TFEC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)5.67397320
2positive regulation of chemokine biosynthetic process (GO:0045080)5.32834790
3regulation of vitamin D biosynthetic process (GO:0060556)5.16196284
4neutrophil activation involved in immune response (GO:0002283)5.14689564
5positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.10578276
6negative regulation of interleukin-12 production (GO:0032695)5.09970530
7positive regulation by symbiont of host defense response (GO:0052509)5.03769245
8modulation by symbiont of host defense response (GO:0052031)5.03769245
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.03769245
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.03769245
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.03769245
12modulation by symbiont of host immune response (GO:0052553)5.03769245
13regulation of chemokine biosynthetic process (GO:0045073)5.03169992
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93788111
15positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.81554090
16leukocyte aggregation (GO:0070486)4.78411045
17positive regulation of heat generation (GO:0031652)4.78025965
18neutrophil mediated immunity (GO:0002446)4.75164691
19positive regulation of interferon-alpha production (GO:0032727)4.60486509
20regulation of vitamin metabolic process (GO:0030656)4.56775996
21regulation of fever generation (GO:0031620)4.55231628
22response to muramyl dipeptide (GO:0032495)4.50433985
23lipopolysaccharide-mediated signaling pathway (GO:0031663)4.47343096
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.41988773
25regulation of interferon-alpha production (GO:0032647)4.35382070
26respiratory burst (GO:0045730)4.31351537
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.30666598
28regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.26209488
29immunoglobulin mediated immune response (GO:0016064)3.95405846
30macrophage activation involved in immune response (GO:0002281)3.94189009
31detection of other organism (GO:0098543)3.93265780
32regulation of histone phosphorylation (GO:0033127)3.91658835
33reactive oxygen species biosynthetic process (GO:1903409)3.82170422
34T-helper 1 type immune response (GO:0042088)3.81249561
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.80006878
36regulation of T-helper 1 cell differentiation (GO:0045625)3.78635770
37leukocyte mediated cytotoxicity (GO:0001909)3.78357198
38interferon-gamma-mediated signaling pathway (GO:0060333)3.70983258
39myeloid leukocyte mediated immunity (GO:0002444)3.70625120
40regulation of gamma-delta T cell activation (GO:0046643)3.69046693
41granulocyte activation (GO:0036230)3.67908070
42negative regulation of cell killing (GO:0031342)3.62699608
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62699608
44cellular extravasation (GO:0045123)3.60069682
45regulation of heat generation (GO:0031650)3.59800838
46natural killer cell mediated immunity (GO:0002228)3.55859415
47natural killer cell mediated cytotoxicity (GO:0042267)3.55859415
48hydrogen peroxide biosynthetic process (GO:0050665)3.54178893
49detection of bacterium (GO:0016045)3.52074242
50superoxide anion generation (GO:0042554)3.50556371
51cytokine secretion (GO:0050663)3.50353769
52microglial cell activation (GO:0001774)3.49903786
53detection of external biotic stimulus (GO:0098581)3.49455257
54myeloid cell activation involved in immune response (GO:0002275)3.46846358
55neutrophil activation (GO:0042119)3.44728413
56modulation of growth of symbiont involved in interaction with host (GO:0044144)3.44205647
57regulation of growth of symbiont in host (GO:0044126)3.44205647
58negative regulation of growth of symbiont in host (GO:0044130)3.44205647
59negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.44205647
60defense response to protozoan (GO:0042832)3.41145137
61B cell mediated immunity (GO:0019724)3.40408463
62positive regulation of interferon-beta production (GO:0032728)3.38987986
63cellular response to interferon-beta (GO:0035458)3.38606622
64regulation of B cell receptor signaling pathway (GO:0050855)3.37453422
65production of molecular mediator involved in inflammatory response (GO:0002532)3.37332582
66positive regulation of type 2 immune response (GO:0002830)3.36706314
67regulation of heterotypic cell-cell adhesion (GO:0034114)3.35052996
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.33775257
69macrophage activation (GO:0042116)3.33015883
70regulation of interferon-beta biosynthetic process (GO:0045357)3.31015852
71positive regulation of gamma-delta T cell activation (GO:0046645)3.30071989
72cellular response to thyroid hormone stimulus (GO:0097067)3.29845637
