TFCP2L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)9.28994355
2hemidesmosome assembly (GO:0031581)7.04466418
3negative regulation of keratinocyte proliferation (GO:0010839)6.51995160
4establishment of skin barrier (GO:0061436)6.50061138
5regulation of water loss via skin (GO:0033561)6.28115237
6multicellular organismal water homeostasis (GO:0050891)6.14798922
7excretion (GO:0007588)5.42254408
8regulation of posttranscriptional gene silencing (GO:0060147)5.30495582
9regulation of gene silencing by miRNA (GO:0060964)5.30495582
10regulation of gene silencing by RNA (GO:0060966)5.30495582
11keratinocyte proliferation (GO:0043616)5.24946497
12water homeostasis (GO:0030104)5.15068788
13keratinization (GO:0031424)4.96418757
14nuclear pore organization (GO:0006999)4.78246971
15regulation of helicase activity (GO:0051095)4.69426655
16anterior/posterior axis specification, embryo (GO:0008595)4.54983334
17somatic diversification of immune receptors via somatic mutation (GO:0002566)4.47042358
18somatic hypermutation of immunoglobulin genes (GO:0016446)4.47042358
19nucleobase biosynthetic process (GO:0046112)4.45524857
20nuclear pore complex assembly (GO:0051292)4.44340367
21intestinal epithelial cell development (GO:0060576)4.39091436
22purine nucleobase biosynthetic process (GO:0009113)4.36411024
23surfactant homeostasis (GO:0043129)4.36289394
24DNA replication-dependent nucleosome organization (GO:0034723)4.33072298
25DNA replication-dependent nucleosome assembly (GO:0006335)4.33072298
26keratinocyte differentiation (GO:0030216)4.14384133
27diterpenoid biosynthetic process (GO:0016102)4.08360441
28intermediate filament organization (GO:0045109)4.06716674
29regulation of keratinocyte proliferation (GO:0010837)4.01329291
30IMP biosynthetic process (GO:0006188)4.00355468
31mitotic metaphase plate congression (GO:0007080)3.92048191
32ventricular cardiac muscle cell action potential (GO:0086005)3.89178627
33DNA replication initiation (GO:0006270)3.87385695
34protein localization to kinetochore (GO:0034501)3.86751593
35folic acid metabolic process (GO:0046655)3.86707677
36positive regulation of SMAD protein import into nucleus (GO:0060391)3.82974233
37chemical homeostasis within a tissue (GO:0048875)3.82599402
38formation of translation preinitiation complex (GO:0001731)3.78867126
39folic acid-containing compound biosynthetic process (GO:0009396)3.74308009
40calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.74291360
41ribosome assembly (GO:0042255)3.73947596
42DNA replication checkpoint (GO:0000076)3.65999419
43keratinocyte development (GO:0003334)3.65812184
44mitotic nuclear envelope disassembly (GO:0007077)3.65408037
45epidermal cell differentiation (GO:0009913)3.64225159
46positive regulation of epidermal cell differentiation (GO:0045606)3.63128509
47regulation of keratinocyte differentiation (GO:0045616)3.62748164
48regulation of cholesterol homeostasis (GO:2000188)3.60819386
49histone H4-K12 acetylation (GO:0043983)3.59681044
50* determination of adult lifespan (GO:0008340)3.59086827
51regulation of histone H3-K9 methylation (GO:0051570)3.57539535
52interferon-gamma secretion (GO:0072643)3.52758771
53negative regulation of histone methylation (GO:0031061)3.48950232
54apical protein localization (GO:0045176)3.48612291
55epithelial cell-cell adhesion (GO:0090136)3.44590440
56epidermis development (GO:0008544)3.44588154
57ribosome biogenesis (GO:0042254)3.43480311
58O-glycan processing (GO:0016266)3.43037896
59pore complex assembly (GO:0046931)3.41440864
60positive regulation of keratinocyte differentiation (GO:0045618)3.39447570
61polyol transport (GO:0015791)3.39390816
62sulfate transmembrane transport (GO:1902358)3.39143511
63response to mercury ion (GO:0046689)3.38496973
64protein K6-linked ubiquitination (GO:0085020)3.38284729
65regulation of nuclear cell cycle DNA replication (GO:0033262)3.37188423
66nuclear envelope disassembly (GO:0051081)3.36740977
67membrane disassembly (GO:0030397)3.36740977
68regulation of hippo signaling (GO:0035330)3.35949490
69paraxial mesoderm development (GO:0048339)3.35597229
70hypotonic response (GO:0006971)3.35346340
71IMP metabolic process (GO:0046040)3.34566567
72molting cycle (GO:0042303)3.34551191
73hair cycle (GO:0042633)3.34551191
74mitotic sister chromatid segregation (GO:0000070)3.31692152
75DNA strand elongation involved in DNA replication (GO:0006271)3.31019206
76tight junction assembly (GO:0070830)3.28718008
77cytoskeletal anchoring at plasma membrane (GO:0007016)3.28069510
78metaphase plate congression (GO:0051310)3.27467146
79DNA unwinding involved in DNA replication (GO:0006268)3.20562427
80positive regulation of chromosome segregation (GO:0051984)3.19239882
81regulation of telomere maintenance via telomerase (GO:0032210)3.16248117
82regulation of gene silencing (GO:0060968)3.16052609
83DNA geometric change (GO:0032392)3.15920304
84DNA duplex unwinding (GO:0032508)3.14720135
85trophectodermal cell differentiation (GO:0001829)3.14501916
86regulation of SMAD protein import into nucleus (GO:0060390)3.13781528
87negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.13586026
88DNA strand elongation (GO:0022616)3.13579965
89renal absorption (GO:0070293)3.11611935
90negative regulation of androgen receptor signaling pathway (GO:0060766)3.11537045
91heterochromatin organization (GO:0070828)3.09224079
92pyrimidine-containing compound transmembrane transport (GO:0072531)3.05935506
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03991912
94chaperone-mediated protein complex assembly (GO:0051131)3.03090031
95pre-miRNA processing (GO:0031054)3.02529914
96cell-cell junction assembly (GO:0007043)3.00226032
97regulation of translational fidelity (GO:0006450)3.00165666
98sulfate transport (GO:0008272)2.99801263
99protein localization to chromosome, centromeric region (GO:0071459)2.98822665
100regulation of spindle organization (GO:0090224)2.98663332
101asymmetric protein localization (GO:0008105)2.98345268
102establishment of apical/basal cell polarity (GO:0035089)2.96688385
103establishment of protein localization to mitochondrial membrane (GO:0090151)2.96445513
104regulation of translation in response to stress (GO:0043555)2.96156834
105protein autoprocessing (GO:0016540)2.95387088
106spindle assembly involved in mitosis (GO:0090307)2.95261059
107peptide cross-linking (GO:0018149)2.93561158
