358)1.46687899
185Abnormality of permanent molar morphology (HP:0011071)1.46683308
186Abnormality of the dental root (HP:0006486)1.46683308
187Taurodontia (HP:0000679)1.46683308
188Supernumerary spleens (HP:0009799)1.46228265
189Bifid tongue (HP:0010297)1.46224459
190Poor coordination (HP:0002370)1.46196260
191Pheochromocytoma (HP:0002666)1.46157560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K76.45870370
2MAP3K46.14042711
3PNCK4.18425632
4CASK3.47841106
5MAP2K43.35484310
6CDK193.14540060
7AKT32.92939479
8MAP3K102.69985986
9CDC72.66034994
10SRPK12.63066669
11STK38L2.59420585
12TTK2.38212483
13MUSK2.35401791
14BRD42.33781938
15CDK122.03504134
16WEE11.98278133
17ERBB31.86634081
18BRSK21.77953843
19MAP3K141.75219050
20MAP3K131.70403213
21MKNK11.68921111
22CAMKK21.67835668
23CAMK1D1.66240180
24DMPK1.64242218
25RAF11.61478006
26PRPF4B1.58880484
27KIT1.56708974
28MARK11.54134346
29TAF11.53810633
30CSNK1G31.49801846
31PINK11.45868149
32CSNK1A1L1.44329118
33NEK61.44005616
34SGK21.42967948
35SGK4941.40446440
36SGK2231.40446440
37ZAK1.39196728
38MAPK131.35020123
39BCR1.34418797
40KSR21.34053793
41CAMK1G1.33224715
42RPS6KA41.32562983
43BUB11.24577003
44MKNK21.24361948
45VRK21.22605656
46PRKD31.19243655
47SIK31.17613043
48CSNK1G11.17274996
49NTRK21.15717894
50OXSR11.15466025
51RIPK41.14372118
52CCNB11.13759469
53CSNK1G21.13398004
54ATR1.09562451
55LATS11.09312982
56FES1.07016263
57CLK11.05367357
58CDK81.04752078
59* CDK31.02521560
60TYRO31.01700053
61DYRK31.01244443
62NEK21.00623429
63DYRK20.98970917
64CHEK10.95889604
65STK390.94610105
66FGR0.93450517
67STK380.93031431
68NTRK30.92817226
69YES10.92598902
70LATS20.91718781
71DDR20.91515398
72ATM0.91454755
73CSF1R0.90125498
74TNIK0.90076103
75PLK40.90048479
76WNK30.89220584
77MYLK0.88474962
78CDK40.85253959
79VRK10.84971285
80MINK10.83433366
81EPHA40.82917876
82TRIM280.81054093
83CDK60.80671587
84PLK20.79657686
85SGK30.78109249
86PLK30.76355133
87MAP3K80.75629800
88PHKG10.69994756
89PHKG20.69994756
90MAPK70.69980648
91RET0.69451374
92UHMK10.66991110
93ERBB40.66351438
94CSK0.63691107
95STK100.63575397
96PLK10.63058394
97PRKAA10.62045442
98GRK60.60757116
99NEK90.60593362
100PRKCE0.59658553
101STK240.58818110
102MAP3K20.58477275
103ICK0.56746708
104PRKDC0.56494707
105SMG10.56450004
106TAOK10.56063197
107AURKB0.55844641
108* CDK20.54753093
109CAMKK10.54349573
110PRKCG0.53175743
111EPHB20.52455634
112BRSK10.51436075
113PAK60.50364694
114TSSK60.49972837
115TNK20.48192965
116KSR10.48101608
117GRK10.45181063
118NME10.45132479
119CSNK1A10.44867338
120EIF2AK30.44389787
121CAMK10.44337521
122EIF2AK10.43981536
123CAMK2A0.43722144
124MARK20.43321204
125ERBB20.42863926
126NLK0.42115260
127SYK0.41937193
128PASK0.41669811
129BMPR1B0.41092855
130CDK50.41092823
131RPS6KB10.40796848
132MATK0.40284245
133PRKCH0.40273921
134STK30.39431818
135PKN10.39399392
136STK160.39297190
137TEC0.39293011
138CHEK20.39225042
139STK40.39191567
140NEK10.37394628
141CAMK2G0.37197756
142SGK10.36962572
143PBK0.36544360
144SIK20.36457226
145BRAF0.36355888
146WNK40.36336791
147MST40.35982959
148MAP3K90.35937495
149CAMK2B0.35935688
150JAK30.35565873
151PRKACB0.34758036
152CSNK1E0.34297842
153PTK60.33911683
154PAK30.33472257
155NUAK10.32700635
156ALK0.32403072
157NTRK10.31976894
158EIF2AK20.31623731
159GSK3B0.31385882
160CAMK40.31368040
161CDK180.30940481
162OBSCN0.30936518
163TRPM70.30892889
164CAMK2D0.29767060
165CDK10.29136970
166MAPK100.29053838

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.67091048
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.01629550
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.98876581
4DNA replication_Homo sapiens_hsa030302.80887168
5Basal transcription factors_Homo sapiens_hsa030222.69722089
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.58735336
7Vitamin B6 metabolism_Homo sapiens_hsa007502.55422246
8Nicotine addiction_Homo sapiens_hsa050332.53525254
9Non-homologous end-joining_Homo sapiens_hsa034502.50168850
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48128722
11Selenocompound metabolism_Homo sapiens_hsa004502.29584550
12Nucleotide excision repair_Homo sapiens_hsa034202.23775373
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11275880
14Axon guidance_Homo sapiens_hsa043602.04795428
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02141652
16Base excision repair_Homo sapiens_hsa034101.99526791