73response to host immune response (GO:0052572)3.29426950
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29426950
75negative regulation of erythrocyte differentiation (GO:0045647)3.28930918
76positive regulation of antigen processing and presentation (GO:0002579)3.26197674
77regulation of antigen processing and presentation (GO:0002577)3.25895270
78myeloid dendritic cell activation (GO:0001773)3.24926576
79glycosphingolipid catabolic process (GO:0046479)3.24491870
80response to interferon-beta (GO:0035456)3.23863107
81oligosaccharide catabolic process (GO:0009313)3.23589323
82regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22961521
83positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.22326607
84positive regulation of NF-kappaB import into nucleus (GO:0042346)3.20376882
85regulation of interleukin-8 biosynthetic process (GO:0045414)3.19524817
86myeloid dendritic cell differentiation (GO:0043011)3.18861822
87regulation of mast cell degranulation (GO:0043304)3.18564161
88cellular response to zinc ion (GO:0071294)3.17791588
89detection of biotic stimulus (GO:0009595)3.17600421
90positive regulation of B cell differentiation (GO:0045579)3.16341340
91germinal center formation (GO:0002467)3.16058300
92T cell migration (GO:0072678)3.15506321
93regulation of leukocyte degranulation (GO:0043300)3.10933795
94pinocytosis (GO:0006907)3.10576985
95regulation of myeloid leukocyte mediated immunity (GO:0002886)3.10180090
96neutrophil chemotaxis (GO:0030593)3.08122086
97positive regulation of chemokine production (GO:0032722)3.06222446
98positive regulation of prostaglandin secretion (GO:0032308)3.05462583
99positive regulation of mast cell degranulation (GO:0043306)3.05115190
100positive regulation of mast cell activation involved in immune response (GO:0033008)3.05115190
101regulation of tolerance induction (GO:0002643)3.05062542
102response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05010391
103response to host (GO:0075136)3.05010391
104response to host defenses (GO:0052200)3.05010391
105antigen processing and presentation of endogenous antigen (GO:0019883)3.04103755
106regulation of interleukin-12 production (GO:0032655)3.02132020
107response to protozoan (GO:0001562)3.01658354
108neutrophil migration (GO:1990266)3.01366913
109regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.01070682
110positive regulation of cellular amide metabolic process (GO:0034250)3.00388318
111positive regulation of toll-like receptor signaling pathway (GO:0034123)3.00181563
112cellular response to virus (GO:0098586)2.99458147
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98739695
114disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.98584496
115killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.98584496
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98577925
117positive regulation of mast cell activation (GO:0033005)2.98376282
118positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.97182610
119negative regulation of interleukin-17 production (GO:0032700)2.96893304
120regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.96176363
121regulation of mast cell activation (GO:0033003)2.95684373
122cellular response to interferon-gamma (GO:0071346)2.95100265
123positive regulation of leukocyte degranulation (GO:0043302)2.94845012
124negative regulation of cytokine production involved in immune response (GO:0002719)2.94773188
125regulation of mast cell activation involved in immune response (GO:0033006)2.94463395
126regulation of gamma-delta T cell differentiation (GO:0045586)2.94431945
127detection of molecule of bacterial origin (GO:0032490)2.93408770
128positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.93274794
129regulation of T cell tolerance induction (GO:0002664)2.93018429
130positive regulation of T-helper 1 type immune response (GO:0002827)2.92289927
131positive regulation of alpha-beta T cell proliferation (GO:0046641)2.92253525
132positive regulation of tumor necrosis factor production (GO:0032760)2.92109554
133positive regulation of interleukin-2 production (GO:0032743)2.91761281
134type I interferon signaling pathway (GO:0060337)2.91555856
135cellular response to type I interferon (GO:0071357)2.91555856
136regulation of activation of Janus kinase activity (GO:0010533)2.91524385
137glycolipid catabolic process (GO:0019377)2.90995627
138regulation of prostaglandin secretion (GO:0032306)2.90234367
139response to type I interferon (GO:0034340)2.88693898
140positive regulation of interleukin-12 production (GO:0032735)2.88251622
141positive regulation of interleukin-6 production (GO:0032755)2.88081622
142positive regulation of T-helper cell differentiation (GO:0045624)2.87562813
143positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.86644654
144negative regulation of T cell mediated immunity (GO:0002710)2.83066518
145regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.82116352
146regulation of interleukin-17 production (GO:0032660)2.80412682
147antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79523552
148regulation of mononuclear cell migration (GO:0071675)2.79370065
149response to interferon-gamma (GO:0034341)2.76639809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.38940312
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.49029978
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.73508043
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.21069549
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.18558101
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.96675916
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.93340621
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82155450
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.76405162
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.65544126
11SCL_19346495_ChIP-Seq_HPC-7_Human3.16004284
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12094658
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01267975
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.95200186
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92862498
16GATA1_22025678_ChIP-Seq_K562_Human2.91009956
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.71195965
18* SPI1_23547873_ChIP-Seq_NB4_Human2.55204233
19E2F7_22180533_ChIP-Seq_HELA_Human2.45113679
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44641967
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44167465
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.43018506
23BRD4_27068464_Chip-Seq_AML-cells_Mouse2.42516683
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31433103
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21070911
26VDR_24763502_ChIP-Seq_THP-1_Human2.15892568
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01197608
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.97804655
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.93870561
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92572272
31PU_27001747_Chip-Seq_BMDM_Mouse1.88793403
32MYB_26560356_Chip-Seq_TH2_Human1.88679854
33VDR_21846776_ChIP-Seq_THP-1_Human1.86998322
34SPI1_23127762_ChIP-Seq_K562_Human1.86670425
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80373101
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78105423
37CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76060399
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73350108
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72221317
40RUNX_20019798_ChIP-Seq_JUKART_Human1.71425634
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70154544
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67511389
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65096532
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62429088
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.54869894
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54207014
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52610924
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51180472
49CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.49818404
50MAF_26560356_Chip-Seq_TH1_Human1.46404531
51MYB_26560356_Chip-Seq_TH1_Human1.43768967
52SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41753959
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39006951
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38979001
55VDR_24787735_ChIP-Seq_THP-1_Human1.36483312
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31416055
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25153307
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22298974
59UTX_26944678_Chip-Seq_JUKART_Human1.20590629
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16607806
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15928114
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.15322482
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15207629
64GATA3_26560356_Chip-Seq_TH2_Human1.14695245
65GATA3_27048872_Chip-Seq_THYMUS_Human1.10687053
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09916659
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09907713
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09862105
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06630426
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03148264
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01212241
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00113076