108regulation of transforming growth factor beta2 production (GO:0032909)2.91845976
109establishment of tissue polarity (GO:0007164)2.90632801
110establishment of planar polarity (GO:0001736)2.90632801
111regulation of centrosome cycle (GO:0046605)2.89733317
112glycine metabolic process (GO:0006544)2.88919956
113sister chromatid segregation (GO:0000819)2.88310815
114gap junction assembly (GO:0016264)2.87186293
115regulation of sister chromatid cohesion (GO:0007063)2.86692228
116negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.86663691
117maturation of SSU-rRNA (GO:0030490)2.86579414
118response to thyroid hormone (GO:0097066)2.85900484
119cell-substrate junction assembly (GO:0007044)2.85889041
120rRNA modification (GO:0000154)2.85607574
121notochord development (GO:0030903)2.85224822
122telomere maintenance via semi-conservative replication (GO:0032201)2.84781637
123regulation of epidermal cell differentiation (GO:0045604)2.83209101
124regulation of cardioblast differentiation (GO:0051890)2.83103158
125positive regulation of epidermis development (GO:0045684)2.82013675
126phosphate ion transport (GO:0006817)2.81506175
127ribonucleoprotein complex biogenesis (GO:0022613)2.81262794
128regulation of mitotic spindle organization (GO:0060236)2.80970088
129negative regulation of myotube differentiation (GO:0010832)2.80491879
130sphingomyelin metabolic process (GO:0006684)2.80311782
131histone arginine methylation (GO:0034969)2.80006965
132regulation of transforming growth factor beta1 production (GO:0032908)2.79738250
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.78816709
134metanephric nephron tubule development (GO:0072234)2.78257361
135metanephric tubule development (GO:0072170)2.78257361
136regulation of G0 to G1 transition (GO:0070316)2.78009765
137one-carbon compound transport (GO:0019755)2.77631925
138sodium ion homeostasis (GO:0055078)2.77514429
139regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.76738265
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73302064
141establishment of chromosome localization (GO:0051303)2.73154076
142mismatch repair (GO:0006298)2.73106919
143replication fork processing (GO:0031297)2.71367229
144blastocyst development (GO:0001824)2.70906318
145chromatin assembly (GO:0031497)2.70724924
146cellular response to thyroid hormone stimulus (GO:0097067)2.70192165
147regulation of translational termination (GO:0006449)2.69990974
148morphogenesis of embryonic epithelium (GO:0016331)2.69523999
149histone H2A monoubiquitination (GO:0035518)2.69342595
150mitotic sister chromatid cohesion (GO:0007064)2.69128448
151regulation of histone H3-K27 methylation (GO:0061085)2.68527721
152negative regulation of translational initiation (GO:0045947)2.68229354
153regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.67857613
154endosome organization (GO:0007032)2.65975811
155regulation of chromosome segregation (GO:0051983)2.65690575
156folic acid-containing compound metabolic process (GO:0006760)2.65676718
157microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.65525697
158inner cell mass cell proliferation (GO:0001833)2.65296902
159regulation of double-strand break repair via homologous recombination (GO:0010569)2.64542165
160metanephric nephron epithelium development (GO:0072243)2.64522212
161columnar/cuboidal epithelial cell development (GO:0002066)2.64490791
162regulation of pH (GO:0006885)2.64449708
163positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64174177
164positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64174177
165positive regulation of mitotic sister chromatid separation (GO:1901970)2.64174177
166histone H4-K8 acetylation (GO:0043982)2.62067469
167histone H4-K5 acetylation (GO:0043981)2.62067469
168negative regulation of gene silencing (GO:0060969)2.61942629
169regulation of epidermis development (GO:0045682)2.61539963
170chromatin remodeling at centromere (GO:0031055)2.61479669
171embryonic process involved in female pregnancy (GO:0060136)2.61351437
172renal filtration (GO:0097205)2.60568900
173polarized epithelial cell differentiation (GO:0030859)2.59901226
174skin morphogenesis (GO:0043589)2.59168313
175receptor recycling (GO:0001881)2.57269669
176collecting duct development (GO:0072044)2.56683544
177regulation of protein localization to cell surface (GO:2000008)2.55648753
178regulation of heart rate by cardiac conduction (GO:0086091)2.55615253
179maintenance of gastrointestinal epithelium (GO:0030277)2.52448320
180branching involved in mammary gland duct morphogenesis (GO:0060444)2.51131824
181positive regulation of catenin import into nucleus (GO:0035413)2.50463165
182actin filament depolymerization (GO:0030042)2.49274492
183intermediate filament cytoskeleton organization (GO:0045104)2.48391332
184cell volume homeostasis (GO:0006884)2.47713428
185regulation of clathrin-mediated endocytosis (GO:2000369)2.46321412
186metanephric epithelium development (GO:0072207)2.45335692
187positive regulation of Cdc42 GTPase activity (GO:0043089)2.43263325
188regulation of p38MAPK cascade (GO:1900744)2.41442604
189thyroid hormone generation (GO:0006590)2.40917902
190monovalent inorganic cation homeostasis (GO:0055067)2.39426287
191early endosome to late endosome transport (GO:0045022)2.39407394
192positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.39283261
193glomerular filtration (GO:0003094)2.39144835
194transcytosis (GO:0045056)2.37962560
195positive regulation of respiratory burst (GO:0060267)2.37523707
196desmosome organization (GO:0002934)10.6911538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.57199247
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.58810275
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.28118156
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.61158952
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.61158952
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.61158952
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.44467895
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.44467264
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.35155285
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.23788877
11CDX2_20551321_ChIP-Seq_CACO-2_Human3.20084267
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.05700588
13ESR2_21235772_ChIP-Seq_MCF-7_Human3.03284200