17RNA degradation_Homo sapiens_hsa030181.96807764
18RNA polymerase_Homo sapiens_hsa030201.84004888
19Adherens junction_Homo sapiens_hsa045201.81832584
20GABAergic synapse_Homo sapiens_hsa047271.76812480
21Melanoma_Homo sapiens_hsa052181.71228811
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69969827
23Phototransduction_Homo sapiens_hsa047441.68683204
24Glutamatergic synapse_Homo sapiens_hsa047241.66689038
25Protein export_Homo sapiens_hsa030601.65609721
26Wnt signaling pathway_Homo sapiens_hsa043101.64806082
27ErbB signaling pathway_Homo sapiens_hsa040121.62461787
28Synaptic vesicle cycle_Homo sapiens_hsa047211.61018524
29Basal cell carcinoma_Homo sapiens_hsa052171.54830138
30Serotonergic synapse_Homo sapiens_hsa047261.53263534
31Morphine addiction_Homo sapiens_hsa050321.46258028
32Circadian entrainment_Homo sapiens_hsa047131.42481336
33Cell cycle_Homo sapiens_hsa041101.37760114
34Homologous recombination_Homo sapiens_hsa034401.34851987
35Circadian rhythm_Homo sapiens_hsa047101.33932006
36Taste transduction_Homo sapiens_hsa047421.28008578
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27712908
38Dopaminergic synapse_Homo sapiens_hsa047281.27389250
39Steroid biosynthesis_Homo sapiens_hsa001001.25089019
40Chronic myeloid leukemia_Homo sapiens_hsa052201.22597356
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18461810
42Ribosome_Homo sapiens_hsa030101.17898527
43Oocyte meiosis_Homo sapiens_hsa041141.16372548
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16198937
45Hedgehog signaling pathway_Homo sapiens_hsa043401.16087659
46Prostate cancer_Homo sapiens_hsa052151.16060937
47Cocaine addiction_Homo sapiens_hsa050301.12524876
48Colorectal cancer_Homo sapiens_hsa052101.11751256
49Hippo signaling pathway_Homo sapiens_hsa043901.10359775
50Endometrial cancer_Homo sapiens_hsa052131.07458021
51Butanoate metabolism_Homo sapiens_hsa006501.06554380
52B cell receptor signaling pathway_Homo sapiens_hsa046621.05554514
53Choline metabolism in cancer_Homo sapiens_hsa052311.05036903
54Insulin secretion_Homo sapiens_hsa049111.03932154
55Melanogenesis_Homo sapiens_hsa049161.03698177
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01680188
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00667782
58GnRH signaling pathway_Homo sapiens_hsa049120.98308582
59Herpes simplex infection_Homo sapiens_hsa051680.98295154
60Renal cell carcinoma_Homo sapiens_hsa052110.97814632
61Ras signaling pathway_Homo sapiens_hsa040140.95423773
62Amphetamine addiction_Homo sapiens_hsa050310.94743465
63mRNA surveillance pathway_Homo sapiens_hsa030150.94667051
64Purine metabolism_Homo sapiens_hsa002300.93878717
65Hepatitis B_Homo sapiens_hsa051610.93814104
66Cholinergic synapse_Homo sapiens_hsa047250.92893818
67Pyrimidine metabolism_Homo sapiens_hsa002400.91575352
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91125193
69Leishmaniasis_Homo sapiens_hsa051400.90643792
70Epstein-Barr virus infection_Homo sapiens_hsa051690.89873444
71FoxO signaling pathway_Homo sapiens_hsa040680.89760771
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89458590
73Fatty acid elongation_Homo sapiens_hsa000620.85592917
74Type II diabetes mellitus_Homo sapiens_hsa049300.84785692
75p53 signaling pathway_Homo sapiens_hsa041150.83764860
76Calcium signaling pathway_Homo sapiens_hsa040200.83480559
77Dilated cardiomyopathy_Homo sapiens_hsa054140.82672374
78Thyroid cancer_Homo sapiens_hsa052160.82483447
79Pancreatic cancer_Homo sapiens_hsa052120.81708213
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80303449
81MAPK signaling pathway_Homo sapiens_hsa040100.80197031
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79992201
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79910625
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79639576
85Collecting duct acid secretion_Homo sapiens_hsa049660.79638375
86Measles_Homo sapiens_hsa051620.78042511
87Gap junction_Homo sapiens_hsa045400.76468441
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75240798
89Ovarian steroidogenesis_Homo sapiens_hsa049130.74913911
90Viral carcinogenesis_Homo sapiens_hsa052030.73907795
91Notch signaling pathway_Homo sapiens_hsa043300.73225225
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73166804
93Olfactory transduction_Homo sapiens_hsa047400.72982999
94Lysine degradation_Homo sapiens_hsa003100.72047032
