TFDP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)9.79925923
2protoporphyrinogen IX metabolic process (GO:0046501)6.68307926
3protoporphyrinogen IX biosynthetic process (GO:0006782)6.05032898
4DNA unwinding involved in DNA replication (GO:0006268)4.92456619
5mitotic chromosome condensation (GO:0007076)4.30872770
6behavioral response to nicotine (GO:0035095)4.28196873
7porphyrin-containing compound biosynthetic process (GO:0006779)4.24483492
8regulation of exit from mitosis (GO:0007096)4.05448738
9erythrocyte maturation (GO:0043249)4.01424929
10kinetochore organization (GO:0051383)3.97987151
11tetrapyrrole biosynthetic process (GO:0033014)3.82425371
12viral transcription (GO:0019083)3.71345548
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.69975758
14translational termination (GO:0006415)3.66526214
15heme biosynthetic process (GO:0006783)3.64316152
16sister chromatid segregation (GO:0000819)3.62929742
17regulation of histone H3-K9 methylation (GO:0051570)3.52482809
18DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.52009845
19pre-miRNA processing (GO:0031054)3.49394412
20response to lead ion (GO:0010288)3.42955915
21ribosomal small subunit assembly (GO:0000028)3.37955725
22negative regulation of fibroblast apoptotic process (GO:2000270)3.37627242
23replication fork processing (GO:0031297)3.36741416
24kinetochore assembly (GO:0051382)3.33650283
25nuclear pore complex assembly (GO:0051292)3.33613226
26regulation of sister chromatid cohesion (GO:0007063)3.32413611
27DNA damage response, signal transduction resulting in transcription (GO:0042772)3.26754941
28neuronal stem cell maintenance (GO:0097150)3.25257600
29mitotic sister chromatid segregation (GO:0000070)3.24745269
30maturation of SSU-rRNA (GO:0030490)3.24064790
31somatic diversification of immune receptors (GO:0002200)3.23853467
32CENP-A containing nucleosome assembly (GO:0034080)3.23233918
33DNA replication initiation (GO:0006270)3.22763688
34resolution of meiotic recombination intermediates (GO:0000712)3.22275969
35monoubiquitinated protein deubiquitination (GO:0035520)3.20902659
36generation of neurons (GO:0048699)3.20331209
37somite development (GO:0061053)3.19442181
38somatic cell DNA recombination (GO:0016444)3.19138360
39somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.19138360
40nuclear pore organization (GO:0006999)3.18274152
41centriole replication (GO:0007099)3.17817737
42DNA replication-dependent nucleosome assembly (GO:0006335)3.16571814
43DNA replication-dependent nucleosome organization (GO:0034723)3.16571814
44chromatin remodeling at centromere (GO:0031055)3.14457665
45mitotic sister chromatid cohesion (GO:0007064)3.13608836
46forebrain neuron differentiation (GO:0021879)3.13364908
47protein localization to chromosome, centromeric region (GO:0071459)3.11722767
48dentate gyrus development (GO:0021542)3.07994332
49DNA topological change (GO:0006265)3.07547689
50protein localization to kinetochore (GO:0034501)3.07451224
51DNA replication-independent nucleosome assembly (GO:0006336)3.04898156
52DNA replication-independent nucleosome organization (GO:0034724)3.04898156
53tongue development (GO:0043586)3.01209406
54hemoglobin metabolic process (GO:0020027)2.98861388
55microtubule depolymerization (GO:0007019)2.95331563
56DNA replication checkpoint (GO:0000076)2.95322697
57translational elongation (GO:0006414)2.95214084
58nucleosome assembly (GO:0006334)2.94942116
59porphyrin-containing compound metabolic process (GO:0006778)2.92617888
60histone exchange (GO:0043486)2.92438068
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91983890
62negative regulation of translation, ncRNA-mediated (GO:0040033)2.89840674
63regulation of translation, ncRNA-mediated (GO:0045974)2.89840674
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.89840674
65recombinational repair (GO:0000725)2.89479603
66definitive hemopoiesis (GO:0060216)2.88999804
67chromatin assembly or disassembly (GO:0006333)2.88566738
68double-strand break repair via homologous recombination (GO:0000724)2.88501797
69nucleosome organization (GO:0034728)2.88469167
70negative regulation of histone methylation (GO:0031061)2.87736518
71negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.86049341
72IMP biosynthetic process (GO:0006188)2.85916268
73chromatin assembly (GO:0031497)2.83720745
74DNA strand elongation involved in DNA replication (GO:0006271)2.83206387
75DNA strand elongation (GO:0022616)2.82696800
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81562011
77regulation of nuclear cell cycle DNA replication (GO:0033262)2.80923823
78mismatch repair (GO:0006298)2.80516415
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80054097
80regulation of spindle organization (GO:0090224)2.78545955
81negative regulation of DNA-dependent DNA replication (GO:2000104)2.78541913
82cellular protein complex disassembly (GO:0043624)2.77344968
83DNA ligation (GO:0006266)2.76177054
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76117191
85V(D)J recombination (GO:0033151)2.75098305
86cotranslational protein targeting to membrane (GO:0006613)2.73953643
87notochord development (GO:0030903)2.73588287
88regulation of posttranscriptional gene silencing (GO:0060147)2.71310325
89regulation of gene silencing by miRNA (GO:0060964)2.71310325
90regulation of gene silencing by RNA (GO:0060966)2.71310325
91positive regulation of granulocyte differentiation (GO:0030854)2.71040753
92DNA duplex unwinding (GO:0032508)2.70731755
93DNA geometric change (GO:0032392)2.69536996
94meiotic chromosome segregation (GO:0045132)2.69267661
95positive regulation by host of viral transcription (GO:0043923)2.67194617
96protein targeting to ER (GO:0045047)2.67175184
97ribosomal small subunit biogenesis (GO:0042274)2.66618152