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95413723
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.95084040
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.93146764
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.86750313
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.84745184
19FOXO3_23340844_ChIP-Seq_DLD1_Human2.73727641
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71520803
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.69083508
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.60887434
23STAT3_1855785_ChIP-Seq_MESCs_Mouse2.58089346
24ZNF217_24962896_ChIP-Seq_MCF-7_Human2.54484280
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.46964649
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.46964649
27SOX9_24532713_ChIP-Seq_HFSC_Mouse2.42515859
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42016950
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41550561
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.38413112
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35253539
32TCF3_18692474_ChIP-Seq_MESCs_Mouse2.33843356
33P63_26484246_Chip-Seq_KERATINOCYTES_Human2.30482326
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.27519794
35* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.17330792
36GATA6_25053715_ChIP-Seq_YYC3_Human2.15488339
37* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.14967708
38* GATA4_25053715_ChIP-Seq_YYC3_Human2.14333183
39MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14134002
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.14045747
41SOX2_18555785_ChIP-Seq_MESCs_Mouse2.12829084
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12713043
43ESR1_20079471_ChIP-ChIP_T-47D_Human2.11438729
44* SOX2_20726797_ChIP-Seq_SW620_Human2.09400667
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08896019
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.05682486
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.05299335
48NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05090505
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.04845104
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04673387
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03736287
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00534283
53AHR_22903824_ChIP-Seq_MCF-7_Human1.98166344
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97773082
55AR_21909140_ChIP-Seq_LNCAP_Human1.97449049
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96166920
57ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.96069583
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.93604705
59KLF5_25053715_ChIP-Seq_YYC3_Human1.90543726
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85884832
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.81090986
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80948361
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80129926
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79139714
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75358038
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72188018
67* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.71808664
68SOX2_18692474_ChIP-Seq_MEFs_Mouse1.71615752
69NANOG_18692474_ChIP-Seq_MEFs_Mouse1.70769011
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.70563966
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.70523585
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.70107308
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67383013
74GATA3_24758297_ChIP-Seq_MCF-7_Human1.66436510
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.66275944
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.65984220
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.65127845
78TP63_23658742_ChIP-Seq_EP156T_Human1.64818930
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63621178
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63330550
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.63002573
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61645982
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61439797
84RACK7_27058665_Chip-Seq_MCF-7_Human1.59586161
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58949734
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58699820
87SOX2_18692474_ChIP-Seq_MESCs_Mouse1.58679952
88POU5F1_16518401_ChIP-PET_MESCs_Mouse1.57953741
89NANOG_18692474_ChIP-Seq_MESCs_Mouse1.56012299
90* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.55811465
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.50400415
92XRN2_22483619_ChIP-Seq_HELA_Human1.48621942
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.46287845
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44848384
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.42383459
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.42231654
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40061702
98* TCF4_18268006_ChIP-ChIP_LS174T_Human1.39672682
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39297834
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39161703
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.37359113
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.36948105
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.36022799
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34825243
105POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34134653
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33343453
107CLOCK_20551151_ChIP-Seq_293T_Human1.30534623
108KAP1_27257070_Chip-Seq_ESCs_Mouse1.29215651
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28103243
110ATF3_27146783_Chip-Seq_COLON_Human1.28024220
111TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.26593718
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26557189
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24966325
114TP63_22573176_ChIP-Seq_HFKS_Human1.24687020
115LXR_22158963_ChIP-Seq_LIVER_Mouse1.24598889
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.24068238
117GABP_17652178_ChIP-ChIP_JURKAT_Human1.23165813
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22730832
119PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21100911
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21011573
121FOXA2_19822575_ChIP-Seq_HepG2_Human1.19917765
