TFEB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.69591739
2negative regulation of cell killing (GO:0031342)5.69591739
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.41446555
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.27650361
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.90841036
6macrophage activation involved in immune response (GO:0002281)4.81151839
7detection of other organism (GO:0098543)4.78151512
8detection of bacterium (GO:0016045)4.73723032
9neutrophil activation involved in immune response (GO:0002283)4.55194420
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.54355857
11response to peptidoglycan (GO:0032494)4.46026235
12creatine metabolic process (GO:0006600)4.45085219
13detection of external biotic stimulus (GO:0098581)4.06880747
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.03879730
15transcription from mitochondrial promoter (GO:0006390)3.98198742
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.92774070
17negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.86791474
18cytidine deamination (GO:0009972)3.83988069
19cytidine metabolic process (GO:0046087)3.83988069
20cytidine catabolic process (GO:0006216)3.83988069
21germinal center formation (GO:0002467)3.80494511
22interferon-gamma-mediated signaling pathway (GO:0060333)3.80473108
23cellular response to type I interferon (GO:0071357)3.79321635
24type I interferon signaling pathway (GO:0060337)3.79321635
25muscle filament sliding (GO:0030049)3.77915766
26actin-myosin filament sliding (GO:0033275)3.77915766
27response to type I interferon (GO:0034340)3.77790762
28detection of molecule of bacterial origin (GO:0032490)3.76836219
29apoptotic process involved in morphogenesis (GO:0060561)3.73807271
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.73406486
31response to host immune response (GO:0052572)3.73406486
32cellular extravasation (GO:0045123)3.70458282
33labyrinthine layer development (GO:0060711)3.69824904
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.68297285
35sarcomere organization (GO:0045214)3.65095901
36cellular response to zinc ion (GO:0071294)3.64911518
37leukocyte aggregation (GO:0070486)3.64694338
38defense response to protozoan (GO:0042832)3.62551913
39respiratory burst (GO:0045730)3.61616344
40regulation of mast cell degranulation (GO:0043304)3.59446529
41B cell mediated immunity (GO:0019724)3.52975806
42response to muramyl dipeptide (GO:0032495)3.51354577
43detection of biotic stimulus (GO:0009595)3.49165674
44regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48761288
45regulation of antigen processing and presentation (GO:0002577)3.43250047
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.41811264
47response to host (GO:0075136)3.41811264
48response to host defenses (GO:0052200)3.41811264
49trophectodermal cell differentiation (GO:0001829)3.41250535
50neutrophil activation (GO:0042119)3.38928218
51negative regulation of leukocyte mediated immunity (GO:0002704)3.38579046
52regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.38021719
53myeloid cell activation involved in immune response (GO:0002275)3.37374576
54response to interleukin-15 (GO:0070672)3.36679143
55NIK/NF-kappaB signaling (GO:0038061)3.35170947
56microglial cell activation (GO:0001774)3.33678174
57macrophage activation (GO:0042116)3.31668295
58response to protozoan (GO:0001562)3.30419720
59regulation of mast cell activation involved in immune response (GO:0033006)3.29887354
60proline biosynthetic process (GO:0006561)3.29862981
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.29116227
62positive regulation of mast cell activation (GO:0033005)3.28983728
63positive regulation of protein homooligomerization (GO:0032464)3.25081930
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24898659
65negative regulation of erythrocyte differentiation (GO:0045647)3.24413112
66T-helper 1 type immune response (GO:0042088)3.22370559
67granulocyte activation (GO:0036230)3.21543349
68regulation of myeloid leukocyte mediated immunity (GO:0002886)3.17148483
69B cell homeostasis (GO:0001782)3.17105282
70negative regulation of T cell mediated immunity (GO:0002710)3.16973393
71cellular response to interleukin-15 (GO:0071350)3.15656554
72positive regulation of interferon-alpha production (GO:0032727)3.14632587
73positive regulation of antigen processing and presentation (GO:0002579)3.14218007
74regulation of skeletal muscle contraction (GO:0014819)3.13505486
75B cell receptor signaling pathway (GO:0050853)3.13322968
76positive regulation of gamma-delta T cell activation (GO:0046645)3.11834229
77regulation of leukocyte degranulation (GO:0043300)3.11775011
78regulation of T-helper 2 cell differentiation (GO:0045628)3.11635755
79regulation of gamma-delta T cell differentiation (GO:0045586)3.10835036
80regulation of integrin activation (GO:0033623)3.09912591
81production of molecular mediator involved in inflammatory response (GO:0002532)3.09315205
82regulation of mast cell activation (GO:0033003)3.07932815
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07502545
84lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01293304
85regulation of B cell receptor signaling pathway (GO:0050855)3.00768218
86regulation of interferon-alpha production (GO:0032647)2.99923116
87myeloid dendritic cell differentiation (GO:0043011)2.99637316
88negative regulation of phagocytosis (GO:0050765)2.98154815
89T cell migration (GO:0072678)2.95471166
90intestinal epithelial cell development (GO:0060576)2.94819451
91negative thymic T cell selection (GO:0045060)2.94218023
92negative regulation of alpha-beta T cell activation (GO:0046636)2.93260748
93negative regulation of innate immune response (GO:0045824)2.91361347
94determination of adult lifespan (GO:0008340)2.90204189
95myeloid dendritic cell activation (GO:0001773)2.90203641
96mitotic G1 DNA damage checkpoint (GO:0031571)2.88268084
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.87666741
