TFDP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.00108162
2protein localization to kinetochore (GO:0034501)5.21741602
3DNA strand elongation involved in DNA replication (GO:0006271)5.14017640
4DNA replication initiation (GO:0006270)5.02483184
5DNA strand elongation (GO:0022616)4.88526619
6nuclear pore complex assembly (GO:0051292)4.64362473
7telomere maintenance via semi-conservative replication (GO:0032201)4.61815558
8nuclear pore organization (GO:0006999)4.59608686
9protoporphyrinogen IX metabolic process (GO:0046501)4.57853407
10protein localization to chromosome, centromeric region (GO:0071459)4.38776480
11IMP biosynthetic process (GO:0006188)4.32779650
12mitotic nuclear envelope disassembly (GO:0007077)4.30737279
13mitotic chromosome condensation (GO:0007076)4.22203850
14folic acid-containing compound biosynthetic process (GO:0009396)4.14601774
15telomere maintenance via recombination (GO:0000722)4.13928534
16DNA replication checkpoint (GO:0000076)4.13830695
17DNA replication-dependent nucleosome assembly (GO:0006335)4.13662958
18DNA replication-dependent nucleosome organization (GO:0034723)4.13662958
19mitotic recombination (GO:0006312)4.13223406
20nucleobase biosynthetic process (GO:0046112)4.04806463
21nuclear envelope disassembly (GO:0051081)4.00936457
22membrane disassembly (GO:0030397)4.00936457
23sister chromatid segregation (GO:0000819)3.92894073
24mitotic sister chromatid segregation (GO:0000070)3.91718425
25IMP metabolic process (GO:0046040)3.91002171
26mitotic metaphase plate congression (GO:0007080)3.86358034
27formation of translation preinitiation complex (GO:0001731)3.85406524
28DNA duplex unwinding (GO:0032508)3.83188310
29mitotic sister chromatid cohesion (GO:0007064)3.81893764
30DNA geometric change (GO:0032392)3.81152540
31protoporphyrinogen IX biosynthetic process (GO:0006782)3.77625052
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75722106
33telomere maintenance via telomere lengthening (GO:0010833)3.69963505
34chromatin remodeling at centromere (GO:0031055)3.69528256
35ribosomal small subunit assembly (GO:0000028)3.68737314
36CENP-A containing nucleosome assembly (GO:0034080)3.66891738
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.65379092
38kinetochore organization (GO:0051383)3.64941495
39regulation of translational termination (GO:0006449)3.63345761
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61793320
41ribosomal small subunit biogenesis (GO:0042274)3.61469606
42purine nucleobase biosynthetic process (GO:0009113)3.60546261
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60380902
44DNA replication-independent nucleosome organization (GO:0034724)3.59663751
45DNA replication-independent nucleosome assembly (GO:0006336)3.59663751
46regulation of RNA export from nucleus (GO:0046831)3.55407856
47translesion synthesis (GO:0019985)3.50688888
48pore complex assembly (GO:0046931)3.50617051
49cellular protein complex localization (GO:0034629)3.48069851
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47035091
51attachment of spindle microtubules to kinetochore (GO:0008608)3.46111569
52metaphase plate congression (GO:0051310)3.45620412
53nucleobase-containing small molecule interconversion (GO:0015949)3.44226429
54negative regulation of RNA splicing (GO:0033119)3.42869228
55regulation of spindle organization (GO:0090224)3.41460894
56positive regulation of chromosome segregation (GO:0051984)3.38024515
57protein complex localization (GO:0031503)3.33730935
58DNA packaging (GO:0006323)3.32830003
59chromatin assembly or disassembly (GO:0006333)3.32306917
60COPI coating of Golgi vesicle (GO:0048205)3.31837633
61Golgi transport vesicle coating (GO:0048200)3.31837633
62spliceosomal tri-snRNP complex assembly (GO:0000244)3.31197121
63heterochromatin organization (GO:0070828)3.30596683
64maturation of SSU-rRNA (GO:0030490)3.30008201
65establishment of chromosome localization (GO:0051303)3.27014439
66mRNA stabilization (GO:0048255)3.25239008
67RNA stabilization (GO:0043489)3.25239008
68DNA synthesis involved in DNA repair (GO:0000731)3.24407609
69protein localization to chromosome (GO:0034502)3.22843872
70DNA conformation change (GO:0071103)3.22544905
71dosage compensation (GO:0007549)3.21897491
72regulation of histone H3-K9 methylation (GO:0051570)3.21152499
73DNA topological change (GO:0006265)3.20542646
74nuclear envelope organization (GO:0006998)3.18411970
75ribosome assembly (GO:0042255)3.17374036
76negative regulation of mRNA processing (GO:0050686)3.15204573
77proline biosynthetic process (GO:0006561)3.14763465
78postreplication repair (GO:0006301)3.13345895
79histone exchange (GO:0043486)3.11466306
80regulation of centrosome cycle (GO:0046605)3.10012941
813-UTR-mediated mRNA stabilization (GO:0070935)3.08639767
82protein export from nucleus (GO:0006611)3.08359332
83regulation of chromosome segregation (GO:0051983)3.08157709
84regulation of translational fidelity (GO:0006450)3.05815470
85deoxyribonucleotide biosynthetic process (GO:0009263)3.04927060
86meiotic chromosome segregation (GO:0045132)3.03831827
