TFE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)4.82817380
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.82817380
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.82817380
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.82817380
5modulation by symbiont of host immune response (GO:0052553)4.82817380
6positive regulation by symbiont of host defense response (GO:0052509)4.82817380
7regulation of integrin activation (GO:0033623)4.21704754
8L-alpha-amino acid transmembrane transport (GO:1902475)4.19113858
9positive regulation of SMAD protein import into nucleus (GO:0060391)4.12558494
10regulation of posttranscriptional gene silencing (GO:0060147)3.97803020
11regulation of gene silencing by miRNA (GO:0060964)3.97803020
12regulation of gene silencing by RNA (GO:0060966)3.97803020
13protein localization to endosome (GO:0036010)3.91747468
14negative regulation of erythrocyte differentiation (GO:0045647)3.89398673
15immunoglobulin mediated immune response (GO:0016064)3.76286812
16barbed-end actin filament capping (GO:0051016)3.72783439
17regulation of SMAD protein import into nucleus (GO:0060390)3.62124951
18stress fiber assembly (GO:0043149)3.51980056
19macrophage activation involved in immune response (GO:0002281)3.43364397
20detection of molecule of bacterial origin (GO:0032490)3.41945655
21negative regulation of cell killing (GO:0031342)3.38577809
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.38577809
23apoptotic cell clearance (GO:0043277)3.37706439
24regulation of interferon-beta biosynthetic process (GO:0045357)3.35997394
25heterochromatin organization (GO:0070828)3.30403253
26pre-miRNA processing (GO:0031054)3.26747635
27negative regulation of granulocyte differentiation (GO:0030853)3.26486827
28embryonic process involved in female pregnancy (GO:0060136)3.22866421
29apoptotic process involved in morphogenesis (GO:0060561)3.22496531
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.17515340
31B cell mediated immunity (GO:0019724)3.12678140
32detection of other organism (GO:0098543)3.11995088
33response to peptidoglycan (GO:0032494)3.09215080
34regulation of hippo signaling (GO:0035330)3.08832447
35response to muramyl dipeptide (GO:0032495)3.06350947
36nodal signaling pathway (GO:0038092)3.06304036
37negative regulation of interleukin-12 production (GO:0032695)3.05931604
38mannose metabolic process (GO:0006013)3.04930067
39positive regulation of interferon-alpha production (GO:0032727)3.04454508
40low-density lipoprotein particle clearance (GO:0034383)3.02959945
41regulation of T-helper 2 cell differentiation (GO:0045628)3.02819412
42detection of external biotic stimulus (GO:0098581)3.00674769
43response to laminar fluid shear stress (GO:0034616)2.99311695
44vagina development (GO:0060068)2.97801769
45positive regulation of p38MAPK cascade (GO:1900745)2.95208763
46antigen processing and presentation of endogenous antigen (GO:0019883)2.94217662
47regulation of interferon-alpha production (GO:0032647)2.92754909
48lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92485273
49detection of bacterium (GO:0016045)2.91808445
50skin morphogenesis (GO:0043589)2.91544080
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91201329
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88851572
53modulation by symbiont of host cellular process (GO:0044068)2.86951994
54response to host immune response (GO:0052572)2.86897245
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86897245
56positive regulation of lymphocyte apoptotic process (GO:0070230)2.84986272
57positive regulation of receptor recycling (GO:0001921)2.83612163
58positive regulation of Cdc42 GTPase activity (GO:0043089)2.82529571
59regulation of early endosome to late endosome transport (GO:2000641)2.82511125
60regulation of leukocyte degranulation (GO:0043300)2.82313166
61positive regulation of T cell apoptotic process (GO:0070234)2.81218814
62positive regulation of cellular amide metabolic process (GO:0034250)2.80029132
63regulation of macrophage cytokine production (GO:0010935)2.79552062
64regulation of cholesterol storage (GO:0010885)2.78884573
65regulation of extracellular matrix disassembly (GO:0010715)2.75557301
66embryonic placenta development (GO:0001892)2.75464804
67microglial cell activation (GO:0001774)2.75440735
68response to host (GO:0075136)2.72684920
69response to host defenses (GO:0052200)2.72684920
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72684920
71hyaluronan catabolic process (GO:0030214)2.72676772
72histone H4-K12 acetylation (GO:0043983)2.72550288
73regulation of mononuclear cell migration (GO:0071675)2.72243207
74positive regulation of interferon-beta production (GO:0032728)2.71810352
75regulation of mast cell degranulation (GO:0043304)2.67495280
76cortical actin cytoskeleton organization (GO:0030866)2.66647010
77positive regulation of gamma-delta T cell activation (GO:0046645)2.66611313
78regulation of myeloid leukocyte mediated immunity (GO:0002886)2.65041476
79detection of biotic stimulus (GO:0009595)2.64551730
80pinocytosis (GO:0006907)2.64117355
81determination of adult lifespan (GO:0008340)2.63501205
82trophectodermal cell differentiation (GO:0001829)2.62927940
83negative regulation of histone methylation (GO:0031061)2.62653625
84folic acid-containing compound biosynthetic process (GO:0009396)2.61988570
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61029126
86regulation of translational fidelity (GO:0006450)2.59662398
87negative regulation of toll-like receptor signaling pathway (GO:0034122)2.59304548
88positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58203304
89positive regulation of chemokine biosynthetic process (GO:0045080)2.58035248
90adherens junction assembly (GO:0034333)2.57527655
91basic amino acid transport (GO:0015802)2.56315996
92positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55820095
93response to UV-C (GO:0010225)2.55408664
94regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54916223
95focal adhesion assembly (GO:0048041)2.53956384
96cell-substrate adherens junction assembly (GO:0007045)2.53956384
97paraxial mesoderm development (GO:0048339)2.52361469
98NIK/NF-kappaB signaling (GO:0038061)2.51206262
99I-kappaB phosphorylation (GO:0007252)2.51196444
100female genitalia development (GO:0030540)2.50933407
101nuclear pore organization (GO:0006999)2.50203598
102cell-substrate junction assembly (GO:0007044)2.49342002
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49331310
104positive regulation of macrophage cytokine production (GO:0060907)2.49022926
105germinal center formation (GO:0002467)2.48615739
106cellular extravasation (GO:0045123)2.48487586
107cellular response to virus (GO:0098586)2.46572033
108nuclear pore complex assembly (GO:0051292)2.44150178
109positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43743146
110neutrophil activation involved in immune response (GO:0002283)2.42818506
111intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.42504977
112mitotic nuclear envelope disassembly (GO:0007077)2.42428606
113Golgi transport vesicle coating (GO:0048200)2.41838316
114COPI coating of Golgi vesicle (GO:0048205)2.41838316
115NLS-bearing protein import into nucleus (GO:0006607)2.41812513
116negative regulation of gene silencing (GO:0060969)2.41617546
117positive regulation of protein dephosphorylation (GO:0035307)2.41051680
118regulation of gene silencing (GO:0060968)2.39850267
119positive regulation of leukocyte apoptotic process (GO:2000108)2.37978872
120positive regulation of extracellular matrix organization (GO:1903055)2.37210767
121basement membrane organization (GO:0071711)2.34949935
122protein localization to kinetochore (GO:0034501)2.34675894
123positive regulation of leukocyte degranulation (GO:0043302)2.34651113
124cortical cytoskeleton organization (GO:0030865)2.34636277
125interferon-gamma secretion (GO:0072643)2.34329284
126positive regulation of protein homooligomerization (GO:0032464)2.34001389
127macrophage activation (GO:0042116)2.33718022
128regulation of regulated secretory pathway (GO:1903305)2.33471555
129hypotonic response (GO:0006971)2.33229352
130positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.32772460
131leukocyte aggregation (GO:0070486)2.32058225
132mRNA stabilization (GO:0048255)2.31790484
133RNA stabilization (GO:0043489)2.31790484
134regulation of mast cell activation involved in immune response (GO:0033006)2.31266435
135wound healing, spreading of epidermal cells (GO:0035313)2.30688953
136negative regulation of interleukin-6 production (GO:0032715)2.30488195
137positive regulation of protein oligomerization (GO:0032461)2.30368520
138negative regulation of interleukin-8 production (GO:0032717)2.30230050
139nuclear envelope disassembly (GO:0051081)2.28768941
140membrane disassembly (GO:0030397)2.28768941
141regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27079490
142positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.26721071
143negative regulation of type 2 immune response (GO:0002829)2.26422550
144negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.25908702
145pore complex assembly (GO:0046931)2.25861595
146positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25467101
147negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.25293524
148pentose-phosphate shunt (GO:0006098)2.25215449
149intracellular estrogen receptor signaling pathway (GO:0030520)2.24727572
150regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.24143989
151establishment of apical/basal cell polarity (GO:0035089)2.23606031
152intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)2.23363281
153regulation of interleukin-8 biosynthetic process (GO:0045414)2.23185299
154apoptotic process involved in development (GO:1902742)2.22901851
155regulation of type 2 immune response (GO:0002828)2.21610096
156regulation of dendritic cell antigen processing and presentation (GO:0002604)2.21534601
157developmental programmed cell death (GO:0010623)2.20913125
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.20674659
159antigen processing and presentation via MHC class Ib (GO:0002475)2.18677735
160positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.17171074
161signal complex assembly (GO:0007172)2.16619252
162regulation of type I interferon-mediated signaling pathway (GO:0060338)2.15548766
163granulocyte activation (GO:0036230)2.15155586
164vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.15051649
165negative regulation of cytokine production involved in immune response (GO:0002719)2.14906399
166negative regulation of homotypic cell-cell adhesion (GO:0034111)2.14812305
167cellular response to type I interferon (GO:0071357)2.14464335
168type I interferon signaling pathway (GO:0060337)2.14464335
169positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.13835326
170positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.13578270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.20226624
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.91174107
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25175308