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99484193
74TCF7_22412390_ChIP-Seq_EML_Mouse0.98495862
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97267572
76MYC_22102868_ChIP-Seq_BL_Human0.97158679
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97134686
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94358437
79KDM2B_26808549_Chip-Seq_DND41_Human0.93505534
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.91337744
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88207930
82TFEB_21752829_ChIP-Seq_HELA_Human0.87916473
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87902787
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87135747
85STAT1_20625510_ChIP-Seq_HELA_Human0.85194509
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84397981
87GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83186242
88MAF_26560356_Chip-Seq_TH2_Human0.81488121
89FOXM1_23109430_ChIP-Seq_U2OS_Human0.79994509
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.79644375
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78982004
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75160411
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73600594
94TP63_17297297_ChIP-ChIP_HaCaT_Human0.72610584
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71770309
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71006915
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69820462
98* SMRT_27268052_Chip-Seq_Bcells_Human0.69351874
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.67634359
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66529167
101NCOR1_26117541_ChIP-Seq_K562_Human0.66356004
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.66239148
103GATA2_19941826_ChIP-Seq_K562_Human0.66133299
104ETS1_22383799_ChIP-Seq_G1ME_Mouse0.66089986
105BCL6_27268052_Chip-Seq_Bcells_Human0.64589586
106IGF1R_20145208_ChIP-Seq_DFB_Human0.64415513
107SPI1_20517297_ChIP-Seq_HL60_Human0.61920170
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.59779833
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59234511
110P300_27268052_Chip-Seq_Bcells_Human0.59022144
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.58187490
112* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.57774068
113ELK1_19687146_ChIP-ChIP_HELA_Human0.57477721
114ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.57328090
115LXR_22158963_ChIP-Seq_LIVER_Mouse0.57037103
116GATA1_19941826_ChIP-Seq_K562_Human0.56441613
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.55580998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.18865347
2MP0001835_abnormal_antigen_presentation4.13336920
3MP0003436_decreased_susceptibility_to3.73981743
4MP0002148_abnormal_hypersensitivity_rea3.60872537
5MP0002419_abnormal_innate_immunity3.41573230
6MP0005000_abnormal_immune_tolerance3.17411435
7MP0005025_abnormal_response_to3.13944225
8MP0003303_peritoneal_inflammation3.10550819
9MP0003724_increased_susceptibility_to2.85746107
10MP0006082_CNS_inflammation2.71442018
11MP0005464_abnormal_platelet_physiology2.64236417
12MP0002452_abnormal_antigen_presenting2.61187811
13MP0005058_abnormal_lysosome_morphology2.60098601
14MP0002723_abnormal_immune_serum2.49328763
15MP0000569_abnormal_digit_pigmentation2.48349238
16MP0002006_tumorigenesis2.37033261
17MP0001800_abnormal_humoral_immune2.35996819
18MP0001790_abnormal_immune_system2.31859300
19MP0005387_immune_system_phenotype2.31859300
20MP0001819_abnormal_immune_cell2.26125628
21MP0005174_abnormal_tail_pigmentation2.24537566
22MP0002420_abnormal_adaptive_immunity2.24120148
23MP0003172_abnormal_lysosome_physiology2.23461341
24MP0005671_abnormal_response_to2.18239011
25MP0000685_abnormal_immune_system2.14524806
26MP0005167_abnormal_blood-brain_barrier2.12300901
27MP0009764_decreased_sensitivity_to2.10997625
28MP0000858_altered_metastatic_potential2.06005674
29MP0009278_abnormal_bone_marrow2.01226222
30MP0004510_myositis1.95474977
31MP0001845_abnormal_inflammatory_respons1.94927033
32MP0004947_skin_inflammation1.94352710
33MP0003448_altered_tumor_morphology1.92265342
34MP0003300_gastrointestinal_ulcer1.86933055
35MP0003183_abnormal_peptide_metabolism1.85914049
36MP0001533_abnormal_skeleton_physiology1.82313007
37MP0001853_heart_inflammation1.82066551
38MP0005397_hematopoietic_system_phenotyp1.78325032
39MP0001545_abnormal_hematopoietic_system1.78325032
40MP0002405_respiratory_system_inflammati1.77978794
41MP0008469_abnormal_protein_level1.77320320
42MP0010155_abnormal_intestine_physiology1.77098021
43MP0000343_altered_response_to1.76545787
44MP0009333_abnormal_splenocyte_physiolog1.71367199
45MP0000716_abnormal_immune_system1.65648386
46MP0002398_abnormal_bone_marrow1.62480432
47MP0002139_abnormal_hepatobiliary_system1.54549552
48MP0008004_abnormal_stomach_pH1.47228075
49MP0003806_abnormal_nucleotide_metabolis1.43934630
50MP0003191_abnormal_cellular_cholesterol1.40773094
51MP0002429_abnormal_blood_cell1.38278718
52MP0000689_abnormal_spleen_morphology1.37814384
53MP0003075_altered_response_to1.36373987
54MP0005451_abnormal_body_composition1.35934124
55MP0002722_abnormal_immune_system1.33737884
56MP0002998_abnormal_bone_remodeling1.31362352
57MP0000015_abnormal_ear_pigmentation1.29744006
58MP0009840_abnormal_foam_cell1.28173798
59MP0005166_decreased_susceptibility_to1.27537235
60MP0000490_abnormal_crypts_of1.24070399
61MP0003186_abnormal_redox_activity1.23061758
62MP0002396_abnormal_hematopoietic_system1.21972923
63MP0004808_abnormal_hematopoietic_stem1.18328803
64MP0009763_increased_sensitivity_to1.14576880
65MP0005310_abnormal_salivary_gland1.12622215
66MP0003828_pulmonary_edema1.03343522
67MP0003690_abnormal_glial_cell1.02505018
68MP0006054_spinal_hemorrhage1.02085374
69MP0001851_eye_inflammation1.01275017
70MP0002166_altered_tumor_susceptibility1.00978582
71MP0000604_amyloidosis1.00795629
72MP0003656_abnormal_erythrocyte_physiolo0.98075762
73MP0005164_abnormal_response_to0.97846532
74MP0000371_diluted_coat_color0.89786208
75MP0000249_abnormal_blood_vessel0.88344837
76MP0002332_abnormal_exercise_endurance0.88179516
77MP0000465_gastrointestinal_hemorrhage0.87838144
78MP0003763_abnormal_thymus_physiology0.87251846
79MP0010307_abnormal_tumor_latency0.85102622
80MP0003195_calcinosis0.83424892
81MP0002138_abnormal_hepatobiliary_system0.81264627
82MP0004782_abnormal_surfactant_physiolog0.80897456
83MP0001873_stomach_inflammation0.80827617
84MP0005390_skeleton_phenotype0.79481028
85MP0005075_abnormal_melanosome_morpholog0.78333502
86MP0009765_abnormal_xenobiotic_induced0.74909645
87MP0003566_abnormal_cell_adhesion0.74711808
88MP0010352_gastrointestinal_tract_polyps0.73871632
89MP0003866_abnormal_defecation0.73843844
90MP0000703_abnormal_thymus_morphology0.73621813
91MP0002933_joint_inflammation0.73075484
92MP0008260_abnormal_autophagy0.70219263
93MP0002136_abnormal_kidney_physiology0.69781649
94MP0005076_abnormal_cell_differentiation0.68596905
95MP0002095_abnormal_skin_pigmentation0.68128401
96MP0005165_increased_susceptibility_to0.66578409
97MP0005319_abnormal_enzyme/_coenzyme0.66364127
98MP0003329_amyloid_beta_deposits0.64043750
99MP0003091_abnormal_cell_migration0.62479061
100MP0003453_abnormal_keratinocyte_physiol0.61033112
101MP0008873_increased_physiological_sensi0.60869336
102MP0008874_decreased_physiological_sensi0.60704720
103MP0001663_abnormal_digestive_system0.60232748
104MP0004883_abnormal_blood_vessel0.59947524
105MP0002254_reproductive_system_inflammat0.59119635
106MP0003795_abnormal_bone_structure0.58977975
107MP0002277_abnormal_respiratory_mucosa0.58822745
108MP0005647_abnormal_sex_gland0.58275026
109MP0002877_abnormal_melanocyte_morpholog0.56578445
110MP0002019_abnormal_tumor_incidence0.55961828
111MP0000920_abnormal_myelination0.55755125
112MP0000609_abnormal_liver_physiology0.53852691
113MP0003221_abnormal_cardiomyocyte_apopto0.50305902
114MP0005535_abnormal_body_temperature0.49575694
115MP0000598_abnormal_liver_morphology0.48910564

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.17785835
2Eczematoid dermatitis (HP:0000976)6.94623351
3Recurrent bacterial skin infections (HP:0005406)6.59267467
4Elevated erythrocyte sedimentation rate (HP:0003565)5.84321205
5Recurrent gram-negative bacterial infections (HP:0005420)5.63898102
6Mediastinal lymphadenopathy (HP:0100721)5.22126722
7Stomatitis (HP:0010280)4.80830137
8Abnormality of macrophages (HP:0004311)4.74155764
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.61690260
10Increased cerebral lipofuscin (HP:0011813)4.58754770
11Myositis (HP:0100614)4.49120076
12Vacuolated lymphocytes (HP:0001922)4.30256533
13Recurrent skin infections (HP:0001581)4.13086122
14Orchitis (HP:0100796)3.95673678
15Gingivitis (HP:0000230)3.85283342
16Recurrent fungal infections (HP:0002841)3.79530253
17Obstructive lung disease (HP:0006536)3.76339942
18Chronic obstructive pulmonary disease (HP:0006510)3.76339942
19Autoimmune thrombocytopenia (HP:0001973)3.67492400
20Retrobulbar optic neuritis (HP:0100654)3.63697043
21Optic neuritis (HP:0100653)3.63697043
22Vasculitis (HP:0002633)3.59032377
23Periodontitis (HP:0000704)3.49927398
24Loss of speech (HP:0002371)3.49885595
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.48707754
26Interstitial pulmonary disease (HP:0006530)3.34088012
27Petechiae (HP:0000967)3.32214182
28Prostate neoplasm (HP:0100787)3.31183948
29Cellulitis (HP:0100658)3.26723945
30Basal ganglia calcification (HP:0002135)3.18915427
31Neoplasm of head and neck (HP:0012288)3.15919747
32Esophageal neoplasm (HP:0100751)3.15919747
33Recurrent viral infections (HP:0004429)3.10831599
34Systemic lupus erythematosus (HP:0002725)3.07599832
35Thrombocytosis (HP:0001894)2.97430358
36Abnormality of the prostate (HP:0008775)2.95503779
37Recurrent cutaneous fungal infections (HP:0011370)2.88122767
38Chronic mucocutaneous candidiasis (HP:0002728)2.88122767
39Urticaria (HP:0001025)2.85626596
40Leukocytosis (HP:0001974)2.84039095
41Encephalitis (HP:0002383)2.83992498
42Meningitis (HP:0001287)2.79675031
43Axonal loss (HP:0003447)2.76246438
44Gastrointestinal infarctions (HP:0005244)2.76041136
45Abnormality of the vasculature of the conjunctiva (HP:0008054)2.75914260
46Disinhibition (HP:0000734)2.75788400
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.74938454
48T lymphocytopenia (HP:0005403)2.73016130
49Mutism (HP:0002300)2.72525339
50Gingival bleeding (HP:0000225)2.69859778
51Pulmonary infiltrates (HP:0002113)2.69207938
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.67853311
53Myocardial infarction (HP:0001658)2.64446561
54Osteomyelitis (HP:0002754)2.63621457
55Premature loss of primary teeth (HP:0006323)2.62577117
56Agnosia (HP:0010524)2.58579577
57Abnormality of T cell number (HP:0011839)2.58548710
58Pustule (HP:0200039)2.51109351
59Joint hemorrhage (HP:0005261)2.50804527
60Epistaxis (HP:0000421)2.49180000
61Hypergammaglobulinemia (HP:0010702)2.47363005
62Recurrent pneumonia (HP:0006532)2.44352309
63Amyloidosis (HP:0011034)2.41809524
64Hemoptysis (HP:0002105)2.41226081
65Arterial thrombosis (HP:0004420)2.39710615
66Abnormality of glycolipid metabolism (HP:0010969)2.37406606
67Abnormality of liposaccharide metabolism (HP:0010968)2.37406606
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.37406606
69Pulmonary embolism (HP:0002204)2.33054456
70Tetraparesis (HP:0002273)2.31652531
71Inflammation of the large intestine (HP:0002037)2.28699929
72Panhypogammaglobulinemia (HP:0003139)2.26616489
73Dysostosis multiplex (HP:0000943)2.26365012
74Bone pain (HP:0002653)2.24614987
75Increased serum ferritin (HP:0003281)2.24540178
76Eosinophilia (HP:0001880)2.23428873
77Keratoconjunctivitis sicca (HP:0001097)2.22667526
78Parakeratosis (HP:0001036)2.19845510
79Albinism (HP:0001022)2.19514557
80Autoimmune hemolytic anemia (HP:0001890)2.19462738
81Amaurosis fugax (HP:0100576)2.18068560
82Gastrointestinal inflammation (HP:0004386)2.14276909
83Recurrent lower respiratory tract infections (HP:0002783)2.13377861
84Abnormality of the pleura (HP:0002103)2.08349113
85Neurofibrillary tangles (HP:0002185)2.08280066
86Prolonged bleeding time (HP:0003010)2.06846030
87Abnormality of the periventricular white matter (HP:0002518)2.06423591
88Hepatosplenomegaly (HP:0001433)2.05607288
89Diminished motivation (HP:0000745)2.04478820
90Apathy (HP:0000741)2.02481051
91Thick nail (HP:0001805)2.02355246
92Abnormality of T cells (HP:0002843)2.02282660
93Granulocytopenia (HP:0001913)2.01650668
94Abnormality of iron homeostasis (HP:0011031)2.01631521
95Agammaglobulinemia (HP:0004432)2.01064741
96Hematochezia (HP:0002573)2.00033495
97Glomerulopathy (HP:0100820)1.99819940
98Vertigo (HP:0002321)1.99812492
99Polyneuropathy (HP:0001271)1.99614847
100Keratoconjunctivitis (HP:0001096)1.99513234
101Increased IgE level (HP:0003212)1.99238878
102Chest pain (HP:0100749)1.95474272
103Inappropriate behavior (HP:0000719)1.94116076
104Skin ulcer (HP:0200042)1.93657756
105Increased IgM level (HP:0003496)1.93138493
106Chronic otitis media (HP:0000389)1.92799933
107Progressive neurologic deterioration (HP:0002344)1.91724031
108Neuronal loss in central nervous system (HP:0002529)1.90162972
109Episodic fever (HP:0001954)1.90099951
110Urinary glycosaminoglycan excretion (HP:0003541)1.89910369
111Mucopolysacchariduria (HP:0008155)1.89910369
112Restrictive lung disease (HP:0002091)1.89348978
113Gangrene (HP:0100758)1.88414239
114Poikiloderma (HP:0001029)1.87399461
115Spontaneous hematomas (HP:0007420)1.85880693
116IgM deficiency (HP:0002850)1.85690372
117Purpura (HP:0000979)1.85239885
118Progressive visual loss (HP:0000529)1.83679802
119Porencephaly (HP:0002132)1.83310373
120Abnormal platelet function (HP:0011869)1.83213759
121Impaired platelet aggregation (HP:0003540)1.83213759
122Bone cyst (HP:0012062)1.82838912
123Nausea (HP:0002018)1.81777520
124Abnormality of polysaccharide metabolism (HP:0011012)1.78750448
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78750448
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78750448
127Colitis (HP:0002583)1.78672849
128Abnormality of eosinophils (HP:0001879)1.77821237
129Pathologic fracture (HP:0002756)1.77687385
130Glomerulonephritis (HP:0000099)1.77305301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.56757531
2MAP3K144.45830514
3RIPK43.77823889
4TXK3.54081668
5IRAK33.44302179
6TBK13.34457711
7MAP4K13.33665526
8IRAK43.33085893
9IKBKE2.62804630
10KIT2.52582183
11GRK72.44226129
12JAK32.29213157
13IKBKB2.16534564
14EPHB12.14606315
15ZAP702.13308435
16PRPF4B2.04523790
17ERN12.03285795
18PIM21.98851799
19TYK21.96299030
20TAOK31.84118372
21BTK1.78795761
22TEC1.76374290
23SYK1.64515574
24CHUK1.63857682
25PBK1.48456313
26HCK1.33400459
27EPHA31.32808003
28JAK11.29840834
29IRAK21.29549132
30LYN1.23963650
31FES1.23308811
32MAP2K31.22928713
33PIM11.20997056
34ABL21.19889572
35TAOK21.17357206
36MAP3K31.16887399
37NME21.13520017
38LCK1.10635509
39CSF1R1.10399049
40JAK21.08068098
41EIF2AK21.04664029
42DDR21.04540625
43MATK1.02184605
44CSK0.98686744
45ADRBK20.97306739
46MST40.91075042
47MOS0.90934460
48FLT30.90628159
49MAP3K120.89141143
50TNK20.88830158
51RIPK10.87669104
52DAPK20.87626621
53FGFR30.87375243
54BMX0.86622817
55NEK90.85003200
56CDC42BPA0.82819952
57PIK3CG0.81174206
58MAP3K130.80378585
59TAOK10.79709997
60STK40.76636776
61PRKCD0.75617550
62MST1R0.75073878
63ERBB40.71793969
64CAMKK20.69274896
65CLK10.67840574
66MAP3K50.66469633
67TGFBR20.66377639
68BMPR20.65227900
69STK100.63924161
70PDPK10.63889264
71RPS6KA40.62759516
72ABL10.62594812
73CDK60.59961977
74LRRK20.58962627
75IRAK10.57885609
76TGFBR10.57209928
77MAPK70.56356646
78TRPM70.54926586
79EIF2AK30.54794264
80ITK0.54416029
81MAP2K60.53901413
82FGFR40.53648084
83MAP3K100.49500748
84YES10.48939306
85EGFR0.48161189
86SIK30.47570690
87PRKG20.47248494
88MAPKAPK20.44393021
89FGR0.44340945
90RPS6KA60.44139092
91PAK40.43409967
92BMPR1B0.43114931
93NLK0.42849437
94SCYL20.40941306
95MAP3K60.40170582
96MARK30.39934333
97CDK40.37922409
98MUSK0.37455430
99TTN0.36160922
100CDK80.35516736
101RPS6KA20.34549972
102MAPK40.33765835
103SIK20.33249225
104MAPK120.33024730
105CAMK1D0.32905062
106PDK10.32094533
107PAK20.31789217
108MAP3K10.30401068
109KSR20.30030713
110ALK0.29859928
111MAP3K110.29210558
112MAP4K20.29009359
113DAPK30.28864380
114PRKCQ0.28538854
115TESK20.28365324
116MAP3K20.27671556
117CDK190.25850155
118FYN0.25473130
119PTK60.25448220
120GRK60.25345677
121ACVR1B0.24961093
122ATR0.24650551
123HIPK20.24548667
124MAPK30.24247257
125RPS6KL10.23482973
126RPS6KC10.23482973
127SGK30.21416585
128IGF1R0.21209080
129MARK20.19319216
130MAP2K40.19286271

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.94058812
2Leishmaniasis_Homo sapiens_hsa051403.72652620
3NOD-like receptor signaling pathway_Homo sapiens_hsa046213.26702533
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.96054373
5Legionellosis_Homo sapiens_hsa051342.77701603
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.77165110
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.65007525
8Staphylococcus aureus infection_Homo sapiens_hsa051502.60730541
9Osteoclast differentiation_Homo sapiens_hsa043802.56324698
10Pertussis_Homo sapiens_hsa051332.47370531
11Rheumatoid arthritis_Homo sapiens_hsa053232.42395551
12Type I diabetes mellitus_Homo sapiens_hsa049402.42054715
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39248769
14Malaria_Homo sapiens_hsa051442.35775019
15Tuberculosis_Homo sapiens_hsa051522.33502329
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.30404692
17Measles_Homo sapiens_hsa051622.19732255
18African trypanosomiasis_Homo sapiens_hsa051432.01482833
19TNF signaling pathway_Homo sapiens_hsa046681.88645355
20Allograft rejection_Homo sapiens_hsa053301.86215410
21Salmonella infection_Homo sapiens_hsa051321.84346180
22Asthma_Homo sapiens_hsa053101.80424685
23Influenza A_Homo sapiens_hsa051641.76817782
24Hematopoietic cell lineage_Homo sapiens_hsa046401.75836111
25Phagosome_Homo sapiens_hsa041451.67392853
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63889997
27Lysosome_Homo sapiens_hsa041421.63529803
28Herpes simplex infection_Homo sapiens_hsa051681.54504521
29B cell receptor signaling pathway_Homo sapiens_hsa046621.53980168
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50753395
31Other glycan degradation_Homo sapiens_hsa005111.44450460
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.35373177
33Toxoplasmosis_Homo sapiens_hsa051451.33577221
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31508130
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.29568103
36Shigellosis_Homo sapiens_hsa051311.26060233
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24571847
38Apoptosis_Homo sapiens_hsa042101.18009346
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.16091779
40Chemokine signaling pathway_Homo sapiens_hsa040621.09476563