87translational termination (GO:0006415)3.02528668
88viral transcription (GO:0019083)3.02027867
89regulation of nucleobase-containing compound transport (GO:0032239)3.01938378
90regulation of sister chromatid cohesion (GO:0007063)3.01924792
91chromatin assembly (GO:0031497)3.01172981
92ATP-dependent chromatin remodeling (GO:0043044)2.99087107
93positive regulation of DNA-dependent DNA replication (GO:2000105)2.98489010
94regulation of mammary gland epithelial cell proliferation (GO:0033599)2.97649917
95telomere maintenance (GO:0000723)2.96621877
96somatic hypermutation of immunoglobulin genes (GO:0016446)2.95991102
97somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95991102
98telomere organization (GO:0032200)2.95293377
99ribosome biogenesis (GO:0042254)2.95270733
100mRNA splicing, via spliceosome (GO:0000398)2.94884975
101RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94884975
102spindle checkpoint (GO:0031577)2.94194258
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94044359
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94044359
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.94044359
106RNA splicing, via transesterification reactions (GO:0000375)2.93972197
107chromosome condensation (GO:0030261)2.93391942
108kinetochore assembly (GO:0051382)2.93316234
109establishment of integrated proviral latency (GO:0075713)2.93007435
110translational initiation (GO:0006413)2.92378531
111chromosome segregation (GO:0007059)2.90427131
112negative regulation of mRNA metabolic process (GO:1903312)2.90330862
113negative regulation of chromosome segregation (GO:0051985)2.89076985
114folic acid metabolic process (GO:0046655)2.87240571
115spindle assembly checkpoint (GO:0071173)2.86813365
116regulation of mitotic spindle organization (GO:0060236)2.86634887
117translational elongation (GO:0006414)2.85568449
118base-excision repair (GO:0006284)2.85065751
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.84882831
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84882831
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84882831
122negative regulation of sister chromatid segregation (GO:0033046)2.84882831
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84019285
124ribonucleoprotein complex biogenesis (GO:0022613)2.82637637
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82181373
126mitotic spindle assembly checkpoint (GO:0007094)2.81154657
127regulation of DNA endoreduplication (GO:0032875)2.80706489
128deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70839452
129porphyrin-containing compound biosynthetic process (GO:0006779)2.67431274
130pentose-phosphate shunt (GO:0006098)2.64766087
131establishment of viral latency (GO:0019043)2.62477488
132non-recombinational repair (GO:0000726)2.60779960
133double-strand break repair via nonhomologous end joining (GO:0006303)2.60779960
134glucocorticoid receptor signaling pathway (GO:0042921)2.55738333
135mitotic G1 DNA damage checkpoint (GO:0031571)2.55155043
136nuclear envelope reassembly (GO:0031468)2.55146190
137mitotic nuclear envelope reassembly (GO:0007084)2.55146190
138negative regulation of erythrocyte differentiation (GO:0045647)2.53916502
139cellular hyperosmotic response (GO:0071474)2.52532968
140DNA ligation (GO:0006266)2.51077276
141mRNA transport (GO:0051028)2.50416298
142viral mRNA export from host cell nucleus (GO:0046784)2.48933656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.99034646
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.18960536
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02085467
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68519586
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.41980120
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.98601791
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81670703
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62926050
9AR_21909140_ChIP-Seq_LNCAP_Human2.48744751
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43780137
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.38778656
12MYC_22102868_ChIP-Seq_BL_Human2.33099420
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.32224284
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26852104
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26654533
16XRN2_22483619_ChIP-Seq_HELA_Human2.18887395
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.10112645
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09747729
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09198882
20E2F7_22180533_ChIP-Seq_HELA_Human10.8096301
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.98469232
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97680458
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94512217
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.91747938
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86001186
26* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85043150
27VDR_23849224_ChIP-Seq_CD4+_Human1.84523730
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83452731
29ZNF263_19887448_ChIP-Seq_K562_Human1.83046645