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.92343226
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.91924794
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.88404210
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.88404210
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.88404210
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42499893
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.41144865
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.25397819
12MYC_22102868_ChIP-Seq_BL_Human2.25330675
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.23700281
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.08299916
15ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.05712636
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05045683
17VDR_21846776_ChIP-Seq_THP-1_Human1.89565281
18STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84607644
19KDM2B_26808549_Chip-Seq_K562_Human1.82361367
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82215663
21TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74504704
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.73669383
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73570026
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73163425
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.72506860
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.71638705
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65473916
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.65009433
29TCF7_22412390_ChIP-Seq_EML_Mouse1.63038663
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61354289
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60090130
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59186634
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55241670
34* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52984854
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51830617
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51407393
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51128114
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.49859837
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.47209448
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45589124
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45578738
42TFEB_21752829_ChIP-Seq_HELA_Human1.44144358
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43937233
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43652732
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43380324
46* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42357918
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42115004
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40728323
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40604983
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40556774
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38771155
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38466043
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38071901
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37534053
55SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37267484
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36845445
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36671230
58TCF3_18692474_ChIP-Seq_MESCs_Mouse1.36563398
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36553989
60KDM2B_26808549_Chip-Seq_DND41_Human1.36151465
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34579841
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29734664
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28755280
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27987693
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27436169
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27147144
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26359292
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.26091544
69ATF3_27146783_Chip-Seq_COLON_Human1.25826384
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.25273434
71RACK7_27058665_Chip-Seq_MCF-7_Human1.24181656
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.23430203
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.22900873
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21241384
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21053973
76MAF_26560356_Chip-Seq_TH1_Human1.21016098
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20586533
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19169710
79MAF_26560356_Chip-Seq_TH2_Human1.18902995
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.16846884
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16792395
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16188236
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15439104
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15366654
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15241762
86NCOR1_26117541_ChIP-Seq_K562_Human1.14738279
87POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14378597
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13739328
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13330278
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13198654
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13098333
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13047140
93SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12962772
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.12944235