98mitotic metaphase plate congression (GO:0007080)2.66540171
99protein complex disassembly (GO:0043241)2.65918747
100reciprocal meiotic recombination (GO:0007131)2.64299470
101reciprocal DNA recombination (GO:0035825)2.64299470
102positive regulation of chromosome segregation (GO:0051984)2.63749555
103establishment of mitotic spindle localization (GO:0040001)2.63598267
104somitogenesis (GO:0001756)2.63512335
105ATP-dependent chromatin remodeling (GO:0043044)2.63261814
106protein-DNA complex subunit organization (GO:0071824)2.62060593
107positive regulation of mitotic sister chromatid separation (GO:1901970)2.61666437
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61666437
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61666437
110protein-DNA complex assembly (GO:0065004)2.61618838
111chromosome condensation (GO:0030261)2.61547763
112cell proliferation in forebrain (GO:0021846)2.59480417
113viral life cycle (GO:0019058)2.59244960
114regulation of stem cell maintenance (GO:2000036)2.58799947
115metaphase plate congression (GO:0051310)2.58563741
116telomere maintenance via semi-conservative replication (GO:0032201)2.56940157
117DNA recombination (GO:0006310)2.56179146
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56034200
119negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55544855
120negative regulation of DNA-templated transcription, elongation (GO:0032785)2.55544855
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55302862
122DNA strand renaturation (GO:0000733)2.55125409
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.54074616
124macromolecular complex disassembly (GO:0032984)2.52179068
125negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52130878
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52059837
127mucosal-associated lymphoid tissue development (GO:0048537)2.51704046
128Peyers patch development (GO:0048541)2.51704046
129positive regulation of histone H3-K4 methylation (GO:0051571)2.50608557
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50407484
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.50407484
132IMP metabolic process (GO:0046040)2.50093370
133mitotic recombination (GO:0006312)2.49876390
134translesion synthesis (GO:0019985)2.49822875
135DNA double-strand break processing (GO:0000729)2.49569142
136regulation of centrosome cycle (GO:0046605)2.49561490
137negative regulation of epidermal cell differentiation (GO:0045605)2.49138191
138otic vesicle formation (GO:0030916)2.48675187
139attachment of spindle microtubules to kinetochore (GO:0008608)2.48572381
140protein localization to chromosome (GO:0034502)2.48041300
141regulation of helicase activity (GO:0051095)2.47695184
142translational initiation (GO:0006413)2.47334913
143protein localization to endoplasmic reticulum (GO:0070972)2.45394208
144kidney morphogenesis (GO:0060993)2.44852340
145centrosome organization (GO:0051297)2.44221480
146regulation of chromosome segregation (GO:0051983)2.43330047
147spliceosomal complex assembly (GO:0000245)2.42932961
148mitotic nuclear envelope disassembly (GO:0007077)2.42834652
149peptidyl-lysine dimethylation (GO:0018027)2.42830145
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.42624119
151epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.41433415
152nuclear-transcribed mRNA catabolic process (GO:0000956)2.41393771
153neural tube formation (GO:0001841)2.40927488
154erythrocyte differentiation (GO:0030218)2.39345483
155regulation of mitotic spindle checkpoint (GO:1903504)2.38511261
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.38511261
157spindle assembly checkpoint (GO:0071173)2.38380703
158erythrocyte development (GO:0048821)2.38301497
159DNA conformation change (GO:0071103)2.38189838
160mesenchyme development (GO:0060485)2.37584258
161regulation of mitotic spindle organization (GO:0060236)2.37126806
162chromosome segregation (GO:0007059)2.36628111
163regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36514899
164regulation of DNA endoreduplication (GO:0032875)2.36302211
165regulation of telomere maintenance (GO:0032204)2.36218333
166telomere maintenance via recombination (GO:0000722)2.35592527
167negative regulation of thymocyte apoptotic process (GO:0070244)2.35134044
168mitotic DNA integrity checkpoint (GO:0044774)2.34576075
169positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.33984034
170positive regulation of cell cycle G2/M phase transition (GO:1902751)2.33984034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.76085070
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.38090521
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.56516414
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31996826
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.89571497
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02909074
7EZH2_22144423_ChIP-Seq_EOC_Human2.98865539
8ZNF274_21170338_ChIP-Seq_K562_Hela2.70677187
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.53483330
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.43493464
11SOX2_18555785_ChIP-Seq_MESCs_Mouse2.41586196
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38313089
13AR_21909140_ChIP-Seq_LNCAP_Human2.37565792
14IGF1R_20145208_ChIP-Seq_DFB_Human2.37285071
15SOX2_16153702_ChIP-ChIP_HESCs_Human2.36644365
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27480465
17FUS_26573619_Chip-Seq_HEK293_Human2.18249820
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17582894
19IRF1_19129219_ChIP-ChIP_H3396_Human2.08006121
20VDR_22108803_ChIP-Seq_LS180_Human2.07477526
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.05441244
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04940871
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.04854067