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87250022
99regulation of interferon-beta biosynthetic process (GO:0045357)2.86848100
100mitotic G1/S transition checkpoint (GO:0044819)2.86766131
101positive regulation of type 2 immune response (GO:0002830)2.86756760
102regulation of alpha-beta T cell proliferation (GO:0046640)2.86264948
103protein localization to endosome (GO:0036010)2.85938289
104immunoglobulin mediated immune response (GO:0016064)2.84970027
105CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.84885173
106leukocyte migration involved in inflammatory response (GO:0002523)2.84079429
107negative regulation of cytokine production involved in immune response (GO:0002719)2.83589008
108positive regulation of histone deacetylation (GO:0031065)2.83173580
109maternal placenta development (GO:0001893)2.83057424
110regulation of gamma-delta T cell activation (GO:0046643)2.82913888
111tolerance induction (GO:0002507)2.82683390
112antigen processing and presentation via MHC class Ib (GO:0002475)2.82349009
113mitochondrial DNA metabolic process (GO:0032042)2.82313039
114negative regulation of potassium ion transmembrane transport (GO:1901380)2.82279004
115cellular response to interferon-gamma (GO:0071346)2.81794603
116formation of translation preinitiation complex (GO:0001731)2.80232887
117response to laminar fluid shear stress (GO:0034616)2.78836808
118positive regulation of lamellipodium assembly (GO:0010592)2.78653138
119actin-mediated cell contraction (GO:0070252)2.76405585
120antigen processing and presentation of endogenous antigen (GO:0019883)2.76364439
121regulation of B cell differentiation (GO:0045577)2.75187424
122positive regulation of B cell differentiation (GO:0045579)2.74915162
123pyrimidine ribonucleoside catabolic process (GO:0046133)2.71599892
124carnitine shuttle (GO:0006853)2.68925411
125regulation of translational fidelity (GO:0006450)2.67685860
126positive regulation of protein oligomerization (GO:0032461)2.67634335
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64595080
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.64595080
129myofibril assembly (GO:0030239)2.62466182
130retinoic acid receptor signaling pathway (GO:0048384)2.61349763
131positive thymic T cell selection (GO:0045059)2.60641275
132negative regulation of interleukin-12 production (GO:0032695)2.59899498
133positive regulation of SMAD protein import into nucleus (GO:0060391)2.57537506
134negative regulation of cell size (GO:0045792)2.57313148
135cellular response to osmotic stress (GO:0071470)2.56773654
136regulation of posttranscriptional gene silencing (GO:0060147)2.55954902
137regulation of gene silencing by miRNA (GO:0060964)2.55954902
138regulation of gene silencing by RNA (GO:0060966)2.55954902
139negative regulation of nucleotide catabolic process (GO:0030812)2.55470008
140embryonic process involved in female pregnancy (GO:0060136)2.53188169
141skeletal muscle contraction (GO:0003009)2.53158095
142regulation of translation in response to stress (GO:0043555)2.51588958
143positive regulation of protein deacetylation (GO:0090312)2.51410594
144cellular hyperosmotic response (GO:0071474)2.51313095
145muscle organ morphogenesis (GO:0048644)2.50584333
146heme transport (GO:0015886)2.49636874
147cardiac muscle cell development (GO:0055013)2.49554479
148negative regulation of stress fiber assembly (GO:0051497)2.49431495
149intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.48763912
150intracellular estrogen receptor signaling pathway (GO:0030520)2.47960830
151negative regulation of fatty acid biosynthetic process (GO:0045717)2.47953119
152mannose metabolic process (GO:0006013)2.47490915
153proline metabolic process (GO:0006560)2.44877627
154interferon-gamma secretion (GO:0072643)2.43127876
155negative regulation of toll-like receptor signaling pathway (GO:0034122)2.43086585
156regulation of superoxide anion generation (GO:0032928)2.42999832
157endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.42762253
158fatty acid transmembrane transport (GO:1902001)2.42248065
159apoptotic process involved in development (GO:1902742)2.41618413
160negative regulation of purine nucleotide catabolic process (GO:0033122)2.39131292
161biotin metabolic process (GO:0006768)2.39093937
162actin filament-based movement (GO:0030048)2.38776071
163low-density lipoprotein particle clearance (GO:0034383)2.36475758
164negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.36109810
165modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34989360
166positive regulation by organism of defense response of other organism involved in symbiotic interact2.34989360
167modulation by symbiont of host immune response (GO:0052553)2.34989360
168positive regulation by symbiont of host defense response (GO:0052509)2.34989360
169modulation by symbiont of host defense response (GO:0052031)2.34989360
170modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34989360
171plasma membrane repair (GO:0001778)2.34224799
172negative regulation of interleukin-8 production (GO:0032717)2.30716326
173pentose-phosphate shunt (GO:0006098)2.30262680
174mitochondrial fusion (GO:0008053)2.30259728
175positive regulation of lamellipodium organization (GO:1902745)2.29768422
176hypotonic response (GO:0006971)2.28742838
177negative regulation of interleukin-6 production (GO:0032715)2.28679969
178membrane raft organization (GO:0031579)2.27977534
179cardiac cell development (GO:0055006)2.27072500
180G1 DNA damage checkpoint (GO:0044783)2.26343032
181* embryonic placenta development (GO:0001892)2.25751968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26264144
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69246352
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68940657
4MYC_22102868_ChIP-Seq_BL_Human2.65405053
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.51575180
6* VDR_21846776_ChIP-Seq_THP-1_Human2.51126045