95Shigellosis_Homo sapiens_hsa051310.71717978
96cAMP signaling pathway_Homo sapiens_hsa040240.70240147
97Biosynthesis of amino acids_Homo sapiens_hsa012300.69926064
98Prolactin signaling pathway_Homo sapiens_hsa049170.69412763
99HTLV-I infection_Homo sapiens_hsa051660.68929173
100Acute myeloid leukemia_Homo sapiens_hsa052210.68546196
101Gastric acid secretion_Homo sapiens_hsa049710.68289891
102Proteoglycans in cancer_Homo sapiens_hsa052050.67243916
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66094515
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65852032
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65261434
106Legionellosis_Homo sapiens_hsa051340.64901863
107Dorso-ventral axis formation_Homo sapiens_hsa043200.63883922
108Long-term depression_Homo sapiens_hsa047300.63861916
109Ether lipid metabolism_Homo sapiens_hsa005650.63381987
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63222453
111Antigen processing and presentation_Homo sapiens_hsa046120.62976947
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62902960
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62892875
114Pathways in cancer_Homo sapiens_hsa052000.62499531
115Arachidonic acid metabolism_Homo sapiens_hsa005900.62466703
116HIF-1 signaling pathway_Homo sapiens_hsa040660.62122913
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61875756
118Salivary secretion_Homo sapiens_hsa049700.61693655
119Fatty acid biosynthesis_Homo sapiens_hsa000610.61056183
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60833206
121Viral myocarditis_Homo sapiens_hsa054160.57798243
122Pyruvate metabolism_Homo sapiens_hsa006200.57793829
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57775465
124Regulation of autophagy_Homo sapiens_hsa041400.57616803
125One carbon pool by folate_Homo sapiens_hsa006700.55097816
126Estrogen signaling pathway_Homo sapiens_hsa049150.54581575
127Carbon metabolism_Homo sapiens_hsa012000.54443275
128Influenza A_Homo sapiens_hsa051640.54249768
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54098289
130Oxytocin signaling pathway_Homo sapiens_hsa049210.53857443
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.52477763
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51103931
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51101848
134Proteasome_Homo sapiens_hsa030500.50224901
135Rap1 signaling pathway_Homo sapiens_hsa040150.50032281
136Small cell lung cancer_Homo sapiens_hsa052220.49997576
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49447930
138Pentose phosphate pathway_Homo sapiens_hsa000300.48965324
139RNA transport_Homo sapiens_hsa030130.48231826
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47957581
141Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46201728
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46067983
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45778510
144Central carbon metabolism in cancer_Homo sapiens_hsa052300.45085842
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44511997
146Spliceosome_Homo sapiens_hsa030400.44233373
147TGF-beta signaling pathway_Homo sapiens_hsa043500.43578160
148Tight junction_Homo sapiens_hsa045300.43423779
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42623049
150Fanconi anemia pathway_Homo sapiens_hsa034600.42275645
151Chemokine signaling pathway_Homo sapiens_hsa040620.41164639
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40976767
153African trypanosomiasis_Homo sapiens_hsa051430.40842850
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.40558358
155MicroRNAs in cancer_Homo sapiens_hsa052060.39148211
156Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38720842
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.37995286
158Propanoate metabolism_Homo sapiens_hsa006400.37316673
159Rheumatoid arthritis_Homo sapiens_hsa053230.36949350
160Vitamin digestion and absorption_Homo sapiens_hsa049770.36395456
161Long-term potentiation_Homo sapiens_hsa047200.35496869
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35218485
163Inositol phosphate metabolism_Homo sapiens_hsa005620.35065579
164Renin secretion_Homo sapiens_hsa049240.34952163
165Non-small cell lung cancer_Homo sapiens_hsa052230.33729926
166Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30744276
167Huntingtons disease_Homo sapiens_hsa050160.30503627

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