TFDP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)8.23473076
2urea metabolic process (GO:0019627)7.73923556
3phenylpropanoid metabolic process (GO:0009698)7.58892569
4urea cycle (GO:0000050)7.36948395
5peptidyl-glutamic acid carboxylation (GO:0017187)7.09614961
6protein carboxylation (GO:0018214)7.09614961
7regulation of bile acid biosynthetic process (GO:0070857)7.01672948
8nitrogen cycle metabolic process (GO:0071941)6.95424149
9oxidative demethylation (GO:0070989)6.87049563
10bile acid biosynthetic process (GO:0006699)6.66393542
11blood coagulation, intrinsic pathway (GO:0007597)6.34619757
12regulation of protein activation cascade (GO:2000257)6.15978385
13regulation of fibrinolysis (GO:0051917)6.07821291
14drug catabolic process (GO:0042737)6.02033527
15serine family amino acid catabolic process (GO:0009071)5.87130354
16sulfur amino acid catabolic process (GO:0000098)5.85877282
17sterol catabolic process (GO:0016127)5.70809725
18cholesterol catabolic process (GO:0006707)5.70809725
19L-phenylalanine catabolic process (GO:0006559)5.67051220
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.67051220
21steroid catabolic process (GO:0006706)5.58633291
22complement activation, alternative pathway (GO:0006957)5.41406370
23regulation of complement activation (GO:0030449)5.39674737
24epoxygenase P450 pathway (GO:0019373)5.36213428
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.33713334
26L-phenylalanine metabolic process (GO:0006558)5.33713334
27bile acid metabolic process (GO:0008206)5.31268381
28regulation of triglyceride catabolic process (GO:0010896)5.27931530
29drug metabolic process (GO:0017144)5.24994265
30arginine metabolic process (GO:0006525)5.21562141
31glycine metabolic process (GO:0006544)5.10679939
32negative regulation of fibrinolysis (GO:0051918)5.09194284
33alkaloid metabolic process (GO:0009820)5.02481684
34fibrinolysis (GO:0042730)4.80207808
35piRNA metabolic process (GO:0034587)4.76653043
36male meiosis I (GO:0007141)4.74155582
37omega-hydroxylase P450 pathway (GO:0097267)4.64312812
38triglyceride homeostasis (GO:0070328)4.55600208
39acylglycerol homeostasis (GO:0055090)4.55600208
40synapsis (GO:0007129)4.53269991
41hormone catabolic process (GO:0042447)4.42452389
42cellular glucuronidation (GO:0052695)4.42327937
43serine family amino acid metabolic process (GO:0009069)4.35192987
44glucuronate metabolic process (GO:0019585)4.26925483
45uronic acid metabolic process (GO:0006063)4.26925483
46cysteine metabolic process (GO:0006534)4.25109134
47serine family amino acid biosynthetic process (GO:0009070)4.07541438
48gap junction assembly (GO:0016264)4.04144227
49amino-acid betaine metabolic process (GO:0006577)4.03337739
50bile acid and bile salt transport (GO:0015721)3.94383068
51response to vitamin A (GO:0033189)3.93690571
52meiosis I (GO:0007127)3.84990516
53ethanol oxidation (GO:0006069)3.82214857
54male meiosis (GO:0007140)3.81390942
55gonadal mesoderm development (GO:0007506)3.81088704
56diterpenoid biosynthetic process (GO:0016102)3.80553968
57negative regulation of blood coagulation (GO:0030195)3.73403735
58negative regulation of hemostasis (GO:1900047)3.73403735
59proline metabolic process (GO:0006560)3.67425258
60aromatic amino acid family catabolic process (GO:0009074)3.61730017
61cellular response to cholesterol (GO:0071397)3.60173894
62purine ribonucleotide transport (GO:0015868)3.59059758
63negative regulation of wound healing (GO:0061045)3.57374904
64chromosome organization involved in meiosis (GO:0070192)3.56694424
65protein activation cascade (GO:0072376)3.54550957
66midgut development (GO:0007494)3.45956079
67positive regulation of lipoprotein lipase activity (GO:0051006)3.45725834
68positive regulation of triglyceride lipase activity (GO:0061365)3.45725834
69ethanol metabolic process (GO:0006067)3.44295533
70cofactor catabolic process (GO:0051187)3.41389626
71regulation of plasminogen activation (GO:0010755)3.38692912
72drug transmembrane transport (GO:0006855)3.37806571
73glutamine family amino acid biosynthetic process (GO:0009084)3.36181591
74alpha-amino acid catabolic process (GO:1901606)3.35888799