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81038436
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75791096
32CIITA_25753668_ChIP-Seq_RAJI_Human1.73695196
33FOXP3_21729870_ChIP-Seq_TREG_Human1.72876305
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72269102
35DCP1A_22483619_ChIP-Seq_HELA_Human1.68056534
36TTF2_22483619_ChIP-Seq_HELA_Human1.66442070
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64369893
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62323933
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61981239
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61793477
41* GABP_19822575_ChIP-Seq_HepG2_Human1.59534182
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55667367
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51225828
44ELK1_19687146_ChIP-ChIP_HELA_Human1.51091159
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48815846
46KDM5A_27292631_Chip-Seq_BREAST_Human1.48227722
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46133170
48VDR_21846776_ChIP-Seq_THP-1_Human1.45399173
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41260928
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.40903887
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38850366
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38297293
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33892035
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33552355
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33487838
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33463291
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32283035
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.32213835
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31848190
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31509272
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28867247
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27768396
63* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26982752
64* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24491441
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24268411
66GATA1_22025678_ChIP-Seq_K562_Human1.24101450
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23928618
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21781532
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21055914
70CLOCK_20551151_ChIP-Seq_293T_Human1.20294892
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16912920
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15477377
73TFEB_21752829_ChIP-Seq_HELA_Human1.14735623
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14587143
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13715015
76RACK7_27058665_Chip-Seq_MCF-7_Human1.13658570
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12937041
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08916403
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08025793
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07787074
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06473779
82ATF3_27146783_Chip-Seq_COLON_Human1.05164760
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04556399
84* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03220554
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.01719759
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01564752
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00267017
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99690231
89NCOR1_26117541_ChIP-Seq_K562_Human0.99603814
90LXR_22292898_ChIP-Seq_THP-1_Human0.99437593
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99311867
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99044283
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99002633
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98908387
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97259997
96* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96953496
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96820093
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96209679
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95658392
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95047334
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93264766
102MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93261504
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93170524
104SPI1_23547873_ChIP-Seq_NB4_Human0.92864822
105* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91822613
106KDM2B_26808549_Chip-Seq_DND41_Human0.90649356
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90268918
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89767457
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88649937
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86907496
111CHD1_26751641_Chip-Seq_LNCaP_Human0.85963775
112UTX_26944678_Chip-Seq_JUKART_Human0.85724362
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85233295
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82342460
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81883139