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12796843
96SPI1_23547873_ChIP-Seq_NB4_Human1.12341800
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11738830
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11258788
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10978940
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10964955
101GATA1_19941826_ChIP-Seq_K562_Human1.09917641
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.09310639
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08971041
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.08903132
105* P68_20966046_ChIP-Seq_HELA_Human1.08682008
106LXR_22292898_ChIP-Seq_THP-1_Human1.08589524
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08515426
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07775361
109SMC4_20622854_ChIP-Seq_HELA_Human1.06889731
110SPI1_23127762_ChIP-Seq_K562_Human1.06883687
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06525319
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06422856
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06340709
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06060385
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06058539
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05612164
117VDR_24763502_ChIP-Seq_THP-1_Human1.05101019
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04701805
119CLOCK_20551151_ChIP-Seq_293T_Human1.04136487
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03474053
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02597365
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02549588
123P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01904087
124CREB1_26743006_Chip-Seq_LNCaP_Human1.01258135
125NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00945429
126OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00142556
127ZNF263_19887448_ChIP-Seq_K562_Human1.00130811
128RXR_22158963_ChIP-Seq_LIVER_Mouse0.99898001
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.99163392
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98555261
131UTX_26944678_Chip-Seq_JUKART_Human0.98183071
132SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96701559
133TP63_19390658_ChIP-ChIP_HaCaT_Human0.96514815
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96328504
135PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96117665
136TP53_22127205_ChIP-Seq_IMR90_Human0.93916248
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.93464935
138NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92887649
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92051331
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91926687
141NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91548717
142SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91301454
143NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91108424
144KAP1_27257070_Chip-Seq_ESCs_Mouse0.90670049
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90488009
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.90259852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.03516460
2MP0010352_gastrointestinal_tract_polyps2.87928982
3MP0009278_abnormal_bone_marrow2.77986809
4MP0005076_abnormal_cell_differentiation2.75220187
5MP0009840_abnormal_foam_cell2.73227529
6MP0005058_abnormal_lysosome_morphology2.57006925
7MP0003724_increased_susceptibility_to2.56775179
8MP0003566_abnormal_cell_adhesion2.51765573
9MP0003436_decreased_susceptibility_to2.48907393
10MP0003303_peritoneal_inflammation2.31781525
11MP0001958_emphysema2.25143552
12MP0008260_abnormal_autophagy2.22831116
13MP0002254_reproductive_system_inflammat2.14933654
14MP0003300_gastrointestinal_ulcer2.14393549
15MP0005451_abnormal_body_composition2.06595314
16MP0010307_abnormal_tumor_latency2.03329775
17MP0001835_abnormal_antigen_presentation1.99745359
18MP0003172_abnormal_lysosome_physiology1.91383358
19MP0005023_abnormal_wound_healing1.85553232
20MP0003453_abnormal_keratinocyte_physiol1.76288199
21MP0006082_CNS_inflammation1.71293473
22MP0001545_abnormal_hematopoietic_system1.68482865
23MP0005397_hematopoietic_system_phenotyp1.68482865
24MP0003111_abnormal_nucleus_morphology1.67777001
25MP0005257_abnormal_intraocular_pressure1.66001611
26MP0003448_altered_tumor_morphology1.63363225
27MP0008007_abnormal_cellular_replicative1.55682152
28MP0003191_abnormal_cellular_cholesterol1.52285164
29MP0000858_altered_metastatic_potential1.50722734
30MP0003329_amyloid_beta_deposits1.50625825
31MP0002877_abnormal_melanocyte_morpholog1.50582695
32MP0004947_skin_inflammation1.49426712
33MP0002419_abnormal_innate_immunity1.46940274
34MP0003077_abnormal_cell_cycle1.44288653
35MP0005275_abnormal_skin_tensile1.43522739
36MP0000604_amyloidosis1.42359962
37MP0004957_abnormal_blastocyst_morpholog1.41319998
38MP0008057_abnormal_DNA_replication1.41137804
39MP0009785_altered_susceptibility_to1.39521908
40MP0002405_respiratory_system_inflammati1.38014806
41MP0004264_abnormal_extraembryonic_tissu1.37163497
42MP0004272_abnormal_basement_membrane1.35556788
43MP0001790_abnormal_immune_system1.35128403
44MP0005387_immune_system_phenotype1.35128403
45MP0004510_myositis1.34339803
46MP0003690_abnormal_glial_cell1.32372251
47MP0001542_abnormal_bone_strength1.31417333
48MP0000685_abnormal_immune_system1.30734427
49MP0002452_abnormal_antigen_presenting1.29979398
50MP0003693_abnormal_embryo_hatching1.29649324
51MP0003890_abnormal_embryonic-extraembry1.27089662
52MP0001849_ear_inflammation1.26980068
53MP0000343_altered_response_to1.25803830
54MP0002086_abnormal_extraembryonic_tissu1.24526976
55MP0005000_abnormal_immune_tolerance1.24118849
56MP0000350_abnormal_cell_proliferation1.23726292
57MP0002653_abnormal_ependyma_morphology1.23559877
58MP0001533_abnormal_skeleton_physiology1.22919852
59MP0004185_abnormal_adipocyte_glucose1.20382660
60MP0001800_abnormal_humoral_immune1.19139353
61MP0005164_abnormal_response_to1.16682555
62MP0005464_abnormal_platelet_physiology1.14809298
63MP0001672_abnormal_embryogenesis/_devel1.13178579
64MP0005380_embryogenesis_phenotype1.13178579
65MP0009333_abnormal_splenocyte_physiolog1.12718170
66MP0002060_abnormal_skin_morphology1.12621326
67MP0008004_abnormal_stomach_pH1.12235570
68MP0001915_intracranial_hemorrhage1.11951011
69MP0008438_abnormal_cutaneous_collagen1.09746923
70MP0005025_abnormal_response_to1.07584700
71MP0003279_aneurysm1.06789129
72MP0002088_abnormal_embryonic_growth/wei1.06163116
73MP0003091_abnormal_cell_migration1.05979526
74MP0003984_embryonic_growth_retardation1.05585656
75MP0003075_altered_response_to1.05262022
76MP0002723_abnormal_immune_serum1.04707777
77MP0005409_darkened_coat_color1.03905578
78MP0005666_abnormal_adipose_tissue1.03789742
79MP0010030_abnormal_orbit_morphology1.03729350
80MP0001730_embryonic_growth_arrest1.03223408
81MP0005166_decreased_susceptibility_to1.01630248
82MP0000569_abnormal_digit_pigmentation0.99930924
83MP0003828_pulmonary_edema0.99593468
84MP0001697_abnormal_embryo_size0.98930374
85MP0002085_abnormal_embryonic_tissue0.98702882
86MP0002148_abnormal_hypersensitivity_rea0.98373423
87MP0004197_abnormal_fetal_growth/weight/0.98294415
88MP0002796_impaired_skin_barrier0.96829421
89MP0005623_abnormal_meninges_morphology0.96626632
90MP0010094_abnormal_chromosome_stability0.95826698
91MP0005375_adipose_tissue_phenotype0.95492685
92MP0002084_abnormal_developmental_patter0.94978137
93MP0001819_abnormal_immune_cell0.94686781
94MP0000767_abnormal_smooth_muscle0.93513291
95MP0003045_fibrosis0.92665393
96MP0005503_abnormal_tendon_morphology0.92624310
97MP0002420_abnormal_adaptive_immunity0.92431005
98MP0000490_abnormal_crypts_of0.92389636
99MP0005390_skeleton_phenotype0.91617430
100MP0000689_abnormal_spleen_morphology0.91072860
101MP0005310_abnormal_salivary_gland0.89591664
102MP0000371_diluted_coat_color0.89046551
103MP0003795_abnormal_bone_structure0.88896039
104MP0001845_abnormal_inflammatory_respons0.88706768
105MP0001348_abnormal_lacrimal_gland0.87854128
106MP0002896_abnormal_bone_mineralization0.87532743
107MP0002933_joint_inflammation0.87319988
108MP0004883_abnormal_blood_vessel0.87225630
109MP0005621_abnormal_cell_physiology0.86213520
110MP0008469_abnormal_protein_level0.85920021
111MP0001853_heart_inflammation0.85782779
112MP0002019_abnormal_tumor_incidence0.85751761
113MP0000751_myopathy0.85245997
114MP0002138_abnormal_hepatobiliary_system0.83788310
115MP0010155_abnormal_intestine_physiology0.83696413
116MP0002722_abnormal_immune_system0.83646978
117MP0006054_spinal_hemorrhage0.83145763
118MP0009764_decreased_sensitivity_to0.82456934
119MP0002295_abnormal_pulmonary_circulatio0.82352583
120MP0002396_abnormal_hematopoietic_system0.82260711
121MP0000920_abnormal_myelination0.82244450
122MP0002398_abnormal_bone_marrow0.82019877
123MP0004233_abnormal_muscle_weight0.81862195
124MP0005595_abnormal_vascular_smooth0.81329066
125MP0000313_abnormal_cell_death0.81197243
126MP0002080_prenatal_lethality0.81040977
127MP0002998_abnormal_bone_remodeling0.80793328
128MP0005508_abnormal_skeleton_morphology0.79086672
129MP0008874_decreased_physiological_sensi0.78787240
130MP0004858_abnormal_nervous_system0.78738835
131MP0005165_increased_susceptibility_to0.78675397
132MP0004133_heterotaxia0.78415980
133MP0000249_abnormal_blood_vessel0.78407001
134MP0003183_abnormal_peptide_metabolism0.78096491
135MP0000750_abnormal_muscle_regeneration0.77037144
136MP0000678_abnormal_parathyroid_gland0.76448064
137MP0002925_abnormal_cardiovascular_devel0.76344714
138MP0000716_abnormal_immune_system0.75900938
139MP0000733_abnormal_muscle_development0.72940682
140MP0002429_abnormal_blood_cell0.72417995
141MP0001851_eye_inflammation0.71210970

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.15156669
2Eczematoid dermatitis (HP:0000976)3.78205307
3Recurrent abscess formation (HP:0002722)3.50292049
4Agnosia (HP:0010524)3.28507427
5Recurrent bacterial skin infections (HP:0005406)3.09574530
6Cerebral aneurysm (HP:0004944)2.99439522
7Recurrent gram-negative bacterial infections (HP:0005420)2.98437367
8Increased connective tissue (HP:0009025)2.70131316
9Myocardial infarction (HP:0001658)2.69994558
10Glomerulonephritis (HP:0000099)2.69147395
11Hand muscle atrophy (HP:0009130)2.63817487
12Abnormality of glycosphingolipid metabolism (HP:0004343)2.59801938
13Abnormality of glycolipid metabolism (HP:0010969)2.59801938
14Abnormality of liposaccharide metabolism (HP:0010968)2.59801938
15Increased variability in muscle fiber diameter (HP:0003557)2.58676661
16Dilatation of the ascending aorta (HP:0005111)2.58020643
17Increased cerebral lipofuscin (HP:0011813)2.57084533
18Urinary glycosaminoglycan excretion (HP:0003541)2.55528887
19Mucopolysacchariduria (HP:0008155)2.55528887
20Ependymoma (HP:0002888)2.55309586
21Aortic aneurysm (HP:0004942)2.54838458
22Urethral obstruction (HP:0000796)2.54419795
23Obstructive sleep apnea (HP:0002870)2.52499710
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52479423
25Abnormality of polysaccharide metabolism (HP:0011012)2.52479423
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52479423
27Abnormality of macrophages (HP:0004311)2.49212344
28Vascular tortuosity (HP:0004948)2.48462716
29Ankle contracture (HP:0006466)2.46998337
30Dysostosis multiplex (HP:0000943)2.46425053
31Amyloidosis (HP:0011034)2.40272568
32Abnormality of complement system (HP:0005339)2.39794353
33Neurofibrillary tangles (HP:0002185)2.37522197
34Pustule (HP:0200039)2.36503337
35Vacuolated lymphocytes (HP:0001922)2.35040871
36Arterial tortuosity (HP:0005116)2.34445671
37Peritonitis (HP:0002586)2.33724833
38Spinal rigidity (HP:0003306)2.33700591
39Rib fusion (HP:0000902)2.32233194
40Mediastinal lymphadenopathy (HP:0100721)2.31773328
41Abnormality of skeletal muscle fiber size (HP:0012084)2.31709241
42Distal lower limb amyotrophy (HP:0008944)2.31246971
43Upper limb amyotrophy (HP:0009129)2.29390451
44Distal upper limb amyotrophy (HP:0007149)2.29390451
45Spinal muscular atrophy (HP:0007269)2.28622166
46Fragile skin (HP:0001030)2.24334079
47Upper motor neuron abnormality (HP:0002127)2.24014537
48Genu recurvatum (HP:0002816)2.23662223
49Aortic dissection (HP:0002647)2.23616274
50Axonal loss (HP:0003447)2.19095629
51Disinhibition (HP:0000734)2.18692731
52Autoimmune thrombocytopenia (HP:0001973)2.17961815
53Aneurysm (HP:0002617)2.16839140
54Hyperacusis (HP:0010780)2.16370023
55Complement deficiency (HP:0004431)2.15821261
56Supranuclear gaze palsy (HP:0000605)2.15255818
57Mitral regurgitation (HP:0001653)2.14991376
58Wormian bones (HP:0002645)2.14784455
59Cerebral inclusion bodies (HP:0100314)2.14562756
60Gingivitis (HP:0000230)2.14107183
61Intestinal fistula (HP:0100819)2.14079490
62Atrophic scars (HP:0001075)2.13014637
63Segmental peripheral demyelination/remyelination (HP:0003481)2.09963225
64Nuclear cataract (HP:0100018)2.08457798
65Achilles tendon contracture (HP:0001771)2.07950626
66Prostate neoplasm (HP:0100787)2.06002977
67Disproportionate tall stature (HP:0001519)2.05058733
68Short humerus (HP:0005792)2.04418873
69Spontaneous hematomas (HP:0007420)2.04100874
70Thin bony cortex (HP:0002753)2.04094436
71Broad face (HP:0000283)2.03256411
72Increased IgE level (HP:0003212)2.01703876
73Slender build (HP:0001533)2.01566598
74Abnormality of the astrocytes (HP:0100707)2.01202994
75Astrocytoma (HP:0009592)2.01202994
76Ulnar bowing (HP:0003031)2.01135363
77Orchitis (HP:0100796)2.00588443
78Pathologic fracture (HP:0002756)1.99915951
79Broad metatarsal (HP:0001783)1.99743183
80Polycythemia (HP:0001901)1.98885365
81Increased neuronal autofluorescent lipopigment (HP:0002074)1.97519286
82Cervical subluxation (HP:0003308)1.97173997
83Interstitial pulmonary disease (HP:0006530)1.96866853
84Bladder diverticulum (HP:0000015)1.95488691
85Vertebral compression fractures (HP:0002953)1.95032641
86Aplasia/hypoplasia of the humerus (HP:0006507)1.94652529
87Vaginal fistula (HP:0004320)1.94534764
88Nephritis (HP:0000123)1.94476859
89Selective tooth agenesis (HP:0001592)1.90409978
90Rectovaginal fistula (HP:0000143)1.90267137
91Rectal fistula (HP:0100590)1.90267137
92Abnormality of the distal phalanges of the toes (HP:0010182)1.89484819
93Protrusio acetabuli (HP:0003179)1.88802458
94Fused cervical vertebrae (HP:0002949)1.88612882
95Shallow orbits (HP:0000586)1.88327140
96Osteolytic defects of the hand bones (HP:0009699)1.86289727
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.86289727
98Emphysema (HP:0002097)1.84789425
99Elevated erythrocyte sedimentation rate (HP:0003565)1.83973411
100Polygenic inheritance (HP:0010982)1.83290150
101Abnormality of the Achilles tendon (HP:0005109)1.82918752
102Hematochezia (HP:0002573)1.82501826
103Biconcave vertebral bodies (HP:0004586)1.81504430
104Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.80031111
105Vertebral hypoplasia (HP:0008417)1.80031111
106Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79177388
107Malignant gastrointestinal tract tumors (HP:0006749)1.78535194
108Gastrointestinal carcinoma (HP:0002672)1.78535194
109Retrobulbar optic neuritis (HP:0100654)1.77681690
110Optic neuritis (HP:0100653)1.77681690
111Spinal cord lesions (HP:0100561)1.77637168
112Syringomyelia (HP:0003396)1.77637168
113Lower limb amyotrophy (HP:0007210)1.76220696
114Personality changes (HP:0000751)1.75439647
115Hypertriglyceridemia (HP:0002155)1.75336923
116Obstructive lung disease (HP:0006536)1.75169134
117Chronic obstructive pulmonary disease (HP:0006510)1.75169134
118Difficulty climbing stairs (HP:0003551)1.74785162
119Vertebral fusion (HP:0002948)1.73536070
120Myositis (HP:0100614)1.73248264
121Metaphyseal cupping (HP:0003021)1.73238664
122Joint stiffness (HP:0001387)1.73082136
123Gastrointestinal infarctions (HP:0005244)1.71462239
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.70705012
125Abnormality of the peritoneum (HP:0002585)1.69952994
126Long palpebral fissure (HP:0000637)1.69353097
127Urticaria (HP:0001025)1.69347159
128Recurrent fungal infections (HP:0002841)1.68949343
129Asymmetric septal hypertrophy (HP:0001670)1.68850553
130Joint laxity (HP:0001388)1.68716658
131Type 1 muscle fiber predominance (HP:0003803)1.68129325
132Neuronal loss in central nervous system (HP:0002529)1.67950278
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67877991
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.67732869
135Turricephaly (HP:0000262)1.67227061
136Hemorrhage of the eye (HP:0011885)1.66930862
137Purpura (HP:0000979)1.66568765
138Neoplasm of the oral cavity (HP:0100649)1.65067007
139Tetraparesis (HP:0002273)1.61528968
140Mitral valve prolapse (HP:0001634)1.60052672
141Peripheral demyelination (HP:0011096)1.59094729
142Chromsome breakage (HP:0040012)1.57283579
143Spondylolisthesis (HP:0003302)1.55395949
144Increased CSF protein (HP:0002922)1.54836604
145Premature rupture of membranes (HP:0001788)1.54441485
146Loss of speech (HP:0002371)1.53181119
147Cellulitis (HP:0100658)1.52777718
148Esophageal varix (HP:0002040)1.52137492
149Orthostatic hypotension (HP:0001278)1.51765008
150Leiomyosarcoma (HP:0100243)1.51042530
151Uterine leiomyosarcoma (HP:0002891)1.51042530
152Recurrent skin infections (HP:0001581)1.49879810
153Large earlobe (HP:0009748)1.47907561
154Increased density of long bones (HP:0006392)1.47611901
155Bone pain (HP:0002653)1.46656657
156Premature ovarian failure (HP:0008209)1.43746629
157Distal lower limb muscle weakness (HP:0009053)1.43182030
158Blue sclerae (HP:0000592)1.42459824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.87254808
2ERN13.63780046
3PRPF4B3.28779375
4EPHA22.50122057
5STK102.46923247
6MAP3K102.41977573
7TGFBR22.33097842
8TRIB32.28532309
9SMG12.11823961
10ICK1.83856981
11TYK21.74203615
12IRAK31.71163146
13BMX1.63220105
14PAK41.61282521
15MAP3K131.60498781
16LATS21.58252208
17TBK11.48096401
18MAP3K141.45095930
19IKBKB1.43018856
20TESK11.41579803
21CHUK1.39379182
22CDC42BPA1.38424951
23CDK71.36913868
24LATS11.33570600
25TTK1.33004433
26CSK1.32884749
27RPS6KA41.32788586
28PTK61.32057953
29PKN21.30624399
30CDK61.29176673
31FGFR41.28084347
32RIPK11.26417006
33BLK1.25583897
34MAP3K11.25297844
35MARK21.23302141
36PIM11.22139669
37ARAF1.21608664
38DDR21.20255128
39NEK21.19081395
40CAMK1D1.18638186
41MTOR1.18267247
42MATK1.16741550
43STK31.14057813
44TAOK11.10780190
45MAP3K81.10575870
46MAPK151.10465715
47MAP3K111.08009254
48EPHB11.07359062
49PIM21.07133027
50CDK41.05201704
51SIK31.04502818
52PTK21.03462093
53EEF2K1.03088398
54DMPK1.03029589
55IRAK20.98678155
56MAP2K30.95559109
57TTN0.95022193
58MAP3K30.94321240
59PDPK10.94109109
60TAOK20.93860568
61ALK0.93248423
62FGR0.92626484
63RPS6KA20.90671133
64MOS0.88192050
65NME20.88069816
66CSF1R0.87470752
67PDGFRA0.84875927
68NTRK10.83888702
69STK380.83661608
70TNK20.83626196
71MAP3K90.80310891
72MAP3K60.80067103
73PRKG20.78200918
74JAK20.77828053
75FES0.75348605
76TYRO30.74453860
77JAK30.71496433
78STK40.71106981
79BRD40.70894252
80SCYL20.70518843
81PDGFRB0.69058004
82MYLK0.68464593
83FLT30.67723894
84PLK10.66757437
85PRKD30.66197542
86KSR20.65691931
87LRRK20.65384950
88HCK0.65159281
89DYRK1B0.64399820
90JAK10.62912564
91RPS6KC10.62510913
92RPS6KL10.62510913
93GRK60.61354572
94ZAP700.61221120
95SIK20.60728814
96MAP4K10.59477082
97BUB10.59403871
98MAP2K20.59281755
99MET0.59224501
100PDK10.59107053
101MAPK70.58835252
102CDC70.58167256
103PAK20.57623012
104CHEK20.57290823
105SIK10.56202707
106MAPK120.55524490
107GSK3A0.54057628
108PAK60.53677555
109MARK30.53476895
110IRAK40.53281785
111TAOK30.52919371
112EGFR0.52421121
113BRAF0.52228717
114MAPKAPK20.52197646
115HIPK20.51425495
116MAPKAPK30.51077852
117RET0.50905649
118ABL20.50318108
119TESK20.50279928
120CAMK1G0.49736618
121ROCK20.49675153
122LIMK10.49170393
123MAPK10.47719207
124SGK30.47266291
125RPS6KA10.46950404
126EPHB20.46543147
127LMTK20.46376884
128MAP3K50.45653473
129CHEK10.45059180
130MAP3K70.44728479
131RIPK40.44593851
132PAK10.44391130
133ERBB40.44189535
134PRKD20.43725295
135IKBKE0.43682398
136ATR0.43571149
137CDK20.42971098
138RAF10.42811751
139BTK0.40612161
140IRAK10.40268729
141RPS6KA60.39304647

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.74625145
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.54765657
3Leishmaniasis_Homo sapiens_hsa051402.36911643
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32867888
5Lysosome_Homo sapiens_hsa041421.86658100
6Osteoclast differentiation_Homo sapiens_hsa043801.86565388
7Legionellosis_Homo sapiens_hsa051341.75582714
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.66307289
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60003155
10Apoptosis_Homo sapiens_hsa042101.58971102
11Chronic myeloid leukemia_Homo sapiens_hsa052201.54579304
12Notch signaling pathway_Homo sapiens_hsa043301.54375365
13Adherens junction_Homo sapiens_hsa045201.54370002
14Other glycan degradation_Homo sapiens_hsa005111.53211534
15Tuberculosis_Homo sapiens_hsa051521.41985031
16TNF signaling pathway_Homo sapiens_hsa046681.41190045
17p53 signaling pathway_Homo sapiens_hsa041151.39768297
18Pertussis_Homo sapiens_hsa051331.38081024
19Toxoplasmosis_Homo sapiens_hsa051451.37825933
20Shigellosis_Homo sapiens_hsa051311.37076883
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35982146
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35510030
23One carbon pool by folate_Homo sapiens_hsa006701.34008999
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32488396
25Small cell lung cancer_Homo sapiens_hsa052221.28796872
26Antigen processing and presentation_Homo sapiens_hsa046121.27866168
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27585072
28MicroRNAs in cancer_Homo sapiens_hsa052061.27083279
29B cell receptor signaling pathway_Homo sapiens_hsa046621.25809673
30Herpes simplex infection_Homo sapiens_hsa051681.24341767
31Acute myeloid leukemia_Homo sapiens_hsa052211.24335809
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24271621
33Malaria_Homo sapiens_hsa051441.19069153
34Influenza A_Homo sapiens_hsa051641.17069422
35Bladder cancer_Homo sapiens_hsa052191.16958677
36Prion diseases_Homo sapiens_hsa050201.14534986
37Mismatch repair_Homo sapiens_hsa034301.13878660
38Measles_Homo sapiens_hsa051621.13281057
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11434558
40RNA transport_Homo sapiens_hsa030131.11417544
41mTOR signaling pathway_Homo sapiens_hsa041501.10718353
42Pancreatic cancer_Homo sapiens_hsa052121.07858792
43Hepatitis B_Homo sapiens_hsa051611.07443213
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.07007262
45Endocytosis_Homo sapiens_hsa041441.05280735
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04156886
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03340535
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02845220
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02552572
50Cell cycle_Homo sapiens_hsa041101.02152805
51Amoebiasis_Homo sapiens_hsa051461.01773231
52Viral carcinogenesis_Homo sapiens_hsa052030.99169539
53Proteoglycans in cancer_Homo sapiens_hsa052050.98981801
54GnRH signaling pathway_Homo sapiens_hsa049120.98692979
55TGF-beta signaling pathway_Homo sapiens_hsa043500.98391594
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98116868
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97873621
58Salmonella infection_Homo sapiens_hsa051320.96834070
59Complement and coagulation cascades_Homo sapiens_hsa046100.95429110
60HTLV-I infection_Homo sapiens_hsa051660.92751223
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.92574349
62DNA replication_Homo sapiens_hsa030300.91609029
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.90656333
64Glioma_Homo sapiens_hsa052140.90558401
65Phagosome_Homo sapiens_hsa041450.90543487
66Lysine degradation_Homo sapiens_hsa003100.88469151
67Epstein-Barr virus infection_Homo sapiens_hsa051690.88451568
68Hippo signaling pathway_Homo sapiens_hsa043900.86434916
69Base excision repair_Homo sapiens_hsa034100.86277392
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86062604
71Estrogen signaling pathway_Homo sapiens_hsa049150.85151408
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84366057
73ErbB signaling pathway_Homo sapiens_hsa040120.84011608
74ECM-receptor interaction_Homo sapiens_hsa045120.83953837
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82560524
76Platelet activation_Homo sapiens_hsa046110.82196077
77Colorectal cancer_Homo sapiens_hsa052100.81895977
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.81748510
79Thyroid cancer_Homo sapiens_hsa052160.80719564
80Insulin signaling pathway_Homo sapiens_hsa049100.80336865
81* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79567524
82African trypanosomiasis_Homo sapiens_hsa051430.79226071
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78576116
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77253603
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.76234222
86Galactose metabolism_Homo sapiens_hsa000520.75877433
87Vibrio cholerae infection_Homo sapiens_hsa051100.75114003
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73213005
89Rap1 signaling pathway_Homo sapiens_hsa040150.72857624
90T cell receptor signaling pathway_Homo sapiens_hsa046600.72708681
91VEGF signaling pathway_Homo sapiens_hsa043700.71918218
92Viral myocarditis_Homo sapiens_hsa054160.70264333
93Dorso-ventral axis formation_Homo sapiens_hsa043200.70248998
94Choline metabolism in cancer_Homo sapiens_hsa052310.69853643
95Focal adhesion_Homo sapiens_hsa045100.67305230
96Pentose phosphate pathway_Homo sapiens_hsa000300.67222583
97Chemokine signaling pathway_Homo sapiens_hsa040620.67021832
98Graft-versus-host disease_Homo sapiens_hsa053320.66374280
99Prostate cancer_Homo sapiens_hsa052150.65987275
100Hematopoietic cell lineage_Homo sapiens_hsa046400.65317496
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64282360
102MAPK signaling pathway_Homo sapiens_hsa040100.63265348
103Endometrial cancer_Homo sapiens_hsa052130.63041494
104Prolactin signaling pathway_Homo sapiens_hsa049170.62511882
105Rheumatoid arthritis_Homo sapiens_hsa053230.62220348
106Hepatitis C_Homo sapiens_hsa051600.62052993
107HIF-1 signaling pathway_Homo sapiens_hsa040660.61237282
108Long-term potentiation_Homo sapiens_hsa047200.61163162
109mRNA surveillance pathway_Homo sapiens_hsa030150.60643041
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60617689
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60475625
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59383863
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59297497
114Nitrogen metabolism_Homo sapiens_hsa009100.58115574
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.57712601
116Pathways in cancer_Homo sapiens_hsa052000.57702240
117Spliceosome_Homo sapiens_hsa030400.57566170
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56493801
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56439429
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56349385
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56051786
122FoxO signaling pathway_Homo sapiens_hsa040680.55039131
123Renal cell carcinoma_Homo sapiens_hsa052110.54698256
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.54256451
125Inositol phosphate metabolism_Homo sapiens_hsa005620.54123722
126Non-small cell lung cancer_Homo sapiens_hsa052230.52890301
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.51251031
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51165545
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50755212
130Insulin resistance_Homo sapiens_hsa049310.49996312
131Fatty acid biosynthesis_Homo sapiens_hsa000610.49543796
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48828327
133Asthma_Homo sapiens_hsa053100.48505207

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