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04468828
42Hepatitis B_Homo sapiens_hsa051611.02197562
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01179395
44Hepatitis C_Homo sapiens_hsa051601.00056646
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98685460
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97879964
47Antigen processing and presentation_Homo sapiens_hsa046120.96871333
48Amoebiasis_Homo sapiens_hsa051460.91237154
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87999841
50Acute myeloid leukemia_Homo sapiens_hsa052210.82295422
51Collecting duct acid secretion_Homo sapiens_hsa049660.78239622
52Prion diseases_Homo sapiens_hsa050200.77981965
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.72852379
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69244037
55Primary immunodeficiency_Homo sapiens_hsa053400.67202054
56Complement and coagulation cascades_Homo sapiens_hsa046100.66791278
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62475319
58T cell receptor signaling pathway_Homo sapiens_hsa046600.62319807
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62218196
60Autoimmune thyroid disease_Homo sapiens_hsa053200.62206458
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.61163852
62Platelet activation_Homo sapiens_hsa046110.58386821
63Chronic myeloid leukemia_Homo sapiens_hsa052200.55488075
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54263651
65Viral myocarditis_Homo sapiens_hsa054160.54167895
66Epstein-Barr virus infection_Homo sapiens_hsa051690.53063601
67Pancreatic cancer_Homo sapiens_hsa052120.52538252
68Systemic lupus erythematosus_Homo sapiens_hsa053220.50349246
69Dorso-ventral axis formation_Homo sapiens_hsa043200.50121752
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47090981
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45533536
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.45110781
73Caffeine metabolism_Homo sapiens_hsa002320.45059801
74HIF-1 signaling pathway_Homo sapiens_hsa040660.44386225
75Bladder cancer_Homo sapiens_hsa052190.41916961
76Non-small cell lung cancer_Homo sapiens_hsa052230.40317865
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38699455
78Sphingolipid metabolism_Homo sapiens_hsa006000.37680662
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37571188
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37157725
81HTLV-I infection_Homo sapiens_hsa051660.36911661
82Steroid biosynthesis_Homo sapiens_hsa001000.36139095
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34044544
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33598670
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31849604
86Prolactin signaling pathway_Homo sapiens_hsa049170.31309199
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30838971
88GnRH signaling pathway_Homo sapiens_hsa049120.28991070
89Renin-angiotensin system_Homo sapiens_hsa046140.28084321
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.27703952
91Viral carcinogenesis_Homo sapiens_hsa052030.26729061
92Renal cell carcinoma_Homo sapiens_hsa052110.25593161
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25254707
94mTOR signaling pathway_Homo sapiens_hsa041500.23786370
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23329268
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.23237477
97Type II diabetes mellitus_Homo sapiens_hsa049300.22428869
98Selenocompound metabolism_Homo sapiens_hsa004500.21958243
99Insulin resistance_Homo sapiens_hsa049310.20941220
100Endocytosis_Homo sapiens_hsa041440.20223854
101Notch signaling pathway_Homo sapiens_hsa043300.20187576
102PPAR signaling pathway_Homo sapiens_hsa033200.20155738
103Pentose phosphate pathway_Homo sapiens_hsa000300.18792145
104VEGF signaling pathway_Homo sapiens_hsa043700.18402083
105DNA replication_Homo sapiens_hsa030300.18345803
106p53 signaling pathway_Homo sapiens_hsa041150.18146346
107Ether lipid metabolism_Homo sapiens_hsa005650.17992951
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.17911594
109MAPK signaling pathway_Homo sapiens_hsa040100.17688596
110Small cell lung cancer_Homo sapiens_hsa052220.17206040
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14290628
112Arachidonic acid metabolism_Homo sapiens_hsa005900.13873205
113Mineral absorption_Homo sapiens_hsa049780.13496190
114Starch and sucrose metabolism_Homo sapiens_hsa005000.13080693
115Histidine metabolism_Homo sapiens_hsa003400.12743233
116FoxO signaling pathway_Homo sapiens_hsa040680.12517201
117Ribosome_Homo sapiens_hsa030100.11342855
118Vibrio cholerae infection_Homo sapiens_hsa051100.11102318

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