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43195174
8RUNX_20019798_ChIP-Seq_JUKART_Human2.23970803
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.11739219
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10355167
11E2F7_22180533_ChIP-Seq_HELA_Human2.07367007
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04956266
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04956266
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04956266
15SCL_19346495_ChIP-Seq_HPC-7_Human2.03462508
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02736263
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01114065
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95481303
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94087026
20STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92155018
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.90671896
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90244863
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.83518949
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82779936
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82692524
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.81358921
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.72593525
28* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68264765
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67681487
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65090825
31MAF_26560356_Chip-Seq_TH1_Human1.63505054
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.63424128
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63252280
34VDR_24787735_ChIP-Seq_THP-1_Human1.62447939
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.60968688
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.60926742
37LXR_22292898_ChIP-Seq_THP-1_Human1.60911130
38* KDM2B_26808549_Chip-Seq_DND41_Human1.60516748
39TCF7_22412390_ChIP-Seq_EML_Mouse1.59508291
40ZNF263_19887448_ChIP-Seq_K562_Human1.55994670
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55303008
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.53802677
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.53368428
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52992244
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51668298
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49896101
47* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49773887
48RACK7_27058665_Chip-Seq_MCF-7_Human1.48687842
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44894097
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.44536880
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43360939
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43172048
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42992408
54GATA3_27048872_Chip-Seq_THYMUS_Human1.42086810
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40447516
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38246252
57* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37830162
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37818074
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36232423
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35189195
61UTX_26944678_Chip-Seq_JUKART_Human1.35109704
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33851042
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33419943
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32865950
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30921342
66VDR_24763502_ChIP-Seq_THP-1_Human1.30381247
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28895246
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27554544
69MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26986968
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.26943175
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26397937
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25791828
73MAF_26560356_Chip-Seq_TH2_Human1.24779947
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24063915
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23631070
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22758962
77BCOR_27268052_Chip-Seq_Bcells_Human1.22314786
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22069883
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21946463
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20698253
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19965366
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19086961
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18551068
84PU_27001747_Chip-Seq_BMDM_Mouse1.18168134
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17772861
86IRF8_27001747_Chip-Seq_BMDM_Mouse1.16050444
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.15947555
88SPI1_23547873_ChIP-Seq_NB4_Human1.15493609
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14767369
90SPI1_23127762_ChIP-Seq_K562_Human1.14585774
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13426659
92ATF3_27146783_Chip-Seq_COLON_Human1.13399064
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13183032
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12632654
95MYB_26560356_Chip-Seq_TH1_Human1.11487081
96* NCOR1_26117541_ChIP-Seq_K562_Human1.11467157
97* KDM2B_26808549_Chip-Seq_JURKAT_Human1.11419972
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11344098
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.10609514
100MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09965807
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09738345
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09577901
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09451874
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09339577
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08369001
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.07531248
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06594838