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.81854711
117MYC_18940864_ChIP-ChIP_HL60_Human0.81765943
118MYB_26560356_Chip-Seq_TH2_Human0.79791254
119MYB_26560356_Chip-Seq_TH1_Human0.78278882
120MAF_26560356_Chip-Seq_TH1_Human0.78217291
121* TCF7_22412390_ChIP-Seq_EML_Mouse0.75624334
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75618346
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75028685
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.73767957
125* SRF_21415370_ChIP-Seq_HL-1_Mouse0.73429428
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.73422457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.65549717
2MP0010094_abnormal_chromosome_stability4.53963955
3MP0003111_abnormal_nucleus_morphology4.18395481
4MP0008057_abnormal_DNA_replication4.00348281
5MP0004957_abnormal_blastocyst_morpholog3.99670499
6MP0003077_abnormal_cell_cycle3.71566961
7MP0010352_gastrointestinal_tract_polyps2.97511148
8MP0002396_abnormal_hematopoietic_system2.87095095
9MP0008007_abnormal_cellular_replicative2.71667221
10MP0008058_abnormal_DNA_repair2.63511020
11MP0003123_paternal_imprinting2.58008547
12MP0003656_abnormal_erythrocyte_physiolo2.44866943
13MP0001730_embryonic_growth_arrest2.43030178
14MP0008932_abnormal_embryonic_tissue2.36440980
15MP0000350_abnormal_cell_proliferation2.32826187
16MP0010307_abnormal_tumor_latency2.22768794
17MP0004185_abnormal_adipocyte_glucose2.13826781
18MP0004808_abnormal_hematopoietic_stem2.00005352
19MP0008438_abnormal_cutaneous_collagen1.95594942
20MP0005451_abnormal_body_composition1.90278201
21MP0006054_spinal_hemorrhage1.80065398
22MP0005076_abnormal_cell_differentiation1.79438125
23* MP0001697_abnormal_embryo_size1.77823884
24MP0000490_abnormal_crypts_of1.77383085
25* MP0001672_abnormal_embryogenesis/_devel1.77263429
26* MP0005380_embryogenesis_phenotype1.77263429
27MP0004197_abnormal_fetal_growth/weight/1.72420768
28MP0008877_abnormal_DNA_methylation1.72297517
29* MP0003984_embryonic_growth_retardation1.66470503
30MP0003705_abnormal_hypodermis_morpholog1.65446882
31MP0003121_genomic_imprinting1.65371853
32MP0005501_abnormal_skin_physiology1.65286925
33* MP0002080_prenatal_lethality1.63286058
34* MP0002088_abnormal_embryonic_growth/wei1.62498185
35MP0002085_abnormal_embryonic_tissue1.60311244
36MP0002084_abnormal_developmental_patter1.58561210
37MP0005623_abnormal_meninges_morphology1.53302650
38* MP0002086_abnormal_extraembryonic_tissu1.51594798
39MP0002009_preneoplasia1.50543126
40MP0003567_abnormal_fetal_cardiomyocyte1.50126542
41MP0002796_impaired_skin_barrier1.48263005
42MP0002060_abnormal_skin_morphology1.46323885
43MP0000537_abnormal_urethra_morphology1.46047432
44MP0002019_abnormal_tumor_incidence1.43872450
45MP0000313_abnormal_cell_death1.41177102
46MP0003786_premature_aging1.38016670
47MP0005397_hematopoietic_system_phenotyp1.37138007
48MP0001545_abnormal_hematopoietic_system1.37138007
49MP0003453_abnormal_keratinocyte_physiol1.34267345
50MP0004147_increased_porphyrin_level1.32065396
51MP0000703_abnormal_thymus_morphology1.27633299
52MP0009278_abnormal_bone_marrow1.26159441
53MP0002877_abnormal_melanocyte_morpholog1.21646536
54MP0003763_abnormal_thymus_physiology1.16830348
55MP0002398_abnormal_bone_marrow1.16071049
56MP0010030_abnormal_orbit_morphology1.15642960
57MP0009333_abnormal_splenocyte_physiolog1.13683291
58MP0009053_abnormal_anal_canal1.13389254
59MP0003566_abnormal_cell_adhesion1.11108607
60MP0003890_abnormal_embryonic-extraembry1.06673681
61MP0001293_anophthalmia1.05548931
62MP0009697_abnormal_copulation1.02894964
63MP0002722_abnormal_immune_system1.02546322
64MP0001915_intracranial_hemorrhage1.01507703
65MP0005257_abnormal_intraocular_pressure1.01471478
66MP0009672_abnormal_birth_weight1.00906460
67MP0005023_abnormal_wound_healing1.00763057
68MP0008260_abnormal_autophagy0.99680021
69MP0001216_abnormal_epidermal_layer0.98838643
70MP0001661_extended_life_span0.97741914
71MP0003091_abnormal_cell_migration0.95866178
72MP0001348_abnormal_lacrimal_gland0.95420822
73MP0000858_altered_metastatic_potential0.93530116
74MP0000689_abnormal_spleen_morphology0.91980504
75MP0001849_ear_inflammation0.91724949
76MP0009931_abnormal_skin_appearance0.91459363
77MP0003941_abnormal_skin_development0.90475931
78MP0002210_abnormal_sex_determination0.89793395
79MP0009703_decreased_birth_body0.88956306
80MP0000733_abnormal_muscle_development0.88229514
81MP0000003_abnormal_adipose_tissue0.85977788
82MP0005384_cellular_phenotype0.84304208
83MP0001346_abnormal_lacrimal_gland0.84275449
84MP0000428_abnormal_craniofacial_morphol0.83765328
85MP0002429_abnormal_blood_cell0.83589564
86MP0001145_abnormal_male_reproductive0.83262285
87MP0005621_abnormal_cell_physiology0.82932971
88MP0003119_abnormal_digestive_system0.82816153
89MP0002111_abnormal_tail_morphology0.82673268
90MP0004264_abnormal_extraembryonic_tissu0.82069397
91MP0005666_abnormal_adipose_tissue0.81753837
92MP0000678_abnormal_parathyroid_gland0.80850506
93MP0004272_abnormal_basement_membrane0.78414632
94MP0003937_abnormal_limbs/digits/tail_de0.77408992