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.01031025
25E2F7_22180533_ChIP-Seq_HELA_Human10.3454399
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.99996109
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.99042485
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95854742
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.94279595
30MYC_18940864_ChIP-ChIP_HL60_Human1.88483994
31CIITA_25753668_ChIP-Seq_RAJI_Human1.88187778
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84511268
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82756462
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82190504
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79911184
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76400051
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76260375
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71416800
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70848107
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.66798818
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65055488
42SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.63765189
43NANOG_21062744_ChIP-ChIP_HESCs_Human1.63562027
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61870821
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61016622
46XRN2_22483619_ChIP-Seq_HELA_Human1.57486085
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56258225
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54432313
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53518068
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.51894595
51* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49285639
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47122358
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45653061
54KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44708803
55* GATA1_19941826_ChIP-Seq_K562_Human1.43887091
56SCL_19346495_ChIP-Seq_HPC-7_Human1.41906490
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40611281
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.40208313
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39624877
60GATA1_22025678_ChIP-Seq_K562_Human1.39276282
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39181610
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37109296
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35615534
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34990076
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33767192
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.33370646
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31895984
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31895984
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30655759
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.29859341
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28738358
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27054533
73TAF15_26573619_Chip-Seq_HEK293_Human1.26051193
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22473868
75ELK1_19687146_ChIP-ChIP_HELA_Human1.21842768
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21531892
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20775965
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18712787
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17900727
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17148764
81RNF2_27304074_Chip-Seq_NSC_Mouse1.16918442
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16610422
83SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15836012
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14540341
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14084754
86TTF2_22483619_ChIP-Seq_HELA_Human1.13459929
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.10123970
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10045445
89ER_23166858_ChIP-Seq_MCF-7_Human1.09848343
90GBX2_23144817_ChIP-Seq_PC3_Human1.08867344
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08401562
92* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07864875
93* P300_19829295_ChIP-Seq_ESCs_Human1.07677960
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07215825
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04626644
96FOXP3_21729870_ChIP-Seq_TREG_Human1.04485882
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03732704
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03601358
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03563574
100MYC_22102868_ChIP-Seq_BL_Human1.03025611
101VDR_23849224_ChIP-Seq_CD4+_Human1.02718499
102TP53_22573176_ChIP-Seq_HFKS_Human1.02100141
103ZNF263_19887448_ChIP-Seq_K562_Human1.01840120
104AR_21572438_ChIP-Seq_LNCaP_Human1.00461562
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99746594
106GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99571297
107KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99391060
108TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98991768
109* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98590635
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98547435
111KDM5A_27292631_Chip-Seq_BREAST_Human0.98109521
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97465497
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97188243
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96853221
115EWS_26573619_Chip-Seq_HEK293_Human0.96525776
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96116343
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95549473
118NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95352722
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94676007
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93899646
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93603373
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92654136
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92586000
124NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92556708
125STAT3_23295773_ChIP-Seq_U87_Human0.91889808
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.91865746
127CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91124423
128* SRF_21415370_ChIP-Seq_HL-1_Mouse0.89274034
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89075641
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88677678
131SOX9_26525672_Chip-Seq_HEART_Mouse0.88552837
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87826623
133* TCF4_23295773_ChIP-Seq_U87_Human0.87415596
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85293706
135CBP_20019798_ChIP-Seq_JUKART_Human0.85293706
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83345893
137CHD1_26751641_Chip-Seq_LNCaP_Human0.83207344
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.82688936
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82522407
140* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82119308
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81631959
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81631959
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81631959
144GATA1_26923725_Chip-Seq_HPCs_Mouse0.81055069
145OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80234468
146GATA1_19941827_ChIP-Seq_MEL_Mouse0.79424727
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.77672324
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77642546
149CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77496520
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77478959
151NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77127220
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75049667
153WDR5_24793694_ChIP-Seq_LNCAP_Human0.74056683
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73100465
155ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.72654661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.56884482
2MP0004147_increased_porphyrin_level3.82395534
3MP0006292_abnormal_olfactory_placode3.71416917
4MP0003656_abnormal_erythrocyte_physiolo3.37096785
5MP0000566_synostosis3.08881910
6MP0010094_abnormal_chromosome_stability3.03963864
7MP0003111_abnormal_nucleus_morphology2.60992835
8MP0009379_abnormal_foot_pigmentation2.44006803
9MP0003077_abnormal_cell_cycle2.34563517
10MP0008057_abnormal_DNA_replication2.21082243
11MP0010030_abnormal_orbit_morphology2.12882412
12MP0003123_paternal_imprinting2.07775577
13MP0000537_abnormal_urethra_morphology2.04770797
14MP0000631_abnormal_neuroendocrine_gland1.98663017
15MP0004957_abnormal_blastocyst_morpholog1.94176364
16MP0003890_abnormal_embryonic-extraembry1.92869562
17MP0003693_abnormal_embryo_hatching1.85134921
18MP0006072_abnormal_retinal_apoptosis1.83887395
19MP0003315_abnormal_perineum_morphology1.82751658
20MP0002102_abnormal_ear_morphology1.78882528
21MP0001529_abnormal_vocalization1.78082833
22MP0004084_abnormal_cardiac_muscle1.76303107
23MP0000733_abnormal_muscle_development1.74025110
24MP0004215_abnormal_myocardial_fiber1.70101373
25MP0003121_genomic_imprinting1.68568355
26MP0008789_abnormal_olfactory_epithelium1.61289415
27MP0005083_abnormal_biliary_tract1.56721321
28MP0003567_abnormal_fetal_cardiomyocyte1.55738658
29MP0003137_abnormal_impulse_conducting1.52513486
30MP0002638_abnormal_pupillary_reflex1.50562691
31MP0001730_embryonic_growth_arrest1.48816416
32MP0002837_dystrophic_cardiac_calcinosis1.47113732
33MP0000350_abnormal_cell_proliferation1.44452674
34MP0003136_yellow_coat_color1.43921230
35MP0005187_abnormal_penis_morphology1.43758476
36MP0008058_abnormal_DNA_repair1.43368953
37MP0001293_anophthalmia1.42503360
38MP0002085_abnormal_embryonic_tissue1.41913156
39MP0003938_abnormal_ear_development1.41826842
40MP0005646_abnormal_pituitary_gland1.39717809
41MP0001849_ear_inflammation1.38470111
42MP0002160_abnormal_reproductive_system1.38138384
43MP0002084_abnormal_developmental_patter1.37749604
44MP0002938_white_spotting1.35779457
45MP0001672_abnormal_embryogenesis/_devel1.33489670
46MP0005380_embryogenesis_phenotype1.33489670
47MP0003984_embryonic_growth_retardation1.33143754
48MP0006276_abnormal_autonomic_nervous1.30899179
49MP0008877_abnormal_DNA_methylation1.30884126
50MP0000049_abnormal_middle_ear1.30776135
51MP0002088_abnormal_embryonic_growth/wei1.29718009
52MP0003937_abnormal_limbs/digits/tail_de1.29415362
53MP0002751_abnormal_autonomic_nervous1.27728272
54MP0008995_early_reproductive_senescence1.26502275
55MP0004133_heterotaxia1.25503529
56MP0001697_abnormal_embryo_size1.25026390
57MP0002234_abnormal_pharynx_morphology1.24250562
58MP0008932_abnormal_embryonic_tissue1.22558820
59MP0004233_abnormal_muscle_weight1.22037877
60MP0008007_abnormal_cellular_replicative1.21948734
61MP0000778_abnormal_nervous_system1.21610337
62MP0005075_abnormal_melanosome_morpholog1.21589350
63MP0002932_abnormal_joint_morphology1.21550689
64MP0003119_abnormal_digestive_system1.20698460
65MP0003115_abnormal_respiratory_system1.19822485
66MP0010630_abnormal_cardiac_muscle1.19607928
67MP0004381_abnormal_hair_follicle1.18320962
68MP0005394_taste/olfaction_phenotype1.16927361
69MP0005499_abnormal_olfactory_system1.16927361
70MP0004036_abnormal_muscle_relaxation1.16755043
71MP0005253_abnormal_eye_physiology1.16457872
72MP0001485_abnormal_pinna_reflex1.14794229
73MP0004197_abnormal_fetal_growth/weight/1.13900279
74MP0009053_abnormal_anal_canal1.13055232
75MP0003718_maternal_effect1.10549591
76MP0008961_abnormal_basal_metabolism1.10466071
77MP0004142_abnormal_muscle_tone1.07753126
78MP0000383_abnormal_hair_follicle1.05611571
79MP0003861_abnormal_nervous_system1.05231698
80MP0000490_abnormal_crypts_of1.04200034
81MP0002086_abnormal_extraembryonic_tissu1.03874241
82MP0002095_abnormal_skin_pigmentation1.03164694
83MP0002210_abnormal_sex_determination1.01691938
84MP0005551_abnormal_eye_electrophysiolog1.00825506
85MP0005389_reproductive_system_phenotype1.00345705
86MP0005423_abnormal_somatic_nervous1.00241487
87MP0005391_vision/eye_phenotype0.99677797
88MP0005195_abnormal_posterior_eye0.99392077
89MP0003787_abnormal_imprinting0.99209910
90MP0008775_abnormal_heart_ventricle0.98869881
91MP0000751_myopathy0.98427339
92MP0002080_prenatal_lethality0.97505156
93MP0004808_abnormal_hematopoietic_stem0.97375180
94MP0004087_abnormal_muscle_fiber0.97070367
95MP0002111_abnormal_tail_morphology0.96942920
96MP0001286_abnormal_eye_development0.96036114
97MP0002009_preneoplasia0.95976143
98MP0000749_muscle_degeneration0.93776567
99MP0001145_abnormal_male_reproductive0.92901604
100MP0000462_abnormal_digestive_system0.92535718
101MP0003283_abnormal_digestive_organ0.92209296
102MP0002876_abnormal_thyroid_physiology0.92169296
103MP0002972_abnormal_cardiac_muscle0.91896471
104MP0000266_abnormal_heart_morphology0.91349802
105MP0002396_abnormal_hematopoietic_system0.90050595
106MP0003935_abnormal_craniofacial_develop0.89689702
107MP0001929_abnormal_gametogenesis0.89295403
108MP0005645_abnormal_hypothalamus_physiol0.89061755
109MP0003698_abnormal_male_reproductive0.88254399
110MP0000653_abnormal_sex_gland0.87491915
111MP0003646_muscle_fatigue0.87220817
112MP0004145_abnormal_muscle_electrophysio0.87094717
113MP0004130_abnormal_muscle_cell0.86527063
114MP0006138_congestive_heart_failure0.85088714
115MP0000026_abnormal_inner_ear0.83818456
116MP0003880_abnormal_central_pattern0.83324378
117MP0002697_abnormal_eye_size0.82992545
118MP0002106_abnormal_muscle_physiology0.82058380
119MP0002233_abnormal_nose_morphology0.81558691
120MP0002163_abnormal_gland_morphology0.81481895
121MP0005330_cardiomyopathy0.81029992
122MP0004885_abnormal_endolymph0.80988260
123MP0005220_abnormal_exocrine_pancreas0.79570443
124MP0005620_abnormal_muscle_contractility0.79463132
125MP0002752_abnormal_somatic_nervous0.79016613
126MP0010678_abnormal_skin_adnexa0.78996562
127MP0001346_abnormal_lacrimal_gland0.78292693
128MP0005369_muscle_phenotype0.77895147
129MP0000313_abnormal_cell_death0.77864732
130MP0002116_abnormal_craniofacial_bone0.77578536
131MP0002108_abnormal_muscle_morphology0.77271029
132MP0001119_abnormal_female_reproductive0.76200316
133MP0010352_gastrointestinal_tract_polyps0.76067025
134MP0005385_cardiovascular_system_phenoty0.74572756
135MP0001544_abnormal_cardiovascular_syste0.74572756
136MP0002249_abnormal_larynx_morphology0.74013087
137MP0002114_abnormal_axial_skeleton0.73749541
138MP0003786_premature_aging0.72905853
139MP0002092_abnormal_eye_morphology0.72124869
140MP0002925_abnormal_cardiovascular_devel0.71818662
141MP0002152_abnormal_brain_morphology0.71714745
142MP0002282_abnormal_trachea_morphology0.71621149
143MP0001188_hyperpigmentation0.71338975
144MP0000428_abnormal_craniofacial_morphol0.71215771
145MP0006054_spinal_hemorrhage0.71052360
146MP0009697_abnormal_copulation0.70606687
147MP0002822_catalepsy0.70048703
148MP0002557_abnormal_social/conspecific_i0.69502788
149MP0000372_irregular_coat_pigmentation0.68680942
150MP0000647_abnormal_sebaceous_gland0.68624826
151MP0001919_abnormal_reproductive_system0.68610380

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.89089786
2Poikilocytosis (HP:0004447)5.57332898
3Anomalous pulmonary venous return (HP:0010772)5.36802569
4Rib fusion (HP:0000902)5.02606898
5Abnormality of the pulmonary veins (HP:0011718)4.81071528
6Hypochromic microcytic anemia (HP:0004840)4.56355256
7Acanthocytosis (HP:0001927)3.72638500
8Hemivertebrae (HP:0002937)3.29179338
9Pancreatic cysts (HP:0001737)3.09973932
10Abnormality of the intervertebral disk (HP:0005108)3.09255611
11Diaphragmatic weakness (HP:0009113)3.06035908
12Severe combined immunodeficiency (HP:0004430)2.98000120
13Nephronophthisis (HP:0000090)2.93566286
14Pancreatic fibrosis (HP:0100732)2.88374585
15Ankyloglossia (HP:0010296)2.83983419
16True hermaphroditism (HP:0010459)2.82190496
17Abnormality of midbrain morphology (HP:0002418)2.78126972
18Molar tooth sign on MRI (HP:0002419)2.78126972
19Patellar aplasia (HP:0006443)2.73069522
20Abnormality of B cell number (HP:0010975)2.72446309
21B lymphocytopenia (HP:0010976)2.67084169
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.64136674
23Colon cancer (HP:0003003)2.57001415
24Aplasia/Hypoplasia of the patella (HP:0006498)2.55297741
25Thyroiditis (HP:0100646)2.54748739
26Abnormality of the renal medulla (HP:0100957)2.54339726
27Volvulus (HP:0002580)2.51488649
28Abnormality of the ileum (HP:0001549)2.51397929
29Meckel diverticulum (HP:0002245)2.50294034
30Insomnia (HP:0100785)2.47238105
31Reticulocytosis (HP:0001923)2.45689775
32Pendular nystagmus (HP:0012043)2.43302516
33Obsessive-compulsive behavior (HP:0000722)2.42952139
34Combined immunodeficiency (HP:0005387)2.41835244
35Biliary tract neoplasm (HP:0100574)2.40923339
36Acute lymphatic leukemia (HP:0006721)2.39360970
37Abnormal number of incisors (HP:0011064)2.34699608
38Chronic hepatic failure (HP:0100626)2.33178345
39Disproportionate short-trunk short stature (HP:0003521)2.32801509
40Abnormal number of erythroid precursors (HP:0012131)2.32531671
41Abnormal lung lobation (HP:0002101)2.30581191
42Cholelithiasis (HP:0001081)2.28611242
43Abnormality of chromosome stability (HP:0003220)2.23391911
44Abnormality of reticulocytes (HP:0004312)2.21659812
45Panhypogammaglobulinemia (HP:0003139)2.20889495
46Abnormality of cells of the erythroid lineage (HP:0012130)2.20539362
47Birth length less than 3rd percentile (HP:0003561)2.18294584
48Triphalangeal thumb (HP:0001199)2.18267067
49Congenital stationary night blindness (HP:0007642)2.17710612
50Septo-optic dysplasia (HP:0100842)2.16860051
51Esophageal atresia (HP:0002032)2.15271904
52Ependymoma (HP:0002888)2.13490913
53Absent thumb (HP:0009777)2.10658144
54Pancreatic islet-cell hyperplasia (HP:0004510)2.08704511
55Chromsome breakage (HP:0040012)2.07795423
56Abnormality of the renal collecting system (HP:0004742)2.06923623
57Type II lissencephaly (HP:0007260)2.06629408
58Difficulty running (HP:0009046)2.06555621
59Medulloblastoma (HP:0002885)2.06260291
60Methylmalonic acidemia (HP:0002912)2.05157785
61Neoplasm of the rectum (HP:0100743)2.04689028
62Abnormality of the carotid arteries (HP:0005344)2.04441850
63Neoplasm of the small intestine (HP:0100833)2.03664428
64Short 4th metacarpal (HP:0010044)2.02877897
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02877897
66Pallor (HP:0000980)2.02770408
67Long eyelashes (HP:0000527)2.02025825
68Short middle phalanx of the 5th finger (HP:0004220)2.00613800
69Neoplasm of the adrenal cortex (HP:0100641)1.99920341
70Anterior segment dysgenesis (HP:0007700)1.99139914
71Supernumerary spleens (HP:0009799)1.98776418
72Thyroid-stimulating hormone excess (HP:0002925)1.98540476
73Cystic liver disease (HP:0006706)1.98296611
74Duplicated collecting system (HP:0000081)1.97214457
75Sudden death (HP:0001699)1.96764379
76Abnormality of the renal cortex (HP:0011035)1.96698947
77Abnormal gallbladder morphology (HP:0012437)1.95514576
78Wrist flexion contracture (HP:0001239)1.95370979
79Partial agenesis of the corpus callosum (HP:0001338)1.94436866
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.93035235
81Impulsivity (HP:0100710)1.91273387
82Homocystinuria (HP:0002156)1.90930832
83Abnormality of homocysteine metabolism (HP:0010919)1.90930832
84Hyperalaninemia (HP:0003348)1.89877850
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89877850
86Abnormality of alanine metabolism (HP:0010916)1.89877850
87Sclerocornea (HP:0000647)1.89757898
88Cerebellar dysplasia (HP:0007033)1.89347129
89Medial flaring of the eyebrow (HP:0010747)1.88079600
90Abnormality of chromosome segregation (HP:0002916)1.87977490
91Abnormality of the labia minora (HP:0012880)1.86466881
92Paralysis (HP:0003470)1.86267308
93Osteomalacia (HP:0002749)1.86027814
94Anencephaly (HP:0002323)1.85958217
95Macrocytic anemia (HP:0001972)1.84212220
96Hypoplastic labia majora (HP:0000059)1.84145478
97Increased nuchal translucency (HP:0010880)1.84095267
98Bilateral microphthalmos (HP:0007633)1.82332288
99Sloping forehead (HP:0000340)1.82109682
100Genetic anticipation (HP:0003743)1.80989161
101Abnormality of the preputium (HP:0100587)1.80961712
102Skull defect (HP:0001362)1.80869658
103Spina bifida occulta (HP:0003298)1.80640985
104Chorioretinal atrophy (HP:0000533)1.80432341
105Muscle fiber splitting (HP:0003555)1.80229964
106Aplasia/Hypoplasia of the spleen (HP:0010451)1.79730716
107Maternal diabetes (HP:0009800)1.79102995
108Reticulocytopenia (HP:0001896)1.78939878
109Broad alveolar ridges (HP:0000187)1.78621220
110Nephroblastoma (Wilms tumor) (HP:0002667)1.78153861
111Clubbing of toes (HP:0100760)1.78053993
112Asplenia (HP:0001746)1.78046328
113Meningocele (HP:0002435)1.77909019
114Neoplasm of the pancreas (HP:0002894)1.77660907
115Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77571633
116Renal duplication (HP:0000075)1.77199369
117Muscle hypertrophy of the lower extremities (HP:0008968)1.75642964
118Gastrointestinal carcinoma (HP:0002672)1.74999130
119Malignant gastrointestinal tract tumors (HP:0006749)1.74999130
120Hyponatremia (HP:0002902)1.74967731
121Intestinal atresia (HP:0011100)1.74711581
122Abnormality of oral frenula (HP:0000190)1.73832854
123Abnormality of the duodenum (HP:0002246)1.73443091
124Dandy-Walker malformation (HP:0001305)1.72666497
125Abnormal pancreas size (HP:0012094)1.72592047
126Broad palm (HP:0001169)1.72057426
127Uterine neoplasm (HP:0010784)1.72001487
128Anophthalmia (HP:0000528)1.71632820
129Atrial fibrillation (HP:0005110)1.71458854
130Proximal placement of thumb (HP:0009623)1.70097806
131Rectal prolapse (HP:0002035)1.68941317
132Calf muscle hypertrophy (HP:0008981)1.68917912
133Neoplasm of the colon (HP:0100273)1.68274965
134Preaxial hand polydactyly (HP:0001177)1.68236493
135Abnormality of the left ventricular outflow tract (HP:0011103)1.67486512
136Subaortic stenosis (HP:0001682)1.67486512
137Vertebral fusion (HP:0002948)1.67169741
138Oligodactyly (hands) (HP:0001180)1.66460540
139Abnormality of DNA repair (HP:0003254)1.65636479
140Hyperbilirubinemia (HP:0002904)1.64651347
141Severe short stature (HP:0003510)1.64196385
142Methylmalonic aciduria (HP:0012120)1.63463086
143Ectopic kidney (HP:0000086)1.63449519
144Retinal dysplasia (HP:0007973)1.62980584
145Postaxial foot polydactyly (HP:0001830)1.62691907
146Exercise-induced muscle cramps (HP:0003710)1.62686113
147Selective tooth agenesis (HP:0001592)1.62448838
148Abnormality of the 4th metacarpal (HP:0010012)1.62210245
149Chin dimple (HP:0010751)1.62095609
150Prominent occiput (HP:0000269)1.61642797
151Supraventricular tachycardia (HP:0004755)1.61529340
152Abolished electroretinogram (ERG) (HP:0000550)1.61494932
153Primary atrial arrhythmia (HP:0001692)1.60540320
154Small intestinal stenosis (HP:0012848)1.60524493
155Duodenal stenosis (HP:0100867)1.60524493
156Ovarian neoplasm (HP:0100615)1.60103310
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60041424
158Optic nerve hypoplasia (HP:0000609)1.59933698
159Abnormality of the pons (HP:0007361)1.59695476
160High anterior hairline (HP:0009890)1.59642243
161Congenital hepatic fibrosis (HP:0002612)1.59629818
162Embryonal renal neoplasm (HP:0011794)1.59509602
163Abnormal biliary tract physiology (HP:0012439)1.58860059
164Bile duct proliferation (HP:0001408)1.58860059
165Attenuation of retinal blood vessels (HP:0007843)1.58829644
166Poor coordination (HP:0002370)1.58796692
167Gastrointestinal atresia (HP:0002589)1.58765066
168Abnormality of the labia majora (HP:0012881)1.58666739
169Myelodysplasia (HP:0002863)1.58201761
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.58118010
171Bicornuate uterus (HP:0000813)1.58066567
172Supraventricular arrhythmia (HP:0005115)1.57184181
173Hyporeflexia of lower limbs (HP:0002600)1.57069719
174Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.57064710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.40982251
2FGFR24.39631977
3CDC73.43709306
4BRD43.03795966
5FRK2.88123369
6TLK12.83487977
7NLK2.64682407
8VRK22.64311614
9MELK2.55846186
10EIF2AK12.25598505
11BMPR1B2.22781072
12NEK12.16990550
13ZAK2.11840298
14DYRK32.08150652
15PASK2.04600541
16CAMK1D2.01498492
17BRSK11.97066258
18TAF11.95629878
19PLK41.88739636
20TIE11.84271684
21TGFBR11.79259131
22STK41.77687278
23NEK21.76106907
24ICK1.67732677
25TYRO31.66186508
26MAP4K21.65506784
27PDGFRA1.60665870
28MAP3K41.59724833
29CAMK1G1.58260054
30CDK71.53049000
31MKNK11.52508205
32AURKB1.51873652
33FGFR41.41963660
34WEE11.41610765
35TTK1.41455869
36DYRK21.40012867
37CCNB11.34894218
38SRPK11.29035467
39ADRBK21.25688795
40BCKDK1.24908163
41MAPK131.24496226
42GRK11.23765456
43TTN1.19297602
44CHEK21.18817972
45ATR1.18451917
46BUB11.15904213
47EEF2K1.14171417
48MAPK111.10595894
49FGFR31.09059563
50INSRR1.08717698
51MAP3K101.07138895
52RPS6KB21.05329596
53CDK91.03556069
54NEK61.03430760
55OBSCN1.00391110
56WNK11.00296372
57CHEK10.96687665
58VRK10.94704565
59AURKA0.93557666
60UHMK10.91402727
61TNIK0.88814355
62PLK10.87218693
63CDC42BPA0.86951100
64TAOK30.84078062
65LMTK20.84054300
66FGFR10.83857580
67STK390.83304681
68PNCK0.82824507
69ERBB20.82425995
70RPS6KA50.81710392
71KSR10.81024417
72DMPK0.78744496
73PIK3CA0.78087638
74CDK30.75575090
75PIK3CG0.74827410
76MAP3K80.74261821
77BRSK20.74217715
78MAP3K70.73486076
79PLK30.73260983
80STK100.72304674
81CDK80.72186415
82CDK40.71513885
83CDK190.71111265
84ATM0.70821211
85MTOR0.67786579
86WNK40.67432275
87CDK10.66484391
88TSSK60.64259581
89BCR0.62348773
90YES10.61285943
91ACVR1B0.61008700
92MAP2K70.59805071
93DYRK1A0.58218734
94NTRK20.58010377
95CAMK10.57733829
96EPHB20.57704621
97CSNK1G10.56754765
98CDK20.55408919
99CSNK1D0.54140118
100FLT30.52971159
101PKN20.52961728
102CDK60.52925146
103PINK10.52800756
104OXSR10.52455312
105AKT20.52261950
106STK110.51621883
107CLK10.50884768
108AKT30.50302141
109CAMK40.49987387
110SGK20.49495225
111DYRK1B0.48934686
112RPS6KA60.48084714
113PRKAA10.47849352
114MAPK150.47557811
115STK38L0.47428334
116PDK40.47137135
117PDK30.47137135
118CSNK2A10.46249688
119GSK3B0.45981047
120TEC0.45698713
121STK160.45563320
122EIF2AK20.45355163
123MKNK20.44972292
124LATS10.43678243
125NUAK10.43356975
126PRKDC0.42015246
127WNK30.41583393
128RET0.41300817
129STK30.41297068
130CSNK1E0.41167192
131CSNK1G20.41116386
132NME10.40863627
133SGK2230.40199119
134SGK4940.40199119
135MAP2K20.39872700
136PIM10.39524244
137MAPKAPK50.39262022
138PBK0.39237778
139CSNK2A20.38226484
140ADRBK10.37983380
141PDGFRB0.35902962
142AKT10.35140568
143PAK40.34620638
144PRKAA20.34060180

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.93038611
2DNA replication_Homo sapiens_hsa030303.45535088
3* Cell cycle_Homo sapiens_hsa041103.17116276
4Mismatch repair_Homo sapiens_hsa034302.94497809
5Notch signaling pathway_Homo sapiens_hsa043302.78968837
6Non-homologous end-joining_Homo sapiens_hsa034502.61178412
7Spliceosome_Homo sapiens_hsa030402.48159994
8Base excision repair_Homo sapiens_hsa034102.28700290
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.24619557
10Alcoholism_Homo sapiens_hsa050342.14074758
11Homologous recombination_Homo sapiens_hsa034402.09700760
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87626564
13Nucleotide excision repair_Homo sapiens_hsa034201.85655042
14RNA transport_Homo sapiens_hsa030131.83424441
15Fanconi anemia pathway_Homo sapiens_hsa034601.79411925
16Ribosome_Homo sapiens_hsa030101.76481802
17Oxidative phosphorylation_Homo sapiens_hsa001901.76402059
18Phototransduction_Homo sapiens_hsa047441.71169786
19mRNA surveillance pathway_Homo sapiens_hsa030151.68821385
20Basal cell carcinoma_Homo sapiens_hsa052171.63241949
21RNA degradation_Homo sapiens_hsa030181.55300926
22Nitrogen metabolism_Homo sapiens_hsa009101.52886872
23Non-small cell lung cancer_Homo sapiens_hsa052231.52082016
24One carbon pool by folate_Homo sapiens_hsa006701.50486926
25Lysine degradation_Homo sapiens_hsa003101.45133178
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43991107
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43147408
28Propanoate metabolism_Homo sapiens_hsa006401.42432944
29Viral carcinogenesis_Homo sapiens_hsa052031.39011693
30Butanoate metabolism_Homo sapiens_hsa006501.38077642
31RNA polymerase_Homo sapiens_hsa030201.37197018
32MicroRNAs in cancer_Homo sapiens_hsa052061.36357810
33Vitamin B6 metabolism_Homo sapiens_hsa007501.34187970
34Small cell lung cancer_Homo sapiens_hsa052221.28285152
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27731820
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26423885
37Primary immunodeficiency_Homo sapiens_hsa053401.23140418
38Pyrimidine metabolism_Homo sapiens_hsa002401.22100251
39Chronic myeloid leukemia_Homo sapiens_hsa052201.13299455
40Linoleic acid metabolism_Homo sapiens_hsa005911.09488733
41Hippo signaling pathway_Homo sapiens_hsa043901.07827137
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06508795
43p53 signaling pathway_Homo sapiens_hsa041151.05161734
44Hedgehog signaling pathway_Homo sapiens_hsa043401.04610660
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01705430
46Pyruvate metabolism_Homo sapiens_hsa006200.97019244
47Bladder cancer_Homo sapiens_hsa052190.96854980
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94235563
49Alzheimers disease_Homo sapiens_hsa050100.94058136
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94021865
51Oocyte meiosis_Homo sapiens_hsa041140.93251417
52Protein export_Homo sapiens_hsa030600.92782975
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90617036
54TGF-beta signaling pathway_Homo sapiens_hsa043500.90413710
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89757450
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89391343
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88511583
58Olfactory transduction_Homo sapiens_hsa047400.87701632
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86822124
60Purine metabolism_Homo sapiens_hsa002300.86783784
61Carbon metabolism_Homo sapiens_hsa012000.86141423
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83455593
63Nicotine addiction_Homo sapiens_hsa050330.81942941
64Tryptophan metabolism_Homo sapiens_hsa003800.81859488
65Taste transduction_Homo sapiens_hsa047420.79489333
66Wnt signaling pathway_Homo sapiens_hsa043100.79214956
67Basal transcription factors_Homo sapiens_hsa030220.79179404
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77054731
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.74201778
70Tight junction_Homo sapiens_hsa045300.72671529
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72259807
72Melanoma_Homo sapiens_hsa052180.72039152
73Prostate cancer_Homo sapiens_hsa052150.71630911
74Glioma_Homo sapiens_hsa052140.70617649
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70531950
76Cardiac muscle contraction_Homo sapiens_hsa042600.70526942
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69951288
78Pathways in cancer_Homo sapiens_hsa052000.69174662
79Pancreatic secretion_Homo sapiens_hsa049720.68861156
80HTLV-I infection_Homo sapiens_hsa051660.68322096
81Selenocompound metabolism_Homo sapiens_hsa004500.68254969
82Dilated cardiomyopathy_Homo sapiens_hsa054140.68203040
83Caffeine metabolism_Homo sapiens_hsa002320.67684348
84Colorectal cancer_Homo sapiens_hsa052100.66911983
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66157846
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64839683
87Protein digestion and absorption_Homo sapiens_hsa049740.64575615
88AMPK signaling pathway_Homo sapiens_hsa041520.64256659
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63870747
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63536333
91Fatty acid degradation_Homo sapiens_hsa000710.62949622
92Thyroid cancer_Homo sapiens_hsa052160.62654595
93Inositol phosphate metabolism_Homo sapiens_hsa005620.60953707
94Biosynthesis of amino acids_Homo sapiens_hsa012300.60618285
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59286458
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58974325
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58936342
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.58304080
99Adherens junction_Homo sapiens_hsa045200.57137177
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.56827804
101Peroxisome_Homo sapiens_hsa041460.55452042
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.54741110
103Dorso-ventral axis formation_Homo sapiens_hsa043200.54503321
104Retinol metabolism_Homo sapiens_hsa008300.52272336
105Vitamin digestion and absorption_Homo sapiens_hsa049770.51250522
106Ether lipid metabolism_Homo sapiens_hsa005650.49699597
107Regulation of autophagy_Homo sapiens_hsa041400.49250009
108Pancreatic cancer_Homo sapiens_hsa052120.49105744
109Renal cell carcinoma_Homo sapiens_hsa052110.48828960
110FoxO signaling pathway_Homo sapiens_hsa040680.48102867
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47870034
112Fat digestion and absorption_Homo sapiens_hsa049750.47180489
113Proteasome_Homo sapiens_hsa030500.46844527
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46773427
115Endometrial cancer_Homo sapiens_hsa052130.46321544
116HIF-1 signaling pathway_Homo sapiens_hsa040660.45301307
117Huntingtons disease_Homo sapiens_hsa050160.44398654
118Parkinsons disease_Homo sapiens_hsa050120.44334077
119Fatty acid metabolism_Homo sapiens_hsa012120.44088973
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43172637
121Proteoglycans in cancer_Homo sapiens_hsa052050.42183943
122Chemical carcinogenesis_Homo sapiens_hsa052040.41833059
123Melanogenesis_Homo sapiens_hsa049160.40167428
124Metabolic pathways_Homo sapiens_hsa011000.40072618
125Epstein-Barr virus infection_Homo sapiens_hsa051690.39834697
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.39119583
127Glycerolipid metabolism_Homo sapiens_hsa005610.38571398
128ErbB signaling pathway_Homo sapiens_hsa040120.34753175
129Morphine addiction_Homo sapiens_hsa050320.34504067
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34383451
131Choline metabolism in cancer_Homo sapiens_hsa052310.33630301
132Calcium signaling pathway_Homo sapiens_hsa040200.33103665
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32331262
134Insulin signaling pathway_Homo sapiens_hsa049100.32213217
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32187148
136Folate biosynthesis_Homo sapiens_hsa007900.32172610
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31442728
138Serotonergic synapse_Homo sapiens_hsa047260.30553332
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30173601
140Fatty acid elongation_Homo sapiens_hsa000620.29648901
141Sulfur relay system_Homo sapiens_hsa041220.29195228
142Cholinergic synapse_Homo sapiens_hsa047250.28998033
143Circadian rhythm_Homo sapiens_hsa047100.28704542

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