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06548361
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05413338
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05398769
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05260914
112P68_20966046_ChIP-Seq_HELA_Human1.04955670
113MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04863840
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04646686
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04443915
116GATA1_19941826_ChIP-Seq_K562_Human1.04443826
117OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03799007
118TFEB_21752829_ChIP-Seq_HELA_Human1.03755382
119RXR_22158963_ChIP-Seq_LIVER_Mouse1.03679225
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03177053
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02703978
122* BCL6_27268052_Chip-Seq_Bcells_Human1.02649830
123PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02450700
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02264247
125CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02253171
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01502041
127CTCF_21964334_Chip-Seq_Bcells_Human1.01032287
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00944280
129KDM5A_27292631_Chip-Seq_BREAST_Human1.00098210
130CIITA_25753668_ChIP-Seq_RAJI_Human0.99886993
131TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99590836
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99467276
133* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99402306
134VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99112894
135GATA1_22025678_ChIP-Seq_K562_Human0.98457221
136SA1_27219007_Chip-Seq_ERYTHROID_Human0.97529864
137* GATA3_26560356_Chip-Seq_TH2_Human0.96931591
138* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94670335
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94496582
140MYB_26560356_Chip-Seq_TH2_Human0.93703874
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93413526
142SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93266113
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93074538
144HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92206281
145TET1_21451524_ChIP-Seq_MESCs_Mouse0.91798209
146SPI1_20517297_ChIP-Seq_HL60_Human0.91794957
147* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91573261
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.88739206
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88391413
150RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87533653
151CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87061418
152GATA2_21666600_ChIP-Seq_HMVEC_Human0.86183434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.61605753
2MP0009840_abnormal_foam_cell3.12906454
3MP0003646_muscle_fatigue2.93710186
4MP0009785_altered_susceptibility_to2.67392088
5MP0002148_abnormal_hypersensitivity_rea2.42737015
6MP0009278_abnormal_bone_marrow2.24462319
7MP0000749_muscle_degeneration2.23388484
8MP0003763_abnormal_thymus_physiology2.17344970
9MP0004084_abnormal_cardiac_muscle2.07281083
10MP0000747_muscle_weakness2.04832977
11MP0000750_abnormal_muscle_regeneration2.02829064
12MP0002269_muscular_atrophy2.00003992
13MP0003303_peritoneal_inflammation1.99814815
14MP0005058_abnormal_lysosome_morphology1.99639686
15MP0005330_cardiomyopathy1.99267509
16MP0008057_abnormal_DNA_replication1.97634207
17MP0000751_myopathy1.94964735
18MP0003705_abnormal_hypodermis_morpholog1.91155210
19MP0004087_abnormal_muscle_fiber1.90154995
20MP0002837_dystrophic_cardiac_calcinosis1.86185966
21MP0001800_abnormal_humoral_immune1.84811631
22MP0001533_abnormal_skeleton_physiology1.84601026
23MP0000685_abnormal_immune_system1.83878934
24MP0010155_abnormal_intestine_physiology1.81654020
25MP0004036_abnormal_muscle_relaxation1.81552143
26MP0005464_abnormal_platelet_physiology1.80202425
27MP0004185_abnormal_adipocyte_glucose1.77217814
28MP0003828_pulmonary_edema1.75589702
29MP0001835_abnormal_antigen_presentation1.73426189
30MP0005310_abnormal_salivary_gland1.71253219
31MP0004510_myositis1.71222892
32MP0003183_abnormal_peptide_metabolism1.70680158
33MP0002106_abnormal_muscle_physiology1.69512260
34MP0005387_immune_system_phenotype1.68578983
35MP0001790_abnormal_immune_system1.68578983
36MP0006082_CNS_inflammation1.62953869
37MP0010352_gastrointestinal_tract_polyps1.61716170
38MP0003806_abnormal_nucleotide_metabolis1.60331167
39MP0003566_abnormal_cell_adhesion1.60330092
40MP0002332_abnormal_exercise_endurance1.56105376
41MP0003191_abnormal_cellular_cholesterol1.51987370
42MP0010630_abnormal_cardiac_muscle1.50574316
43MP0002138_abnormal_hepatobiliary_system1.50482832
44MP0005451_abnormal_body_composition1.48893079
45MP0002452_abnormal_antigen_presenting1.46806484
46MP0008469_abnormal_protein_level1.43311435
47MP0000759_abnormal_skeletal_muscle1.42665693
48MP0003221_abnormal_cardiomyocyte_apopto1.42054592
49MP0004145_abnormal_muscle_electrophysio1.39956700
50MP0005666_abnormal_adipose_tissue1.39767239
51MP0004130_abnormal_muscle_cell1.38715978
52MP0003075_altered_response_to1.38457280
53MP0000689_abnormal_spleen_morphology1.36747796
54MP0004957_abnormal_blastocyst_morpholog1.31778914
55MP0009764_decreased_sensitivity_to1.30010324
56MP0002998_abnormal_bone_remodeling1.28626450
57MP0003950_abnormal_plasma_membrane1.27638489
58MP0002723_abnormal_immune_serum1.25093419
59MP0000465_gastrointestinal_hemorrhage1.25068401
60MP0002396_abnormal_hematopoietic_system1.23024156
61MP0002132_abnormal_respiratory_system1.21838560
62MP0002405_respiratory_system_inflammati1.21810171
63MP0005369_muscle_phenotype1.21485766
64MP0000703_abnormal_thymus_morphology1.20873681
65MP0003436_decreased_susceptibility_to1.19811702
66MP0000733_abnormal_muscle_development1.19701586
67MP0002420_abnormal_adaptive_immunity1.18821937
68MP0003453_abnormal_keratinocyte_physiol1.18409218
69MP0003866_abnormal_defecation1.18028490
70MP0001873_stomach_inflammation1.17122094
71MP0000343_altered_response_to1.16906938
72MP0005000_abnormal_immune_tolerance1.16839688
73MP0001819_abnormal_immune_cell1.16641987
74MP0002398_abnormal_bone_marrow1.16194012
75MP0002722_abnormal_immune_system1.16031899
76MP0003172_abnormal_lysosome_physiology1.16023887
77MP0005076_abnormal_cell_differentiation1.15201290
78MP0009333_abnormal_splenocyte_physiolog1.14655452
79MP0000858_altered_metastatic_potential1.14194661
80MP0000716_abnormal_immune_system1.13840807
81MP0005670_abnormal_white_adipose1.12161158
82MP0004381_abnormal_hair_follicle1.11881164
83MP0003111_abnormal_nucleus_morphology1.11149050
84MP0006036_abnormal_mitochondrial_physio1.10644983
85MP0005166_decreased_susceptibility_to1.10617520
86MP0005025_abnormal_response_to1.09916562
87MP0003690_abnormal_glial_cell1.09384933
88MP0005023_abnormal_wound_healing1.09080618
89MP0004233_abnormal_muscle_weight1.08096736
90MP0004947_skin_inflammation1.07179044
91MP0001730_embryonic_growth_arrest1.04882966
92MP0000604_amyloidosis1.04708466
93MP0005375_adipose_tissue_phenotype1.02973183
94MP0002429_abnormal_blood_cell1.02482876
95MP0003077_abnormal_cell_cycle1.00227154
96MP0002419_abnormal_innate_immunity0.98871177
97MP0003693_abnormal_embryo_hatching0.98382429
98MP0003984_embryonic_growth_retardation0.98309453
99MP0001672_abnormal_embryogenesis/_devel0.96661790
100MP0005380_embryogenesis_phenotype0.96661790
101MP0003045_fibrosis0.96173235
102MP0005397_hematopoietic_system_phenotyp0.95676288
103MP0001545_abnormal_hematopoietic_system0.95676288
104MP0002088_abnormal_embryonic_growth/wei0.95374482
105MP0001851_eye_inflammation0.93609749
106MP0001853_heart_inflammation0.92593286
107MP0002086_abnormal_extraembryonic_tissu0.91374770
108MP0005385_cardiovascular_system_phenoty0.91182158
109MP0001544_abnormal_cardiovascular_syste0.91182158
110MP0004883_abnormal_blood_vessel0.90791322
111MP0005266_abnormal_metabolism0.89347916
112MP0005075_abnormal_melanosome_morpholog0.86184963
113MP0002166_altered_tumor_susceptibility0.86159311
114MP0001663_abnormal_digestive_system0.85778207
115MP0005620_abnormal_muscle_contractility0.85726024
116MP0000609_abnormal_liver_physiology0.85377707
117MP0003300_gastrointestinal_ulcer0.84550913
118MP0005671_abnormal_response_to0.84284874
119MP0008004_abnormal_stomach_pH0.83650311
120MP0002277_abnormal_respiratory_mucosa0.83478331
121MP0003448_altered_tumor_morphology0.83453924
122MP0002019_abnormal_tumor_incidence0.83295019
123MP0002933_joint_inflammation0.82376107
124MP0008260_abnormal_autophagy0.81968552
125MP0003567_abnormal_fetal_cardiomyocyte0.81795170
126MP0008874_decreased_physiological_sensi0.81359065
127MP0003137_abnormal_impulse_conducting0.80862602
128MP0000490_abnormal_crypts_of0.79782887
129MP0001845_abnormal_inflammatory_respons0.78570149
130MP0008775_abnormal_heart_ventricle0.78052493
131MP0001697_abnormal_embryo_size0.78018576
132MP0003091_abnormal_cell_migration0.73288900
133MP0003656_abnormal_erythrocyte_physiolo0.71533566
134MP0000249_abnormal_blood_vessel0.69229711
135MP0009763_increased_sensitivity_to0.69212899
136MP0005390_skeleton_phenotype0.67465460
137MP0005164_abnormal_response_to0.64257127
138MP0005167_abnormal_blood-brain_barrier0.63696515
139MP0001986_abnormal_taste_sensitivity0.63620677
140MP0004808_abnormal_hematopoietic_stem0.63402643
141MP0003795_abnormal_bone_structure0.61347347
142MP0002006_tumorigenesis0.60323241
143MP0002254_reproductive_system_inflammat0.59369107
144MP0000920_abnormal_myelination0.58674596
145MP0002693_abnormal_pancreas_physiology0.56129299
146MP0000015_abnormal_ear_pigmentation0.49682822
147MP0005319_abnormal_enzyme/_coenzyme0.49053441

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)4.79792543
2Exercise-induced muscle cramps (HP:0003710)4.75358198
3Exercise-induced myalgia (HP:0003738)4.65191527
4Myositis (HP:0100614)4.54411355
5Mediastinal lymphadenopathy (HP:0100721)4.51962362
6Meningitis (HP:0001287)4.44169042
7Recurrent gram-negative bacterial infections (HP:0005420)4.39721810
8Orchitis (HP:0100796)4.33153196
9Retrobulbar optic neuritis (HP:0100654)4.12786503
10Optic neuritis (HP:0100653)4.12786503
11Difficulty running (HP:0009046)4.10356740
12Obstructive lung disease (HP:0006536)3.91171076
13Chronic obstructive pulmonary disease (HP:0006510)3.91171076
14Vasculitis (HP:0002633)3.89615472
15Stomatitis (HP:0010280)3.76130315
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.73480249
17Hyporeflexia of lower limbs (HP:0002600)3.64259373
18Muscle fiber inclusion bodies (HP:0100299)3.62531763
19Recurrent skin infections (HP:0001581)3.62144973
20Increased connective tissue (HP:0009025)3.60731243
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.52124526
22Elevated erythrocyte sedimentation rate (HP:0003565)3.49742640
23Gastrointestinal infarctions (HP:0005244)3.45543830
24Increased IgE level (HP:0003212)3.45525382
25Recurrent sinusitis (HP:0011108)3.43867198
26Chronic mucocutaneous candidiasis (HP:0002728)3.40280775
27Recurrent cutaneous fungal infections (HP:0011370)3.40280775
28Ventricular tachycardia (HP:0004756)3.37065618
29Asymmetric septal hypertrophy (HP:0001670)3.36380892
30Myopathic facies (HP:0002058)3.26686793
31Encephalitis (HP:0002383)3.26607328
32Myoglobinuria (HP:0002913)3.22571232
33Spontaneous hematomas (HP:0007420)3.20567429
34Muscle hypertrophy of the lower extremities (HP:0008968)3.19780510
35Urticaria (HP:0001025)3.18507936
36Lymphopenia (HP:0001888)3.18245106
37Pustule (HP:0200039)3.15978349
38Nemaline bodies (HP:0003798)3.15971149
39Ulnar bowing (HP:0003031)3.10498419
40Difficulty climbing stairs (HP:0003551)3.09814137
41Colitis (HP:0002583)3.09176170
42Pulmonary infiltrates (HP:0002113)3.06857404
43Calf muscle hypertrophy (HP:0008981)3.06186833
44Gingivitis (HP:0000230)3.04219039
45EMG: myopathic abnormalities (HP:0003458)3.03067761
46Chest pain (HP:0100749)3.02089276
47Round ear (HP:0100830)3.01256972
48Multiple enchondromatosis (HP:0005701)3.00862460