95MP0000762_abnormal_tongue_morphology0.76137912
96MP0003221_abnormal_cardiomyocyte_apopto0.75302609
97MP0003115_abnormal_respiratory_system0.74888921
98MP0000477_abnormal_intestine_morphology0.74028314
99MP0000358_abnormal_cell_content/0.73266205
100MP0002925_abnormal_cardiovascular_devel0.73009589
101MP0001853_heart_inflammation0.72786600
102MP0001881_abnormal_mammary_gland0.72712044
103MP0000759_abnormal_skeletal_muscle0.72564219
104MP0005083_abnormal_biliary_tract0.71775128
105MP0002092_abnormal_eye_morphology0.71750222
106MP0003303_peritoneal_inflammation0.70267163
107MP0003315_abnormal_perineum_morphology0.70169484
108MP0000627_abnormal_mammary_gland0.69984905
109MP0005275_abnormal_skin_tensile0.69513016
110MP0000716_abnormal_immune_system0.69166380
111MP0000653_abnormal_sex_gland0.68520478
112MP0000747_muscle_weakness0.68203340
113MP0009379_abnormal_foot_pigmentation0.67979388
114MP0010771_integument_phenotype0.66596057
115MP0005409_darkened_coat_color0.66388949
116MP0001929_abnormal_gametogenesis0.65775657
117MP0008770_decreased_survivor_rate0.65300431
118MP0005375_adipose_tissue_phenotype0.65141846
119MP0002970_abnormal_white_adipose0.64115706
120MP0003943_abnormal_hepatobiliary_system0.64105928
121MP0010630_abnormal_cardiac_muscle0.62914362
122MP0000465_gastrointestinal_hemorrhage0.62587788
123MP0002166_altered_tumor_susceptibility0.61196178
124MP0002095_abnormal_skin_pigmentation0.60202129
125MP0004233_abnormal_muscle_weight0.57963639
126MP0001119_abnormal_female_reproductive0.57205932
127MP0002006_tumorigenesis0.56984319
128MP0000266_abnormal_heart_morphology0.56856502
129MP0003935_abnormal_craniofacial_develop0.56686900
130MP0002697_abnormal_eye_size0.56489189
131MP0002160_abnormal_reproductive_system0.56235730
132MP0001286_abnormal_eye_development0.55994913
133MP0010234_abnormal_vibrissa_follicle0.55869765
134MP0000432_abnormal_head_morphology0.55828756
135MP0002075_abnormal_coat/hair_pigmentati0.54218564
136MP0002405_respiratory_system_inflammati0.54083218
137MP0003448_altered_tumor_morphology0.53744533
138MP0000685_abnormal_immune_system0.53055047
139MP0003300_gastrointestinal_ulcer0.52575697
140MP0001243_abnormal_dermal_layer0.52252918

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.95165581
2Selective tooth agenesis (HP:0001592)3.49199731
3Reticulocytopenia (HP:0001896)3.40279843
4Chromsome breakage (HP:0040012)3.39669170
5Insomnia (HP:0100785)3.17650929
6Colon cancer (HP:0003003)3.14168824
7Ependymoma (HP:0002888)3.11942539
8Medulloblastoma (HP:0002885)3.02499024
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00472139
10Premature rupture of membranes (HP:0001788)2.93005602
11Abnormality of chromosome stability (HP:0003220)2.89784672
12Abnormality of cells of the erythroid lineage (HP:0012130)2.87016334
13Progressive muscle weakness (HP:0003323)2.86562808
14Deviation of the thumb (HP:0009603)2.83997145
15Short 4th metacarpal (HP:0010044)2.80024413
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.80024413
17Increased nuchal translucency (HP:0010880)2.78807867
18Proximal placement of thumb (HP:0009623)2.78387100
19Reticulocytosis (HP:0001923)2.74208549
20Thrombocytosis (HP:0001894)2.72949267
21Volvulus (HP:0002580)2.72507006
22Abnormality of the heme biosynthetic pathway (HP:0010472)2.72463535
23Myelodysplasia (HP:0002863)2.72134543
24Abnormal number of erythroid precursors (HP:0012131)2.71485046
25Patellar aplasia (HP:0006443)2.64219694
26Basal cell carcinoma (HP:0002671)2.61579474
27Meckel diverticulum (HP:0002245)2.58253593
28Oral leukoplakia (HP:0002745)2.58020151
29Degeneration of anterior horn cells (HP:0002398)2.55738654
30Abnormality of the anterior horn cell (HP:0006802)2.55738654
31Breast hypoplasia (HP:0003187)2.52987838
32Agnosia (HP:0010524)2.50530629
33Aplastic anemia (HP:0001915)2.50186217
34Abnormality of the preputium (HP:0100587)2.49571368
3511 pairs of ribs (HP:0000878)2.48437938
36Protrusio acetabuli (HP:0003179)2.48423623
37Microvesicular hepatic steatosis (HP:0001414)2.47020809
38Ankyloglossia (HP:0010296)2.46507834
39Aplasia/Hypoplasia of the patella (HP:0006498)2.45933977
40Abnormality of the ileum (HP:0001549)2.45376728
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.44760355
42Abnormality of reticulocytes (HP:0004312)2.44424254
43Ectopic kidney (HP:0000086)2.44158232
44Abnormality of the calcaneus (HP:0008364)2.42825376
45High pitched voice (HP:0001620)2.38399044
46Rhabdomyosarcoma (HP:0002859)2.36665266
47Atresia of the external auditory canal (HP:0000413)2.35398803
48Ulnar bowing (HP:0003031)2.33966602
49Cutaneous melanoma (HP:0012056)2.33120430
50Orthostatic hypotension (HP:0001278)2.33063191
51Squamous cell carcinoma (HP:0002860)2.32302787
52Osteolytic defects of the hand bones (HP:0009699)2.32299630
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.32299630
54Neoplasm of the pancreas (HP:0002894)2.31206135
55Achilles tendon contracture (HP:0001771)2.29565109
56Small intestinal stenosis (HP:0012848)2.28025177
57Duodenal stenosis (HP:0100867)2.28025177
58Abnormal number of incisors (HP:0011064)2.27829573