122NANOG_16518401_ChIP-PET_MESCs_Mouse1.17071540
123VDR_23849224_ChIP-Seq_CD4+_Human1.16897948
124ZNF263_19887448_ChIP-Seq_K562_Human1.16426526
125* FOXA1_25552417_ChIP-Seq_VCAP_Human1.12611374
126TBX20_22080862_ChIP-Seq_HEART_Mouse1.12134095
127TBX20_22328084_ChIP-Seq_HEART_Mouse1.12134095
128DCP1A_22483619_ChIP-Seq_HELA_Human1.12057431
129RXR_22158963_ChIP-Seq_LIVER_Mouse1.11201986
130TP63_17297297_ChIP-ChIP_HaCaT_Human1.10393432
131NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09362809
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08890264
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06830170
134POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06304596
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05682591
136KDM5A_27292631_Chip-Seq_BREAST_Human1.05009901
137TTF2_22483619_ChIP-Seq_HELA_Human1.04775713
138ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03054168
139TRIM28_21343339_ChIP-Seq_HEK293_Human1.02673861
140PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02366657
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02253607
142THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01690829
143CJUN_26792858_Chip-Seq_BT549_Human1.01530050
144YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00421308
145FOXP3_21729870_ChIP-Seq_TREG_Human0.99782730
146GABP_19822575_ChIP-Seq_HepG2_Human0.99764272
147SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99388966
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97880650
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96003606
150* CDX2_22108803_ChIP-Seq_LS180_Human0.94741361
151RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93537723
152TFEB_21752829_ChIP-Seq_HELA_Human0.93448912
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91037583
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89742818
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.88964431
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88298482
157ESR1_21235772_ChIP-Seq_MCF-7_Human0.87339548
158RXR_22108803_ChIP-Seq_LS180_Human0.86430955
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.86093846
160NANOG_16153702_ChIP-ChIP_HESCs_Human0.85640393
161SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85511956
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85290454
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84254070
164TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83968955
165* CHD1_26751641_Chip-Seq_LNCaP_Human0.83392643
166TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.82497500
167GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82357091
168IRF1_19129219_ChIP-ChIP_H3396_Human0.80760729
169TET1_21490601_ChIP-Seq_MESCs_Mouse0.79972161
170RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79645124
171TP63_19390658_ChIP-ChIP_HaCaT_Human0.79051880
172PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78854595
173UBF1/2_26484160_Chip-Seq_HMECs_Human0.78814308
174TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77369336
175DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76930302
176UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76501821
177SOX17_20123909_ChIP-Seq_XEN_Mouse0.76414729
178TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.76063858
179CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75703229
180SMC4_20622854_ChIP-Seq_HELA_Human0.75625223
181MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.74979396
182JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72683482
183PIAS1_25552417_ChIP-Seq_VCAP_Human0.72425485
184JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72304136
185TP53_16413492_ChIP-PET_HCT116_Human0.72201025
186EGR1_23403033_ChIP-Seq_LIVER_Mouse0.71594924
187KDM2B_26808549_Chip-Seq_K562_Human0.70570844
188Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70191216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.28558555
2MP0004957_abnormal_blastocyst_morpholog4.06547113
3MP0000566_synostosis3.91938774
4MP0003806_abnormal_nucleotide_metabolis3.91895300
5MP0003111_abnormal_nucleus_morphology3.71287153
6MP0008057_abnormal_DNA_replication3.50609636
7MP0010094_abnormal_chromosome_stability3.44065734
8MP0000383_abnormal_hair_follicle2.98762273
9MP0002098_abnormal_vibrissa_morphology2.96557312
10MP0000579_abnormal_nail_morphology2.94947553
11MP0010352_gastrointestinal_tract_polyps2.92282994
12MP0003077_abnormal_cell_cycle2.89399384
13MP0008058_abnormal_DNA_repair2.48427556
14MP0004885_abnormal_endolymph2.45289150
15MP0004264_abnormal_extraembryonic_tissu2.40578183
16MP0010234_abnormal_vibrissa_follicle2.32647981
17MP0002653_abnormal_ependyma_morphology2.32011511
18MP0005275_abnormal_skin_tensile2.31629162
19MP0001216_abnormal_epidermal_layer2.26227476
20MP0001730_embryonic_growth_arrest2.16964657
21MP0005409_darkened_coat_color2.13866724
22MP0004133_heterotaxia2.12749166
23MP0003941_abnormal_skin_development2.12515907
24MP0003718_maternal_effect2.11503004
25MP0001765_abnormal_ion_homeostasis2.11050027
26MP0008932_abnormal_embryonic_tissue2.05310566
27MP0000350_abnormal_cell_proliferation1.96888571
28MP0000377_abnormal_hair_follicle1.96087589
29MP0003786_premature_aging1.93146864
30MP0002060_abnormal_skin_morphology1.86978034
31MP0001672_abnormal_embryogenesis/_devel1.83702632
32MP0005380_embryogenesis_phenotype1.83702632
33MP0009780_abnormal_chondrocyte_physiolo1.80564431
34MP0002084_abnormal_developmental_patter1.80511946
35MP0003878_abnormal_ear_physiology1.79809046
36MP0005377_hearing/vestibular/ear_phenot1.79809046
37MP0002085_abnormal_embryonic_tissue1.77578151
38MP0004043_abnormal_pH_regulation1.77539883
39MP0003890_abnormal_embryonic-extraembry1.76807040
40MP0004019_abnormal_vitamin_homeostasis1.74890891
41MP0002086_abnormal_extraembryonic_tissu1.71264279
42MP0003283_abnormal_digestive_organ1.65735099
43MP0003119_abnormal_digestive_system1.64737916
44MP0000678_abnormal_parathyroid_gland1.60957340
45MP0010771_integument_phenotype1.60654960
46MP0001697_abnormal_embryo_size1.58814084
47MP0001293_anophthalmia1.56253025
48MP0010307_abnormal_tumor_latency1.54069556
49MP0003984_embryonic_growth_retardation1.53231055
50MP0000537_abnormal_urethra_morphology1.53001806
51MP0002088_abnormal_embryonic_growth/wei1.51058233
52MP0003195_calcinosis1.50799905
53MP0003566_abnormal_cell_adhesion1.50100748
54MP0010368_abnormal_lymphatic_system1.46981439