49Panhypogammaglobulinemia (HP:0003139)3.00787101
50Rhabdomyolysis (HP:0003201)3.00608816
51Sudden death (HP:0001699)2.92344734
52Ulnar deviation of the wrist (HP:0003049)2.92230384
53Osteomyelitis (HP:0002754)2.90607721
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.89792481
55Keratoconjunctivitis sicca (HP:0001097)2.89028922
56Cellulitis (HP:0100658)2.86757353
57Hemoptysis (HP:0002105)2.74030660
58Keratoconjunctivitis (HP:0001096)2.66703423
59Recurrent pneumonia (HP:0006532)2.59557746
60Progressive muscle weakness (HP:0003323)2.57328141
61Gastrointestinal stroma tumor (HP:0100723)2.54883124
62Recurrent abscess formation (HP:0002722)2.54417304
63Muscle stiffness (HP:0003552)2.53908932
64Inflammation of the large intestine (HP:0002037)2.51388488
65Type 1 muscle fiber predominance (HP:0003803)2.50788134
66Prolonged bleeding time (HP:0003010)2.49099591
67Testicular atrophy (HP:0000029)2.49096957
68Polycythemia (HP:0001901)2.43463028
69Sepsis (HP:0100806)2.43378818
70Gastrointestinal inflammation (HP:0004386)2.43012373
71Hypochromic anemia (HP:0001931)2.40806997
72Agammaglobulinemia (HP:0004432)2.40249260
73Recurrent lower respiratory tract infections (HP:0002783)2.38606199
74Loss of speech (HP:0002371)2.38498836
75Petechiae (HP:0000967)2.36399505
76Increased IgM level (HP:0003496)2.34719609
77Pulmonary embolism (HP:0002204)2.34593407
78EMG: neuropathic changes (HP:0003445)2.31970884
79Areflexia of lower limbs (HP:0002522)2.31795074
80Arterial thrombosis (HP:0004420)2.30719829
81Purpura (HP:0000979)2.30277666
82Abnormality of T cells (HP:0002843)2.30114992
83Abnormality of T cell physiology (HP:0011840)2.29390463
84Neck muscle weakness (HP:0000467)2.27376533
85Systemic lupus erythematosus (HP:0002725)2.25997635
86Epistaxis (HP:0000421)2.24022277
87Axonal loss (HP:0003447)2.23698251
88Chronic otitis media (HP:0000389)2.22475346
89Episodic fever (HP:0001954)2.22468402
90Papilloma (HP:0012740)2.22393436
91Verrucae (HP:0200043)2.22393436
92Recurrent fungal infections (HP:0002841)2.22301104
93Abnormality of the pleura (HP:0002103)2.21541020
94Abnormality of glycosphingolipid metabolism (HP:0004343)2.19522486
95Abnormality of glycolipid metabolism (HP:0010969)2.19522486
96Abnormality of liposaccharide metabolism (HP:0010968)2.19522486
97Distal arthrogryposis (HP:0005684)2.19506103
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.17505776
99IgM deficiency (HP:0002850)2.16037326
100T lymphocytopenia (HP:0005403)2.15500582
101Achilles tendon contracture (HP:0001771)2.15136195
102Abnormality of macrophages (HP:0004311)2.14792871
103Subaortic stenosis (HP:0001682)2.13897554
104Abnormality of the left ventricular outflow tract (HP:0011103)2.13897554
105Leukocytosis (HP:0001974)2.13063924
106Granulocytopenia (HP:0001913)2.12191400
107Distal lower limb muscle weakness (HP:0009053)2.10466229
108Hypochromic microcytic anemia (HP:0004840)2.10043953
109Hypoplastic ischia (HP:0003175)2.09481622
110Abnormality of T cell number (HP:0011839)2.09336898
111Hypergammaglobulinemia (HP:0010702)2.09209862
112Gingival bleeding (HP:0000225)2.08457260
113Abnormality of the peritoneum (HP:0002585)2.06776394
114Anorexia (HP:0002039)2.06671030
115Premature loss of primary teeth (HP:0006323)2.06178629
116Recurrent viral infections (HP:0004429)2.04937512
117Cerebral aneurysm (HP:0004944)2.04574922
118Abnormality of the endocardium (HP:0004306)2.04525609
119Eczematoid dermatitis (HP:0000976)2.04417288
120Paralysis (HP:0003470)2.04138256
121Arthralgia (HP:0002829)2.03362541
122Emphysema (HP:0002097)2.02881467
123Skin ulcer (HP:0200042)2.02732184
124Cheilitis (HP:0100825)2.02513523
125Recurrent bacterial skin infections (HP:0005406)2.01916562
126Viral hepatitis (HP:0006562)2.01166139
127Amyloidosis (HP:0011034)2.00949983
128Metaphyseal cupping (HP:0003021)2.00783511
129Restrictive lung disease (HP:0002091)2.00154610
130Abnormality of the Achilles tendon (HP:0005109)1.99268666
131Hyperglycinuria (HP:0003108)1.99248617
132Increased cerebral lipofuscin (HP:0011813)1.98253792
133Myocardial infarction (HP:0001658)1.97611255
134Skin rash (HP:0000988)1.97111177
135Abnormality of the calf musculature (HP:0001430)1.96886399
136Small epiphyses (HP:0010585)1.94907608
137Gangrene (HP:0100758)1.94711769
138Polyneuropathy (HP:0001271)1.94362490
139Cerebral hypomyelination (HP:0006808)1.93331846
140Abnormality of the salivary glands (HP:0010286)1.93251311
141IgA deficiency (HP:0002720)1.92754745
142Hepatosplenomegaly (HP:0001433)1.92010498
143Recurrent bronchitis (HP:0002837)1.91299106
144Vacuolated lymphocytes (HP:0001922)1.90225373
145Autoimmune thrombocytopenia (HP:0001973)1.90102990
146Lipoatrophy (HP:0100578)1.89618630
147Intestinal fistula (HP:0100819)1.89081058
148Rib fusion (HP:0000902)1.87522739
149Calcaneovalgus deformity (HP:0001848)1.86123868
150Diaphragmatic weakness (HP:0009113)1.85549924
151Rectovaginal fistula (HP:0000143)1.82241728
152Rectal fistula (HP:0100590)1.82241728
153Ependymoma (HP:0002888)1.79374333
154Frequent falls (HP:0002359)1.78910815
155Large for gestational age (HP:0001520)1.78518031
156Increased serum ferritin (HP:0003281)1.78510215
157Muscle fibrillation (HP:0010546)1.78158640
158Abnormality of glycine metabolism (HP:0010895)1.75703281
159Abnormality of serine family amino acid metabolism (HP:0010894)1.75703281
160Abnormality of the nasal mucosa (HP:0000433)1.75512918
161Dysostosis multiplex (HP:0000943)1.74810517
162Abnormality of skeletal muscle fiber size (HP:0012084)1.74343575
163Right ventricular cardiomyopathy (HP:0011663)1.74105187
164Vertebral clefting (HP:0008428)1.73689490
165Myotonia (HP:0002486)1.71694091
166Dilated cardiomyopathy (HP:0001644)1.71328350
167Vaginal fistula (HP:0004320)1.71232933
168Nasal polyposis (HP:0100582)1.70919512
169Abnormality of the umbilical cord (HP:0010881)1.70878327
170Generalized amyotrophy (HP:0003700)1.68257920
171Bundle branch block (HP:0011710)1.67353664