59Prominent nose (HP:0000448)2.24344365
60Abnormality of the astrocytes (HP:0100707)2.23240354
61Astrocytoma (HP:0009592)2.23240354
62Missing ribs (HP:0000921)2.22848481
63Cholelithiasis (HP:0001081)2.21028232
64Absent thumb (HP:0009777)2.20181269
65Increased connective tissue (HP:0009025)2.15038136
66Progressive external ophthalmoplegia (HP:0000590)2.13645943
67Increased density of long bones (HP:0006392)2.12944774
68Fragile skin (HP:0001030)2.12481840
69Abnormality of oral frenula (HP:0000190)2.11879710
70Cholecystitis (HP:0001082)2.11099841
71Abnormal gallbladder physiology (HP:0012438)2.11099841
72Abnormal lung lobation (HP:0002101)2.10384949
73Cafe-au-lait spot (HP:0000957)2.09505083
74Multiple enchondromatosis (HP:0005701)2.05757854
75Slender long bone (HP:0003100)2.04342147
76Amaurosis fugax (HP:0100576)2.03236921
77Long palpebral fissure (HP:0000637)2.03129617
78Abnormality of the umbilical cord (HP:0010881)2.01900116
79Vertebral compression fractures (HP:0002953)2.01085333
80Bone marrow hypocellularity (HP:0005528)2.00461275
81Overlapping toe (HP:0001845)2.00159221
82Termporal pattern (HP:0011008)1.99538491
83Insidious onset (HP:0003587)1.99538491
84Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99073755
85Distal lower limb amyotrophy (HP:0008944)1.99047365
86Asymmetry of the thorax (HP:0001555)1.98167689
87Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97919987
88Sloping forehead (HP:0000340)1.97366614
89Abnormality of the carotid arteries (HP:0005344)1.95932334
90Poikilocytosis (HP:0004447)1.94795171
91Glioma (HP:0009733)1.94668389
92Nonimmune hydrops fetalis (HP:0001790)1.93806217
93Spinal cord lesions (HP:0100561)1.92087964
94Syringomyelia (HP:0003396)1.92087964
95Tracheoesophageal fistula (HP:0002575)1.91714756
96Abnormal umbilical cord blood vessels (HP:0011403)1.91655622
97Single umbilical artery (HP:0001195)1.91655622
98Abnormality of the fetal cardiovascular system (HP:0010948)1.91655622
99Acute myeloid leukemia (HP:0004808)1.91654890
100Abnormality of the Achilles tendon (HP:0005109)1.91470357
101Polycythemia (HP:0001901)1.91437187
102Abnormality of the 4th metacarpal (HP:0010012)1.91302233
103Long eyelashes (HP:0000527)1.91261237
104Facial hemangioma (HP:0000329)1.91068209
105Impulsivity (HP:0100710)1.90977778
106Absent radius (HP:0003974)1.90760273
107Microretrognathia (HP:0000308)1.89452926
108Abnormality of the labia minora (HP:0012880)1.89379717
109Trismus (HP:0000211)1.89181920
110Abnormality of the duodenum (HP:0002246)1.89062871
111Ragged-red muscle fibers (HP:0003200)1.88895923
112Rough bone trabeculation (HP:0100670)1.87656337
113Premature graying of hair (HP:0002216)1.86841650
114Abnormality of the phalanges of the hallux (HP:0010057)1.86422118
115Sparse lateral eyebrow (HP:0005338)1.86213568
116Deep philtrum (HP:0002002)1.85801171
117Pallor (HP:0000980)1.85669463
118Carpal bone hypoplasia (HP:0001498)1.85618565
119Short nail (HP:0001799)1.85587329
120Abnormality of chromosome segregation (HP:0002916)1.84181600
121Abnormality of the fingertips (HP:0001211)1.82779882
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.82604902
123Broad distal phalanx of finger (HP:0009836)1.81954543
124Neoplasm of striated muscle (HP:0009728)1.81128810
125Pseudobulbar signs (HP:0002200)1.80943697
126Elbow flexion contracture (HP:0002987)1.80434060
127Hyperacusis (HP:0010780)1.79557836
128Flared metaphyses (HP:0003015)1.79324538
129Abnormal gallbladder morphology (HP:0012437)1.79254307
130Ovarian neoplasm (HP:0100615)1.78722786
131Renal duplication (HP:0000075)1.78436987
132Abnormality of the distal phalanges of the toes (HP:0010182)1.78364118
133Neoplasm of the oral cavity (HP:0100649)1.77001094
134Biliary tract neoplasm (HP:0100574)1.76799102
135Glossoptosis (HP:0000162)1.76431575
136Lymphoma (HP:0002665)1.75987243
137Short middle phalanx of the 5th finger (HP:0004220)1.75708661
138Deep palmar crease (HP:0006191)1.75250012
139Ankle contracture (HP:0006466)1.75079068
140Neoplasm of the colon (HP:0100273)1.74684953
141Dysmetric saccades (HP:0000641)1.74177910
142Absent forearm bone (HP:0003953)1.74007181
143Aplasia involving forearm bones (HP:0009822)1.74007181
144Preauricular skin tag (HP:0000384)1.73992963
145Broad palm (HP:0001169)1.73910642
146Skin tags (HP:0010609)1.73805907
147Abnormality of the gallbladder (HP:0005264)1.73078730
148Septate vagina (HP:0001153)1.73034933
149Onycholysis (HP:0001806)1.72692413
150Centrally nucleated skeletal muscle fibers (HP:0003687)1.71924655
151Cellular immunodeficiency (HP:0005374)1.71697035
152Fatigue (HP:0012378)1.71275739
153Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.70285198
154Freckling (HP:0001480)1.70019305
155Macrocytic anemia (HP:0001972)1.69897802
156Asplenia (HP:0001746)1.69343348
157Poikiloderma (HP:0001029)1.69003004
158Ridged nail (HP:0001807)1.68754114
159IgM deficiency (HP:0002850)1.68753096
160Pelvic girdle muscle weakness (HP:0003749)1.68306885
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.67968687
162Disproportionate tall stature (HP:0001519)1.67787416
163Relative macrocephaly (HP:0004482)1.65407124