75negative regulation of coagulation (GO:0050819)3.35062749
76regulation of meiosis I (GO:0060631)3.34142234
77citrulline biosynthetic process (GO:0019240)3.34088559
78acute-phase response (GO:0006953)3.31112677
79negative regulation of complement activation (GO:0045916)3.28606686
80peptidyl-glutamic acid modification (GO:0018200)3.26341273
81exogenous drug catabolic process (GO:0042738)3.26173573
82regulation of cholesterol esterification (GO:0010872)3.25468703
83retinal metabolic process (GO:0042574)3.24013533
84carnitine metabolic process (GO:0009437)3.21895548
85regulation of humoral immune response (GO:0002920)3.21458073
86cholesterol efflux (GO:0033344)3.19967368
87DNA methylation involved in gamete generation (GO:0043046)3.19877298
88heme transport (GO:0015886)3.18369996
89synaptonemal complex assembly (GO:0007130)3.18309776
90negative regulation of protein activation cascade (GO:2000258)3.16729967
91arginine catabolic process (GO:0006527)3.16544069
92cellular amino acid catabolic process (GO:0009063)3.10378999
93acute inflammatory response (GO:0002526)3.09256461
94flavonoid metabolic process (GO:0009812)3.09081891
95L-serine metabolic process (GO:0006563)3.08414303
96tyrosine metabolic process (GO:0006570)3.08382462
97meiotic nuclear division (GO:0007126)3.07401375
98very-low-density lipoprotein particle assembly (GO:0034379)3.07308578
99complement activation (GO:0006956)3.04949673
100response to phenylpropanoid (GO:0080184)3.04584135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.97173892
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.44671032
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.10663225
4CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.24743162
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.16430932
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.66986211
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.59249592
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.43985580
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.42682899
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.09880728
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.91397559
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.91397559
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.91397559
14HTT_18923047_ChIP-ChIP_STHdh_Human2.48138392
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.21680543
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.93361798
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79621438
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77380147
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63518961
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60111393
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53473876
22ERA_21632823_ChIP-Seq_H3396_Human1.48868587
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47784133
24HNF4A_19822575_ChIP-Seq_HepG2_Human1.46057781
25IGF1R_20145208_ChIP-Seq_DFB_Human1.44482276
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44388353
27ZNF274_21170338_ChIP-Seq_K562_Hela1.42494890
28RXRA_24833708_ChIP-Seq_LIVER_Mouse1.38456296
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.34411893
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29478879
31SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28604326
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27816684
33KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24755417
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18612720
35RNF2_27304074_Chip-Seq_NSC_Mouse1.18258484
36RAC3_21632823_ChIP-Seq_H3396_Human1.14260752
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12369158
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.08985565
39PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08865753
40AR_20517297_ChIP-Seq_VCAP_Human1.08548652
41CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07769146
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.07660168
43NCOR_22424771_ChIP-Seq_293T_Human1.05679735
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.05042202
45BCAT_22108803_ChIP-Seq_LS180_Human1.04712196
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.03818997
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.03608799
48TP53_22573176_ChIP-Seq_HFKS_Human1.02154117
49ER_23166858_ChIP-Seq_MCF-7_Human1.00906049
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.00014003
51IRF1_19129219_ChIP-ChIP_H3396_Human0.99592521
52NOTCH1_21737748_ChIP-Seq_TLL_Human0.99476013
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98239075
54PHF8_20622853_ChIP-Seq_HELA_Human0.95425644
55SOX2_21211035_ChIP-Seq_LN229_Human0.95309454
56E2F1_20622854_ChIP-Seq_HELA_Human0.92895601
57GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92191851
58HNFA_21074721_ChIP-Seq_CACO-2_Human0.92072387
59EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91795248
60STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91741932
61MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89458480
62P53_21459846_ChIP-Seq_SAOS-2_Human0.89128485
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88692210
64BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86646102
65SALL1_21062744_ChIP-ChIP_HESCs_Human0.85542322
66CTCF_20526341_ChIP-Seq_ESCs_Human0.85307657
67SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.85192397
68AR_21909140_ChIP-Seq_LNCAP_Human0.85001906
69ETS1_20019798_ChIP-Seq_JURKAT_Human0.84848358
70GATA6_21074721_ChIP-Seq_CACO-2_Human0.84388208
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84304920
72NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83797588
73MYC_18555785_ChIP-Seq_MESCs_Mouse0.82601769
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82576749
75EZH2_27294783_Chip-Seq_NPCs_Mouse0.80865002
76HOXB7_26014856_ChIP-Seq_BT474_Human0.79736094
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78482937
78E2F7_22180533_ChIP-Seq_HELA_Human0.77227061
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77216922
80RBPJ_21746931_ChIP-Seq_IB4_Human0.76825362
81GABP_19822575_ChIP-Seq_HepG2_Human0.76790383
82DCP1A_22483619_ChIP-Seq_HELA_Human0.76609984
83ESR1_20079471_ChIP-ChIP_T-47D_Human0.76414761
84TAF2_19829295_ChIP-Seq_ESCs_Human0.76294542
85ETV1_20927104_ChIP-Seq_GIST48_Human0.75332817
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74554808
87CBX2_22325352_ChIP-Seq_293T-Rex_Human0.73795655
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72941836
89GATA3_26560356_Chip-Seq_TH1_Human0.72792356
90* FOXA1_25329375_ChIP-Seq_VCAP_Human0.72192039
91* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72192039
92MYC_19829295_ChIP-Seq_ESCs_Human0.70586354
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70384414
94MYCN_18555785_ChIP-Seq_MESCs_Mouse0.69458700
95* P300_27268052_Chip-Seq_Bcells_Human0.69225595
96* FOXH1_21741376_ChIP-Seq_EPCs_Human0.68868044
97E2F1_18555785_ChIP-Seq_MESCs_Mouse0.68655202
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.67622404
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.67442121
100POU5F1_16518401_ChIP-PET_MESCs_Mouse0.66990609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.39467255
2MP0002139_abnormal_hepatobiliary_system6.24288717
3MP0005085_abnormal_gallbladder_physiolo5.89096147
4MP0003868_abnormal_feces_composition5.37004578
5MP0005365_abnormal_bile_salt5.15800011
6MP0009697_abnormal_copulation5.09161758
7MP0002138_abnormal_hepatobiliary_system4.65058137
8MP0008875_abnormal_xenobiotic_pharmacok4.12513963
9MP0003806_abnormal_nucleotide_metabolis3.73268818
10MP0003195_calcinosis3.59284529
11MP0001666_abnormal_nutrient_absorption3.18264629
12MP0004019_abnormal_vitamin_homeostasis2.63677465
13MP0003252_abnormal_bile_duct2.44079246
14MP0001764_abnormal_homeostasis2.34503090
15MP0008877_abnormal_DNA_methylation2.24227821
16MP0005187_abnormal_penis_morphology2.06890526
17MP0002876_abnormal_thyroid_physiology1.88654252
18MP0002163_abnormal_gland_morphology1.82011931
19MP0010368_abnormal_lymphatic_system1.64788804
20MP0010329_abnormal_lipoprotein_level1.62024496
21MP0002090_abnormal_vision1.58863934
22MP0003646_muscle_fatigue1.51308061
23MP0005332_abnormal_amino_acid1.43482983
24MP0003186_abnormal_redox_activity1.38505384
25MP0009053_abnormal_anal_canal1.27249238
26MP0010386_abnormal_urinary_bladder1.25655676
27MP0005623_abnormal_meninges_morphology1.15426554
28MP0002210_abnormal_sex_determination1.14678025
29MP0002160_abnormal_reproductive_system1.11526740
30MP0008058_abnormal_DNA_repair1.11206877
31MP0001929_abnormal_gametogenesis1.10142328
32MP0000609_abnormal_liver_physiology1.09734395
33MP0003693_abnormal_embryo_hatching1.03921148
34MP0002118_abnormal_lipid_homeostasis1.02617907
35MP0005646_abnormal_pituitary_gland0.98218161
36MP0001986_abnormal_taste_sensitivity0.97788628
37MP0005379_endocrine/exocrine_gland_phen0.96715415
38MP0009672_abnormal_birth_weight0.96387918
39MP0009840_abnormal_foam_cell0.93207865
40MP0001915_intracranial_hemorrhage0.92425303
41MP0003698_abnormal_male_reproductive0.90789782
42MP0002249_abnormal_larynx_morphology0.88737520
43MP0000653_abnormal_sex_gland0.87134727
44MP0005636_abnormal_mineral_homeostasis0.87122063
45MP0001145_abnormal_male_reproductive0.86312625
46MP0006036_abnormal_mitochondrial_physio0.85565436
47MP0005319_abnormal_enzyme/_coenzyme0.83242479
48MP0003718_maternal_effect0.80775994
49MP0000598_abnormal_liver_morphology0.79733767
50MP0006292_abnormal_olfactory_placode0.75141145
51MP0008872_abnormal_physiological_respon0.74447395
52MP0001346_abnormal_lacrimal_gland0.74195601
53MP0005395_other_phenotype0.73129494
54MP0002089_abnormal_postnatal_growth/wei0.71513341
55MP0001440_abnormal_grooming_behavior0.67993145
56MP0005376_homeostasis/metabolism_phenot0.66434728
57MP0005058_abnormal_lysosome_morphology0.65229837
58MP0003183_abnormal_peptide_metabolism0.63834165
59MP0002161_abnormal_fertility/fecundity0.63053021
60MP0003111_abnormal_nucleus_morphology0.58393792
61MP0002234_abnormal_pharynx_morphology0.55057563
62MP0003699_abnormal_female_reproductive0.52042391
63MP0005410_abnormal_fertilization0.51267271
64MP0005389_reproductive_system_phenotype0.48886206
65MP0001661_extended_life_span0.47592796
66MP0009642_abnormal_blood_homeostasis0.47311290
67MP0000678_abnormal_parathyroid_gland0.46816494
68MP0003191_abnormal_cellular_cholesterol0.44866600
69MP0001730_embryonic_growth_arrest0.44346994
70MP0009643_abnormal_urine_homeostasis0.43944663
71MP0003123_paternal_imprinting0.43534739
72MP0002282_abnormal_trachea_morphology0.43189223
73MP0000427_abnormal_hair_cycle0.42902881
74MP0001243_abnormal_dermal_layer0.42629601
75MP0009379_abnormal_foot_pigmentation0.41763204
76MP0000647_abnormal_sebaceous_gland0.41738080
77MP0004957_abnormal_blastocyst_morpholog0.41475437
78MP0003959_abnormal_lean_body0.41342956
79MP0002697_abnormal_eye_size0.40523509
80MP0004233_abnormal_muscle_weight0.40135599
81MP0005670_abnormal_white_adipose0.39968785
82MP0002938_white_spotting0.38909510
83MP0000462_abnormal_digestive_system0.38655785
84MP0008873_increased_physiological_sensi0.38556211
85MP0002132_abnormal_respiratory_system0.37919267
86MP0005584_abnormal_enzyme/coenzyme_acti0.37496853
87MP0003638_abnormal_response/metabolism_0.35912282
88MP0004782_abnormal_surfactant_physiolog0.35718352
89MP0009250_abnormal_appendicular_skeleto0.35644407
90MP0001502_abnormal_circadian_rhythm0.35565995
91MP0004885_abnormal_endolymph0.34794505
92MP0001119_abnormal_female_reproductive0.34592750
93MP0006035_abnormal_mitochondrial_morpho0.33679050
94MP0009333_abnormal_splenocyte_physiolog0.33636998
95MP0005647_abnormal_sex_gland0.33043947
96MP0001188_hyperpigmentation0.32911745
97MP0003937_abnormal_limbs/digits/tail_de0.32660153
98MP0005535_abnormal_body_temperature0.32521801
99MP0008874_decreased_physiological_sensi0.32110643
100MP0001879_abnormal_lymphatic_vessel0.32059458

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)8.42849989
2Prolonged partial thromboplastin time (HP:0003645)8.39470715
3Osteomalacia (HP:0002749)5.68426546
4Hypobetalipoproteinemia (HP:0003563)5.62696838
5Abnormality of pyrimidine metabolism (HP:0004353)5.61528949
6Reduced antithrombin III activity (HP:0001976)5.41011396
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.87766537
8Intrahepatic cholestasis (HP:0001406)4.41878743
9Joint hemorrhage (HP:0005261)4.28990174
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.22936328
11Hyperlipoproteinemia (HP:0010980)4.12494271
12Systemic lupus erythematosus (HP:0002725)4.11406573
13Birth length less than 3rd percentile (HP:0003561)3.99681898
14Complement deficiency (HP:0004431)3.81573058
15Generalized aminoaciduria (HP:0002909)3.63686283
16Hyperammonemia (HP:0001987)3.40259085
17Abnormality of serum amino acid levels (HP:0003112)3.24892823
18Fair hair (HP:0002286)3.14846215
19Hyperglycinemia (HP:0002154)3.03155234
20Abnormality of nucleobase metabolism (HP:0010932)3.00399085
21Spontaneous abortion (HP:0005268)2.94241930
22Abnormality of complement system (HP:0005339)2.78047920
23Xanthomatosis (HP:0000991)2.76462658
24Hypolipoproteinemia (HP:0010981)2.74850716
25Septate vagina (HP:0001153)2.67342918
26Delayed CNS myelination (HP:0002188)2.67257871
27Abnormality of serine family amino acid metabolism (HP:0010894)2.64663590
28Abnormality of glycine metabolism (HP:0010895)2.64663590
29Metabolic acidosis (HP:0001942)2.58642149
30Lower limb hyperreflexia (HP:0002395)2.56698404
31Abnormality of urine glucose concentration (HP:0011016)2.55496683
32Glycosuria (HP:0003076)2.55496683
33Hyperglycinuria (HP:0003108)2.55343342
34Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52646910
35Rickets (HP:0002748)2.51483676
36Irritability (HP:0000737)2.46210162
37Glomerulonephritis (HP:0000099)2.41337331
38Abnormality of the Achilles tendon (HP:0005109)2.40846958
39Proximal tubulopathy (HP:0000114)2.38579540
40Abnormality of the phalanges of the hallux (HP:0010057)2.36765876
41Hyperphosphaturia (HP:0003109)2.31582293
42Abnormal pupillary function (HP:0007686)2.31166695
43Abnormality of the common coagulation pathway (HP:0010990)2.30635052
44Elevated alkaline phosphatase (HP:0003155)2.27510225
45Abnormal biliary tract physiology (HP:0012439)2.25232274
46Bile duct proliferation (HP:0001408)2.25232274
47Abnormality of alanine metabolism (HP:0010916)2.24879156
48Hyperalaninemia (HP:0003348)2.24879156
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24879156
50Abnormality of the intrinsic pathway (HP:0010989)2.22349053
51Alkalosis (HP:0001948)2.22300216
52Abnormality of alkaline phosphatase activity (HP:0004379)2.22172836
53Cholecystitis (HP:0001082)2.21062208
54Abnormal gallbladder physiology (HP:0012438)2.21062208
55Retinal atrophy (HP:0001105)2.20800397
56Purpura (HP:0000979)2.19146869
57Cerebral edema (HP:0002181)2.18805939
58Abnormal enzyme/coenzyme activity (HP:0012379)2.15190072
59Conjugated hyperbilirubinemia (HP:0002908)2.14191622
60Generalized hypopigmentation of hair (HP:0011358)2.13125579
61Abnormal urine phosphate concentration (HP:0012599)2.13051930
62Increased serum ferritin (HP:0003281)2.11743675
63Fat malabsorption (HP:0002630)2.10089665
64Abnormal protein glycosylation (HP:0012346)2.10074840
65Abnormal glycosylation (HP:0012345)2.10074840
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10074840
67Abnormal protein N-linked glycosylation (HP:0012347)2.10074840
68Amblyopia (HP:0000646)2.07791632
69Lethargy (HP:0001254)2.03001015
70Decreased subcutaneous fat (HP:0001002)2.02675327
71Menorrhagia (HP:0000132)2.01041409
72Deep venous thrombosis (HP:0002625)10.5586360
73Pulmonary embolism (HP:0002204)1.94651612
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89128081
75Abnormality of the lower motor neuron (HP:0002366)1.89073033
76Type I transferrin isoform profile (HP:0003642)1.88822212
77Abnormality of the aortic arch (HP:0012303)1.87686067
78Achilles tendon contracture (HP:0001771)1.87156552
79Breast hypoplasia (HP:0003187)1.84769844
80Hyperventilation (HP:0002883)1.82512697
81Wrist flexion contracture (HP:0001239)1.81829845
82Nonimmune hydrops fetalis (HP:0001790)1.81038970
83Abnormality of purine metabolism (HP:0004352)1.80714565
84Diastasis recti (HP:0001540)1.77910698
85Hypophosphatemia (HP:0002148)1.75809318
86Arthropathy (HP:0003040)1.75089224
87Hypoalphalipoproteinemia (HP:0003233)1.74053557
88Atrioventricular block (HP:0001678)1.73896718
89Morphological abnormality of the inner ear (HP:0011390)1.73624788
90Widely patent fontanelles and sutures (HP:0004492)1.72978182
91Abnormality of methionine metabolism (HP:0010901)1.69825044
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.69216949
93Hepatocellular carcinoma (HP:0001402)1.68997442
94Upper motor neuron abnormality (HP:0002127)1.67994076
95Cholelithiasis (HP:0001081)1.66464567
96Abnormality of iron homeostasis (HP:0011031)1.66359215
97Transposition of the great arteries (HP:0001669)1.65965676
98Abnormal connection of the cardiac segments (HP:0011545)1.65965676
99Abnormal ventriculo-arterial connection (HP:0011563)1.65965676
100Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64278234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.46957840
2TLK13.43621741
3PBK2.98187020
4ACVR1B2.72057457
5MET2.71021406
6EPHA42.29148699
7BMX2.23814034
8NEK12.15551134
9PDK22.12150382
10TTK2.01919664
11CDK191.99599349
12BCKDK1.94422625
13ZAK1.91922009
14CAMK1G1.81668516
15FRK1.72246788
16PLK11.69453735
17BRAF1.67541566
18PLK41.64259293
19WEE11.62911558
20STK161.59360937
21CDK41.55504354
22CDK121.52822814
23PTK2B1.48023165
24CDK81.44770619
25BRSK11.42339916
26KDR1.40432189
27NME21.38296311
28NEK91.37168611
29INSRR1.33490464
30FGR1.32781869
31TAOK21.30815297
32AURKA1.26047894
33OXSR11.24230455
34ADRBK21.22141143
35PRPF4B1.16928467
36BUB11.14973454
37CHEK21.13309177
38CDK71.12845102
39EIF2AK31.12023142
40PRKCG1.11846229
41NEK21.07646826
42BRSK21.06732605
43CSF1R1.02876194
44MAP3K91.02672330
45ARAF0.98878325
46MAP2K40.98151808
47PRKCI0.96289826
48MAP2K30.88522395
49ATR0.85585446
50ABL20.85374834
51CDC70.82462928
52TAOK30.75342080
53MAPK110.75048869
54PLK20.74336193
55MUSK0.73454956
56SRPK10.73361733
57KSR20.71168467
58PRKACG0.68779307
59NTRK30.68603932
60TYRO30.68560288
61PLK30.68139132
62MAP3K80.66185622
63CSNK1G20.66097461
64CSNK2A10.65238955
65CCNB10.64430808
66MAP2K20.64188313
67WNK40.62978541
68STK40.62565031
69CHEK10.60149517
70PRKG10.59355902
71CASK0.58511309
72SGK10.56782709
73WNK30.54884243
74PINK10.54586629
75DYRK30.54283718
76RPS6KB10.53997014
77GRK10.53266602
78MAP3K100.53110627
79AKT20.51298627
80ADRBK10.49468077
81CSNK1D0.47271345
82MAP3K20.46467963
83CDK60.46393413
84PRKACA0.46198159
85PTK20.45377756
86AURKB0.44386343
87MARK30.44041622
88ILK0.42865629
89CSNK1G30.42696591
90CSNK1G10.42236715
91STK38L0.40788597
92ATM0.40543013
93PDGFRB0.39809064
94CSNK2A20.39675222
95STK110.38740624
96CDK10.35859424
97STK390.35679501
98PRKCA0.34561536
99MST1R0.33636452
100EIF2AK10.33421766

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001205.66321891
2Complement and coagulation cascades_Homo sapiens_hsa046103.47323509
3Arginine biosynthesis_Homo sapiens_hsa002203.38301503
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.30309598
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.14296904
6Steroid hormone biosynthesis_Homo sapiens_hsa001403.10626460
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09535084
8Sulfur relay system_Homo sapiens_hsa041222.95305594
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.78725667
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67670643
11Retinol metabolism_Homo sapiens_hsa008302.64857468
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.60791958
13Chemical carcinogenesis_Homo sapiens_hsa052042.44531039
14Sulfur metabolism_Homo sapiens_hsa009202.34886479
15Phenylalanine metabolism_Homo sapiens_hsa003602.27252062
16Bile secretion_Homo sapiens_hsa049762.18025025
17Linoleic acid metabolism_Homo sapiens_hsa005912.04115365
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.93221994
19Histidine metabolism_Homo sapiens_hsa003401.83864768
20Peroxisome_Homo sapiens_hsa041461.80546071
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74170603
22Tyrosine metabolism_Homo sapiens_hsa003501.69666144
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.64365669
24Fatty acid degradation_Homo sapiens_hsa000711.54204624
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49447038
26Tryptophan metabolism_Homo sapiens_hsa003801.47093764
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.43386826
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38866868
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38293318
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36060033
31PPAR signaling pathway_Homo sapiens_hsa033201.29887923
32Arginine and proline metabolism_Homo sapiens_hsa003301.27075199
33beta-Alanine metabolism_Homo sapiens_hsa004101.25945693
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20111826
35Arachidonic acid metabolism_Homo sapiens_hsa005901.18920078
36Starch and sucrose metabolism_Homo sapiens_hsa005001.18612522
37Biosynthesis of amino acids_Homo sapiens_hsa012301.17775391
38One carbon pool by folate_Homo sapiens_hsa006701.15012755
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10016224
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09187101
41Pyruvate metabolism_Homo sapiens_hsa006200.96892302
42Caffeine metabolism_Homo sapiens_hsa002320.94598301
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93717276
44Fatty acid elongation_Homo sapiens_hsa000620.89474367
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.85556277
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84451503
47Vitamin B6 metabolism_Homo sapiens_hsa007500.83831701
48Carbon metabolism_Homo sapiens_hsa012000.83505400
49Folate biosynthesis_Homo sapiens_hsa007900.79560443
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78760109
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76462460
52Butanoate metabolism_Homo sapiens_hsa006500.75794728
53Prion diseases_Homo sapiens_hsa050200.71859235
54Mismatch repair_Homo sapiens_hsa034300.69208878
55Basal transcription factors_Homo sapiens_hsa030220.66907733
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62341807
57Homologous recombination_Homo sapiens_hsa034400.61672114
58Metabolic pathways_Homo sapiens_hsa011000.58846997
59Fat digestion and absorption_Homo sapiens_hsa049750.57897957
60Propanoate metabolism_Homo sapiens_hsa006400.51758138
61DNA replication_Homo sapiens_hsa030300.50011675
62Lysine degradation_Homo sapiens_hsa003100.49183607
63Pentose phosphate pathway_Homo sapiens_hsa000300.48735642
64Base excision repair_Homo sapiens_hsa034100.47442802
65Regulation of autophagy_Homo sapiens_hsa041400.42494278
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42439364
67Fructose and mannose metabolism_Homo sapiens_hsa000510.40991754
68Glutathione metabolism_Homo sapiens_hsa004800.38352511
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38174223
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.36506736
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36098924
72Steroid biosynthesis_Homo sapiens_hsa001000.35203502
73RNA polymerase_Homo sapiens_hsa030200.34288316
74Nucleotide excision repair_Homo sapiens_hsa034200.33762355
75N-Glycan biosynthesis_Homo sapiens_hsa005100.32447369
76ABC transporters_Homo sapiens_hsa020100.31180132
77Fatty acid metabolism_Homo sapiens_hsa012120.27249818
78Staphylococcus aureus infection_Homo sapiens_hsa051500.26718042
79RNA transport_Homo sapiens_hsa030130.21291657
80Selenocompound metabolism_Homo sapiens_hsa004500.20889527
81Pyrimidine metabolism_Homo sapiens_hsa002400.20768049
82Vitamin digestion and absorption_Homo sapiens_hsa049770.20432927
83Fanconi anemia pathway_Homo sapiens_hsa034600.18756428
84Renin-angiotensin system_Homo sapiens_hsa046140.15781842
85Glycerolipid metabolism_Homo sapiens_hsa005610.15201909
86Serotonergic synapse_Homo sapiens_hsa047260.13332606
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.13015200
88Cell cycle_Homo sapiens_hsa041100.12664226
89Ribosome_Homo sapiens_hsa030100.10914008
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10498967
91Ovarian steroidogenesis_Homo sapiens_hsa049130.08767628
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.05900833
93Huntingtons disease_Homo sapiens_hsa050160.04296471
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.03453173
95RNA degradation_Homo sapiens_hsa030180.03203567
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02877315
97Nitrogen metabolism_Homo sapiens_hsa009100.01222263
98p53 signaling pathway_Homo sapiens_hsa041150.01161743
99Glucagon signaling pathway_Homo sapiens_hsa04922-0.0116037
100Oxidative phosphorylation_Homo sapiens_hsa00190-0.0087331

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