172Abnormality of the ischium (HP:0003174)1.67089864
173Ileus (HP:0002595)1.67044125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.91394034
2MAP4K13.74748840
3TTN3.14336372
4TRIB33.11599936
5IRAK43.00121937
6PRPF4B2.97887453
7MAP3K102.97315569
8ERN12.90217897
9ICK2.54496746
10CDK122.47071874
11EPHA22.21710122
12GRK62.18963440
13TNK22.16451965
14EPHB12.14127597
15STK102.11967970
16MAP3K142.11301169
17CSF1R1.92685693
18MAP3K131.91130416
19CSK1.89203491
20FES1.75600108
21OBSCN1.73339452
22SIK31.68262549
23PKN21.64125433
24IKBKE1.60806288
25MAP2K31.55157863
26MAP3K111.54833353
27PHKG11.54090660
28PHKG21.54090660
29BLK1.52247266
30SIK21.51196938
31TYK21.49314478
32MATK1.35921042
33TGFBR21.33385152
34FGR1.29177270
35BUB11.27572033
36SMG11.26365464
37LRRK21.25345045
38BCKDK1.21720625
39TAOK21.16555265
40MAP3K11.16380501
41NEK21.13948068
42TBK11.10188036
43FGFR41.07635314
44BMX1.07549454
45MAPK151.06766089
46JAK21.06738874
47RPS6KB21.05783761
48PAK41.05350986
49MARK21.03281247
50TYRO31.03122050
51TXK1.03105741
52EEF2K0.99148861
53NEK10.98556792
54BMPR20.98103688
55PIM10.96786419
56DDR20.96481620
57PINK10.94031530
58STK40.93659221
59KSR20.93621093
60CDK190.90933774
61DMPK0.90469885
62ALK0.90148190
63MAP3K30.89232922
64TESK20.86769311
65CDK40.84789787
66PRKD10.84226268
67MAPK120.83712886
68ITK0.83668401
69IRAK30.82493351
70MAPK110.82281613
71MAPK70.80722303
72MAP2K20.80254442
73MAP3K80.79597070
74TRPM70.79539288
75IRAK20.79340102
76KDR0.78712890
77PDK20.77941886
78MTOR0.77814628
79IKBKB0.77519803
80MARK30.77410035
81KIT0.74892561
82PRKD20.74814453
83IRAK10.74518205
84NEK90.73389490
85CDK70.73373672
86HCK0.72886843
87TAOK30.71757462
88PRKCQ0.71580548
89ZAP700.71373668
90PRKG20.70734005
91TTK0.67771942
92GSK3A0.67116022
93BTK0.64975298
94NME20.64914410
95SIK10.64719909
96TEC0.64077800
97MAPKAPK30.62382674
98DYRK30.61597205
99PIK3CG0.61429132
100WEE10.61372697
101JAK10.59618978
102MAP3K70.58822641
103PRKAA10.58336368
104GRK10.56576446
105PTK60.56467099
106HIPK20.56406787
107DYRK1B0.56011212
108YES10.55984715
109RPS6KC10.55035798
110RPS6KL10.55035798
111TAOK10.54962398
112CLK10.53914961
113RPS6KA60.53140509
114FYN0.52092780
115SYK0.52084702
116LCK0.51667235
117PDK30.51329388
118PDK40.51329388
119PRKAA20.51236586
120MAP2K60.51151219
121FGFR30.48680866
122PKN10.47635138
123CHUK0.47617183
124RIPK10.47406784
125CAMKK10.47093850
126ILK0.46411662
127MAP3K50.46399563
128LYN0.45883513
129CDC42BPA0.44931827
130MAPKAPK20.44165493
131MAP3K60.44057588
132JAK30.43212864
133STK110.43046039
134SGK30.43044310
135PRKCH0.42487923
136PDK10.42032052
137MAPK40.39693707
138EGFR0.39234069
139PDPK10.38693447
140PTK2B0.36929372
141DAPK20.34770655
142RPS6KA20.33762277
143GRK70.31943042
144ARAF0.30931536

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.36480941
2Autoimmune thyroid disease_Homo sapiens_hsa053203.12125096
3Graft-versus-host disease_Homo sapiens_hsa053323.10647338
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83938428
5B cell receptor signaling pathway_Homo sapiens_hsa046622.73729451
6Asthma_Homo sapiens_hsa053102.56000470
7Type I diabetes mellitus_Homo sapiens_hsa049402.50141226
8Primary immunodeficiency_Homo sapiens_hsa053402.41716292
9Vitamin B6 metabolism_Homo sapiens_hsa007502.31474769
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30193966
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96984823
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96077349
13Base excision repair_Homo sapiens_hsa034101.89378496
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86239501
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75199102
16Fructose and mannose metabolism_Homo sapiens_hsa000511.74133352
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73185859
18Mismatch repair_Homo sapiens_hsa034301.72794929
19Sulfur relay system_Homo sapiens_hsa041221.66663933
20Influenza A_Homo sapiens_hsa051641.59167865
21Carbon metabolism_Homo sapiens_hsa012001.55866303
22Biosynthesis of amino acids_Homo sapiens_hsa012301.54796499
23Rheumatoid arthritis_Homo sapiens_hsa053231.48253845
24DNA replication_Homo sapiens_hsa030301.44719653
25Lysosome_Homo sapiens_hsa041421.39401945
26Arginine and proline metabolism_Homo sapiens_hsa003301.37099739
27mTOR signaling pathway_Homo sapiens_hsa041501.36856596
28Pentose phosphate pathway_Homo sapiens_hsa000301.35562930
29Malaria_Homo sapiens_hsa051441.34953528
30Phagosome_Homo sapiens_hsa041451.34804864
31Viral myocarditis_Homo sapiens_hsa054161.34090724
32Chemokine signaling pathway_Homo sapiens_hsa040621.33415724
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31867792
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.30770392
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30682077
36Folate biosynthesis_Homo sapiens_hsa007901.30008427
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24123373
38Other glycan degradation_Homo sapiens_hsa005111.22574608
39Fatty acid biosynthesis_Homo sapiens_hsa000611.21258004
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20603488
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.20144498
42TNF signaling pathway_Homo sapiens_hsa046681.19933341
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.16778689
44Galactose metabolism_Homo sapiens_hsa000521.16568778
45Osteoclast differentiation_Homo sapiens_hsa043801.14357937
46Leishmaniasis_Homo sapiens_hsa051401.12795744
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12782450
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11405510
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10359387
50Staphylococcus aureus infection_Homo sapiens_hsa051501.06917900
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06884982
52Insulin resistance_Homo sapiens_hsa049311.06131831
53Fatty acid metabolism_Homo sapiens_hsa012121.05957462
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05955774
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04422041
56Shigellosis_Homo sapiens_hsa051311.03824249