164Broad face (HP:0000283)1.62889265
165Abnormality of skeletal muscle fiber size (HP:0012084)1.61920795
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.61385414
167Paralysis (HP:0003470)1.59138549
168Wormian bones (HP:0002645)1.58098779
169Overriding aorta (HP:0002623)1.57626875
170Natal tooth (HP:0000695)1.56957374
171Patellar dislocation (HP:0002999)1.56818541
172Abnormality of nail color (HP:0100643)1.56620816
173Spinal rigidity (HP:0003306)1.55955951
174Abnormal foot bone ossification (HP:0010675)1.55325214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.18322195
2WEE13.75696680
3SMG13.71125540
4NEK23.02078802
5BUB12.96517397
6EEF2K2.94898309
7PRPF4B2.88013118
8IRAK32.54308342
9PASK2.41461347
10CDK122.24499723
11TTK2.22167489
12PKN22.20909947
13NEK12.17628873
14EIF2AK12.06508473
15ICK2.05802423
16TSSK62.01407487
17MAP3K102.01005839
18SRPK12.00571283
19BRSK22.00030820
20MKNK11.96924337
21SCYL21.88883482
22RPS6KB21.86924035
23STK101.83206033
24ATR1.82870786
25PLK11.75097380
26CDK71.71930600
27ACVR1B1.67882371
28AURKB1.62356553
29MAP3K81.62342343
30PLK41.52755888
31TESK21.50991577
32CDK41.50728831
33VRK21.47716789
34PLK31.47110245
35TGFBR11.46355810
36RPS6KA41.44458976
37CHEK21.41035276
38MST1R1.40814058
39TAF11.39529386
40VRK11.37150987
41EIF2AK31.35859821
42PAK41.34276004
43* CHEK11.29311770
44DYRK31.26779462
45TRIB31.23378798
46BRSK11.23218067
47LRRK21.22710727
48FLT31.19109959
49PBK1.19063466
50MKNK21.16376553
51SIK11.14634435
52NME21.13414861
53MAP3K131.10583172
54STK41.09047486
55BRD41.08656080
56ALK1.08241375
57BRAF1.06343175
58ARAF1.06157029
59KSR21.03405576
60CDK61.03074378
61ERN11.01407100
62AURKA1.00090894
63LATS20.97821674
64ATM0.97408831
65STK30.95715268
66CCNB10.94163049
67MAP4K10.91947687
68CDK20.91663973
69TTN0.89516770
70TESK10.88178433
71TLK10.85708075
72CLK10.85598452
73PIM10.84164868
74MAP3K90.83828142
75MAPK110.82930458
76CDK90.78953437
77CDK80.77895521
78MAP3K140.77613252
79STK240.75564452
80MAP2K30.74938015
81NEK90.70490691
82EPHA20.70099065
83BTK0.68552442
84LATS10.68526764
85MET0.67933111
86CDK10.67757570
87MELK0.66970281
88GRK60.66165004
89PAK20.66003045
90PNCK0.63759820
91ZAK0.63018865
92MTOR0.62347157
93PAK10.61780194
94PTK60.59419834
95CSNK2A20.58957746
96MOS0.58193071
97PTK20.56238188
98IRAK20.53451087
99JAK30.51790880
100TAOK10.51448327
101FGFR10.50685554
102CSNK2A10.47175215
103PIM20.46689329
104AKT20.44986272
105IRAK40.44122910
106PRKDC0.42044711
107STK160.41101415
108ILK0.41058595
109DMPK0.39558372
110CAMK1G0.39072530
111TRPM70.38956332
112CDK11A0.37920590
113ZAP700.36111265
114BMX0.35968338
115MAP3K30.35329244
116CDK150.35128782
117CSNK1E0.34945254
118KSR10.34265109
119CAMK1D0.34027019
120CSF1R0.33903557
121PDGFRA0.33798533
122RPS6KB10.33304515
123MAPK140.32205989
124CSNK1D0.30157727
125RPS6KA50.29556263
126LIMK10.29545586
127RAF10.29100938
128AKT10.28052104
129TAOK20.27538067
130PRKCI0.27531043
131EIF2AK20.26604872
132RPS6KL10.26305544
133RPS6KC10.26305544
134MAPKAPK30.26191066
135ERBB30.26088195
136RPS6KA60.24320332

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.37468921
2Mismatch repair_Homo sapiens_hsa034304.25457266
3Spliceosome_Homo sapiens_hsa030403.16172642
4Base excision repair_Homo sapiens_hsa034103.10817794
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09226319
6* Cell cycle_Homo sapiens_hsa041103.07825824
7RNA transport_Homo sapiens_hsa030133.07543763
8One carbon pool by folate_Homo sapiens_hsa006702.84463976
9Homologous recombination_Homo sapiens_hsa034402.81836099
10Nucleotide excision repair_Homo sapiens_hsa034202.80124069
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52327222
12Ribosome_Homo sapiens_hsa030102.42968322
13Non-homologous end-joining_Homo sapiens_hsa034502.21779716
14Fanconi anemia pathway_Homo sapiens_hsa034602.08003581
15RNA polymerase_Homo sapiens_hsa030202.05771559
16mRNA surveillance pathway_Homo sapiens_hsa030151.99357575
17Proteasome_Homo sapiens_hsa030501.95697395
18Pyrimidine metabolism_Homo sapiens_hsa002401.93264373
19RNA degradation_Homo sapiens_hsa030181.89390517
20p53 signaling pathway_Homo sapiens_hsa041151.68109210
21Basal transcription factors_Homo sapiens_hsa030221.46938636
22Systemic lupus erythematosus_Homo sapiens_hsa053221.36062391
23Viral carcinogenesis_Homo sapiens_hsa052031.32047329
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21512267
25Antigen processing and presentation_Homo sapiens_hsa046121.19243679
26Epstein-Barr virus infection_Homo sapiens_hsa051691.14107965
27MicroRNAs in cancer_Homo sapiens_hsa052061.09782855
28HTLV-I infection_Homo sapiens_hsa051661.08898167
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07203049
30Oocyte meiosis_Homo sapiens_hsa041141.06938235
31Thyroid cancer_Homo sapiens_hsa052161.03549226
32Herpes simplex infection_Homo sapiens_hsa051681.02383504
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01647144
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00956098
35Small cell lung cancer_Homo sapiens_hsa052220.99684701
36Renal cell carcinoma_Homo sapiens_hsa052110.96470965