55MP0003136_yellow_coat_color1.45322649
56MP0003315_abnormal_perineum_morphology1.43172893
57MP0001849_ear_inflammation1.42991038
58MP0005670_abnormal_white_adipose1.42274566
59MP0000490_abnormal_crypts_of1.41153470
60MP0002080_prenatal_lethality1.40285672
61MP0004197_abnormal_fetal_growth/weight/1.39982122
62MP0000647_abnormal_sebaceous_gland1.36055787
63MP0003705_abnormal_hypodermis_morpholog1.33833105
64MP0005636_abnormal_mineral_homeostasis1.31624232
65MP0008007_abnormal_cellular_replicative1.30505864
66MP0005367_renal/urinary_system_phenotyp1.30228743
67MP0000516_abnormal_urinary_system1.30228743
68MP0002796_impaired_skin_barrier1.26895566
69MP0005076_abnormal_cell_differentiation1.26481862
70MP0003186_abnormal_redox_activity1.26241054
71MP0001485_abnormal_pinna_reflex1.24139125
72MP0005332_abnormal_amino_acid1.18086852
73MP0003567_abnormal_fetal_cardiomyocyte1.16859523
74MP0000427_abnormal_hair_cycle1.16076663
75MP0003123_paternal_imprinting1.13376588
76MP0009643_abnormal_urine_homeostasis1.12045801
77MP0003045_fibrosis1.11444391
78MP0005666_abnormal_adipose_tissue1.10966523
79MP0002876_abnormal_thyroid_physiology1.09440728
80MP0005501_abnormal_skin_physiology1.08790736
81MP0008004_abnormal_stomach_pH1.08369342
82MP0001145_abnormal_male_reproductive1.08290576
83MP0005266_abnormal_metabolism1.08283083
84MP0004185_abnormal_adipocyte_glucose1.05350781
85MP0005395_other_phenotype1.05067029
86MP0002254_reproductive_system_inflammat1.02724622
87MP0001756_abnormal_urination1.01506005
88MP0003936_abnormal_reproductive_system1.01465148
89MP0008961_abnormal_basal_metabolism1.00006451
90MP0000477_abnormal_intestine_morphology0.99142272
91MP0002896_abnormal_bone_mineralization0.98427739
92MP0000313_abnormal_cell_death0.97717654
93MP0010030_abnormal_orbit_morphology0.97479933
94MP0005023_abnormal_wound_healing0.97158060
95MP0002168_other_aberrant_phenotype0.96707258
96MP0002210_abnormal_sex_determination0.96513136
97MP0009379_abnormal_foot_pigmentation0.94817439
98MP0000371_diluted_coat_color0.94518892
99MP0004947_skin_inflammation0.90868288
100MP0002111_abnormal_tail_morphology0.90593296
101MP0009931_abnormal_skin_appearance0.89773942
102MP0000367_abnormal_coat/_hair0.85628546
103MP0002136_abnormal_kidney_physiology0.84764000
104MP0005451_abnormal_body_composition0.84465361
105MP0009053_abnormal_anal_canal0.82882344
106MP0003943_abnormal_hepatobiliary_system0.82866892
107MP0005360_urolithiasis0.82652478
108MP0000462_abnormal_digestive_system0.80766693
109MP0004381_abnormal_hair_follicle0.80351183
110MP0005375_adipose_tissue_phenotype0.80195385
111MP0003183_abnormal_peptide_metabolism0.79938996
112MP0002277_abnormal_respiratory_mucosa0.79723500
113MP0006292_abnormal_olfactory_placode0.79639284
114MP0000627_abnormal_mammary_gland0.79252780
115MP0002019_abnormal_tumor_incidence0.78869526
116MP0001286_abnormal_eye_development0.78473377
117MP0003937_abnormal_limbs/digits/tail_de0.78416107
118MP0010678_abnormal_skin_adnexa0.76693584
119MP0000432_abnormal_head_morphology0.76541215
120MP0000653_abnormal_sex_gland0.76149673
121MP0002092_abnormal_eye_morphology0.76052677
122MP0003453_abnormal_keratinocyte_physiol0.74043802
123MP0001929_abnormal_gametogenesis0.73052892
124MP0001191_abnormal_skin_condition0.73030995
125MP0000762_abnormal_tongue_morphology0.71713499
126MP0000467_abnormal_esophagus_morphology0.71353546
127MP0004782_abnormal_surfactant_physiolog0.71159072
128MP0001664_abnormal_digestion0.70359037
129MP0005365_abnormal_bile_salt0.68551893
130MP0009703_decreased_birth_body0.68389679
131MP0000358_abnormal_cell_content/0.67951801
132MP0005621_abnormal_cell_physiology0.67085763
133MP0005384_cellular_phenotype0.66987053
134MP0000470_abnormal_stomach_morphology0.65895680
135MP0002697_abnormal_eye_size0.65228478
136MP0003252_abnormal_bile_duct0.64925367
137MP0003866_abnormal_defecation0.64223459
138MP0008877_abnormal_DNA_methylation0.64192714
139MP0001784_abnormal_fluid_regulation0.63024409
140MP0003191_abnormal_cellular_cholesterol0.62920320
141MP0002138_abnormal_hepatobiliary_system0.61294225
142MP0005389_reproductive_system_phenotype0.61236920
143MP0002269_muscular_atrophy0.61128890
144MP0003950_abnormal_plasma_membrane0.61024879
145MP0001346_abnormal_lacrimal_gland0.60761166
146MP0005257_abnormal_intraocular_pressure0.60443338
147MP0005085_abnormal_gallbladder_physiolo0.60084418
148MP0001851_eye_inflammation0.59568555
149MP0001873_stomach_inflammation0.58835227
150MP0002009_preneoplasia0.57941749
151MP0000003_abnormal_adipose_tissue0.57801839
152MP0003091_abnormal_cell_migration0.54909767
153MP0002234_abnormal_pharynx_morphology0.54125386
154MP0004233_abnormal_muscle_weight0.53921509

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of renin-angiotensin system (HP:0000847)6.23816662
2Right ventricular cardiomyopathy (HP:0011663)5.81813546
3Ependymoma (HP:0002888)5.05916237
4Abnormality of cochlea (HP:0000375)4.78569579
5Lip pit (HP:0100267)4.33333260
6Abnormality of the labia minora (HP:0012880)4.19853293
7Renal salt wasting (HP:0000127)4.16757934
8Abnormality of nail color (HP:0100643)3.97200791
9Abnormality of magnesium homeostasis (HP:0004921)3.96131832
10Plantar hyperkeratosis (HP:0007556)3.95582285
11Breast hypoplasia (HP:0003187)3.94730562
12Pili torti (HP:0003777)3.81665097
13Flat acetabular roof (HP:0003180)3.77922765
14Hyperactive renin-angiotensin system (HP:0000841)3.73143632
15Abnormality of chloride homeostasis (HP:0011422)3.71639069
16Onycholysis (HP:0001806)3.68590297
17Hypokalemia (HP:0002900)3.60554316
18Palmoplantar hyperkeratosis (HP:0000972)3.58910279
19Decreased circulating renin level (HP:0003351)3.57105931
20Absent radius (HP:0003974)3.54722504
21Aplasia/hypoplasia of the humerus (HP:0006507)3.50772064
22Abnormality of the astrocytes (HP:0100707)3.48819094
23Astrocytoma (HP:0009592)3.48819094
24Abnormality of potassium homeostasis (HP:0011042)3.46487415
25Birth length less than 3rd percentile (HP:0003561)3.42241624
26Fragile nails (HP:0001808)3.38673720
27Short humerus (HP:0005792)3.38197666
28Palmar hyperkeratosis (HP:0010765)3.36390488
29Hyperkalemia (HP:0002153)3.35684187
30Metabolic alkalosis (HP:0200114)3.34560357
31Aplasia involving forearm bones (HP:0009822)3.32885563
32Absent forearm bone (HP:0003953)3.32885563
33Hypokalemic alkalosis (HP:0001949)3.29085967
34Chronic bronchitis (HP:0004469)3.28121029
35Carpal bone hypoplasia (HP:0001498)3.26854937
36Milia (HP:0001056)3.25785425
37Hyperglycinuria (HP:0003108)3.17478264
38Morphological abnormality of the inner ear (HP:0011390)3.14817845
39Selective tooth agenesis (HP:0001592)3.14555689
40Woolly hair (HP:0002224)3.13685467
41Chromosomal breakage induced by crosslinking agents (HP:0003221)3.11953421
42Dehydration (HP:0001944)3.11596274
43Rhabdomyosarcoma (HP:0002859)3.09226076
44Shawl scrotum (HP:0000049)3.06387349
45Neonatal short-limb short stature (HP:0008921)3.03894809
46Neoplasm of the oral cavity (HP:0100649)3.00979089
47Glioma (HP:0009733)2.98663429
48Alopecia of scalp (HP:0002293)2.98099304
49Medulloblastoma (HP:0002885)2.97650320
50Amelogenesis imperfecta (HP:0000705)2.96762497
51Impulsivity (HP:0100710)2.96593788
52Adrenal overactivity (HP:0002717)2.96083426
53Chromsome breakage (HP:0040012)2.94974086
54Thick nail (HP:0001805)2.93643570
55Hyponatremia (HP:0002902)2.93194391
56Agnosia (HP:0010524)2.92929799
57Hypoplastic labia majora (HP:0000059)2.89640320
58Biliary tract neoplasm (HP:0100574)2.78855423
59Hypotrichosis (HP:0001006)2.76504975
60Abnormal hair laboratory examination (HP:0003328)2.75844234
61Hyperaldosteronism (HP:0000859)2.72907180
62Gout (HP:0001997)2.70129116
63Abnormality of the salivary glands (HP:0010286)2.68134862
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.67818577
65Rectovaginal fistula (HP:0000143)2.63089948
66Rectal fistula (HP:0100590)2.63089948
67Colon cancer (HP:0003003)2.61383388
68Popliteal pterygium (HP:0009756)2.58647014
69Abnormality of the labia majora (HP:0012881)2.55795020
70Bilateral sensorineural hearing impairment (HP:0008619)2.54305392
71Supernumerary spleens (HP:0009799)2.51091014
72Abnormality of the dental root (HP:0006486)2.51040093
73Taurodontia (HP:0000679)2.51040093
74Abnormality of permanent molar morphology (HP:0011071)2.51040093
75Spinal muscular atrophy (HP:0007269)2.50885186
76Patellar aplasia (HP:0006443)2.49236945
77Hypoplasia of dental enamel (HP:0006297)2.48403235
78Malnutrition (HP:0004395)2.46837241
79Rough bone trabeculation (HP:0100670)2.46620342
80Polyuria (HP:0000103)2.43683756
81Reticulocytopenia (HP:0001896)2.42314025
82Stenosis of the external auditory canal (HP:0000402)2.41522379
83Hyperglycinemia (HP:0002154)2.41499369
84Advanced eruption of teeth (HP:0006288)2.41334633
85Neoplasm of striated muscle (HP:0009728)2.40497960
86Abnormality of sodium homeostasis (HP:0010931)2.38098036
87Increased circulating renin level (HP:0000848)2.35955352
88Abnormality of chromosome stability (HP:0003220)2.35508487
89Vaginal fistula (HP:0004320)2.34778615
90Abnormality of molar (HP:0011077)2.33914837
91Abnormality of molar morphology (HP:0011070)2.33914837
92Metaphyseal cupping (HP:0003021)2.33885411
93Absent thumb (HP:0009777)2.33830172
94Vertebral clefting (HP:0008428)2.32591517
95Rib fusion (HP:0000902)2.32341606
96Abnormal drinking behavior (HP:0030082)2.31703547
97Polydipsia (HP:0001959)2.31703547
98Abnormality of glycine metabolism (HP:0010895)2.30158534
99Abnormality of serine family amino acid metabolism (HP:0010894)2.30158534
100Nail dystrophy (HP:0008404)2.29061745
101Aplasia/Hypoplasia of the patella (HP:0006498)2.28974594
102Esophageal atresia (HP:0002032)2.28183722
103Renal tubular acidosis (HP:0001947)2.28070983
104Abnormality of the dental pulp (HP:0006479)2.26338418
105Intestinal fistula (HP:0100819)2.23426179
106Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23058346
107Abnormality of the preputium (HP:0100587)2.22202980
108Meckel diverticulum (HP:0002245)2.21911481
109Abnormal urine output (HP:0012590)2.20437791
110Abnormality of renal excretion (HP:0011036)2.19692907
111Proximal tubulopathy (HP:0000114)2.16917362
112Abnormality of the ileum (HP:0001549)2.16505394
113Abnormal biliary tract morphology (HP:0012440)2.15643147
114Hypercalciuria (HP:0002150)2.14687310
115Abnormality of pyrimidine metabolism (HP:0004353)2.14581836
116Aplasia/Hypoplasia of the uvula (HP:0010293)2.13258733
117Flattened epiphyses (HP:0003071)2.12309968
118Natal tooth (HP:0000695)2.12142592
119Hypomagnesemia (HP:0002917)2.11886190
120Flat capital femoral epiphysis (HP:0003370)2.11234702
121Sparse scalp hair (HP:0002209)2.10015569
122Abnormality of abdominal situs (HP:0011620)2.09238030
123Abdominal situs inversus (HP:0003363)2.09238030
124Alkalosis (HP:0001948)2.08275726
125Spastic diplegia (HP:0001264)2.08022934
126Abnormal number of incisors (HP:0011064)2.07977474
127Anal stenosis (HP:0002025)2.06424689
128Atrophic scars (HP:0001075)2.04946215
129Missing ribs (HP:0000921)2.03842479
130Abnormal vertebral ossification (HP:0100569)2.03502871
131Fused cervical vertebrae (HP:0002949)2.02914226
132Short 1st metacarpal (HP:0010034)1.99767654
133Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.99767654
134Cerebral hypomyelination (HP:0006808)1.99419556
135Premature ovarian failure (HP:0008209)1.98888191
136Absent eyelashes (HP:0000561)1.97683332
137Abnormality of the fingertips (HP:0001211)1.97578780
138Abnormal trabecular bone morphology (HP:0100671)1.95336822
139Abnormality of the distal phalanx of the thumb (HP:0009617)1.93962254
140Multiple enchondromatosis (HP:0005701)1.91375659
141Tetany (HP:0001281)1.89797492
142Congenital ichthyosiform erythroderma (HP:0007431)1.89770706
143Tongue fasciculations (HP:0001308)1.89597082
144Oral leukoplakia (HP:0002745)1.88491185
145Focal segmental glomerulosclerosis (HP:0000097)1.88317650
146High anterior hairline (HP:0009890)1.87645060
147Abnormality of the 1st metacarpal (HP:0010009)1.86851635
148Delayed puberty (HP:0000823)1.86503850
149Abnormal cartilage morphology (HP:0002763)1.86064091
150Increased purine levels (HP:0004368)1.84146316
151Hyperuricemia (HP:0002149)1.84146316
152Small intestinal stenosis (HP:0012848)1.83842804
153Duodenal stenosis (HP:0100867)1.83842804
154Horseshoe kidney (HP:0000085)1.83628434
155Ovarian neoplasm (HP:0100615)1.83349336
156Villous atrophy (HP:0011473)1.82978582
157Abnormality of small intestinal villus morphology (HP:0011472)1.82978582
158Abnormality of the anterior horn cell (HP:0006802)1.82861679
159Degeneration of anterior horn cells (HP:0002398)1.82861679
160Ridged nail (HP:0001807)1.81786154
161Gastrointestinal carcinoma (HP:0002672)1.81782462
162Curly hair (HP:0002212)1.76386038
163Nephrocalcinosis (HP:0000121)1.73516854
164Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.73032442
165Vertebral hypoplasia (HP:0008417)1.73032442
166Hypotension (HP:0002615)1.72779699
167Abnormal blistering of the skin (HP:0008066)1.72408199
168Sparse eyelashes (HP:0000653)1.71452568
169Abnormality of the distal phalanges of the toes (HP:0010182)1.70553083
170Oligodontia (HP:0000677)1.70456798
171Delayed epiphyseal ossification (HP:0002663)1.68470882
172Tubular atrophy (HP:0000092)1.67731198
173Increased IgE level (HP:0003212)1.64978185
174Hoarse voice (HP:0001609)1.64707882
175Neonatal death (HP:0003811)1.62125660
176Abnormal tarsal ossification (HP:0008369)1.60263852
177Chondrocalcinosis (HP:0000934)1.59890065
178Visceral angiomatosis (HP:0100761)1.59324771
179Abnormality of the gastric mucosa (HP:0004295)1.59053248
180Glomerulosclerosis (HP:0000096)1.57276312
181Abnormality of Sharpey fibers (HP:0100685)1.55652017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.43183492
2WEE14.36016437
3AKT33.93835838
4NEK13.75166086
5CDK123.46498586
6TTK3.11336554
7BUB12.98263368
8STK242.94444986
9MAP3K22.91230088
10PNCK2.52187987
11TSSK62.47772769
12PBK2.42729004
13RPS6KB22.27425442
14RIPK12.16587493
15WNK31.99524857
16CDC71.95981946
17PIK3CA1.92915849
18SRPK11.92858940
19STK38L1.86884856
20PLK11.84578872
21NEK21.84244723
22ZAK1.76045734
23MST41.68969788
24CDK71.62834314
25TLK11.59894042
26CHEK21.45645908
27PRKCI1.44352268
28OXSR11.44102785
29PDK21.41267176
30FRK1.40632990
31MET1.36729969
32PDK41.33503083
33PDK31.33503083
34PAK41.31427124
35EIF2AK11.31406780
36AURKB1.30882849
37PLK31.30706853
38MAP3K31.28718360
39DYRK31.24798465
40ATR1.19328502
41CAMK1G1.19318293
42LMTK21.18900579
43LATS11.18195885
44MAPK151.16872618
45BRD41.15459225
46MAP3K81.15403521
47SGK21.14198047
48PTK21.14101741
49AURKA1.13377643
50CAMK1D1.12881701
51SGK31.08718882
52TRPM71.07996695
53CHEK11.07012442
54WNK41.04156999
55CDK40.99414359
56WNK10.99022125
57ALK0.96954067
58MAP3K60.96709388
59PASK0.96139029
60BCKDK0.95407136
61MAPKAPK30.94795929
62SMG10.92050184
63STK100.91700732
64LATS20.91506194
65SGK4940.87046046
66SGK2230.87046046
67PIM10.86976467
68BRSK20.86950394
69TESK20.81791729
70CDK20.80098955
71PHKG10.79810867
72PHKG20.79810867
73PLK40.78370424
74ATM0.78001068
75VRK10.77568939
76PDGFRB0.77508770
77STK40.77117659
78SCYL20.73751846
79ACVR1B0.73650609
80NME10.71697398
81ICK0.71667300
82PRKAA20.71199708
83MTOR0.71153076
84CDC42BPA0.71121115
85NLK0.67281896
86TRIB30.67263309
87MAP3K70.66630300
88EIF2AK30.65104354
89CSNK1E0.64955655
90TGFBR10.63211235
91STK390.61350928
92PAK10.61012556
93MELK0.60948971
94FER0.60562477
95NEK60.58090161
96STK30.57862637
97NME20.57553288
98CSNK2A20.57316712
99PDGFRA0.57237522
100AKT20.55845650
101DDR20.55645398
102STK380.55635641
103DMPK0.55028290
104CDK60.54240170
105MAP2K20.53783006
106CSNK1D0.52256919
107CDK10.51710698
108EPHB20.51246523
109MKNK20.50541464
110DYRK20.48657356
111EEF2K0.47795787
112MATK0.46195290
113CSNK2A10.45705411
114MKNK10.44443295
115MAP3K90.43774264
116BMPR1B0.41439719
117SGK10.40426080
118ERBB40.39431822
119ERBB20.38983721
120STK160.38816733
121TYRO30.36633704
122ABL20.35814377
123YES10.35231563
124BRAF0.34716589
125PRKG20.34633620
126PRKAA10.34063070
127GSK3A0.33496574
128MAP3K10.33140736
129MARK20.32811440
130EPHB10.32078347
131MST1R0.30580853
132TESK10.30363452
133FLT30.29578229
134RPS6KB10.29299288
135FGFR30.29255825
136PRKDC0.28123584
137MAP2K60.26709240
138GSK3B0.25720645
139MAPK140.25671266
140BMX0.25301034
141RPS6KA20.25022429
142TAOK10.23892625
143GRK60.23827786
144LRRK20.23769218
145ERN10.23264551
146DAPK10.22279497
147PRPF4B0.19964996
148FGFR10.19938777
149INSRR0.19575802
150PDPK10.18543646
151PTK60.17842482
152EGFR0.17816813
153CDK90.17258732
154CSNK1A10.16087233
155CDK190.14409383
156MAPK10.13206903
157MAPK110.12472321
158MAPKAPK20.12077969

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.90377562
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51120050
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.47008105
4DNA replication_Homo sapiens_hsa030303.43151777
5One carbon pool by folate_Homo sapiens_hsa006703.00298274
6RNA transport_Homo sapiens_hsa030132.83404739
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68863677
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59652244
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.52733888
10RNA polymerase_Homo sapiens_hsa030202.39258411
11Homologous recombination_Homo sapiens_hsa034402.30021696
12Proteasome_Homo sapiens_hsa030502.25667330
13Spliceosome_Homo sapiens_hsa030402.21220186
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.18106968
15Nucleotide excision repair_Homo sapiens_hsa034202.12077375
16Base excision repair_Homo sapiens_hsa034102.11147136
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.01002131
18Fanconi anemia pathway_Homo sapiens_hsa034602.00703977
19Cell cycle_Homo sapiens_hsa041101.89258656
20Circadian rhythm_Homo sapiens_hsa047101.82188533
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.81884456
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.79060042
23Biosynthesis of amino acids_Homo sapiens_hsa012301.76305591
24Ribosome_Homo sapiens_hsa030101.73240325
25Fructose and mannose metabolism_Homo sapiens_hsa000511.72191093
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68030584
27Folate biosynthesis_Homo sapiens_hsa007901.64140082
28Pyrimidine metabolism_Homo sapiens_hsa002401.63606829
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62402016
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.57949735
31Vibrio cholerae infection_Homo sapiens_hsa051101.57387264
32Selenocompound metabolism_Homo sapiens_hsa004501.54153311
33Sphingolipid metabolism_Homo sapiens_hsa006001.53770066
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.44919422
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43298387
36Glutathione metabolism_Homo sapiens_hsa004801.38547046
37Carbon metabolism_Homo sapiens_hsa012001.37982930
38Dorso-ventral axis formation_Homo sapiens_hsa043201.36474256
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32553004
40Pentose phosphate pathway_Homo sapiens_hsa000301.30342421
41ECM-receptor interaction_Homo sapiens_hsa045121.28602831
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.27650552
43p53 signaling pathway_Homo sapiens_hsa041151.25321091
44mRNA surveillance pathway_Homo sapiens_hsa030151.24501411
45Non-homologous end-joining_Homo sapiens_hsa034501.22867698
46Basal transcription factors_Homo sapiens_hsa030221.19887211
47Retinol metabolism_Homo sapiens_hsa008301.18815370
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18268342
49Mineral absorption_Homo sapiens_hsa049781.13025275
50Pancreatic secretion_Homo sapiens_hsa049721.12529914
51Vitamin B6 metabolism_Homo sapiens_hsa007501.12310110
52Starch and sucrose metabolism_Homo sapiens_hsa005001.10042723
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08316189
54RNA degradation_Homo sapiens_hsa030181.07625232
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07191381
56Hepatitis C_Homo sapiens_hsa051601.05019076
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03736618
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02065234
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01198338
60Arginine and proline metabolism_Homo sapiens_hsa003301.00305324
61Hippo signaling pathway_Homo sapiens_hsa043900.99506091
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.99172054
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97252715
64Vitamin digestion and absorption_Homo sapiens_hsa049770.96526690
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95607299
66Fatty acid biosynthesis_Homo sapiens_hsa000610.93097875
67Choline metabolism in cancer_Homo sapiens_hsa052310.88872952
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.88675848
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88174579
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88005360
71Tight junction_Homo sapiens_hsa045300.87644034
72Amoebiasis_Homo sapiens_hsa051460.87604757
73Systemic lupus erythematosus_Homo sapiens_hsa053220.86165977
74Protein digestion and absorption_Homo sapiens_hsa049740.84805683
75Focal adhesion_Homo sapiens_hsa045100.83015622
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82216313
77Insulin resistance_Homo sapiens_hsa049310.82132085
78Regulation of autophagy_Homo sapiens_hsa041400.80931376
79Renin-angiotensin system_Homo sapiens_hsa046140.80197136
80Insulin signaling pathway_Homo sapiens_hsa049100.79882384
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77253981
82Purine metabolism_Homo sapiens_hsa002300.77188915
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76758494
84Galactose metabolism_Homo sapiens_hsa000520.74964388
85PPAR signaling pathway_Homo sapiens_hsa033200.73682710
86Basal cell carcinoma_Homo sapiens_hsa052170.73220941
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72698355
88AMPK signaling pathway_Homo sapiens_hsa041520.71615170
89Lysosome_Homo sapiens_hsa041420.70944963
90Tyrosine metabolism_Homo sapiens_hsa003500.70622881
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67586361
92Proteoglycans in cancer_Homo sapiens_hsa052050.66905662
93ErbB signaling pathway_Homo sapiens_hsa040120.66727547
94Arginine biosynthesis_Homo sapiens_hsa002200.66574287
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66406407
96Endocytosis_Homo sapiens_hsa041440.65257514
97Nitrogen metabolism_Homo sapiens_hsa009100.64326582
98Endometrial cancer_Homo sapiens_hsa052130.62559162
99Fatty acid elongation_Homo sapiens_hsa000620.62160714
100Chronic myeloid leukemia_Homo sapiens_hsa052200.61157356
101Prostate cancer_Homo sapiens_hsa052150.60778029
102Pyruvate metabolism_Homo sapiens_hsa006200.60759133
103Adherens junction_Homo sapiens_hsa045200.60061799
104Fatty acid metabolism_Homo sapiens_hsa012120.59969353
105Other glycan degradation_Homo sapiens_hsa005110.59646511
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58795350
107Renal cell carcinoma_Homo sapiens_hsa052110.57820407
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57747360
109Propanoate metabolism_Homo sapiens_hsa006400.57496345
110Lysine degradation_Homo sapiens_hsa003100.56690952
111Tryptophan metabolism_Homo sapiens_hsa003800.56042731
112Viral carcinogenesis_Homo sapiens_hsa052030.54334707
113Epstein-Barr virus infection_Homo sapiens_hsa051690.54277005
114Glucagon signaling pathway_Homo sapiens_hsa049220.54073716
115Pancreatic cancer_Homo sapiens_hsa052120.53407432
116ABC transporters_Homo sapiens_hsa020100.53041064
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52648687
118Sulfur metabolism_Homo sapiens_hsa009200.52409569
119Oocyte meiosis_Homo sapiens_hsa041140.52292900
120Arachidonic acid metabolism_Homo sapiens_hsa005900.51962952
121beta-Alanine metabolism_Homo sapiens_hsa004100.50960465
122Metabolic pathways_Homo sapiens_hsa011000.49604640
123Thyroid hormone synthesis_Homo sapiens_hsa049180.48005573
124Hedgehog signaling pathway_Homo sapiens_hsa043400.47540367
125Butanoate metabolism_Homo sapiens_hsa006500.45260086
126Caffeine metabolism_Homo sapiens_hsa002320.44275869
127MicroRNAs in cancer_Homo sapiens_hsa052060.44128356
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43524505
129Thyroid cancer_Homo sapiens_hsa052160.43256180
130Gastric acid secretion_Homo sapiens_hsa049710.41952481
131FoxO signaling pathway_Homo sapiens_hsa040680.39244857
132Pathways in cancer_Homo sapiens_hsa052000.38667153
133Fatty acid degradation_Homo sapiens_hsa000710.37928344
134TGF-beta signaling pathway_Homo sapiens_hsa043500.37350617
135Bladder cancer_Homo sapiens_hsa052190.35705315
136Peroxisome_Homo sapiens_hsa041460.33093175
137Sulfur relay system_Homo sapiens_hsa041220.32985387
138mTOR signaling pathway_Homo sapiens_hsa041500.31549017
139Collecting duct acid secretion_Homo sapiens_hsa049660.28259378
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27938331
141Histidine metabolism_Homo sapiens_hsa003400.27639604
142Antigen processing and presentation_Homo sapiens_hsa046120.27615589
143Chemical carcinogenesis_Homo sapiens_hsa052040.26495387
144Glycerolipid metabolism_Homo sapiens_hsa005610.25511007
145Small cell lung cancer_Homo sapiens_hsa052220.24770574
146Bile secretion_Homo sapiens_hsa049760.24007289
147Notch signaling pathway_Homo sapiens_hsa043300.23400735
148Phenylalanine metabolism_Homo sapiens_hsa003600.22975915
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22755984
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.22293921
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21403793
152Inositol phosphate metabolism_Homo sapiens_hsa005620.17380832

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