57Hepatitis B_Homo sapiens_hsa051611.03594206
58Acute myeloid leukemia_Homo sapiens_hsa052211.03229481
59Hepatitis C_Homo sapiens_hsa051601.02426353
60Adipocytokine signaling pathway_Homo sapiens_hsa049201.01313185
61Notch signaling pathway_Homo sapiens_hsa043301.00565502
62Antigen processing and presentation_Homo sapiens_hsa046120.95538001
63Pertussis_Homo sapiens_hsa051330.94584137
64VEGF signaling pathway_Homo sapiens_hsa043700.93653607
65Propanoate metabolism_Homo sapiens_hsa006400.93027307
66Apoptosis_Homo sapiens_hsa042100.90197972
67Arginine biosynthesis_Homo sapiens_hsa002200.89496282
68Fatty acid degradation_Homo sapiens_hsa000710.88743789
69African trypanosomiasis_Homo sapiens_hsa051430.88283788
70RNA transport_Homo sapiens_hsa030130.87690129
71Non-small cell lung cancer_Homo sapiens_hsa052230.87609779
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.86344887
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86303198
74Lysine degradation_Homo sapiens_hsa003100.83258502
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83019495
76Platelet activation_Homo sapiens_hsa046110.83018819
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81638231
78AMPK signaling pathway_Homo sapiens_hsa041520.81207445
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.81179554
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80002747
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79690679
82Dilated cardiomyopathy_Homo sapiens_hsa054140.78833704
83Salmonella infection_Homo sapiens_hsa051320.74533786
84Viral carcinogenesis_Homo sapiens_hsa052030.74077884
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73469191
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73074395
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.72971739
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72715441
89Epstein-Barr virus infection_Homo sapiens_hsa051690.72442096
90Small cell lung cancer_Homo sapiens_hsa052220.70246668
91p53 signaling pathway_Homo sapiens_hsa041150.70215866
92Pancreatic cancer_Homo sapiens_hsa052120.70007060
93Legionellosis_Homo sapiens_hsa051340.69821634
94Starch and sucrose metabolism_Homo sapiens_hsa005000.69758512
95Endocytosis_Homo sapiens_hsa041440.69197915
96Hematopoietic cell lineage_Homo sapiens_hsa046400.68583564
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68144197
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.66933025
99Insulin signaling pathway_Homo sapiens_hsa049100.66621555
100Prolactin signaling pathway_Homo sapiens_hsa049170.65170360
101Regulation of autophagy_Homo sapiens_hsa041400.63397330
102Renal cell carcinoma_Homo sapiens_hsa052110.63394397
103Tuberculosis_Homo sapiens_hsa051520.63370846
104Tight junction_Homo sapiens_hsa045300.63122753
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63092101
106Caffeine metabolism_Homo sapiens_hsa002320.62415033
107Herpes simplex infection_Homo sapiens_hsa051680.62385828
108PPAR signaling pathway_Homo sapiens_hsa033200.61979259
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61481117
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60981496
111HIF-1 signaling pathway_Homo sapiens_hsa040660.60756273
112GnRH signaling pathway_Homo sapiens_hsa049120.60730419
113Chronic myeloid leukemia_Homo sapiens_hsa052200.60415775
114Toxoplasmosis_Homo sapiens_hsa051450.58879992
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58426214
116Measles_Homo sapiens_hsa051620.57667199
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56154634
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.56037935
119Focal adhesion_Homo sapiens_hsa045100.55467061
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54893070
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54813780
122Nitrogen metabolism_Homo sapiens_hsa009100.53051854
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52344466
124Adherens junction_Homo sapiens_hsa045200.52183442
125Proteoglycans in cancer_Homo sapiens_hsa052050.52073691
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51375228
127Cardiac muscle contraction_Homo sapiens_hsa042600.50811031
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49734146
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.49726577
130Systemic lupus erythematosus_Homo sapiens_hsa053220.49435456
131T cell receptor signaling pathway_Homo sapiens_hsa046600.49425012
132MicroRNAs in cancer_Homo sapiens_hsa052060.49403644
133Spliceosome_Homo sapiens_hsa030400.47689946
134MAPK signaling pathway_Homo sapiens_hsa040100.46780930
135Nucleotide excision repair_Homo sapiens_hsa034200.46760680
136HTLV-I infection_Homo sapiens_hsa051660.46115290
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.43799504
138FoxO signaling pathway_Homo sapiens_hsa040680.43490363
139beta-Alanine metabolism_Homo sapiens_hsa004100.43446984
140Fatty acid elongation_Homo sapiens_hsa000620.42595091
141Ribosome_Homo sapiens_hsa030100.42238939
142Glycerolipid metabolism_Homo sapiens_hsa005610.39926937
143Choline metabolism in cancer_Homo sapiens_hsa052310.39619757
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39187173
145Endometrial cancer_Homo sapiens_hsa052130.37458717
146Type II diabetes mellitus_Homo sapiens_hsa049300.36637067
147Inositol phosphate metabolism_Homo sapiens_hsa005620.35879572
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34469304
149Amoebiasis_Homo sapiens_hsa051460.34229175
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32292705
151Dorso-ventral axis formation_Homo sapiens_hsa043200.28503329
152Colorectal cancer_Homo sapiens_hsa052100.25317743
153Collecting duct acid secretion_Homo sapiens_hsa049660.25057640
154Bladder cancer_Homo sapiens_hsa052190.23547323
155Estrogen signaling pathway_Homo sapiens_hsa049150.22877315
156Long-term potentiation_Homo sapiens_hsa047200.22638171
157Rap1 signaling pathway_Homo sapiens_hsa040150.20989274

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