37Purine metabolism_Homo sapiens_hsa002300.95462687
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94226280
39Chronic myeloid leukemia_Homo sapiens_hsa052200.93622889
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79190556
41Colorectal cancer_Homo sapiens_hsa052100.78722762
42Fructose and mannose metabolism_Homo sapiens_hsa000510.77439198
43Sulfur relay system_Homo sapiens_hsa041220.76029592
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74419985
45Pentose phosphate pathway_Homo sapiens_hsa000300.74328695
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73264252
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.72035069
48Biosynthesis of amino acids_Homo sapiens_hsa012300.71558179
49N-Glycan biosynthesis_Homo sapiens_hsa005100.71337918
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71258965
51Primary immunodeficiency_Homo sapiens_hsa053400.70393368
52Legionellosis_Homo sapiens_hsa051340.70088935
53Hepatitis B_Homo sapiens_hsa051610.68193427
54Bladder cancer_Homo sapiens_hsa052190.67625668
55Shigellosis_Homo sapiens_hsa051310.66615814
56Selenocompound metabolism_Homo sapiens_hsa004500.65489199
57Viral myocarditis_Homo sapiens_hsa054160.64807550
58Non-small cell lung cancer_Homo sapiens_hsa052230.64699149
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64454137
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63772566
61Apoptosis_Homo sapiens_hsa042100.61891000
62Alcoholism_Homo sapiens_hsa050340.60897845
63Galactose metabolism_Homo sapiens_hsa000520.60540735
64Prion diseases_Homo sapiens_hsa050200.59970133
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59267959
66Pancreatic cancer_Homo sapiens_hsa052120.58017001
67Pyruvate metabolism_Homo sapiens_hsa006200.57743025
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.57232124
69Insulin signaling pathway_Homo sapiens_hsa049100.56702592
70Hippo signaling pathway_Homo sapiens_hsa043900.56030272
71Adherens junction_Homo sapiens_hsa045200.54586210
72Vitamin B6 metabolism_Homo sapiens_hsa007500.54469450
73AMPK signaling pathway_Homo sapiens_hsa041520.54405392
74ErbB signaling pathway_Homo sapiens_hsa040120.51965267
75Acute myeloid leukemia_Homo sapiens_hsa052210.51910476
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.49874482
77Measles_Homo sapiens_hsa051620.47946003
78mTOR signaling pathway_Homo sapiens_hsa041500.46984538
79Basal cell carcinoma_Homo sapiens_hsa052170.46633084
80Proteoglycans in cancer_Homo sapiens_hsa052050.46603181
81Prostate cancer_Homo sapiens_hsa052150.46473140
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46233279
83Folate biosynthesis_Homo sapiens_hsa007900.46192404
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45738310
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45134548
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45104520
87Notch signaling pathway_Homo sapiens_hsa043300.44848576
88Hepatitis C_Homo sapiens_hsa051600.44723255
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.44135033
90* TGF-beta signaling pathway_Homo sapiens_hsa043500.43162201
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42833001
92Pathways in cancer_Homo sapiens_hsa052000.42589332
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.39956754
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39387588
95HIF-1 signaling pathway_Homo sapiens_hsa040660.39242366
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38693730
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38194544
98Endometrial cancer_Homo sapiens_hsa052130.37025510
99B cell receptor signaling pathway_Homo sapiens_hsa046620.35793391
100Lysine degradation_Homo sapiens_hsa003100.35755296
101Leishmaniasis_Homo sapiens_hsa051400.34963388
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34527798
103ECM-receptor interaction_Homo sapiens_hsa045120.33939794
104Other glycan degradation_Homo sapiens_hsa005110.32995962
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.32821132
106FoxO signaling pathway_Homo sapiens_hsa040680.31709555
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.30985159
108Protein export_Homo sapiens_hsa030600.29904195
109Carbon metabolism_Homo sapiens_hsa012000.29795953
110Influenza A_Homo sapiens_hsa051640.28916035
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27540636
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27518361
113Hematopoietic cell lineage_Homo sapiens_hsa046400.27217010
114Focal adhesion_Homo sapiens_hsa045100.26624967
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26133383
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25220691
117Melanoma_Homo sapiens_hsa052180.25144331
118Toxoplasmosis_Homo sapiens_hsa051450.24650908
119VEGF signaling pathway_Homo sapiens_hsa043700.24545832
120T cell receptor signaling pathway_Homo sapiens_hsa046600.24065615
121Glioma_Homo sapiens_hsa052140.23460791
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22896153
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22267185
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21930321

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »